FAM135B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.68700558
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.68013743
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.15763675
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.09792437
5vocalization behavior (GO:0071625)5.09494523
6glutamate secretion (GO:0014047)5.02263317
7protein localization to synapse (GO:0035418)4.93246829
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.83626849
9regulation of synaptic vesicle exocytosis (GO:2000300)4.81008990
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.76511125
11dendritic spine morphogenesis (GO:0060997)4.66413282
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.60723561
13synaptic vesicle maturation (GO:0016188)4.60578909
14locomotory exploration behavior (GO:0035641)4.60354222
15neuron cell-cell adhesion (GO:0007158)4.57248402
16glutamate receptor signaling pathway (GO:0007215)4.50998904
17regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.42839510
18synaptic transmission, glutamatergic (GO:0035249)4.39858894
19neuron-neuron synaptic transmission (GO:0007270)4.38067580
20G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.36892146
21gamma-aminobutyric acid signaling pathway (GO:0007214)4.36570880
22regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.34297499
23regulation of glutamate receptor signaling pathway (GO:1900449)4.32187326
24neurotransmitter-gated ion channel clustering (GO:0072578)4.32112527
25regulation of synaptic vesicle transport (GO:1902803)4.26338567
26neurotransmitter secretion (GO:0007269)4.14084572
27positive regulation of synapse maturation (GO:0090129)4.10481186
28detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.09022914
29response to histamine (GO:0034776)4.08083945
30neuronal action potential propagation (GO:0019227)4.06077582
31exploration behavior (GO:0035640)4.00108317
32cerebellar Purkinje cell differentiation (GO:0021702)3.97114388
33cellular potassium ion homeostasis (GO:0030007)3.93010310
34long-term synaptic potentiation (GO:0060291)3.88765052
35protein K11-linked deubiquitination (GO:0035871)3.88342351
36negative regulation of cytosolic calcium ion concentration (GO:0051481)3.86140560
37righting reflex (GO:0060013)3.85847320
38regulation of excitatory postsynaptic membrane potential (GO:0060079)3.82544301
39synaptic vesicle endocytosis (GO:0048488)3.76289854
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.75749856
41regulation of postsynaptic membrane potential (GO:0060078)3.75046070
42membrane depolarization during action potential (GO:0086010)3.70473972
43presynaptic membrane assembly (GO:0097105)3.69293546
44long-term memory (GO:0007616)3.68405107
45innervation (GO:0060384)3.67672573
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.67487580
47regulation of neuronal synaptic plasticity (GO:0048168)3.60669746
48cerebellar granule cell differentiation (GO:0021707)3.56734122
49retinal cone cell development (GO:0046549)3.54344512
50neurotransmitter transport (GO:0006836)3.51535637
51primary amino compound metabolic process (GO:1901160)3.51017889
52regulation of synaptic transmission, glutamatergic (GO:0051966)3.49437550
53positive regulation of membrane potential (GO:0045838)3.49211874
54neuronal ion channel clustering (GO:0045161)3.48385370
55negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.46029982
56behavioral response to cocaine (GO:0048148)3.45122254
57regulation of neurotransmitter secretion (GO:0046928)3.41564146
58detection of light stimulus involved in visual perception (GO:0050908)3.40528905
59detection of light stimulus involved in sensory perception (GO:0050962)3.40528905
60presynaptic membrane organization (GO:0097090)3.39699668
61gamma-aminobutyric acid transport (GO:0015812)3.38862391
62calcium ion-dependent exocytosis (GO:0017156)3.37623664
63cilium or flagellum-dependent cell motility (GO:0001539)3.37208540
64potassium ion transmembrane transport (GO:0071805)3.36637032
65cellular potassium ion transport (GO:0071804)3.36637032
66negative regulation of synaptic transmission, GABAergic (GO:0032229)3.35838082
67striatum development (GO:0021756)3.33804505
68acrosome reaction (GO:0007340)3.33033660
69membrane depolarization (GO:0051899)3.32362492
70regulation of vesicle fusion (GO:0031338)3.32008674
71regulation of synaptic plasticity (GO:0048167)3.29976010
72prepulse inhibition (GO:0060134)3.29551276
73membrane hyperpolarization (GO:0060081)3.27624622
74regulation of synapse structural plasticity (GO:0051823)3.27532082
75neurofilament cytoskeleton organization (GO:0060052)3.26096792
76postsynaptic membrane organization (GO:0001941)3.25390886
77transmission of nerve impulse (GO:0019226)3.24123143
78regulation of synapse maturation (GO:0090128)3.23966914
79regulation of neurotransmitter transport (GO:0051588)3.22139206
80neuron recognition (GO:0008038)3.21885291
81chemosensory behavior (GO:0007635)3.21457391
82positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.21301590
83startle response (GO:0001964)3.20827782
84neuronal action potential (GO:0019228)3.20071657
85positive regulation of neurotransmitter transport (GO:0051590)3.17761727
86regulation of neurotransmitter levels (GO:0001505)3.14413287
87regulation of neurotransmitter uptake (GO:0051580)3.12750244
88urinary tract smooth muscle contraction (GO:0014848)3.12717540
89mating behavior (GO:0007617)3.11942796
90synapse assembly (GO:0007416)3.11875305
91behavioral defense response (GO:0002209)3.10876008
92behavioral fear response (GO:0001662)3.10876008
93positive regulation of neurotransmitter secretion (GO:0001956)3.10479553
94potassium ion transport (GO:0006813)3.09896548
95establishment of synaptic vesicle localization (GO:0097480)3.07561978
96synaptic vesicle transport (GO:0048489)3.07561978
97dendritic spine organization (GO:0097061)3.06719081
98synaptic transmission (GO:0007268)3.06696691
99regulation of calcium ion-dependent exocytosis (GO:0017158)3.04665496
100calcium ion import (GO:0070509)3.03006202
101cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02261061
102positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.02070187
103positive regulation of dendritic spine morphogenesis (GO:0061003)3.02039830
104learning (GO:0007612)3.01409159
105fear response (GO:0042596)3.01402554
106positive regulation of synaptic transmission (GO:0050806)2.99894279
107layer formation in cerebral cortex (GO:0021819)2.99441195
108reflex (GO:0060004)2.99309398
109long term synaptic depression (GO:0060292)2.98739644
110sodium ion export (GO:0071436)2.98280434
111positive regulation of synaptic transmission, GABAergic (GO:0032230)2.98035771
112proline transport (GO:0015824)2.97002401
113behavioral response to nicotine (GO:0035095)2.96772209
114axonal fasciculation (GO:0007413)2.96203284
115sperm motility (GO:0030317)2.94909071
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.94624565
117regulation of dendritic spine morphogenesis (GO:0061001)2.94353897
118cellular ketone body metabolic process (GO:0046950)2.93897100
119regulation of voltage-gated calcium channel activity (GO:1901385)2.93719608
120response to pheromone (GO:0019236)2.93362915
121neuromuscular process controlling posture (GO:0050884)2.93204110
122serotonin metabolic process (GO:0042428)2.91383302
123seminiferous tubule development (GO:0072520)2.90548315
124regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.89695520
125cell differentiation in hindbrain (GO:0021533)2.88869428
126positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88662182
127cochlea development (GO:0090102)2.87677324
128activation of protein kinase A activity (GO:0034199)2.87101102
129positive regulation of dendritic spine development (GO:0060999)2.83342860
130retina layer formation (GO:0010842)2.82232471
131neuromuscular synaptic transmission (GO:0007274)2.79518056
132tooth mineralization (GO:0034505)2.79279804
133detection of chemical stimulus involved in sensory perception (GO:0050907)2.76862295
134response to dietary excess (GO:0002021)2.75842747
135C4-dicarboxylate transport (GO:0015740)2.75146575
136detection of calcium ion (GO:0005513)2.70325550
137response to auditory stimulus (GO:0010996)2.68495218
138synaptic transmission, dopaminergic (GO:0001963)2.66045603
139axon ensheathment in central nervous system (GO:0032291)2.65401672
140central nervous system myelination (GO:0022010)2.65401672
141protein polyglutamylation (GO:0018095)2.64742312
142nucleobase catabolic process (GO:0046113)2.63384804
143ketone body metabolic process (GO:1902224)2.61148984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.51182401
2GBX2_23144817_ChIP-Seq_PC3_Human4.35513793
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73204376
4REST_21632747_ChIP-Seq_MESCs_Mouse2.69102534
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.62622485
6ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.62201074
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.61051440
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.57875626
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.53504547
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.26951887
11* DROSHA_22980978_ChIP-Seq_HELA_Human2.25413331
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23426048
13TAF15_26573619_Chip-Seq_HEK293_Human2.22775812
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.20780543
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20084834
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.18326659
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.13283913
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.13283913
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.12752047
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12434103
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.12386855
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11737950
23ZFP57_27257070_Chip-Seq_ESCs_Mouse2.07946816
24* RARB_27405468_Chip-Seq_BRAIN_Mouse2.06009294
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.05253613
26* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.03857444
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.00126532
28* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98939298
29SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.97521697
30SMAD4_21799915_ChIP-Seq_A2780_Human1.94493674
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.93002803
32* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92166448
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.85482785
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70770038
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.70699403
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69516359
37CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.69462447
38ZNF274_21170338_ChIP-Seq_K562_Hela1.65790534
39P300_19829295_ChIP-Seq_ESCs_Human1.64302410
40POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63129367
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.58673424
42IGF1R_20145208_ChIP-Seq_DFB_Human1.55825871
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.50487467
44* SMAD3_21741376_ChIP-Seq_EPCs_Human1.49525255
45* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47549271
46FUS_26573619_Chip-Seq_HEK293_Human1.46616919
47* STAT3_23295773_ChIP-Seq_U87_Human1.46603488
48AR_21572438_ChIP-Seq_LNCaP_Human1.45583033
49* AR_25329375_ChIP-Seq_VCAP_Human1.45209431
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.44607307
51BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41761084
52PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.41475868
53* TCF4_23295773_ChIP-Seq_U87_Human1.36501586
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.34904611
55VDR_22108803_ChIP-Seq_LS180_Human1.34092371
56SOX2_21211035_ChIP-Seq_LN229_Gbm1.33139813
57RNF2_27304074_Chip-Seq_NSC_Mouse1.32317456
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31245560
59OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30010888
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28957106
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28363308
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27737558
63SMAD4_21741376_ChIP-Seq_EPCs_Human1.26195666
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.25101889
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24846804
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24538119
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21878815
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20947282
69NANOG_18555785_Chip-Seq_ESCs_Mouse1.19773096
70AR_19668381_ChIP-Seq_PC3_Human1.17208280
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16471958
72MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15073509
73* TCF4_22108803_ChIP-Seq_LS180_Human1.14785112
74POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14103675
75TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14103675
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.12345823
77P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11188579
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.11023022
79* SMAD4_21741376_ChIP-Seq_HESCs_Human1.10818892
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10385104
81ER_23166858_ChIP-Seq_MCF-7_Human1.10099184
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09957760
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09682233
84RUNX2_22187159_ChIP-Seq_PCA_Human1.09627397
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09431081
86YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09190636
87MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.08987400
88PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08976622
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07889054
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07634062
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06641169
92CBP_20019798_ChIP-Seq_JUKART_Human1.06641169
93RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06413136
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05993057
95* SMAD3_21741376_ChIP-Seq_HESCs_Human1.05682898
96KDM2B_26808549_Chip-Seq_REH_Human1.05620558
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04405737
98BCAT_22108803_ChIP-Seq_LS180_Human1.04125352
99TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03983483
100AHR_22903824_ChIP-Seq_MCF-7_Human1.03916083
101P53_22387025_ChIP-Seq_ESCs_Mouse1.03726044
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03034922
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.02960583
104NANOG_19829295_ChIP-Seq_ESCs_Human1.02920930
105SOX2_19829295_ChIP-Seq_ESCs_Human1.02920930
106RING1B_27294783_Chip-Seq_ESCs_Mouse1.01816884
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.01041043
108SMAD3_21741376_ChIP-Seq_ESCs_Human1.00961587
109SUZ12_27294783_Chip-Seq_NPCs_Mouse1.00823372
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00160429
111CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99857300
112CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99401457
113TP53_18474530_ChIP-ChIP_U2OS_Human0.99173738
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.98657132
115FLI1_21867929_ChIP-Seq_TH2_Mouse0.98560643
116ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98119182
117* SOX9_26525672_Chip-Seq_HEART_Mouse0.98055312
118CMYC_18555785_Chip-Seq_ESCs_Mouse0.97811074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.56288931
2MP0003880_abnormal_central_pattern4.82473595
3MP0003635_abnormal_synaptic_transmissio3.91467844
4MP0009046_muscle_twitch3.56876415
5MP0009745_abnormal_behavioral_response3.26803964
6MP0004270_analgesia3.21452916
7MP0002063_abnormal_learning/memory/cond3.18854884
8MP0002064_seizures3.05854009
9MP0001968_abnormal_touch/_nociception2.95964161
10MP0002572_abnormal_emotion/affect_behav2.82118747
11MP0002272_abnormal_nervous_system2.64875728
12MP0005423_abnormal_somatic_nervous2.49841676
13MP0002736_abnormal_nociception_after2.44482888
14MP0002734_abnormal_mechanical_nocicepti2.44345146
15MP0001486_abnormal_startle_reflex2.40416220
16MP0001984_abnormal_olfaction2.36521692
17MP0005084_abnormal_gallbladder_morpholo2.27851163
18MP0001501_abnormal_sleep_pattern2.25494789
19MP0002067_abnormal_sensory_capabilities2.15570311
20MP0005410_abnormal_fertilization2.06842179
21MP0003787_abnormal_imprinting2.05709423
22MP0002735_abnormal_chemical_nociception2.05232616
23MP0005551_abnormal_eye_electrophysiolog2.01585612
24MP0002909_abnormal_adrenal_gland1.99685221
25MP0001440_abnormal_grooming_behavior1.97117424
26MP0005646_abnormal_pituitary_gland1.91029880
27MP0008961_abnormal_basal_metabolism1.89122902
28MP0009780_abnormal_chondrocyte_physiolo1.88942268
29MP0008569_lethality_at_weaning1.88516130
30MP0002184_abnormal_innervation1.83714599
31MP0002822_catalepsy1.83277603
32MP0003879_abnormal_hair_cell1.80683234
33MP0005645_abnormal_hypothalamus_physiol1.73864235
34MP0001188_hyperpigmentation1.70426614
35MP0002557_abnormal_social/conspecific_i1.69191751
36MP0004924_abnormal_behavior1.68609659
37MP0005386_behavior/neurological_phenoty1.68609659
38MP0003195_calcinosis1.66814700
39MP0001970_abnormal_pain_threshold1.62780827
40MP0001529_abnormal_vocalization1.62480778
41MP0004811_abnormal_neuron_physiology1.59625621
42MP0001502_abnormal_circadian_rhythm1.58986739
43MP0002733_abnormal_thermal_nociception1.58776247
44MP0000778_abnormal_nervous_system1.55100383
45MP0003122_maternal_imprinting1.54633927
46MP0006276_abnormal_autonomic_nervous1.50955624
47MP0001485_abnormal_pinna_reflex1.42903780
48MP0002882_abnormal_neuron_morphology1.40162444
49MP0000955_abnormal_spinal_cord1.34235764
50MP0002066_abnormal_motor_capabilities/c1.34067565
51MP0000569_abnormal_digit_pigmentation1.33791435
52MP0001905_abnormal_dopamine_level1.33631266
53MP0002090_abnormal_vision1.31433995
54MP0006072_abnormal_retinal_apoptosis1.26440202
55MP0010386_abnormal_urinary_bladder1.26314577
56MP0003183_abnormal_peptide_metabolism1.26000746
57MP0003633_abnormal_nervous_system1.25791804
58MP0004142_abnormal_muscle_tone1.25642869
59MP0005379_endocrine/exocrine_gland_phen1.22222552
60MP0000631_abnormal_neuroendocrine_gland1.15214114
61MP0003329_amyloid_beta_deposits1.15017748
62MP0002229_neurodegeneration1.14653080
63MP0003136_yellow_coat_color1.12907604
64MP0004130_abnormal_muscle_cell1.11831244
65MP0004147_increased_porphyrin_level1.10957413
66MP0008877_abnormal_DNA_methylation1.09321076
67MP0004858_abnormal_nervous_system1.06028592
68MP0003631_nervous_system_phenotype1.04693189
69MP0004043_abnormal_pH_regulation1.03829943
70MP0002152_abnormal_brain_morphology1.03758182
71MP0005499_abnormal_olfactory_system1.03711705
72MP0005394_taste/olfaction_phenotype1.03711705
73MP0004145_abnormal_muscle_electrophysio1.03689204
74MP0005253_abnormal_eye_physiology1.03623156
75MP0003698_abnormal_male_reproductive1.03621279
76MP0001986_abnormal_taste_sensitivity1.01729614
77MP0002876_abnormal_thyroid_physiology1.01634433
78MP0004233_abnormal_muscle_weight0.99672795
79MP0002837_dystrophic_cardiac_calcinosis0.98879183
80MP0008872_abnormal_physiological_respon0.98785310
81MP0004215_abnormal_myocardial_fiber0.97791295
82MP0002069_abnormal_eating/drinking_beha0.93481904
83MP0002928_abnormal_bile_duct0.92829753
84MP0004742_abnormal_vestibular_system0.89048589
85MP0002752_abnormal_somatic_nervous0.88082289
86MP0001963_abnormal_hearing_physiology0.86965150
87MP0003011_delayed_dark_adaptation0.85529818
88MP0003878_abnormal_ear_physiology0.84996453
89MP0005377_hearing/vestibular/ear_phenot0.84996453
90MP0004885_abnormal_endolymph0.83276014
91MP0004133_heterotaxia0.82260369
92MP0004085_abnormal_heartbeat0.81967139
93MP0001944_abnormal_pancreas_morphology0.81519190
94MP0003252_abnormal_bile_duct0.80320837
95MP0003646_muscle_fatigue0.79353316
96MP0005448_abnormal_energy_balance0.78580046
97MP0005535_abnormal_body_temperature0.78540204
98MP0000920_abnormal_myelination0.76414362
99MP0000013_abnormal_adipose_tissue0.75942299
100MP0000026_abnormal_inner_ear0.75197400
101MP0000751_myopathy0.73821322
102MP0002693_abnormal_pancreas_physiology0.72493249
103MP0002751_abnormal_autonomic_nervous0.72333089
104MP0003632_abnormal_nervous_system0.72056743
105MP0008874_decreased_physiological_sensi0.71676810
106MP0001929_abnormal_gametogenesis0.67889641
107MP0001177_atelectasis0.67006099
108MP0003718_maternal_effect0.66889212
109MP0003121_genomic_imprinting0.66332868
110MP0002234_abnormal_pharynx_morphology0.66055197
111MP0002653_abnormal_ependyma_morphology0.65781722
112MP0003634_abnormal_glial_cell0.64115723
113MP0001299_abnormal_eye_distance/0.64058661
114MP0001664_abnormal_digestion0.63805002
115MP0003283_abnormal_digestive_organ0.63622668
116MP0005195_abnormal_posterior_eye0.60268314
117MP0002638_abnormal_pupillary_reflex0.59789700
118MP0003137_abnormal_impulse_conducting0.57330422
119MP0001943_abnormal_respiration0.57151271
120MP0001765_abnormal_ion_homeostasis0.57047147
121MP0010769_abnormal_survival0.55892922
122MP0006292_abnormal_olfactory_placode0.55749468
123MP0010770_preweaning_lethality0.55524297
124MP0002082_postnatal_lethality0.55524297
125MP0002161_abnormal_fertility/fecundity0.55297049

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.34773531
2Epileptic encephalopathy (HP:0200134)5.61385418
3Febrile seizures (HP:0002373)5.51219943
4Focal seizures (HP:0007359)5.11699965
5Atonic seizures (HP:0010819)5.08499731
6Myokymia (HP:0002411)4.98775134
7Progressive cerebellar ataxia (HP:0002073)4.87912763
8Absence seizures (HP:0002121)4.63830242
9Visual hallucinations (HP:0002367)4.41431844
10Congenital stationary night blindness (HP:0007642)4.21141391
11Dialeptic seizures (HP:0011146)4.12976328
12Hyperventilation (HP:0002883)3.85154700
13Gaze-evoked nystagmus (HP:0000640)3.85135689
14Generalized tonic-clonic seizures (HP:0002069)3.68390167
15Absent/shortened dynein arms (HP:0200106)3.58341495
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.58341495
17Dysdiadochokinesis (HP:0002075)3.46557580
18Amelogenesis imperfecta (HP:0000705)3.44266664
19Broad-based gait (HP:0002136)3.43840016
20Truncal ataxia (HP:0002078)3.30330228
21Action tremor (HP:0002345)3.21314136
22Polyuria (HP:0000103)3.16002671
23Dysmetric saccades (HP:0000641)3.00029885
24Epileptiform EEG discharges (HP:0011182)2.96569457
25Impaired smooth pursuit (HP:0007772)2.93869131
26Attenuation of retinal blood vessels (HP:0007843)2.91034686
27Bony spicule pigmentary retinopathy (HP:0007737)2.87905557
28Abnormality of midbrain morphology (HP:0002418)2.85552700
29Molar tooth sign on MRI (HP:0002419)2.85552700
30Impaired vibration sensation in the lower limbs (HP:0002166)2.83612083
31Dysmetria (HP:0001310)2.78878988
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.75342053
33Depression (HP:0000716)2.75228822
34Genetic anticipation (HP:0003743)2.73829665
35Abnormal urine output (HP:0012590)2.73622610
36Pheochromocytoma (HP:0002666)2.71732428
37Central scotoma (HP:0000603)2.70313883
38EEG with generalized epileptiform discharges (HP:0011198)2.69078067
39Gait imbalance (HP:0002141)2.68580453
40Drooling (HP:0002307)2.68131910
41Excessive salivation (HP:0003781)2.68131910
42Poor eye contact (HP:0000817)2.68044356
43Abnormality of ocular smooth pursuit (HP:0000617)2.64625867
44Abnormal eating behavior (HP:0100738)2.62197604
45Urinary bladder sphincter dysfunction (HP:0002839)2.61871745
46Abnormality of macular pigmentation (HP:0008002)2.58508293
47Abnormal drinking behavior (HP:0030082)2.56075736
48Polydipsia (HP:0001959)2.56075736
49Postural instability (HP:0002172)2.54317064
50Medial flaring of the eyebrow (HP:0010747)2.53162653
51Abnormality of the renal medulla (HP:0100957)2.52332126
52Scanning speech (HP:0002168)2.52182190
53Absent speech (HP:0001344)2.48755486
54Hemiparesis (HP:0001269)2.47225096
55Pancreatic cysts (HP:0001737)2.46131870
56Abnormal social behavior (HP:0012433)2.46071348
57Impaired social interactions (HP:0000735)2.46071348
58Limb dystonia (HP:0002451)2.45698990
59Amblyopia (HP:0000646)2.44596047
60Type II lissencephaly (HP:0007260)2.43640733
61Pancreatic fibrosis (HP:0100732)2.42906109
62Congenital primary aphakia (HP:0007707)2.42636831
63Anxiety (HP:0000739)2.42135468
64Neuroendocrine neoplasm (HP:0100634)2.37424849
65Hypothermia (HP:0002045)2.36245012
66Abnormal rod and cone electroretinograms (HP:0008323)2.34160177
67Abnormality of dental color (HP:0011073)2.33516525
68Hypsarrhythmia (HP:0002521)2.31942579
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.29233435
70Abnormality of renal excretion (HP:0011036)2.28691684
71Supranuclear gaze palsy (HP:0000605)2.26789752
72Abnormal respiratory motile cilium physiology (HP:0012261)2.26241225
73Bradykinesia (HP:0002067)2.26168346
74Chronic hepatic failure (HP:0100626)2.23653523
75True hermaphroditism (HP:0010459)2.21859403
76Nephrogenic diabetes insipidus (HP:0009806)2.21669194
77Abnormality of the lower motor neuron (HP:0002366)2.21484845
78Polyphagia (HP:0002591)2.21186969
79Impaired vibratory sensation (HP:0002495)2.17554330
80Protruding tongue (HP:0010808)2.13123212
81Abnormality of binocular vision (HP:0011514)2.09739912
82Diplopia (HP:0000651)2.09739912
83Ankle clonus (HP:0011448)2.08005794
84Abnormal respiratory motile cilium morphology (HP:0005938)2.06834228
85Abnormal respiratory epithelium morphology (HP:0012253)2.06834228
86Status epilepticus (HP:0002133)2.04874514
87Blue irides (HP:0000635)2.04433424
88Abnormal hair whorl (HP:0010721)2.04352131
89Abnormal ciliary motility (HP:0012262)2.02209630
90Fetal akinesia sequence (HP:0001989)2.01909296
91Inability to walk (HP:0002540)2.00035792
92Hemiplegia (HP:0002301)1.99119041
93Progressive inability to walk (HP:0002505)1.99092060
94Mutism (HP:0002300)1.97109987
95Increased circulating renin level (HP:0000848)1.96867589
96Spastic gait (HP:0002064)1.95052995
97Cerebellar dysplasia (HP:0007033)1.94211246
98Abnormality of renal resorption (HP:0011038)1.94030112
99Torticollis (HP:0000473)1.93648751
100Vaginal atresia (HP:0000148)1.92617020
101Decreased central vision (HP:0007663)1.92468872
102Genital tract atresia (HP:0001827)1.92038332
103Optic nerve hypoplasia (HP:0000609)1.91453331
104Specific learning disability (HP:0001328)1.91347811
105Gait ataxia (HP:0002066)1.91136543
106Widely spaced teeth (HP:0000687)1.88165479
107Failure to thrive in infancy (HP:0001531)1.86811048
108Stereotypic behavior (HP:0000733)1.86163258
109Focal dystonia (HP:0004373)1.85300666
110Large for gestational age (HP:0001520)1.84797765
111Hypomagnesemia (HP:0002917)1.84620697
112Abnormality of the renal cortex (HP:0011035)1.84452549
113Poor coordination (HP:0002370)1.84082366
114Aqueductal stenosis (HP:0002410)1.83527632
115Hypoventilation (HP:0002791)1.83460868
116Incomplete penetrance (HP:0003829)1.82463536
117Congenital sensorineural hearing impairment (HP:0008527)1.82311123
118Infertility (HP:0000789)1.81829637
119Abnormality of saccadic eye movements (HP:0000570)1.81664993
120Labial hypoplasia (HP:0000066)1.80077764
121Rhinitis (HP:0012384)1.80072963
122Tubulointerstitial nephritis (HP:0001970)1.79887678
123Nephronophthisis (HP:0000090)1.79757163
124Cystic liver disease (HP:0006706)1.79497237
125Prolonged QT interval (HP:0001657)1.75930944
126Generalized myoclonic seizures (HP:0002123)1.75607070
127Intention tremor (HP:0002080)1.74916828
128Intestinal atresia (HP:0011100)1.74506732
129Akinesia (HP:0002304)1.73661089
130Agitation (HP:0000713)1.73421941
131Abnormality of salivation (HP:0100755)1.72537354
132Abnormal gallbladder physiology (HP:0012438)1.72408245
133Cholecystitis (HP:0001082)1.72408245
134Limb ataxia (HP:0002070)1.70338455
135Severe visual impairment (HP:0001141)1.70233444

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.95056823
2NTRK34.45625027
3EPHA43.82562245
4MAP3K43.53671098
5CASK3.25673899
6MAP2K73.17824214
7MAP4K22.76542683
8MARK12.65073321
9MAP3K92.57162118
10MAP3K122.31554221
11MINK12.18838494
12DAPK22.16577672
13PRPF4B2.13253537
14MAP2K41.92801677
15AKT31.90098732
16CDK191.89026023
17DAPK11.81193838
18BMPR1B1.80556164
19NTRK21.78671001
20PAK61.78436096
21PLK21.75377332
22PRKD31.71621381
23CAMKK21.66769409
24TNIK1.56437466
25ADRBK21.54090208
26PNCK1.53223078
27RIPK41.52272252
28PDK41.50964752
29PDK31.50964752
30STK381.48439975
31CAMKK11.46390300
32MAPK131.40974073
33GRK11.37346367
34PRKCG1.32494852
35KSR11.31079342
36SGK21.27086845
37CDK51.26979944
38STK38L1.25924198
39CAMK2A1.20849250
40GRK51.20064892
41SGK4941.18357328
42SGK2231.18357328
43PTK2B1.13487455
44CCNB11.09582835
45OXSR11.09183094
46ACVR1B1.06156521
47CAMK2B1.04495876
48KSR21.04475026
49INSRR1.02040466
50NTRK10.98040519
51FGFR20.97834467
52FES0.97178088
53STK30.93542405
54WNK30.90618556
55PDK20.89895623
56CDK180.85951405
57ARAF0.85528244
58STK390.84629718
59CAMK10.83579263
60SGK30.82975253
61NME10.82065000
62CDK150.81946212
63DYRK1A0.78813714
64BMPR20.78690837
65CSNK1G10.78064177
66CSNK1G30.77864581
67CDK30.77776191
68SGK10.76196393
69PLK40.73301070
70CDK140.72958655
71BRAF0.72527325
72STK110.72207824
73PDK10.72129379
74DYRK20.71862642
75WNK10.71485075
76CAMK2D0.71264043
77CAMK1G0.69830669
78CDC42BPA0.69675447
79CSNK1G20.69556233
80CDK11A0.68945789
81MAP3K20.68710629
82PKN10.65948377
83FER0.64034086
84PRKCH0.63659735
85UHMK10.63444933
86SIK20.62397143
87MARK20.61275558
88PRKCE0.56639634
89PHKG20.55593913
90PHKG10.55593913
91CSNK1A10.55529087
92PINK10.55008205
93TAOK30.54865517
94ICK0.53134885
95CSNK1D0.52088771
96MAPK150.51861831
97NEK60.50903595
98PDPK10.50208192
99RPS6KA30.50028447
100MAP3K130.49417843
101ERBB30.48860081
102PRKAA10.47646744
103PAK30.47635860
104TNK20.46987749
105MAP2K60.46929727
106ADRBK10.46562719
107SIK30.46488031
108NEK10.46394278
109MKNK20.46379582
110PRKG20.46285104
111CAMK2G0.46123946
112CSNK1A1L0.44956023
113MAPKAPK50.44359477
114PRKCZ0.43982829
115PRKG10.43750377
116RAF10.42131797
117PRKACB0.41841724
118RET0.41052000
119TYRO30.40580164
120PRKCB0.39708238
121MAP3K60.39501289
122TAOK10.38991218
123CAMK40.38688375
124ZAK0.38588758
125ROCK10.38160593
126PRKCA0.38054090
127TRIM280.36946001
128PRKACA0.36879639
129WNK40.34842848
130TESK10.34244530
131ROCK20.32290570

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.44509234
2Synaptic vesicle cycle_Homo sapiens_hsa047213.67252679
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.94688882
4GABAergic synapse_Homo sapiens_hsa047272.90032289
5Morphine addiction_Homo sapiens_hsa050322.82455768
6Circadian entrainment_Homo sapiens_hsa047132.81439041
7Amphetamine addiction_Homo sapiens_hsa050312.76834111
8Long-term potentiation_Homo sapiens_hsa047202.59741408
9Olfactory transduction_Homo sapiens_hsa047402.58142228
10Glutamatergic synapse_Homo sapiens_hsa047242.57421957
11Insulin secretion_Homo sapiens_hsa049112.33455457
12Dopaminergic synapse_Homo sapiens_hsa047282.19857589
13Salivary secretion_Homo sapiens_hsa049702.19440807
14Collecting duct acid secretion_Homo sapiens_hsa049662.18209250
15Taste transduction_Homo sapiens_hsa047422.13896632
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.01728633
17Renin secretion_Homo sapiens_hsa049241.83339068
18Serotonergic synapse_Homo sapiens_hsa047261.82973669
19Cholinergic synapse_Homo sapiens_hsa047251.82918541
20Cocaine addiction_Homo sapiens_hsa050301.81672565
21Butanoate metabolism_Homo sapiens_hsa006501.80042015
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.77501580
23Calcium signaling pathway_Homo sapiens_hsa040201.68583969
24Long-term depression_Homo sapiens_hsa047301.59563390
25Gastric acid secretion_Homo sapiens_hsa049711.58904469
26Maturity onset diabetes of the young_Homo sapiens_hsa049501.54598454
27Oxytocin signaling pathway_Homo sapiens_hsa049211.53012971
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.45349574
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45327388
30Vibrio cholerae infection_Homo sapiens_hsa051101.43503110
31Phototransduction_Homo sapiens_hsa047441.36415849
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.35672332
33Type II diabetes mellitus_Homo sapiens_hsa049301.28825824
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26304121
35Nitrogen metabolism_Homo sapiens_hsa009101.24995702
36cAMP signaling pathway_Homo sapiens_hsa040241.23794792
37Linoleic acid metabolism_Homo sapiens_hsa005911.23281212
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22284615
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20194173
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16127654
41Gap junction_Homo sapiens_hsa045401.15285539
42GnRH signaling pathway_Homo sapiens_hsa049121.13793363
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.10881583
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.10384514
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.09384487
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.08850162
47ABC transporters_Homo sapiens_hsa020101.05442223
48Cardiac muscle contraction_Homo sapiens_hsa042601.02052627
49Estrogen signaling pathway_Homo sapiens_hsa049150.97765072
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.97081343
51Circadian rhythm_Homo sapiens_hsa047100.96403174
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91546849
53Pancreatic secretion_Homo sapiens_hsa049720.90660103
54Ether lipid metabolism_Homo sapiens_hsa005650.90516314
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.86111208
56Sulfur metabolism_Homo sapiens_hsa009200.83110967
57Axon guidance_Homo sapiens_hsa043600.82328148
58ErbB signaling pathway_Homo sapiens_hsa040120.82011071
59Thyroid hormone synthesis_Homo sapiens_hsa049180.79614857
60Fatty acid biosynthesis_Homo sapiens_hsa000610.79219901
61Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78101159
62Glucagon signaling pathway_Homo sapiens_hsa049220.77980359
63Tryptophan metabolism_Homo sapiens_hsa003800.77437206
64Glioma_Homo sapiens_hsa052140.77027036
65Melanogenesis_Homo sapiens_hsa049160.75518417
66Alcoholism_Homo sapiens_hsa050340.70105751
67Oocyte meiosis_Homo sapiens_hsa041140.69873061
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67909189
69MAPK signaling pathway_Homo sapiens_hsa040100.65765991
70beta-Alanine metabolism_Homo sapiens_hsa004100.65026609
71Dilated cardiomyopathy_Homo sapiens_hsa054140.62669210
72Inositol phosphate metabolism_Homo sapiens_hsa005620.61077285
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60656367
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.57534009
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.54267193
76Alzheimers disease_Homo sapiens_hsa050100.54168982
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52778177
78Dorso-ventral axis formation_Homo sapiens_hsa043200.52699266
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51981996
80Choline metabolism in cancer_Homo sapiens_hsa052310.51400809
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50649839
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49688816
83Histidine metabolism_Homo sapiens_hsa003400.48590594
84Ras signaling pathway_Homo sapiens_hsa040140.48474761
85Rheumatoid arthritis_Homo sapiens_hsa053230.47174288
86Oxidative phosphorylation_Homo sapiens_hsa001900.46278504
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45018429
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44436674
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42159204
90mTOR signaling pathway_Homo sapiens_hsa041500.41017040
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39894741
92Propanoate metabolism_Homo sapiens_hsa006400.39375193
93Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38563298
94Mineral absorption_Homo sapiens_hsa049780.37665787
95Fat digestion and absorption_Homo sapiens_hsa049750.36886810
96Type I diabetes mellitus_Homo sapiens_hsa049400.36202231
97Parkinsons disease_Homo sapiens_hsa050120.34265288
98Vitamin B6 metabolism_Homo sapiens_hsa007500.34172577
99Sulfur relay system_Homo sapiens_hsa041220.33131079
100Pyruvate metabolism_Homo sapiens_hsa006200.32714712
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32412815
102Ovarian steroidogenesis_Homo sapiens_hsa049130.32366556
103Rap1 signaling pathway_Homo sapiens_hsa040150.32342879
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.31957835
105Steroid hormone biosynthesis_Homo sapiens_hsa001400.31537918
106Wnt signaling pathway_Homo sapiens_hsa043100.31506058
107Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31256156
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31176011
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.30329004
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.29830512
111VEGF signaling pathway_Homo sapiens_hsa043700.29492418
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.27642954
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27603266
114Regulation of autophagy_Homo sapiens_hsa041400.26906597
115Bile secretion_Homo sapiens_hsa049760.26703128
116Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26217335
117Retinol metabolism_Homo sapiens_hsa008300.25311334
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25211152
119Insulin signaling pathway_Homo sapiens_hsa049100.25060715
120Sphingolipid metabolism_Homo sapiens_hsa006000.24829641
121Glycerolipid metabolism_Homo sapiens_hsa005610.24653715
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.23754574
123African trypanosomiasis_Homo sapiens_hsa051430.23612456
124Endocytosis_Homo sapiens_hsa041440.22135857
125Phagosome_Homo sapiens_hsa041450.20372043
126Endometrial cancer_Homo sapiens_hsa052130.20169086
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.20109146
128Fructose and mannose metabolism_Homo sapiens_hsa000510.20088933

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