ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.20113530
2	cartilage morphogenesis (GO:0060536)	6.10956103
3	kidney morphogenesis (GO:0060993)	5.07649634
4	metanephric nephron tubule development (GO:0072234)	4.58623814
5	metanephric tubule development (GO:0072170)	4.58623814
6	regulation of mesenchymal cell apoptotic process (GO:2001053)	4.27645690
7	respiratory tube development (GO:0030323)	4.20444841
8	positive regulation of action potential (GO:0045760)	4.15327072
9	metanephric nephron epithelium development (GO:0072243)	4.14953600
10	lens fiber cell development (GO:0070307)	4.11851885
11	regulation of acrosome reaction (GO:0060046)	4.05939964
12	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.96131880
13	lung epithelium development (GO:0060428)	3.93910720
14	nephron tubule development (GO:0072080)	3.91249150
15	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.89926887
16	positive regulation of meiosis (GO:0045836)	3.88277798
17	nonmotile primary cilium assembly (GO:0035058)	3.87109085
18	fusion of sperm to egg plasma membrane (GO:0007342)	3.84872527
19	axon ensheathment in central nervous system (GO:0032291)	3.81998478
20	central nervous system myelination (GO:0022010)	3.81998478
21	metanephric epithelium development (GO:0072207)	3.78854553
22	renal tubule development (GO:0061326)	3.78207186
23	auditory receptor cell differentiation (GO:0042491)	3.70727445
24	positive regulation of sodium ion transmembrane transport (GO:1902307)	3.69100393
25	cellular response to nicotine (GO:0071316)	3.58349612
26	positive regulation of meiotic cell cycle (GO:0051446)	3.57010676
27	lung-associated mesenchyme development (GO:0060484)	3.56507684
28	nephron tubule morphogenesis (GO:0072078)	3.55243594
29	nephron epithelium morphogenesis (GO:0072088)	3.55243594
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.54035805
31	behavioral response to nicotine (GO:0035095)	3.53467332
32	renal tubule morphogenesis (GO:0061333)	3.53354360
33	embryonic body morphogenesis (GO:0010172)	3.49464307
34	pattern specification involved in kidney development (GO:0061004)	3.33952974
35	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	3.33237026
36	midbrain development (GO:0030901)	3.26149970
37	nephron epithelium development (GO:0072009)	3.23661331
38	epithelial cilium movement (GO:0003351)	3.22100275
39	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.20608588
40	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	3.20435208
41	ganglion development (GO:0061548)	3.20005572
42	regulation of action potential (GO:0098900)	3.14656936
43	response to redox state (GO:0051775)	3.14236792
44	reflex (GO:0060004)	3.11632841
45	centriole replication (GO:0007099)	3.11421306
46	plasma membrane fusion (GO:0045026)	3.10752557
47	mesenchymal cell proliferation (GO:0010463)	3.04974732
48	regulation of respiratory system process (GO:0044065)	3.03378511
49	microtubule cytoskeleton organization involved in mitosis (GO:1902850)	3.00367961
50	collecting duct development (GO:0072044)	2.98000890
51	neuronal action potential (GO:0019228)	2.97071307
52	spindle assembly involved in mitosis (GO:0090307)	2.94203539
53	neuron fate determination (GO:0048664)	2.93034681
54	inner ear receptor cell differentiation (GO:0060113)	2.92677742
55	L-fucose catabolic process (GO:0042355)	2.92162859
56	fucose catabolic process (GO:0019317)	2.92162859
57	L-fucose metabolic process (GO:0042354)	2.92162859
58	body morphogenesis (GO:0010171)	2.91169278
59	dopaminergic neuron differentiation (GO:0071542)	2.90010975
60	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.88692913
61	behavioral response to ethanol (GO:0048149)	2.88324029
62	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.81867332
63	startle response (GO:0001964)	2.81324489
64	radial glial cell differentiation (GO:0060019)	2.77193522
65	protein neddylation (GO:0045116)	2.76170830
66	Sertoli cell development (GO:0060009)	2.74125782
67	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.73988718
68	protein-cofactor linkage (GO:0018065)	2.73572152
69	prenylation (GO:0097354)	2.72427331
70	protein prenylation (GO:0018342)	2.72427331
71	cilium morphogenesis (GO:0060271)	2.71356829
72	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	2.71215913
73	hematopoietic stem cell proliferation (GO:0071425)	2.69196093
74	regulation of timing of cell differentiation (GO:0048505)	2.65096192
75	preassembly of GPI anchor in ER membrane (GO:0016254)	2.64782359
76	artery development (GO:0060840)	2.62954811
77	signal peptide processing (GO:0006465)	2.62363630
78	stem cell proliferation (GO:0072089)	2.61582733
79	positive regulation of gastrulation (GO:2000543)	2.59536713
80	intraciliary transport (GO:0042073)	2.58428131
81	regulation of mesoderm development (GO:2000380)	2.51679724
82	mesenchymal-epithelial cell signaling (GO:0060638)	2.51358546
83	tongue development (GO:0043586)	2.51052052
84	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.50900113
85	anatomical structure regression (GO:0060033)	2.50267554
86	dentate gyrus development (GO:0021542)	2.48902418
87	axonemal dynein complex assembly (GO:0070286)	2.47921437
88	somite development (GO:0061053)	2.47064153
89	protein K11-linked deubiquitination (GO:0035871)	2.46712667
90	forebrain neuron differentiation (GO:0021879)	2.46548568
91	axoneme assembly (GO:0035082)	2.46437441
92	serotonin metabolic process (GO:0042428)	2.42969388
93	lung morphogenesis (GO:0060425)	2.41194008
94	limb development (GO:0060173)	2.38345013
95	appendage development (GO:0048736)	2.38345013
96	centriole assembly (GO:0098534)	2.37984630
97	neuron fate specification (GO:0048665)	2.37500711
98	membrane assembly (GO:0071709)	2.36906298
99	cilium movement (GO:0003341)	2.34594793
100	basic amino acid transport (GO:0015802)	2.33972817

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.67394742
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.62809148
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.49810850
4	TRIM28_21343339_ChIP-Seq_HEK293_Human	2.89216732
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.77167362
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.71580497
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.69017460
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.59772268
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.45135395
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.38685950
11	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.27115615
12	P300_19829295_ChIP-Seq_ESCs_Human	2.16319752
13	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.15005116
14	VDR_22108803_ChIP-Seq_LS180_Human	2.03923086
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.02481319
16	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.93851981
17	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.90772592
18	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.88453063
19	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.86676954
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.84299983
21	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.83350186
22	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.79339360
23	EWS_26573619_Chip-Seq_HEK293_Human	1.77846765
24	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.76887579
25	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73303295
26	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.70656699
27	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.69424709
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.68027541
29	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.64824138
30	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.64558644
31	TAF15_26573619_Chip-Seq_HEK293_Human	1.62160445
32	FUS_26573619_Chip-Seq_HEK293_Human	1.57886619
33	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.56945664
34	IGF1R_20145208_ChIP-Seq_DFB_Human	1.53019051
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51212377
36	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.50641701
37	SMAD4_21799915_ChIP-Seq_A2780_Human	1.50252230
38	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.49500361
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44026152
40	ER_23166858_ChIP-Seq_MCF-7_Human	1.42525072
41	TP53_18474530_ChIP-ChIP_U2OS_Human	1.37849014
42	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.36788459
43	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.35838410
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.35803310
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35586264
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.35029934
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34844898
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.34844898
49	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.34051196
50	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.31281588
51	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.31237461
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31036543
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.30846870
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.30534931
55	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.30473020
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29618374
57	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29532284
58	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.27591397
59	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.26836735
60	CJUN_26792858_Chip-Seq_BT549_Human	1.24862008
61	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24037272
62	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23984287
63	TP53_16413492_ChIP-PET_HCT116_Human	1.23289147
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.23120294
65	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.23047434
66	AR_25329375_ChIP-Seq_VCAP_Human	1.22896630
67	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21922745
68	RUNX2_22187159_ChIP-Seq_PCA_Human	1.21291684
69	STAT3_23295773_ChIP-Seq_U87_Human	1.20982445
70	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20580845
71	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.19474954
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18902798
73	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.17913391
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.17501445
75	TCF4_22108803_ChIP-Seq_LS180_Human	1.17142395
76	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.17113363
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16821894
78	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16821894
79	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.15826902
80	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.15217000
81	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.15217000
82	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14712668
83	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14540985
84	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.13893150
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.13729078
86	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.13269767
87	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.13212122
88	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12360701
89	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12360701
90	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.07887269
91	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.06110953
92	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.05070251
93	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.04648580
94	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.03847072
95	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03390844
96	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02765750
97	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02023455
98	TBL1_22424771_ChIP-Seq_293T_Human	1.01383415
99	TCF4_23295773_ChIP-Seq_U87_Human	1.00882691
100	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.00740761

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.07069041
2	MP0005646_abnormal_pituitary_gland	3.33469125
3	MP0010030_abnormal_orbit_morphology	3.12618493
4	MP0003283_abnormal_digestive_organ	3.04408535
5	MP0001346_abnormal_lacrimal_gland	2.94718041
6	MP0003136_yellow_coat_color	2.85383578
7	MP0004133_heterotaxia	2.70768758
8	MP0002102_abnormal_ear_morphology	2.49812766
9	MP0008877_abnormal_DNA_methylation	2.27871860
10	MP0003195_calcinosis	2.26519776
11	MP0006292_abnormal_olfactory_placode	2.24753462
12	MP0003787_abnormal_imprinting	2.16700101
13	MP0008789_abnormal_olfactory_epithelium	2.15821048
14	MP0010386_abnormal_urinary_bladder	2.15616308
15	MP0003950_abnormal_plasma_membrane	2.08985683
16	MP0003011_delayed_dark_adaptation	2.00804824
17	MP0002938_white_spotting	2.00606400
18	MP0002653_abnormal_ependyma_morphology	1.85661274
19	MP0000049_abnormal_middle_ear	1.84812921
20	MP0002928_abnormal_bile_duct	1.83239794
21	MP0002638_abnormal_pupillary_reflex	1.81991149
22	MP0002138_abnormal_hepatobiliary_system	1.74537311
23	MP0000631_abnormal_neuroendocrine_gland	1.65679464
24	MP0000566_synostosis	1.63241386
25	MP0005084_abnormal_gallbladder_morpholo	1.58019528
26	MP0004885_abnormal_endolymph	1.57092538
27	MP0005503_abnormal_tendon_morphology	1.56437199
28	MP0005551_abnormal_eye_electrophysiolog	1.56303095
29	MP0000778_abnormal_nervous_system	1.54979595
30	MP0005499_abnormal_olfactory_system	1.54001738
31	MP0005394_taste/olfaction_phenotype	1.54001738
32	MP0003937_abnormal_limbs/digits/tail_de	1.50521365
33	MP0000372_irregular_coat_pigmentation	1.46531796
34	MP0003880_abnormal_central_pattern	1.46524123
35	MP0001485_abnormal_pinna_reflex	1.44823007
36	MP0006072_abnormal_retinal_apoptosis	1.43474753
37	MP0003252_abnormal_bile_duct	1.42124806
38	MP0003646_muscle_fatigue	1.41010265
39	MP0005248_abnormal_Harderian_gland	1.39027520
40	MP0002095_abnormal_skin_pigmentation	1.37322030
41	MP0002163_abnormal_gland_morphology	1.34259665
42	MP0005195_abnormal_posterior_eye	1.32473191
43	MP0009250_abnormal_appendicular_skeleto	1.28167725
44	MP0002876_abnormal_thyroid_physiology	1.26444622
45	MP0003122_maternal_imprinting	1.25333138
46	MP0000026_abnormal_inner_ear	1.23400564
47	MP0002272_abnormal_nervous_system	1.19043994
48	MP0009384_cardiac_valve_regurgitation	1.18170462
49	MP0005085_abnormal_gallbladder_physiolo	1.17589253
50	MP0001502_abnormal_circadian_rhythm	1.17355155
51	MP0005174_abnormal_tail_pigmentation	1.14816534
52	MP0009745_abnormal_behavioral_response	1.14337735
53	MP0003121_genomic_imprinting	1.12835577
54	MP0002295_abnormal_pulmonary_circulatio	1.11002694
55	MP0001501_abnormal_sleep_pattern	1.10550004
56	MP0005253_abnormal_eye_physiology	1.08207449
57	MP0003942_abnormal_urinary_system	1.07303522
58	MP0000534_abnormal_ureter_morphology	1.07158348
59	MP0002139_abnormal_hepatobiliary_system	1.06016662
60	MP0005423_abnormal_somatic_nervous	1.05586576
61	MP0001299_abnormal_eye_distance/	1.04068578
62	MP0001293_anophthalmia	1.01467442
63	MP0000015_abnormal_ear_pigmentation	0.97627022
64	MP0002557_abnormal_social/conspecific_i	0.97572623
65	MP0001286_abnormal_eye_development	0.97300370
66	MP0008775_abnormal_heart_ventricle	0.95928656
67	MP0003936_abnormal_reproductive_system	0.95228398
68	MP0003755_abnormal_palate_morphology	0.94923745
69	MP0002233_abnormal_nose_morphology	0.94732166
70	MP0005391_vision/eye_phenotype	0.94681005
71	MP0002064_seizures	0.94146286
72	MP0004043_abnormal_pH_regulation	0.94085745
73	MP0006276_abnormal_autonomic_nervous	0.93655197
74	MP0001486_abnormal_startle_reflex	0.93072270
75	MP0002572_abnormal_emotion/affect_behav	0.90114554
76	MP0002734_abnormal_mechanical_nocicepti	0.90016639
77	MP0000538_abnormal_urinary_bladder	0.88930324
78	MP0000647_abnormal_sebaceous_gland	0.87965840
79	MP0008872_abnormal_physiological_respon	0.87953158
80	MP0001873_stomach_inflammation	0.84388210
81	MP0001879_abnormal_lymphatic_vessel	0.80800948
82	MP0001984_abnormal_olfaction	0.79596063
83	MP0002177_abnormal_outer_ear	0.78693348
84	MP0000428_abnormal_craniofacial_morphol	0.78606978
85	MP0001663_abnormal_digestive_system	0.78438390
86	MP0001188_hyperpigmentation	0.77679810
87	MP0002160_abnormal_reproductive_system	0.76999190
88	MP0004142_abnormal_muscle_tone	0.76428164
89	MP0001348_abnormal_lacrimal_gland	0.76419495
90	MP0002752_abnormal_somatic_nervous	0.76414482
91	MP0002277_abnormal_respiratory_mucosa	0.76301312
92	MP0001529_abnormal_vocalization	0.75845299
93	MP0009046_muscle_twitch	0.74249034
94	MP0005197_abnormal_uvea_morphology	0.73582620
95	MP0005187_abnormal_penis_morphology	0.73513532
96	MP0005379_endocrine/exocrine_gland_phen	0.72911536
97	MP0000639_abnormal_adrenal_gland	0.71643742
98	MP0001970_abnormal_pain_threshold	0.71242044
99	MP0002234_abnormal_pharynx_morphology	0.69805379
100	MP0002116_abnormal_craniofacial_bone	0.69762248

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	5.07707084
2	Decreased central vision (HP:0007663)	4.87899275
3	Pendular nystagmus (HP:0012043)	4.50737966
4	Abnormal rod and cone electroretinograms (HP:0008323)	4.49843807
5	Pancreatic cysts (HP:0001737)	4.47365533
6	Pancreatic fibrosis (HP:0100732)	4.37223840
7	Molar tooth sign on MRI (HP:0002419)	4.09535763
8	Abnormality of midbrain morphology (HP:0002418)	4.09535763
9	True hermaphroditism (HP:0010459)	4.04158956
10	Nephronophthisis (HP:0000090)	3.68554137
11	Keratoconus (HP:0000563)	3.65958805
12	Increased corneal curvature (HP:0100692)	3.65958805
13	Concave nail (HP:0001598)	3.61577880
14	Abnormality of the renal medulla (HP:0100957)	3.53190230
15	Dyschromatopsia (HP:0007641)	3.51652953
16	Congenital, generalized hypertrichosis (HP:0004540)	3.38233125
17	Attenuation of retinal blood vessels (HP:0007843)	3.36470677
18	Cystic liver disease (HP:0006706)	3.27972130
19	Oligodactyly (hands) (HP:0001180)	3.12646369
20	Tubular atrophy (HP:0000092)	2.94407043
21	Abolished electroretinogram (ERG) (HP:0000550)	2.87512742
22	Congenital sensorineural hearing impairment (HP:0008527)	2.79954712
23	Medial flaring of the eyebrow (HP:0010747)	2.76594282
24	Facial hemangioma (HP:0000329)	2.71402126
25	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.68242150
26	Absent/shortened dynein arms (HP:0200106)	2.68242150
27	Anencephaly (HP:0002323)	2.58576259
28	Abnormality of the renal cortex (HP:0011035)	2.55291360
29	Median cleft lip (HP:0000161)	2.52326624
30	Bony spicule pigmentary retinopathy (HP:0007737)	2.47467631
31	Maternal diabetes (HP:0009800)	2.37351368
32	Abnormality of the diencephalon (HP:0010662)	2.35227462
33	Bifid tongue (HP:0010297)	2.34034710
34	Anophthalmia (HP:0000528)	2.32054047
35	Type II lissencephaly (HP:0007260)	2.30543946
36	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.29923548
37	Abnormal pancreas size (HP:0012094)	2.24367631
38	Increased number of teeth (HP:0011069)	2.21341492
39	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.21219571
40	Sclerocornea (HP:0000647)	2.18981300
41	Hyperglycinemia (HP:0002154)	2.18656399
42	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.17339352
43	Congenital hepatic fibrosis (HP:0002612)	2.11952793
44	Mesomelia (HP:0003027)	2.11224082
45	Hypoplastic ischia (HP:0003175)	2.08528387
46	Oligodactyly (HP:0012165)	2.07679545
47	Postaxial foot polydactyly (HP:0001830)	2.06270321
48	Abnormal drinking behavior (HP:0030082)	2.01266157
49	Polydipsia (HP:0001959)	2.01266157
50	Severe visual impairment (HP:0001141)	2.00017373
51	Acute necrotizing encephalopathy (HP:0006965)	1.98534414
52	Septo-optic dysplasia (HP:0100842)	1.95859483
53	Dyskinesia (HP:0100660)	1.91865995
54	Increased hepatocellular lipid droplets (HP:0006565)	1.90544221
55	Postaxial hand polydactyly (HP:0001162)	1.89881029
56	Hyperventilation (HP:0002883)	1.88837921
57	Abnormal biliary tract physiology (HP:0012439)	1.88405957
58	Bile duct proliferation (HP:0001408)	1.88405957
59	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.88024045
60	Furrowed tongue (HP:0000221)	1.86805094
61	Anterior segment dysgenesis (HP:0007700)	1.85564620
62	Preaxial hand polydactyly (HP:0001177)	1.84569978
63	Hypoplasia of the uterus (HP:0000013)	1.84034203
64	Short hallux (HP:0010109)	1.81676184
65	Tubulointerstitial nephritis (HP:0001970)	1.81221133
66	Male pseudohermaphroditism (HP:0000037)	1.79332419
67	Tubulointerstitial abnormality (HP:0001969)	1.79209985
68	Abnormality of the middle phalanges of the toes (HP:0010183)	1.78707161
69	Occipital encephalocele (HP:0002085)	1.78155352
70	Dandy-Walker malformation (HP:0001305)	1.77377549
71	Chorioretinal atrophy (HP:0000533)	1.75943860
72	Colon cancer (HP:0003003)	1.75773928
73	Febrile seizures (HP:0002373)	1.74928845
74	Polyuria (HP:0000103)	1.74880977
75	Narrow forehead (HP:0000341)	1.74809367
76	Abnormality of the ischium (HP:0003174)	1.73767655
77	Hypoplasia of the ulna (HP:0003022)	1.72789632
78	Azoospermia (HP:0000027)	1.72686516
79	Shawl scrotum (HP:0000049)	1.71879721
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.71262538
81	Large for gestational age (HP:0001520)	1.70269265
82	Abnormality of the axillary hair (HP:0100134)	1.70025024
83	Abnormality of secondary sexual hair (HP:0009888)	1.70025024
84	Abnormality of the vertebral endplates (HP:0005106)	1.69220012
85	Neoplasm of the adrenal cortex (HP:0100641)	1.68767140
86	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68461768
87	Abnormal respiratory epithelium morphology (HP:0012253)	1.68461768
88	Progressive macrocephaly (HP:0004481)	1.68351966
89	Congenital primary aphakia (HP:0007707)	1.67168007
90	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67049139
91	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.66256909
92	Gait imbalance (HP:0002141)	1.65926331
93	Stenosis of the external auditory canal (HP:0000402)	1.65716480
94	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.65684853
95	Fibular hypoplasia (HP:0003038)	1.65572273
96	Thyroid-stimulating hormone excess (HP:0002925)	1.64722020
97	Vitreoretinal degeneration (HP:0000655)	1.64259761
98	Tubulointerstitial fibrosis (HP:0005576)	1.63465879
99	Left ventricular hypertrophy (HP:0001712)	1.63452196
100	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.62030645

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.53006947
2	PNCK	3.49097785
3	NUAK1	3.20364483
4	ZAK	3.04847193
5	BMPR1B	2.77216984
6	GRK1	2.77105982
7	ADRBK2	2.70610090
8	PINK1	2.56681342
9	MAP4K2	2.21013304
10	CASK	2.04472019
11	EPHB2	1.94882891
12	WEE1	1.89287787
13	WNK3	1.86444855
14	EPHA4	1.84363616
15	BCR	1.84207529
16	PLK2	1.78494012
17	TNIK	1.63493295
18	TIE1	1.55758443
19	MAPK15	1.52663182
20	MAP3K4	1.52507354
21	TAOK3	1.51070673
22	WNK4	1.49035763
23	STK39	1.46438376
24	NTRK3	1.41020323
25	PAK3	1.38438816
26	INSRR	1.27580678
27	STK24	1.27376075
28	ACVR1B	1.25955102
29	MAPK13	1.23491130
30	PIK3CA	1.16149592
31	PASK	1.15712084
32	PLK3	1.14356214
33	LMTK2	1.11488458
34	ADRBK1	1.11212414
35	NEK1	1.10695991
36	PRKCE	1.05629887
37	PRKD2	1.05310520
38	PRKCG	1.02467214
39	MAP2K7	1.01035907
40	BRSK2	0.96270524
41	DDR2	0.92684993
42	MKNK2	0.92615310
43	TGFBR1	0.91454132
44	BCKDK	0.89284461
45	FGFR2	0.88283631
46	OXSR1	0.88217451
47	PRKCH	0.85754321
48	PLK4	0.83232884
49	PKN1	0.79845150
50	PRKCQ	0.77774130
51	DYRK2	0.76908484
52	DMPK	0.75745859
53	NEK9	0.74529660
54	PTK2B	0.74176163
55	CAMK2A	0.70289380
56	PRKD3	0.67649886
57	PRKACA	0.67536589
58	ILK	0.65092010
59	PRKG1	0.64953044
60	MUSK	0.64202057
61	CAMK2D	0.63457082
62	VRK1	0.62971849
63	NLK	0.62681557
64	ERBB3	0.62621163
65	PLK1	0.62432535
66	LRRK2	0.60585120
67	MAP3K10	0.60438366
68	CAMK1	0.58074395
69	CDC7	0.57108104
70	MYLK	0.56252069
71	TAF1	0.55359255
72	OBSCN	0.52968401
73	CAMK1G	0.50544794
74	LIMK1	0.47574394
75	NTRK2	0.45418654
76	MKNK1	0.45275425
77	GSK3A	0.44776275
78	FGFR1	0.44319744
79	CSNK2A1	0.42753080
80	VRK2	0.41727947
81	PRKCA	0.41407877
82	IRAK1	0.41223382
83	ROCK1	0.39432362
84	STK11	0.38682754
85	MAP2K1	0.38593330
86	ERBB2	0.38111669
87	AURKB	0.38065680
88	PRKCZ	0.38007989
89	FER	0.36771609
90	CDK8	0.35655780
91	CSNK2A2	0.34037912
92	MST4	0.32182176
93	PRKACB	0.31836141
94	FLT3	0.31481073
95	GRK7	0.31375828
96	CSNK1A1	0.30872590
97	KSR1	0.30729016
98	DAPK2	0.30718409
99	CSNK1E	0.30075354
100	DAPK3	0.28613896

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.31851049
2	Selenocompound metabolism_Homo sapiens_hsa00450	2.85613651
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.65272266
4	Ribosome_Homo sapiens_hsa03010	2.60342372
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.42029923
6	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36871417
7	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.19793368
8	Phototransduction_Homo sapiens_hsa04744	2.18523690
9	Basal cell carcinoma_Homo sapiens_hsa05217	2.17634997
10	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.16552304
11	Protein export_Homo sapiens_hsa03060	2.01687555
12	Butanoate metabolism_Homo sapiens_hsa00650	1.97442801
13	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.91424562
14	Nicotine addiction_Homo sapiens_hsa05033	1.87448663
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84417262
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.82208853
17	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74228286
18	Basal transcription factors_Homo sapiens_hsa03022	1.69334760
19	Sulfur relay system_Homo sapiens_hsa04122	1.61345500
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.52102901
21	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.48873292
22	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.46046108
23	Insulin secretion_Homo sapiens_hsa04911	1.44583009
24	RNA polymerase_Homo sapiens_hsa03020	1.40905286
25	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.39658951
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38493079
27	Parkinsons disease_Homo sapiens_hsa05012	1.31503357
28	Cardiac muscle contraction_Homo sapiens_hsa04260	1.30421880
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.28604572
30	Retinol metabolism_Homo sapiens_hsa00830	1.21899053
31	Mineral absorption_Homo sapiens_hsa04978	1.20169352
32	RNA degradation_Homo sapiens_hsa03018	1.15974174
33	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.14712438
34	Wnt signaling pathway_Homo sapiens_hsa04310	1.14130039
35	Linoleic acid metabolism_Homo sapiens_hsa00591	1.12146550
36	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11295981
37	Huntingtons disease_Homo sapiens_hsa05016	1.10362262
38	Homologous recombination_Homo sapiens_hsa03440	1.08139154
39	Circadian rhythm_Homo sapiens_hsa04710	1.05906153
40	Cocaine addiction_Homo sapiens_hsa05030	1.05038815
41	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03456797
42	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.01391377
43	Taste transduction_Homo sapiens_hsa04742	0.97339521
44	Olfactory transduction_Homo sapiens_hsa04740	0.97285359
45	Morphine addiction_Homo sapiens_hsa05032	0.97221626
46	Ether lipid metabolism_Homo sapiens_hsa00565	0.96519304
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.96502564
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.94333958
49	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.92902572
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.90838949
51	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.90502269
52	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.90087974
53	Propanoate metabolism_Homo sapiens_hsa00640	0.87369733
54	Alzheimers disease_Homo sapiens_hsa05010	0.86833064
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.85126563
56	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.84271726
57	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83103883
58	Regulation of autophagy_Homo sapiens_hsa04140	0.78241608
59	ABC transporters_Homo sapiens_hsa02010	0.77206156
60	Bile secretion_Homo sapiens_hsa04976	0.76718356
61	Melanogenesis_Homo sapiens_hsa04916	0.75958033
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75672939
63	One carbon pool by folate_Homo sapiens_hsa00670	0.75459946
64	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73869136
65	Salivary secretion_Homo sapiens_hsa04970	0.73755267
66	Caffeine metabolism_Homo sapiens_hsa00232	0.72755624
67	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.72476256
68	Fatty acid degradation_Homo sapiens_hsa00071	0.72339923
69	Gastric acid secretion_Homo sapiens_hsa04971	0.72152256
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.71073784
71	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.70769685
72	Circadian entrainment_Homo sapiens_hsa04713	0.70517247
73	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.70307440
74	Pancreatic secretion_Homo sapiens_hsa04972	0.70110861
75	GABAergic synapse_Homo sapiens_hsa04727	0.68403927
76	Mismatch repair_Homo sapiens_hsa03430	0.65816107
77	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.63180759
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.62845024
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.61716876
80	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.59345197
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.59294961
82	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.58211338
83	Metabolic pathways_Homo sapiens_hsa01100	0.57875775
84	Melanoma_Homo sapiens_hsa05218	0.56760798
85	Serotonergic synapse_Homo sapiens_hsa04726	0.56332121
86	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56307404
87	Peroxisome_Homo sapiens_hsa04146	0.54713228
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.50816731
89	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.49479604
90	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48592435
91	Sphingolipid metabolism_Homo sapiens_hsa00600	0.48513588
92	Steroid biosynthesis_Homo sapiens_hsa00100	0.47765457
93	cAMP signaling pathway_Homo sapiens_hsa04024	0.46694542
94	Base excision repair_Homo sapiens_hsa03410	0.46179872
95	Dopaminergic synapse_Homo sapiens_hsa04728	0.44325998
96	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.43980709
97	Pyrimidine metabolism_Homo sapiens_hsa00240	0.43799796
98	Folate biosynthesis_Homo sapiens_hsa00790	0.43682678
99	Fat digestion and absorption_Homo sapiens_hsa04975	0.42239124
100	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.40368474

FAM133CP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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