ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cytidine deamination (GO:0009972)	7.74373553
2	cytidine metabolic process (GO:0046087)	7.74373553
3	cytidine catabolic process (GO:0006216)	7.74373553
4	DNA deamination (GO:0045006)	7.55239277
5	pyrimidine ribonucleoside catabolic process (GO:0046133)	6.76863029
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.44870928
7	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	5.06851063
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.63204847
9	ATP synthesis coupled proton transport (GO:0015986)	4.63204847
10	peptidyl-histidine modification (GO:0018202)	4.59161048
11	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.48166352
12	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.25987323
13	regulation of oxidative phosphorylation (GO:0002082)	4.17715408
14	respiratory electron transport chain (GO:0022904)	3.99738852
15	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.99313968
16	electron transport chain (GO:0022900)	3.96032440
17	mannosylation (GO:0097502)	3.73467869
18	tryptophan metabolic process (GO:0006568)	3.60631507
19	antigen processing and presentation via MHC class Ib (GO:0002475)	3.47778507
20	protein complex biogenesis (GO:0070271)	3.45104547
21	cellular response to interferon-beta (GO:0035458)	3.45021903
22	indole-containing compound catabolic process (GO:0042436)	3.44666499
23	indolalkylamine catabolic process (GO:0046218)	3.44666499
24	tryptophan catabolic process (GO:0006569)	3.44666499
25	pyrimidine nucleoside catabolic process (GO:0046135)	3.44651751
26	negative regulation by host of viral transcription (GO:0043922)	3.31510630
27	intracellular protein transmembrane import (GO:0044743)	3.30900053
28	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.29591707
29	termination of RNA polymerase III transcription (GO:0006386)	3.29591707
30	positive regulation of TOR signaling (GO:0032008)	3.26672994
31	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20789351
32	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20789351
33	NADH dehydrogenase complex assembly (GO:0010257)	3.20789351
34	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.14823062
35	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.14823062
36	negative T cell selection (GO:0043383)	3.13211176
37	eosinophil chemotaxis (GO:0048245)	3.11078469
38	cellular response to interleukin-15 (GO:0071350)	3.09409422
39	regulation of autophagic vacuole assembly (GO:2000785)	3.07880766
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.07799046
41	regulation of cellular respiration (GO:0043457)	3.05012302
42	response to interferon-beta (GO:0035456)	3.04727907
43	regulation of mitochondrial translation (GO:0070129)	2.97496467
44	hydrogen ion transmembrane transport (GO:1902600)	2.97318585
45	positive thymic T cell selection (GO:0045059)	2.95212988
46	pyrimidine ribonucleoside metabolic process (GO:0046131)	2.86111772
47	positive T cell selection (GO:0043368)	2.84566434
48	regulation of cellular amino acid metabolic process (GO:0006521)	2.84373511
49	metallo-sulfur cluster assembly (GO:0031163)	2.82064201
50	iron-sulfur cluster assembly (GO:0016226)	2.82064201
51	eosinophil migration (GO:0072677)	2.81149279
52	proteasome assembly (GO:0043248)	2.80413114
53	indolalkylamine metabolic process (GO:0006586)	2.76885074
54	macrophage chemotaxis (GO:0048246)	2.75089694
55	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.71884994
56	ATP biosynthetic process (GO:0006754)	2.68024867
57	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.68001841
58	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.67908855
59	aromatic amino acid family catabolic process (GO:0009074)	2.67516570
60	ubiquinone biosynthetic process (GO:0006744)	2.67477545
61	2-deoxyribonucleotide biosynthetic process (GO:0009265)	2.66857780
62	deoxyribose phosphate biosynthetic process (GO:0046385)	2.66857780
63	protein-cofactor linkage (GO:0018065)	2.63104583
64	proton transport (GO:0015992)	2.62905540
65	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	2.62857657
66	DNA demethylation (GO:0080111)	2.61108396
67	S-adenosylmethionine metabolic process (GO:0046500)	2.60635625
68	pyrimidine nucleoside metabolic process (GO:0006213)	2.59923939
69	negative regulation of T cell apoptotic process (GO:0070233)	2.56560213
70	hydrogen transport (GO:0006818)	2.56182963
71	negative regulation of B cell apoptotic process (GO:0002903)	2.55753086
72	L-fucose catabolic process (GO:0042355)	2.55508326
73	fucose catabolic process (GO:0019317)	2.55508326
74	L-fucose metabolic process (GO:0042354)	2.55508326
75	negative thymic T cell selection (GO:0045060)	2.55319611
76	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.55188844
77	regulation of meiosis I (GO:0060631)	2.54397304
78	necroptotic process (GO:0070266)	2.53944239
79	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.53741330
80	positive regulation of interleukin-8 secretion (GO:2000484)	2.52398958
81	negative regulation of ligase activity (GO:0051352)	2.51346086
82	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.51346086
83	regulation of activation of Janus kinase activity (GO:0010533)	2.51207544
84	regulation of B cell apoptotic process (GO:0002902)	2.50395562
85	cytochrome complex assembly (GO:0017004)	2.49356526
86	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.49333471
87	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48757292
88	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.45359058
89	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.45359058
90	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.45359058
91	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.45193000
92	signal peptide processing (GO:0006465)	2.43790860
93	deoxyribonucleotide biosynthetic process (GO:0009263)	2.43053664
94	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.42550595
95	positive regulation of T cell differentiation in thymus (GO:0033089)	2.42424754
96	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.42324009
97	oxidative phosphorylation (GO:0006119)	2.41917864
98	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	2.41464088
99	regulation of cilium movement (GO:0003352)	2.40453623
100	regulation of interleukin-8 secretion (GO:2000482)	2.40202008

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	5.89098388
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.70785632
3	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.21921358
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.98752514
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.83242474
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.47260727
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.42399444
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.32999558
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.26735039
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.06796796
11	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.04424160
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.89887637
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.54086696
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.29729645
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.28648881
16	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.25684614
17	ZNF274_21170338_ChIP-Seq_K562_Hela	2.13057719
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.11777527
19	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.09960754
20	FOXP3_21729870_ChIP-Seq_TREG_Human	2.05971663
21	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.97160077
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.93445530
23	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90784189
24	ELK1_19687146_ChIP-ChIP_HELA_Human	1.83667114
25	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.77059730
26	E2F7_22180533_ChIP-Seq_HELA_Human	1.69479766
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63749205
28	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.62783784
29	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.60744118
30	TAF15_26573619_Chip-Seq_HEK293_Human	1.56205553
31	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.56003280
32	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.55802986
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50414927
34	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.45359933
35	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.45267209
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.44510148
37	TP53_22573176_ChIP-Seq_HFKS_Human	1.41979861
38	DCP1A_22483619_ChIP-Seq_HELA_Human	1.41654657
39	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.36590472
40	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.35285388
41	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.34444717
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.34285244
43	MYB_26560356_Chip-Seq_TH2_Human	1.32669510
44	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.31916942
45	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.28909101
46	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.26933091
47	GATA3_26560356_Chip-Seq_TH2_Human	1.20255910
48	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.17828085
49	GATA3_27048872_Chip-Seq_THYMUS_Human	1.17708606
50	GABP_19822575_ChIP-Seq_HepG2_Human	1.15429553
51	AR_20517297_ChIP-Seq_VCAP_Human	1.14295242
52	ZNF263_19887448_ChIP-Seq_K562_Human	1.10052104
53	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07529123
54	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06908467
55	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06702396
56	TAF2_19829295_ChIP-Seq_ESCs_Human	1.04434666
57	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03814038
58	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03030608
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03030608
60	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.02821328
61	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.02752476
62	E2F1_20622854_ChIP-Seq_HELA_Human	1.02714834
63	MYB_26560356_Chip-Seq_TH1_Human	1.02072978
64	CIITA_25753668_ChIP-Seq_RAJI_Human	1.01750197
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.01375282
66	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.00372739
67	RBPJ_21746931_ChIP-Seq_IB4_Human	0.99559190
68	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	0.99529442
69	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.99263617
70	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.97979544
71	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.96404629
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.95821181
73	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95363110
74	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.95180982
75	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.94894694
76	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.91836480
77	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.90838086
78	P300_27268052_Chip-Seq_Bcells_Human	0.90629205
79	RUNX_20019798_ChIP-Seq_JUKART_Human	0.90112707
80	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89728757
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.89693965
82	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88680077
83	BCL6_27268052_Chip-Seq_Bcells_Human	0.88157816
84	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.87947689
85	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.87926977
86	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.87736226
87	KDM5A_27292631_Chip-Seq_BREAST_Human	0.86958040
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.86949984
89	CTCF_20526341_ChIP-Seq_ESCs_Human	0.86156348
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85913811
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.85713427
92	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.83367289
93	NCOR_22424771_ChIP-Seq_293T_Human	0.83347075
94	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.83282821
95	P53_21459846_ChIP-Seq_SAOS-2_Human	0.82659699
96	BCOR_27268052_Chip-Seq_Bcells_Human	0.82431678
97	PHF8_20622853_ChIP-Seq_HELA_Human	0.81773701
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.81647479
99	SPI1_23547873_ChIP-Seq_NB4_Human	0.81138922
100	NANOG_20526341_ChIP-Seq_ESCs_Human	0.81123173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	8.37571409
2	MP0000569_abnormal_digit_pigmentation	3.14744285
3	MP0005671_abnormal_response_to	3.06517989
4	MP0003806_abnormal_nucleotide_metabolis	2.96311781
5	MP0002138_abnormal_hepatobiliary_system	2.47187876
6	MP0001873_stomach_inflammation	2.39922376
7	MP0000538_abnormal_urinary_bladder	2.37610342
8	MP0002163_abnormal_gland_morphology	2.34884778
9	MP0006082_CNS_inflammation	2.24471245
10	MP0001984_abnormal_olfaction	2.01607148
11	MP0005084_abnormal_gallbladder_morpholo	2.00742636
12	MP0005379_endocrine/exocrine_gland_phen	1.92183018
13	MP0000372_irregular_coat_pigmentation	1.84462361
14	MP0001835_abnormal_antigen_presentation	1.83849673
15	MP0002148_abnormal_hypersensitivity_rea	1.81150351
16	MP0005646_abnormal_pituitary_gland	1.77561499
17	MP0002254_reproductive_system_inflammat	1.65906838
18	MP0004147_increased_porphyrin_level	1.65412864
19	MP0001346_abnormal_lacrimal_gland	1.64014028
20	MP0001756_abnormal_urination	1.58962703
21	MP0003786_premature_aging	1.58198287
22	MP0000685_abnormal_immune_system	1.58054993
23	MP0005332_abnormal_amino_acid	1.57862100
24	MP0003763_abnormal_thymus_physiology	1.57653736
25	MP0002876_abnormal_thyroid_physiology	1.54547703
26	MP0001986_abnormal_taste_sensitivity	1.50921570
27	MP0001853_heart_inflammation	1.48066389
28	MP0005551_abnormal_eye_electrophysiolog	1.46973700
29	MP0003172_abnormal_lysosome_physiology	1.45840544
30	MP0001905_abnormal_dopamine_level	1.45421041
31	MP0008875_abnormal_xenobiotic_pharmacok	1.44577117
32	MP0004043_abnormal_pH_regulation	1.41136686
33	MP0008872_abnormal_physiological_respon	1.38537700
34	MP0003137_abnormal_impulse_conducting	1.37836853
35	MP0006072_abnormal_retinal_apoptosis	1.36664464
36	MP0004145_abnormal_muscle_electrophysio	1.33983748
37	MP0009785_altered_susceptibility_to	1.31810965
38	MP0004885_abnormal_endolymph	1.29973376
39	MP0006036_abnormal_mitochondrial_physio	1.29283969
40	MP0001968_abnormal_touch/_nociception	1.26182107
41	MP0001661_extended_life_span	1.25411349
42	MP0009333_abnormal_splenocyte_physiolog	1.23980276
43	MP0002102_abnormal_ear_morphology	1.21258084
44	MP0002234_abnormal_pharynx_morphology	1.18664762
45	MP0003283_abnormal_digestive_organ	1.17331227
46	MP0003252_abnormal_bile_duct	1.16903285
47	MP0000613_abnormal_salivary_gland	1.16702322
48	MP0003011_delayed_dark_adaptation	1.16370601
49	MP0003866_abnormal_defecation	1.14668225
50	MP0002736_abnormal_nociception_after	1.14242712
51	MP0008961_abnormal_basal_metabolism	1.13870896
52	MP0000639_abnormal_adrenal_gland	1.08872878
53	MP0009643_abnormal_urine_homeostasis	1.08433160
54	MP0003195_calcinosis	1.07188681
55	MP0005075_abnormal_melanosome_morpholog	1.06563319
56	MP0001919_abnormal_reproductive_system	1.05276727
57	MP0005636_abnormal_mineral_homeostasis	1.03487580
58	MP0002693_abnormal_pancreas_physiology	1.03478500
59	MP0003186_abnormal_redox_activity	1.03172883
60	MP0005377_hearing/vestibular/ear_phenot	1.01991787
61	MP0003878_abnormal_ear_physiology	1.01991787
62	MP0005000_abnormal_immune_tolerance	0.99659326
63	MP0002877_abnormal_melanocyte_morpholog	0.99335392
64	MP0005389_reproductive_system_phenotype	0.99312086
65	MP0005085_abnormal_gallbladder_physiolo	0.97207686
66	MP0005645_abnormal_hypothalamus_physiol	0.95894850
67	MP0003693_abnormal_embryo_hatching	0.93987955
68	MP0005310_abnormal_salivary_gland	0.93286669
69	MP0008058_abnormal_DNA_repair	0.93275321
70	MP0001348_abnormal_lacrimal_gland	0.92273582
71	MP0003941_abnormal_skin_development	0.90735160
72	MP0010307_abnormal_tumor_latency	0.90368949
73	MP0000013_abnormal_adipose_tissue	0.89840281
74	MP0006035_abnormal_mitochondrial_morpho	0.88901446
75	MP0005083_abnormal_biliary_tract	0.88818700
76	MP0002420_abnormal_adaptive_immunity	0.88334447
77	MP0002909_abnormal_adrenal_gland	0.87496690
78	MP0001819_abnormal_immune_cell	0.87401730
79	MP0001845_abnormal_inflammatory_respons	0.87385671
80	MP0002837_dystrophic_cardiac_calcinosis	0.87332539
81	MP0001765_abnormal_ion_homeostasis	0.87232521
82	MP0005174_abnormal_tail_pigmentation	0.87001275
83	MP0001664_abnormal_digestion	0.86624822
84	MP0002723_abnormal_immune_serum	0.85505802
85	MP0002166_altered_tumor_susceptibility	0.85470271
86	MP0002139_abnormal_hepatobiliary_system	0.83911894
87	MP0003303_peritoneal_inflammation	0.83397827
88	MP0002938_white_spotting	0.82951083
89	MP0002006_tumorigenesis	0.82423247
90	MP0001944_abnormal_pancreas_morphology	0.81228090
91	MP0001800_abnormal_humoral_immune	0.78096018
92	MP0002398_abnormal_bone_marrow	0.77936098
93	MP0000689_abnormal_spleen_morphology	0.74674104
94	MP0000470_abnormal_stomach_morphology	0.74102771
95	MP0008873_increased_physiological_sensi	0.72357776
96	MP0009745_abnormal_behavioral_response	0.72278559
97	MP0004957_abnormal_blastocyst_morpholog	0.72050143
98	MP0003950_abnormal_plasma_membrane	0.71943274
99	MP0002090_abnormal_vision	0.70293145
100	MP0005025_abnormal_response_to	0.69421183

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Renal cortical cysts (HP:0000803)	4.64594424
2	Type I transferrin isoform profile (HP:0003642)	4.52712380
3	Congenital, generalized hypertrichosis (HP:0004540)	4.33924095
4	Generalized aminoaciduria (HP:0002909)	4.04099402
5	Acute necrotizing encephalopathy (HP:0006965)	3.53668182
6	Increased CSF lactate (HP:0002490)	3.53566890
7	Hypothermia (HP:0002045)	3.51512475
8	Acute encephalopathy (HP:0006846)	3.44165983
9	Hepatic necrosis (HP:0002605)	3.43915620
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.40893824
11	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.40893824
12	Tongue fasciculations (HP:0001308)	3.40665584
13	Progressive macrocephaly (HP:0004481)	3.28289257
14	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.22512306
15	Abnormal protein N-linked glycosylation (HP:0012347)	3.22512306
16	Abnormal protein glycosylation (HP:0012346)	3.22512306
17	Abnormal glycosylation (HP:0012345)	3.22512306
18	Mitochondrial inheritance (HP:0001427)	3.16098295
19	Reduced antithrombin III activity (HP:0001976)	3.09858915
20	Delayed CNS myelination (HP:0002188)	3.07509569
21	Elevated erythrocyte sedimentation rate (HP:0003565)	3.07028138
22	Abnormal mitochondria in muscle tissue (HP:0008316)	3.05519788
23	IgG deficiency (HP:0004315)	2.96238538
24	Cleft eyelid (HP:0000625)	2.95591425
25	Muscle fibrillation (HP:0010546)	2.93436453
26	Abnormality of the renal cortex (HP:0011035)	2.92217007
27	Thyroiditis (HP:0100646)	2.84453300
28	Progressive microcephaly (HP:0000253)	2.82444605
29	3-Methylglutaconic aciduria (HP:0003535)	2.78484708
30	Hepatocellular necrosis (HP:0001404)	2.71699914
31	T lymphocytopenia (HP:0005403)	2.71177356
32	Aplasia/hypoplasia of the uterus (HP:0008684)	2.70335639
33	Severe combined immunodeficiency (HP:0004430)	2.64785171
34	Disproportionate short-trunk short stature (HP:0003521)	2.64504285
35	Abnormality of T cell number (HP:0011839)	2.62808766
36	Hypoproteinemia (HP:0003075)	2.58856241
37	Hypoglycemic coma (HP:0001325)	2.54885732
38	Lower limb hyperreflexia (HP:0002395)	2.44311247
39	Ureteral obstruction (HP:0006000)	2.39158089
40	Abnormality of urine glucose concentration (HP:0011016)	2.34562338
41	Glycosuria (HP:0003076)	2.34562338
42	Arthropathy (HP:0003040)	2.34515147
43	Abnormality of magnesium homeostasis (HP:0004921)	2.31928572
44	Fair hair (HP:0002286)	2.25910144
45	Hypomagnesemia (HP:0002917)	2.24269512
46	Woolly hair (HP:0002224)	2.22844444
47	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.20032982
48	Renal Fanconi syndrome (HP:0001994)	2.19894610
49	Increased intramyocellular lipid droplets (HP:0012240)	2.19793549
50	Increased hepatocellular lipid droplets (HP:0006565)	2.17911830
51	Dicarboxylic aciduria (HP:0003215)	2.15984642
52	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.15984642
53	Abnormality of T cells (HP:0002843)	2.14592332
54	Lipid accumulation in hepatocytes (HP:0006561)	2.13793669
55	Severe muscular hypotonia (HP:0006829)	2.13687261
56	Cerebral edema (HP:0002181)	2.13576035
57	Porencephaly (HP:0002132)	2.11548516
58	Pulmonary fibrosis (HP:0002206)	2.08814336
59	Proximal tubulopathy (HP:0000114)	2.08355239
60	Hypoalbuminemia (HP:0003073)	2.07818758
61	Abnormal albumin level (HP:0012116)	2.07818758
62	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.06964081
63	Fibular aplasia (HP:0002990)	2.05454442
64	Optic disc pallor (HP:0000543)	2.05008738
65	Lactic acidosis (HP:0003128)	2.04792634
66	Congenital stationary night blindness (HP:0007642)	2.04605111
67	Ureteral stenosis (HP:0000071)	2.04429381
68	Abnormality of the pleura (HP:0002103)	2.01543457
69	Respiratory failure (HP:0002878)	2.00937346
70	Aplastic anemia (HP:0001915)	2.00058334
71	Lethargy (HP:0001254)	1.99978562
72	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.95859061
73	Abnormality of alanine metabolism (HP:0010916)	1.95859061
74	Hyperalaninemia (HP:0003348)	1.95859061
75	Facial diplegia (HP:0001349)	1.95468782
76	Hypergonadotropic hypogonadism (HP:0000815)	1.95432810
77	Abnormality of eosinophils (HP:0001879)	1.95377083
78	Combined immunodeficiency (HP:0005387)	1.92646503
79	CNS hypomyelination (HP:0003429)	1.92592923
80	Abnormality of secondary sexual hair (HP:0009888)	1.92538087
81	Abnormality of the axillary hair (HP:0100134)	1.92538087
82	Increased serum lactate (HP:0002151)	1.92394478
83	Increased muscle lipid content (HP:0009058)	1.91450608
84	Pigmentary retinal degeneration (HP:0001146)	1.91092449
85	Keratoconjunctivitis (HP:0001096)	1.91055993
86	Azoospermia (HP:0000027)	1.88934819
87	Degeneration of anterior horn cells (HP:0002398)	1.86652600
88	Abnormality of the anterior horn cell (HP:0006802)	1.86652600
89	Generalized hypopigmentation of hair (HP:0011358)	1.86172447
90	Dry hair (HP:0011359)	1.83908429
91	Autoimmune hemolytic anemia (HP:0001890)	1.81855826
92	Hyperinsulinemic hypoglycemia (HP:0000825)	1.81406601
93	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.81378595
94	Conjunctival hamartoma (HP:0100780)	1.79335371
95	Autoimmune thrombocytopenia (HP:0001973)	1.77630232
96	Pustule (HP:0200039)	1.77187231
97	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.74467217
98	Abnormality of polysaccharide metabolism (HP:0011012)	1.74467217
99	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.74467217
100	Eosinophilia (HP:0001880)	1.73950278

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.04942683
2	BMPR1B	5.29263272
3	MAP4K2	4.07795670
4	FRK	3.49920071
5	CDK8	3.12904590
6	KDR	3.06033495
7	ZAK	2.61279314
8	LIMK1	2.51862521
9	FLT3	2.51245786
10	TAOK3	2.43222449
11	SRPK1	2.39642248
12	PINK1	2.33968937
13	TLK1	2.31765577
14	TESK1	2.30384681
15	BUB1	2.23375597
16	ADRBK2	2.16977526
17	WNK4	2.09733766
18	MAP2K6	1.92224736
19	MAPKAPK3	1.74887844
20	GRK1	1.60030753
21	STK39	1.48237803
22	PHKG1	1.33602179
23	PHKG2	1.33602179
24	NEK1	1.06860242
25	TGFBR1	1.03100903
26	MATK	1.01646516
27	BMPR2	0.94199574
28	FGFR2	0.92316347
29	KIT	0.88051681
30	SCYL2	0.83193094
31	OXSR1	0.82309891
32	CAMKK2	0.82258835
33	ITK	0.81792901
34	PRKCI	0.77554340
35	CSF1R	0.76677979
36	PIM2	0.75379456
37	WEE1	0.73041871
38	PLK4	0.72982471
39	NLK	0.72972522
40	MET	0.72296829
41	TNK2	0.69994456
42	RIPK4	0.69988027
43	TESK2	0.66644673
44	PASK	0.66283829
45	PNCK	0.65558346
46	PKN2	0.64529467
47	CDK3	0.63278903
48	INSRR	0.62727338
49	SYK	0.61167268
50	TTK	0.60762688
51	PDK2	0.59309214
52	ERBB2	0.58975693
53	IRAK2	0.57941927
54	RPS6KA4	0.56147007
55	RPS6KA5	0.55762643
56	JAK3	0.55205288
57	IKBKB	0.55048465
58	PBK	0.54596066
59	LCK	0.54372088
60	NME2	0.53823252
61	TRPM7	0.53042091
62	CDK9	0.51560358
63	MAP4K1	0.51454810
64	MAP3K7	0.51297493
65	IRAK3	0.50843788
66	ADRBK1	0.49430847
67	PRKCQ	0.49146748
68	DAPK1	0.47637790
69	FES	0.47592110
70	CSNK1G1	0.46170094
71	NTRK1	0.45552690
72	MST4	0.44567660
73	LYN	0.43418421
74	MINK1	0.43390452
75	VRK2	0.43085668
76	IGF1R	0.39691130
77	GRK7	0.37300706
78	PKN1	0.37282738
79	CSNK1G3	0.37230202
80	VRK1	0.36338105
81	IKBKE	0.36244935
82	CDK7	0.34578076
83	ERN1	0.34064545
84	CSNK2A1	0.34027955
85	MAP3K14	0.30803696
86	ABL2	0.27058078
87	PLK3	0.26082846
88	CHUK	0.25839950
89	CAMKK1	0.25599732
90	ATR	0.25138073
91	PLK2	0.25018460
92	CSNK1A1	0.23720100
93	PRKG2	0.23061965
94	PLK1	0.22714919
95	FGFR3	0.21484924
96	PRKCA	0.21244146
97	CHEK2	0.19406949
98	WNK3	0.19085000
99	CSNK2A2	0.17764586
100	FYN	0.17749135

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.87424861
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.80579493
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.51280026
4	Parkinsons disease_Homo sapiens_hsa05012	3.04483563
5	RNA polymerase_Homo sapiens_hsa03020	2.86656834
6	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.70367484
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.42528552
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.23211125
9	Type I diabetes mellitus_Homo sapiens_hsa04940	2.18048802
10	One carbon pool by folate_Homo sapiens_hsa00670	2.16507818
11	Allograft rejection_Homo sapiens_hsa05330	2.15461615
12	Asthma_Homo sapiens_hsa05310	2.03541581
13	Base excision repair_Homo sapiens_hsa03410	1.97993116
14	Pyrimidine metabolism_Homo sapiens_hsa00240	1.97512275
15	DNA replication_Homo sapiens_hsa03030	1.92315629
16	Ribosome_Homo sapiens_hsa03010	1.85824266
17	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.82069126
18	Huntingtons disease_Homo sapiens_hsa05016	1.81564414
19	Alzheimers disease_Homo sapiens_hsa05010	1.79132499
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.78764047
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71218578
22	Selenocompound metabolism_Homo sapiens_hsa00450	1.68850602
23	Antigen processing and presentation_Homo sapiens_hsa04612	1.67223813
24	Rheumatoid arthritis_Homo sapiens_hsa05323	1.61369376
25	Protein export_Homo sapiens_hsa03060	1.59780949
26	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.57418425
27	Purine metabolism_Homo sapiens_hsa00230	1.55533459
28	Folate biosynthesis_Homo sapiens_hsa00790	1.50900954
29	Homologous recombination_Homo sapiens_hsa03440	1.49714032
30	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48944856
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.38217092
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.35295629
33	Fatty acid elongation_Homo sapiens_hsa00062	1.32924037
34	RNA degradation_Homo sapiens_hsa03018	1.28430522
35	Phototransduction_Homo sapiens_hsa04744	1.28047135
36	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.27284255
37	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.25343199
38	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.23855314
39	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.15333056
40	Tryptophan metabolism_Homo sapiens_hsa00380	1.09588661
41	Mismatch repair_Homo sapiens_hsa03430	1.08069542
42	Linoleic acid metabolism_Homo sapiens_hsa00591	0.97348678
43	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.95447282
44	Peroxisome_Homo sapiens_hsa04146	0.95053419
45	Propanoate metabolism_Homo sapiens_hsa00640	0.93398109
46	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.92616225
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.88744465
48	Collecting duct acid secretion_Homo sapiens_hsa04966	0.87999357
49	Butanoate metabolism_Homo sapiens_hsa00650	0.86120270
50	Fanconi anemia pathway_Homo sapiens_hsa03460	0.80413854
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.80185555
52	Basal transcription factors_Homo sapiens_hsa03022	0.79643448
53	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.78456010
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75361243
55	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.74896039
56	Caffeine metabolism_Homo sapiens_hsa00232	0.71596421
57	Metabolic pathways_Homo sapiens_hsa01100	0.71375919
58	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.71300322
59	Spliceosome_Homo sapiens_hsa03040	0.69765036
60	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.68767540
61	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.68487564
62	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.67558567
63	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63610953
64	Nucleotide excision repair_Homo sapiens_hsa03420	0.61862647
65	Olfactory transduction_Homo sapiens_hsa04740	0.60913155
66	Viral myocarditis_Homo sapiens_hsa05416	0.59708159
67	Ether lipid metabolism_Homo sapiens_hsa00565	0.59646326
68	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.58931398
69	Non-homologous end-joining_Homo sapiens_hsa03450	0.57726531
70	Nitrogen metabolism_Homo sapiens_hsa00910	0.57495822
71	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.55613559
72	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.54647639
73	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53150122
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.51079292
75	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.50328472
76	Salivary secretion_Homo sapiens_hsa04970	0.49404180
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49250095
78	Sulfur relay system_Homo sapiens_hsa04122	0.49095603
79	Regulation of autophagy_Homo sapiens_hsa04140	0.47328588
80	Chemical carcinogenesis_Homo sapiens_hsa05204	0.46872563
81	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38503346
82	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38376296
83	Renin-angiotensin system_Homo sapiens_hsa04614	0.36687741
84	Glutathione metabolism_Homo sapiens_hsa00480	0.36113850
85	RNA transport_Homo sapiens_hsa03013	0.35700092
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.35011705
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.33939315
88	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.32906914
89	Phenylalanine metabolism_Homo sapiens_hsa00360	0.28197402
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27764244
91	Herpes simplex infection_Homo sapiens_hsa05168	0.27233344
92	Mineral absorption_Homo sapiens_hsa04978	0.26584164
93	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.26463780
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.25090090
95	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.24826260
96	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.23639691
97	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.23107534
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.22223190
99	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.19120996
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.17658616

FAM136BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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