FAM129B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)5.09784128
2hemidesmosome assembly (GO:0031581)4.79314589
3wound healing, spreading of epidermal cells (GO:0035313)4.72068737
4apoptotic cell clearance (GO:0043277)4.70094133
5skin morphogenesis (GO:0043589)4.35611101
6endodermal cell differentiation (GO:0035987)4.23578397
7barbed-end actin filament capping (GO:0051016)4.23025712
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.76327900
9regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.73629796
10wound healing, spreading of cells (GO:0044319)3.69051999
11low-density lipoprotein particle clearance (GO:0034383)3.67985799
12basement membrane organization (GO:0071711)3.66107340
13epithelial cell-cell adhesion (GO:0090136)3.61825481
14negative regulation of fatty acid transport (GO:2000192)3.61717694
15protein retention in ER lumen (GO:0006621)3.59264917
16cell-substrate junction assembly (GO:0007044)3.58174665
17hypotonic response (GO:0006971)3.44241063
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.39867145
19plasma membrane repair (GO:0001778)3.39007361
20chondrocyte proliferation (GO:0035988)3.38834713
21positive regulation of endothelial cell apoptotic process (GO:2000353)3.38690350
22collagen fibril organization (GO:0030199)3.37941501
23protein localization to endosome (GO:0036010)3.36966834
24vascular endothelial growth factor signaling pathway (GO:0038084)3.29720646
25regulation of integrin activation (GO:0033623)3.28531288
26positive regulation of p38MAPK cascade (GO:1900745)3.23120326
27protein heterotrimerization (GO:0070208)3.22303739
28focal adhesion assembly (GO:0048041)3.19334710
29cell-substrate adherens junction assembly (GO:0007045)3.19334710
30axon extension involved in axon guidance (GO:0048846)3.16064589
31neuron projection extension involved in neuron projection guidance (GO:1902284)3.16064589
32modulation by symbiont of host immune response (GO:0052553)3.15271128
33positive regulation by symbiont of host defense response (GO:0052509)3.15271128
34modulation by symbiont of host defense response (GO:0052031)3.15271128
35modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.15271128
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.15271128
37positive regulation by organism of defense response of other organism involved in symbiotic interact3.15271128
38stress fiber assembly (GO:0043149)3.15051570
39regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11911273
40vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.09417419
41desmosome organization (GO:0002934)3.09042788
42cellular response to interferon-alpha (GO:0035457)3.04936970
43positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.04274128
44extracellular matrix disassembly (GO:0022617)3.03180326
45glomerular visceral epithelial cell development (GO:0072015)3.02374649
46collagen metabolic process (GO:0032963)3.00897107
47endothelial cell chemotaxis (GO:0035767)2.97680215
48substrate-dependent cell migration (GO:0006929)2.95831759
49retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.95453178
50collagen catabolic process (GO:0030574)2.95423137
51regulation of membrane protein ectodomain proteolysis (GO:0051043)2.94963549
52positive regulation of receptor recycling (GO:0001921)2.94046353
53negative regulation of chondrocyte differentiation (GO:0032331)2.93466196
54pinocytosis (GO:0006907)2.93214796
55cellular response to vitamin (GO:0071295)2.92398089
56positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.92155243
57cytoskeletal anchoring at plasma membrane (GO:0007016)2.91983276
58regulation of hippo signaling (GO:0035330)2.91386116
59semaphorin-plexin signaling pathway (GO:0071526)2.90202075
60dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.90023821
61response to laminar fluid shear stress (GO:0034616)2.87233359
62retina vasculature morphogenesis in camera-type eye (GO:0061299)2.86310865
63substrate adhesion-dependent cell spreading (GO:0034446)2.85846039
64polarized epithelial cell differentiation (GO:0030859)2.85576893
65mesodermal cell differentiation (GO:0048333)2.84471882
66regulation of tight junction assembly (GO:2000810)2.84243292
67activation of Rac GTPase activity (GO:0032863)2.84085236
68multicellular organismal macromolecule metabolic process (GO:0044259)2.83624691
69COPI coating of Golgi vesicle (GO:0048205)2.83111500
70Golgi transport vesicle coating (GO:0048200)2.83111500
71type B pancreatic cell proliferation (GO:0044342)2.82990332
72glial cell migration (GO:0008347)2.80537753
73endocytic recycling (GO:0032456)2.76592452
74membrane protein ectodomain proteolysis (GO:0006509)2.76494371
75multicellular organismal catabolic process (GO:0044243)2.75881159
76negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.75821758
77epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74867777
78branching involved in mammary gland duct morphogenesis (GO:0060444)2.74109609
79negative regulation of smooth muscle cell migration (GO:0014912)2.73028049
80branching involved in salivary gland morphogenesis (GO:0060445)2.72739985
81adhesion of symbiont to host cell (GO:0044650)2.72031478
82virion attachment to host cell (GO:0019062)2.72031478
83peptidyl-proline hydroxylation (GO:0019511)2.71843060
84mammary gland epithelial cell proliferation (GO:0033598)2.71311707
85glomerular epithelial cell development (GO:0072310)2.70213266
86response to fluid shear stress (GO:0034405)2.69539409
87positive regulation of blood vessel endothelial cell migration (GO:0043536)2.68192932
88membrane raft organization (GO:0031579)2.68072912
89multicellular organismal metabolic process (GO:0044236)2.66212946
90negative regulation of anoikis (GO:2000811)2.65358034
91regulation of cholesterol storage (GO:0010885)2.64428048
92regulation of glucose import in response to insulin stimulus (GO:2001273)2.63661662
93renal filtration (GO:0097205)2.60957328
94endothelial cell morphogenesis (GO:0001886)2.60880783
95adherens junction assembly (GO:0034333)2.59045719
96regulation of SMAD protein import into nucleus (GO:0060390)2.56664499
97cell migration involved in heart development (GO:0060973)2.56508396
98positive regulation of extracellular matrix organization (GO:1903055)2.56417490
99positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.55554541
100hyaluronan catabolic process (GO:0030214)2.55178673
101extracellular matrix assembly (GO:0085029)2.54583811
102actin filament bundle assembly (GO:0051017)2.53988940
103actin filament bundle organization (GO:0061572)2.53988940
104atrioventricular valve morphogenesis (GO:0003181)2.53484373
105positive regulation of Cdc42 GTPase activity (GO:0043089)2.53398747
106negative regulation of adherens junction organization (GO:1903392)2.52470265
107negative regulation of focal adhesion assembly (GO:0051895)2.52470265
108negative regulation of cell junction assembly (GO:1901889)2.52470265
109regulation of early endosome to late endosome transport (GO:2000641)2.51812349
110regulation of integrin-mediated signaling pathway (GO:2001044)2.51750744
111cell migration involved in sprouting angiogenesis (GO:0002042)2.51331460
112regulation of transforming growth factor beta1 production (GO:0032908)2.51306028
113apoptotic process involved in morphogenesis (GO:0060561)2.49757113
114extracellular fibril organization (GO:0043206)2.49519342
115embryo implantation (GO:0007566)2.49495762
116cellular response to vitamin D (GO:0071305)2.48941182
117cortical actin cytoskeleton organization (GO:0030866)2.48740168
118heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.47607226
119cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46809440
120regulation of extracellular matrix disassembly (GO:0010715)2.46289455
121regulation of mononuclear cell migration (GO:0071675)2.45182489
122sequestering of extracellular ligand from receptor (GO:0035581)2.44668775
123protein hydroxylation (GO:0018126)2.44277949
124regulation of apoptotic process involved in morphogenesis (GO:1902337)2.44274618
125regulation of macrophage cytokine production (GO:0010935)2.43810042
126adhesion of symbiont to host (GO:0044406)2.43727415
127regulation of podosome assembly (GO:0071801)2.43500625
128fibril organization (GO:0097435)2.43018997
129response to magnesium ion (GO:0032026)2.43003034
130regulation of p38MAPK cascade (GO:1900744)2.42984180
131hippo signaling (GO:0035329)2.42452618
132positive regulation of osteoblast proliferation (GO:0033690)2.42403746
133platelet aggregation (GO:0070527)2.41932633
134peptide cross-linking (GO:0018149)2.41675083
135mRNA transcription (GO:0009299)2.41557121
136integrin-mediated signaling pathway (GO:0007229)2.41472686
137surfactant homeostasis (GO:0043129)2.40582810
138glomerular basement membrane development (GO:0032836)2.40493210
139regulation of interferon-beta biosynthetic process (GO:0045357)2.39495152
140activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.38811935
141maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.38471068
142decidualization (GO:0046697)2.37504168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.29758248
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.94711220
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.83843585
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50780750
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.99996621
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95607863
7CLOCK_20551151_ChIP-Seq_293T_Human2.53230617
8* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.35223568
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.33297142
10* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.30732742
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21903580
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.13674625
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11461776
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.05761751
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.04074414
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.01850073
17KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94285587
18* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.88206859
19* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.88206859
20SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.86229655
21RACK7_27058665_Chip-Seq_MCF-7_Human1.84939986
22* ATF3_27146783_Chip-Seq_COLON_Human1.80891478
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.76510635
24* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72077152
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.70710797
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.70074861
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68917904
28P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68661284
29NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62458931
30KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61116358
31LXR_22292898_ChIP-Seq_THP-1_Human1.60592656
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.58933064
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.56956461
34* FOXO3_23340844_ChIP-Seq_DLD1_Human1.55959048
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.54803933
36ZNF263_19887448_ChIP-Seq_K562_Human1.54290301
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.53761559
38* CJUN_26792858_Chip-Seq_BT549_Human1.53468016
39* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.53215558
40* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52239829
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.52055024
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.50705073
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50556241
44* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.48043796
45IRF8_27001747_Chip-Seq_BMDM_Mouse1.45624897
46SOX2_20726797_ChIP-Seq_SW620_Human1.43461194
47IRF8_22096565_ChIP-ChIP_GC-B_Human1.43178924
48NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.42319890
49BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41980284
50UBF1/2_26484160_Chip-Seq_HMECs_Human1.41850141
51SOX9_24532713_ChIP-Seq_HFSC_Mouse1.41813812
52KDM2B_26808549_Chip-Seq_DND41_Human1.41582145
53ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.40739066
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40589730
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40429628
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40136432
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39738680
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.39343987
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.36486007
60BRD4_25478319_ChIP-Seq_HGPS_Human1.34108246
61UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33660962
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32739109
63* TCF7_22412390_ChIP-Seq_EML_Mouse1.28218454
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26261804
65TP53_22127205_ChIP-Seq_IMR90_Human1.25840597
66VDR_21846776_ChIP-Seq_THP-1_Human1.25638225
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24003988
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.19976350
69* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17267714
70ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17060069
71FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15730857
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13191126
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12878400
74* KDM2B_26808549_Chip-Seq_K562_Human1.12820453
75TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12812906
76TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11431791
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10936742
78KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10921332
79NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09814869
80HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09086379
81TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.08846013
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07363740
83* RUNX1_27514584_Chip-Seq_MCF-7_Human1.06717980
84* KLF5_25053715_ChIP-Seq_YYC3_Human1.05985745
85VDR_24763502_ChIP-Seq_THP-1_Human1.05797980
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.05708832
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.05038586
88MYC_22102868_ChIP-Seq_BL_Human1.04991949
89GATA6_25053715_ChIP-Seq_YYC3_Human1.04622125
90CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04593324
91NCOR1_26117541_ChIP-Seq_K562_Human1.04441835
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.02410376
93TBX20_22080862_ChIP-Seq_HEART_Mouse1.02410376
94* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02344325
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.02064236
96NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02018234
97SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01913944
98CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00129525
99SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00084538
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99895279
101SPI1_23127762_ChIP-Seq_K562_Human0.98776789
102STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98071685
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97798518
104SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97289243
105TET1_21490601_ChIP-Seq_MESCs_Mouse0.97213537
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.97070793
107AR_21909140_ChIP-Seq_LNCAP_Human0.96959188
108CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.96629408
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96141876
110SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95820884
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95047425
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94521381
113KDM2B_26808549_Chip-Seq_JURKAT_Human0.94475123
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94031957
115ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93215113
116MAF_26560356_Chip-Seq_TH1_Human0.92890846
117NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92442024
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92442024
119SA1_27219007_Chip-Seq_ERYTHROID_Human0.90762547
120RXR_22158963_ChIP-Seq_LIVER_Mouse0.90654432
121SMAD_19615063_ChIP-ChIP_OVARY_Human0.90529407
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90470952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.85751651
2MP0003705_abnormal_hypodermis_morpholog4.51021593
3MP0005275_abnormal_skin_tensile3.94092884
4MP0003566_abnormal_cell_adhesion3.26530203
5MP0001958_emphysema2.72377018
6MP0010352_gastrointestinal_tract_polyps2.62052612
7MP0005257_abnormal_intraocular_pressure2.58522953
8MP0004272_abnormal_basement_membrane2.53570719
9MP0003279_aneurysm2.49201775
10MP0010234_abnormal_vibrissa_follicle2.27083842
11MP0005623_abnormal_meninges_morphology2.19393773
12MP0005023_abnormal_wound_healing2.16881179
13MP0003303_peritoneal_inflammation2.16067925
14MP0005058_abnormal_lysosome_morphology2.10535379
15MP0002877_abnormal_melanocyte_morpholog2.06434254
16MP0003091_abnormal_cell_migration1.98419615
17MP0003300_gastrointestinal_ulcer1.93939621
18MP0002060_abnormal_skin_morphology1.91528270
19MP0006054_spinal_hemorrhage1.88375699
20MP0002796_impaired_skin_barrier1.80892136
21MP0005076_abnormal_cell_differentiation1.75792670
22MP0005503_abnormal_tendon_morphology1.69332678
23MP0005451_abnormal_body_composition1.64057642
24MP0003453_abnormal_keratinocyte_physiol1.55808374
25MP0000751_myopathy1.54714558
26MP0004947_skin_inflammation1.53719153
27MP0001849_ear_inflammation1.52891163
28MP0005409_darkened_coat_color1.51300666
29MP0000733_abnormal_muscle_development1.51290641
30MP0003448_altered_tumor_morphology1.41767183
31MP0003436_decreased_susceptibility_to1.40277702
32MP0010030_abnormal_orbit_morphology1.35356939
33MP0009278_abnormal_bone_marrow1.33731535
34MP0005501_abnormal_skin_physiology1.31543378
35MP0000767_abnormal_smooth_muscle1.29421283
36MP0000858_altered_metastatic_potential1.28823101
37MP0009384_cardiac_valve_regurgitation1.28592289
38MP0002254_reproductive_system_inflammat1.27834991
39MP0001243_abnormal_dermal_layer1.27764152
40MP0010368_abnormal_lymphatic_system1.26764949
41MP0000762_abnormal_tongue_morphology1.26204807
42MP0001533_abnormal_skeleton_physiology1.26202352
43MP0004858_abnormal_nervous_system1.23796793
44MP0002295_abnormal_pulmonary_circulatio1.23516630
45MP0005508_abnormal_skeleton_morphology1.23009269
46MP0000750_abnormal_muscle_regeneration1.21275317
47MP0002896_abnormal_bone_mineralization1.16272025
48MP0004185_abnormal_adipocyte_glucose1.15428091
49MP0005595_abnormal_vascular_smooth1.15381513
50MP0004233_abnormal_muscle_weight1.15190727
51MP0003172_abnormal_lysosome_physiology1.13682892
52MP0002998_abnormal_bone_remodeling1.13392207
53MP0009780_abnormal_chondrocyte_physiolo1.12543604
54MP0003941_abnormal_skin_development1.11024858
55MP0010307_abnormal_tumor_latency1.10220394
56MP0001216_abnormal_epidermal_layer1.09433927
57MP0005390_skeleton_phenotype1.08363399
58MP0003045_fibrosis1.07772489
59MP0000343_altered_response_to1.06885381
60MP0009840_abnormal_foam_cell1.05373076
61MP0008260_abnormal_autophagy1.01310417
62MP0003191_abnormal_cellular_cholesterol0.99346384
63MP0000534_abnormal_ureter_morphology0.98348640
64MP0004510_myositis0.97350408
65MP0000678_abnormal_parathyroid_gland0.95630570
66MP0005165_increased_susceptibility_to0.95380618
67MP0000537_abnormal_urethra_morphology0.94305097
68MP0001542_abnormal_bone_strength0.93379173
69MP0002933_joint_inflammation0.92609697
70MP0003329_amyloid_beta_deposits0.91408883
71MP0003283_abnormal_digestive_organ0.91218553
72MP0001879_abnormal_lymphatic_vessel0.91043404
73MP0001915_intracranial_hemorrhage0.90249662
74MP0010771_integument_phenotype0.89128767
75MP0009053_abnormal_anal_canal0.88756158
76MP0002089_abnormal_postnatal_growth/wei0.88331983
77MP0004782_abnormal_surfactant_physiolog0.87857620
78MP0002282_abnormal_trachea_morphology0.86183480
79MP0008004_abnormal_stomach_pH0.85729939
80MP0006082_CNS_inflammation0.85552937
81MP0001614_abnormal_blood_vessel0.84018430
82MP0001348_abnormal_lacrimal_gland0.83901055
83MP0010678_abnormal_skin_adnexa0.82707613
84MP0002168_other_aberrant_phenotype0.82259368
85MP0005164_abnormal_response_to0.80448264
86MP0003795_abnormal_bone_structure0.78319518
87MP0005367_renal/urinary_system_phenotyp0.78026160
88MP0000516_abnormal_urinary_system0.78026160
89MP0000013_abnormal_adipose_tissue0.78013453
90MP0000467_abnormal_esophagus_morphology0.77795518
91MP0005197_abnormal_uvea_morphology0.77613714
92MP0003828_pulmonary_edema0.77055426
93MP0000759_abnormal_skeletal_muscle0.75686412
94MP0001851_eye_inflammation0.75636652
95MP0002098_abnormal_vibrissa_morphology0.75588824
96MP0002419_abnormal_innate_immunity0.74665423
97MP0000579_abnormal_nail_morphology0.74324013
98MP0002925_abnormal_cardiovascular_devel0.74231710
99MP0000377_abnormal_hair_follicle0.74021882
100MP0001299_abnormal_eye_distance/0.73991865
101MP0005167_abnormal_blood-brain_barrier0.73813228
102MP0003115_abnormal_respiratory_system0.72829478
103MP0009931_abnormal_skin_appearance0.72700990
104MP0005621_abnormal_cell_physiology0.72658834
105MP0005375_adipose_tissue_phenotype0.72547362
106MP0000627_abnormal_mammary_gland0.72303012
107MP0002128_abnormal_blood_circulation0.71835862
108MP0000604_amyloidosis0.71235349
109MP0003950_abnormal_plasma_membrane0.70269294
110MP0001175_abnormal_lung_morphology0.68703426
111MP0002113_abnormal_skeleton_development0.68486910
112MP0002234_abnormal_pharynx_morphology0.68226953
113MP0005193_abnormal_anterior_eye0.68184938
114MP0003075_altered_response_to0.67588200
115MP0000462_abnormal_digestive_system0.67347727
116MP0000003_abnormal_adipose_tissue0.67191981
117MP0001545_abnormal_hematopoietic_system0.66900282
118MP0005397_hematopoietic_system_phenotyp0.66900282
119MP0003385_abnormal_body_wall0.64137024
120MP0000749_muscle_degeneration0.63744769
121MP0004264_abnormal_extraembryonic_tissu0.62903134
122MP0000428_abnormal_craniofacial_morphol0.62741261
123MP0000163_abnormal_cartilage_morphology0.61107247

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.62985497
2Protrusio acetabuli (HP:0003179)5.39817547
3Atrophic scars (HP:0001075)4.23824510
4Cerebral aneurysm (HP:0004944)4.07967566
5Shallow orbits (HP:0000586)3.82576264
6Peritonitis (HP:0002586)3.57690885
7Cervical subluxation (HP:0003308)3.51824664
8Ankle contracture (HP:0006466)3.47662842
9Aortic dissection (HP:0002647)3.31075581
10Increased cerebral lipofuscin (HP:0011813)3.18986861
11Increased connective tissue (HP:0009025)3.16734653
12Fragile skin (HP:0001030)3.14461283
13Vertebral compression fractures (HP:0002953)2.96784174
14Dilatation of the ascending aorta (HP:0005111)2.93544483
15Aortic aneurysm (HP:0004942)2.93370907
16Osteolytic defects of the hand bones (HP:0009699)2.78515409
17Osteolytic defects of the phalanges of the hand (HP:0009771)2.78515409
18Hyperacusis (HP:0010780)2.76749012
19Interstitial pulmonary disease (HP:0006530)2.76741800
20Right ventricular cardiomyopathy (HP:0011663)2.76517215
21Natal tooth (HP:0000695)2.73935424
22Distal lower limb muscle weakness (HP:0009053)2.70936066
23Genu recurvatum (HP:0002816)2.67915859
24Spinal rigidity (HP:0003306)2.66526633
25Ulnar bowing (HP:0003031)2.64586054
26Distal upper limb amyotrophy (HP:0007149)2.64066702
27Upper limb amyotrophy (HP:0009129)2.64066702
28Mitral valve prolapse (HP:0001634)2.58355092
29Milia (HP:0001056)2.56074666
30Bladder diverticulum (HP:0000015)2.55854909
31Broad metatarsal (HP:0001783)2.53077328
32Wormian bones (HP:0002645)2.50230017
33Soft skin (HP:0000977)2.49963844
34Short nail (HP:0001799)2.43447419
35Blue sclerae (HP:0000592)2.40350499
36Difficulty climbing stairs (HP:0003551)2.34823699
37Aneurysm (HP:0002617)2.32300045
38Wrist flexion contracture (HP:0001239)2.32288865
39Mitral regurgitation (HP:0001653)2.32150896
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.31379945
41Dysostosis multiplex (HP:0000943)2.30805253
42Increased density of long bones (HP:0006392)2.28111147
43Type 1 muscle fiber predominance (HP:0003803)2.26902903
44Hand muscle atrophy (HP:0009130)2.25509649
45Alopecia of scalp (HP:0002293)2.24397492
46Radial bowing (HP:0002986)2.23384286
47Lower limb amyotrophy (HP:0007210)2.21950036
48Vascular tortuosity (HP:0004948)2.20199140
49Abnormality of dentin (HP:0010299)2.18505268
50Bowing of the arm (HP:0006488)2.16348060
51Bowed forearm bones (HP:0003956)2.16348060
52Distal lower limb amyotrophy (HP:0008944)2.15521676
53Generalized amyotrophy (HP:0003700)2.15104179
54Thick nail (HP:0001805)2.14476071
55Thin bony cortex (HP:0002753)2.13753592
56Mucopolysacchariduria (HP:0008155)2.11886707
57Urinary glycosaminoglycan excretion (HP:0003541)2.11886707
58Mildly elevated creatine phosphokinase (HP:0008180)2.10747925
59Myocardial infarction (HP:0001658)2.10181669
60Slender build (HP:0001533)2.09649415
61Disproportionate tall stature (HP:0001519)2.09600117
62Follicular hyperkeratosis (HP:0007502)2.08551585
63Elbow flexion contracture (HP:0002987)2.08113532
64Arterial tortuosity (HP:0005116)2.07652908
65Advanced eruption of teeth (HP:0006288)2.07129696
66Vacuolated lymphocytes (HP:0001922)2.05991824
67Abnormality of the acetabulum (HP:0003170)2.04908683
68Joint laxity (HP:0001388)2.04726214
69Abnormality of the distal phalanges of the toes (HP:0010182)2.02467728
70Hematochezia (HP:0002573)2.02000528
71Axonal loss (HP:0003447)2.00864641
72Scapular winging (HP:0003691)2.00265902
73Aortic regurgitation (HP:0001659)1.99643088
74Achilles tendon contracture (HP:0001771)1.99273488
75Neonatal short-limb short stature (HP:0008921)1.98163312
76Reduced subcutaneous adipose tissue (HP:0003758)1.95524193
77Nuclear cataract (HP:0100018)1.95051689
78Flat acetabular roof (HP:0003180)1.94937636
79Mitral stenosis (HP:0001718)1.93963878
80Cardiovascular calcification (HP:0011915)1.92859718
81Abnormal ossification of hand bones (HP:0005921)1.91916748
82Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91765165
83Abnormality of polysaccharide metabolism (HP:0011012)1.91765165
84Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91765165
85Camptodactyly of toe (HP:0001836)1.90702674
86Abnormality of skeletal muscle fiber size (HP:0012084)1.90549681
87Hyperextensible skin (HP:0000974)1.86739340
88Onycholysis (HP:0001806)1.83390642
89Coxa vara (HP:0002812)1.83040831
90Absent frontal sinuses (HP:0002688)1.82746307
91Long toe (HP:0010511)1.82625842
92Joint stiffness (HP:0001387)1.82500717
93Tibial bowing (HP:0002982)1.82144552
94Abnormality of carpal bone ossification (HP:0006257)1.80295312
95Spinal cord compression (HP:0002176)1.80275277
96Femoral bowing (HP:0002980)1.78762557
97Biconcave vertebral bodies (HP:0004586)1.78738193
98Abnormality of oral frenula (HP:0000190)1.78588065
99Eczematoid dermatitis (HP:0000976)1.78409656
100Fused cervical vertebrae (HP:0002949)1.78260110
101Insomnia (HP:0100785)1.77509610
102Plantar hyperkeratosis (HP:0007556)1.77441444
103Abnormality of the peritoneum (HP:0002585)1.77323625
104Fragile nails (HP:0001808)1.77203008
105Bronchomalacia (HP:0002780)1.77071578
106Entropion (HP:0000621)1.76856592
107Turricephaly (HP:0000262)1.74770572
108Persistence of primary teeth (HP:0006335)1.73917779
109Abnormality of glycolipid metabolism (HP:0010969)1.73510902
110Abnormality of liposaccharide metabolism (HP:0010968)1.73510902
111Abnormality of glycosphingolipid metabolism (HP:0004343)1.73510902
112Bowel diverticulosis (HP:0005222)1.72941843
113Abnormality of the calcaneus (HP:0008364)1.72714501
114Deviation of the hallux (HP:0010051)1.72222496
115Spondylolisthesis (HP:0003302)1.72069626
116Trismus (HP:0000211)1.71445048
117Abnormality of the Achilles tendon (HP:0005109)1.70414252
118Neurofibrillary tangles (HP:0002185)1.70053064
119Subacute progressive viral hepatitis (HP:0006572)1.69324806
120Increased variability in muscle fiber diameter (HP:0003557)1.68133682
121Cerebral inclusion bodies (HP:0100314)1.68094841
122Beaking of vertebral bodies (HP:0004568)1.66699476
123Hallux valgus (HP:0001822)1.66619340
124Spinal cord lesions (HP:0100561)1.66594740
125Syringomyelia (HP:0003396)1.66594740
126Abnormal delivery (HP:0001787)1.66507509
127Broad face (HP:0000283)1.66482134
128Frequent falls (HP:0002359)1.65293809
129Increased mean platelet volume (HP:0011877)1.65103649

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.66230997
2TTN3.67890536
3IRAK33.47146929
4ERN13.30461428
5PKN23.29068930
6EPHA23.07056701
7DDR22.64935921
8RIPK12.39190096
9PDGFRA2.30281273
10PTK62.11736548
11BMX2.10492770
12LMTK22.06181799
13LRRK22.03160155
14SMG11.96643365
15PAK41.93656830
16EEF2K1.75807216
17MAP3K31.75332047
18PTK21.71134302
19TGFBR21.70657667
20EPHB11.66639418
21TESK11.64955928
22LATS21.63789487
23LATS11.61951341
24PRPF4B1.61042725
25RPS6KA41.60889895
26FER1.60003826
27TRPM71.57331396
28EPHB21.54877433
29MYLK1.52484598
30TBK11.41690317
31PAK21.40359867
32SIK11.36770162
33NME21.34666435
34ERBB41.34221998
35STK101.32053868
36PIM21.31011413
37MST1R1.27720801
38MET1.25249971
39MAPKAPK31.21985227
40SCYL21.21023295
41MAP2K31.18527364
42PRKD21.17706740
43MOS1.14843654
44CDC42BPA1.13708706
45MAP3K61.12908063
46STK381.05381351
47MAP3K101.04599185
48EPHA31.04229404
49PDGFRB1.03824195
50ARAF1.03200863
51KIT0.98172305
52CAMK1D0.95503668
53MAP3K110.95160974
54ILK0.91652747
55CDK60.88756281
56MTOR0.86983763
57LIMK10.86369558
58MAP2K10.86108846
59MAP3K20.86096972
60TAOK10.84853546
61FGFR40.82710255
62DMPK0.82154505
63STK30.80935926
64FGFR10.75531604
65CSK0.74634112
66NEK90.74541950
67MATK0.74326544
68ABL20.74220026
69RET0.73628037
70MAP3K80.73239566
71KDR0.72306738
72PRKG20.70889343
73MAP3K130.70850710
74RPS6KB20.70777721
75TYK20.70525489
76CDK120.70274777
77MAP2K20.67204280
78DYRK1B0.65566675
79ROCK20.64107010
80KSR20.63668124
81PTK2B0.62647640
82PDPK10.62032073
83ZAP700.61510483
84BLK0.60186527
85TGFBR10.59700417
86JAK10.59154649
87PAK30.58313569
88FGR0.58159252
89DAPK30.57930735
90FLT30.57580459
91EGFR0.56976289
92MAP3K10.56801830
93JAK30.56771657
94HCK0.55772731
95PIK3CG0.55207895
96NTRK10.53920738
97PAK10.53788583
98PRKD30.53283691
99PRKD10.53067915
100CHUK0.52354022
101MAPKAPK20.51629828
102ALK0.50442795
103IRAK20.49632349
104RPS6KL10.47480517
105RPS6KC10.47480517
106CAMKK10.47094602
107ROCK10.45469830
108GSK3A0.43393072
109FGFR30.42843166
110IKBKB0.42708389
111TAOK20.42383118
112SRC0.42087725
113INSR0.41780260
114MARK20.41303510
115ABL10.40472041
116TESK20.40094455
117CAMK1G0.39619761
118ICK0.39423718
119RPS6KA20.38531838
120MELK0.38427689
121BRAF0.36546069
122CAMK2G0.36255727
123CDK80.36005991
124MAP3K140.35887872
125MAP3K90.30073268
126MAPK110.28829887
127CLK10.26701952
128RPS6KA60.26098991
129HIPK20.25743917
130CDK70.25610381

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.89098860
2Focal adhesion_Homo sapiens_hsa045102.32533621
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.26327704
4Lysosome_Homo sapiens_hsa041422.24491172
5Amoebiasis_Homo sapiens_hsa051462.15175591
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.05466400
7Proteoglycans in cancer_Homo sapiens_hsa052052.03929086
8Bladder cancer_Homo sapiens_hsa052192.00742723
9Small cell lung cancer_Homo sapiens_hsa052221.93648673
10Adherens junction_Homo sapiens_hsa045201.90952423
11AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.89826453
12Malaria_Homo sapiens_hsa051441.85791837
13Leishmaniasis_Homo sapiens_hsa051401.73827910
14Chronic myeloid leukemia_Homo sapiens_hsa052201.69184222
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.67737059
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.63703211
17Shigellosis_Homo sapiens_hsa051311.63016921
18Phagosome_Homo sapiens_hsa041451.60945537
19Toxoplasmosis_Homo sapiens_hsa051451.60389294
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.53572165
21Osteoclast differentiation_Homo sapiens_hsa043801.43448635
22Pertussis_Homo sapiens_hsa051331.43314066
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.42461006
24Salmonella infection_Homo sapiens_hsa051321.40595917
25Galactose metabolism_Homo sapiens_hsa000521.39501612
26Regulation of actin cytoskeleton_Homo sapiens_hsa048101.38058812
27Apoptosis_Homo sapiens_hsa042101.37509249
28TNF signaling pathway_Homo sapiens_hsa046681.36609336
29MicroRNAs in cancer_Homo sapiens_hsa052061.36497397
30Other glycan degradation_Homo sapiens_hsa005111.35777530
31Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.35663222
32Tuberculosis_Homo sapiens_hsa051521.32218409
33Pancreatic cancer_Homo sapiens_hsa052121.27820655
34Pentose phosphate pathway_Homo sapiens_hsa000301.23406904
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19483500
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18314749
37Hippo signaling pathway_Homo sapiens_hsa043901.17764206
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.16183868
39Legionellosis_Homo sapiens_hsa051341.16178097
40VEGF signaling pathway_Homo sapiens_hsa043701.14446109
41Viral myocarditis_Homo sapiens_hsa054161.13034333
42Dilated cardiomyopathy_Homo sapiens_hsa054141.08672028
43Protein digestion and absorption_Homo sapiens_hsa049741.06358634
44Staphylococcus aureus infection_Homo sapiens_hsa051501.06210704
45Fructose and mannose metabolism_Homo sapiens_hsa000511.06103445
46Platelet activation_Homo sapiens_hsa046111.05254969
47Acute myeloid leukemia_Homo sapiens_hsa052211.02958774
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02361849
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01222281
50Renal cell carcinoma_Homo sapiens_hsa052111.00710828
51PI3K-Akt signaling pathway_Homo sapiens_hsa041511.00627648
52Melanoma_Homo sapiens_hsa052181.00048803
53TGF-beta signaling pathway_Homo sapiens_hsa043500.99866214
54HIF-1 signaling pathway_Homo sapiens_hsa040660.97674296
55Tight junction_Homo sapiens_hsa045300.95778431
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.95622367
57p53 signaling pathway_Homo sapiens_hsa041150.95272279
58Glioma_Homo sapiens_hsa052140.92312318
59Antigen processing and presentation_Homo sapiens_hsa046120.92210538
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.91374757
61Rheumatoid arthritis_Homo sapiens_hsa053230.91143812
62Endocytosis_Homo sapiens_hsa041440.89685213
63GnRH signaling pathway_Homo sapiens_hsa049120.88601591
64Rap1 signaling pathway_Homo sapiens_hsa040150.87664879
65Sphingolipid metabolism_Homo sapiens_hsa006000.86902899
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86648519
67mTOR signaling pathway_Homo sapiens_hsa041500.86638691
68Endometrial cancer_Homo sapiens_hsa052130.86276996
69Notch signaling pathway_Homo sapiens_hsa043300.85207564
70Hepatitis B_Homo sapiens_hsa051610.84809872
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84151664
72Caffeine metabolism_Homo sapiens_hsa002320.82515471
73Pathways in cancer_Homo sapiens_hsa052000.81374253
74N-Glycan biosynthesis_Homo sapiens_hsa005100.81255001
75Prostate cancer_Homo sapiens_hsa052150.78789514
76Viral carcinogenesis_Homo sapiens_hsa052030.78779181
77ErbB signaling pathway_Homo sapiens_hsa040120.77141671
78HTLV-I infection_Homo sapiens_hsa051660.73701597
79Axon guidance_Homo sapiens_hsa043600.73593244
80Thyroid cancer_Homo sapiens_hsa052160.73427087
81Colorectal cancer_Homo sapiens_hsa052100.73317172
82Prolactin signaling pathway_Homo sapiens_hsa049170.73125307
83Adipocytokine signaling pathway_Homo sapiens_hsa049200.72997120
84Insulin signaling pathway_Homo sapiens_hsa049100.72900349
85Renin-angiotensin system_Homo sapiens_hsa046140.71948548
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71086389
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69476391
88NF-kappa B signaling pathway_Homo sapiens_hsa040640.69078357
89B cell receptor signaling pathway_Homo sapiens_hsa046620.68590631
90Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68586398
91Insulin resistance_Homo sapiens_hsa049310.68570075
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.68235254
93Influenza A_Homo sapiens_hsa051640.67309598
94Vibrio cholerae infection_Homo sapiens_hsa051100.67180336
95Hepatitis C_Homo sapiens_hsa051600.65554409
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.65335472
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62682272
98Non-small cell lung cancer_Homo sapiens_hsa052230.61914457
99Hematopoietic cell lineage_Homo sapiens_hsa046400.61272953
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.60818140
101Gap junction_Homo sapiens_hsa045400.60518171
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60426963
103Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59057385
104Basal cell carcinoma_Homo sapiens_hsa052170.58824240
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.58482940
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57516376
107AMPK signaling pathway_Homo sapiens_hsa041520.57037679
108Sulfur metabolism_Homo sapiens_hsa009200.56797748
109Measles_Homo sapiens_hsa051620.56539983
110Mineral absorption_Homo sapiens_hsa049780.56369935
111Prion diseases_Homo sapiens_hsa050200.56181916
112Melanogenesis_Homo sapiens_hsa049160.52592428
113Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.52558682
114Estrogen signaling pathway_Homo sapiens_hsa049150.52128006
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50222518
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46520473
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45781992
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.45498996
119Biosynthesis of amino acids_Homo sapiens_hsa012300.45237285
120Complement and coagulation cascades_Homo sapiens_hsa046100.42492826
121Vitamin B6 metabolism_Homo sapiens_hsa007500.42225253

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