FAM135A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.11560617
2COPI coating of Golgi vesicle (GO:0048205)5.11560617
3COPII vesicle coating (GO:0048208)3.98740828
4macroautophagy (GO:0016236)3.81139216
5endocrine pancreas development (GO:0031018)3.79855586
6regulation of glucokinase activity (GO:0033131)3.65823195
7regulation of hexokinase activity (GO:1903299)3.65823195
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.64522581
9atrial cardiac muscle cell action potential (GO:0086014)3.56058025
10type B pancreatic cell development (GO:0003323)3.50298340
11synapsis (GO:0007129)3.44579002
12glandular epithelial cell differentiation (GO:0002067)3.44016122
13retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.39059008
14exocrine pancreas development (GO:0031017)3.33747481
15cilium or flagellum-dependent cell motility (GO:0001539)3.21507610
16negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18200202
17protein retention in ER lumen (GO:0006621)3.14386572
18peptide hormone processing (GO:0016486)3.11943470
19glandular epithelial cell development (GO:0002068)3.10818595
20positive regulation of hormone biosynthetic process (GO:0046886)3.10683079
21prenylation (GO:0097354)3.05994668
22protein prenylation (GO:0018342)3.05994668
23genitalia morphogenesis (GO:0035112)3.00793626
24L-fucose metabolic process (GO:0042354)2.97590085
25L-fucose catabolic process (GO:0042355)2.97590085
26fucose catabolic process (GO:0019317)2.97590085
27presynaptic membrane assembly (GO:0097105)2.95933512
28activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.94551887
29mitotic sister chromatid cohesion (GO:0007064)2.89047548
30auditory receptor cell differentiation (GO:0042491)2.88019689
31negative regulation of glycogen biosynthetic process (GO:0045719)2.87997622
32chondrocyte development (GO:0002063)2.86642733
33dorsal/ventral axis specification (GO:0009950)2.85242625
34vesicle coating (GO:0006901)2.84282107
35Golgi to endosome transport (GO:0006895)2.82421850
36ER overload response (GO:0006983)2.78289701
37somite rostral/caudal axis specification (GO:0032525)2.77476540
38vitamin transmembrane transport (GO:0035461)2.76456492
39photoreceptor cell maintenance (GO:0045494)2.75503858
40polyol catabolic process (GO:0046174)2.75337078
41regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.75123083
42protein targeting to Golgi (GO:0000042)2.74067064
43regulation of type B pancreatic cell apoptotic process (GO:2000674)2.74045677
44positive regulation of glycoprotein biosynthetic process (GO:0010560)2.72832884
45positive regulation of nuclease activity (GO:0032075)2.72741240
46magnesium ion transport (GO:0015693)2.72502119
47desmosome organization (GO:0002934)2.71802230
48kidney morphogenesis (GO:0060993)2.70017397
49pyrimidine-containing compound transmembrane transport (GO:0072531)2.69265133
50keratinocyte development (GO:0003334)2.68048478
51proline transport (GO:0015824)2.66162818
52columnar/cuboidal epithelial cell development (GO:0002066)2.64682700
53cellular ketone body metabolic process (GO:0046950)2.64338197
54nephron tubule morphogenesis (GO:0072078)2.63212838
55nephron epithelium morphogenesis (GO:0072088)2.63212838
56presynaptic membrane organization (GO:0097090)2.62144117
57negative regulation of glycogen metabolic process (GO:0070874)2.58370991
58insulin secretion (GO:0030073)2.58210685
59DNA double-strand break processing (GO:0000729)2.58094396
60apical protein localization (GO:0045176)2.56153893
61piRNA metabolic process (GO:0034587)2.55965006
62eye photoreceptor cell differentiation (GO:0001754)2.55302923
63photoreceptor cell differentiation (GO:0046530)2.55302923
64establishment of protein localization to Golgi (GO:0072600)2.54169881
65male meiosis (GO:0007140)2.53742476
66negative regulation of translation, ncRNA-mediated (GO:0040033)2.51555272
67regulation of translation, ncRNA-mediated (GO:0045974)2.51555272
68negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51555272
69detection of calcium ion (GO:0005513)2.50645619
70keratinization (GO:0031424)2.49089261
71intestinal absorption (GO:0050892)2.48760389
72negative regulation of DNA-dependent DNA replication (GO:2000104)2.48036277
73neural tube formation (GO:0001841)2.44674247
74cellular response to unfolded protein (GO:0034620)2.44496303
75hair cell differentiation (GO:0035315)2.44120693
76endoplasmic reticulum unfolded protein response (GO:0030968)2.43952292
77ER-nucleus signaling pathway (GO:0006984)2.43663924
78somite development (GO:0061053)2.43213552
79nuclear pore organization (GO:0006999)2.43034779
80retrograde transport, vesicle recycling within Golgi (GO:0000301)2.41360723
81regulation of meiosis I (GO:0060631)2.41043595
82ketone body metabolic process (GO:1902224)2.40432440
83regulation of nuclease activity (GO:0032069)2.40272093
84intra-Golgi vesicle-mediated transport (GO:0006891)2.39942387
85regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.39070906
86synaptonemal complex organization (GO:0070193)2.38402191
87appendage development (GO:0048736)2.37992901
88limb development (GO:0060173)2.37992901
89cilium organization (GO:0044782)2.37734589
90cilium assembly (GO:0042384)2.37381258
91water-soluble vitamin biosynthetic process (GO:0042364)2.36541279
92interkinetic nuclear migration (GO:0022027)2.36018021
93cellular response to topologically incorrect protein (GO:0035967)2.35971074
94chemosensory behavior (GO:0007635)2.34911991
95membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.34901138
96inositol phosphate catabolic process (GO:0071545)2.34813565
97microtubule anchoring (GO:0034453)2.34346966
98epithelial cell fate commitment (GO:0072148)2.34282366
99embryonic axis specification (GO:0000578)2.33913871
100inner ear receptor cell development (GO:0060119)2.33892989
101anterior/posterior axis specification, embryo (GO:0008595)2.33345670
102cellular response to vitamin D (GO:0071305)2.33152184
103kinetochore organization (GO:0051383)2.32686991
104body morphogenesis (GO:0010171)2.32377451
105protein maturation by protein folding (GO:0022417)2.32300615
106asymmetric protein localization (GO:0008105)2.29787580
107fusion of sperm to egg plasma membrane (GO:0007342)2.29644813
108cytoplasmic mRNA processing body assembly (GO:0033962)2.29399357
109kinetochore assembly (GO:0051382)2.29188751
110polarized epithelial cell differentiation (GO:0030859)2.29067541
111ncRNA catabolic process (GO:0034661)2.28967475
112synaptonemal complex assembly (GO:0007130)2.27193444
113regulation of mitotic spindle checkpoint (GO:1903504)2.26198383
114regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.26198383
115reciprocal meiotic recombination (GO:0007131)2.26194308
116reciprocal DNA recombination (GO:0035825)2.26194308
117regulation of non-canonical Wnt signaling pathway (GO:2000050)2.25594430
118UDP-N-acetylglucosamine metabolic process (GO:0006047)2.24989317
119indole-containing compound catabolic process (GO:0042436)2.24577926
120indolalkylamine catabolic process (GO:0046218)2.24577926
121tryptophan catabolic process (GO:0006569)2.24577926
122positive regulation of glycolytic process (GO:0045821)2.24416831
123G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.23574731
124dopaminergic neuron differentiation (GO:0071542)2.23330588
125centriole replication (GO:0007099)2.23074482
126RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.22821341
127stress granule assembly (GO:0034063)2.22757795
128protein localization to Golgi apparatus (GO:0034067)2.22387624
129positive regulation of histone H3-K4 methylation (GO:0051571)2.22011777
130intestinal cholesterol absorption (GO:0030299)2.21934899
131lactate metabolic process (GO:0006089)2.21487812
132regulation of mesoderm development (GO:2000380)2.20207539
133astrocyte differentiation (GO:0048708)2.19968029
134acrosome assembly (GO:0001675)2.19677798
135interleukin-6-mediated signaling pathway (GO:0070102)2.19577192
136regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.19576002
137oocyte development (GO:0048599)2.19425872
138nonmotile primary cilium assembly (GO:0035058)2.19295095
139ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.18410698
140intraciliary transport (GO:0042073)2.18387539
141regulation of male gonad development (GO:2000018)2.18367247
142peptidyl-cysteine modification (GO:0018198)2.18238773
143replication fork processing (GO:0031297)2.18222227
144insulin-like growth factor receptor signaling pathway (GO:0048009)2.18046547
145embryonic pattern specification (GO:0009880)2.17883038
146embryonic foregut morphogenesis (GO:0048617)2.17491159
147regulation of Rac protein signal transduction (GO:0035020)2.17350917
148protein localization to kinetochore (GO:0034501)2.16472412
149prostate gland growth (GO:0060736)2.16182764
150regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.16164058
151regulation of cardioblast proliferation (GO:0003264)2.16012529
152regulation of secondary heart field cardioblast proliferation (GO:0003266)2.16012529
153calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.15951970
154embryonic body morphogenesis (GO:0010172)2.15899890
155Sertoli cell development (GO:0060009)2.15186725
156smoothened signaling pathway (GO:0007224)2.14975273
157convergent extension (GO:0060026)2.14722345
158endocardial cushion morphogenesis (GO:0003203)2.14670834
159renal tubule morphogenesis (GO:0061333)2.14663096
160negative regulation of hormone metabolic process (GO:0032351)2.13636445
161negative regulation of hormone biosynthetic process (GO:0032353)2.13636445
162Golgi organization (GO:0007030)2.13508297
163reflex (GO:0060004)2.13452992
164coronary vasculature morphogenesis (GO:0060977)2.13291055
165protein localization to cilium (GO:0061512)2.13041095
166pancreas development (GO:0031016)2.12295511
167C4-dicarboxylate transport (GO:0015740)2.12254233
168bundle of His cell to Purkinje myocyte communication (GO:0086069)2.10835764
169rRNA catabolic process (GO:0016075)2.10721513
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.10614729
171regulation of centriole replication (GO:0046599)2.10526356
172positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.10348591
173embryonic retina morphogenesis in camera-type eye (GO:0060059)2.09819231
174regulation of heart rate by cardiac conduction (GO:0086091)2.09646643
175signal transduction involved in regulation of gene expression (GO:0023019)2.09635843
176recombinational repair (GO:0000725)2.09622516
1774-hydroxyproline metabolic process (GO:0019471)2.09545069
178negative regulation of keratinocyte proliferation (GO:0010839)2.09270974
179positive regulation of hormone metabolic process (GO:0032352)2.09228727
180ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.09221412
181regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.08357984
182intestinal epithelial cell development (GO:0060576)2.07898989
183endoplasmic reticulum organization (GO:0007029)2.06560488
184positive regulation of insulin secretion (GO:0032024)2.06550127
185membrane repolarization during action potential (GO:0086011)2.05940801
186peptide hormone secretion (GO:0030072)2.04357511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.96079774
2IGF1R_20145208_ChIP-Seq_DFB_Human2.67416247
3FUS_26573619_Chip-Seq_HEK293_Human2.62769000
4EZH2_22144423_ChIP-Seq_EOC_Human2.61684202
5TAF15_26573619_Chip-Seq_HEK293_Human2.41725102
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27814855
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.23108225
8EWS_26573619_Chip-Seq_HEK293_Human2.18048710
9* FLI1_27457419_Chip-Seq_LIVER_Mouse2.14464768
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.01365451
11TP63_17297297_ChIP-ChIP_HaCaT_Human1.96072675
12ZNF217_24962896_ChIP-Seq_MCF-7_Human1.92428598
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85394715
14GBX2_23144817_ChIP-Seq_PC3_Human1.79977981
15TRIM28_21343339_ChIP-Seq_HEK293_Human1.78095396
16AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78057235
17PIAS1_25552417_ChIP-Seq_VCAP_Human1.73602475
18* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72591680
19ZNF274_21170338_ChIP-Seq_K562_Hela1.70834229
20UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.61390703
21EP300_21415370_ChIP-Seq_HL-1_Mouse1.56214340
22RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54885722
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.54825372
24BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53374731
25HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52023759
26ER_23166858_ChIP-Seq_MCF-7_Human1.51954774
27* EZH2_27294783_Chip-Seq_NPCs_Mouse1.51093804
28AR_25329375_ChIP-Seq_VCAP_Human1.50191851
29BCAT_22108803_ChIP-Seq_LS180_Human1.49647447
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47944225
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47380136
32CBP_20019798_ChIP-Seq_JUKART_Human1.47380136
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46782442
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45873365
35SMAD4_21799915_ChIP-Seq_A2780_Human1.44818449
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.42086047
37* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41720850
38* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.41405594
39STAT3_23295773_ChIP-Seq_U87_Human1.38890966
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35683434
41EZH2_27304074_Chip-Seq_ESCs_Mouse1.35458247
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33592812
43* RUNX2_22187159_ChIP-Seq_PCA_Human1.32933494
44SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32853252
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31980241
46* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31730773
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.31729796
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31204605
49* CDX2_22108803_ChIP-Seq_LS180_Human1.30610717
50* NFE2_27457419_Chip-Seq_LIVER_Mouse1.30178354
51VDR_22108803_ChIP-Seq_LS180_Human1.29526249
52* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28782705
53TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.28509996
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26212726
55* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25732857
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.25427992
57PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25010142
58SMAD3_21741376_ChIP-Seq_EPCs_Human1.24425328
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24380196
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24011762
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.23795568
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23287861
63* P53_22387025_ChIP-Seq_ESCs_Mouse1.23220623
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.23185936
65* E2F1_18555785_Chip-Seq_ESCs_Mouse1.22488447
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22350099
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22245575
68* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21786132
69NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19660353
70LXR_22158963_ChIP-Seq_LIVER_Mouse1.18805835
71SOX2_21211035_ChIP-Seq_LN229_Gbm1.18473033
72YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17900421
73* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.17523824
74ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17297843
75ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17156180
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.16531494
77SOX2_19829295_ChIP-Seq_ESCs_Human1.16059549
78NANOG_19829295_ChIP-Seq_ESCs_Human1.16059549
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.15739565
80MTF2_20144788_ChIP-Seq_MESCs_Mouse1.15399752
81* CMYC_18555785_Chip-Seq_ESCs_Mouse1.15352305
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14186785
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13993052
84* EZH2_27294783_Chip-Seq_ESCs_Mouse1.13927254
85AHR_22903824_ChIP-Seq_MCF-7_Human1.13442849
86* STAT3_18555785_Chip-Seq_ESCs_Mouse1.12808000
87TAL1_26923725_Chip-Seq_HPCs_Mouse1.12618004
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11967902
89FLI1_21867929_ChIP-Seq_TH2_Mouse1.11288982
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.11189819
91RNF2_27304074_Chip-Seq_NSC_Mouse1.10117898
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.09953458
93JARID2_20075857_ChIP-Seq_MESCs_Mouse1.09752499
94STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09428880
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09298408
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.09055282
97SMAD4_21741376_ChIP-Seq_EPCs_Human1.08590750
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.08540585
99FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08371015
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08198556
101FOXM1_26456572_ChIP-Seq_MCF-7_Human1.07765856
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07751260
103* CRX_20693478_ChIP-Seq_RETINA_Mouse1.07539161
104FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.07027650
105EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06941470
106RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06941470
107EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06893998
108* P300_18555785_Chip-Seq_ESCs_Mouse1.06756057
109SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.06537912
110TCF4_23295773_ChIP-Seq_U87_Human1.06373470
111RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05901073
112AR_19668381_ChIP-Seq_PC3_Human1.05710409
113CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05548547
114ELK1_19687146_ChIP-ChIP_HELA_Human1.05486544
115BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05151185
116* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05112121
117BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04895729
118* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04868622
119* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04769245
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.04580763
121TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04453220
122* SOX2_18555785_Chip-Seq_ESCs_Mouse1.04140593
123REST_21632747_ChIP-Seq_MESCs_Mouse1.03792243
124* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03158352
125CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03047423
126JUN_21703547_ChIP-Seq_K562_Human1.02858980
127CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02756160
128WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02657327
129EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01961793
130* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01799008
131HTT_18923047_ChIP-ChIP_STHdh_Human1.01036720
132* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00974021
133* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00825730
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00454134
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00454134
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00336448
137DROSHA_22980978_ChIP-Seq_HELA_Human0.99820147
138* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99764048
139P300_19829295_ChIP-Seq_ESCs_Human0.99720100
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.99686604
141* OCT4_18555785_Chip-Seq_ESCs_Mouse0.99599303
142* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98753584
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.97185811
144PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.96953810
145TCF4_22108803_ChIP-Seq_LS180_Human0.96863234
146TBX3_20139965_ChIP-Seq_MESCs_Mouse0.96757967
147TP53_18474530_ChIP-ChIP_U2OS_Human0.96584141
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96345945
149* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.95849125
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95744997
151ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95521372
152TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95370109
153LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94276876
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93884853
155NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93884853

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo3.34311660
2MP0003283_abnormal_digestive_organ3.15375784
3MP0008057_abnormal_DNA_replication2.74903942
4MP0008877_abnormal_DNA_methylation2.51134501
5MP0003195_calcinosis2.47434081
6MP0002877_abnormal_melanocyte_morpholog2.36090583
7MP0000013_abnormal_adipose_tissue2.31357263
8MP0002909_abnormal_adrenal_gland2.24764450
9MP0002102_abnormal_ear_morphology2.24034609
10MP0004043_abnormal_pH_regulation2.09094712
11MP0002234_abnormal_pharynx_morphology2.03773226
12MP0000569_abnormal_digit_pigmentation2.00466485
13MP0000678_abnormal_parathyroid_gland1.98172389
14MP0002139_abnormal_hepatobiliary_system1.97471538
15MP0010234_abnormal_vibrissa_follicle1.96597631
16MP0001944_abnormal_pancreas_morphology1.93992520
17MP0005187_abnormal_penis_morphology1.90103034
18MP0001299_abnormal_eye_distance/1.87731762
19MP0002896_abnormal_bone_mineralization1.86615037
20MP0005551_abnormal_eye_electrophysiolog1.85115120
21MP0000537_abnormal_urethra_morphology1.77921572
22MP0010352_gastrointestinal_tract_polyps1.75105240
23MP0005220_abnormal_exocrine_pancreas1.73421826
24MP0003122_maternal_imprinting1.70255547
25MP0004264_abnormal_extraembryonic_tissu1.65242713
26MP0000462_abnormal_digestive_system1.64747503
27MP0003718_maternal_effect1.57608423
28MP0003252_abnormal_bile_duct1.57347354
29MP0003119_abnormal_digestive_system1.56486813
30MP0004215_abnormal_myocardial_fiber1.54720427
31MP0005248_abnormal_Harderian_gland1.52699978
32MP0000566_synostosis1.52020698
33MP0000579_abnormal_nail_morphology1.50863157
34MP0006072_abnormal_retinal_apoptosis1.49931094
35MP0002693_abnormal_pancreas_physiology1.48498344
36MP0002837_dystrophic_cardiac_calcinosis1.46549655
37MP0003941_abnormal_skin_development1.45517594
38MP0001984_abnormal_olfaction1.44365963
39MP0003890_abnormal_embryonic-extraembry1.43612095
40MP0001485_abnormal_pinna_reflex1.41913695
41MP0009046_muscle_twitch1.40336791
42MP0005174_abnormal_tail_pigmentation1.38097204
43MP0005379_endocrine/exocrine_gland_phen1.37489817
44MP0005365_abnormal_bile_salt1.35827591
45MP0001293_anophthalmia1.33884352
46MP0005257_abnormal_intraocular_pressure1.33871797
47MP0003705_abnormal_hypodermis_morpholog1.33611102
48MP0005645_abnormal_hypothalamus_physiol1.33434674
49MP0000003_abnormal_adipose_tissue1.32579275
50MP0005410_abnormal_fertilization1.31137963
51MP0004270_analgesia1.29217058
52MP0008058_abnormal_DNA_repair1.29011715
53MP0006292_abnormal_olfactory_placode1.25119764
54MP0000647_abnormal_sebaceous_gland1.24583636
55MP0000427_abnormal_hair_cycle1.24420705
56MP0003183_abnormal_peptide_metabolism1.20958270
57MP0001188_hyperpigmentation1.20880571
58MP0002163_abnormal_gland_morphology1.19376357
59MP0009384_cardiac_valve_regurgitation1.18567132
60MP0002095_abnormal_skin_pigmentation1.18512749
61MP0010386_abnormal_urinary_bladder1.16843446
62MP0001486_abnormal_startle_reflex1.16765380
63MP0003868_abnormal_feces_composition1.15677503
64MP0003937_abnormal_limbs/digits/tail_de1.14131630
65MP0003136_yellow_coat_color1.14125599
66MP0002638_abnormal_pupillary_reflex1.13951610
67MP0009053_abnormal_anal_canal1.12105930
68MP0002272_abnormal_nervous_system1.10639448
69MP0002098_abnormal_vibrissa_morphology1.10222116
70MP0002160_abnormal_reproductive_system1.09995464
71MP0001501_abnormal_sleep_pattern1.09477222
72MP0003935_abnormal_craniofacial_develop1.08604462
73MP0000631_abnormal_neuroendocrine_gland1.06259640
74MP0003942_abnormal_urinary_system1.06123999
75MP0000428_abnormal_craniofacial_morphol1.05469700
76MP0010678_abnormal_skin_adnexa1.05452965
77MP0000762_abnormal_tongue_morphology1.05302811
78MP0009250_abnormal_appendicular_skeleto1.05228950
79MP0003755_abnormal_palate_morphology1.04744570
80MP0002233_abnormal_nose_morphology1.03695056
81MP0001270_distended_abdomen1.03491759
82MP0002090_abnormal_vision1.03266148
83MP0003880_abnormal_central_pattern1.02838730
84MP0005275_abnormal_skin_tensile1.02591897
85MP0000778_abnormal_nervous_system1.02334887
86MP0003011_delayed_dark_adaptation1.01538034
87MP0001666_abnormal_nutrient_absorption1.01069237
88MP0000163_abnormal_cartilage_morphology1.00639834
89MP0005085_abnormal_gallbladder_physiolo0.99738687
90MP0003123_paternal_imprinting0.99147508
91MP0006276_abnormal_autonomic_nervous0.99106685
92MP0004147_increased_porphyrin_level0.98927561
93MP0009703_decreased_birth_body0.98615402
94MP0009672_abnormal_birth_weight0.98302610
95MP0002116_abnormal_craniofacial_bone0.97651702
96MP0001324_abnormal_eye_pigmentation0.97154732
97MP0000534_abnormal_ureter_morphology0.96354760
98MP0002282_abnormal_trachea_morphology0.95791786
99MP0004924_abnormal_behavior0.95628673
100MP0005386_behavior/neurological_phenoty0.95628673
101MP0002177_abnormal_outer_ear0.95522058
102MP0000516_abnormal_urinary_system0.94380164
103MP0005367_renal/urinary_system_phenotyp0.94380164
104MP0004019_abnormal_vitamin_homeostasis0.94328802
105MP0005646_abnormal_pituitary_gland0.94240433
106MP0005503_abnormal_tendon_morphology0.94053752
107MP0002078_abnormal_glucose_homeostasis0.93704788
108MP0003121_genomic_imprinting0.93685596
109MP0002938_white_spotting0.93556075
110MP0010094_abnormal_chromosome_stability0.93165755
111MP0002557_abnormal_social/conspecific_i0.93058758
112MP0004885_abnormal_endolymph0.92903619
113MP0002249_abnormal_larynx_morphology0.92376526
114MP0000049_abnormal_middle_ear0.91915029
115MP0002653_abnormal_ependyma_morphology0.90473606
116MP0010030_abnormal_orbit_morphology0.90455818
117MP0002108_abnormal_muscle_morphology0.90409521
118MP0005076_abnormal_cell_differentiation0.88891235
119MP0003787_abnormal_imprinting0.88432666
120MP0003878_abnormal_ear_physiology0.88396669
121MP0005377_hearing/vestibular/ear_phenot0.88396669
122MP0005391_vision/eye_phenotype0.88334694
123MP0004272_abnormal_basement_membrane0.88084281
124MP0009745_abnormal_behavioral_response0.87363416
125MP0003693_abnormal_embryo_hatching0.87000268
126MP0001529_abnormal_vocalization0.86613115
127MP0000432_abnormal_head_morphology0.86588143
128MP0003045_fibrosis0.85410091
129MP0002928_abnormal_bile_duct0.85328095
130MP0001286_abnormal_eye_development0.84940766
131MP0003385_abnormal_body_wall0.84562080
132MP0002009_preneoplasia0.84194642
133MP0009697_abnormal_copulation0.83757266
134MP0001346_abnormal_lacrimal_gland0.82740579
135MP0002796_impaired_skin_barrier0.82291418
136MP0003115_abnormal_respiratory_system0.81942108
137MP0003567_abnormal_fetal_cardiomyocyte0.81346154
138MP0005332_abnormal_amino_acid0.81178563
139MP0002229_neurodegeneration0.80853825
140MP0008961_abnormal_basal_metabolism0.80531155
141MP0004134_abnormal_chest_morphology0.80031028
142MP0005195_abnormal_posterior_eye0.79998175
143MP0000372_irregular_coat_pigmentation0.79687980
144MP0000613_abnormal_salivary_gland0.79560352
145MP0004085_abnormal_heartbeat0.79496192
146MP0000538_abnormal_urinary_bladder0.79362504
147MP0002084_abnormal_developmental_patter0.78147040
148MP0000467_abnormal_esophagus_morphology0.77597106
149MP0001765_abnormal_ion_homeostasis0.77404768
150MP0000383_abnormal_hair_follicle0.77273485
151MP0001929_abnormal_gametogenesis0.77236136
152MP0002115_abnormal_skeleton_extremities0.77224794
153MP0005508_abnormal_skeleton_morphology0.77044704
154MP0005253_abnormal_eye_physiology0.76334213
155MP0002822_catalepsy0.74877546
156MP0005075_abnormal_melanosome_morpholog0.74393984
157MP0005389_reproductive_system_phenotype0.74217150
158MP0002735_abnormal_chemical_nociception0.71268010

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)4.35090887
2Hypoglycemic seizures (HP:0002173)3.85078317
3Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.72927196
4Hypoplastic ischia (HP:0003175)3.57379720
5Symptomatic seizures (HP:0011145)3.54119486
6Hyperglycemia (HP:0003074)3.54075071
7Abnormality of the ischium (HP:0003174)3.40750050
8Epiphyseal dysplasia (HP:0002656)3.39538788
9Vitreoretinal degeneration (HP:0000655)3.23825027
10Hypoglycemic coma (HP:0001325)3.15839046
11Hypoplastic labia majora (HP:0000059)3.04626208
12Nephronophthisis (HP:0000090)3.01214776
13Insulin-resistant diabetes mellitus (HP:0000831)2.99634612
14Intestinal atresia (HP:0011100)2.75771215
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75363902
16Abnormality of the renal cortex (HP:0011035)2.71890117
17Abnormality of the renal medulla (HP:0100957)2.71809793
18Abnormality of the labia majora (HP:0012881)2.70604073
19Abnormal pancreas size (HP:0012094)2.64739702
20Pancreatic cysts (HP:0001737)2.63642597
21Pancreatic fibrosis (HP:0100732)2.63034210
22True hermaphroditism (HP:0010459)2.62033109
23Hepatoblastoma (HP:0002884)2.57375229
24Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.55961944
25Abnormality of midbrain morphology (HP:0002418)2.49379532
26Molar tooth sign on MRI (HP:0002419)2.49379532
27Volvulus (HP:0002580)2.45911794
28Chronic hepatic failure (HP:0100626)2.45123348
29Renal cortical cysts (HP:0000803)2.42693787
30Medial flaring of the eyebrow (HP:0010747)2.39035340
31Gaze-evoked nystagmus (HP:0000640)2.38182413
32Hypomagnesemia (HP:0002917)2.36154102
33Pancreatic islet-cell hyperplasia (HP:0004510)2.33526726
34Neoplasm of the adrenal cortex (HP:0100641)2.33108062
35Ketoacidosis (HP:0001993)2.27540932
36Abnormality of endocrine pancreas physiology (HP:0012093)2.25474058
37Abnormality of the pancreatic islet cells (HP:0006476)2.25474058
38Abnormality of vitamin B metabolism (HP:0004340)2.23652853
39Abnormality of calcium-phosphate metabolism (HP:0100530)2.21538830
40Labial hypoplasia (HP:0000066)2.21418003
41Chronic bronchitis (HP:0004469)2.19988095
42Papillary thyroid carcinoma (HP:0002895)2.18074128
43Genital tract atresia (HP:0001827)2.17640336
44Congenital primary aphakia (HP:0007707)2.16390572
45Tubulointerstitial nephritis (HP:0001970)2.15979204
46Aplasia/Hypoplasia of the tibia (HP:0005772)2.15102216
47Absent eyebrow (HP:0002223)2.14229168
48Gait imbalance (HP:0002141)2.13190580
49Vaginal atresia (HP:0000148)2.11593545
50Metaphyseal cupping (HP:0003021)2.10639368
51Fair hair (HP:0002286)2.10173548
52Protuberant abdomen (HP:0001538)2.08815193
53Gastrointestinal atresia (HP:0002589)2.06927072
54Retinal atrophy (HP:0001105)2.05932774
55Palmar hyperkeratosis (HP:0010765)2.05514248
56Absent/shortened dynein arms (HP:0200106)2.05105617
57Dynein arm defect of respiratory motile cilia (HP:0012255)2.05105617
58Late onset (HP:0003584)2.04284495
59Broad-based gait (HP:0002136)2.02544024
60Missing ribs (HP:0000921)2.00593339
61Furrowed tongue (HP:0000221)2.00439723
62Cupped ribs (HP:0000887)2.00006077
63Intrahepatic cholestasis (HP:0001406)1.99066042
64Hyperventilation (HP:0002883)1.96030443
65Hypothermia (HP:0002045)1.96029702
66Progressive inability to walk (HP:0002505)1.95626280
67Conjugated hyperbilirubinemia (HP:0002908)1.94345473
68Colon cancer (HP:0003003)1.94075011
69Aqueductal stenosis (HP:0002410)1.93101932
70Cerebellar dysplasia (HP:0007033)1.92651175
71Agitation (HP:0000713)1.91389187
72Nephrogenic diabetes insipidus (HP:0009806)1.91175285
73Abnormal biliary tract physiology (HP:0012439)1.91038760
74Bile duct proliferation (HP:0001408)1.91038760
75Abnormality of macular pigmentation (HP:0008002)1.89282287
76Right ventricular cardiomyopathy (HP:0011663)1.89140411
77Methylmalonic acidemia (HP:0002912)1.89086835
78Bronchomalacia (HP:0002780)1.88968876
79Abnormality of the labia minora (HP:0012880)1.88546318
80Exostoses (HP:0100777)1.88058385
81Palmoplantar hyperkeratosis (HP:0000972)1.87807301
82Tubular atrophy (HP:0000092)1.87062570
83Macroorchidism (HP:0000053)1.86860210
84Widely spaced teeth (HP:0000687)1.86121425
85Flat capital femoral epiphysis (HP:0003370)1.85537045
86Hypoplastic female external genitalia (HP:0012815)1.85324669
87Flat acetabular roof (HP:0003180)1.84211877
88Irregular epiphyses (HP:0010582)1.83654209
89Epidermoid cyst (HP:0200040)1.83571820
90Abnormal sex determination (HP:0012244)1.81482968
91Sex reversal (HP:0012245)1.81482968
92Poor coordination (HP:0002370)1.80492290
93Unilateral renal agenesis (HP:0000122)1.79172314
94Protruding tongue (HP:0010808)1.79164961
9511 pairs of ribs (HP:0000878)1.78797740
96Hyperphosphatemia (HP:0002905)1.78356861
97Turricephaly (HP:0000262)1.77345891
98Large for gestational age (HP:0001520)1.77329656
99Abnormality of secondary sexual hair (HP:0009888)1.76679852
100Abnormality of the axillary hair (HP:0100134)1.76679852
101Congenital glaucoma (HP:0001087)1.75935987
102Abnormality of the vitamin B12 metabolism (HP:0004341)1.75502487
103Congenital stationary night blindness (HP:0007642)1.74710961
104Thoracolumbar scoliosis (HP:0002944)1.74394134
105Abnormal respiratory motile cilium physiology (HP:0012261)1.74280792
106Abnormality of the intrinsic pathway (HP:0010989)1.74107843
107Neonatal short-limb short stature (HP:0008921)1.73982287
108Biliary tract neoplasm (HP:0100574)1.73829763
109Mildly elevated creatine phosphokinase (HP:0008180)1.73689070
110Short tibia (HP:0005736)1.73501493
111Abdominal distention (HP:0003270)1.73269894
112Fibular hypoplasia (HP:0003038)1.72936103
113Febrile seizures (HP:0002373)1.72918536
114Thyroid carcinoma (HP:0002890)1.72635108
115Bell-shaped thorax (HP:0001591)1.72202836
116Abolished electroretinogram (ERG) (HP:0000550)1.72024527
117Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.71358093
118Glioma (HP:0009733)1.69944256
119Esophageal atresia (HP:0002032)1.69395470
120Absent eyelashes (HP:0000561)1.69229380
121Hyperglycinuria (HP:0003108)1.68202726
122Abnormality of the pubic bones (HP:0003172)1.67620812
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.67328592
124Dialeptic seizures (HP:0011146)1.66889834
125Hemiparesis (HP:0001269)1.66037967
126Supernumerary spleens (HP:0009799)1.65774199
127Congenital malformation of the right heart (HP:0011723)1.65729000
128Double outlet right ventricle (HP:0001719)1.65729000
129Delayed epiphyseal ossification (HP:0002663)1.65620568
130Abnormal drinking behavior (HP:0030082)1.65422010
131Polydipsia (HP:0001959)1.65422010
132Abnormal tarsal ossification (HP:0008369)1.65208377
133Drooling (HP:0002307)1.63634156
134Median cleft lip (HP:0000161)1.63627865
135Thin ribs (HP:0000883)1.63546385
136Abnormality of vitamin metabolism (HP:0100508)1.63200943
137Optic nerve hypoplasia (HP:0000609)1.63193743
138Cutaneous finger syndactyly (HP:0010554)1.62471021
139Broad thumb (HP:0011304)1.61684386
140Absent hair (HP:0002298)1.61502626
141Bifid tongue (HP:0010297)1.61463393
142Nephroblastoma (Wilms tumor) (HP:0002667)1.58676608
143Decreased circulating renin level (HP:0003351)1.58652302
144Curly hair (HP:0002212)1.58413233
145Hyperkalemia (HP:0002153)1.57763904
146Mixed hearing impairment (HP:0000410)1.57180432
147EEG with generalized epileptiform discharges (HP:0011198)1.56998765
148Inability to walk (HP:0002540)1.56939312
149Vertebral clefting (HP:0008428)1.56558252
150Rhizomelia (HP:0008905)1.55500932
151Hypokalemia (HP:0002900)1.55049892
152Buphthalmos (HP:0000557)1.54081359
153Hypsarrhythmia (HP:0002521)1.53662158
154Insulin resistance (HP:0000855)1.53333216
155Congenital sensorineural hearing impairment (HP:0008527)1.52757701
156Osteoarthritis (HP:0002758)1.52223817
157Rhinitis (HP:0012384)1.49929937
158Hypoplasia of dental enamel (HP:0006297)1.49707117
159Cystic liver disease (HP:0006706)1.49167765
160Epileptiform EEG discharges (HP:0011182)1.47900022
161Abnormality of potassium homeostasis (HP:0011042)1.46456866
162Osteomalacia (HP:0002749)1.44646765
163Abnormal biliary tract morphology (HP:0012440)1.41628851
164Anteriorly placed anus (HP:0001545)1.41056522
165Abnormal foot bone ossification (HP:0010675)1.40810400
166Broad phalanx (HP:0006009)1.40599086
167Abnormality of the right ventricle (HP:0001707)1.40188238
168Occipital encephalocele (HP:0002085)1.38774533
169Cutaneous syndactyly (HP:0012725)1.38062827
170Abnormality of the labia (HP:0000058)1.37966879
171Metaphyseal irregularity (HP:0003025)1.37684340
172Micromelia (HP:0002983)1.36805616
173Abnormal vertebral ossification (HP:0100569)1.36797104
174Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.36367840
175Enlarged epiphyses (HP:0010580)1.35337973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.80118790
2LATS13.15643938
3PRKD33.02154867
4ACVR1B2.89040295
5MAP3K22.59933019
6PASK2.57587545
7WNK42.45070548
8ZAK2.43716402
9MAP4K22.41182706
10FRK2.36058490
11EIF2AK32.30868693
12MKNK22.23728825
13MAPK152.18085944
14TNIK2.13247270
15CASK2.09370128
16PDGFRA2.00944898
17WNK31.94850296
18TAOK31.94453636
19MST41.80765813
20DDR21.78182911
21PDK31.77884344
22PDK41.77884344
23MET1.76803704
24STK38L1.73322299
25FER1.63985168
26FGFR21.62218687
27EPHB21.61817467
28MKNK11.58511647
29ERBB31.57124142
30BCR1.49418971
31WNK11.48552142
32CDC42BPA1.44205247
33NTRK31.41694075
34PAK31.40226498
35AKT31.37925245
36HIPK21.32754955
37PINK11.30257840
38PLK31.27335412
39PTK61.26886280
40MST1R1.25352790
41TRIM281.23411980
42PLK41.19582875
43PTK21.19329231
44CAMK1G1.18404599
45BRD41.16842483
46TSSK61.16293436
47TRIB31.14719411
48TTK1.12574797
49NUAK11.11936596
50OXSR11.07481782
51GRK11.07353189
52NLK1.07095592
53WEE11.04900821
54CDK121.04771557
55MARK11.04513911
56NEK11.02652566
57TGFBR11.02140683
58EPHA21.02057717
59EPHA30.99430528
60MAPK130.99367481
61PLK20.98131569
62ICK0.98113988
63DYRK1B0.97978288
64STK160.97379213
65FGFR10.95951016
66UHMK10.94895131
67ERBB40.94721567
68STK30.94527362
69SIK10.93081478
70SRPK10.92278224
71RET0.91909398
72PNCK0.89239835
73ADRBK20.85950473
74PDK20.85459724
75NTRK10.84149156
76CSNK1G30.83429649
77PDGFRB0.82694731
78MTOR0.80563645
79TYRO30.79374873
80CDC70.78817310
81PRKAA10.78140999
82CSNK1A1L0.77927226
83MAP3K30.75414860
84PBK0.75110926
85SGK4940.74934281
86SGK2230.74934281
87STK390.74641268
88CAMK1D0.74335696
89STK240.74247411
90ERBB20.73783499
91RIPK10.72469657
92MAP2K70.71220255
93PIK3CA0.70123278
94KSR10.69716224
95TRPM70.69591043
96SCYL20.69211681
97MAP3K40.68035369
98TESK10.67766365
99EIF2AK20.65914761
100SGK20.65088998
101ATM0.64287587
102VRK10.63539951
103DAPK20.63515075
104PLK10.63298132
105MAP3K10.63036097
106CSNK1G20.62429832
107PRKCG0.62389899
108EEF2K0.62098589
109ERN10.60333208
110NEK60.58483017
111PRKCH0.58191678
112PRKAA20.56643888
113SGK30.55302675
114FGFR30.54857038
115FGFR40.52461319
116PRKCE0.51502332
117PTK2B0.51412299
118BRSK20.51361497
119CAMK2D0.50896604
120CDK30.50851502
121GSK3A0.49272053
122STK380.48728913
123MELK0.48367393
124KSR20.47588694
125DYRK1A0.46498471
126MAPKAPK50.46413795
127YES10.46357747
128IRAK10.46309070
129CDK90.45274444
130PHKG10.44923872
131PHKG20.44923872
132LMTK20.44769821
133NEK20.44568856
134MAP2K10.43492790
135BMPR1B0.43286411
136CSNK1D0.42498812
137OBSCN0.41420934
138SGK10.40863938
139PRKD10.39042805
140CSNK1G10.38531896
141CSNK1E0.38223635
142MAPK100.38209811
143RPS6KB10.37672014
144DYRK30.37329322
145CAMK2A0.37113871
146FLT30.36460970
147ROCK10.36188839
148CSNK1A10.35794021
149MAP2K20.35512213
150PRKACB0.32900902
151EPHA40.31278838
152CCNB10.29839188
153MAP2K40.28077966
154CHEK20.27441070

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.76626341
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.71828009
3Sulfur metabolism_Homo sapiens_hsa009202.52223062
4Insulin secretion_Homo sapiens_hsa049112.43018190
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.13837821
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.04198847
7Basal transcription factors_Homo sapiens_hsa030221.88453329
8Ether lipid metabolism_Homo sapiens_hsa005651.84152491
9Nitrogen metabolism_Homo sapiens_hsa009101.80074307
10Vitamin digestion and absorption_Homo sapiens_hsa049771.79368550
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.76834490
12Non-homologous end-joining_Homo sapiens_hsa034501.75488265
13Selenocompound metabolism_Homo sapiens_hsa004501.70245132
14Protein export_Homo sapiens_hsa030601.65867610
15Type II diabetes mellitus_Homo sapiens_hsa049301.58919875
16Nicotine addiction_Homo sapiens_hsa050331.55295340
17Homologous recombination_Homo sapiens_hsa034401.53105091
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.46148937
19Dorso-ventral axis formation_Homo sapiens_hsa043201.45823949
20Cocaine addiction_Homo sapiens_hsa050301.42014459
21Glucagon signaling pathway_Homo sapiens_hsa049221.37688058
22Protein digestion and absorption_Homo sapiens_hsa049741.35511189
23Amphetamine addiction_Homo sapiens_hsa050311.34778790
24Vitamin B6 metabolism_Homo sapiens_hsa007501.33516848
25Circadian rhythm_Homo sapiens_hsa047101.23904702
26Hedgehog signaling pathway_Homo sapiens_hsa043401.23331472
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23101997
28RNA degradation_Homo sapiens_hsa030181.21823036
29Fanconi anemia pathway_Homo sapiens_hsa034601.20496241
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.19590334
31Fat digestion and absorption_Homo sapiens_hsa049751.19169867
32Peroxisome_Homo sapiens_hsa041461.19157783
33Basal cell carcinoma_Homo sapiens_hsa052171.16879209
34Pancreatic secretion_Homo sapiens_hsa049721.14136585
35Lysine degradation_Homo sapiens_hsa003101.11503075
36Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11247407
37Retinol metabolism_Homo sapiens_hsa008301.09937183
38Bile secretion_Homo sapiens_hsa049761.09604926
39Tryptophan metabolism_Homo sapiens_hsa003801.08591719
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.07667216
41Arginine biosynthesis_Homo sapiens_hsa002201.06614768
42Thyroid hormone synthesis_Homo sapiens_hsa049181.06096459
43Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03973760
44Oocyte meiosis_Homo sapiens_hsa041141.02806898
45Butanoate metabolism_Homo sapiens_hsa006501.01756066
46Circadian entrainment_Homo sapiens_hsa047131.01554513
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99281805
48Phototransduction_Homo sapiens_hsa047440.98185966
49Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97965521
50Regulation of autophagy_Homo sapiens_hsa041400.97026430
51ABC transporters_Homo sapiens_hsa020100.96000459
52RNA transport_Homo sapiens_hsa030130.95874499
53Adherens junction_Homo sapiens_hsa045200.95228706
54Dopaminergic synapse_Homo sapiens_hsa047280.94790436
55Caffeine metabolism_Homo sapiens_hsa002320.94119712
56Long-term potentiation_Homo sapiens_hsa047200.93863607
57Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93766925
58Melanogenesis_Homo sapiens_hsa049160.93089910
59Insulin resistance_Homo sapiens_hsa049310.92637228
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91944722
61Vibrio cholerae infection_Homo sapiens_hsa051100.91211293
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88882814
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88203665
64Estrogen signaling pathway_Homo sapiens_hsa049150.87789595
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87115500
66Hippo signaling pathway_Homo sapiens_hsa043900.87047567
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.86876356
68One carbon pool by folate_Homo sapiens_hsa006700.86816544
69Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85855623
70Tight junction_Homo sapiens_hsa045300.85494238
71Cysteine and methionine metabolism_Homo sapiens_hsa002700.85437450
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84728151
73Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84716400
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.84701699
75Taste transduction_Homo sapiens_hsa047420.84608744
76ECM-receptor interaction_Homo sapiens_hsa045120.84233429
77Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83582116
78Starch and sucrose metabolism_Homo sapiens_hsa005000.83566910
79Renin secretion_Homo sapiens_hsa049240.82588273
80Olfactory transduction_Homo sapiens_hsa047400.81569244
81Renin-angiotensin system_Homo sapiens_hsa046140.81548749
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79705977
83Fatty acid metabolism_Homo sapiens_hsa012120.79036950
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.78466700
85Mineral absorption_Homo sapiens_hsa049780.78181012
86Fatty acid degradation_Homo sapiens_hsa000710.77900624
87Wnt signaling pathway_Homo sapiens_hsa043100.76787076
88Sphingolipid metabolism_Homo sapiens_hsa006000.76349572
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74391923
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.72425098
91Axon guidance_Homo sapiens_hsa043600.72414597
92N-Glycan biosynthesis_Homo sapiens_hsa005100.72045221
93mTOR signaling pathway_Homo sapiens_hsa041500.71486395
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70561627
95GABAergic synapse_Homo sapiens_hsa047270.69532372
96Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.69372030
97Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68751014
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67620387
99Cholinergic synapse_Homo sapiens_hsa047250.67357183
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66810428
101beta-Alanine metabolism_Homo sapiens_hsa004100.66272188
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.65464921
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65254750
104Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.65251565
105Arginine and proline metabolism_Homo sapiens_hsa003300.64306453
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63811824
107Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63737507
108AMPK signaling pathway_Homo sapiens_hsa041520.62868793
109mRNA surveillance pathway_Homo sapiens_hsa030150.61626548
110Long-term depression_Homo sapiens_hsa047300.61178982
111Linoleic acid metabolism_Homo sapiens_hsa005910.61068973
112Fatty acid biosynthesis_Homo sapiens_hsa000610.60893339
113Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60358408
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.59522627
115Serotonergic synapse_Homo sapiens_hsa047260.59405365
116RNA polymerase_Homo sapiens_hsa030200.57760346
117Gap junction_Homo sapiens_hsa045400.57440436
118cAMP signaling pathway_Homo sapiens_hsa040240.56882433
119TGF-beta signaling pathway_Homo sapiens_hsa043500.56124126
120Cell cycle_Homo sapiens_hsa041100.55899023
121Steroid biosynthesis_Homo sapiens_hsa001000.55564597
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.55098348
123Glutamatergic synapse_Homo sapiens_hsa047240.53981241
124Ovarian steroidogenesis_Homo sapiens_hsa049130.53796952
125Propanoate metabolism_Homo sapiens_hsa006400.53327695
126PPAR signaling pathway_Homo sapiens_hsa033200.53325458
127Insulin signaling pathway_Homo sapiens_hsa049100.52417386
128Endometrial cancer_Homo sapiens_hsa052130.52060809
129Proteoglycans in cancer_Homo sapiens_hsa052050.50999296
130Focal adhesion_Homo sapiens_hsa045100.50973977
131Dilated cardiomyopathy_Homo sapiens_hsa054140.50731081
132Prion diseases_Homo sapiens_hsa050200.49831098
133Glycerolipid metabolism_Homo sapiens_hsa005610.49803489
134Metabolic pathways_Homo sapiens_hsa011000.49616029
135Arachidonic acid metabolism_Homo sapiens_hsa005900.49535107
136Prostate cancer_Homo sapiens_hsa052150.49486546
137Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49450474
138Gastric acid secretion_Homo sapiens_hsa049710.48871532
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47771692
140Bladder cancer_Homo sapiens_hsa052190.47458554
141Histidine metabolism_Homo sapiens_hsa003400.46666448
142Pyruvate metabolism_Homo sapiens_hsa006200.46441524
143Salivary secretion_Homo sapiens_hsa049700.45310156
144GnRH signaling pathway_Homo sapiens_hsa049120.45146279

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