FAM131A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.24062605
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91433921
3synaptic vesicle maturation (GO:0016188)5.87232199
4locomotory exploration behavior (GO:0035641)5.74829790
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.63929137
6synaptic vesicle exocytosis (GO:0016079)5.58531586
7vocalization behavior (GO:0071625)5.53927969
8glutamate secretion (GO:0014047)5.52280302
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.47017746
10regulation of glutamate receptor signaling pathway (GO:1900449)5.31217804
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.28575930
12protein localization to synapse (GO:0035418)5.04075755
13regulation of synaptic vesicle exocytosis (GO:2000300)5.00505683
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.96849278
15regulation of neuronal synaptic plasticity (GO:0048168)4.93072102
16neuronal action potential propagation (GO:0019227)4.80535428
17exploration behavior (GO:0035640)4.76954067
18regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69373098
19regulation of synaptic vesicle transport (GO:1902803)4.60620263
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.57220140
21synaptic transmission, glutamatergic (GO:0035249)4.44457723
22glutamate receptor signaling pathway (GO:0007215)4.44300740
23neurotransmitter-gated ion channel clustering (GO:0072578)4.23059820
24neuron cell-cell adhesion (GO:0007158)4.20239751
25neurotransmitter secretion (GO:0007269)4.16986130
26long-term memory (GO:0007616)4.14765767
27regulation of excitatory postsynaptic membrane potential (GO:0060079)4.14429829
28regulation of synapse structural plasticity (GO:0051823)4.12796281
29neuron-neuron synaptic transmission (GO:0007270)4.09161540
30positive regulation of synapse maturation (GO:0090129)4.08741987
31behavioral response to nicotine (GO:0035095)4.07653227
32regulation of synaptic plasticity (GO:0048167)4.06694783
33dendritic spine morphogenesis (GO:0060997)4.04812319
34neuromuscular synaptic transmission (GO:0007274)4.01585885
35positive regulation of membrane potential (GO:0045838)3.97765974
36regulation of dendritic spine morphogenesis (GO:0061001)3.95452495
37long-term synaptic potentiation (GO:0060291)3.88016585
38regulation of postsynaptic membrane potential (GO:0060078)3.87695025
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83081235
40positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.81546306
41layer formation in cerebral cortex (GO:0021819)3.76568577
42synaptic vesicle endocytosis (GO:0048488)3.72165401
43cellular potassium ion homeostasis (GO:0030007)3.70848068
44proline transport (GO:0015824)3.63229492
45neuron recognition (GO:0008038)3.62596422
46gamma-aminobutyric acid signaling pathway (GO:0007214)3.60824872
47positive regulation of neurotransmitter secretion (GO:0001956)3.59883591
48G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.58629241
49dendritic spine organization (GO:0097061)3.56454844
50regulation of voltage-gated calcium channel activity (GO:1901385)3.51253823
51regulation of neurotransmitter secretion (GO:0046928)3.46929591
52positive regulation of dendritic spine morphogenesis (GO:0061003)3.42084890
53activation of protein kinase A activity (GO:0034199)3.40048545
54cell migration in hindbrain (GO:0021535)3.38301048
55central nervous system myelination (GO:0022010)3.38105249
56axon ensheathment in central nervous system (GO:0032291)3.38105249
57regulation of vesicle fusion (GO:0031338)3.37903507
58behavioral fear response (GO:0001662)3.37300095
59behavioral defense response (GO:0002209)3.37300095
60sodium ion export (GO:0071436)3.36764661
61negative regulation of synaptic transmission, GABAergic (GO:0032229)3.36223421
62positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.35007196
63neurotransmitter transport (GO:0006836)3.34935815
64axonal fasciculation (GO:0007413)3.34379328
65regulation of dendritic spine development (GO:0060998)3.33693249
66innervation (GO:0060384)3.32196435
67positive regulation of dendritic spine development (GO:0060999)3.31205347
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.30582530
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30551323
70neuromuscular process controlling balance (GO:0050885)3.27254896
71serotonin metabolic process (GO:0042428)3.26535444
72cerebellar granule cell differentiation (GO:0021707)3.24535182
73chemosensory behavior (GO:0007635)3.24326405
74postsynaptic membrane organization (GO:0001941)3.23959377
75membrane depolarization (GO:0051899)3.23297234
76cell communication by electrical coupling (GO:0010644)3.23243664
77transmission of nerve impulse (GO:0019226)3.22880564
78positive regulation of neurotransmitter transport (GO:0051590)3.21899792
79gamma-aminobutyric acid transport (GO:0015812)3.19286512
80fear response (GO:0042596)3.18721387
81regulation of synaptic transmission (GO:0050804)3.17491836
82startle response (GO:0001964)3.16432669
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.14754358
84regulation of neurotransmitter transport (GO:0051588)3.13684504
85positive regulation of synaptic transmission (GO:0050806)3.12354105
86regulation of synapse maturation (GO:0090128)3.12213993
87positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11807816
88learning (GO:0007612)3.11448415
89regulation of neurotransmitter levels (GO:0001505)3.11433459
90cellular response to ATP (GO:0071318)3.10154453
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.09925036
92presynaptic membrane assembly (GO:0097105)3.08965488
93primary amino compound metabolic process (GO:1901160)3.08902957
94vesicle transport along microtubule (GO:0047496)3.07063064
95detection of calcium ion (GO:0005513)3.06150565
96urinary tract smooth muscle contraction (GO:0014848)3.06148025
97long term synaptic depression (GO:0060292)3.05551609
98pyrimidine nucleobase catabolic process (GO:0006208)3.03668574
99potassium ion import (GO:0010107)3.03304718
100neuromuscular process controlling posture (GO:0050884)3.03291787
101regulation of female receptivity (GO:0045924)3.00852901
102response to histamine (GO:0034776)2.99909370
103regulation of glutamate secretion (GO:0014048)2.99523744
104membrane depolarization during action potential (GO:0086010)2.99138243
105synaptic transmission (GO:0007268)2.98179978
106regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97603943
107cerebellar Purkinje cell differentiation (GO:0021702)2.97519029
108response to gravity (GO:0009629)2.97031711
109positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.95242728
110neuronal ion channel clustering (GO:0045161)2.94919554
111presynaptic membrane organization (GO:0097090)2.93658045
112amino acid import (GO:0043090)2.92818204
113acidic amino acid transport (GO:0015800)2.91554988
114negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91259157
115auditory behavior (GO:0031223)2.88271850
116positive regulation of fibroblast migration (GO:0010763)2.87848217
117synapse assembly (GO:0007416)2.86431380
118social behavior (GO:0035176)2.86248451
119intraspecies interaction between organisms (GO:0051703)2.86248451
120L-amino acid import (GO:0043092)2.85962759
121cellular potassium ion transport (GO:0071804)2.79820623
122potassium ion transmembrane transport (GO:0071805)2.79820623
123neuromuscular process (GO:0050905)2.79465197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.30807440
2GBX2_23144817_ChIP-Seq_PC3_Human3.40924614
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22137703
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.17007593
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12580735
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.85157781
7REST_21632747_ChIP-Seq_MESCs_Mouse2.84719145
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.81034330
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.81034330
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.74314571
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.73860850
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61314736
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60075044
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59970593
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.54815666
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51125496
17DROSHA_22980978_ChIP-Seq_HELA_Human2.48973906
18REST_18959480_ChIP-ChIP_MESCs_Mouse2.36716435
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.32999679
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32220621
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.31016484
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.28120129
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.26180267
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.10683488
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.91724825
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90928508
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.83975646
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68921499
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68781655
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67855508
31AR_21572438_ChIP-Seq_LNCaP_Human1.67738771
32SMAD4_21799915_ChIP-Seq_A2780_Human1.60360761
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.57502118
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.56260394
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.45142634
36ZNF274_21170338_ChIP-Seq_K562_Hela1.41384215
37TAF15_26573619_Chip-Seq_HEK293_Human1.40518510
38PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38473532
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.36644522
40NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36592225
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34440454
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34328447
43P300_19829295_ChIP-Seq_ESCs_Human1.31663763
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29591173
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29047522
46DNAJC2_21179169_ChIP-ChIP_NT2_Human1.28896307
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.27154149
48AR_25329375_ChIP-Seq_VCAP_Human1.25943457
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.25860610
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25497880
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24233347
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.23516418
53P68_20966046_ChIP-Seq_HELA_Human1.20105039
54CBX2_27304074_Chip-Seq_ESCs_Mouse1.15914295
55AR_19668381_ChIP-Seq_PC3_Human1.15578998
56TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15115700
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14053751
58TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13678823
59* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13162222
60STAT3_23295773_ChIP-Seq_U87_Human1.11308374
61OCT4_19829295_ChIP-Seq_ESCs_Human1.11034296
62TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10884305
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.10707699
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08109961
65RING1B_27294783_Chip-Seq_NPCs_Mouse1.08042440
66* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06995255
67PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06782452
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06645151
69ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06356649
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05079303
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04524063
72TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04457122
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.03010628
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02154651
75MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02082932
76SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02069809
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01672636
78TCF4_23295773_ChIP-Seq_U87_Human1.00898452
79SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00732327
80VDR_22108803_ChIP-Seq_LS180_Human1.00305590
81SMC4_20622854_ChIP-Seq_HELA_Human1.00300936
82KDM2B_26808549_Chip-Seq_K562_Human1.00247271
83PRDM14_20953172_ChIP-Seq_ESCs_Human0.99491652
84PIAS1_25552417_ChIP-Seq_VCAP_Human0.98494970
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97619909
86RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97512753
87ARNT_22903824_ChIP-Seq_MCF-7_Human0.96237307
88RNF2_27304074_Chip-Seq_NSC_Mouse0.96084805
89ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95815185
90YAP1_20516196_ChIP-Seq_MESCs_Mouse0.95776665
91ERA_21632823_ChIP-Seq_H3396_Human0.93144450
92LXR_22292898_ChIP-Seq_THP-1_Human0.92764600
93IGF1R_20145208_ChIP-Seq_DFB_Human0.92719060
94SMAD3_21741376_ChIP-Seq_HESCs_Human0.92533300
95MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.92497535
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.92453761
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92034937
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92034937
99CTCF_20526341_ChIP-Seq_ESCs_Human0.92015740
100KLF4_19829295_ChIP-Seq_ESCs_Human0.91317903
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90633424
102NR3C1_21868756_ChIP-Seq_MCF10A_Human0.90478008
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.89979672
104THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89315613
105FUS_26573619_Chip-Seq_HEK293_Human0.89188793
106RUNX2_22187159_ChIP-Seq_PCA_Human0.88935477
107UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88719592
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.88695220
109* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88684049
110CTCF_27219007_Chip-Seq_Bcells_Human0.88659378
111TET1_21490601_ChIP-Seq_MESCs_Mouse0.86967743
112OCT4_20526341_ChIP-Seq_ESCs_Human0.86907523
113TP53_20018659_ChIP-ChIP_R1E_Mouse0.86500096
114AHR_22903824_ChIP-Seq_MCF-7_Human0.85544270
115RXR_22108803_ChIP-Seq_LS180_Human0.85494298
116TP53_16413492_ChIP-PET_HCT116_Human0.85478156
117TAF2_19829295_ChIP-Seq_ESCs_Human0.85441203
118BCL6_27268052_Chip-Seq_Bcells_Human0.85380014
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84983576
120JUN_21703547_ChIP-Seq_K562_Human0.84474277
121SA1_27219007_Chip-Seq_Bcells_Human0.84127154
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83877017
123EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.83640343
124E2F1_20622854_ChIP-Seq_HELA_Human0.80266775
125NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.80158639
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79992881
127TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.79562443
128MYC_19829295_ChIP-Seq_ESCs_Human0.77232997
129PHF8_20622854_ChIP-Seq_HELA_Human0.75962604
130* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.75692799
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.73902209
132ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73627852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.57307821
2MP0003880_abnormal_central_pattern5.27282221
3MP0003635_abnormal_synaptic_transmissio4.35536748
4MP0004270_analgesia3.82846155
5MP0002063_abnormal_learning/memory/cond3.55217145
6MP0009745_abnormal_behavioral_response3.51441830
7MP0002064_seizures3.21722135
8MP0001968_abnormal_touch/_nociception2.93964320
9MP0002572_abnormal_emotion/affect_behav2.85142899
10MP0009046_muscle_twitch2.71316784
11MP0002272_abnormal_nervous_system2.57130453
12MP0002736_abnormal_nociception_after2.43686513
13MP0001486_abnormal_startle_reflex2.42428639
14MP0002734_abnormal_mechanical_nocicepti2.42059908
15MP0002822_catalepsy2.37615615
16MP0005423_abnormal_somatic_nervous2.34976851
17MP0001501_abnormal_sleep_pattern2.30924567
18MP0002735_abnormal_chemical_nociception2.22598165
19MP0001440_abnormal_grooming_behavior2.22569211
20MP0009780_abnormal_chondrocyte_physiolo2.13135502
21MP0003329_amyloid_beta_deposits2.11046002
22MP0001986_abnormal_taste_sensitivity2.10047603
23MP0002733_abnormal_thermal_nociception1.86618669
24MP0004858_abnormal_nervous_system1.85838808
25MP0002638_abnormal_pupillary_reflex1.84575005
26MP0002067_abnormal_sensory_capabilities1.83476680
27MP0001970_abnormal_pain_threshold1.83178077
28MP0008569_lethality_at_weaning1.80913920
29MP0004811_abnormal_neuron_physiology1.76143326
30MP0000778_abnormal_nervous_system1.74251331
31MP0003879_abnormal_hair_cell1.71472669
32MP0002909_abnormal_adrenal_gland1.68107435
33MP0002184_abnormal_innervation1.66976159
34MP0002557_abnormal_social/conspecific_i1.63457911
35MP0003787_abnormal_imprinting1.57362713
36MP0005386_behavior/neurological_phenoty1.53371680
37MP0004924_abnormal_behavior1.53371680
38MP0006276_abnormal_autonomic_nervous1.46839276
39MP0005646_abnormal_pituitary_gland1.46607723
40MP0000955_abnormal_spinal_cord1.46181279
41MP0003136_yellow_coat_color1.40154317
42MP0002066_abnormal_motor_capabilities/c1.39444629
43MP0002837_dystrophic_cardiac_calcinosis1.37656004
44MP0001984_abnormal_olfaction1.36926629
45MP0000751_myopathy1.36568772
46MP0002882_abnormal_neuron_morphology1.35551142
47MP0003633_abnormal_nervous_system1.35359598
48MP0005171_absent_coat_pigmentation1.34429375
49MP0004885_abnormal_endolymph1.28386511
50MP0002653_abnormal_ependyma_morphology1.25538627
51MP0001502_abnormal_circadian_rhythm1.25173440
52MP0001905_abnormal_dopamine_level1.24768035
53MP0004147_increased_porphyrin_level1.20575299
54MP0004145_abnormal_muscle_electrophysio1.20109702
55MP0003631_nervous_system_phenotype1.14128928
56MP0005174_abnormal_tail_pigmentation1.14097036
57MP0005645_abnormal_hypothalamus_physiol1.14016754
58MP0001529_abnormal_vocalization1.13957923
59MP0003075_altered_response_to1.12640307
60MP0002152_abnormal_brain_morphology1.04879156
61MP0003122_maternal_imprinting0.99700035
62MP0000604_amyloidosis0.96796383
63MP0008875_abnormal_xenobiotic_pharmacok0.95831407
64MP0008874_decreased_physiological_sensi0.95011226
65MP0004133_heterotaxia0.94790727
66MP0002069_abnormal_eating/drinking_beha0.94519959
67MP0004142_abnormal_muscle_tone0.94462619
68MP0004510_myositis0.93607205
69MP0004484_altered_response_of0.93477910
70MP0004215_abnormal_myocardial_fiber0.92382948
71MP0005535_abnormal_body_temperature0.89734256
72MP0010386_abnormal_urinary_bladder0.88658059
73MP0000013_abnormal_adipose_tissue0.88062976
74MP0004085_abnormal_heartbeat0.86912998
75MP0010234_abnormal_vibrissa_follicle0.86397216
76MP0008872_abnormal_physiological_respon0.85884057
77MP0002229_neurodegeneration0.84731854
78MP0000026_abnormal_inner_ear0.83919748
79MP0008961_abnormal_basal_metabolism0.83175834
80MP0003646_muscle_fatigue0.80589601
81MP0001188_hyperpigmentation0.78506316
82MP0001963_abnormal_hearing_physiology0.77048205
83MP0008877_abnormal_DNA_methylation0.75203746
84MP0003632_abnormal_nervous_system0.74505810
85MP0005377_hearing/vestibular/ear_phenot0.74188299
86MP0003878_abnormal_ear_physiology0.74188299
87MP0005253_abnormal_eye_physiology0.74187457
88MP0004742_abnormal_vestibular_system0.72765277
89MP0005551_abnormal_eye_electrophysiolog0.72359853
90MP0001177_atelectasis0.72225252
91MP0003634_abnormal_glial_cell0.71865532
92MP0004233_abnormal_muscle_weight0.71120534
93MP0006072_abnormal_retinal_apoptosis0.69604416
94MP0003283_abnormal_digestive_organ0.68924187
95MP0002876_abnormal_thyroid_physiology0.68917815
96MP0001664_abnormal_digestion0.67557972
97MP0005167_abnormal_blood-brain_barrier0.65402384
98MP0002928_abnormal_bile_duct0.65372304
99MP0003123_paternal_imprinting0.65184290
100MP0002234_abnormal_pharynx_morphology0.65177523
101MP0000920_abnormal_myelination0.64918274
102MP0005623_abnormal_meninges_morphology0.64213174
103MP0003690_abnormal_glial_cell0.64200956
104MP0003137_abnormal_impulse_conducting0.63959488
105MP0002752_abnormal_somatic_nervous0.63224686
106MP0002102_abnormal_ear_morphology0.62951233
107MP0005499_abnormal_olfactory_system0.62390277
108MP0005394_taste/olfaction_phenotype0.62390277
109MP0001485_abnormal_pinna_reflex0.62218000
110MP0004130_abnormal_muscle_cell0.61297950
111MP0002090_abnormal_vision0.60083645
112MP0000631_abnormal_neuroendocrine_gland0.59568265
113MP0001765_abnormal_ion_homeostasis0.57723677
114MP0004043_abnormal_pH_regulation0.57036049
115MP0005620_abnormal_muscle_contractility0.55044478
116MP0003938_abnormal_ear_development0.50945616
117MP0004036_abnormal_muscle_relaxation0.50674032
118MP0005187_abnormal_penis_morphology0.50209174
119MP0000747_muscle_weakness0.48712767

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.56102694
2Myokymia (HP:0002411)7.33742827
3Focal seizures (HP:0007359)6.01762788
4Visual hallucinations (HP:0002367)5.92956940
5Epileptic encephalopathy (HP:0200134)5.39058028
6Atonic seizures (HP:0010819)5.02124955
7Febrile seizures (HP:0002373)4.52068086
8Absence seizures (HP:0002121)4.50946738
9Dialeptic seizures (HP:0011146)4.13829533
10Progressive cerebellar ataxia (HP:0002073)4.08782470
11Generalized tonic-clonic seizures (HP:0002069)4.00769011
12Action tremor (HP:0002345)3.67863892
13Impaired vibration sensation in the lower limbs (HP:0002166)3.58645775
14Hyperventilation (HP:0002883)3.57602733
15Broad-based gait (HP:0002136)3.56028700
16Amblyopia (HP:0000646)3.45884942
17Poor eye contact (HP:0000817)3.42328946
18Supranuclear gaze palsy (HP:0000605)3.41378779
19Depression (HP:0000716)3.34525485
20Abnormality of the lower motor neuron (HP:0002366)3.27775322
21Gaze-evoked nystagmus (HP:0000640)3.26286330
22Dysmetria (HP:0001310)3.22249193
23Akinesia (HP:0002304)3.21222939
24Anxiety (HP:0000739)3.10122928
25Ankle clonus (HP:0011448)3.08739611
26Dysdiadochokinesis (HP:0002075)3.08567533
27Congenital stationary night blindness (HP:0007642)3.07902782
28Impaired social interactions (HP:0000735)3.01155259
29Abnormal social behavior (HP:0012433)3.01155259
30Cerebral inclusion bodies (HP:0100314)3.00814437
31Abnormal eating behavior (HP:0100738)3.00689323
32Limb dystonia (HP:0002451)3.00379319
33Postural instability (HP:0002172)2.89051034
34Urinary bladder sphincter dysfunction (HP:0002839)2.87189539
35Truncal ataxia (HP:0002078)2.86738411
36Epileptiform EEG discharges (HP:0011182)2.76193644
37Excessive salivation (HP:0003781)2.68369925
38Drooling (HP:0002307)2.68369925
39Neurofibrillary tangles (HP:0002185)2.64968843
40Mutism (HP:0002300)2.64496716
41Impaired smooth pursuit (HP:0007772)2.60161658
42Urinary urgency (HP:0000012)2.57435991
43EEG with generalized epileptiform discharges (HP:0011198)2.54538193
44Decreased central vision (HP:0007663)2.51880430
45Ventricular fibrillation (HP:0001663)2.51693508
46Stereotypic behavior (HP:0000733)2.51575687
47Hemiparesis (HP:0001269)2.48597938
48Attenuation of retinal blood vessels (HP:0007843)2.47994066
49Papilledema (HP:0001085)2.46551562
50Bradykinesia (HP:0002067)2.46073075
51Focal dystonia (HP:0004373)2.46040265
52Delusions (HP:0000746)2.45948147
53Impaired vibratory sensation (HP:0002495)2.45400452
54Torticollis (HP:0000473)2.41963854
55Annular pancreas (HP:0001734)2.41715381
56Hypsarrhythmia (HP:0002521)2.40859869
57Abnormality of binocular vision (HP:0011514)2.40239246
58Diplopia (HP:0000651)2.40239246
59Genetic anticipation (HP:0003743)2.39673784
60Polydipsia (HP:0001959)2.38870539
61Abnormal drinking behavior (HP:0030082)2.38870539
62Progressive inability to walk (HP:0002505)2.38318971
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.37779191
64Absent/shortened dynein arms (HP:0200106)2.37779191
65Bundle branch block (HP:0011710)2.37320406
66Type II lissencephaly (HP:0007260)2.36166566
67Spastic gait (HP:0002064)2.35043900
68Molar tooth sign on MRI (HP:0002419)2.34887852
69Abnormality of midbrain morphology (HP:0002418)2.34887852
70Intention tremor (HP:0002080)2.32603857
71Turricephaly (HP:0000262)2.31602965
72Megalencephaly (HP:0001355)2.27822794
73Fetal akinesia sequence (HP:0001989)2.26839484
74Dysmetric saccades (HP:0000641)2.26626522
75Cerebral hypomyelination (HP:0006808)2.25125140
76Rib fusion (HP:0000902)2.24344635
77Sleep apnea (HP:0010535)2.24319881
78Insidious onset (HP:0003587)2.23723309
79Termporal pattern (HP:0011008)2.23723309
80Absent speech (HP:0001344)2.23300445
81Abnormality of ocular smooth pursuit (HP:0000617)2.22193208
82Generalized myoclonic seizures (HP:0002123)2.21809584
83Abnormal respiratory motile cilium morphology (HP:0005938)2.21256046
84Abnormal respiratory epithelium morphology (HP:0012253)2.21256046
85Prolonged QT interval (HP:0001657)2.18710240
86Scanning speech (HP:0002168)2.17107982
87Morphological abnormality of the pyramidal tract (HP:0002062)2.15711672
88Retinal dysplasia (HP:0007973)2.15034326
89Nephronophthisis (HP:0000090)2.14305404
90Hemiplegia (HP:0002301)2.14156980
91Rapidly progressive (HP:0003678)2.13464862
92Status epilepticus (HP:0002133)2.13290861
93Inability to walk (HP:0002540)2.10665548
94Incomplete penetrance (HP:0003829)2.08508124
95Lower limb muscle weakness (HP:0007340)2.06033093
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01722801
97Degeneration of the lateral corticospinal tracts (HP:0002314)2.01722801
98Craniofacial dystonia (HP:0012179)2.01502782
99Gait imbalance (HP:0002141)2.00151726
100Dyskinesia (HP:0100660)1.98201663
101Gait ataxia (HP:0002066)1.98024159
102Testicular atrophy (HP:0000029)1.96773833
103Pheochromocytoma (HP:0002666)1.95140697
104Pointed chin (HP:0000307)1.93188480
105Progressive microcephaly (HP:0000253)1.91620174
106Thickened helices (HP:0000391)1.91245784
107Lower limb asymmetry (HP:0100559)1.91178442
108Pancreatic cysts (HP:0001737)1.91072154
109Obstructive sleep apnea (HP:0002870)1.90643834
110Chronic hepatic failure (HP:0100626)1.90045898
111Exercise-induced myalgia (HP:0003738)1.89256193
112Polyphagia (HP:0002591)1.89255231
113Abnormality of the corticospinal tract (HP:0002492)1.88705681
114Psychosis (HP:0000709)1.88029736
115Sudden death (HP:0001699)1.85787644
116Bony spicule pigmentary retinopathy (HP:0007737)1.84447768
117True hermaphroditism (HP:0010459)1.82910545
118Spastic tetraparesis (HP:0001285)1.82631352
119Clonus (HP:0002169)1.82456366
120Pancreatic fibrosis (HP:0100732)1.81624745
121Abnormality of salivation (HP:0100755)1.80907374
122Anosmia (HP:0000458)1.79306509
123Blue irides (HP:0000635)1.77337053
124Rigidity (HP:0002063)1.77057428
125Insomnia (HP:0100785)1.77014731
126Abnormal EKG (HP:0003115)1.76439683
127Amyotrophic lateral sclerosis (HP:0007354)1.75834513
128Deep palmar crease (HP:0006191)1.75531530
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.74609649
130Lower limb amyotrophy (HP:0007210)1.74020553
131Agitation (HP:0000713)1.70244337
132Syncope (HP:0001279)1.69736945
133Neuronal loss in central nervous system (HP:0002529)1.69000164
134Protruding tongue (HP:0010808)1.68022763
135Neuroendocrine neoplasm (HP:0100634)1.66977338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.04774733
2NTRK34.59090334
3MAP3K93.90667333
4DAPK22.84772701
5MAP3K42.67452885
6MINK12.61301551
7KSR22.57447530
8PRKD32.42374448
9MAPK152.41424317
10RIPK42.25946128
11MAP2K72.24648217
12PAK62.24110869
13MAP3K122.21202848
14ARAF2.08435095
15MARK12.05954605
16CASK1.95512767
17KSR11.92929720
18MAP2K41.88588817
19DAPK11.88503343
20MAP3K131.85961014
21PLK21.75362137
22WNK41.71404323
23PRPF4B1.67476082
24CAMKK11.64937486
25NTRK21.60663282
26CDK191.58710971
27GRK51.58357606
28FRK1.56092929
29CDK51.49460928
30PTK2B1.48613875
31NTRK11.45461604
32ADRBK21.42057708
33MAP3K111.33962433
34PNCK1.31357488
35STK381.28623598
36MAP2K61.25222349
37FES1.22750362
38PRKCG1.22214190
39RAF11.18451530
40MAP3K21.17253540
41SIK21.13801307
42TNIK1.13148134
43NME11.06881958
44CAMK2A1.05002134
45CAMK11.03441626
46MAPK131.02887440
47TYRO31.01893075
48DYRK20.99401082
49BMPR20.97208348
50CAMK2B0.93279866
51PKN10.91899314
52UHMK10.91469562
53PHKG20.90178361
54PHKG10.90178361
55CDK180.88615545
56GRK10.87186820
57CDK150.85264538
58CDK140.81473450
59ADRBK10.80158285
60TAOK10.80043980
61PAK30.79488303
62TLK10.79234715
63OXSR10.79083762
64MAP3K10.79041589
65PINK10.78942828
66PDK10.77020827
67CAMKK20.75408740
68LATS20.75199729
69CDK11A0.74286384
70MAP4K20.73923538
71STK110.73176805
72SGK2230.73035169
73SGK4940.73035169
74PRKCH0.70928892
75PDPK10.69373751
76FGR0.69096255
77DYRK1A0.69003602
78LMTK20.64212248
79RET0.63915509
80WNK30.63645636
81SGK10.63045625
82BRAF0.62018744
83FER0.61500033
84MAP3K70.61188127
85BMPR1B0.60296663
86DAPK30.60120968
87MARK20.54342172
88CSNK1G30.53776318
89CSNK1A1L0.53466108
90SGK20.53415478
91CCNB10.52064045
92MAP2K10.50335291
93SIK30.49833570
94MOS0.49610452
95DMPK0.49534142
96CAMK2D0.49196708
97FGFR20.48562108
98CAMK1D0.47430254
99ALK0.46129353
100PRKCE0.45470939
101NEK10.44931114
102SGK30.44893049
103CAMK40.44698631
104PRKD20.44309059
105IRAK20.44138954
106INSRR0.44100890
107ACVR1B0.43081531
108CAMK2G0.42692981
109PRKCA0.42580914
110MAPKAPK50.42475897
111STK390.41802329
112RPS6KA30.41741649
113MAP3K60.41678663
114TNK20.41558255
115PRKACA0.41218223
116PRKCZ0.41097223
117PDK40.38705223
118PDK30.38705223
119ERBB20.38581204
120MAPK100.37521827
121MUSK0.37212075
122FYN0.36243785
123TAOK30.36008795
124MAPK120.34637102
125CSNK1G20.33090806
126NEK60.32064840
127CSNK1D0.30774082
128MAPK80.30185813
129WNK10.29989423
130ROCK20.29494107
131RPS6KA20.29055732
132CSNK1G10.28854760
133CDC42BPA0.28441991

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67316651
2Synaptic vesicle cycle_Homo sapiens_hsa047213.27136471
3Long-term potentiation_Homo sapiens_hsa047202.97262971
4Olfactory transduction_Homo sapiens_hsa047402.80801168
5Circadian entrainment_Homo sapiens_hsa047132.77533096
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.69201894
7Amphetamine addiction_Homo sapiens_hsa050312.61453876
8Glutamatergic synapse_Homo sapiens_hsa047242.58502782
9GABAergic synapse_Homo sapiens_hsa047272.49201802
10Morphine addiction_Homo sapiens_hsa050322.38968613
11Salivary secretion_Homo sapiens_hsa049702.25301977
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23799810
13Dopaminergic synapse_Homo sapiens_hsa047282.11193644
14Insulin secretion_Homo sapiens_hsa049112.10986048
15Gastric acid secretion_Homo sapiens_hsa049712.00861184
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.92833402
17Cholinergic synapse_Homo sapiens_hsa047251.84960571
18Oxytocin signaling pathway_Homo sapiens_hsa049211.79982243
19Calcium signaling pathway_Homo sapiens_hsa040201.74509350
20Long-term depression_Homo sapiens_hsa047301.73346013
21Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72174461
22Collecting duct acid secretion_Homo sapiens_hsa049661.70354236
23Renin secretion_Homo sapiens_hsa049241.70299366
24Taste transduction_Homo sapiens_hsa047421.69875886
25GnRH signaling pathway_Homo sapiens_hsa049121.58873785
26Serotonergic synapse_Homo sapiens_hsa047261.56065397
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41161925
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36868252
29Cocaine addiction_Homo sapiens_hsa050301.36773456
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32270039
31Gap junction_Homo sapiens_hsa045401.29281270
32cAMP signaling pathway_Homo sapiens_hsa040241.28601526
33Glioma_Homo sapiens_hsa052141.24595148
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20279497
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17250176
36Estrogen signaling pathway_Homo sapiens_hsa049151.14427104
37Cardiac muscle contraction_Homo sapiens_hsa042601.14060443
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12058903
39Type II diabetes mellitus_Homo sapiens_hsa049301.10626060
40Melanogenesis_Homo sapiens_hsa049161.09518962
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08713241
42Vibrio cholerae infection_Homo sapiens_hsa051101.06069324
43Axon guidance_Homo sapiens_hsa043601.02893044
44ErbB signaling pathway_Homo sapiens_hsa040121.00920493
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00808623
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.99716745
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.97462987
48Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.95370784
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94896430
50Oocyte meiosis_Homo sapiens_hsa041140.92602643
51Pancreatic secretion_Homo sapiens_hsa049720.87296951
52Dorso-ventral axis formation_Homo sapiens_hsa043200.83935304
53Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.83907702
54Phospholipase D signaling pathway_Homo sapiens_hsa040720.82363260
55VEGF signaling pathway_Homo sapiens_hsa043700.82172115
56Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81559083
57Dilated cardiomyopathy_Homo sapiens_hsa054140.78008507
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76651324
59Glucagon signaling pathway_Homo sapiens_hsa049220.75343972
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75252329
61Choline metabolism in cancer_Homo sapiens_hsa052310.74954715
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.74931678
63Nitrogen metabolism_Homo sapiens_hsa009100.74163396
64Thyroid hormone synthesis_Homo sapiens_hsa049180.72858617
65Linoleic acid metabolism_Homo sapiens_hsa005910.72564924
66Ether lipid metabolism_Homo sapiens_hsa005650.72373015
67Sulfur relay system_Homo sapiens_hsa041220.71996429
68MAPK signaling pathway_Homo sapiens_hsa040100.68422722
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66388854
70Phototransduction_Homo sapiens_hsa047440.65673994
71Vitamin B6 metabolism_Homo sapiens_hsa007500.62279037
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.62148239
73Alzheimers disease_Homo sapiens_hsa050100.61793999
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61039214
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59488361
76Ras signaling pathway_Homo sapiens_hsa040140.55674993
77Regulation of autophagy_Homo sapiens_hsa041400.55489099
78Rap1 signaling pathway_Homo sapiens_hsa040150.53559957
79Inositol phosphate metabolism_Homo sapiens_hsa005620.52257623
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.49964223
81Circadian rhythm_Homo sapiens_hsa047100.49107049
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48886241
83African trypanosomiasis_Homo sapiens_hsa051430.47431378
84Parkinsons disease_Homo sapiens_hsa050120.47139977
85Endocytosis_Homo sapiens_hsa041440.46781677
86ABC transporters_Homo sapiens_hsa020100.46519960
87Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46310051
88mTOR signaling pathway_Homo sapiens_hsa041500.43970992
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43689485
90Prion diseases_Homo sapiens_hsa050200.43537071
91Type I diabetes mellitus_Homo sapiens_hsa049400.42085234
92Non-small cell lung cancer_Homo sapiens_hsa052230.40730235
93Oxidative phosphorylation_Homo sapiens_hsa001900.40456025
94Wnt signaling pathway_Homo sapiens_hsa043100.38936734
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.38853741
96Insulin signaling pathway_Homo sapiens_hsa049100.38540940
97Mineral absorption_Homo sapiens_hsa049780.38493265
98Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38148876
99Bile secretion_Homo sapiens_hsa049760.37780037
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36944362
101Alcoholism_Homo sapiens_hsa050340.36372925
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35553212
103Renal cell carcinoma_Homo sapiens_hsa052110.35292856
104Fatty acid biosynthesis_Homo sapiens_hsa000610.33956786
105Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33390470
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.32737739
107Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31950300
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31365338
109Butanoate metabolism_Homo sapiens_hsa006500.30871591
110Histidine metabolism_Homo sapiens_hsa003400.28612029
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28331940
112Endometrial cancer_Homo sapiens_hsa052130.27774820
113Chemokine signaling pathway_Homo sapiens_hsa040620.26798701
114Huntingtons disease_Homo sapiens_hsa050160.26595668
115Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25742814
116Arginine and proline metabolism_Homo sapiens_hsa003300.25656919
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25337617
118Ovarian steroidogenesis_Homo sapiens_hsa049130.25296077
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24920134
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.24775313

Most similar genes based on co-expression Upload to Enrichr

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