ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.43638593
2	ATP synthesis coupled proton transport (GO:0015986)	5.80725185
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.80725185
4	viral transcription (GO:0019083)	5.57735612
5	translational termination (GO:0006415)	5.48822584
6	ribosomal small subunit biogenesis (GO:0042274)	5.36079297
7	chaperone-mediated protein transport (GO:0072321)	5.34644571
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.96392576
9	cotranslational protein targeting to membrane (GO:0006613)	4.95998279
10	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.95731672
11	protein targeting to ER (GO:0045047)	4.90424420
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.71984439
13	translational elongation (GO:0006414)	4.62282874
14	protein localization to endoplasmic reticulum (GO:0070972)	4.60333306
15	respiratory electron transport chain (GO:0022904)	4.57235035
16	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.53795689
17	ribosomal small subunit assembly (GO:0000028)	4.53373462
18	electron transport chain (GO:0022900)	4.51940105
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.50753161
20	NADH dehydrogenase complex assembly (GO:0010257)	4.50753161
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.50753161
22	protein complex biogenesis (GO:0070271)	4.40223306
23	protein-cofactor linkage (GO:0018065)	4.33865393
24	maturation of SSU-rRNA (GO:0030490)	4.32580003
25	ribosomal large subunit biogenesis (GO:0042273)	4.30848952
26	mitochondrial respiratory chain complex assembly (GO:0033108)	4.28206728
27	cellular protein complex disassembly (GO:0043624)	4.15389941
28	viral life cycle (GO:0019058)	4.11529921
29	translational initiation (GO:0006413)	3.96584958
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.93606417
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.91069395
32	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.91069395
33	translation (GO:0006412)	3.88853400
34	protein neddylation (GO:0045116)	3.88100156
35	DNA deamination (GO:0045006)	3.86605343
36	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.74869645
37	organelle disassembly (GO:1903008)	3.74167938
38	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.68518443
39	termination of RNA polymerase III transcription (GO:0006386)	3.68518443
40	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.62196749
41	behavioral response to nicotine (GO:0035095)	3.55254793
42	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.53045350
43	cellular component biogenesis (GO:0044085)	3.46843578
44	ribonucleoprotein complex biogenesis (GO:0022613)	3.42884420
45	protein complex disassembly (GO:0043241)	3.42611662
46	macromolecular complex disassembly (GO:0032984)	3.40042920
47	proteasome assembly (GO:0043248)	3.36899484
48	respiratory chain complex IV assembly (GO:0008535)	3.33007959
49	ATP biosynthetic process (GO:0006754)	3.25812611
50	protein targeting to membrane (GO:0006612)	3.25440480
51	fusion of sperm to egg plasma membrane (GO:0007342)	3.17769033
52	centriole replication (GO:0007099)	3.17095831
53	chromatin remodeling at centromere (GO:0031055)	3.13232483
54	water-soluble vitamin biosynthetic process (GO:0042364)	3.11104040
55	hydrogen ion transmembrane transport (GO:1902600)	3.10023843
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.08782089
57	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08554266
58	rRNA metabolic process (GO:0016072)	3.07129802
59	rRNA processing (GO:0006364)	3.07108698
60	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.06953109
61	ribonucleoprotein complex disassembly (GO:0032988)	3.06392405
62	CENP-A containing nucleosome assembly (GO:0034080)	3.03887776
63	cullin deneddylation (GO:0010388)	3.03349070
64	protein deneddylation (GO:0000338)	2.97789058
65	pyrimidine nucleotide catabolic process (GO:0006244)	2.96708778
66	positive regulation of action potential (GO:0045760)	2.95521551
67	mRNA catabolic process (GO:0006402)	2.93598398
68	proton transport (GO:0015992)	2.88811782
69	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.88387741
70	cytochrome complex assembly (GO:0017004)	2.87179210
71	base-excision repair, AP site formation (GO:0006285)	2.84459248
72	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.82815734
73	hydrogen transport (GO:0006818)	2.81921099
74	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.81452057
75	regulation of mitotic spindle checkpoint (GO:1903504)	2.81452057
76	tRNA processing (GO:0008033)	2.81304066
77	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.78089597
78	intracellular protein transmembrane import (GO:0044743)	2.76775826
79	protein targeting to mitochondrion (GO:0006626)	2.74577196
80	histone mRNA metabolic process (GO:0008334)	2.74373716
81	neuronal action potential (GO:0019228)	2.73553733
82	RNA catabolic process (GO:0006401)	2.72981403
83	protein localization to mitochondrion (GO:0070585)	2.72965859
84	spliceosomal complex assembly (GO:0000245)	2.70776505
85	DNA damage response, detection of DNA damage (GO:0042769)	2.70709517
86	rRNA catabolic process (GO:0016075)	2.70225013
87	histone exchange (GO:0043486)	2.66964355
88	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.59576861
89	establishment of protein localization to mitochondrion (GO:0072655)	2.59090884
90	L-fucose catabolic process (GO:0042355)	2.56778647
91	fucose catabolic process (GO:0019317)	2.56778647
92	L-fucose metabolic process (GO:0042354)	2.56778647
93	negative regulation of telomere maintenance (GO:0032205)	2.56497291
94	regulation of cilium movement (GO:0003352)	2.55185141
95	protein peptidyl-prolyl isomerization (GO:0000413)	2.54171300
96	kynurenine metabolic process (GO:0070189)	2.53387730
97	inner mitochondrial membrane organization (GO:0007007)	2.53328272
98	recombinational repair (GO:0000725)	2.52797359
99	mitochondrion morphogenesis (GO:0070584)	2.51679157
100	plasma membrane fusion (GO:0045026)	2.50959899

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.33097731
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.15434928
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.56859019
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.55454479
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.08531439
6	VDR_22108803_ChIP-Seq_LS180_Human	3.07371718
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.99811437
8	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.84142607
9	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.63721020
10	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58789583
11	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57413279
12	ELK1_19687146_ChIP-ChIP_HELA_Human	2.51051286
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.49794605
14	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.44222670
15	EZH2_22144423_ChIP-Seq_EOC_Human	2.43869004
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32240690
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.24171641
18	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.13469095
19	GBX2_23144817_ChIP-Seq_PC3_Human	2.10598876
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.10591938
21	EWS_26573619_Chip-Seq_HEK293_Human	2.07208965
22	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.05363909
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.00585710
24	MYC_18940864_ChIP-ChIP_HL60_Human	1.97003826
25	FUS_26573619_Chip-Seq_HEK293_Human	1.95307091
26	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.93710180
27	FOXP3_21729870_ChIP-Seq_TREG_Human	1.89670401
28	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85923522
29	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82529321
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.82178383
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.77834260
32	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.73884715
33	IGF1R_20145208_ChIP-Seq_DFB_Human	1.65908851
34	P300_19829295_ChIP-Seq_ESCs_Human	1.65341093
35	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63871806
36	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.57636488
37	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.57348101
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56852943
39	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.53020752
40	TTF2_22483619_ChIP-Seq_HELA_Human	1.52975611
41	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.50716531
42	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.50111446
43	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.47472584
44	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.46947719
45	IRF1_19129219_ChIP-ChIP_H3396_Human	1.46442472
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.43843024
47	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.43520736
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.39664512
49	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39418909
50	TP53_22573176_ChIP-Seq_HFKS_Human	1.39010190
51	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38223852
52	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.38188157
53	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.30401405
54	* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.29184069
55	DCP1A_22483619_ChIP-Seq_HELA_Human	1.26249621
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.25952499
57	ER_23166858_ChIP-Seq_MCF-7_Human	1.25752040
58	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.24435775
59	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23395420
60	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.20180401
61	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.19773404
62	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.18805630
63	RNF2_27304074_Chip-Seq_NSC_Mouse	1.15669407
64	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.14855995
65	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.12920588
66	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.12746266
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.11451689
68	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.10384194
69	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.10384194
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.09985627
71	NANOG_19829295_ChIP-Seq_ESCs_Human	1.09985627
72	GABP_19822575_ChIP-Seq_HepG2_Human	1.09064852
73	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07112468
74	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.06698643
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.06102056
76	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.06102056
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04463329
78	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03829541
79	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.02804655
80	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.02798651
81	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.02730838
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.01847152
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.01742101
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.96744228
85	XRN2_22483619_ChIP-Seq_HELA_Human	0.96604852
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.96467491
87	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96074133
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.95705395
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.95690073
90	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.94568737
91	AR_20517297_ChIP-Seq_VCAP_Human	0.90600141
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90473294
93	NCOR_22424771_ChIP-Seq_293T_Human	0.89799857
94	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.86436046
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.85476939
96	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.85432512
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85358942
98	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.85358942
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.83959055
100	AR_25329375_ChIP-Seq_VCAP_Human	0.82975666

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.84989920
2	MP0003806_abnormal_nucleotide_metabolis	3.13789862
3	MP0006292_abnormal_olfactory_placode	2.95903613
4	MP0008877_abnormal_DNA_methylation	2.88702970
5	MP0002638_abnormal_pupillary_reflex	2.74480255
6	MP0003787_abnormal_imprinting	2.47140222
7	MP0002938_white_spotting	2.34303101
8	MP0004142_abnormal_muscle_tone	2.30406401
9	MP0000569_abnormal_digit_pigmentation	2.16274782
10	MP0004133_heterotaxia	2.06302063
11	MP0005174_abnormal_tail_pigmentation	2.01189474
12	MP0006072_abnormal_retinal_apoptosis	1.95166303
13	MP0004147_increased_porphyrin_level	1.84753891
14	MP0003195_calcinosis	1.71865181
15	MP0001485_abnormal_pinna_reflex	1.70552538
16	MP0002102_abnormal_ear_morphology	1.70350911
17	MP0003136_yellow_coat_color	1.70068158
18	MP0000372_irregular_coat_pigmentation	1.68309803
19	MP0005646_abnormal_pituitary_gland	1.68261165
20	MP0006036_abnormal_mitochondrial_physio	1.65162284
21	MP0009697_abnormal_copulation	1.61065541
22	MP0002837_dystrophic_cardiac_calcinosis	1.60107181
23	MP0001529_abnormal_vocalization	1.59177560
24	MP0009046_muscle_twitch	1.57854343
25	MP0008058_abnormal_DNA_repair	1.56452475
26	MP0001905_abnormal_dopamine_level	1.53163645
27	MP0006276_abnormal_autonomic_nervous	1.51752389
28	MP0005551_abnormal_eye_electrophysiolog	1.48523026
29	MP0002095_abnormal_skin_pigmentation	1.48034994
30	MP0001188_hyperpigmentation	1.47405469
31	MP0003121_genomic_imprinting	1.45101523
32	MP0008872_abnormal_physiological_respon	1.44702028
33	MP0005389_reproductive_system_phenotype	1.44248431
34	MP0008875_abnormal_xenobiotic_pharmacok	1.39334619
35	MP0005671_abnormal_response_to	1.38713095
36	MP0001293_anophthalmia	1.33335228
37	MP0003718_maternal_effect	1.31390912
38	MP0003186_abnormal_redox_activity	1.31312357
39	MP0000631_abnormal_neuroendocrine_gland	1.30638319
40	MP0002234_abnormal_pharynx_morphology	1.30086860
41	MP0009745_abnormal_behavioral_response	1.29180273
42	MP0008789_abnormal_olfactory_epithelium	1.28866145
43	MP0002277_abnormal_respiratory_mucosa	1.28349754
44	MP0005075_abnormal_melanosome_morpholog	1.28179082
45	MP0004145_abnormal_muscle_electrophysio	1.26536175
46	MP0001919_abnormal_reproductive_system	1.25289724
47	MP0001984_abnormal_olfaction	1.24827144
48	MP0005253_abnormal_eye_physiology	1.23728544
49	MP0003011_delayed_dark_adaptation	1.17913172
50	MP0002736_abnormal_nociception_after	1.17266137
51	MP0004885_abnormal_endolymph	1.16293750
52	MP0002160_abnormal_reproductive_system	1.15231338
53	MP0002272_abnormal_nervous_system	1.14420599
54	MP0001986_abnormal_taste_sensitivity	1.12309564
55	MP0003283_abnormal_digestive_organ	1.11348246
56	MP0001968_abnormal_touch/_nociception	1.11110589
57	MP0000049_abnormal_middle_ear	1.07171610
58	MP0000015_abnormal_ear_pigmentation	1.06879395
59	MP0010094_abnormal_chromosome_stability	1.05667380
60	MP0003693_abnormal_embryo_hatching	1.03259480
61	MP0004742_abnormal_vestibular_system	1.01304750
62	MP0002876_abnormal_thyroid_physiology	1.00344894
63	MP0005408_hypopigmentation	0.99495209
64	MP0005084_abnormal_gallbladder_morpholo	0.99487931
65	MP0001486_abnormal_startle_reflex	0.98316426
66	MP0003880_abnormal_central_pattern	0.97861982
67	MP0005394_taste/olfaction_phenotype	0.94171988
68	MP0005499_abnormal_olfactory_system	0.94171988
69	MP0004043_abnormal_pH_regulation	0.93787812
70	MP0010030_abnormal_orbit_morphology	0.92699582
71	MP0002138_abnormal_hepatobiliary_system	0.91367065
72	MP0002928_abnormal_bile_duct	0.89477544
73	MP0003122_maternal_imprinting	0.87769069
74	MP0002210_abnormal_sex_determination	0.87057836
75	MP0003786_premature_aging	0.86322318
76	MP0001764_abnormal_homeostasis	0.85407041
77	MP0006035_abnormal_mitochondrial_morpho	0.85286798
78	MP0002064_seizures	0.84297299
79	MP0008007_abnormal_cellular_replicative	0.83919894
80	MP0003137_abnormal_impulse_conducting	0.82908402
81	MP0003567_abnormal_fetal_cardiomyocyte	0.82509004
82	MP0002572_abnormal_emotion/affect_behav	0.81751611
83	MP0005332_abnormal_amino_acid	0.81693416
84	MP0001324_abnormal_eye_pigmentation	0.81051659
85	MP0003937_abnormal_limbs/digits/tail_de	0.80225952
86	MP0001440_abnormal_grooming_behavior	0.80050183
87	MP0005195_abnormal_posterior_eye	0.79892574
88	MP0001853_heart_inflammation	0.78961866
89	MP0005367_renal/urinary_system_phenotyp	0.78564943
90	MP0000516_abnormal_urinary_system	0.78564943
91	MP0002163_abnormal_gland_morphology	0.75488851
92	MP0001929_abnormal_gametogenesis	0.73743587
93	MP0004957_abnormal_blastocyst_morpholog	0.73354943
94	MP0002177_abnormal_outer_ear	0.69965557
95	MP0001873_stomach_inflammation	0.69566270
96	MP0005636_abnormal_mineral_homeostasis	0.68662733
97	MP0003077_abnormal_cell_cycle	0.68499369
98	MP0004215_abnormal_myocardial_fiber	0.67535393
99	MP0002067_abnormal_sensory_capabilities	0.67515384
100	MP0008961_abnormal_basal_metabolism	0.66163797

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	5.03157343
2	Mitochondrial inheritance (HP:0001427)	4.47906179
3	Abnormal mitochondria in muscle tissue (HP:0008316)	4.39086075
4	Acute encephalopathy (HP:0006846)	4.36213691
5	Increased hepatocellular lipid droplets (HP:0006565)	4.23431116
6	Progressive macrocephaly (HP:0004481)	4.18899282
7	3-Methylglutaconic aciduria (HP:0003535)	4.01412575
8	Increased CSF lactate (HP:0002490)	3.93466271
9	Lipid accumulation in hepatocytes (HP:0006561)	3.87353605
10	Molar tooth sign on MRI (HP:0002419)	3.84659842
11	Abnormality of midbrain morphology (HP:0002418)	3.84659842
12	Pancreatic cysts (HP:0001737)	3.68038200
13	Congenital, generalized hypertrichosis (HP:0004540)	3.59366289
14	Hepatocellular necrosis (HP:0001404)	3.55579326
15	Renal Fanconi syndrome (HP:0001994)	3.36950914
16	Abnormality of cells of the erythroid lineage (HP:0012130)	3.34075801
17	Cerebral edema (HP:0002181)	3.32060099
18	Exertional dyspnea (HP:0002875)	3.26296719
19	Hepatic necrosis (HP:0002605)	3.22197044
20	Macrocytic anemia (HP:0001972)	3.17680981
21	Abnormal number of erythroid precursors (HP:0012131)	3.08054011
22	Pancreatic fibrosis (HP:0100732)	3.03305501
23	Reticulocytopenia (HP:0001896)	3.01745227
24	Abnormality of alanine metabolism (HP:0010916)	2.98133848
25	Hyperalaninemia (HP:0003348)	2.98133848
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.98133848
27	True hermaphroditism (HP:0010459)	2.91010966
28	Increased intramyocellular lipid droplets (HP:0012240)	2.86545517
29	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.78966354
30	Medial flaring of the eyebrow (HP:0010747)	2.75414801
31	Abnormality of renal resorption (HP:0011038)	2.73848956
32	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.67120553
33	Nephronophthisis (HP:0000090)	2.59000724
34	Increased serum lactate (HP:0002151)	2.53008124
35	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.49700107
36	Congenital stationary night blindness (HP:0007642)	2.47638502
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.47257599
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.47257599
39	Aplastic anemia (HP:0001915)	2.46941761
40	Lactic acidosis (HP:0003128)	2.45815761
41	Short tibia (HP:0005736)	2.42177602
42	Respiratory difficulties (HP:0002880)	2.38096725
43	Optic disc pallor (HP:0000543)	2.36558021
44	Increased muscle lipid content (HP:0009058)	2.32143434
45	Leukodystrophy (HP:0002415)	2.27422009
46	Gait imbalance (HP:0002141)	2.26077143
47	Pallor (HP:0000980)	2.26070111
48	Respiratory failure (HP:0002878)	2.24423287
49	Congenital primary aphakia (HP:0007707)	2.22863385
50	Exercise intolerance (HP:0003546)	2.20249751
51	Abnormality of urine glucose concentration (HP:0011016)	2.14522168
52	Glycosuria (HP:0003076)	2.14522168
53	Abnormality of the renal medulla (HP:0100957)	2.12204549
54	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.10505372
55	Sclerocornea (HP:0000647)	2.10258014
56	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.04708416
57	Lethargy (HP:0001254)	2.02090578
58	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.00982112
59	Nephrogenic diabetes insipidus (HP:0009806)	1.98421123
60	Hypoplasia of the radius (HP:0002984)	1.97691806
61	Male pseudohermaphroditism (HP:0000037)	1.97087698
62	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.95694865
63	Abnormality of the renal cortex (HP:0011035)	1.94641475
64	Hypoplasia of the pons (HP:0012110)	1.92694930
65	Cystic liver disease (HP:0006706)	1.92358399
66	Enlarged epiphyses (HP:0010580)	1.91876509
67	Furrowed tongue (HP:0000221)	1.87595033
68	Abnormality of the pons (HP:0007361)	1.87039919
69	Volvulus (HP:0002580)	1.86354075
70	CNS demyelination (HP:0007305)	1.84960525
71	Abolished electroretinogram (ERG) (HP:0000550)	1.84429174
72	Small hand (HP:0200055)	1.83907114
73	Absent thumb (HP:0009777)	1.83442016
74	Methylmalonic acidemia (HP:0002912)	1.81769741
75	Hypothermia (HP:0002045)	1.80925954
76	Chronic hepatic failure (HP:0100626)	1.78972739
77	Rib fusion (HP:0000902)	1.76315916
78	Hyperphosphaturia (HP:0003109)	1.75090520
79	Bile duct proliferation (HP:0001408)	1.74712342
80	Abnormal biliary tract physiology (HP:0012439)	1.74712342
81	Renal cortical cysts (HP:0000803)	1.73325659
82	Genital tract atresia (HP:0001827)	1.72776174
83	Colon cancer (HP:0003003)	1.72531382
84	Triphalangeal thumb (HP:0001199)	1.71997091
85	Abnormal respiratory motile cilium morphology (HP:0005938)	1.71700018
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.71700018
87	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71602088
88	Median cleft lip (HP:0000161)	1.70310556
89	Vaginal atresia (HP:0000148)	1.68234910
90	Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)	1.68059736
91	Aplasia/hypoplasia of the uterus (HP:0008684)	1.67336972
92	Cleft eyelid (HP:0000625)	1.66518720
93	Short hallux (HP:0010109)	1.66491446
94	Stenosis of the external auditory canal (HP:0000402)	1.65690347
95	Supernumerary spleens (HP:0009799)	1.64993109
96	Abnormality of serum amino acid levels (HP:0003112)	1.64533157
97	X-linked dominant inheritance (HP:0001423)	1.63877021
98	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.62744494
99	Hyperventilation (HP:0002883)	1.60256694
100	Concave nail (HP:0001598)	1.59831596

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NUAK1	2.79302395
2	TLK1	2.62151105
3	STK16	2.47001810
4	BMPR1B	2.40659953
5	ZAK	2.32961161
6	TAOK3	2.27461703
7	WNK3	2.07141197
8	BUB1	2.02349343
9	MAP4K2	2.01208821
10	ADRBK2	2.00159078
11	GRK1	1.92590055
12	CDC7	1.83303102
13	FRK	1.83220687
14	MKNK2	1.79670269
15	PDK2	1.76077519
16	EIF2AK3	1.67253704
17	WEE1	1.64672208
18	VRK1	1.64588354
19	NEK1	1.57716679
20	PASK	1.54654635
21	VRK2	1.53271982
22	MST4	1.50768990
23	WNK4	1.42407125
24	MAP3K4	1.42381067
25	PLK4	1.38776926
26	MKNK1	1.31828923
27	MAP3K12	1.21191644
28	MAP2K7	1.19244237
29	ACVR1B	1.17170266
30	PHKG2	1.16143953
31	PHKG1	1.16143953
32	KIT	1.13876697
33	OXSR1	1.13665152
34	NME1	1.11616602
35	SRPK1	1.10432465
36	BRSK2	1.09878870
37	PNCK	1.09515214
38	CCNB1	1.08899787
39	PLK1	1.07770500
40	PIK3CA	1.07537420
41	DYRK2	1.07076442
42	EIF2AK1	1.06853711
43	TEC	1.06282720
44	PLK3	1.05080495
45	INSRR	1.01963341
46	STK39	1.00557338
47	PINK1	0.99440846
48	PIM2	0.97817510
49	TRIM28	0.94504907
50	SIK2	0.93178766
51	MAPK13	0.90659216
52	RPS6KA4	0.86995879
53	CDK19	0.85900067
54	RPS6KA5	0.84473680
55	TESK2	0.82702391
56	FLT3	0.82114255
57	BCKDK	0.81207050
58	ERBB3	0.81195044
59	TGFBR1	0.79094224
60	NTRK3	0.75435596
61	MATK	0.74791369
62	MAPK15	0.73834205
63	EIF2AK2	0.73806302
64	CHEK2	0.73546360
65	TNIK	0.73229322
66	AURKB	0.70327405
67	TAF1	0.69535219
68	CASK	0.69504522
69	PIK3CG	0.67269319
70	PRKCG	0.66273711
71	MARK3	0.66192424
72	IKBKB	0.63998343
73	CSNK2A1	0.63848437
74	CSNK1G3	0.63552956
75	ADRBK1	0.63155711
76	PLK2	0.62588244
77	CSNK1G2	0.62217169
78	CSNK2A2	0.60609789
79	ITK	0.60598956
80	TXK	0.56105761
81	LIMK1	0.51366139
82	CSNK1G1	0.50962253
83	PRKCE	0.50788542
84	CDK3	0.49672978
85	TIE1	0.46908736
86	DMPK	0.46233484
87	NEK2	0.45911376
88	PRKACA	0.45601365
89	PRKG1	0.45571977
90	ATR	0.45023287
91	CHUK	0.43228791
92	PRKCQ	0.40566497
93	CSNK1E	0.40407181
94	BMPR2	0.38380465
95	PIM1	0.38236518
96	ERBB2	0.38108465
97	OBSCN	0.37939324
98	CDK8	0.36666975
99	DAPK3	0.36324025
100	ATM	0.34810232

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.22012562
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.28137561
3	Parkinsons disease_Homo sapiens_hsa05012	3.68042665
4	Protein export_Homo sapiens_hsa03060	3.54300578
5	Proteasome_Homo sapiens_hsa03050	2.99140121
6	Homologous recombination_Homo sapiens_hsa03440	2.61103924
7	Huntingtons disease_Homo sapiens_hsa05016	2.48100413
8	Alzheimers disease_Homo sapiens_hsa05010	2.44277254
9	RNA polymerase_Homo sapiens_hsa03020	2.26418172
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.15014573
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.13923799
12	Basal transcription factors_Homo sapiens_hsa03022	2.01016686
13	Selenocompound metabolism_Homo sapiens_hsa00450	1.88503706
14	Cardiac muscle contraction_Homo sapiens_hsa04260	1.86026491
15	Nucleotide excision repair_Homo sapiens_hsa03420	1.85819680
16	Asthma_Homo sapiens_hsa05310	1.82796843
17	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.80165208
18	RNA degradation_Homo sapiens_hsa03018	1.72842667
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71976554
20	Fanconi anemia pathway_Homo sapiens_hsa03460	1.63914029
21	Mismatch repair_Homo sapiens_hsa03430	1.63910972
22	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.59196197
23	Phototransduction_Homo sapiens_hsa04744	1.47193585
24	DNA replication_Homo sapiens_hsa03030	1.46656488
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.31283870
26	Base excision repair_Homo sapiens_hsa03410	1.30990636
27	Spliceosome_Homo sapiens_hsa03040	1.26409953
28	One carbon pool by folate_Homo sapiens_hsa00670	1.25187764
29	Allograft rejection_Homo sapiens_hsa05330	1.24678142
30	Propanoate metabolism_Homo sapiens_hsa00640	1.22670335
31	Pyrimidine metabolism_Homo sapiens_hsa00240	1.20923105
32	Regulation of autophagy_Homo sapiens_hsa04140	1.20746348
33	Graft-versus-host disease_Homo sapiens_hsa05332	1.19999399
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.16476829
35	Folate biosynthesis_Homo sapiens_hsa00790	1.14804523
36	Type I diabetes mellitus_Homo sapiens_hsa04940	1.14382024
37	Butanoate metabolism_Homo sapiens_hsa00650	1.12481275
38	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.10507194
39	RNA transport_Homo sapiens_hsa03013	1.08080124
40	Nicotine addiction_Homo sapiens_hsa05033	1.01497360
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00526399
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.98698014
43	Purine metabolism_Homo sapiens_hsa00230	0.97886314
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.97590369
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.89965795
46	Sulfur metabolism_Homo sapiens_hsa00920	0.84870787
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.84535828
48	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.81605115
49	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.81216378
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.79998859
51	Peroxisome_Homo sapiens_hsa04146	0.77473862
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75840396
53	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.72758054
54	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.70936142
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.70886024
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.70788974
57	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67713396
58	Retinol metabolism_Homo sapiens_hsa00830	0.67224082
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.67080426
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.66170857
61	Sulfur relay system_Homo sapiens_hsa04122	0.64250303
62	Rheumatoid arthritis_Homo sapiens_hsa05323	0.63509788
63	Metabolic pathways_Homo sapiens_hsa01100	0.62517293
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61026060
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56269209
66	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.56258886
67	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54827253
68	Caffeine metabolism_Homo sapiens_hsa00232	0.54428093
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.54159466
70	Non-homologous end-joining_Homo sapiens_hsa03450	0.52551910
71	Nitrogen metabolism_Homo sapiens_hsa00910	0.52424233
72	Collecting duct acid secretion_Homo sapiens_hsa04966	0.51535460
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48712415
74	Taste transduction_Homo sapiens_hsa04742	0.47476540
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47160062
76	Olfactory transduction_Homo sapiens_hsa04740	0.46750692
77	Pyruvate metabolism_Homo sapiens_hsa00620	0.45658208
78	Morphine addiction_Homo sapiens_hsa05032	0.44497794
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.43058803
80	Ether lipid metabolism_Homo sapiens_hsa00565	0.42775260
81	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.41683720
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.39119291
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37559193
84	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.36200096
85	Circadian entrainment_Homo sapiens_hsa04713	0.34578727
86	Antigen processing and presentation_Homo sapiens_hsa04612	0.34438464
87	p53 signaling pathway_Homo sapiens_hsa04115	0.34023818
88	Cell cycle_Homo sapiens_hsa04110	0.29561221
89	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.28855891
90	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.28061750
91	Serotonergic synapse_Homo sapiens_hsa04726	0.27652680
92	Fatty acid degradation_Homo sapiens_hsa00071	0.26331753
93	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.24089116
94	Fat digestion and absorption_Homo sapiens_hsa04975	0.24070041
95	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.22625307
96	Glutathione metabolism_Homo sapiens_hsa00480	0.21460475
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20538009
98	Mineral absorption_Homo sapiens_hsa04978	0.19783945
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.18840486
100	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.18588851

FAM133DP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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