FAM133B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.99729000
2establishment of protein localization to mitochondrial membrane (GO:0090151)4.51983488
3ATP synthesis coupled proton transport (GO:0015986)4.50279239
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.50279239
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06287212
6translational termination (GO:0006415)3.83250424
7maturation of SSU-rRNA (GO:0030490)3.75185768
8respiratory electron transport chain (GO:0022904)3.63510648
9protein complex biogenesis (GO:0070271)3.62844002
10axon ensheathment in central nervous system (GO:0032291)3.61314677
11central nervous system myelination (GO:0022010)3.61314677
12electron transport chain (GO:0022900)3.58977275
13mitochondrial respiratory chain complex assembly (GO:0033108)3.47204898
14mitochondrial respiratory chain complex I assembly (GO:0032981)3.42730508
15NADH dehydrogenase complex assembly (GO:0010257)3.42730508
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42730508
17limb bud formation (GO:0060174)3.41963201
18lymphoid progenitor cell differentiation (GO:0002320)3.40480040
19cotranslational protein targeting to membrane (GO:0006613)3.39417796
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36888570
21protein targeting to ER (GO:0045047)3.32316842
22DNA double-strand break processing (GO:0000729)3.28491761
23DNA ligation (GO:0006266)3.24283421
24behavioral response to nicotine (GO:0035095)3.20941191
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.18993834
26regulation of mitotic spindle checkpoint (GO:1903504)3.18972484
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.18972484
28replication fork processing (GO:0031297)3.13932414
29ribosomal large subunit biogenesis (GO:0042273)3.13210855
30centriole assembly (GO:0098534)3.11223336
31translational elongation (GO:0006414)3.10658968
32centriole replication (GO:0007099)3.10495995
33protein localization to endoplasmic reticulum (GO:0070972)3.05967082
34developmental pigmentation (GO:0048066)3.00932797
35respiratory chain complex IV assembly (GO:0008535)2.99594458
36proteasome assembly (GO:0043248)2.97482075
37DNA replication checkpoint (GO:0000076)2.96137909
38translational initiation (GO:0006413)2.95901118
39ribosomal small subunit biogenesis (GO:0042274)2.94151825
40pseudouridine synthesis (GO:0001522)2.86913536
41long-chain fatty acid biosynthetic process (GO:0042759)2.86683767
42cellular protein complex disassembly (GO:0043624)2.85707309
43nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.84284643
44regulation of pigment cell differentiation (GO:0050932)2.81083038
45CENP-A containing nucleosome assembly (GO:0034080)2.80907285
46recombinational repair (GO:0000725)2.80678251
47protein K6-linked ubiquitination (GO:0085020)2.78851207
48rRNA modification (GO:0000154)2.78592469
49cytochrome complex assembly (GO:0017004)2.77610312
50double-strand break repair via homologous recombination (GO:0000724)2.76397048
51histone H3-K4 trimethylation (GO:0080182)2.75800246
52viral life cycle (GO:0019058)2.75778031
53translation (GO:0006412)2.74613448
54kinetochore organization (GO:0051383)2.73584755
55RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.70285270
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.70285270
57negative regulation of DNA-dependent DNA replication (GO:2000104)2.68537085
58regulation of mitochondrial translation (GO:0070129)2.68150587
59organelle disassembly (GO:1903008)2.62809799
60negative regulation of transcription regulatory region DNA binding (GO:2000678)2.62168984
61spliceosomal snRNP assembly (GO:0000387)2.60254248
62water-soluble vitamin biosynthetic process (GO:0042364)2.59283585
63positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.58327463
64nuclear-transcribed mRNA catabolic process (GO:0000956)2.56314358
65regulation of helicase activity (GO:0051095)2.55724468
66chromatin remodeling at centromere (GO:0031055)2.55565424
67protein-cofactor linkage (GO:0018065)2.54857882
68protein localization to kinetochore (GO:0034501)2.54505805
69rRNA processing (GO:0006364)2.53949692
70V(D)J recombination (GO:0033151)2.53246162
71nonmotile primary cilium assembly (GO:0035058)2.53131787
72presynaptic membrane assembly (GO:0097105)2.52238972
73cellular component biogenesis (GO:0044085)2.51099260
74maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.51056064
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50876829
76rRNA metabolic process (GO:0016072)2.49407769
77detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.47725488
78transcription elongation from RNA polymerase I promoter (GO:0006362)2.47541394
79RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.47357771
80resolution of meiotic recombination intermediates (GO:0000712)2.47247928
81kinetochore assembly (GO:0051382)2.45981885
82mRNA catabolic process (GO:0006402)2.45407793
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.43584890
84transcription elongation from RNA polymerase III promoter (GO:0006385)2.43364811
85termination of RNA polymerase III transcription (GO:0006386)2.43364811
86ATP biosynthetic process (GO:0006754)2.43181544
87protein complex disassembly (GO:0043241)2.43119937
88inner mitochondrial membrane organization (GO:0007007)2.42431368
89negative regulation of mitotic sister chromatid separation (GO:2000816)2.41215235
90negative regulation of sister chromatid segregation (GO:0033046)2.41215235
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.41215235
92negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.41215235
93negative regulation of mitotic sister chromatid segregation (GO:0033048)2.41215235
94mitotic metaphase plate congression (GO:0007080)2.40713480
95hydrogen ion transmembrane transport (GO:1902600)2.40594083
96mesenchymal cell differentiation involved in kidney development (GO:0072161)2.36067742
97mesenchymal cell differentiation involved in renal system development (GO:2001012)2.36067742
98termination of RNA polymerase I transcription (GO:0006363)2.33219405
99RNA capping (GO:0036260)2.32812038
1007-methylguanosine RNA capping (GO:0009452)2.32812038
101cerebral cortex radially oriented cell migration (GO:0021799)2.30725801
102microtubule depolymerization (GO:0007019)2.29541328
103preassembly of GPI anchor in ER membrane (GO:0016254)2.28731054
104presynaptic membrane organization (GO:0097090)2.27683503
105histone H2B ubiquitination (GO:0033523)2.27361681
106negative regulation of T cell mediated immunity (GO:0002710)2.25421811
107mannosylation (GO:0097502)2.24071458
108regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.21673421
109positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.21673421
110spliceosomal complex assembly (GO:0000245)2.21400757
111positive regulation of protein homodimerization activity (GO:0090073)2.21350039
112mast cell activation (GO:0045576)2.20013747
113positive regulation of interleukin-17 production (GO:0032740)2.19594239
114regulation of histone H3-K27 methylation (GO:0061085)2.19362745
115chaperone-mediated protein transport (GO:0072321)2.18913592
116histone exchange (GO:0043486)2.18501772
117establishment of integrated proviral latency (GO:0075713)2.18401740
118regulation of DNA endoreduplication (GO:0032875)2.18381391
119ribosomal small subunit assembly (GO:0000028)2.18076737
120nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.17203431
121left/right axis specification (GO:0070986)2.16578910
122GPI anchor biosynthetic process (GO:0006506)2.16097242
123viral mRNA export from host cell nucleus (GO:0046784)2.14687963
124DNA topological change (GO:0006265)2.14076545
125regulation of double-strand break repair via homologous recombination (GO:0010569)2.13908612
126meiotic chromosome segregation (GO:0045132)2.12843082
127exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.12231597
128protein neddylation (GO:0045116)2.09484543
129negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.09064014
130negative regulation of translation, ncRNA-mediated (GO:0040033)2.09064014
131regulation of translation, ncRNA-mediated (GO:0045974)2.09064014
132microtubule polymerization or depolymerization (GO:0031109)2.08975002
133regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.08654281
134DNA replication-independent nucleosome assembly (GO:0006336)2.08462453
135DNA replication-independent nucleosome organization (GO:0034724)2.08462453
136otic vesicle formation (GO:0030916)2.07203192
137DNA damage response, detection of DNA damage (GO:0042769)2.06898201
138poly(A)+ mRNA export from nucleus (GO:0016973)2.06747547
139natural killer cell activation involved in immune response (GO:0002323)2.06732664
140negative regulation of DNA-templated transcription, elongation (GO:0032785)2.06074103
141negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.06074103
1427-methylguanosine mRNA capping (GO:0006370)2.05967045
143lateral sprouting from an epithelium (GO:0060601)2.05836954
144energy homeostasis (GO:0097009)2.05647631
145positive regulation of histone H3-K4 methylation (GO:0051571)2.05563700
146RNA-dependent DNA replication (GO:0006278)2.04532817
147positive regulation of granulocyte differentiation (GO:0030854)2.04355147
148superoxide anion generation (GO:0042554)2.04198371
149regulation of timing of cell differentiation (GO:0048505)2.03763115
150telomere maintenance via recombination (GO:0000722)2.02596016
151viral transcription (GO:0019083)2.02477101
152neutrophil activation involved in immune response (GO:0002283)2.01975509
153dentate gyrus development (GO:0021542)2.01784481
154cellular response to gamma radiation (GO:0071480)2.01299465
155positive regulation of interleukin-1 beta secretion (GO:0050718)2.01083898
156positive regulation of megakaryocyte differentiation (GO:0045654)2.00940880
157cell proliferation in forebrain (GO:0021846)2.00516999
158GTP biosynthetic process (GO:0006183)2.00257833
159positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)1.99841299
160histone mRNA metabolic process (GO:0008334)1.98210414
161regulation of nuclear cell cycle DNA replication (GO:0033262)1.98030221
162mismatch repair (GO:0006298)1.97268485
163kidney morphogenesis (GO:0060993)1.95755815
164GPI anchor metabolic process (GO:0006505)1.95346644
165definitive hemopoiesis (GO:0060216)1.94822371
166transcription from RNA polymerase I promoter (GO:0006360)1.94621040
167modulation by virus of host process (GO:0019054)1.94487471
168regulation of development, heterochronic (GO:0040034)1.93258807
169mitotic recombination (GO:0006312)1.92465507
170DNA integration (GO:0015074)1.92013571
171response to muramyl dipeptide (GO:0032495)1.91964991
172negative regulation of execution phase of apoptosis (GO:1900118)1.91526910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human3.64619010
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.29361773
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.17919499
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.00441848
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75727527
6GBX2_23144817_ChIP-Seq_PC3_Human2.67404799
7ZNF274_21170338_ChIP-Seq_K562_Hela2.63413142
8TAF15_26573619_Chip-Seq_HEK293_Human2.42230862
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36208600
10FUS_26573619_Chip-Seq_HEK293_Human2.31409881
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.29498692
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29422069
13IGF1R_20145208_ChIP-Seq_DFB_Human2.19884489
14EWS_26573619_Chip-Seq_HEK293_Human2.16751643
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.14075257
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06064359
17FLI1_27457419_Chip-Seq_LIVER_Mouse2.05794169
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03561840
19* ETS1_20019798_ChIP-Seq_JURKAT_Human2.02729862
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.01252828
21MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.94845921
22E2F4_17652178_ChIP-ChIP_JURKAT_Human1.90887066
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.90193711
24CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.89620925
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89385856
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84505093
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82552635
28VDR_22108803_ChIP-Seq_LS180_Human1.77895051
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77518500
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.75378437
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.74595943
32BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74276199
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.66613516
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.65815186
35* ER_23166858_ChIP-Seq_MCF-7_Human1.64539127
36ELK1_19687146_ChIP-ChIP_HELA_Human1.64392096
37* P300_19829295_ChIP-Seq_ESCs_Human1.61929272
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.61032565
39RNF2_27304074_Chip-Seq_NSC_Mouse1.60984299
40TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.60199430
41PADI4_21655091_ChIP-ChIP_MCF-7_Human1.60162388
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.56084722
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.55674248
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.53904354
45* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.50504890
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.47360278
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.46575976
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46462880
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.45881125
50E2F1_18555785_Chip-Seq_ESCs_Mouse1.45510714
51EZH2_22144423_ChIP-Seq_EOC_Human1.45233283
52PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44891846
53P53_22387025_ChIP-Seq_ESCs_Mouse1.44112740
54ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39399792
55CMYC_18555785_Chip-Seq_ESCs_Mouse1.39092601
56P300_18555785_Chip-Seq_ESCs_Mouse1.38572862
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38178534
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37252726
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37153990
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.36540628
61* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34787417
62IRF1_19129219_ChIP-ChIP_H3396_Human1.34493966
63EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33659513
64TTF2_22483619_ChIP-Seq_HELA_Human1.33319644
65STAT3_18555785_Chip-Seq_ESCs_Mouse1.33096063
66GABP_17652178_ChIP-ChIP_JURKAT_Human1.30922928
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.30366785
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30187033
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29607650
70NMYC_18555785_Chip-Seq_ESCs_Mouse1.29348800
71IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28723720
72SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.27932693
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25198637
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.24383362
75GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23920091
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.23539207
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.23264618
78AR_21572438_ChIP-Seq_LNCaP_Human1.23109232
79OCT4_18555785_Chip-Seq_ESCs_Mouse1.22042973
80HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.20794938
81SALL1_21062744_ChIP-ChIP_HESCs_Human1.20584077
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.20380421
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20195542
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.16984257
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16672450
86PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16463184
87SOX2_18555785_Chip-Seq_ESCs_Mouse1.16405192
88EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16160661
89CBP_20019798_ChIP-Seq_JUKART_Human1.16063527
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16063527
91TP53_22573176_ChIP-Seq_HFKS_Human1.16012408
92MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15600005
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.15498316
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15494909
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.15494909
96SMAD3_21741376_ChIP-Seq_EPCs_Human1.14745671
97MYC_18940864_ChIP-ChIP_HL60_Human1.14248206
98NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14195626
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.12454914
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.10966633
101SMAD_19615063_ChIP-ChIP_OVARY_Human1.10583601
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08613447
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07754361
104KLF4_18555785_Chip-Seq_ESCs_Mouse1.07748562
105YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07165659
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07078246
107TAL1_26923725_Chip-Seq_HPCs_Mouse1.05767997
108PIAS1_25552417_ChIP-Seq_VCAP_Human1.05667718
109NANOG_16153702_ChIP-ChIP_HESCs_Human1.04773406
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.03812690
111* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03775242
112CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03104936
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03101249
114MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02581440
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01986793
116PU1_27457419_Chip-Seq_LIVER_Mouse1.01983786
117NANOG_19829295_ChIP-Seq_ESCs_Human1.00999588
118SOX2_19829295_ChIP-Seq_ESCs_Human1.00999588
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00837550
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00227921
121SMAD1_18555785_Chip-Seq_ESCs_Mouse0.99645386
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99237869
123DCP1A_22483619_ChIP-Seq_HELA_Human0.98972676
124EED_16625203_ChIP-ChIP_MESCs_Mouse0.98795333
125* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.98674224
126JUN_21703547_ChIP-Seq_K562_Human0.97823087
127CTCF_18555785_Chip-Seq_ESCs_Mouse0.97804235
128MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97554646
129SMAD4_21799915_ChIP-Seq_A2780_Human0.97170993
130SOX2_16153702_ChIP-ChIP_HESCs_Human0.97034837
131FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96662638
132* VDR_23849224_ChIP-Seq_CD4+_Human0.95551583
133ESRRB_18555785_Chip-Seq_ESCs_Mouse0.95270063
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94671048
135LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94559182
136FOXP3_21729870_ChIP-Seq_TREG_Human0.94541007
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94023532
138RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93468520
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.93180967
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92271266
141* TCF4_22108803_ChIP-Seq_LS180_Human0.90513315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication3.08930377
2MP0001188_hyperpigmentation2.95429138
3MP0005409_darkened_coat_color2.91621807
4MP0006292_abnormal_olfactory_placode2.85242256
5MP0003136_yellow_coat_color2.84375417
6MP0003890_abnormal_embryonic-extraembry2.67337766
7MP0009379_abnormal_foot_pigmentation2.39550244
8MP0003880_abnormal_central_pattern2.35671658
9MP0005174_abnormal_tail_pigmentation2.23714092
10MP0003787_abnormal_imprinting2.22444404
11MP0000015_abnormal_ear_pigmentation2.20220370
12MP0003718_maternal_effect2.13985523
13MP0004381_abnormal_hair_follicle2.08549751
14MP0001293_anophthalmia2.03957741
15MP0004742_abnormal_vestibular_system1.99791449
16MP0002102_abnormal_ear_morphology1.99305943
17MP0005171_absent_coat_pigmentation1.97347471
18MP0000566_synostosis1.90464564
19MP0008877_abnormal_DNA_methylation1.74356420
20MP0010094_abnormal_chromosome_stability1.71319258
21MP0008058_abnormal_DNA_repair1.68702407
22MP0002009_preneoplasia1.67161761
23MP0008789_abnormal_olfactory_epithelium1.64908935
24MP0004957_abnormal_blastocyst_morpholog1.64575740
25MP0000569_abnormal_digit_pigmentation1.63148335
26MP0003122_maternal_imprinting1.60365169
27MP0002163_abnormal_gland_morphology1.60212632
28MP0001905_abnormal_dopamine_level1.47418972
29MP0008007_abnormal_cellular_replicative1.45985716
30MP0003950_abnormal_plasma_membrane1.43825543
31MP0005646_abnormal_pituitary_gland1.42952030
32MP0002095_abnormal_skin_pigmentation1.39832658
33MP0001968_abnormal_touch/_nociception1.38014413
34MP0003567_abnormal_fetal_cardiomyocyte1.37840111
35MP0005379_endocrine/exocrine_gland_phen1.34906253
36MP0005671_abnormal_response_to1.34417283
37MP0008995_early_reproductive_senescence1.34031252
38MP0002938_white_spotting1.31259761
39MP0003763_abnormal_thymus_physiology1.28969383
40MP0002148_abnormal_hypersensitivity_rea1.28804313
41MP0005187_abnormal_penis_morphology1.28671892
42MP0005499_abnormal_olfactory_system1.28378471
43MP0005394_taste/olfaction_phenotype1.28378471
44MP0002396_abnormal_hematopoietic_system1.24861543
45MP0003938_abnormal_ear_development1.24349967
46MP0001835_abnormal_antigen_presentation1.23993910
47MP0004885_abnormal_endolymph1.23965009
48MP0009697_abnormal_copulation1.23571666
49MP0000778_abnormal_nervous_system1.23089119
50MP0000920_abnormal_myelination1.21133255
51MP0005084_abnormal_gallbladder_morpholo1.20520819
52MP0002160_abnormal_reproductive_system1.17885968
53MP0003121_genomic_imprinting1.17531886
54MP0001529_abnormal_vocalization1.16691619
55MP0002751_abnormal_autonomic_nervous1.16496004
56MP0002234_abnormal_pharynx_morphology1.16472936
57MP0002210_abnormal_sex_determination1.16451644
58MP0004147_increased_porphyrin_level1.14691910
59MP0003195_calcinosis1.13092346
60MP0000383_abnormal_hair_follicle1.12946675
61MP0003693_abnormal_embryo_hatching1.12425476
62MP0002837_dystrophic_cardiac_calcinosis1.10226448
63MP0001486_abnormal_startle_reflex1.09366748
64MP0002638_abnormal_pupillary_reflex1.09300941
65MP0001984_abnormal_olfaction1.09228908
66MP0003077_abnormal_cell_cycle1.08443386
67MP0003111_abnormal_nucleus_morphology1.08189590
68MP0005075_abnormal_melanosome_morpholog1.06686022
69MP0003315_abnormal_perineum_morphology1.05227004
70MP0003123_paternal_imprinting1.05030296
71MP0003786_premature_aging1.04836620
72MP0005423_abnormal_somatic_nervous1.04480884
73MP0003119_abnormal_digestive_system1.02711931
74MP0002653_abnormal_ependyma_morphology1.02048917
75MP0004142_abnormal_muscle_tone1.01715096
76MP0005000_abnormal_immune_tolerance1.01232651
77MP0005389_reproductive_system_phenotype1.00641506
78MP0002233_abnormal_nose_morphology1.00506330
79MP0008932_abnormal_embryonic_tissue1.00125160
80MP0008872_abnormal_physiological_respon0.99122322
81MP0000631_abnormal_neuroendocrine_gland0.97276712
82MP0001929_abnormal_gametogenesis0.97114736
83MP0000026_abnormal_inner_ear0.96502221
84MP0008260_abnormal_autophagy0.95576081
85MP0000049_abnormal_middle_ear0.95130263
86MP0002277_abnormal_respiratory_mucosa0.95128664
87MP0000653_abnormal_sex_gland0.94998963
88MP0000647_abnormal_sebaceous_gland0.94810586
89MP0001986_abnormal_taste_sensitivity0.93403347
90MP0005195_abnormal_posterior_eye0.92763213
91MP0002557_abnormal_social/conspecific_i0.92173110
92MP0006035_abnormal_mitochondrial_morpho0.92138350
93MP0009250_abnormal_appendicular_skeleto0.91553964
94MP0002452_abnormal_antigen_presenting0.91493953
95MP0002419_abnormal_innate_immunity0.89087768
96MP0001145_abnormal_male_reproductive0.88682551
97MP0005387_immune_system_phenotype0.88274257
98MP0001790_abnormal_immune_system0.88274257
99MP0005391_vision/eye_phenotype0.87791989
100MP0002420_abnormal_adaptive_immunity0.87757892
101MP0001800_abnormal_humoral_immune0.87445549
102MP0001819_abnormal_immune_cell0.86526588
103MP0002723_abnormal_immune_serum0.86300789
104MP0003937_abnormal_limbs/digits/tail_de0.86106208
105MP0002272_abnormal_nervous_system0.86016425
106MP0006276_abnormal_autonomic_nervous0.85192268
107MP0003646_muscle_fatigue0.85124620
108MP0003186_abnormal_redox_activity0.83351764
109MP0003724_increased_susceptibility_to0.82854998
110MP0006072_abnormal_retinal_apoptosis0.82365272
111MP0001485_abnormal_pinna_reflex0.82270427
112MP0003698_abnormal_male_reproductive0.81674115
113MP0002177_abnormal_outer_ear0.81583876
114MP0001324_abnormal_eye_pigmentation0.80206299
115MP0000372_irregular_coat_pigmentation0.80197741
116MP0009745_abnormal_behavioral_response0.79976177
117MP0002398_abnormal_bone_marrow0.79929035
118MP0006036_abnormal_mitochondrial_physio0.79715608
119MP0000427_abnormal_hair_cycle0.79629596
120MP0009046_muscle_twitch0.79001223
121MP0004145_abnormal_muscle_electrophysio0.78881736
122MP0003861_abnormal_nervous_system0.78661171
123MP0001286_abnormal_eye_development0.78568761
124MP0003183_abnormal_peptide_metabolism0.78497199
125MP0002184_abnormal_innervation0.78273041
126MP0002928_abnormal_bile_duct0.77987302
127MP0000490_abnormal_crypts_of0.77789582
128MP0009785_altered_susceptibility_to0.77050060
129MP0004134_abnormal_chest_morphology0.77049000
130MP0003755_abnormal_palate_morphology0.76713213
131MP0001963_abnormal_hearing_physiology0.75961613
132MP0005025_abnormal_response_to0.75209970
133MP0001346_abnormal_lacrimal_gland0.75026662
134MP0001919_abnormal_reproductive_system0.74860868
135MP0009333_abnormal_splenocyte_physiolog0.72324048
136MP0004133_heterotaxia0.71407691
137MP0002752_abnormal_somatic_nervous0.71285945
138MP0000703_abnormal_thymus_morphology0.70722715
139MP0002067_abnormal_sensory_capabilities0.70653699
140MP0002736_abnormal_nociception_after0.70159598
141MP0005253_abnormal_eye_physiology0.69843227
142MP0005551_abnormal_eye_electrophysiolog0.69529855
143MP0000716_abnormal_immune_system0.68329417
144MP0001851_eye_inflammation0.67165283
145MP0001186_pigmentation_phenotype0.66630717

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)3.86454256
2Chromsome breakage (HP:0040012)3.80179520
3Abnormality of the labia minora (HP:0012880)3.45550217
4Duplicated collecting system (HP:0000081)3.35265987
5Colon cancer (HP:0003003)3.35107687
6Acute encephalopathy (HP:0006846)3.28833110
7Abnormal mitochondria in muscle tissue (HP:0008316)3.20258744
8Reticulocytopenia (HP:0001896)3.12100484
9Abnormality of the renal collecting system (HP:0004742)3.02122105
10Increased CSF lactate (HP:0002490)3.01413091
11Lipid accumulation in hepatocytes (HP:0006561)2.93578408
12Parakeratosis (HP:0001036)2.88910341
13Patchy hypopigmentation of hair (HP:0011365)2.66131106
14Macrocytic anemia (HP:0001972)2.53765800
15White forelock (HP:0002211)2.51963975
163-Methylglutaconic aciduria (HP:0003535)2.48722149
17Dynein arm defect of respiratory motile cilia (HP:0012255)2.47869600
18Absent/shortened dynein arms (HP:0200106)2.47869600
19Abnormality of the columella (HP:0009929)2.46220408
20Ectopic kidney (HP:0000086)2.43719814
21Abnormal ciliary motility (HP:0012262)2.42802172
22Absent septum pellucidum (HP:0001331)2.39876241
23Oligodactyly (hands) (HP:0001180)2.37687044
24Cerebral edema (HP:0002181)2.36844056
25Congenital, generalized hypertrichosis (HP:0004540)2.34266941
26Hepatocellular necrosis (HP:0001404)2.34192908
27Abnormality of the septum pellucidum (HP:0007375)2.33834927
28Recurrent abscess formation (HP:0002722)2.33681171
29Septo-optic dysplasia (HP:0100842)2.33626368
30Birth length less than 3rd percentile (HP:0003561)2.31193850
31Cupped ear (HP:0000378)2.30369025
32Abnormal hair whorl (HP:0010721)2.30352029
33Prostate neoplasm (HP:0100787)2.25282375
34Stomatitis (HP:0010280)2.25051539
35Duplication of thumb phalanx (HP:0009942)2.25030757
36Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.23193283
37Abnormality of the renal cortex (HP:0011035)2.22859318
38Renal cortical cysts (HP:0000803)2.17969094
39Abnormality of chromosome stability (HP:0003220)2.14092209
40Abnormal respiratory epithelium morphology (HP:0012253)2.13917395
41Abnormal respiratory motile cilium morphology (HP:0005938)2.13917395
42Gait imbalance (HP:0002141)2.13095912
43True hermaphroditism (HP:0010459)2.11546115
44Congenital primary aphakia (HP:0007707)2.10380415
45Nephronophthisis (HP:0000090)2.10278256
46Metaphyseal dysplasia (HP:0100255)2.09381438
47Hepatic necrosis (HP:0002605)2.09154950
48Abnormality of DNA repair (HP:0003254)2.08683240
49Volvulus (HP:0002580)2.07842731
50Sclerocornea (HP:0000647)2.07044846
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.06354330
52Aplasia cutis congenita (HP:0001057)2.03498857
53Abnormality of the preputium (HP:0100587)2.02797622
54Anophthalmia (HP:0000528)2.02748445
55Methylmalonic acidemia (HP:0002912)2.02147132
56Chin dimple (HP:0010751)2.01890777
57Optic neuritis (HP:0100653)2.01808723
58Retrobulbar optic neuritis (HP:0100654)2.01808723
59Genital tract atresia (HP:0001827)2.01194428
60Leukodystrophy (HP:0002415)2.00499702
61Abnormality of incisor morphology (HP:0011063)2.00096255
62Rib fusion (HP:0000902)1.99442872
63Pancreatic fibrosis (HP:0100732)1.99347216
64Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99268690
65Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99213167
66Congenital stationary night blindness (HP:0007642)1.99145913
67Pendular nystagmus (HP:0012043)1.98186316
68Abnormal respiratory motile cilium physiology (HP:0012261)1.97590033
69Asplenia (HP:0001746)1.97207382
70Nephrogenic diabetes insipidus (HP:0009806)1.96198400
71Adrenal hypoplasia (HP:0000835)1.96164539
72Intestinal atresia (HP:0011100)1.96116365
73Aplasia/Hypoplasia of the tongue (HP:0010295)1.95277454
74Acute necrotizing encephalopathy (HP:0006965)1.94547524
75Preaxial hand polydactyly (HP:0001177)1.94445309
76Absent thumb (HP:0009777)1.94258098
77Stenosis of the external auditory canal (HP:0000402)1.93475197
78Protruding tongue (HP:0010808)1.92858180
79Pallor (HP:0000980)1.92534008
80Conical tooth (HP:0000698)1.92009094
81Renal Fanconi syndrome (HP:0001994)1.91906368
82Meckel diverticulum (HP:0002245)1.91600358
83Hypoplasia of the pons (HP:0012110)1.91156121
84Exertional dyspnea (HP:0002875)1.90566961
85Abnormality of the renal medulla (HP:0100957)1.90445818
86Vaginal atresia (HP:0000148)1.89655440
87Increased hepatocellular lipid droplets (HP:0006565)1.88849186
88Medial flaring of the eyebrow (HP:0010747)1.88339562
89Hyperglycinemia (HP:0002154)1.87883700
90Molar tooth sign on MRI (HP:0002419)1.87708448
91Abnormality of midbrain morphology (HP:0002418)1.87708448
92Sloping forehead (HP:0000340)1.87158711
93Abnormality of the pons (HP:0007361)1.86633968
94Abnormal lung lobation (HP:0002101)1.86220224
95Median cleft lip (HP:0000161)1.86107049
96Increased serum lactate (HP:0002151)1.85619856
97Stomach cancer (HP:0012126)1.85545534
98Abnormality of the ileum (HP:0001549)1.84776282
99Tubulointerstitial nephritis (HP:0001970)1.84694107
100Abnormality of the axillary hair (HP:0100134)1.84582877
101Abnormality of secondary sexual hair (HP:0009888)1.84582877
102Anencephaly (HP:0002323)1.82210573
103Abnormality of the incisor (HP:0000676)1.82038937
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.81921768
105Abnormality of the nasal septum (HP:0000419)1.81582153
106Postaxial foot polydactyly (HP:0001830)1.80924522
107Abnormality of renal resorption (HP:0011038)1.80000958
108Growth hormone deficiency (HP:0000824)1.78795207
109Bifid tongue (HP:0010297)1.78767096
110Cystic liver disease (HP:0006706)1.78753672
111Recurrent bacterial skin infections (HP:0005406)1.78700918
112Obstructive lung disease (HP:0006536)1.77859874
113Chronic obstructive pulmonary disease (HP:0006510)1.77859874
114Supernumerary spleens (HP:0009799)1.77784488
115Aplasia/Hypoplasia of the earlobes (HP:0009906)1.77564989
116Patellar aplasia (HP:0006443)1.76862741
117Abolished electroretinogram (ERG) (HP:0000550)1.76479619
118Thyroiditis (HP:0100646)1.73931244
119Male pseudohermaphroditism (HP:0000037)1.73785051
120Bile duct proliferation (HP:0001408)1.73409508
121Abnormal biliary tract physiology (HP:0012439)1.73409508
122Aplasia/Hypoplasia of the spleen (HP:0010451)1.73404910
123Optic nerve hypoplasia (HP:0000609)1.73116350
124Gastrointestinal atresia (HP:0002589)1.72467953
125Fibular hypoplasia (HP:0003038)1.72459960
126Clubbing of toes (HP:0100760)1.72242315
127Hyperventilation (HP:0002883)1.71976794
128Bilateral microphthalmos (HP:0007633)1.71896833
129Medulloblastoma (HP:0002885)1.71417007
130Abnormality of the parietal bone (HP:0002696)1.70476355
131Poor coordination (HP:0002370)1.70198511
132Triphalangeal thumb (HP:0001199)1.69862358
133Small hand (HP:0200055)1.69708091
134Duodenal stenosis (HP:0100867)1.69474192
135Small intestinal stenosis (HP:0012848)1.69474192
136Nephroblastoma (Wilms tumor) (HP:0002667)1.69211999
137Severe combined immunodeficiency (HP:0004430)1.68863470
138Oligodactyly (HP:0012165)1.68214756
139Mediastinal lymphadenopathy (HP:0100721)1.68067782
140Pulmonary artery stenosis (HP:0004415)1.67964424
141Progressive macrocephaly (HP:0004481)1.66109448
142Aplasia/Hypoplasia of the patella (HP:0006498)1.66006265
143Pancreatic cysts (HP:0001737)1.65990303
144Postaxial hand polydactyly (HP:0001162)1.64987972
145Abnormality of the prostate (HP:0008775)1.64882573
146Abnormality of the duodenum (HP:0002246)1.64799581
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.64782440
148Esophageal atresia (HP:0002032)1.64686734
149Maternal diabetes (HP:0009800)1.64617624
150Mitochondrial inheritance (HP:0001427)1.64399022
151Type I transferrin isoform profile (HP:0003642)1.63831996
152Embryonal renal neoplasm (HP:0011794)1.60591778
153Optic disc pallor (HP:0000543)1.58885789
154Overfolded helix (HP:0000396)1.58596981
155Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.58251878
156Abnormal number of incisors (HP:0011064)1.57600193
157Submucous cleft hard palate (HP:0000176)1.55569196
158Nasolacrimal duct obstruction (HP:0000579)1.54914740
159Abnormal number of erythroid precursors (HP:0012131)1.54403774
160Short tibia (HP:0005736)1.53367122
161Abnormality of cells of the erythroid lineage (HP:0012130)1.52459372

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.50706439
2MKNK23.09207948
3TNIK2.82423857
4MKNK12.79580511
5BUB12.51439501
6IRAK42.44051278
7FRK2.31881767
8STK162.24353935
9WNK32.24253616
10VRK22.20252578
11SRPK12.02846801
12BRSK21.98344328
13MAP3K141.91303623
14TXK1.89001058
15PBK1.86171415
16MAP4K21.83863076
17STK391.73008286
18YES11.71521604
19PRPF4B1.68793666
20CLK11.66672181
21MAP3K41.63890755
22BMPR21.61505035
23TRIM281.60914383
24VRK11.58433765
25TAF11.56330541
26MST41.56287279
27WNK41.47664212
28NEK61.46738623
29TLK11.42374369
30TSSK61.41256348
31MAPKAPK51.40230485
32MUSK1.39095945
33BMPR1B1.37947362
34MAP2K71.35390441
35OXSR11.35223968
36IRAK31.33150534
37MAP3K121.32909487
38NEK11.31218516
39EIF2AK21.29746321
40CDK31.27545980
41ZAK1.27292161
42NLK1.25352572
43MAPK131.22656959
44ADRBK21.20634315
45NUAK11.18089513
46PDK21.15037753
47TAOK31.13375093
48CDC71.11773782
49PLK41.09805619
50PKN11.09157076
51TEC1.05379744
52RIPK41.05264352
53BCR1.03219258
54TRPM71.01698029
55GRK70.99594556
56RPS6KA50.98720092
57CSNK1G20.95802218
58IRAK20.93825528
59MAP3K60.88651830
60PRKCG0.88321782
61ATR0.88161869
62EIF2AK30.87049284
63PINK10.85492233
64PNCK0.85483821
65FGR0.82241944
66FES0.80164452
67IKBKB0.78804961
68BRD40.78633165
69IKBKE0.77529960
70NEK20.76201638
71STK30.74545516
72NTRK20.74222872
73CDK190.73474522
74GRK10.72894037
75EIF2AK10.72477991
76SIK30.72075828
77BRSK10.72009763
78CSNK1E0.71980453
79CDK80.71383953
80PIM20.71277793
81MAPK150.70722696
82CDK70.70000853
83LCK0.69219319
84PIK3CA0.68942521
85PLK20.68069616
86EPHA40.67388345
87PAK30.67165703
88IRAK10.64957644
89CSNK2A20.62644413
90PIM10.62001093
91INSRR0.61047220
92DYRK30.59096046
93LYN0.57753066
94CHUK0.57059464
95STK38L0.57050949
96KIT0.55377901
97BLK0.55062403
98CCNB10.54487878
99TIE10.53057943
100MINK10.52915275
101CHEK20.52733862
102MARK10.52548852
103CSNK1G10.52376304
104PRKCQ0.51710351
105TGFBR10.51451917
106DMPK0.50507596
107ACVR1B0.50010524
108MAP3K130.50009663
109PASK0.48539498
110ATM0.46782713
111MELK0.46442229
112ERBB30.45704112
113CSNK1G30.45527350
114CAMK2B0.45488966
115SGK4940.45054304
116SGK2230.45054304
117NME20.44371616
118AURKB0.44137223
119WEE10.43978251
120BTK0.43942967
121DYRK20.43716325
122WNK10.43541429
123PLK30.43304362
124FGFR20.43047215
125AURKA0.42761633
126CDK90.42617023
127CHEK10.42565216
128TTK0.42052497
129FGFR10.40729095
130MARK30.40642860
131CSNK1A1L0.40313477
132CDK10.40150530
133SGK20.39533118
134ADRBK10.38659859
135PRKDC0.36896727
136NTRK30.36819343
137CSNK1A10.36216253
138PRKACB0.36195389
139CSNK2A10.35611472
140CDK20.35281732
141DYRK1A0.35148485
142SYK0.35078640
143PRKCE0.34852728
144ROCK20.34829796
145NME10.34647748
146PLK10.34257705

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.47940485
2Ribosome_Homo sapiens_hsa030102.40893016
3Fanconi anemia pathway_Homo sapiens_hsa034602.33785674
4Homologous recombination_Homo sapiens_hsa034402.29832980
5Non-homologous end-joining_Homo sapiens_hsa034502.22496489
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.91771693
7Spliceosome_Homo sapiens_hsa030401.91158424
8Cardiac muscle contraction_Homo sapiens_hsa042601.85345167
9DNA replication_Homo sapiens_hsa030301.84701133
10Protein export_Homo sapiens_hsa030601.83348489
11Basal transcription factors_Homo sapiens_hsa030221.80478458
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80359522
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79981467
14Mismatch repair_Homo sapiens_hsa034301.78767290
15Graft-versus-host disease_Homo sapiens_hsa053321.67408962
16Nucleotide excision repair_Homo sapiens_hsa034201.65337907
17Oxidative phosphorylation_Homo sapiens_hsa001901.63807945
18One carbon pool by folate_Homo sapiens_hsa006701.55040153
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.51341267
20Allograft rejection_Homo sapiens_hsa053301.47267305
21RNA degradation_Homo sapiens_hsa030181.45302874
22Autoimmune thyroid disease_Homo sapiens_hsa053201.43627550
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.43274840
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.40432397
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.38024776
26Base excision repair_Homo sapiens_hsa034101.36939289
27Asthma_Homo sapiens_hsa053101.32667684
28Cell cycle_Homo sapiens_hsa041101.27487856
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.26124505
30Propanoate metabolism_Homo sapiens_hsa006401.25840285
31Ether lipid metabolism_Homo sapiens_hsa005651.23214791
32Nitrogen metabolism_Homo sapiens_hsa009101.22206960
33Parkinsons disease_Homo sapiens_hsa050121.21857196
34Sphingolipid metabolism_Homo sapiens_hsa006001.21533519
35Pyrimidine metabolism_Homo sapiens_hsa002401.17464977
36Proteasome_Homo sapiens_hsa030501.16137359
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15072533
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.14561786
39Selenocompound metabolism_Homo sapiens_hsa004501.14442168
40Huntingtons disease_Homo sapiens_hsa050161.11920912
41Phototransduction_Homo sapiens_hsa047441.09723956
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07986350
43Primary immunodeficiency_Homo sapiens_hsa053401.07189228
44Hematopoietic cell lineage_Homo sapiens_hsa046401.06728738
45Alzheimers disease_Homo sapiens_hsa050101.06695551
46Butanoate metabolism_Homo sapiens_hsa006501.06257171
47Steroid biosynthesis_Homo sapiens_hsa001001.05518620
48Nicotine addiction_Homo sapiens_hsa050331.04345494
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04013930
50Rheumatoid arthritis_Homo sapiens_hsa053231.03173201
51Measles_Homo sapiens_hsa051621.02053452
52Serotonergic synapse_Homo sapiens_hsa047260.98480534
53Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.97580016
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96153244
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.95282641
56Transcriptional misregulation in cancer_Homo sapiens_hsa052020.92960063
57mRNA surveillance pathway_Homo sapiens_hsa030150.89969440
58RNA transport_Homo sapiens_hsa030130.85669664
59Herpes simplex infection_Homo sapiens_hsa051680.85496352
60Malaria_Homo sapiens_hsa051440.84277124
61Folate biosynthesis_Homo sapiens_hsa007900.83356853
62Systemic lupus erythematosus_Homo sapiens_hsa053220.82411282
63Caffeine metabolism_Homo sapiens_hsa002320.82204516
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82138758
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81950495
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80976393
67Epstein-Barr virus infection_Homo sapiens_hsa051690.80083003
68Leishmaniasis_Homo sapiens_hsa051400.79742692
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79543749
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.79461668
71Purine metabolism_Homo sapiens_hsa002300.77753275
72Arachidonic acid metabolism_Homo sapiens_hsa005900.75297295
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75093029
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.74686827
75Type I diabetes mellitus_Homo sapiens_hsa049400.72502620
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72364114
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72342123
78Oocyte meiosis_Homo sapiens_hsa041140.71639616
79T cell receptor signaling pathway_Homo sapiens_hsa046600.71088977
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70559531
81Morphine addiction_Homo sapiens_hsa050320.70479806
82Long-term depression_Homo sapiens_hsa047300.69477402
83African trypanosomiasis_Homo sapiens_hsa051430.68578857
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68266768
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67332833
86Peroxisome_Homo sapiens_hsa041460.66422643
87Axon guidance_Homo sapiens_hsa043600.66187632
88Glutamatergic synapse_Homo sapiens_hsa047240.66161189
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.65691234
90Pertussis_Homo sapiens_hsa051330.64927256
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.63464175
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62887643
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62432016
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62084834
95Chemical carcinogenesis_Homo sapiens_hsa052040.61399735
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61164314
97p53 signaling pathway_Homo sapiens_hsa041150.61126101
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60927699
99Metabolic pathways_Homo sapiens_hsa011000.60573987
100Taste transduction_Homo sapiens_hsa047420.60180746
101Regulation of autophagy_Homo sapiens_hsa041400.60014984
102Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59359753
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59333329
104Osteoclast differentiation_Homo sapiens_hsa043800.58434100
105Hedgehog signaling pathway_Homo sapiens_hsa043400.58128779
106B cell receptor signaling pathway_Homo sapiens_hsa046620.57399325
107Alcoholism_Homo sapiens_hsa050340.56841509
108Wnt signaling pathway_Homo sapiens_hsa043100.56624644
109Pyruvate metabolism_Homo sapiens_hsa006200.56317202
110Tuberculosis_Homo sapiens_hsa051520.55638758
111TNF signaling pathway_Homo sapiens_hsa046680.54204276
112Tryptophan metabolism_Homo sapiens_hsa003800.53281911
113Chemokine signaling pathway_Homo sapiens_hsa040620.52967880
114Hepatitis B_Homo sapiens_hsa051610.52420789
115Linoleic acid metabolism_Homo sapiens_hsa005910.50973518
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49518718
117Shigellosis_Homo sapiens_hsa051310.48713853
118MicroRNAs in cancer_Homo sapiens_hsa052060.48049409
119Retinol metabolism_Homo sapiens_hsa008300.47868048
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47751197
121Steroid hormone biosynthesis_Homo sapiens_hsa001400.47388977
122Influenza A_Homo sapiens_hsa051640.46646642
123Prostate cancer_Homo sapiens_hsa052150.46472140
124Salmonella infection_Homo sapiens_hsa051320.44766671
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43835618
126Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43530155
127Ras signaling pathway_Homo sapiens_hsa040140.43440435
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43039718
129Phagosome_Homo sapiens_hsa041450.42177337
130HTLV-I infection_Homo sapiens_hsa051660.41208227
131Viral carcinogenesis_Homo sapiens_hsa052030.41053882
132GABAergic synapse_Homo sapiens_hsa047270.40511636
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.40086753
134Glutathione metabolism_Homo sapiens_hsa004800.39504483
135TGF-beta signaling pathway_Homo sapiens_hsa043500.38654280
136Melanoma_Homo sapiens_hsa052180.38227956
137MAPK signaling pathway_Homo sapiens_hsa040100.37997400
138Sulfur relay system_Homo sapiens_hsa041220.36678712
139Basal cell carcinoma_Homo sapiens_hsa052170.34750459
140Hippo signaling pathway_Homo sapiens_hsa043900.34701551
141Olfactory transduction_Homo sapiens_hsa047400.34325011
142Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33901431
143Fatty acid elongation_Homo sapiens_hsa000620.33738561
144Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32492671
145Apoptosis_Homo sapiens_hsa042100.32184657
146beta-Alanine metabolism_Homo sapiens_hsa004100.30891995
147Collecting duct acid secretion_Homo sapiens_hsa049660.30160270
148Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29960080
149Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29638841
150Vitamin digestion and absorption_Homo sapiens_hsa049770.29106197
151Dopaminergic synapse_Homo sapiens_hsa047280.25895628
152Primary bile acid biosynthesis_Homo sapiens_hsa001200.25696775
153Cocaine addiction_Homo sapiens_hsa050300.22488789
154Amphetamine addiction_Homo sapiens_hsa050310.17958985
155Circadian entrainment_Homo sapiens_hsa047130.17712611
156Circadian rhythm_Homo sapiens_hsa047100.16225023

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