FAM13A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)7.00667538
2regulation of acrosome reaction (GO:0060046)6.74507569
3retinal cone cell development (GO:0046549)6.58465857
4regulation of DNA methylation (GO:0044030)6.44216775
5regulation of sequestering of triglyceride (GO:0010889)6.18703194
6biotin metabolic process (GO:0006768)5.86254165
7meiotic cell cycle (GO:0051321)5.75758773
8protein K11-linked deubiquitination (GO:0035871)5.53592859
9piRNA metabolic process (GO:0034587)5.50374183
10regulation of meiosis I (GO:0060631)5.48059396
11valine metabolic process (GO:0006573)5.29120798
12fatty acid transmembrane transport (GO:1902001)5.28440897
13low-density lipoprotein particle clearance (GO:0034383)5.23102918
14carnitine shuttle (GO:0006853)5.17721944
15triglyceride catabolic process (GO:0019433)4.75000697
16fatty acid beta-oxidation (GO:0006635)4.73023247
17oocyte development (GO:0048599)4.67716316
18cilium or flagellum-dependent cell motility (GO:0001539)4.66063923
19branched-chain amino acid catabolic process (GO:0009083)4.65699462
20alpha-linolenic acid metabolic process (GO:0036109)4.62794995
21brown fat cell differentiation (GO:0050873)4.55661408
22positive regulation of fatty acid oxidation (GO:0046321)4.54386898
23positive regulation of fatty acid beta-oxidation (GO:0032000)4.54123201
24multicellular organism reproduction (GO:0032504)4.53047443
25acylglycerol catabolic process (GO:0046464)4.50631730
26neutral lipid catabolic process (GO:0046461)4.50631730
27branched-chain amino acid metabolic process (GO:0009081)4.46533729
28interkinetic nuclear migration (GO:0022027)4.45429445
29DNA methylation involved in gamete generation (GO:0043046)4.38047794
30fatty acid oxidation (GO:0019395)4.31599232
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.30869547
32carnitine transmembrane transport (GO:1902603)4.29764623
33acetyl-CoA metabolic process (GO:0006084)4.29581486
34lipid oxidation (GO:0034440)4.26159216
35fatty acid catabolic process (GO:0009062)4.20308157
36amino-acid betaine transport (GO:0015838)4.17148871
37carnitine transport (GO:0015879)4.17148871
38regulation of triglyceride catabolic process (GO:0010896)4.13221027
39regulation of fatty acid oxidation (GO:0046320)4.12967020
40short-chain fatty acid metabolic process (GO:0046459)4.11614189
41regulation of steroid hormone biosynthetic process (GO:0090030)4.05102989
42negative regulation of reproductive process (GO:2000242)4.02718682
43lysine catabolic process (GO:0006554)3.97789093
44lysine metabolic process (GO:0006553)3.97789093
45thioester biosynthetic process (GO:0035384)3.94895828
46acyl-CoA biosynthetic process (GO:0071616)3.94895828
47L-amino acid import (GO:0043092)3.93973002
48white fat cell differentiation (GO:0050872)3.88470536
49NADH metabolic process (GO:0006734)3.85793831
50triglyceride biosynthetic process (GO:0019432)3.84891684
51female gamete generation (GO:0007292)3.80412411
52acylglycerol biosynthetic process (GO:0046463)3.79677659
53neutral lipid biosynthetic process (GO:0046460)3.79677659
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.79632656
55positive regulation of lipid catabolic process (GO:0050996)3.75800847
56negative regulation of hormone biosynthetic process (GO:0032353)3.75195052
57regulation of histone H3-K9 methylation (GO:0051570)3.74186421
58complement activation, alternative pathway (GO:0006957)3.73818797
59glycine transport (GO:0015816)3.73788510
60regulation of fatty acid beta-oxidation (GO:0031998)3.71815418
61fatty-acyl-CoA biosynthetic process (GO:0046949)3.71646476
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69275016
63negative regulation of hormone metabolic process (GO:0032351)3.65188294
64tricarboxylic acid cycle (GO:0006099)3.64586725
65monocarboxylic acid catabolic process (GO:0072329)3.62795005
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.61045601
67L-phenylalanine catabolic process (GO:0006559)3.61045601
682-oxoglutarate metabolic process (GO:0006103)3.59550404
69sulfur amino acid catabolic process (GO:0000098)3.58334267
70centriole replication (GO:0007099)3.56288550
71plasma lipoprotein particle clearance (GO:0034381)3.55226326
72negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.55135048
73regulation of cholesterol storage (GO:0010885)3.54980434
74quaternary ammonium group transport (GO:0015697)3.50079369
75L-phenylalanine metabolic process (GO:0006558)3.49987675
76erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.49987675
77amino-acid betaine metabolic process (GO:0006577)3.49510155
78protein kinase C signaling (GO:0070528)3.49216252
79carnitine metabolic process (GO:0009437)3.47390899
80gene silencing by RNA (GO:0031047)3.45592524
81fatty-acyl-CoA metabolic process (GO:0035337)3.45348215
82succinate metabolic process (GO:0006105)3.44841666
83tricarboxylic acid metabolic process (GO:0072350)3.44305273
84regulation of steroid hormone secretion (GO:2000831)3.43410977
85triglyceride metabolic process (GO:0006641)3.42661897
86triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.42226650
87positive regulation of fatty acid metabolic process (GO:0045923)3.36951802
88triglyceride homeostasis (GO:0070328)3.36527408
89acylglycerol homeostasis (GO:0055090)3.36527408
90regulation of triglyceride metabolic process (GO:0090207)3.35777469
91long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.32415378
92glycerolipid catabolic process (GO:0046503)3.32304496
93negative regulation of histone methylation (GO:0031061)3.31800315
94cilium movement (GO:0003341)3.31694465
95regulation of calcium ion-dependent exocytosis (GO:0017158)3.29683715
96genitalia morphogenesis (GO:0035112)3.29071009
97acylglycerol metabolic process (GO:0006639)3.27435581
98regulation of triglyceride biosynthetic process (GO:0010866)3.26533460
99polyol transport (GO:0015791)3.26296251
100neutral lipid metabolic process (GO:0006638)3.23928040
101regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.20920091
102cysteine metabolic process (GO:0006534)3.20809902
103coenzyme A biosynthetic process (GO:0015937)3.19925645
104labyrinthine layer development (GO:0060711)3.18848240
105regulation of cell maturation (GO:1903429)3.18491532
106citrulline biosynthetic process (GO:0019240)3.18043921
107intracellular lipid transport (GO:0032365)3.17547943
108positive regulation of triglyceride metabolic process (GO:0090208)3.16419694
109phosphorelay signal transduction system (GO:0000160)3.15818277
110lipid particle organization (GO:0034389)3.13806793
111acyl-CoA metabolic process (GO:0006637)3.13695223
112thioester metabolic process (GO:0035383)3.13695223
113long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.10770995
114presynaptic membrane assembly (GO:0097105)3.09176087
115fatty acid homeostasis (GO:0055089)3.09067778
116cAMP catabolic process (GO:0006198)3.07609262
117ethanol oxidation (GO:0006069)3.05083331
118transcytosis (GO:0045056)3.03808462
119epithelial cilium movement (GO:0003351)3.03769525
120negative regulation of circadian rhythm (GO:0042754)3.01040628
121cellular ketone body metabolic process (GO:0046950)3.00244238
122lipid storage (GO:0019915)2.99539883
123positive regulation of lipid storage (GO:0010884)2.97847462
124homocysteine metabolic process (GO:0050667)2.97713776
125reproduction (GO:0000003)2.97292432
126positive regulation of gastrulation (GO:2000543)2.97261119
127regulation of acyl-CoA biosynthetic process (GO:0050812)2.97138305
128positive regulation of reproductive process (GO:2000243)2.96770700
129positive regulation of osteoblast proliferation (GO:0033690)2.95896356
130negative regulation of lipase activity (GO:0060192)2.95488871
131positive regulation of histone H3-K4 methylation (GO:0051571)2.94912064
132carboxylic acid catabolic process (GO:0046395)2.94345292
133organic acid catabolic process (GO:0016054)2.94345292
134oxaloacetate metabolic process (GO:0006107)2.94036723
135phospholipid homeostasis (GO:0055091)2.92922995
136N-terminal protein amino acid acetylation (GO:0006474)2.92227676
137urea metabolic process (GO:0019627)2.92146024
138urea cycle (GO:0000050)2.92146024
139linoleic acid metabolic process (GO:0043651)2.85147456
140negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.83891428
141long-chain fatty acid transport (GO:0015909)2.83201923
142aromatic amino acid family catabolic process (GO:0009074)2.83062994
143positive regulation of respiratory burst (GO:0060267)2.82912339
144coenzyme A metabolic process (GO:0015936)2.80892313
145regulation of macrophage derived foam cell differentiation (GO:0010743)2.79311314
146regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.78358051
147regulation of lipid catabolic process (GO:0050994)2.77599674
148cyclic nucleotide catabolic process (GO:0009214)2.76963944
149positive regulation of humoral immune response (GO:0002922)2.68628206
150histone H3-K9 demethylation (GO:0033169)2.67731704
151primitive streak formation (GO:0090009)2.67595557
152interleukin-6-mediated signaling pathway (GO:0070102)2.66788256
153relaxation of smooth muscle (GO:0044557)2.66009534
154negative regulation of cAMP-mediated signaling (GO:0043951)2.64274345
155relaxation of cardiac muscle (GO:0055119)2.62777463
156regulation of reproductive process (GO:2000241)2.61591605
157presynaptic membrane organization (GO:0097090)2.61427548
158positive regulation of meiosis (GO:0045836)2.59424219
159nucleus localization (GO:0051647)2.58426960
160neuron fate determination (GO:0048664)2.58277383
161cochlea development (GO:0090102)2.57348269
162righting reflex (GO:0060013)2.56341844
163negative regulation of translation, ncRNA-mediated (GO:0040033)2.55249443
164regulation of translation, ncRNA-mediated (GO:0045974)2.55249443
165negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.55249443
166regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54230012
167amino acid import (GO:0043090)2.54222567
168axonemal dynein complex assembly (GO:0070286)2.52096359
169centriole assembly (GO:0098534)2.50423352
170positive regulation of mitotic sister chromatid separation (GO:1901970)2.48474798
171positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.48474798
172positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.48474798
173fertilization (GO:0009566)2.46208940
174synapsis (GO:0007129)2.40825144
175eye photoreceptor cell development (GO:0042462)2.40637112
176oogenesis (GO:0048477)2.39711013
177positive regulation of meiotic cell cycle (GO:0051446)2.39444562
178phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.37549534
179regulation of lipoprotein metabolic process (GO:0050746)2.36563280
180phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36110735
181diterpenoid biosynthetic process (GO:0016102)2.35847759
182protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.35620370
183DNA methylation (GO:0006306)2.34766773
184DNA alkylation (GO:0006305)2.34766773
185cerebral cortex radially oriented cell migration (GO:0021799)2.33587156
186myelination in peripheral nervous system (GO:0022011)2.32617111
187peripheral nervous system axon ensheathment (GO:0032292)2.32617111
188photoreceptor cell maintenance (GO:0045494)2.31378023
189regulation of hormone biosynthetic process (GO:0046885)2.31145809
190sodium ion homeostasis (GO:0055078)2.29689912
191centrosome localization (GO:0051642)2.28287518
192regulation of meiosis (GO:0040020)2.27855434
193lymphangiogenesis (GO:0001946)2.27787755
194positive regulation of microtubule polymerization (GO:0031116)2.27403860
195sulfation (GO:0051923)2.26580347
196positive regulation of male gonad development (GO:2000020)2.25933449
197male meiosis (GO:0007140)2.24353139
198omega-hydroxylase P450 pathway (GO:0097267)2.22445065
199gene silencing (GO:0016458)2.21177714

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse9.11724912
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.40799573
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.19096711
4TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.89465798
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.67084678
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.57979594
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.29312233
8CLOCK_20551151_ChIP-Seq_293T_Human2.94750300
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.80781070
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.59632923
11CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43650561
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37129234
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.22639162
14SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.16497005
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15952714
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.05541924
17ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95911772
18SMAD4_21799915_ChIP-Seq_A2780_Human1.89265992
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85885683
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.85760951
21POU3F2_20337985_ChIP-ChIP_501MEL_Human1.85169307
22SALL1_21062744_ChIP-ChIP_HESCs_Human1.77692438
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77643561
24P300_19829295_ChIP-Seq_ESCs_Human1.70996980
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.70270082
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68590157
27TOP2B_26459242_ChIP-Seq_MCF-7_Human1.67412642
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.67200902
29TP53_16413492_ChIP-PET_HCT116_Human1.66545713
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63382014
31UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.62567521
32* TCF4_23295773_ChIP-Seq_U87_Human1.62497275
33* STAT3_23295773_ChIP-Seq_U87_Human1.61004758
34CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59987007
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.59851541
36CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59564605
37PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.59365202
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57225379
39TAF15_26573619_Chip-Seq_HEK293_Human1.57107035
40FUS_26573619_Chip-Seq_HEK293_Human1.56711257
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.56146160
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.54501815
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53736860
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.51082226
45VDR_22108803_ChIP-Seq_LS180_Human1.49017768
46* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.46535302
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46109636
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45212486
49AR_21572438_ChIP-Seq_LNCaP_Human1.43476079
50BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.42899257
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41500940
52CBP_20019798_ChIP-Seq_JUKART_Human1.41500940
53POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40931832
54TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40931832
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39054985
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.38245615
57EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37254840
58RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37254840
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36344116
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34502002
61* RUNX2_22187159_ChIP-Seq_PCA_Human1.33466832
62FOXA2_19822575_ChIP-Seq_HepG2_Human1.29947116
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.29187333
64TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28535149
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28333545
66ESR1_21235772_ChIP-Seq_MCF-7_Human1.28160042
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26977252
68EWS_26573619_Chip-Seq_HEK293_Human1.26817038
69LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26764587
70STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.26747505
71STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.25721125
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.25628691
73SMAD4_21741376_ChIP-Seq_EPCs_Human1.24996444
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.24844644
75* PRDM14_20953172_ChIP-Seq_ESCs_Human1.24715815
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.23433131
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22257025
78TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.22084917
79ER_23166858_ChIP-Seq_MCF-7_Human1.22031735
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.22000930
81SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.20488469
82CDX2_22108803_ChIP-Seq_LS180_Human1.19611418
83ZNF263_19887448_ChIP-Seq_K562_Human1.19278147
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17957331
85ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16537015
86GBX2_23144817_ChIP-Seq_PC3_Human1.15614234
87KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.13975793
88KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.13975793
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.13975793
90STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13682004
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.12846338
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12778464
93BCAT_22108803_ChIP-Seq_LS180_Human1.12519454
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11565153
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11521363
96DROSHA_22980978_ChIP-Seq_HELA_Human1.11204634
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10341818
98SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10098537
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.10058820
100TP53_18474530_ChIP-ChIP_U2OS_Human1.10020651
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.09180789
102TBX20_22328084_ChIP-Seq_HEART_Mouse1.09180789
103NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08397072
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08397072
105EZH2_22144423_ChIP-Seq_EOC_Human1.08221371
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.06366868
107EED_16625203_ChIP-ChIP_MESCs_Mouse1.05749726
108SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04941812
109SMAD3_21741376_ChIP-Seq_HESCs_Human1.03814066
110SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03427954
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02674162
112* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.01648700
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01450232
114CDX2_20551321_ChIP-Seq_CACO-2_Human1.01284023
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.99424840
116GATA1_22025678_ChIP-Seq_K562_Human0.98697870
117CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98661522
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.98587406
119* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98552140
120TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98454297
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.98087995
122* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98041798
123TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.97859388
124ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97172248
125FOXO3_23340844_ChIP-Seq_DLD1_Human0.96807172
126SOX2_20726797_ChIP-Seq_SW620_Human0.96600009
127CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96149357
128AR_19668381_ChIP-Seq_PC3_Human0.95231873
129RXR_22108803_ChIP-Seq_LS180_Human0.94290506
130TP63_23658742_ChIP-Seq_EP156T_Human0.93950428
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90131458
132JARID2_20075857_ChIP-Seq_MESCs_Mouse0.89012969
133ERG_21242973_ChIP-ChIP_JURKAT_Human0.87604792
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86939114
135HNF4A_19822575_ChIP-Seq_HepG2_Human0.86236034
136GATA2_21666600_ChIP-Seq_HMVEC_Human0.86129124
137* CJUN_26792858_Chip-Seq_BT549_Human0.83020430
138GATA4_25053715_ChIP-Seq_YYC3_Human0.82918402
139* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82656182
140AHR_22903824_ChIP-Seq_MCF-7_Human0.81624567
141NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81497768
142* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.79407284
143* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77742659
144ARNT_22903824_ChIP-Seq_MCF-7_Human0.75011129
145PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.72431730
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.71321373
147Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.71241779
148* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.70835071
149SALL4_18804426_ChIP-ChIP_XEN_Mouse0.70825836
150JARID2_20064375_ChIP-Seq_MESCs_Mouse0.70656543
151* AR_25329375_ChIP-Seq_VCAP_Human0.69926949
152* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.69478178
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.68826562
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.68790025
155SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.68277479
156TCF4_22108803_ChIP-Seq_LS180_Human0.68227839
157* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.68072184
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.67170042
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.66778485
160* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.66121807
161KLF4_19829295_ChIP-Seq_ESCs_Human0.65962081
162TCF4_18268006_ChIP-ChIP_LS174T_Human0.65640398
163ISL1_27105846_Chip-Seq_CPCs_Mouse0.65268442
164EZH2_27294783_Chip-Seq_ESCs_Mouse0.65136550
165PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.63646579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose5.68668378
2MP0003718_maternal_effect5.29601606
3MP0002139_abnormal_hepatobiliary_system4.35588241
4MP0005360_urolithiasis4.18293990
5MP0004130_abnormal_muscle_cell3.79181538
6MP0005666_abnormal_adipose_tissue3.75260033
7MP0005365_abnormal_bile_salt3.59748166
8MP0010329_abnormal_lipoprotein_level3.28999160
9MP0008789_abnormal_olfactory_epithelium3.03520962
10MP0008875_abnormal_xenobiotic_pharmacok3.00103484
11MP0002837_dystrophic_cardiac_calcinosis2.98642234
12MP0005085_abnormal_gallbladder_physiolo2.97610278
13MP0004185_abnormal_adipocyte_glucose2.92713693
14MP0003183_abnormal_peptide_metabolism2.92369470
15MP0000566_synostosis2.77297535
16MP0006292_abnormal_olfactory_placode2.73535207
17MP0005375_adipose_tissue_phenotype2.62498840
18MP0003890_abnormal_embryonic-extraembry2.59851541
19MP0008438_abnormal_cutaneous_collagen2.58697617
20MP0008877_abnormal_DNA_methylation2.57741451
21MP0002971_abnormal_brown_adipose2.56903379
22MP0005395_other_phenotype2.50108464
23MP0005394_taste/olfaction_phenotype2.42493060
24MP0005499_abnormal_olfactory_system2.42493060
25MP0002876_abnormal_thyroid_physiology2.33168873
26MP0002118_abnormal_lipid_homeostasis2.30527973
27MP0003252_abnormal_bile_duct2.24923798
28MP0000013_abnormal_adipose_tissue2.24111508
29MP0001984_abnormal_olfaction2.23508189
30MP0005332_abnormal_amino_acid2.22717066
31MP0002254_reproductive_system_inflammat2.19809779
32MP0003950_abnormal_plasma_membrane2.10180919
33MP0003879_abnormal_hair_cell1.98355123
34MP0003191_abnormal_cellular_cholesterol1.98272364
35MP0005187_abnormal_penis_morphology1.92191988
36MP0010030_abnormal_orbit_morphology1.89508286
37MP0005334_abnormal_fat_pad1.86876991
38MP0001661_extended_life_span1.83938069
39MP0000003_abnormal_adipose_tissue1.82060644
40MP0000383_abnormal_hair_follicle1.81258523
41MP0003868_abnormal_feces_composition1.79135965
42MP0005551_abnormal_eye_electrophysiolog1.76048596
43MP0010678_abnormal_skin_adnexa1.74654688
44MP0005535_abnormal_body_temperature1.74484576
45MP0001881_abnormal_mammary_gland1.73177895
46MP0009115_abnormal_fat_cell1.69459879
47MP0001666_abnormal_nutrient_absorption1.67636809
48MP0004019_abnormal_vitamin_homeostasis1.66214509
49MP0010368_abnormal_lymphatic_system1.65382963
50MP0000609_abnormal_liver_physiology1.60347543
51MP0003699_abnormal_female_reproductive1.59423322
52MP0005584_abnormal_enzyme/coenzyme_acti1.56704362
53MP0008057_abnormal_DNA_replication1.52632184
54MP0000631_abnormal_neuroendocrine_gland1.47153014
55MP0005083_abnormal_biliary_tract1.44564201
56MP0005248_abnormal_Harderian_gland1.42426989
57MP0004272_abnormal_basement_membrane1.41951988
58MP0002234_abnormal_pharynx_morphology1.41788649
59MP0005275_abnormal_skin_tensile1.39656490
60MP0006276_abnormal_autonomic_nervous1.37109993
61MP0009643_abnormal_urine_homeostasis1.36347163
62MP0001929_abnormal_gametogenesis1.35019379
63MP0003136_yellow_coat_color1.34458021
64MP0005448_abnormal_energy_balance1.33664294
65MP0003329_amyloid_beta_deposits1.33611293
66MP0001486_abnormal_startle_reflex1.32947892
67MP0002970_abnormal_white_adipose1.30822218
68MP0002233_abnormal_nose_morphology1.28743662
69MP0003705_abnormal_hypodermis_morpholog1.27723607
70MP0000427_abnormal_hair_cycle1.27228977
71MP0001324_abnormal_eye_pigmentation1.26830435
72MP0005319_abnormal_enzyme/_coenzyme1.26627235
73MP0006036_abnormal_mitochondrial_physio1.26238230
74MP0005646_abnormal_pituitary_gland1.25477986
75MP0002078_abnormal_glucose_homeostasis1.24768660
76MP0003690_abnormal_glial_cell1.19809756
77MP0004270_analgesia1.19788860
78MP0002272_abnormal_nervous_system1.19436496
79MP0000604_amyloidosis1.19419508
80MP0000569_abnormal_digit_pigmentation1.18320858
81MP0005377_hearing/vestibular/ear_phenot1.16697525
82MP0003878_abnormal_ear_physiology1.16697525
83MP0009780_abnormal_chondrocyte_physiolo1.15847548
84MP0003646_muscle_fatigue1.15051349
85MP0002210_abnormal_sex_determination1.12191732
86MP0004043_abnormal_pH_regulation1.11470632
87MP0000653_abnormal_sex_gland1.09813237
88MP0000751_myopathy1.08763417
89MP0005647_abnormal_sex_gland1.08064913
90MP0001756_abnormal_urination1.08033935
91MP0002638_abnormal_pupillary_reflex1.04891732
92MP0003959_abnormal_lean_body1.03816860
93MP0003195_calcinosis1.00009512
94MP0005389_reproductive_system_phenotype0.98108628
95MP0004215_abnormal_myocardial_fiber0.96954433
96MP0006138_congestive_heart_failure0.96873691
97MP0003186_abnormal_redox_activity0.96312783
98MP0001501_abnormal_sleep_pattern0.95550320
99MP0002161_abnormal_fertility/fecundity0.95421954
100MP0001502_abnormal_circadian_rhythm0.95342293
101MP0005253_abnormal_eye_physiology0.95050968
102MP0001293_anophthalmia0.94378503
103MP0005636_abnormal_mineral_homeostasis0.94079279
104MP0001765_abnormal_ion_homeostasis0.93027900
105MP0005167_abnormal_blood-brain_barrier0.91474254
106MP0000230_abnormal_systemic_arterial0.91078359
107MP0008004_abnormal_stomach_pH0.89690873
108MP0001764_abnormal_homeostasis0.89501438
109MP0002160_abnormal_reproductive_system0.88320841
110MP0005620_abnormal_muscle_contractility0.87962929
111MP0003953_abnormal_hormone_level0.87693022
112MP0010234_abnormal_vibrissa_follicle0.87664559
113MP0005330_cardiomyopathy0.87233100
114MP0002796_impaired_skin_barrier0.85915610
115MP0000681_abnormal_thyroid_gland0.85839388
116MP0005452_abnormal_adipose_tissue0.85492290
117MP0003698_abnormal_male_reproductive0.85372773
118MP0003806_abnormal_nucleotide_metabolis0.84972109
119MP0003045_fibrosis0.84906684
120MP0002168_other_aberrant_phenotype0.84881467
121MP0008961_abnormal_basal_metabolism0.83281236
122MP0001177_atelectasis0.82406269
123MP0003119_abnormal_digestive_system0.81364319
124MP0003656_abnormal_erythrocyte_physiolo0.80090790
125MP0008775_abnormal_heart_ventricle0.79286058
126MP0002734_abnormal_mechanical_nocicepti0.78817233
127MP0009840_abnormal_foam_cell0.78396490
128MP0005164_abnormal_response_to0.76009365
129MP0001664_abnormal_digestion0.75715142
130MP0003880_abnormal_central_pattern0.75381382
131MP0001544_abnormal_cardiovascular_syste0.75085636
132MP0005385_cardiovascular_system_phenoty0.75085636
133MP0005195_abnormal_posterior_eye0.74916199
134MP0004087_abnormal_muscle_fiber0.74388138
135MP0005409_darkened_coat_color0.74210360
136MP0004147_increased_porphyrin_level0.73026431
137MP0003935_abnormal_craniofacial_develop0.72984301
138MP0001119_abnormal_female_reproductive0.72820623
139MP0004484_altered_response_of0.72454966
140MP0000762_abnormal_tongue_morphology0.71246557
141MP0000647_abnormal_sebaceous_gland0.69898909
142MP0002735_abnormal_chemical_nociception0.69832650
143MP0002972_abnormal_cardiac_muscle0.69439080
144MP0001145_abnormal_male_reproductive0.69038876
145MP0001485_abnormal_pinna_reflex0.68526414
146MP0002332_abnormal_exercise_endurance0.67539597
147MP0000678_abnormal_parathyroid_gland0.67383616
148MP0001963_abnormal_hearing_physiology0.66228546
149MP0004924_abnormal_behavior0.65877498
150MP0005386_behavior/neurological_phenoty0.65877498
151MP0002909_abnormal_adrenal_gland0.65821863
152MP0003011_delayed_dark_adaptation0.64698875
153MP0000778_abnormal_nervous_system0.64393942
154MP0001879_abnormal_lymphatic_vessel0.64243770
155MP0004036_abnormal_muscle_relaxation0.62096358
156MP0002060_abnormal_skin_morphology0.61977888
157MP0002108_abnormal_muscle_morphology0.61946422
158MP0004883_abnormal_blood_vessel0.60978767
159MP0002136_abnormal_kidney_physiology0.60818497
160MP0009642_abnormal_blood_homeostasis0.60366875
161MP0003724_increased_susceptibility_to0.59526457
162MP0001958_emphysema0.57190246
163MP0005376_homeostasis/metabolism_phenot0.56921808
164MP0003948_abnormal_gas_homeostasis0.55773243
165MP0002138_abnormal_hepatobiliary_system0.55415844
166MP0008872_abnormal_physiological_respon0.53829524
167MP0005595_abnormal_vascular_smooth0.53279905

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.06968565
2Abnormality of serine family amino acid metabolism (HP:0010894)5.25188152
3Abnormality of glycine metabolism (HP:0010895)5.25188152
4Papillary thyroid carcinoma (HP:0002895)4.79753548
5Oligomenorrhea (HP:0000876)4.79413140
6Hyperglycinemia (HP:0002154)4.30843585
7Congenital sensorineural hearing impairment (HP:0008527)4.30195829
8Ketosis (HP:0001946)4.28160469
9Hypoglycemic coma (HP:0001325)4.23247278
10Ketoacidosis (HP:0001993)4.20311919
11Decreased circulating renin level (HP:0003351)4.19939270
12Hyperammonemia (HP:0001987)4.19408075
13Abnormality of fatty-acid metabolism (HP:0004359)4.18331918
14Complement deficiency (HP:0004431)4.11424143
15Myoglobinuria (HP:0002913)3.78397842
16Hyperactive renin-angiotensin system (HP:0000841)3.77715118
17Abnormal ciliary motility (HP:0012262)3.77429572
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.74703894
19Absent/shortened dynein arms (HP:0200106)3.74703894
20Supernumerary spleens (HP:0009799)3.69989727
21Acanthosis nigricans (HP:0000956)3.66433797
22Osteomalacia (HP:0002749)3.63519863
23Hyperventilation (HP:0002883)3.56591745
24Xanthomatosis (HP:0000991)3.53108675
25Abnormality of dicarboxylic acid metabolism (HP:0010995)3.52746698
26Dicarboxylic aciduria (HP:0003215)3.52746698
27Hypoalphalipoproteinemia (HP:0003233)3.39989154
28Hypertriglyceridemia (HP:0002155)3.37159198
29Abnormality of proline metabolism (HP:0010907)3.36425476
30Hydroxyprolinuria (HP:0003080)3.36425476
31Abnormality of glutamine family amino acid metabolism (HP:0010902)3.34854307
32Hyperlipoproteinemia (HP:0010980)3.34506018
33Facial hemangioma (HP:0000329)3.34473132
34Impulsivity (HP:0100710)3.33164998
35Generalized aminoaciduria (HP:0002909)3.31321530
36Abnormal respiratory motile cilium physiology (HP:0012261)3.27361334
37Lip pit (HP:0100267)3.21891838
38Lower limb hyperreflexia (HP:0002395)3.18881597
39Epidermoid cyst (HP:0200040)3.13836717
40Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.10516794
41Deep venous thrombosis (HP:0002625)3.08521147
42Abnormality of the fovea (HP:0000493)3.05597908
43Fair hair (HP:0002286)3.00720828
44Abnormality of purine metabolism (HP:0004352)3.00631978
45Gonadotropin excess (HP:0000837)2.98956935
46Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.98250419
47Infertility (HP:0000789)2.93142581
48Increased muscle lipid content (HP:0009058)2.91863314
49Rhinitis (HP:0012384)2.91720718
50Hyperkalemia (HP:0002153)2.90131233
51Chronic hepatic failure (HP:0100626)2.88990777
52Anterior segment dysgenesis (HP:0007700)2.88350860
53Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.77653571
54Aplasia/Hypoplasia of the tongue (HP:0010295)2.75790993
55Abnormality of aromatic amino acid family metabolism (HP:0004338)2.73225032
56Intrahepatic cholestasis (HP:0001406)2.71482263
57Abnormal respiratory motile cilium morphology (HP:0005938)2.70904086
58Abnormal respiratory epithelium morphology (HP:0012253)2.70904086
59Rhabdomyolysis (HP:0003201)2.68622218
60Hypoplasia of the fovea (HP:0007750)2.67097622
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.67097622
62Hypolipoproteinemia (HP:0010981)2.65774503
63Aplasia/Hypoplasia of the tibia (HP:0005772)2.64729315
64Abnormality of complement system (HP:0005339)2.63495068
65Right ventricular cardiomyopathy (HP:0011663)2.63075584
66Lethargy (HP:0001254)2.62388137
67Thyroid-stimulating hormone excess (HP:0002925)2.60639389
68Nausea (HP:0002018)2.57736825
69Thyroid carcinoma (HP:0002890)2.56889125
70Hyperaldosteronism (HP:0000859)2.55803888
71Metabolic acidosis (HP:0001942)2.54893835
72Median cleft lip (HP:0000161)2.52388308
73Vomiting (HP:0002013)2.49281043
74Truncal obesity (HP:0001956)2.49080152
75Increased circulating renin level (HP:0000848)2.48372414
76Difficulty running (HP:0009046)2.46015444
77Tubulointerstitial nephritis (HP:0001970)2.45806145
78Oligodactyly (hands) (HP:0001180)2.44477751
79Skin nodule (HP:0200036)2.44210289
80Proximal tubulopathy (HP:0000114)2.43321820
81Abnormality of serum amino acid levels (HP:0003112)2.42944731
82Arterial tortuosity (HP:0005116)2.42914093
83Abnormality of renin-angiotensin system (HP:0000847)2.42515677
84Generalized hypopigmentation of hair (HP:0011358)2.42483258
85Capillary hemangiomas (HP:0005306)2.41821872
86Azoospermia (HP:0000027)2.41161756
87Chronic bronchitis (HP:0004469)2.40543566
88Increased purine levels (HP:0004368)2.40013953
89Hyperuricemia (HP:0002149)2.40013953
90Insulin-resistant diabetes mellitus (HP:0000831)2.39877783
91Aortic dissection (HP:0002647)2.38223230
92Pancreatitis (HP:0001733)2.37851747
93Stomach cancer (HP:0012126)2.35903673
94Gout (HP:0001997)2.34935792
95Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.32694429
96Male infertility (HP:0003251)2.32659648
97Cerebral edema (HP:0002181)2.27058785
98Hypoplastic labia majora (HP:0000059)2.25687141
99Hepatic necrosis (HP:0002605)2.25232332
100Abdominal situs inversus (HP:0003363)2.24781169
101Abnormality of abdominal situs (HP:0011620)2.24781169
102Hypercholesterolemia (HP:0003124)2.24045650
103Abnormal gallbladder physiology (HP:0012438)2.21939632
104Cholecystitis (HP:0001082)2.21939632
105Broad metatarsal (HP:0001783)2.19241858
106Pigmentary retinal degeneration (HP:0001146)2.18813620
107Pancreatic fibrosis (HP:0100732)2.18568754
108Bone cyst (HP:0012062)2.18056379
109Hemorrhage of the eye (HP:0011885)2.18003300
110Methylmalonic aciduria (HP:0012120)2.17753426
111Myocardial infarction (HP:0001658)2.17015181
112Short tibia (HP:0005736)2.15569012
113Vascular tortuosity (HP:0004948)2.14608518
114Insulin resistance (HP:0000855)2.10793666
115Pancreatic cysts (HP:0001737)2.10421765
116True hermaphroditism (HP:0010459)2.10020319
117Goiter (HP:0000853)2.09511168
118Hyperthyroidism (HP:0000836)2.08973813
119Thickened helices (HP:0000391)2.08897239
120Renal cortical cysts (HP:0000803)2.08509482
121Dysdiadochokinesis (HP:0002075)2.06770278
122Exercise-induced myalgia (HP:0003738)2.05096508
123Increased connective tissue (HP:0009025)2.04271645
124Hypophosphatemic rickets (HP:0004912)2.04239635
125Cerebral aneurysm (HP:0004944)2.03607820
126Gaze-evoked nystagmus (HP:0000640)2.02986136
127Abnormality of nucleobase metabolism (HP:0010932)2.02070384
128Abnormality of monocarboxylic acid metabolism (HP:0010996)2.01572756
129Prenatal maternal abnormality (HP:0002686)2.01297097
130Abnormality of the labia majora (HP:0012881)2.00913843
131Palpitations (HP:0001962)2.00704183
132Bile duct proliferation (HP:0001408)2.00388239
133Abnormal biliary tract physiology (HP:0012439)2.00388239
134Molar tooth sign on MRI (HP:0002419)2.00191974
135Abnormality of midbrain morphology (HP:0002418)2.00191974
136Septo-optic dysplasia (HP:0100842)1.99535136
137Tachypnea (HP:0002789)1.99434993
138Febrile seizures (HP:0002373)1.99095734
139Bilateral sensorineural hearing impairment (HP:0008619)1.98906968
140Cystic liver disease (HP:0006706)1.97065219
141Malnutrition (HP:0004395)1.94899288
142Muscle stiffness (HP:0003552)1.94654660
143Preaxial foot polydactyly (HP:0001841)1.93948133
144Delayed CNS myelination (HP:0002188)1.92939711
145Hyporeflexia of lower limbs (HP:0002600)1.92426187
146Abnormality of aspartate family amino acid metabolism (HP:0010899)1.90854276
147Ileus (HP:0002595)1.90800666
148Increased variability in muscle fiber diameter (HP:0003557)1.90797992
149Conjunctival hamartoma (HP:0100780)1.90396013
150Subacute progressive viral hepatitis (HP:0006572)1.90316374
151Type 1 muscle fiber predominance (HP:0003803)1.89483052
152Hypobetalipoproteinemia (HP:0003563)1.88732983
153Neoplasm of the oral cavity (HP:0100649)1.87763492
154Abnormal cartilage morphology (HP:0002763)1.86088338
155Long foot (HP:0001833)1.85827497
156Turricephaly (HP:0000262)1.84797979
157Biliary tract neoplasm (HP:0100574)1.84261831
158Metabolic alkalosis (HP:0200114)1.84207171
159Subcapsular cataract (HP:0000523)1.83564260
160Prolonged partial thromboplastin time (HP:0003645)1.82724190
161Bony spicule pigmentary retinopathy (HP:0007737)1.81910994
162Acute encephalopathy (HP:0006846)1.81698948
163Fat malabsorption (HP:0002630)1.79710044
164Hip contracture (HP:0003273)1.78649214
165Embryonal renal neoplasm (HP:0011794)1.77861036
166Growth hormone excess (HP:0000845)1.77513975
167Hyperglycemia (HP:0003074)1.76487022
168Hypoglycemic seizures (HP:0002173)1.76451429
169Systemic lupus erythematosus (HP:0002725)1.75931912
170Hyperpituitarism (HP:0010514)1.74442799
171Action tremor (HP:0002345)1.74331612
172Symptomatic seizures (HP:0011145)1.73867741
173Absent speech (HP:0001344)1.73416642
174Respiratory distress (HP:0002098)1.72973378
175Abnormality of the labia minora (HP:0012880)1.72286126
176Optic nerve hypoplasia (HP:0000609)1.70966427
177Striae distensae (HP:0001065)1.70402130
178Skin pits (HP:0100276)1.69366815
179Bronchiectasis (HP:0002110)1.68891200
180Tetraparesis (HP:0002273)1.68876367
181Nephritis (HP:0000123)1.68435483
182Nephroblastoma (Wilms tumor) (HP:0002667)1.67792344
183Tubulointerstitial abnormality (HP:0001969)1.66359728
184Accelerated skeletal maturation (HP:0005616)1.66285451
185Adrenal overactivity (HP:0002717)1.64981404
186Abnormality of potassium homeostasis (HP:0011042)1.62847914
187Steatorrhea (HP:0002570)1.62193469
188Progressive cerebellar ataxia (HP:0002073)1.61847824
189Aplasia/Hypoplasia of the macula (HP:0008059)1.61646233
190Oligodactyly (HP:0012165)1.61033151
191Megalencephaly (HP:0001355)1.60828403
192Volvulus (HP:0002580)1.60234913

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.67557583
2CAMK1D4.52634161
3TRIB33.80593054
4SIK13.79902615
5LMTK23.54378549
6CAMK1G3.48492132
7TNIK3.45990726
8PDK32.91895858
9PDK42.91895858
10MAP3K132.85049890
11ACVR1B2.67805794
12STK242.58138751
13AKT32.53359989
14NEK62.34723049
15RIPK12.23078463
16PDK22.18452365
17MAP3K92.08822711
18CASK2.01508169
19INSRR2.00779158
20MST1R1.93626099
21ERN11.88967039
22BRSK21.87770089
23NLK1.82857730
24FRK1.81246412
25EPHA41.77516788
26CDK121.73138481
27PRKAA21.71779985
28TAOK31.70390937
29ARAF1.66910918
30FGFR21.65836631
31MYLK1.65534469
32TGFBR21.63408769
33NTRK21.57545796
34MAPK131.54053680
35TTK1.50222719
36BMPR1B1.46647997
37PHKG21.41354054
38PHKG11.41354054
39PKN21.41082156
40DAPK21.37881185
41TIE11.27543281
42LATS11.23874305
43STK31.19400404
44MELK1.15113884
45WNK41.11991470
46PIK3CA1.11265891
47YES11.09543543
48TTN1.08883001
49FGFR41.08079503
50KSR11.06946504
51PDGFRA1.05204413
52TRPM71.03525553
53PRKAA10.97967424
54PDPK10.96022843
55MAP2K10.95889996
56MAP2K40.92844323
57MARK30.92455138
58EEF2K0.92413763
59MST40.91678043
60FER0.91064901
61STK380.91006005
62RAF10.90950848
63BRAF0.90096373
64MAPK150.89230265
65EPHB20.88632543
66TGFBR10.88375034
67BRD40.87739869
68CDK90.86671662
69MAP3K70.84566308
70OXSR10.81435252
71OBSCN0.80482987
72PRKG10.78105490
73FGFR30.77270418
74MOS0.76454295
75PTK60.75734722
76STK390.74880063
77STK38L0.74368711
78CSNK1G10.72534954
79PINK10.72463833
80MAPK120.72414422
81PIK3CG0.71048885
82PRKCH0.70918686
83SGK2230.70611404
84SGK4940.70611404
85MAP4K20.70406686
86JAK10.67685147
87PTK2B0.67558181
88PDK10.67469438
89EIF2AK30.67448204
90CAMK10.66717858
91CAMKK20.66212947
92MAPK110.64454180
93PRKACG0.64126283
94TNK20.63630394
95RET0.63508983
96NTRK30.62224165
97PAK30.62161037
98MET0.61816366
99MAPK70.61263394
100SGK30.60723710
101CDK50.60284155
102NEK90.59845732
103IRAK10.59138931
104PNCK0.58862596
105CDK60.58214304
106MAPKAPK30.57775339
107JAK20.53620417
108MAP3K20.53161282
109MARK10.52268166
110KSR20.51966915
111AURKA0.51851163
112PRKD10.50887109
113GSK3A0.50185232
114PRKG20.49795239
115IGF1R0.47043081
116CAMKK10.46844679
117* PRKCZ0.46680901
118NME10.46667463
119PRKCI0.46381766
120PKN10.45428987
121SGK20.45428540
122IRAK20.45355265
123PDGFRB0.44690971
124CAMK40.44553491
125EPHB10.43705952
126DDR20.42930434
127WNK10.42554600
128WNK30.42334036
129ATM0.41485190
130CSNK1D0.40735221
131MAPKAPK50.40705782
132LATS20.39551803
133PTK20.39266736
134PIM10.39053778
135CAMK2G0.37581296
136FGFR10.36619516
137PRKACB0.36502888
138PLK10.36328822
139GSK3B0.35928239
140CAMK2A0.35004621
141GRK50.34972129
142CSNK1E0.34571201
143IRAK30.34556438
144ROCK10.33126490
145MAP3K40.32922453
146DMPK0.32570813
147PRKACA0.31426689
148SGK10.31268733
149STK110.31144942
150SRC0.31120055
151PRKD30.30767419
152NUAK10.30239731
153ILK0.30142839
154INSR0.29125140
155MTOR0.27699478
156MAP3K60.26829272

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.96700532
2Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.49200767
3Fatty acid degradation_Homo sapiens_hsa000713.19543137
4Fatty acid biosynthesis_Homo sapiens_hsa000613.16925002
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.11519412
6PPAR signaling pathway_Homo sapiens_hsa033203.08871455
7Fatty acid metabolism_Homo sapiens_hsa012123.05715889
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.67613922
9Nitrogen metabolism_Homo sapiens_hsa009102.66555336
10Dorso-ventral axis formation_Homo sapiens_hsa043202.52972334
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.45572906
12Pyruvate metabolism_Homo sapiens_hsa006202.27718277
13Butanoate metabolism_Homo sapiens_hsa006502.17541423
14Circadian rhythm_Homo sapiens_hsa047102.14210361
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.95667394
16beta-Alanine metabolism_Homo sapiens_hsa004101.92814901
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.90249220
18Caffeine metabolism_Homo sapiens_hsa002321.89934528
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.89479046
20Tryptophan metabolism_Homo sapiens_hsa003801.84289051
21Glycerolipid metabolism_Homo sapiens_hsa005611.82046819
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.79387168
23Linoleic acid metabolism_Homo sapiens_hsa005911.77983314
24Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77780352
25Peroxisome_Homo sapiens_hsa041461.75583654
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72813853
27Carbon metabolism_Homo sapiens_hsa012001.71873142
28Arginine biosynthesis_Homo sapiens_hsa002201.70087772
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63984659
30Fat digestion and absorption_Homo sapiens_hsa049751.45587144
31Fatty acid elongation_Homo sapiens_hsa000621.44092593
32Basal transcription factors_Homo sapiens_hsa030221.43307730
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42928846
34Nicotine addiction_Homo sapiens_hsa050331.39318093
35Bile secretion_Homo sapiens_hsa049761.27883855
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.25622982
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.20380971
38Ether lipid metabolism_Homo sapiens_hsa005651.19769383
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.18263960
40Complement and coagulation cascades_Homo sapiens_hsa046101.17239397
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14984318
42Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.14098374
43Olfactory transduction_Homo sapiens_hsa047401.13914290
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13162399
45Inositol phosphate metabolism_Homo sapiens_hsa005621.11143330
46Adipocytokine signaling pathway_Homo sapiens_hsa049201.08270319
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.05454691
48Gap junction_Homo sapiens_hsa045401.02184821
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01837897
50Starch and sucrose metabolism_Homo sapiens_hsa005000.99194946
51Sulfur metabolism_Homo sapiens_hsa009200.98642331
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.98250081
53Phenylalanine metabolism_Homo sapiens_hsa003600.98008660
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95338113
55Tyrosine metabolism_Homo sapiens_hsa003500.95187800
56Morphine addiction_Homo sapiens_hsa050320.93199616
57Chemical carcinogenesis_Homo sapiens_hsa052040.92279501
58AMPK signaling pathway_Homo sapiens_hsa041520.91956968
59FoxO signaling pathway_Homo sapiens_hsa040680.90800620
60Serotonergic synapse_Homo sapiens_hsa047260.90437497
61Adherens junction_Homo sapiens_hsa045200.89971288
62Arachidonic acid metabolism_Homo sapiens_hsa005900.89785210
63Oocyte meiosis_Homo sapiens_hsa041140.89782293
64Phototransduction_Homo sapiens_hsa047440.87706827
65Long-term depression_Homo sapiens_hsa047300.85426502
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85387937
67Retinol metabolism_Homo sapiens_hsa008300.84863817
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84217817
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.83650176
70Cell cycle_Homo sapiens_hsa041100.82898279
71Histidine metabolism_Homo sapiens_hsa003400.81670048
72Staphylococcus aureus infection_Homo sapiens_hsa051500.81042978
73ABC transporters_Homo sapiens_hsa020100.80666672
74Biosynthesis of amino acids_Homo sapiens_hsa012300.75852959
75Glutamatergic synapse_Homo sapiens_hsa047240.75392992
76TGF-beta signaling pathway_Homo sapiens_hsa043500.74288913
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73448988
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73289657
79Insulin resistance_Homo sapiens_hsa049310.72348516
80Lysine degradation_Homo sapiens_hsa003100.71602414
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.69550032
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.69421893
83Glucagon signaling pathway_Homo sapiens_hsa049220.67941067
84Vitamin digestion and absorption_Homo sapiens_hsa049770.67123789
85Choline metabolism in cancer_Homo sapiens_hsa052310.64804566
86Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63557506
87Vitamin B6 metabolism_Homo sapiens_hsa007500.63415112
88Circadian entrainment_Homo sapiens_hsa047130.63220931
89Taste transduction_Homo sapiens_hsa047420.62949928
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61037448
91Insulin signaling pathway_Homo sapiens_hsa049100.59777753
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.55482518
93Cocaine addiction_Homo sapiens_hsa050300.55248646
94Amphetamine addiction_Homo sapiens_hsa050310.52250153
95Pentose phosphate pathway_Homo sapiens_hsa000300.52240579
96Calcium signaling pathway_Homo sapiens_hsa040200.52019484
97Endometrial cancer_Homo sapiens_hsa052130.51864635
98Thyroid hormone synthesis_Homo sapiens_hsa049180.51357344
99Cholinergic synapse_Homo sapiens_hsa047250.51260315
100GABAergic synapse_Homo sapiens_hsa047270.51138659
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.50984703
102Glutathione metabolism_Homo sapiens_hsa004800.49701131
103Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49507365
104Phospholipase D signaling pathway_Homo sapiens_hsa040720.49353102
105Renin secretion_Homo sapiens_hsa049240.48777677
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47542437
107mTOR signaling pathway_Homo sapiens_hsa041500.47484588
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.47075258
109Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46839423
110Oxytocin signaling pathway_Homo sapiens_hsa049210.44686865
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43996410
112Protein digestion and absorption_Homo sapiens_hsa049740.42770586
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42115086
114Ras signaling pathway_Homo sapiens_hsa040140.40188097
115Arginine and proline metabolism_Homo sapiens_hsa003300.39811955
116Dopaminergic synapse_Homo sapiens_hsa047280.38546996
117Salivary secretion_Homo sapiens_hsa049700.36348678
118Sulfur relay system_Homo sapiens_hsa041220.36033068
119Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35444924
120Metabolic pathways_Homo sapiens_hsa011000.35314492
121Galactose metabolism_Homo sapiens_hsa000520.35128107
122Gastric acid secretion_Homo sapiens_hsa049710.34645239
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.34533010
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.34259271
125Oxidative phosphorylation_Homo sapiens_hsa001900.33853666
126Steroid biosynthesis_Homo sapiens_hsa001000.32052034
127Ovarian steroidogenesis_Homo sapiens_hsa049130.30592464
128Type II diabetes mellitus_Homo sapiens_hsa049300.29366672
129Alzheimers disease_Homo sapiens_hsa050100.27686371
130Mineral absorption_Homo sapiens_hsa049780.26755692
131ECM-receptor interaction_Homo sapiens_hsa045120.26416858
132Fructose and mannose metabolism_Homo sapiens_hsa000510.25992863
133Folate biosynthesis_Homo sapiens_hsa007900.25355890
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22260067
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.21433147
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.19996913
137Dilated cardiomyopathy_Homo sapiens_hsa054140.19458182
138Selenocompound metabolism_Homo sapiens_hsa004500.19447886
139Cardiac muscle contraction_Homo sapiens_hsa042600.17698876
140Parkinsons disease_Homo sapiens_hsa050120.17236767
141cAMP signaling pathway_Homo sapiens_hsa040240.16198931
142Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.14634664
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.12995036
144cGMP-PKG signaling pathway_Homo sapiens_hsa040220.12809990
145Amoebiasis_Homo sapiens_hsa051460.12320636
146Pancreatic secretion_Homo sapiens_hsa049720.11488553
147Autoimmune thyroid disease_Homo sapiens_hsa053200.10648015

Most similar genes based on co-expression Upload to Enrichr

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