FAM131B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.32168090
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06291470
3locomotory exploration behavior (GO:0035641)6.02788030
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.69048900
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.57687027
6vocalization behavior (GO:0071625)5.34640311
7synaptic vesicle exocytosis (GO:0016079)5.25996783
8glutamate secretion (GO:0014047)5.19570584
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.14001118
10regulation of synaptic vesicle exocytosis (GO:2000300)5.10716171
11neuronal action potential propagation (GO:0019227)5.06870473
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.85598987
13regulation of glutamate receptor signaling pathway (GO:1900449)4.70790077
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.65407465
15layer formation in cerebral cortex (GO:0021819)4.57595712
16central nervous system myelination (GO:0022010)4.56311759
17axon ensheathment in central nervous system (GO:0032291)4.56311759
18regulation of neuronal synaptic plasticity (GO:0048168)4.51640236
19protein localization to synapse (GO:0035418)4.50649381
20neurotransmitter secretion (GO:0007269)4.49360106
21regulation of synaptic vesicle transport (GO:1902803)4.48598980
22regulation of long-term neuronal synaptic plasticity (GO:0048169)4.48248798
23exploration behavior (GO:0035640)4.47593441
24regulation of synapse structural plasticity (GO:0051823)4.38482655
25dendritic spine morphogenesis (GO:0060997)4.37946502
26gamma-aminobutyric acid transport (GO:0015812)4.34044375
27synaptic transmission, glutamatergic (GO:0035249)4.24438843
28neuron cell-cell adhesion (GO:0007158)4.17211110
29amino acid import (GO:0043090)4.15932434
30glutamate receptor signaling pathway (GO:0007215)4.12953770
31presynaptic membrane organization (GO:0097090)4.09699535
32presynaptic membrane assembly (GO:0097105)4.08691546
33cellular potassium ion homeostasis (GO:0030007)4.03207557
34neuron-neuron synaptic transmission (GO:0007270)3.99516946
35long-term memory (GO:0007616)3.97739570
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.95390837
37potassium ion homeostasis (GO:0055075)3.94140685
38neurotransmitter-gated ion channel clustering (GO:0072578)3.86545935
39sodium ion export (GO:0071436)3.81590931
40regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81492223
41neuromuscular process controlling balance (GO:0050885)3.80784263
42positive regulation of membrane potential (GO:0045838)3.80382109
43regulation of synapse maturation (GO:0090128)3.79873579
44glycine transport (GO:0015816)3.72071512
45regulation of dendritic spine morphogenesis (GO:0061001)3.67707038
46proline transport (GO:0015824)3.67245693
47positive regulation of dendritic spine morphogenesis (GO:0061003)3.66080457
48neurotransmitter transport (GO:0006836)3.65198151
49cerebellar Purkinje cell differentiation (GO:0021702)3.62207707
50transmission of nerve impulse (GO:0019226)3.57814283
51regulation of postsynaptic membrane potential (GO:0060078)3.57583553
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.57472080
53regulation of synaptic plasticity (GO:0048167)3.54854644
54auditory behavior (GO:0031223)3.53898897
55L-amino acid import (GO:0043092)3.53470428
56activation of protein kinase A activity (GO:0034199)3.51901737
57positive regulation of synapse maturation (GO:0090129)3.50200857
58dendrite morphogenesis (GO:0048813)3.48795885
59establishment of mitochondrion localization (GO:0051654)3.47694467
60regulation of neurotransmitter secretion (GO:0046928)3.46108665
61neuron recognition (GO:0008038)3.39794694
62regulation of neurotransmitter levels (GO:0001505)3.39670943
63prepulse inhibition (GO:0060134)3.38431973
64neuromuscular process controlling posture (GO:0050884)3.37609351
65cerebellar granule cell differentiation (GO:0021707)3.37487551
66cellular sodium ion homeostasis (GO:0006883)3.35648437
67gamma-aminobutyric acid signaling pathway (GO:0007214)3.35555681
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30903726
69synaptic vesicle endocytosis (GO:0048488)3.29475363
70negative regulation of dendrite morphogenesis (GO:0050774)3.29029112
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.27606967
72regulation of synaptic transmission, glutamatergic (GO:0051966)3.27551879
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.26391801
74neuromuscular synaptic transmission (GO:0007274)3.25163152
75response to auditory stimulus (GO:0010996)3.24746599
76long-term synaptic potentiation (GO:0060291)3.24262800
77neuronal ion channel clustering (GO:0045161)3.24205222
78regulation of neurotransmitter transport (GO:0051588)3.23289843
79regulation of voltage-gated calcium channel activity (GO:1901385)3.21236737
80membrane depolarization during action potential (GO:0086010)3.20368316
81membrane depolarization (GO:0051899)3.19771508
82negative regulation of synaptic transmission, GABAergic (GO:0032229)3.18474861
83axonal fasciculation (GO:0007413)3.18136300
84G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.17555386
85adult walking behavior (GO:0007628)3.17231664
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.16346837
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.15628500
88neurotransmitter uptake (GO:0001504)3.14554447
89cerebellar Purkinje cell layer development (GO:0021680)3.14164106
90regulation of vesicle fusion (GO:0031338)3.13722642
91membrane hyperpolarization (GO:0060081)3.13534553
92positive regulation of synaptic transmission, GABAergic (GO:0032230)3.13104515
93acidic amino acid transport (GO:0015800)3.12688077
94dendritic spine organization (GO:0097061)3.11490082
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11280091
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.11238741
97regulation of dendritic spine development (GO:0060998)3.10309122
98cell differentiation in hindbrain (GO:0021533)3.09629128
99regulation of ARF protein signal transduction (GO:0032012)3.09213897
100neuromuscular process (GO:0050905)3.08815313
101positive regulation of dendritic spine development (GO:0060999)3.06681959
102cell migration in hindbrain (GO:0021535)3.06224688
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04230718
104positive regulation of neurotransmitter secretion (GO:0001956)3.03094627
105positive regulation of neurotransmitter transport (GO:0051590)3.01492405
106cell communication by electrical coupling (GO:0010644)3.01489875
107cytoskeletal anchoring at plasma membrane (GO:0007016)3.01267434
108postsynaptic membrane organization (GO:0001941)2.99867688
109learning (GO:0007612)2.98207818
110regulation of synaptic transmission (GO:0050804)2.96828902
111regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.96518445
112vesicle transport along microtubule (GO:0047496)2.96011519
113potassium ion import (GO:0010107)2.95976803
114establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93846309
115synapse assembly (GO:0007416)2.93194364
116mechanosensory behavior (GO:0007638)2.92481368
117mating behavior (GO:0007617)2.91761360
118synaptic transmission (GO:0007268)2.90234968
119positive regulation of synaptic transmission (GO:0050806)2.89867622

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.77399939
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15246837
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.13089689
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10306707
5GBX2_23144817_ChIP-Seq_PC3_Human3.02189606
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.86525994
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.86525994
8RARB_27405468_Chip-Seq_BRAIN_Mouse2.80326648
9DROSHA_22980978_ChIP-Seq_HELA_Human2.76043117
10REST_21632747_ChIP-Seq_MESCs_Mouse2.75430369
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68051093
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.63737342
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.59429828
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58641674
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.51971961
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51755624
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.44169742
18* EZH2_27294783_Chip-Seq_ESCs_Mouse2.35733636
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.33520595
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.28979104
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.27048871
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.26410504
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.23383545
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22987843
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.18320010
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.03856266
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94533882
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92489329
29AR_21572438_ChIP-Seq_LNCaP_Human1.84689846
30CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81118875
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.74633032
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.58253978
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.49846974
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48608273
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45450051
36SMAD4_21799915_ChIP-Seq_A2780_Human1.43260826
37DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37947812
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37203705
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37014385
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34768596
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.33853619
42KDM2B_26808549_Chip-Seq_K562_Human1.33281480
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32936718
44ZNF274_21170338_ChIP-Seq_K562_Hela1.27312100
45TAF15_26573619_Chip-Seq_HEK293_Human1.26233353
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.25891774
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25825185
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25661991
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24992138
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24241672
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.24222332
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.24060223
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21033110
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20959986
55AR_19668381_ChIP-Seq_PC3_Human1.19829236
56RING1B_27294783_Chip-Seq_NPCs_Mouse1.19303404
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18738779
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18265081
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.18079369
60STAT3_23295773_ChIP-Seq_U87_Human1.14263042
61SMAD3_21741376_ChIP-Seq_EPCs_Human1.13818917
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11334826
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11074780
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08022294
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07270700
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05769276
67AR_25329375_ChIP-Seq_VCAP_Human1.05732344
68P300_19829295_ChIP-Seq_ESCs_Human1.05156463
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.04624750
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.04413647
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.04012071
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03784947
73SMAD_19615063_ChIP-ChIP_OVARY_Human1.03474163
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01763953
75TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00977275
76ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00846915
77TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98989324
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98714139
79* TCF4_23295773_ChIP-Seq_U87_Human0.98482219
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98201773
81YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97667031
82CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97613858
83ARNT_22903824_ChIP-Seq_MCF-7_Human0.96580908
84TET1_21490601_ChIP-Seq_MESCs_Mouse0.95749273
85KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95731016
86AHR_22903824_ChIP-Seq_MCF-7_Human0.95124280
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95030370
88TP53_16413492_ChIP-PET_HCT116_Human0.94028735
89SMAD3_21741376_ChIP-Seq_ESCs_Human0.93649744
90DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93336411
91ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93214998
92SMAD4_21741376_ChIP-Seq_HESCs_Human0.92120459
93PIAS1_25552417_ChIP-Seq_VCAP_Human0.91111446
94BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90801176
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89909504
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89909504
97CTCF_27219007_Chip-Seq_Bcells_Human0.89238208
98DPY_21335234_ChIP-Seq_ESCs_Mouse0.89068349
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.88892566
100LXR_22292898_ChIP-Seq_THP-1_Human0.87091650
101RNF2_27304074_Chip-Seq_NSC_Mouse0.86966261
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85382357
103PRDM14_20953172_ChIP-Seq_ESCs_Human0.85232125
104NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85207616
105TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.84970725
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84655447
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84614471
108OCT4_19829295_ChIP-Seq_ESCs_Human0.84010828
109AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83940756
110RUNX2_22187159_ChIP-Seq_PCA_Human0.83739196
111SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.83638800
112RXR_22108803_ChIP-Seq_LS180_Human0.83353828
113CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82897776
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81884670
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.81841716
116KLF4_19829295_ChIP-Seq_ESCs_Human0.81337571
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81229056
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80876083
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79401227
120* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.79177673
121PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77745000
122ISL1_27105846_Chip-Seq_CPCs_Mouse0.76733412
123SOX9_26525672_Chip-Seq_HEART_Mouse0.76149249
124LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75231774
125POU5F1_16518401_ChIP-PET_MESCs_Mouse0.74600968

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.78544401
2MP0003880_abnormal_central_pattern4.54810165
3MP0003635_abnormal_synaptic_transmissio4.25653969
4MP0004270_analgesia4.08356855
5MP0009745_abnormal_behavioral_response3.42578904
6MP0009046_muscle_twitch3.37418253
7MP0002063_abnormal_learning/memory/cond3.34025275
8MP0002064_seizures3.23866315
9MP0001968_abnormal_touch/_nociception3.08861943
10MP0005423_abnormal_somatic_nervous3.01567537
11MP0002822_catalepsy2.99024829
12MP0002734_abnormal_mechanical_nocicepti2.85801630
13MP0002272_abnormal_nervous_system2.79593300
14MP0002572_abnormal_emotion/affect_behav2.74818565
15MP0001486_abnormal_startle_reflex2.68708026
16MP0002736_abnormal_nociception_after2.32113665
17MP0008569_lethality_at_weaning2.27604972
18MP0002735_abnormal_chemical_nociception2.25030189
19MP0002733_abnormal_thermal_nociception2.15570981
20MP0001501_abnormal_sleep_pattern2.13917848
21MP0003329_amyloid_beta_deposits2.11993734
22MP0001970_abnormal_pain_threshold2.08698802
23MP0001440_abnormal_grooming_behavior2.08240172
24MP0002067_abnormal_sensory_capabilities2.00238302
25MP0004858_abnormal_nervous_system1.89756584
26MP0004811_abnormal_neuron_physiology1.87524557
27MP0002184_abnormal_innervation1.85632778
28MP0000778_abnormal_nervous_system1.83777491
29MP0009780_abnormal_chondrocyte_physiolo1.77091625
30MP0004885_abnormal_endolymph1.74762831
31MP0004924_abnormal_behavior1.73401132
32MP0005386_behavior/neurological_phenoty1.73401132
33MP0000955_abnormal_spinal_cord1.71682385
34MP0002557_abnormal_social/conspecific_i1.69415865
35MP0003123_paternal_imprinting1.68261624
36MP0002909_abnormal_adrenal_gland1.57778954
37MP0002066_abnormal_motor_capabilities/c1.52370396
38MP0003633_abnormal_nervous_system1.52343641
39MP0002882_abnormal_neuron_morphology1.48520832
40MP0000920_abnormal_myelination1.46855750
41MP0003879_abnormal_hair_cell1.43940881
42MP0004142_abnormal_muscle_tone1.35302050
43MP0003631_nervous_system_phenotype1.33611754
44MP0006276_abnormal_autonomic_nervous1.28815246
45MP0005646_abnormal_pituitary_gland1.23815391
46MP0001984_abnormal_olfaction1.23582778
47MP0004145_abnormal_muscle_electrophysio1.23542699
48MP0001905_abnormal_dopamine_level1.17051567
49MP0003690_abnormal_glial_cell1.16773834
50MP0002152_abnormal_brain_morphology1.16332452
51MP0001529_abnormal_vocalization1.15970317
52MP0004742_abnormal_vestibular_system1.12441882
53MP0003632_abnormal_nervous_system1.08537412
54MP0002229_neurodegeneration1.06216901
55MP0003787_abnormal_imprinting1.04991410
56MP0003634_abnormal_glial_cell1.03713104
57MP0001502_abnormal_circadian_rhythm1.03240119
58MP0003121_genomic_imprinting1.00613690
59MP0001177_atelectasis0.98912843
60MP0002638_abnormal_pupillary_reflex0.98814763
61MP0003075_altered_response_to0.98792845
62MP0008872_abnormal_physiological_respon0.98340316
63MP0000569_abnormal_digit_pigmentation0.96844898
64MP0000751_myopathy0.96191415
65MP0000604_amyloidosis0.95854661
66MP0008874_decreased_physiological_sensi0.94354534
67MP0005645_abnormal_hypothalamus_physiol0.91645978
68MP0001346_abnormal_lacrimal_gland0.89377245
69MP0003283_abnormal_digestive_organ0.89191206
70MP0002069_abnormal_eating/drinking_beha0.89132687
71MP0005623_abnormal_meninges_morphology0.85805127
72MP0000566_synostosis0.84032636
73MP0000579_abnormal_nail_morphology0.81111046
74MP0000013_abnormal_adipose_tissue0.79547471
75MP0008877_abnormal_DNA_methylation0.78901818
76MP0005551_abnormal_eye_electrophysiolog0.78644915
77MP0004085_abnormal_heartbeat0.78588705
78MP0001485_abnormal_pinna_reflex0.77220834
79MP0002752_abnormal_somatic_nervous0.77046640
80MP0001963_abnormal_hearing_physiology0.77007877
81MP0002653_abnormal_ependyma_morphology0.75745515
82MP0001188_hyperpigmentation0.74111782
83MP0001299_abnormal_eye_distance/0.73861321
84MP0005409_darkened_coat_color0.71959283
85MP0005499_abnormal_olfactory_system0.71462982
86MP0005394_taste/olfaction_phenotype0.71462982
87MP0005535_abnormal_body_temperature0.71189339
88MP0003137_abnormal_impulse_conducting0.70839444
89MP0008961_abnormal_basal_metabolism0.70682779
90MP0003938_abnormal_ear_development0.70480854
91MP0000026_abnormal_inner_ear0.68503555
92MP0002249_abnormal_larynx_morphology0.67980580
93MP0005167_abnormal_blood-brain_barrier0.65762954
94MP0002090_abnormal_vision0.65450145
95MP0004147_increased_porphyrin_level0.64818030
96MP0004043_abnormal_pH_regulation0.64773837
97MP0003122_maternal_imprinting0.64037209
98MP0006292_abnormal_olfactory_placode0.61050876
99MP0000631_abnormal_neuroendocrine_gland0.60951764
100MP0003861_abnormal_nervous_system0.60934984
101MP0004484_altered_response_of0.59831583
102MP0004510_myositis0.59280675
103MP0000747_muscle_weakness0.58919509
104MP0004233_abnormal_muscle_weight0.58439716
105MP0003172_abnormal_lysosome_physiology0.57906695
106MP0010386_abnormal_urinary_bladder0.57543635
107MP0004130_abnormal_muscle_cell0.57461117
108MP0002081_perinatal_lethality0.56893295
109MP0001348_abnormal_lacrimal_gland0.56812665
110MP0004215_abnormal_myocardial_fiber0.56075318
111MP0001943_abnormal_respiration0.55903160
112MP0010769_abnormal_survival0.55591286
113MP0001986_abnormal_taste_sensitivity0.55369412
114MP0003119_abnormal_digestive_system0.53032575
115MP0002089_abnormal_postnatal_growth/wei0.52079893
116MP0010768_mortality/aging0.51758274
117MP0010770_preweaning_lethality0.51637950
118MP0002082_postnatal_lethality0.51637950

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.38435550
2Focal motor seizures (HP:0011153)6.94238047
3Focal seizures (HP:0007359)5.56215235
4Visual hallucinations (HP:0002367)5.07707867
5Action tremor (HP:0002345)4.98695529
6Progressive cerebellar ataxia (HP:0002073)4.50445230
7Epileptic encephalopathy (HP:0200134)4.30231048
8Atonic seizures (HP:0010819)4.14022630
9Supranuclear gaze palsy (HP:0000605)4.04381575
10Ankle clonus (HP:0011448)4.03341279
11Febrile seizures (HP:0002373)3.81833723
12Gaze-evoked nystagmus (HP:0000640)3.68667222
13Absence seizures (HP:0002121)3.68410210
14Broad-based gait (HP:0002136)3.61978923
15Poor eye contact (HP:0000817)3.59537758
16Generalized tonic-clonic seizures (HP:0002069)3.56397834
17Dysdiadochokinesis (HP:0002075)3.49568195
18Dysmetria (HP:0001310)3.49511249
19Dialeptic seizures (HP:0011146)3.41661545
20Impaired vibration sensation in the lower limbs (HP:0002166)3.35462079
21Intention tremor (HP:0002080)3.29051781
22Scanning speech (HP:0002168)3.25553193
23Depression (HP:0000716)3.25529540
24Impaired social interactions (HP:0000735)3.20944033
25Abnormal social behavior (HP:0012433)3.20944033
26Neurofibrillary tangles (HP:0002185)3.17588369
27Papilledema (HP:0001085)3.16471064
28Truncal ataxia (HP:0002078)3.16435021
29Urinary bladder sphincter dysfunction (HP:0002839)3.15722208
30Mutism (HP:0002300)3.11356708
31Urinary urgency (HP:0000012)3.06978139
32Spastic gait (HP:0002064)3.05773432
33Anxiety (HP:0000739)2.99765167
34Abnormality of the corticospinal tract (HP:0002492)2.99715102
35Postural instability (HP:0002172)2.98311162
36Insidious onset (HP:0003587)2.91313448
37Termporal pattern (HP:0011008)2.91313448
38Impaired smooth pursuit (HP:0007772)2.91176969
39Cerebral inclusion bodies (HP:0100314)2.90016827
40Abnormal eating behavior (HP:0100738)2.87359290
41Cerebral hypomyelination (HP:0006808)2.86344325
42Sleep apnea (HP:0010535)2.85326767
43Abnormality of the lower motor neuron (HP:0002366)2.83040683
44Hemiparesis (HP:0001269)2.80700137
45Megalencephaly (HP:0001355)2.77263004
46Genetic anticipation (HP:0003743)2.76746669
47Torticollis (HP:0000473)2.76170701
48Hemiplegia (HP:0002301)2.74016377
49Amblyopia (HP:0000646)2.65905456
50Annular pancreas (HP:0001734)2.63971838
51Diplopia (HP:0000651)2.61518984
52Abnormality of binocular vision (HP:0011514)2.61518984
53Abnormality of ocular smooth pursuit (HP:0000617)2.57666529
54Focal dystonia (HP:0004373)2.53848545
55Stereotypic behavior (HP:0000733)2.52222566
56Dysmetric saccades (HP:0000641)2.51560343
57Akinesia (HP:0002304)2.50514561
58Polyphagia (HP:0002591)2.49457699
59Hyperventilation (HP:0002883)2.45608212
60Ventricular fibrillation (HP:0001663)2.44074128
61Lower limb muscle weakness (HP:0007340)2.38536913
62Bronchomalacia (HP:0002780)2.36437180
63Insomnia (HP:0100785)2.36308821
64Excessive salivation (HP:0003781)2.35013211
65Drooling (HP:0002307)2.35013211
66Progressive inability to walk (HP:0002505)2.32550527
67Bradykinesia (HP:0002067)2.32337028
68Turricephaly (HP:0000262)2.30010884
69Aplasia of the phalanges of the hand (HP:0009802)2.29152548
70Aplasia involving bones of the extremities (HP:0009825)2.29152548
71Aplasia involving bones of the upper limbs (HP:0009823)2.29152548
72Clonus (HP:0002169)2.28935679
73Craniofacial dystonia (HP:0012179)2.27472093
74Pointed chin (HP:0000307)2.27102114
75Impaired vibratory sensation (HP:0002495)2.26482375
76Status epilepticus (HP:0002133)2.18617920
77Amyotrophic lateral sclerosis (HP:0007354)2.17603907
78Pheochromocytoma (HP:0002666)2.17386457
79Abnormality of saccadic eye movements (HP:0000570)2.16700482
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.16159756
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16159756
82Epileptiform EEG discharges (HP:0011182)2.14604153
83Neuronal loss in central nervous system (HP:0002529)2.14283566
84Fetal akinesia sequence (HP:0001989)2.13639551
85EEG with generalized epileptiform discharges (HP:0011198)2.12505392
86Diminished motivation (HP:0000745)2.12174909
87Limb dystonia (HP:0002451)2.11799270
88Gait ataxia (HP:0002066)2.09458014
89Bundle branch block (HP:0011710)2.07620924
90Hypsarrhythmia (HP:0002521)2.07258975
91Split foot (HP:0001839)2.04831142
92Absent speech (HP:0001344)2.04355197
93Obstructive sleep apnea (HP:0002870)2.02268179
94Peripheral hypomyelination (HP:0007182)2.00833423
95Lower limb asymmetry (HP:0100559)2.00750717
96Agitation (HP:0000713)1.98766209
97Postural tremor (HP:0002174)1.97629076
98Onion bulb formation (HP:0003383)1.96726136
99Generalized myoclonic seizures (HP:0002123)1.95460090
100Overriding aorta (HP:0002623)1.94919688
101Incomplete penetrance (HP:0003829)1.92753998
102Resting tremor (HP:0002322)1.90501328
103Spastic tetraparesis (HP:0001285)1.89658887
104CNS hypomyelination (HP:0003429)1.87207344
105Tetraplegia (HP:0002445)1.86516468
106Choreoathetosis (HP:0001266)1.86120709
107Lower limb amyotrophy (HP:0007210)1.85257180
108Morphological abnormality of the pyramidal tract (HP:0002062)1.84742900
109Rigidity (HP:0002063)1.82040906
110Ankyloglossia (HP:0010296)1.81775311
111Delusions (HP:0000746)1.81765100
112Rapidly progressive (HP:0003678)1.81471222
113Apathy (HP:0000741)1.81302723
114Inappropriate behavior (HP:0000719)1.79931867
115Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.78801503
116Hammertoe (HP:0001765)1.76768702
117Shallow orbits (HP:0000586)1.74710181
118Hand muscle atrophy (HP:0009130)1.74594678
119Spastic tetraplegia (HP:0002510)1.74455520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.09852059
2NTRK34.06183815
3MAP3K93.88822835
4MARK13.20190195
5MAP3K42.73479360
6DAPK22.71595800
7MINK12.70137803
8PAK62.54959530
9PRKD32.41646164
10KSR22.33636294
11CAMKK12.17748745
12NTRK12.12433939
13MAP2K72.10597621
14NTRK22.06297414
15RIPK41.71924819
16MAP2K41.71780943
17CDK51.62873442
18CDK191.59251656
19CAMKK21.50504951
20TYRO31.45919406
21KSR11.44437102
22STK381.40617814
23UHMK11.39211501
24TNIK1.33831585
25MAP3K21.30868311
26PRPF4B1.30560042
27SIK21.28742742
28DAPK11.28420382
29GRK51.23112223
30MAPK131.19403843
31PNCK1.18688367
32MAP3K121.18513844
33PRKCG1.13190683
34OXSR11.12605214
35ARAF1.12562548
36FES1.11674080
37PHKG21.11183803
38PHKG11.11183803
39PLK21.10942690
40WNK11.09358414
41TAOK11.07091171
42SGK4941.05036559
43SGK2231.05036559
44CDK151.03781297
45STK111.03658745
46CDK181.02363776
47LATS21.01943078
48RET1.00438677
49CDK141.00287776
50MAP3K130.96501769
51ALK0.95274821
52PRKCH0.94456018
53CAMK10.94317506
54PINK10.93388355
55RIPK10.92085061
56STK390.91663177
57CDK11A0.91133241
58CASK0.90694766
59CAMK2A0.86929197
60DYRK20.85551107
61LMTK20.82699432
62MARK20.80449960
63CAMK2B0.78518642
64PDK10.75428630
65PDPK10.74723349
66PAK30.71688034
67CSNK1G20.71278431
68MAPKAPK50.70348944
69RAF10.65862822
70PTK2B0.65428854
71SGK10.64306834
72MAPK120.63789805
73DYRK1A0.62660692
74SGK30.61694891
75FGFR20.55697335
76FYN0.54982266
77NEK60.54636707
78SGK20.54189294
79DAPK30.53300020
80MAP3K10.52996546
81CAMK1G0.51736261
82PRKCZ0.51494615
83PKN10.51150484
84CAMK2G0.50750577
85ERBB20.50223637
86RPS6KA30.50161634
87SCYL20.50103088
88CDC42BPA0.49565909
89ROCK20.49260446
90BRAF0.49117552
91CAMK40.48647198
92BMPR20.48361554
93CAMK2D0.47092994
94MAPK100.45602997
95BRSK10.43790471
96PRKCE0.43294866
97TNK20.42745813
98WNK40.42724343
99LIMK10.42530592
100FGR0.39834015
101ICK0.37143558
102MAP3K70.36329133
103MAP2K10.36226711
104DDR20.35672559
105CAMK1D0.35568595
106MAP3K110.35483677
107PDGFRA0.35384618
108RPS6KA20.31492074
109ROCK10.30851194
110BCR0.30263108
111MAPK80.29702182
112CSNK1E0.29520583
113CSNK1D0.28607796
114GSK3B0.28327666
115SRC0.27067674
116PRKDC0.25137850
117PRKG10.24527758

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38371772
2Synaptic vesicle cycle_Homo sapiens_hsa047213.13393193
3Glutamatergic synapse_Homo sapiens_hsa047242.70317418
4Olfactory transduction_Homo sapiens_hsa047402.69742486
5Circadian entrainment_Homo sapiens_hsa047132.66854492
6GABAergic synapse_Homo sapiens_hsa047272.64201449
7Long-term potentiation_Homo sapiens_hsa047202.64161301
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.58347804
9Morphine addiction_Homo sapiens_hsa050322.43413884
10Amphetamine addiction_Homo sapiens_hsa050312.32104059
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.25947974
12Salivary secretion_Homo sapiens_hsa049702.16922334
13Dopaminergic synapse_Homo sapiens_hsa047282.14432699
14Gastric acid secretion_Homo sapiens_hsa049711.97813981
15Cholinergic synapse_Homo sapiens_hsa047251.96974245
16Insulin secretion_Homo sapiens_hsa049111.89249668
17Long-term depression_Homo sapiens_hsa047301.86135667
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83140565
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.76150660
20Nitrogen metabolism_Homo sapiens_hsa009101.66507206
21Oxytocin signaling pathway_Homo sapiens_hsa049211.65420512
22Taste transduction_Homo sapiens_hsa047421.61054151
23Cocaine addiction_Homo sapiens_hsa050301.59397000
24Renin secretion_Homo sapiens_hsa049241.59153777
25Serotonergic synapse_Homo sapiens_hsa047261.52780284
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49381474
27GnRH signaling pathway_Homo sapiens_hsa049121.49162978
28Calcium signaling pathway_Homo sapiens_hsa040201.47496236
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.46385840
30Gap junction_Homo sapiens_hsa045401.41133117
31Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36688641
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.27290423
33cAMP signaling pathway_Homo sapiens_hsa040241.25723115
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.22521916
35Type II diabetes mellitus_Homo sapiens_hsa049301.22008266
36Estrogen signaling pathway_Homo sapiens_hsa049151.21814930
37Vitamin B6 metabolism_Homo sapiens_hsa007501.20816799
38Glioma_Homo sapiens_hsa052141.20750756
39Axon guidance_Homo sapiens_hsa043601.17058658
40ErbB signaling pathway_Homo sapiens_hsa040121.07433678
41Melanogenesis_Homo sapiens_hsa049161.03553342
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02306526
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01766523
44Collecting duct acid secretion_Homo sapiens_hsa049661.01511283
45Phospholipase D signaling pathway_Homo sapiens_hsa040721.00371710
46Dorso-ventral axis formation_Homo sapiens_hsa043200.95149220
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.95023958
48Oocyte meiosis_Homo sapiens_hsa041140.92317910
49Cardiac muscle contraction_Homo sapiens_hsa042600.90918082
50Pancreatic secretion_Homo sapiens_hsa049720.90024646
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85669510
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83636956
53Thyroid hormone synthesis_Homo sapiens_hsa049180.80815898
54Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79884754
55Choline metabolism in cancer_Homo sapiens_hsa052310.77780251
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76353803
57VEGF signaling pathway_Homo sapiens_hsa043700.74472114
58MAPK signaling pathway_Homo sapiens_hsa040100.72373966
59Dilated cardiomyopathy_Homo sapiens_hsa054140.71293922
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71023094
61Neurotrophin signaling pathway_Homo sapiens_hsa047220.70311175
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.69008179
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68376956
64Endocytosis_Homo sapiens_hsa041440.65760448
65Vibrio cholerae infection_Homo sapiens_hsa051100.62827141
66Ras signaling pathway_Homo sapiens_hsa040140.62237247
67Rap1 signaling pathway_Homo sapiens_hsa040150.61930604
68Phototransduction_Homo sapiens_hsa047440.61355602
69Hippo signaling pathway_Homo sapiens_hsa043900.60287996
70Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.58180652
71mTOR signaling pathway_Homo sapiens_hsa041500.57297850
72Renal cell carcinoma_Homo sapiens_hsa052110.55471451
73Bile secretion_Homo sapiens_hsa049760.54935133
74Alcoholism_Homo sapiens_hsa050340.54923481
75Inositol phosphate metabolism_Homo sapiens_hsa005620.54707358
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.53982313
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53226134
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52037823
79Non-small cell lung cancer_Homo sapiens_hsa052230.51708627
80Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50010637
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49228355
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48684301
83Endometrial cancer_Homo sapiens_hsa052130.48488678
84Glucagon signaling pathway_Homo sapiens_hsa049220.46112284
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44223269
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42291693
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.42283388
88Chemokine signaling pathway_Homo sapiens_hsa040620.41005102
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40386749
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39836695
91Prion diseases_Homo sapiens_hsa050200.39643521
92Arginine and proline metabolism_Homo sapiens_hsa003300.38629748
93Wnt signaling pathway_Homo sapiens_hsa043100.38461020
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37812153
95Insulin signaling pathway_Homo sapiens_hsa049100.35525626
96AMPK signaling pathway_Homo sapiens_hsa041520.35484860
97Ovarian steroidogenesis_Homo sapiens_hsa049130.34002937
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33891662
99Tight junction_Homo sapiens_hsa045300.33880194
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32899759
101Hedgehog signaling pathway_Homo sapiens_hsa043400.32678116
102Type I diabetes mellitus_Homo sapiens_hsa049400.32310248
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32070105
104Platelet activation_Homo sapiens_hsa046110.29731527
105Glycerophospholipid metabolism_Homo sapiens_hsa005640.29626806
106Basal cell carcinoma_Homo sapiens_hsa052170.27337121
107Circadian rhythm_Homo sapiens_hsa047100.27258388
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27232030
109Colorectal cancer_Homo sapiens_hsa052100.26467813
110Arginine biosynthesis_Homo sapiens_hsa002200.25872292
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.22542348
112Fatty acid biosynthesis_Homo sapiens_hsa000610.22003857
113Alzheimers disease_Homo sapiens_hsa050100.21855514

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