ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	7.88608152
2	chaperone-mediated protein complex assembly (GO:0051131)	4.60271367
3	presynaptic membrane assembly (GO:0097105)	4.40252653
4	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.31283858
5	gonadal mesoderm development (GO:0007506)	4.17172602
6	synapsis (GO:0007129)	4.05693589
7	intracellular protein transmembrane import (GO:0044743)	3.72262047
8	membrane repolarization during cardiac muscle cell action potential (GO:0086013)	3.65991989
9	presynaptic membrane organization (GO:0097090)	3.57090477
10	response to pheromone (GO:0019236)	3.45879632
11	protein complex biogenesis (GO:0070271)	3.44293878
12	pyrimidine nucleobase catabolic process (GO:0006208)	3.43294126
13	membrane repolarization during action potential (GO:0086011)	3.41280658
14	lateral sprouting from an epithelium (GO:0060601)	3.40095749
15	chaperone-mediated protein transport (GO:0072321)	3.32124830
16	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	3.29423783
17	postsynaptic membrane organization (GO:0001941)	3.28576200
18	somite development (GO:0061053)	3.27346874
19	otic vesicle formation (GO:0030916)	3.25886308
20	piRNA metabolic process (GO:0034587)	3.16217491
21	behavioral response to nicotine (GO:0035095)	3.14044744
22	male meiosis I (GO:0007141)	3.10920878
23	membrane repolarization (GO:0086009)	3.07585071
24	regulation of mitochondrial translation (GO:0070129)	3.06405403
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.04849896
26	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.04243579
27	chromosome organization involved in meiosis (GO:0070192)	3.03602927
28	NADH dehydrogenase complex assembly (GO:0010257)	3.02404089
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.02404089
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.02404089
31	protein-cofactor linkage (GO:0018065)	2.99724935
32	nonmotile primary cilium assembly (GO:0035058)	2.98154292
33	gamma-aminobutyric acid transport (GO:0015812)	2.97997865
34	male meiosis (GO:0007140)	2.97858891
35	intracellular protein transmembrane transport (GO:0065002)	2.90545317
36	neuron cell-cell adhesion (GO:0007158)	2.89261404
37	regulation of potassium ion transmembrane transporter activity (GO:1901016)	2.86759621
38	negative regulation of potassium ion transmembrane transport (GO:1901380)	2.85349675
39	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.84842727
40	Sertoli cell development (GO:0060009)	2.84587301
41	synaptic vesicle exocytosis (GO:0016079)	2.82864383
42	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.80781935
43	meiosis I (GO:0007127)	2.80327835
44	glutamate secretion (GO:0014047)	2.78925868
45	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.77256989
46	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.77256989
47	nucleobase catabolic process (GO:0046113)	2.75480754
48	ATP synthesis coupled proton transport (GO:0015986)	2.74413204
49	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.74413204
50	regulation of potassium ion transmembrane transport (GO:1901379)	2.71317433
51	sequestering of actin monomers (GO:0042989)	2.70040098
52	regulation of DNA endoreduplication (GO:0032875)	2.67501412
53	protein transmembrane transport (GO:0071806)	2.66698376
54	resolution of meiotic recombination intermediates (GO:0000712)	2.65511244
55	protein localization to mitochondrion (GO:0070585)	2.64656643
56	negative regulation of appetite (GO:0032099)	2.63976590
57	negative regulation of response to food (GO:0032096)	2.63976590
58	proteasome assembly (GO:0043248)	2.62974945
59	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59284656
60	neuron fate determination (GO:0048664)	2.59261772
61	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.58582876
62	regulation of mitotic spindle checkpoint (GO:1903504)	2.58582876
63	synaptonemal complex assembly (GO:0007130)	2.56262337
64	intraciliary transport (GO:0042073)	2.55185193
65	neurofilament cytoskeleton organization (GO:0060052)	2.54778671
66	establishment of protein localization to mitochondrion (GO:0072655)	2.54509060
67	water-soluble vitamin biosynthetic process (GO:0042364)	2.54477252
68	histone H4-K12 acetylation (GO:0043983)	2.53325810
69	cerebral cortex radially oriented cell migration (GO:0021799)	2.53198408
70	regulation of membrane repolarization (GO:0060306)	2.52970213
71	ATP hydrolysis coupled proton transport (GO:0015991)	2.51776296
72	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	2.51776296
73	retinal ganglion cell axon guidance (GO:0031290)	2.48995906
74	primary amino compound metabolic process (GO:1901160)	2.48752986
75	protein localization to synapse (GO:0035418)	2.47567349
76	regulation of response to food (GO:0032095)	2.43524260
77	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.43029493
78	protein neddylation (GO:0045116)	2.42983729
79	positive regulation of meiosis (GO:0045836)	2.41314886
80	synaptic vesicle maturation (GO:0016188)	2.40927237
81	behavioral response to cocaine (GO:0048148)	2.40603216
82	regulation of cilium movement (GO:0003352)	2.40053522
83	synaptonemal complex organization (GO:0070193)	2.39821471
84	negative regulation of astrocyte differentiation (GO:0048712)	2.39665518
85	appendage development (GO:0048736)	2.39241050
86	limb development (GO:0060173)	2.39241050
87	anterograde axon cargo transport (GO:0008089)	2.38593425
88	regulation of meiosis I (GO:0060631)	2.37329950
89	meiotic nuclear division (GO:0007126)	2.36674612
90	DNA methylation involved in gamete generation (GO:0043046)	2.35855722
91	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.35430044
92	establishment of integrated proviral latency (GO:0075713)	2.34721700
93	membrane assembly (GO:0071709)	2.34707681
94	calcium ion-dependent exocytosis (GO:0017156)	2.34229721
95	positive regulation of potassium ion transmembrane transport (GO:1901381)	2.33745732
96	pituitary gland development (GO:0021983)	2.33656795
97	serotonin metabolic process (GO:0042428)	2.33601438
98	neurotransmitter secretion (GO:0007269)	2.32044044
99	negative regulation of telomere maintenance (GO:0032205)	2.31729930
100	regulation of synapse structural plasticity (GO:0051823)	2.31542165

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	5.01060893
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.24163005
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.97946229
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.88486590
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.67590067
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.62510186
7	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.59725490
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28376042
9	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.25922263
10	* TAF15_26573619_Chip-Seq_HEK293_Human	2.17609619
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.16974028
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.08443384
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.04903099
14	* FUS_26573619_Chip-Seq_HEK293_Human	2.03460407
15	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.03267421
16	POU5F1_16153702_ChIP-ChIP_HESCs_Human	2.02796509
17	VDR_22108803_ChIP-Seq_LS180_Human	1.99689077
18	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.98421054
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.88030765
20	RNF2_27304074_Chip-Seq_NSC_Mouse	1.81128137
21	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.78778735
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.76349050
23	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.72099518
24	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.71316663
25	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.67669226
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.67287519
27	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.63911391
28	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.63013846
29	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.56021365
30	* P300_19829295_ChIP-Seq_ESCs_Human	1.55422775
31	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.54478509
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53662568
33	EWS_26573619_Chip-Seq_HEK293_Human	1.53257563
34	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.52466158
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49095059
36	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.47652640
37	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.47119704
38	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.45868601
39	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.45095107
40	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.44032444
41	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.37380256
42	MYC_18940864_ChIP-ChIP_HL60_Human	1.36157950
43	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.32754231
44	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.32237738
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.31818949
46	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.31572685
47	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.31274715
48	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.27914075
49	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.27757078
50	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.27381127
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.26953273
52	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.25520079
53	HTT_18923047_ChIP-ChIP_STHdh_Human	1.22069132
54	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.20255496
55	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.19112416
56	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.16297879
57	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.16262163
58	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.16059878
59	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.15068399
60	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.12708903
61	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.12224144
62	VDR_23849224_ChIP-Seq_CD4+_Human	1.10822957
63	TP53_22573176_ChIP-Seq_HFKS_Human	1.10428881
64	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.10181267
65	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.09352640
66	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.07977923
67	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.07928622
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.07375013
69	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.06405550
70	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.06167901
71	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.06124963
72	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04112321
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.03637030
74	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.02957909
75	ZFP281_18358816_ChIP-ChIP_MESCs_Mouse	1.02440609
76	SOX9_26525672_Chip-Seq_HEART_Mouse	1.01848949
77	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.01386802
78	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.00072138
79	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.99652577
80	JUN_21703547_ChIP-Seq_K562_Human	0.98782136
81	TTF2_22483619_ChIP-Seq_HELA_Human	0.97966274
82	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.97897615
83	AR_25329375_ChIP-Seq_VCAP_Human	0.95999616
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.95695957
85	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.94303529
86	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.93878797
87	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.93610029
88	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.93505173
89	IGF1R_20145208_ChIP-Seq_DFB_Human	0.93342218
90	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.92914634
91	ER_23166858_ChIP-Seq_MCF-7_Human	0.92651373
92	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.92614322
93	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.92019884
94	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.91163732
95	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.91163732
96	GABP_19822575_ChIP-Seq_HepG2_Human	0.89486655
97	* RUNX2_22187159_ChIP-Seq_PCA_Human	0.89079394
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.89052315
99	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.88463606
100	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.88128236

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.72935340
2	MP0003646_muscle_fatigue	4.86138135
3	MP0003136_yellow_coat_color	3.24014189
4	MP0008877_abnormal_DNA_methylation	3.16023412
5	MP0002653_abnormal_ependyma_morphology	2.93043328
6	MP0003880_abnormal_central_pattern	2.71430612
7	MP0006292_abnormal_olfactory_placode	2.33897261
8	MP0003121_genomic_imprinting	2.12739446
9	MP0000537_abnormal_urethra_morphology	2.09311715
10	MP0003122_maternal_imprinting	2.00467761
11	MP0004859_abnormal_synaptic_plasticity	1.98202725
12	MP0000778_abnormal_nervous_system	1.96669573
13	MP0004185_abnormal_adipocyte_glucose	1.94831084
14	MP0001485_abnormal_pinna_reflex	1.88700912
15	MP0008789_abnormal_olfactory_epithelium	1.83702431
16	MP0003635_abnormal_synaptic_transmissio	1.72916317
17	MP0004147_increased_porphyrin_level	1.72487969
18	MP0005394_taste/olfaction_phenotype	1.62654073
19	MP0005499_abnormal_olfactory_system	1.62654073
20	MP0001529_abnormal_vocalization	1.62273492
21	MP0009745_abnormal_behavioral_response	1.61839495
22	MP0003787_abnormal_imprinting	1.61267760
23	MP0008058_abnormal_DNA_repair	1.60801633
24	MP0002064_seizures	1.56961341
25	MP0004142_abnormal_muscle_tone	1.54908312
26	MP0005646_abnormal_pituitary_gland	1.54390137
27	MP0009046_muscle_twitch	1.54200214
28	MP0003123_paternal_imprinting	1.53809775
29	MP0002272_abnormal_nervous_system	1.53355309
30	MP0002063_abnormal_learning/memory/cond	1.51254436
31	MP0001188_hyperpigmentation	1.46041425
32	MP0002102_abnormal_ear_morphology	1.42801261
33	MP0006276_abnormal_autonomic_nervous	1.37020094
34	MP0002572_abnormal_emotion/affect_behav	1.36509582
35	MP0004270_analgesia	1.35449889
36	MP0009250_abnormal_appendicular_skeleto	1.35355925
37	MP0008775_abnormal_heart_ventricle	1.34506508
38	MP0001486_abnormal_startle_reflex	1.32321597
39	MP0005423_abnormal_somatic_nervous	1.31321593
40	MP0001984_abnormal_olfaction	1.29403934
41	MP0000631_abnormal_neuroendocrine_gland	1.27423084
42	MP0003938_abnormal_ear_development	1.22859976
43	MP0000955_abnormal_spinal_cord	1.18360679
44	MP0000647_abnormal_sebaceous_gland	1.18198198
45	MP0002160_abnormal_reproductive_system	1.17017624
46	MP0002938_white_spotting	1.16114993
47	MP0002067_abnormal_sensory_capabilities	1.15959303
48	MP0000049_abnormal_middle_ear	1.15564583
49	MP0002734_abnormal_mechanical_nocicepti	1.15010185
50	MP0003937_abnormal_limbs/digits/tail_de	1.13049396
51	MP0002210_abnormal_sex_determination	1.09720080
52	MP0010030_abnormal_orbit_morphology	1.09241736
53	MP0004133_heterotaxia	1.07939423
54	MP0002557_abnormal_social/conspecific_i	1.07610364
55	MP0000372_irregular_coat_pigmentation	1.05089088
56	MP0002736_abnormal_nociception_after	1.04659315
57	MP0001502_abnormal_circadian_rhythm	1.03982084
58	MP0001968_abnormal_touch/_nociception	1.01340404
59	MP0001299_abnormal_eye_distance/	1.01079169
60	MP0001293_anophthalmia	1.00466765
61	MP0005410_abnormal_fertilization	0.99772065
62	MP0000026_abnormal_inner_ear	0.99050806
63	MP0001929_abnormal_gametogenesis	0.97756847
64	MP0000569_abnormal_digit_pigmentation	0.95809723
65	MP0002184_abnormal_innervation	0.94418450
66	MP0004811_abnormal_neuron_physiology	0.93042387
67	MP0002882_abnormal_neuron_morphology	0.91531407
68	MP0003633_abnormal_nervous_system	0.89924356
69	MP0006035_abnormal_mitochondrial_morpho	0.88519784
70	MP0001853_heart_inflammation	0.87989514
71	MP0002282_abnormal_trachea_morphology	0.87565645
72	MP0003698_abnormal_male_reproductive	0.87330215
73	MP0001905_abnormal_dopamine_level	0.85801357
74	MP0002152_abnormal_brain_morphology	0.84622760
75	MP0005187_abnormal_penis_morphology	0.84516741
76	MP0001963_abnormal_hearing_physiology	0.83584186
77	MP0000653_abnormal_sex_gland	0.83318663
78	MP0001145_abnormal_male_reproductive	0.83238976
79	MP0003890_abnormal_embryonic-extraembry	0.82862680
80	MP0009053_abnormal_anal_canal	0.82670027
81	MP0005551_abnormal_eye_electrophysiolog	0.81542452
82	MP0002752_abnormal_somatic_nervous	0.81487301
83	MP0003119_abnormal_digestive_system	0.79965028
84	MP0001970_abnormal_pain_threshold	0.78562664
85	MP0001440_abnormal_grooming_behavior	0.77535799
86	MP0006072_abnormal_retinal_apoptosis	0.77150711
87	MP0005389_reproductive_system_phenotype	0.76986236
88	MP0002066_abnormal_motor_capabilities/c	0.76344816
89	MP0002733_abnormal_thermal_nociception	0.75648190
90	MP0005084_abnormal_gallbladder_morpholo	0.74648007
91	MP0003329_amyloid_beta_deposits	0.74503965
92	MP0002229_neurodegeneration	0.74342254
93	MP0003631_nervous_system_phenotype	0.74197635
94	MP0005386_behavior/neurological_phenoty	0.73294646
95	MP0004924_abnormal_behavior	0.73294646
96	MP0003878_abnormal_ear_physiology	0.72577515
97	MP0005377_hearing/vestibular/ear_phenot	0.72577515
98	MP0008569_lethality_at_weaning	0.72326825
99	MP0002822_catalepsy	0.70730438
100	MP0003861_abnormal_nervous_system	0.69159776

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Septo-optic dysplasia (HP:0100842)	3.86374487
2	Myokymia (HP:0002411)	3.75325651
3	Abnormality of the corticospinal tract (HP:0002492)	3.23131641
4	True hermaphroditism (HP:0010459)	3.21308795
5	Oligodactyly (hands) (HP:0001180)	3.18967093
6	Gait imbalance (HP:0002141)	3.13126641
7	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.08284911
8	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.08284911
9	Medial flaring of the eyebrow (HP:0010747)	2.91263183
10	Humeroradial synostosis (HP:0003041)	2.84509060
11	Synostosis involving the elbow (HP:0003938)	2.84509060
12	Optic nerve hypoplasia (HP:0000609)	2.78742845
13	Congenital primary aphakia (HP:0007707)	2.74133527
14	Abnormality of midbrain morphology (HP:0002418)	2.73468444
15	Molar tooth sign on MRI (HP:0002419)	2.73468444
16	Nephrogenic diabetes insipidus (HP:0009806)	2.64457462
17	Methylmalonic acidemia (HP:0002912)	2.60622052
18	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.54764856
19	Oligodactyly (HP:0012165)	2.54551990
20	Maternal diabetes (HP:0009800)	2.52874719
21	Atonic seizures (HP:0010819)	2.52707552
22	Acute necrotizing encephalopathy (HP:0006965)	2.51767487
23	Nephronophthisis (HP:0000090)	2.51638278
24	Absent septum pellucidum (HP:0001331)	2.50354513
25	Polyphagia (HP:0002591)	2.49360827
26	Focal motor seizures (HP:0011153)	2.46520786
27	Retinal dysplasia (HP:0007973)	2.46415307
28	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.45061600
29	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.44830241
30	Short 1st metacarpal (HP:0010034)	2.44830241
31	Increased hepatocellular lipid droplets (HP:0006565)	2.43485106
32	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.41893380
33	Microglossia (HP:0000171)	2.40954987
34	Volvulus (HP:0002580)	2.40286768
35	Amyotrophic lateral sclerosis (HP:0007354)	2.37356858
36	Abnormality of the labia minora (HP:0012880)	2.34158397
37	Abnormality of the middle phalanges of the toes (HP:0010183)	2.33863299
38	Pancreatic fibrosis (HP:0100732)	2.33591188
39	Sclerocornea (HP:0000647)	2.32735189
40	Focal seizures (HP:0007359)	2.31608280
41	Short phalanx of the thumb (HP:0009660)	2.29879974
42	Aplasia/Hypoplasia of the hallux (HP:0008362)	2.26067458
43	Specific learning disability (HP:0001328)	2.24488551
44	Mitochondrial inheritance (HP:0001427)	2.22428586
45	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.22218673
46	Fibular aplasia (HP:0002990)	2.21257383
47	Genital tract atresia (HP:0001827)	2.17516064
48	Methylmalonic aciduria (HP:0012120)	2.16440876
49	Progressive macrocephaly (HP:0004481)	2.15918091
50	Abnormal mitochondria in muscle tissue (HP:0008316)	2.15022595
51	Abnormality of the nasal septum (HP:0000419)	2.12896803
52	Lipid accumulation in hepatocytes (HP:0006561)	2.12025568
53	Hyperglycinemia (HP:0002154)	2.10460587
54	Abnormality of the 1st metacarpal (HP:0010009)	2.09226071
55	Vaginal atresia (HP:0000148)	2.08663910
56	Supernumerary spleens (HP:0009799)	2.08391418
57	Increased CSF lactate (HP:0002490)	2.06772924
58	Short hallux (HP:0010109)	2.04829602
59	Aplasia/Hypoplasia of the fibula (HP:0006492)	2.04726124
60	Pancreatic cysts (HP:0001737)	2.02829824
61	Anencephaly (HP:0002323)	2.02689323
62	Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)	1.98974424
63	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.98786632
64	Abnormality of the septum pellucidum (HP:0007375)	1.98701858
65	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.95577838
66	Hepatocellular necrosis (HP:0001404)	1.93366611
67	Anophthalmia (HP:0000528)	1.92169041
68	2-3 toe syndactyly (HP:0004691)	1.89918531
69	Acute encephalopathy (HP:0006846)	1.88984614
70	Absent phalangeal crease (HP:0006109)	1.88832311
71	Colon cancer (HP:0003003)	1.87255016
72	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.84290247
73	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.84175343
74	Abnormality of alanine metabolism (HP:0010916)	1.84175343
75	Hyperalaninemia (HP:0003348)	1.84175343
76	Poor coordination (HP:0002370)	1.82799126
77	Epileptic encephalopathy (HP:0200134)	1.82557901
78	Generalized tonic-clonic seizures (HP:0002069)	1.81236257
79	Dialeptic seizures (HP:0011146)	1.79736750
80	Febrile seizures (HP:0002373)	1.77518584
81	Abnormal eating behavior (HP:0100738)	1.77161244
82	Abnormality of the renal medulla (HP:0100957)	1.77106407
83	Morphological abnormality of the pyramidal tract (HP:0002062)	1.75056312
84	Split foot (HP:0001839)	1.74510347
85	Adrenal hypoplasia (HP:0000835)	1.72525291
86	Synostosis of carpal bones (HP:0005048)	1.72129433
87	Shoulder girdle muscle weakness (HP:0003547)	1.71666003
88	Renal Fanconi syndrome (HP:0001994)	1.71224708
89	Abnormal finger flexion creases (HP:0006143)	1.70204570
90	Progressive cerebellar ataxia (HP:0002073)	1.69683090
91	Male pseudohermaphroditism (HP:0000037)	1.68612324
92	Drooling (HP:0002307)	1.67926165
93	Postaxial foot polydactyly (HP:0001830)	1.66755699
94	Impaired vibration sensation in the lower limbs (HP:0002166)	1.65968255
95	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.65074296
96	Abnormality of renal resorption (HP:0011038)	1.64627772
97	Hemiparesis (HP:0001269)	1.64590577
98	Short tibia (HP:0005736)	1.64159516
99	Chronic hepatic failure (HP:0100626)	1.63301978
100	Median cleft lip (HP:0000161)	1.62868236

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK1	3.25040160
2	PNCK	3.18530704
3	STK16	2.97594532
4	MAP2K7	2.68385660
5	EPHA4	2.64476720
6	CASK	2.60116658
7	MAP3K9	2.46492474
8	TSSK6	2.24377988
9	MAP3K4	2.01056743
10	CDK19	1.89267650
11	NTRK2	1.86427130
12	OXSR1	1.85636608
13	PHKG1	1.84658514
14	PHKG2	1.84658514
15	WNK4	1.74152219
16	DYRK2	1.73109584
17	STK39	1.71689246
18	TNIK	1.69816526
19	VRK2	1.69113597
20	PINK1	1.63029350
21	CSNK1G2	1.53589011
22	RIPK4	1.52878360
23	STK38L	1.47421278
24	WNK3	1.47280358
25	VRK1	1.45520877
26	MAP3K12	1.39179142
27	ERBB3	1.38280272
28	MAPK13	1.36892318
29	PLK2	1.36269653
30	MINK1	1.33480847
31	CSNK1G3	1.30648223
32	WEE1	1.27431616
33	BUB1	1.26957113
34	GRK7	1.26889137
35	BCKDK	1.24883650
36	CDC7	1.23365204
37	CSNK1A1L	1.22796242
38	CAMKK2	1.12189575
39	PLK3	1.10239213
40	MAPK15	1.09704781
41	BCR	1.07429235
42	CSNK1G1	1.06915093
43	NME1	1.06096445
44	PRKCG	1.03027516
45	LIMK1	1.02911495
46	TESK1	1.02270025
47	DAPK2	0.98877404
48	NTRK3	0.96327729
49	ARAF	0.94366298
50	MAP2K4	0.86096284
51	BMPR1B	0.82369977
52	TLK1	0.81897275
53	TRIM28	0.81760379
54	CDK14	0.78011054
55	NEK1	0.77129784
56	CAMK1G	0.77015750
57	CCNB1	0.76609188
58	UHMK1	0.74273775
59	PLK1	0.74214311
60	BRSK1	0.72848069
61	DMPK	0.72367773
62	CDK5	0.72096072
63	DYRK1A	0.69683141
64	SGK1	0.69675697
65	DYRK3	0.68917954
66	FRK	0.67409896
67	PRKCE	0.64218940
68	DAPK1	0.64208319
69	CAMK2A	0.64101194
70	PAK6	0.63999881
71	AURKA	0.63980439
72	LMTK2	0.61180957
73	CDK3	0.60419563
74	PAK3	0.57268308
75	CDK18	0.57121163
76	CDK15	0.56531720
77	PDK2	0.55699658
78	SIK2	0.54582661
79	CDK11A	0.54089027
80	STK38	0.49947632
81	PKN1	0.49673664
82	CAMK2B	0.48958563
83	CAMK1	0.48724203
84	ERBB4	0.48158025
85	ATR	0.47978139
86	PRKCI	0.47354988
87	ADRBK1	0.45944607
88	CAMKK1	0.44421848
89	CAMK2G	0.43999479
90	CSNK1E	0.43294857
91	PLK4	0.42657572
92	MST1R	0.40852859
93	PRKACA	0.39485537
94	CAMK1D	0.38212083
95	STK24	0.38174876
96	INSRR	0.38133199
97	MAPKAPK5	0.37986630
98	CSNK1A1	0.37080847
99	PRKCZ	0.36253546
100	TTK	0.35818411

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.43400147
2	Nicotine addiction_Homo sapiens_hsa05033	3.10942677
3	Parkinsons disease_Homo sapiens_hsa05012	2.74782476
4	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.63006401
5	Proteasome_Homo sapiens_hsa03050	2.58958932
6	Cardiac muscle contraction_Homo sapiens_hsa04260	2.22926742
7	Huntingtons disease_Homo sapiens_hsa05016	2.19256391
8	Collecting duct acid secretion_Homo sapiens_hsa04966	2.18784955
9	Alzheimers disease_Homo sapiens_hsa05010	2.15225356
10	Homologous recombination_Homo sapiens_hsa03440	1.92368450
11	Ribosome_Homo sapiens_hsa03010	1.92293956
12	Mismatch repair_Homo sapiens_hsa03430	1.86149920
13	RNA polymerase_Homo sapiens_hsa03020	1.79915113
14	GABAergic synapse_Homo sapiens_hsa04727	1.75132007
15	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.64082311
16	Basal transcription factors_Homo sapiens_hsa03022	1.63367797
17	Taste transduction_Homo sapiens_hsa04742	1.58415822
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.45995392
19	Nucleotide excision repair_Homo sapiens_hsa03420	1.44706203
20	Protein export_Homo sapiens_hsa03060	1.39493642
21	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.38237424
22	Insulin secretion_Homo sapiens_hsa04911	1.35010316
23	Fatty acid elongation_Homo sapiens_hsa00062	1.32909368
24	Amphetamine addiction_Homo sapiens_hsa05031	1.28745149
25	Circadian entrainment_Homo sapiens_hsa04713	1.28511371
26	Morphine addiction_Homo sapiens_hsa05032	1.27224940
27	Phototransduction_Homo sapiens_hsa04744	1.25392663
28	Type II diabetes mellitus_Homo sapiens_hsa04930	1.24298969
29	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.22969541
30	DNA replication_Homo sapiens_hsa03030	1.22555531
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.20125988
32	Glutamatergic synapse_Homo sapiens_hsa04724	1.19744215
33	Dopaminergic synapse_Homo sapiens_hsa04728	1.17311503
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.16626673
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15139104
36	Spliceosome_Homo sapiens_hsa03040	1.12644846
37	Butanoate metabolism_Homo sapiens_hsa00650	1.08048353
38	Salivary secretion_Homo sapiens_hsa04970	1.07135719
39	Propanoate metabolism_Homo sapiens_hsa00640	1.07010756
40	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.06739336
41	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06328533
42	Basal cell carcinoma_Homo sapiens_hsa05217	1.06112606
43	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.04647546
44	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.04226774
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.03763722
46	RNA degradation_Homo sapiens_hsa03018	1.02913701
47	Cocaine addiction_Homo sapiens_hsa05030	1.01721316
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.01551487
49	Steroid biosynthesis_Homo sapiens_hsa00100	0.99623056
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98344721
51	Oocyte meiosis_Homo sapiens_hsa04114	0.97214162
52	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.97133334
53	Folate biosynthesis_Homo sapiens_hsa00790	0.96711222
54	Vibrio cholerae infection_Homo sapiens_hsa05110	0.94855735
55	RNA transport_Homo sapiens_hsa03013	0.94803975
56	Selenocompound metabolism_Homo sapiens_hsa00450	0.89611447
57	Hippo signaling pathway_Homo sapiens_hsa04390	0.85589573
58	Base excision repair_Homo sapiens_hsa03410	0.81842644
59	Serotonergic synapse_Homo sapiens_hsa04726	0.81727745
60	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.78502292
61	Peroxisome_Homo sapiens_hsa04146	0.77445974
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76416178
63	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75471572
64	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.74998703
65	Olfactory transduction_Homo sapiens_hsa04740	0.74243048
66	Purine metabolism_Homo sapiens_hsa00230	0.72258187
67	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.72244570
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71908010
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71833478
70	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.68839787
71	Renin secretion_Homo sapiens_hsa04924	0.68029534
72	Wnt signaling pathway_Homo sapiens_hsa04310	0.64779472
73	Calcium signaling pathway_Homo sapiens_hsa04020	0.61892654
74	Regulation of autophagy_Homo sapiens_hsa04140	0.61157598
75	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.60785379
76	Cell cycle_Homo sapiens_hsa04110	0.59272307
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.58051748
78	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.57642690
79	Cholinergic synapse_Homo sapiens_hsa04725	0.56739830
80	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.56066649
81	Metabolic pathways_Homo sapiens_hsa01100	0.54495831
82	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.51749193
83	Axon guidance_Homo sapiens_hsa04360	0.51454857
84	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.51274329
85	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.51206040
86	Non-homologous end-joining_Homo sapiens_hsa03450	0.50826514
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.50277560
88	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.48400869
89	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.46231135
90	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.44732750
91	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.43686547
92	Nitrogen metabolism_Homo sapiens_hsa00910	0.43652868
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.43226232
94	Gastric acid secretion_Homo sapiens_hsa04971	0.43098131
95	Circadian rhythm_Homo sapiens_hsa04710	0.42342814
96	Carbon metabolism_Homo sapiens_hsa01200	0.41917133
97	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41777483
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.37980788
99	Melanogenesis_Homo sapiens_hsa04916	0.37827516
100	AMPK signaling pathway_Homo sapiens_hsa04152	0.36296328

FAM133A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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