FAM131C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.54753280
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.54753280
3L-phenylalanine metabolic process (GO:0006558)6.45386259
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.45386259
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.91363991
6synaptic vesicle maturation (GO:0016188)5.80800332
7glutamate secretion (GO:0014047)5.77177736
8aromatic amino acid family catabolic process (GO:0009074)5.66306129
9alpha-linolenic acid metabolic process (GO:0036109)5.60521274
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.59748625
11synaptic vesicle exocytosis (GO:0016079)5.42456406
12glyoxylate metabolic process (GO:0046487)5.26667289
13pyrimidine nucleobase catabolic process (GO:0006208)5.26201963
14kynurenine metabolic process (GO:0070189)5.24551170
15cerebellar granule cell differentiation (GO:0021707)5.17564317
16bile acid biosynthetic process (GO:0006699)5.10033846
17cellular ketone body metabolic process (GO:0046950)5.06298422
18high-density lipoprotein particle remodeling (GO:0034375)5.03546862
19sulfur amino acid catabolic process (GO:0000098)4.95140847
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.95074553
21indole-containing compound catabolic process (GO:0042436)4.90988716
22indolalkylamine catabolic process (GO:0046218)4.90988716
23tryptophan catabolic process (GO:0006569)4.90988716
24negative regulation of fibrinolysis (GO:0051918)4.88131518
25urea cycle (GO:0000050)4.82911920
26urea metabolic process (GO:0019627)4.82911920
27cysteine metabolic process (GO:0006534)4.82501664
28serine family amino acid catabolic process (GO:0009071)4.79187410
29lysine catabolic process (GO:0006554)4.76970846
30lysine metabolic process (GO:0006553)4.76970846
31cellular potassium ion homeostasis (GO:0030007)4.75247755
32regulation of short-term neuronal synaptic plasticity (GO:0048172)4.67892586
33positive regulation of synapse maturation (GO:0090129)4.66240572
34tryptophan metabolic process (GO:0006568)4.59031090
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.57818134
36regulation of fibrinolysis (GO:0051917)4.53618756
37positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.51506257
38regulation of triglyceride catabolic process (GO:0010896)4.51066060
39locomotory exploration behavior (GO:0035641)4.50588458
40amino-acid betaine metabolic process (GO:0006577)4.48442099
41neurotransmitter secretion (GO:0007269)4.45376889
42nitrogen cycle metabolic process (GO:0071941)4.44653439
43protein carboxylation (GO:0018214)4.43871618
44peptidyl-glutamic acid carboxylation (GO:0017187)4.43871618
45positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.43179101
46regulation of cholesterol esterification (GO:0010872)4.36863513
47reverse cholesterol transport (GO:0043691)4.36836920
48negative regulation of cholesterol transport (GO:0032375)4.36085706
49negative regulation of sterol transport (GO:0032372)4.36085706
50regulation of protein activation cascade (GO:2000257)4.35604610
51bile acid metabolic process (GO:0008206)4.34947081
52ketone body metabolic process (GO:1902224)4.33659398
53fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.30128146
54glutamate metabolic process (GO:0006536)4.29445701
55nucleobase catabolic process (GO:0046113)4.28035843
56dendritic spine morphogenesis (GO:0060997)4.25293777
57dicarboxylic acid biosynthetic process (GO:0043650)4.21363069
58regulation of synaptic vesicle exocytosis (GO:2000300)4.19839758
59cell migration in hindbrain (GO:0021535)4.19645737
60neuronal ion channel clustering (GO:0045161)4.19574090
61protein-lipid complex remodeling (GO:0034368)4.19224017
62macromolecular complex remodeling (GO:0034367)4.19224017
63plasma lipoprotein particle remodeling (GO:0034369)4.19224017
64complement activation, alternative pathway (GO:0006957)4.17516466
65alpha-amino acid catabolic process (GO:1901606)4.16094528
66acylglycerol homeostasis (GO:0055090)4.16016169
67triglyceride homeostasis (GO:0070328)4.16016169
68glycine metabolic process (GO:0006544)4.13534323
69aromatic amino acid family metabolic process (GO:0009072)4.12118824
70ethanol oxidation (GO:0006069)4.10693356
71auditory behavior (GO:0031223)4.08857228
72phospholipid efflux (GO:0033700)4.08094318
73coenzyme catabolic process (GO:0009109)4.06025956
74regulation of complement activation (GO:0030449)4.03217787
75negative regulation of leukocyte chemotaxis (GO:0002689)3.99214459
76cellular amino acid catabolic process (GO:0009063)3.95096738
77tyrosine metabolic process (GO:0006570)3.87392105
78serine family amino acid metabolic process (GO:0009069)3.87144123
79plasma lipoprotein particle clearance (GO:0034381)3.84785428
80acetyl-CoA metabolic process (GO:0006084)3.80397082
81cellular modified amino acid catabolic process (GO:0042219)3.79969452
82cerebellar Purkinje cell differentiation (GO:0021702)3.79723963
83aspartate family amino acid catabolic process (GO:0009068)3.76661136
84homocysteine metabolic process (GO:0050667)3.76105766
85regulation of synaptic vesicle transport (GO:1902803)3.73306670
86sodium ion export (GO:0071436)3.71990129
87regulation of vesicle fusion (GO:0031338)3.69865440
88regulation of cholesterol homeostasis (GO:2000188)3.68854581
89cellular glucuronidation (GO:0052695)3.68346590
90drug catabolic process (GO:0042737)3.68262199
91short-chain fatty acid metabolic process (GO:0046459)3.62656915
92positive regulation of neurotransmitter transport (GO:0051590)3.62211281
93cholesterol efflux (GO:0033344)3.60485003
94negative regulation of fatty acid biosynthetic process (GO:0045717)3.60137221
95positive regulation of lipid catabolic process (GO:0050996)3.60121523
96imidazole-containing compound metabolic process (GO:0052803)3.59926764
97regulation of synapse structural plasticity (GO:0051823)3.56164254
98bile acid and bile salt transport (GO:0015721)3.55519304
99postsynaptic membrane organization (GO:0001941)3.53694184
100arginine metabolic process (GO:0006525)3.53333846
101regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.52380274
102regulation of neuronal synaptic plasticity (GO:0048168)3.51607215
103negative regulation of lipase activity (GO:0060192)3.51585770
104positive regulation of lipoprotein lipase activity (GO:0051006)3.50275220
105positive regulation of triglyceride lipase activity (GO:0061365)3.50275220
106serine family amino acid biosynthetic process (GO:0009070)3.48677849
107dendritic spine organization (GO:0097061)3.47521536
108carboxylic acid catabolic process (GO:0046395)3.47396585
109organic acid catabolic process (GO:0016054)3.47396585
110positive regulation of fatty acid beta-oxidation (GO:0032000)3.46588855
111benzene-containing compound metabolic process (GO:0042537)3.44273841
1122-oxoglutarate metabolic process (GO:0006103)3.44073000
113regulation of synapse maturation (GO:0090128)3.43393334
114fatty acid beta-oxidation (GO:0006635)3.39487461
115serotonin metabolic process (GO:0042428)3.39307083
116cell differentiation in hindbrain (GO:0021533)3.39125158
117carnitine metabolic process (GO:0009437)3.39094274
118exploration behavior (GO:0035640)3.36866994
119fatty acid oxidation (GO:0019395)3.36141847
120synaptic vesicle endocytosis (GO:0048488)3.35588215
121dicarboxylic acid catabolic process (GO:0043649)3.34685315
122regulation of fatty acid beta-oxidation (GO:0031998)3.34671228
123neurotransmitter transport (GO:0006836)3.34248523
124indolalkylamine metabolic process (GO:0006586)3.33244043
125monocarboxylic acid catabolic process (GO:0072329)3.32927424
126mechanosensory behavior (GO:0007638)3.32508632
127regulation of glutamate receptor signaling pathway (GO:1900449)3.32466540
128protein localization to synapse (GO:0035418)3.32034305
129positive regulation of membrane potential (GO:0045838)3.29588513
130lipid oxidation (GO:0034440)3.29366130
131synaptic transmission, glutamatergic (GO:0035249)3.28563023
132regulation of long-term neuronal synaptic plasticity (GO:0048169)3.28366845
133potassium ion homeostasis (GO:0055075)3.27249730
134establishment of mitochondrion localization (GO:0051654)3.27028952
135regulation of cholesterol biosynthetic process (GO:0045540)3.26026323
136response to misfolded protein (GO:0051788)3.25583593
137exogenous drug catabolic process (GO:0042738)3.24595657
138regulation of cholesterol metabolic process (GO:0090181)3.24532567
139fatty acid catabolic process (GO:0009062)3.23232592
140positive regulation of triglyceride metabolic process (GO:0090208)3.23102352
141glucuronate metabolic process (GO:0019585)3.21149438
142uronic acid metabolic process (GO:0006063)3.21149438
143flavonoid metabolic process (GO:0009812)3.21033362
144heme transport (GO:0015886)3.19051250
145neuronal action potential propagation (GO:0019227)3.18786956
146low-density lipoprotein particle remodeling (GO:0034374)3.18418788
147gamma-aminobutyric acid transport (GO:0015812)3.16989443
148primary amino compound metabolic process (GO:1901160)3.16694049
149ionotropic glutamate receptor signaling pathway (GO:0035235)3.15071071
150chemosensory behavior (GO:0007635)3.14178181
151positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13629928
152regulation of voltage-gated calcium channel activity (GO:1901385)3.13422023
153glycerophospholipid catabolic process (GO:0046475)3.09653439
154regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.08155485
155substrate-independent telencephalic tangential migration (GO:0021826)3.07314428
156substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.07314428
157neuron-neuron synaptic transmission (GO:0007270)3.06182026
158vocalization behavior (GO:0071625)3.05561704
159central nervous system myelination (GO:0022010)3.04478805
160axon ensheathment in central nervous system (GO:0032291)3.04478805
161regulation of neurotransmitter levels (GO:0001505)3.04219864
162response to auditory stimulus (GO:0010996)3.03444477
163cellular sodium ion homeostasis (GO:0006883)3.01428942
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.99970796
165axonal fasciculation (GO:0007413)2.98730738
166protein polyglutamylation (GO:0018095)2.98493431
167regulation of neurotransmitter secretion (GO:0046928)2.97873622
168mitochondrion transport along microtubule (GO:0047497)2.93892203
169establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93892203
170regulation of autophagic vacuole assembly (GO:2000785)2.92023590
171positive regulation of dendritic spine development (GO:0060999)2.92008668
172presynaptic membrane organization (GO:0097090)2.91617345
173neurotransmitter-gated ion channel clustering (GO:0072578)2.89942487
174regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89911762
175regulation of calcium ion-dependent exocytosis (GO:0017158)2.89379615
176regulation of postsynaptic membrane potential (GO:0060078)2.89255537
177layer formation in cerebral cortex (GO:0021819)2.88821116
178adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88298930
179regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84311327
180regulation of neurotransmitter transport (GO:0051588)2.83141792
181transmission of nerve impulse (GO:0019226)2.79947588
182neuron cell-cell adhesion (GO:0007158)2.79301514
183regulation of synaptic plasticity (GO:0048167)2.74248256
184neurofilament cytoskeleton organization (GO:0060052)2.74164184
185regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.73474342
186negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73221306
187potassium ion import (GO:0010107)2.72128580
188neuron recognition (GO:0008038)2.72100547
189glutamate receptor signaling pathway (GO:0007215)2.71379706
190adult walking behavior (GO:0007628)2.69610285
191positive regulation of neurotransmitter secretion (GO:0001956)2.68248422
192neuromuscular process controlling balance (GO:0050885)2.67815169
193membrane depolarization during action potential (GO:0086010)2.66037337
194neuromuscular process controlling posture (GO:0050884)2.64456012
195cell communication by electrical coupling (GO:0010644)2.63252090
196calcium ion-dependent exocytosis (GO:0017156)2.61712796
197regulation of membrane repolarization (GO:0060306)2.60612617
198neuromuscular synaptic transmission (GO:0007274)2.60543063
199long-term memory (GO:0007616)2.59500591
200detection of calcium ion (GO:0005513)2.58092650

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.49207344
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.69414258
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.88343049
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.01925511
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.97902578
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.24007858
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.15750682
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.38496635
9EZH2_27304074_Chip-Seq_ESCs_Mouse3.32074695
10JARID2_20064375_ChIP-Seq_MESCs_Mouse3.29562393
11CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.25542573
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07003728
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.97925317
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.93068066
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.93068066
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.88671451
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.73812761
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64822749
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.64636369
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.63938650
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.58941478
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52272956
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.44366864
24SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40228751
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.39230822
26ZNF263_19887448_ChIP-Seq_K562_Human2.36803752
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.33331623
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.30166817
29ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.24260274
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.23019170
31TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.10433073
32BMI1_23680149_ChIP-Seq_NPCS_Mouse2.08367435
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.02428961
34GBX2_23144817_ChIP-Seq_PC3_Human1.95807119
35RING1B_27294783_Chip-Seq_ESCs_Mouse1.79690867
36ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79191275
37TP53_20018659_ChIP-ChIP_R1E_Mouse1.77973107
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.73182040
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.66472461
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57935434
41OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.57759113
42RING1B_27294783_Chip-Seq_NPCs_Mouse1.55992329
43CLOCK_20551151_ChIP-Seq_293T_Human1.54115268
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.49974999
45NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.47390617
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.45720500
47RNF2_27304074_Chip-Seq_NSC_Mouse1.43220798
48* LXR_22292898_ChIP-Seq_THP-1_Human1.43127530
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.40701711
50EZH2_22144423_ChIP-Seq_EOC_Human1.40279814
51FOXA2_19822575_ChIP-Seq_HepG2_Human1.39190490
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36112866
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.34693318
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34179062
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.31394278
56SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.29040722
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.27823143
58HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27420421
59THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27337953
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.26702898
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.16773939
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16707666
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.14120915
64ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11213560
65FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08194489
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06303310
67STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04481008
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04235170
69CREB1_26743006_Chip-Seq_LNCaP_Human1.00767863
70REST_18959480_ChIP-ChIP_MESCs_Mouse1.00545946
71RXRA_24833708_ChIP-Seq_LIVER_Mouse1.00306260
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97902984
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97850835
74* KDM2B_26808549_Chip-Seq_K562_Human0.97399265
75* CTCF_27219007_Chip-Seq_Bcells_Human0.94426923
76REST_21632747_ChIP-Seq_MESCs_Mouse0.93941721
77DROSHA_22980978_ChIP-Seq_HELA_Human0.93759697
78NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.93172084
79RACK7_27058665_Chip-Seq_MCF-7_Human0.93070779
80SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91929955
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.91337423
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91066157
83BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.90675043
84TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.89717589
85GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.89023656
86* TET1_21451524_ChIP-Seq_MESCs_Mouse0.88914988
87AR_19668381_ChIP-Seq_PC3_Human0.88364458
88* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.86559825
89SMAD4_21741376_ChIP-Seq_ESCs_Human0.86391268
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86148545
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.85487891
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85215815
93WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84284044
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.83694102
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83124654
96HTT_18923047_ChIP-ChIP_STHdh_Human0.83074340
97SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83000640
98* RARB_27405468_Chip-Seq_BRAIN_Mouse0.82517267
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.82168195
100* P68_20966046_ChIP-Seq_HELA_Human0.82141221
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81485932
102OCT4_19829295_ChIP-Seq_ESCs_Human0.80429437
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.79834711
104RARA_24833708_ChIP-Seq_LIVER_Mouse0.79474250
105RAD21_21589869_ChIP-Seq_MESCs_Mouse0.79129160
106SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.78717832
107SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78348211
108* SMC4_20622854_ChIP-Seq_HELA_Human0.78040367
109TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77038228
110POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77038228
111* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76445278
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.76350017
113SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.76161904
114AR_25329375_ChIP-Seq_VCAP_Human0.75726828
115* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.75612543
116RARB_24833708_ChIP-Seq_LIVER_Mouse0.75493531
117ZFP281_27345836_Chip-Seq_ESCs_Mouse0.74686380
118TRIM28_21343339_ChIP-Seq_HEK293_Human0.74259311
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73226835
120OCT4_18692474_ChIP-Seq_MEFs_Mouse0.73011638
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.72155232
122KDM2B_26808549_Chip-Seq_SUP-B15_Human0.70988161
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70912527
124POU5F1_16518401_ChIP-PET_MESCs_Mouse0.70677276
125DPY_21335234_ChIP-Seq_ESCs_Mouse0.70186758
126CTCF_20526341_ChIP-Seq_ESCs_Human0.69961199
127CTBP2_25329375_ChIP-Seq_LNCAP_Human0.69553380
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.69340777
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69247463
130P53_22127205_ChIP-Seq_FIBROBLAST_Human0.68742700
131JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.68712511
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.68182061
133TCF3_18692474_ChIP-Seq_MEFs_Mouse0.68092796
134SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.67917787
135KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.67176063
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.66818031
137MYC_19829295_ChIP-Seq_ESCs_Human0.66801621
138NANOG_16518401_ChIP-PET_MESCs_Mouse0.66195028
139* ATF3_27146783_Chip-Seq_COLON_Human0.65801030
140SOX3_22085726_ChIP-Seq_NPCs_Mouse0.65325805
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.64909023
142CTBP1_25329375_ChIP-Seq_LNCAP_Human0.64803894
143BCOR_27268052_Chip-Seq_Bcells_Human0.64771073
144POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.64674861
145* E2F1_20622854_ChIP-Seq_HELA_Human0.62748459
146* SA1_27219007_Chip-Seq_ERYTHROID_Human0.62530329
147KLF4_19829295_ChIP-Seq_ESCs_Human0.61504073
148SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.61482482
149SOX2_18692474_ChIP-Seq_MESCs_Mouse0.61269858
150TET1_21490601_ChIP-Seq_MESCs_Mouse0.61226963
151AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.60383408
152KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.59383835
153PHF8_20622854_ChIP-Seq_HELA_Human0.59098670
154* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.59072852
155ELF1_20517297_ChIP-Seq_JURKAT_Human0.58733549
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.57631217

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.73216120
2MP0005360_urolithiasis6.39398236
3MP0005085_abnormal_gallbladder_physiolo5.73469821
4MP0005365_abnormal_bile_salt5.57277334
5MP0008875_abnormal_xenobiotic_pharmacok4.86778812
6MP0003806_abnormal_nucleotide_metabolis4.45901505
7MP0010329_abnormal_lipoprotein_level3.50227249
8MP0003252_abnormal_bile_duct3.43949179
9MP0009840_abnormal_foam_cell3.27963963
10MP0003880_abnormal_central_pattern3.21561475
11MP0003123_paternal_imprinting3.18777180
12MP0003787_abnormal_imprinting2.91607365
13MP0009046_muscle_twitch2.83516939
14MP0004742_abnormal_vestibular_system2.77148879
15MP0003879_abnormal_hair_cell2.72181355
16MP0003122_maternal_imprinting2.63248854
17MP0002272_abnormal_nervous_system2.63152347
18MP0005083_abnormal_biliary_tract2.53440387
19MP0005332_abnormal_amino_acid2.51011860
20MP0001984_abnormal_olfaction2.40747975
21MP0003195_calcinosis2.25247868
22MP0005379_endocrine/exocrine_gland_phen2.17183622
23MP0003191_abnormal_cellular_cholesterol2.15330118
24MP0001666_abnormal_nutrient_absorption2.10415347
25MP0002572_abnormal_emotion/affect_behav2.08636892
26MP0001486_abnormal_startle_reflex2.08541146
27MP0002118_abnormal_lipid_homeostasis2.08436566
28MP0002734_abnormal_mechanical_nocicepti2.05438055
29MP0001188_hyperpigmentation2.02592948
30MP0000609_abnormal_liver_physiology1.91857303
31MP0004019_abnormal_vitamin_homeostasis1.87282483
32MP0006292_abnormal_olfactory_placode1.86114886
33MP0003329_amyloid_beta_deposits1.82537005
34MP0002557_abnormal_social/conspecific_i1.81104904
35MP0002735_abnormal_chemical_nociception1.80912885
36MP0003121_genomic_imprinting1.71511700
37MP0000778_abnormal_nervous_system1.70155897
38MP0005584_abnormal_enzyme/coenzyme_acti1.68662079
39MP0001968_abnormal_touch/_nociception1.68480524
40MP0005319_abnormal_enzyme/_coenzyme1.68289252
41MP0003868_abnormal_feces_composition1.56488100
42MP0003705_abnormal_hypodermis_morpholog1.53743872
43MP0001970_abnormal_pain_threshold1.52369870
44MP0000604_amyloidosis1.50177474
45MP0001905_abnormal_dopamine_level1.49933001
46MP0008569_lethality_at_weaning1.49841825
47MP0005646_abnormal_pituitary_gland1.44385876
48MP0002067_abnormal_sensory_capabilities1.41548519
49MP0002882_abnormal_neuron_morphology1.39621863
50MP0004130_abnormal_muscle_cell1.39272483
51MP0001501_abnormal_sleep_pattern1.38779067
52MP0000566_synostosis1.38224182
53MP0000955_abnormal_spinal_cord1.38216207
54MP0005451_abnormal_body_composition1.35252606
55MP0001485_abnormal_pinna_reflex1.31484095
56MP0005386_behavior/neurological_phenoty1.29532740
57MP0004924_abnormal_behavior1.29532740
58MP0005551_abnormal_eye_electrophysiolog1.29114215
59MP0002234_abnormal_pharynx_morphology1.26507392
60MP0010234_abnormal_vibrissa_follicle1.25487692
61MP0002066_abnormal_motor_capabilities/c1.24664347
62MP0001529_abnormal_vocalization1.21102576
63MP0001502_abnormal_circadian_rhythm1.20791238
64MP0002138_abnormal_hepatobiliary_system1.18713680
65MP0002163_abnormal_gland_morphology1.16983893
66MP0005647_abnormal_sex_gland1.16420000
67MP0003633_abnormal_nervous_system1.14662328
68MP0006072_abnormal_retinal_apoptosis1.14138256
69MP0002736_abnormal_nociception_after1.11392824
70MP0001727_abnormal_embryo_implantation1.06923064
71MP0001963_abnormal_hearing_physiology1.06647305
72MP0002229_neurodegeneration1.05062527
73MP0006036_abnormal_mitochondrial_physio1.02382017
74MP0004859_abnormal_synaptic_plasticity1.00588272
75MP0009643_abnormal_urine_homeostasis1.00457744
76MP0006035_abnormal_mitochondrial_morpho0.98815035
77MP0002152_abnormal_brain_morphology0.97247368
78MP0005266_abnormal_metabolism0.96319107
79MP0003631_nervous_system_phenotype0.95723941
80MP0001944_abnormal_pancreas_morphology0.94878391
81MP0000026_abnormal_inner_ear0.94190484
82MP0010386_abnormal_urinary_bladder0.93687969
83MP0008789_abnormal_olfactory_epithelium0.92822483
84MP0009379_abnormal_foot_pigmentation0.92165363
85MP0003137_abnormal_impulse_conducting0.92053216
86MP0002752_abnormal_somatic_nervous0.91656389
87MP0000598_abnormal_liver_morphology0.91262529
88MP0002078_abnormal_glucose_homeostasis0.91173411
89MP0003283_abnormal_digestive_organ0.89888264
90MP0002249_abnormal_larynx_morphology0.88740050
91MP0002909_abnormal_adrenal_gland0.88600748
92MP0003878_abnormal_ear_physiology0.88474526
93MP0005377_hearing/vestibular/ear_phenot0.88474526
94MP0000383_abnormal_hair_follicle0.87729647
95MP0001764_abnormal_homeostasis0.87511289
96MP0003635_abnormal_synaptic_transmissio0.86317617
97MP0000427_abnormal_hair_cycle0.86063160
98MP0002638_abnormal_pupillary_reflex0.85752752
99MP0002822_catalepsy0.85149208
100MP0003186_abnormal_redox_activity0.84453966
101MP0009053_abnormal_anal_canal0.83572060
102MP0005535_abnormal_body_temperature0.83511744
103MP0010678_abnormal_skin_adnexa0.83022152
104MP0008961_abnormal_basal_metabolism0.83004248
105MP0001348_abnormal_lacrimal_gland0.82760375
106MP0001346_abnormal_lacrimal_gland0.82760130
107MP0005623_abnormal_meninges_morphology0.82580413
108MP0010030_abnormal_orbit_morphology0.82472065
109MP0004270_analgesia0.82000204
110MP0003634_abnormal_glial_cell0.81765260
111MP0000579_abnormal_nail_morphology0.81633030
112MP0001270_distended_abdomen0.79862669
113MP0000631_abnormal_neuroendocrine_gland0.76961745
114MP0005187_abnormal_penis_morphology0.76828051
115MP0002063_abnormal_learning/memory/cond0.76420987
116MP0002837_dystrophic_cardiac_calcinosis0.76166868
117MP0000462_abnormal_digestive_system0.76027255
118MP0004510_myositis0.75852646
119MP0003656_abnormal_erythrocyte_physiolo0.73972855
120MP0001440_abnormal_grooming_behavior0.73754021
121MP0000647_abnormal_sebaceous_gland0.73472522
122MP0005448_abnormal_energy_balance0.73214048
123MP0003938_abnormal_ear_development0.73018804
124MP0009642_abnormal_blood_homeostasis0.71652404
125MP0005666_abnormal_adipose_tissue0.71468222
126MP0004858_abnormal_nervous_system0.70167766
127MP0000920_abnormal_myelination0.70041249
128MP0004185_abnormal_adipocyte_glucose0.69962031
129MP0003861_abnormal_nervous_system0.69766886
130MP0003690_abnormal_glial_cell0.69181222
131MP0004885_abnormal_endolymph0.69091190
132MP0003011_delayed_dark_adaptation0.68846374
133MP0004085_abnormal_heartbeat0.68574238
134MP0009672_abnormal_birth_weight0.67486033
135MP0002971_abnormal_brown_adipose0.66383763
136MP0002653_abnormal_ependyma_morphology0.65928258
137MP0005376_homeostasis/metabolism_phenot0.64711647
138MP0002796_impaired_skin_barrier0.63519844
139MP0009745_abnormal_behavioral_response0.63031553
140MP0005248_abnormal_Harderian_gland0.62688128
141MP0002876_abnormal_thyroid_physiology0.61329849
142MP0005334_abnormal_fat_pad0.60977873
143MP0009780_abnormal_chondrocyte_physiolo0.60581427
144MP0004043_abnormal_pH_regulation0.60425887
145MP0001756_abnormal_urination0.60159116
146MP0005423_abnormal_somatic_nervous0.60142790
147MP0003953_abnormal_hormone_level0.59305582
148MP0008872_abnormal_physiological_respon0.59276737
149MP0005636_abnormal_mineral_homeostasis0.59042746
150MP0009697_abnormal_copulation0.56942317
151MP0008874_decreased_physiological_sensi0.56760142
152MP0005499_abnormal_olfactory_system0.56541644
153MP0005394_taste/olfaction_phenotype0.56541644
154MP0002254_reproductive_system_inflammat0.55266405
155MP0002269_muscular_atrophy0.55015231
156MP0004142_abnormal_muscle_tone0.54123765
157MP0009763_increased_sensitivity_to0.53311255
158MP0001661_extended_life_span0.51695147
159MP0004133_heterotaxia0.50814060
160MP0003221_abnormal_cardiomyocyte_apopto0.49742249
161MP0000639_abnormal_adrenal_gland0.49388329
162MP0002064_seizures0.49310945
163MP0003075_altered_response_to0.48776318
164MP0002733_abnormal_thermal_nociception0.47680336
165MP0009765_abnormal_xenobiotic_induced0.47071187
166MP0002069_abnormal_eating/drinking_beha0.46901211
167MP0009764_decreased_sensitivity_to0.46564476
168MP0006276_abnormal_autonomic_nervous0.46046930
169MP0004811_abnormal_neuron_physiology0.43224012
170MP0002184_abnormal_innervation0.42969720
171MP0003718_maternal_effect0.42847501
172MP0002970_abnormal_white_adipose0.42750017
173MP0010368_abnormal_lymphatic_system0.41662758
174MP0003119_abnormal_digestive_system0.41468903
175MP0005084_abnormal_gallbladder_morpholo0.41241016

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.39252590
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.23965288
3Intrahepatic cholestasis (HP:0001406)5.84345779
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.74514519
5Hypobetalipoproteinemia (HP:0003563)5.58456833
6Xanthomatosis (HP:0000991)5.28874272
7Amblyopia (HP:0000646)5.10508710
8Hyperlipoproteinemia (HP:0010980)4.85332973
9Hyperglycinemia (HP:0002154)4.72232605
10Focal motor seizures (HP:0011153)4.66615374
11Prolonged partial thromboplastin time (HP:0003645)4.62714420
12Hyperammonemia (HP:0001987)4.40352071
13Hyperglycinuria (HP:0003108)4.28039813
14Hypolipoproteinemia (HP:0010981)4.20349748
15Ketosis (HP:0001946)4.17342058
16Abnormality of serine family amino acid metabolism (HP:0010894)4.10158163
17Abnormality of glycine metabolism (HP:0010895)4.10158163
18Complement deficiency (HP:0004431)4.08039896
19Double outlet right ventricle (HP:0001719)3.90237450
20Congenital malformation of the right heart (HP:0011723)3.90237450
21Hypoglycemic coma (HP:0001325)3.89673377
22Epidermoid cyst (HP:0200040)3.86415264
23Hypoalphalipoproteinemia (HP:0003233)3.76658008
24Limb dystonia (HP:0002451)3.75152317
25Focal seizures (HP:0007359)3.73533241
26Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.68943012
27Epileptic encephalopathy (HP:0200134)3.59790717
28Progressive cerebellar ataxia (HP:0002073)3.55890229
29Supranuclear gaze palsy (HP:0000605)3.51113869
30Delayed CNS myelination (HP:0002188)3.48307679
31Abnormality of fatty-acid metabolism (HP:0004359)3.46519520
32Visual hallucinations (HP:0002367)3.40505018
33Ketoacidosis (HP:0001993)3.39611913
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.38750296
35Febrile seizures (HP:0002373)3.36719393
36Autoamputation (HP:0001218)3.32984256
37Abnormality of sulfur amino acid metabolism (HP:0004339)3.28708990
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23023030
39Agitation (HP:0000713)3.22925672
40Abnormality of the aortic arch (HP:0012303)3.17925860
41Fat malabsorption (HP:0002630)3.11711600
42Abnormality of the common coagulation pathway (HP:0010990)3.09893346
43Joint hemorrhage (HP:0005261)3.08560780
44Abnormality of the lower motor neuron (HP:0002366)3.07226377
45Abnormality of aspartate family amino acid metabolism (HP:0010899)3.02489255
46Hypochromic microcytic anemia (HP:0004840)2.97324745
47Action tremor (HP:0002345)2.95835184
48Abnormality of the parathyroid morphology (HP:0011766)2.94416966
49Hyperthyroidism (HP:0000836)2.91912046
50Abnormality of methionine metabolism (HP:0010901)2.89762533
51Abnormality of complement system (HP:0005339)2.88247786
52Abnormal eating behavior (HP:0100738)2.87658439
53Generalized tonic-clonic seizures (HP:0002069)2.87656122
54Abnormality of pyrimidine metabolism (HP:0004353)2.87055455
55Depression (HP:0000716)2.85266890
56Hypercholesterolemia (HP:0003124)2.83049284
57Spastic diplegia (HP:0001264)2.81249349
58Anxiety (HP:0000739)2.77480217
59Intention tremor (HP:0002080)2.76790336
60Abnormality of serum amino acid levels (HP:0003112)2.75995217
61Neonatal onset (HP:0003623)2.75622313
62Hyperparathyroidism (HP:0000843)2.74587329
63Gout (HP:0001997)2.70387121
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.59371801
65Dicarboxylic aciduria (HP:0003215)2.59371801
66Cerebral hypomyelination (HP:0006808)2.58014067
67Hepatocellular carcinoma (HP:0001402)2.56949809
68Abnormality of the intrinsic pathway (HP:0010989)2.54303638
69Annular pancreas (HP:0001734)2.54297741
70Truncus arteriosus (HP:0001660)2.53021194
71Lethargy (HP:0001254)2.51459366
72Abnormal pancreas size (HP:0012094)2.50664696
73Epileptiform EEG discharges (HP:0011182)2.50285408
74Hyperbilirubinemia (HP:0002904)2.50251664
75Atonic seizures (HP:0010819)2.49535458
76Poor speech (HP:0002465)2.48058830
77Ankle clonus (HP:0011448)2.47913035
78Abnormality of nucleobase metabolism (HP:0010932)2.47669400
79Metabolic acidosis (HP:0001942)2.47146756
80Irritability (HP:0000737)2.47061812
81Neoplasm of the adrenal cortex (HP:0100641)2.45621753
82Skin nodule (HP:0200036)2.44744913
83Status epilepticus (HP:0002133)2.44560669
84Cholecystitis (HP:0001082)2.42237636
85Abnormal gallbladder physiology (HP:0012438)2.42237636
86Increased circulating renin level (HP:0000848)2.37610030
87Spastic gait (HP:0002064)2.36902008
88EEG with generalized epileptiform discharges (HP:0011198)2.32711436
89Increased hepatocellular lipid droplets (HP:0006565)2.32333648
90Polyphagia (HP:0002591)2.31425625
91Spontaneous abortion (HP:0005268)2.29258388
92Malnutrition (HP:0004395)2.29236566
93Turricephaly (HP:0000262)2.28084258
94Abnormality of purine metabolism (HP:0004352)2.27976372
95Renal Fanconi syndrome (HP:0001994)2.27646155
96Torticollis (HP:0000473)2.27603988
97Conjugated hyperbilirubinemia (HP:0002908)2.27145646
98Steatorrhea (HP:0002570)2.25713359
99Sensorimotor neuropathy (HP:0007141)2.24489377
100Back pain (HP:0003418)2.24318315
101Morphological abnormality of the pyramidal tract (HP:0002062)2.23652934
102Hemiparesis (HP:0001269)2.23121748
103Postural instability (HP:0002172)2.22318904
104Abnormality of binocular vision (HP:0011514)2.21660174
105Diplopia (HP:0000651)2.21660174
106Craniofacial dystonia (HP:0012179)2.21204959
107Genetic anticipation (HP:0003743)2.20924650
108Cholelithiasis (HP:0001081)2.20296583
109Impaired vibration sensation in the lower limbs (HP:0002166)2.19219052
110Abnormality of the Achilles tendon (HP:0005109)2.19152080
111Late onset (HP:0003584)2.18088137
112Ventricular fibrillation (HP:0001663)2.17027361
113Hypsarrhythmia (HP:0002521)2.15307766
114Hypoglycemic seizures (HP:0002173)2.13427326
115Broad-based gait (HP:0002136)2.12535212
116Increased intramyocellular lipid droplets (HP:0012240)2.12099964
117Dysmetria (HP:0001310)2.11637089
118Abnormal gallbladder morphology (HP:0012437)2.10615563
119Abnormal mitochondria in muscle tissue (HP:0008316)2.09979382
120Absence seizures (HP:0002121)2.09528527
121Urinary bladder sphincter dysfunction (HP:0002839)2.09067835
122Dysdiadochokinesis (HP:0002075)2.08435617
123Acute necrotizing encephalopathy (HP:0006965)2.07294897
124Cortical dysplasia (HP:0002539)2.05305005
125Focal dystonia (HP:0004373)2.05002673
126Degeneration of the lateral corticospinal tracts (HP:0002314)2.01992321
127Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.01992321
128Adrenal hypoplasia (HP:0000835)1.99912377
129Mitochondrial inheritance (HP:0001427)1.99378277
130Myokymia (HP:0002411)1.97482724
131Cerebral edema (HP:0002181)1.96928806
132Lipid accumulation in hepatocytes (HP:0006561)1.96877124
133Sleep apnea (HP:0010535)1.96723552
134Poor eye contact (HP:0000817)1.96348772
135Brushfield spots (HP:0001088)1.96181570
136Abnormal cartilage morphology (HP:0002763)1.95738351
137Muscular hypotonia of the trunk (HP:0008936)1.95346691
138Abnormal EKG (HP:0003115)1.95289341
139Vascular calcification (HP:0004934)1.95007973
140Cerebral inclusion bodies (HP:0100314)1.94969542
141Vomiting (HP:0002013)1.93074597
142Incomplete penetrance (HP:0003829)1.92276068
143Esotropia (HP:0000565)1.91951000
144Progressive macrocephaly (HP:0004481)1.89780739
145Psychosis (HP:0000709)1.87670647
146Decreased activity of mitochondrial respiratory chain (HP:0008972)1.87333061
147Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.87333061
148Rickets (HP:0002748)1.86853561
149Bradykinesia (HP:0002067)1.86647217
150Prolonged QT interval (HP:0001657)1.86039386
151Nuclear cataract (HP:0100018)1.85713150
152Gait imbalance (HP:0002141)1.85128836
153Neurofibrillary tangles (HP:0002185)1.84455931
154Spastic tetraparesis (HP:0001285)1.81036178
155Hyperglycemia (HP:0003074)1.80762308
156Hyperinsulinemic hypoglycemia (HP:0000825)1.80155128
157Dialeptic seizures (HP:0011146)1.79981188
158Myoglobinuria (HP:0002913)1.79923818
159Upper motor neuron abnormality (HP:0002127)1.79415026
160Tetraplegia (HP:0002445)1.78060258
161Akinesia (HP:0002304)1.77976972
162Hyperuricemia (HP:0002149)1.76369401
163Increased purine levels (HP:0004368)1.76369401
164Amyloidosis (HP:0011034)1.75570641
165Hypercalcemia (HP:0003072)1.74954939
166Generalized aminoaciduria (HP:0002909)1.74891745
167Poor suck (HP:0002033)1.74729300
168Acute encephalopathy (HP:0006846)1.74402607
169Choreoathetosis (HP:0001266)1.73695935
170Atrioventricular block (HP:0001678)1.73571158
171Abnormality of the corticospinal tract (HP:0002492)1.73540971
172Hyperventilation (HP:0002883)1.73402228
173Myocardial infarction (HP:0001658)1.73285978
174Impaired smooth pursuit (HP:0007772)1.72841149
175Hypophosphatemic rickets (HP:0004912)1.72668626
176Death in childhood (HP:0003819)1.72132484
177Metaphyseal dysplasia (HP:0100255)1.71207645
178Abnormality of proline metabolism (HP:0010907)1.71114232
179Hydroxyprolinuria (HP:0003080)1.71114232
180Growth hormone excess (HP:0000845)1.69979078
181Abnormality of the gallbladder (HP:0005264)1.69697617
182Decreased circulating renin level (HP:0003351)1.69377080
183Unilateral renal agenesis (HP:0000122)1.69258115
184Esophageal varix (HP:0002040)1.68838667
185Pseudobulbar signs (HP:0002200)1.67038515
186Reticulocytosis (HP:0001923)1.66233805

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK25.29089054
2BCKDK4.66583052
3MARK14.55654544
4BRSK13.95811313
5WEE13.55724228
6SIK13.11289281
7CASK3.04118643
8LATS22.64981455
9MAP3K92.62458595
10TRIB32.53704497
11STK162.49563712
12PKN22.46149018
13MAP2K42.43048886
14UHMK12.33722719
15NEK12.33275566
16ERN12.27415804
17SMG12.22171727
18PHKG22.20424951
19PHKG12.20424951
20DAPK22.06183059
21MINK12.00548594
22FGFR41.93704552
23VRK21.83269028
24MAP3K121.81328552
25MAP3K41.81239285
26TAF11.80118893
27ICK1.72412290
28ERBB41.69852135
29ARAF1.59334302
30GRK51.58459368
31MAP3K111.56403817
32KSR21.50262087
33PAK31.47103286
34PAK61.43865936
35PDK31.40228053
36PDK41.40228053
37NTRK21.34594025
38PNCK1.33890993
39DYRK21.27042180
40SIK21.22607561
41CAMKK21.20699038
42PBK1.17763740
43RIPK11.16148435
44LATS11.14955216
45PINK11.14308761
46TAOK11.13704006
47STK381.13433202
48PRKCZ1.13058070
49KSR11.11051602
50TYRO31.08744833
51PRKCG1.07639742
52SGK4941.05758556
53SGK2231.05758556
54PLK21.03451247
55NTRK11.03326480
56BRAF1.02228627
57CAMK2B1.02190444
58ALK1.01543337
59CSNK1G20.96709329
60MST1R0.95440854
61WNK40.92753908
62MAP3K20.92711500
63CAMKK10.89355910
64EPHA20.88657839
65ABL20.87650997
66PRKCH0.85936951
67RET0.83992119
68PTK60.83759554
69CAMK10.80842631
70PRKAA10.79563511
71AURKA0.78940026
72CAMK2G0.78869481
73CSNK1G30.77315043
74MAPK120.77083384
75MAP3K100.75847959
76MAP2K60.75704135
77CDK150.75648247
78FGFR20.73994280
79CDK11A0.73944502
80CDK60.73865546
81ERBB20.73825026
82STK38L0.73118573
83CDK180.72310850
84ERBB30.71114852
85NTRK30.70654431
86LMTK20.69482916
87DYRK1A0.67848819
88CAMK2D0.66955438
89MTOR0.66901631
90DAPK10.66532245
91MAP2K10.65966644
92CSNK1A1L0.65757940
93EPHA40.64930258
94MAPKAPK50.64424470
95HIPK20.63767082
96PDK20.63530955
97STK110.62950486
98PDPK10.61747685
99CSNK1G10.61486530
100TESK10.60977775
101CAMK2A0.60253071
102CDK50.59820068
103MAPK150.59739928
104PRKACG0.58955987
105PTK20.57863512
106PRKCI0.57402691
107TNIK0.57398613
108SCYL20.57098023
109MAP3K70.56629858
110CSNK1E0.55926295
111GSK3A0.55094898
112MAP2K70.54907165
113PRKD30.54202983
114MAPK110.53580708
115GRK60.53452954
116LIMK10.52075204
117WNK30.51343946
118AKT20.50605393
119SGK20.50251686
120DYRK1B0.47824083
121JAK20.46297114
122STK390.45491180
123EPHB20.45197512
124CAMK1G0.44727392
125SGK10.44561438
126MAP3K60.43967302
127CAMK40.42997339
128RPS6KA20.42655254
129FER0.42528767
130MAPK40.42256399
131DAPK30.42133766
132WNK10.41680584
133SGK30.41599272
134INSRR0.41325942
135IRAK20.40583111
136MAPK130.39757205
137RPS6KA30.38862392
138AKT30.38343609
139BMX0.37845637
140PDGFRA0.37774087
141MARK20.36864281
142PDK10.35637415
143CDK140.35547644
144BRD40.32824766
145PKN10.31830080
146NME10.30886898
147MAP3K10.30818632
148MAP2K20.29222095
149MAPK100.27369063
150RPS6KA10.27185008

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90340330
2Nitrogen metabolism_Homo sapiens_hsa009103.60871234
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.48553887
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.11869733
5Arginine biosynthesis_Homo sapiens_hsa002202.97397868
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.96280062
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67723603
8Fatty acid degradation_Homo sapiens_hsa000712.67675908
9Butanoate metabolism_Homo sapiens_hsa006502.62211776
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.46069165
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36982272
12Tryptophan metabolism_Homo sapiens_hsa003802.36765022
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22218387
14Glutamatergic synapse_Homo sapiens_hsa047242.19858198
15Propanoate metabolism_Homo sapiens_hsa006402.18226141
16Circadian entrainment_Homo sapiens_hsa047132.09689616
17Fatty acid metabolism_Homo sapiens_hsa012122.05425892
18Morphine addiction_Homo sapiens_hsa050322.04975525
19Amphetamine addiction_Homo sapiens_hsa050312.02584679
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00578868
21Complement and coagulation cascades_Homo sapiens_hsa046102.00404344
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.98701402
23Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.98655415
24Oxidative phosphorylation_Homo sapiens_hsa001901.97851162
25Cocaine addiction_Homo sapiens_hsa050301.96493079
26Cardiac muscle contraction_Homo sapiens_hsa042601.94874744
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92876729
28PPAR signaling pathway_Homo sapiens_hsa033201.83500839
29Long-term potentiation_Homo sapiens_hsa047201.82033127
30Bile secretion_Homo sapiens_hsa049761.81083549
31Peroxisome_Homo sapiens_hsa041461.75982257
32beta-Alanine metabolism_Homo sapiens_hsa004101.74020119
33Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.68515677
34Collecting duct acid secretion_Homo sapiens_hsa049661.67033516
35Pyruvate metabolism_Homo sapiens_hsa006201.63879707
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.60007185
37Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57371235
38Chemical carcinogenesis_Homo sapiens_hsa052041.56468091
39Parkinsons disease_Homo sapiens_hsa050121.53285588
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51972965
41Alzheimers disease_Homo sapiens_hsa050101.51406914
42Gastric acid secretion_Homo sapiens_hsa049711.51261865
43Histidine metabolism_Homo sapiens_hsa003401.48954251
44Regulation of autophagy_Homo sapiens_hsa041401.48735199
45Carbon metabolism_Homo sapiens_hsa012001.47294843
46Steroid hormone biosynthesis_Homo sapiens_hsa001401.45379754
47Phototransduction_Homo sapiens_hsa047441.43011329
48Biosynthesis of amino acids_Homo sapiens_hsa012301.41484242
49Cholinergic synapse_Homo sapiens_hsa047251.39355836
50Cyanoamino acid metabolism_Homo sapiens_hsa004601.35374357
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33949715
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33049335
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32795981
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.32640325
55Retinol metabolism_Homo sapiens_hsa008301.29656616
56Phenylalanine metabolism_Homo sapiens_hsa003601.28544437
57Selenocompound metabolism_Homo sapiens_hsa004501.25318701
58Tyrosine metabolism_Homo sapiens_hsa003501.23048581
59Renin secretion_Homo sapiens_hsa049241.22239018
60cAMP signaling pathway_Homo sapiens_hsa040241.17847065
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.17211242
62Sulfur metabolism_Homo sapiens_hsa009201.16233211
63Vibrio cholerae infection_Homo sapiens_hsa051101.12803257
64Fatty acid elongation_Homo sapiens_hsa000621.12423131
65Oxytocin signaling pathway_Homo sapiens_hsa049211.10300322
66Axon guidance_Homo sapiens_hsa043601.08536394
67Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.06962671
68Fat digestion and absorption_Homo sapiens_hsa049751.06168844
69Long-term depression_Homo sapiens_hsa047301.06030487
70Caffeine metabolism_Homo sapiens_hsa002321.05848541
71Starch and sucrose metabolism_Homo sapiens_hsa005001.05613537
72Serotonergic synapse_Homo sapiens_hsa047261.04077867
73Sulfur relay system_Homo sapiens_hsa041221.03608981
74Huntingtons disease_Homo sapiens_hsa050161.01177278
75Melanogenesis_Homo sapiens_hsa049160.99664997
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98953478
77Vitamin B6 metabolism_Homo sapiens_hsa007500.98135483
78Calcium signaling pathway_Homo sapiens_hsa040200.97567783
79Taste transduction_Homo sapiens_hsa047420.97319686
80Staphylococcus aureus infection_Homo sapiens_hsa051500.93181275
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89298732
82Folate biosynthesis_Homo sapiens_hsa007900.88222206
83Pancreatic secretion_Homo sapiens_hsa049720.88086571
84Arginine and proline metabolism_Homo sapiens_hsa003300.87297020
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86563435
86ABC transporters_Homo sapiens_hsa020100.84446756
87Inositol phosphate metabolism_Homo sapiens_hsa005620.83597379
88Fatty acid biosynthesis_Homo sapiens_hsa000610.82870472
89Basal cell carcinoma_Homo sapiens_hsa052170.81001962
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80880934
91Gap junction_Homo sapiens_hsa045400.80074260
92GnRH signaling pathway_Homo sapiens_hsa049120.77797090
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74882554
94Lysine degradation_Homo sapiens_hsa003100.74127995
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73136427
96Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70278068
97Glutathione metabolism_Homo sapiens_hsa004800.69398633
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.66242628
99Glycerolipid metabolism_Homo sapiens_hsa005610.65529729
100Olfactory transduction_Homo sapiens_hsa047400.65219572
101Steroid biosynthesis_Homo sapiens_hsa001000.64707071
102Glioma_Homo sapiens_hsa052140.64037168
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56396285
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.56336685
105Hedgehog signaling pathway_Homo sapiens_hsa043400.56262886
106Notch signaling pathway_Homo sapiens_hsa043300.55443902
107ErbB signaling pathway_Homo sapiens_hsa040120.52240763
108Prion diseases_Homo sapiens_hsa050200.52152013
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51482615
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.50404774
111Oocyte meiosis_Homo sapiens_hsa041140.49540963
112Alcoholism_Homo sapiens_hsa050340.49278472
113Wnt signaling pathway_Homo sapiens_hsa043100.47008123
114Hippo signaling pathway_Homo sapiens_hsa043900.46381265
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45671883
116Vitamin digestion and absorption_Homo sapiens_hsa049770.45479696
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.45474140
118Circadian rhythm_Homo sapiens_hsa047100.45368688
119Dilated cardiomyopathy_Homo sapiens_hsa054140.44344043
120Pentose phosphate pathway_Homo sapiens_hsa000300.43531674
121Glucagon signaling pathway_Homo sapiens_hsa049220.43447046
122Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43153242
123Thyroid hormone synthesis_Homo sapiens_hsa049180.40782982
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40380379
125One carbon pool by folate_Homo sapiens_hsa006700.39690720
126Rap1 signaling pathway_Homo sapiens_hsa040150.38466875
127MAPK signaling pathway_Homo sapiens_hsa040100.37085486
128VEGF signaling pathway_Homo sapiens_hsa043700.36875285
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.36849818
130Ras signaling pathway_Homo sapiens_hsa040140.35698139
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.35040123
132Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34462222
133Phospholipase D signaling pathway_Homo sapiens_hsa040720.34057175
134Insulin resistance_Homo sapiens_hsa049310.33509777
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32429664
136Metabolic pathways_Homo sapiens_hsa011000.32070901
137AMPK signaling pathway_Homo sapiens_hsa041520.28794474
138Ribosome_Homo sapiens_hsa030100.28702021
139GABAergic synapse_Homo sapiens_hsa047270.28566767
140Synaptic vesicle cycle_Homo sapiens_hsa047210.26865570
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.26180620
142Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.24528904
143Galactose metabolism_Homo sapiens_hsa000520.24368457
144Insulin signaling pathway_Homo sapiens_hsa049100.23819763
145Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22354430
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.20795197
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.18810798
148Fructose and mannose metabolism_Homo sapiens_hsa000510.18283834
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16572414
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16215955
151Longevity regulating pathway - mammal_Homo sapiens_hsa042110.14933136
152Type II diabetes mellitus_Homo sapiens_hsa049300.05593080
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.02572257
154Insulin secretion_Homo sapiens_hsa049110.02035594
155alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.00963423
156Dopaminergic synapse_Homo sapiens_hsa047280.00653603
157Nicotine addiction_Homo sapiens_hsa050330.00580593
158Estrogen signaling pathway_Homo sapiens_hsa049150.00030254
159Salivary secretion_Homo sapiens_hsa04970-0.0502584
160Bladder cancer_Homo sapiens_hsa05219-0.0390573
161mTOR signaling pathway_Homo sapiens_hsa04150-0.0346385
162Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261-0.0218817
163Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0184661

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