FAM13B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1macroautophagy (GO:0016236)4.03175153
2regulation of B cell receptor signaling pathway (GO:0050855)3.98014541
3cellular response to ethanol (GO:0071361)3.87523509
4NIK/NF-kappaB signaling (GO:0038061)3.83935290
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.74449943
6regulation of ARF protein signal transduction (GO:0032012)3.54254731
7cytoplasmic mRNA processing body assembly (GO:0033962)3.41040114
8cellular extravasation (GO:0045123)3.38736270
9nerve growth factor signaling pathway (GO:0038180)3.31596277
10B cell receptor signaling pathway (GO:0050853)3.31289979
11hepatocyte apoptotic process (GO:0097284)3.25408877
12positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.14780745
13detection of molecule of bacterial origin (GO:0032490)3.13663621
14establishment of protein localization to Golgi (GO:0072600)3.08868371
15histone H3-K36 demethylation (GO:0070544)3.06379326
16negative T cell selection (GO:0043383)3.05786482
17activated T cell proliferation (GO:0050798)3.01650651
18synaptic vesicle maturation (GO:0016188)2.99450199
19regulation of protein polyubiquitination (GO:1902914)2.98822268
20positive regulation by symbiont of host defense response (GO:0052509)2.90276220
21modulation by symbiont of host defense response (GO:0052031)2.90276220
22modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90276220
23modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90276220
24positive regulation by organism of defense response of other organism involved in symbiotic interact2.90276220
25modulation by symbiont of host immune response (GO:0052553)2.90276220
26retrograde transport, vesicle recycling within Golgi (GO:0000301)2.89471255
27protein targeting to Golgi (GO:0000042)2.87058636
28nuclear pore organization (GO:0006999)2.86822368
29sodium ion export (GO:0071436)2.86597112
30NLS-bearing protein import into nucleus (GO:0006607)2.83563807
31positive regulation of B cell differentiation (GO:0045579)2.82658158
32vesicle transport along microtubule (GO:0047496)2.80132211
33positive regulation of gamma-delta T cell activation (GO:0046645)2.79208609
34macrophage activation involved in immune response (GO:0002281)2.78032016
35regulation of clathrin-mediated endocytosis (GO:2000369)2.75986291
36acrosome assembly (GO:0001675)2.75499464
37glucocorticoid receptor signaling pathway (GO:0042921)2.71466941
38stress granule assembly (GO:0034063)2.70405259
39cell adhesion mediated by integrin (GO:0033627)2.69908239
40regulation of ARF GTPase activity (GO:0032312)2.69489835
41negative regulation of interleukin-12 production (GO:0032695)2.69217067
42clathrin coat assembly (GO:0048268)2.69123615
43production of molecular mediator involved in inflammatory response (GO:0002532)2.67149213
44negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.65936851
45negative regulation of cell killing (GO:0031342)2.65936851
46regulation of NFAT protein import into nucleus (GO:0051532)2.65804953
47cerebellar Purkinje cell differentiation (GO:0021702)2.65085504
48growth hormone receptor signaling pathway (GO:0060396)2.64081675
49necroptotic process (GO:0070266)2.63712011
50locomotory exploration behavior (GO:0035641)2.63124054
51monoubiquitinated protein deubiquitination (GO:0035520)2.60798920
52regulation of short-term neuronal synaptic plasticity (GO:0048172)2.60480866
53interkinetic nuclear migration (GO:0022027)2.58837263
54positive thymic T cell selection (GO:0045059)2.57508153
55negative regulation of neurotransmitter secretion (GO:0046929)2.56210832
56cytoskeletal anchoring at plasma membrane (GO:0007016)2.55963024
57positive regulation of fibroblast migration (GO:0010763)2.55485413
58corticosteroid receptor signaling pathway (GO:0031958)2.54682485
59regulation of nucleobase-containing compound transport (GO:0032239)2.53644222
60germinal center formation (GO:0002467)2.52830991
61synaptic vesicle docking involved in exocytosis (GO:0016081)2.51747925
62positive regulation of histone deacetylation (GO:0031065)2.51728590
63positive regulation of granulocyte differentiation (GO:0030854)2.51063235
64necrotic cell death (GO:0070265)2.50065717
65pre-miRNA processing (GO:0031054)2.49950618
66cellular response to epinephrine stimulus (GO:0071872)2.49482240
67interleukin-6-mediated signaling pathway (GO:0070102)2.48428114
68regulation of RNA export from nucleus (GO:0046831)2.47012105
69negative regulation of erythrocyte differentiation (GO:0045647)2.45166910
70T cell selection (GO:0045058)2.45048154
71establishment of nucleus localization (GO:0040023)2.44149585
72striated muscle atrophy (GO:0014891)2.44073518
73regulation of B cell differentiation (GO:0045577)2.42069924
74positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.41663511
75peptidyl-threonine modification (GO:0018210)2.40032677
76histone H3-K9 demethylation (GO:0033169)2.39704400
77peptidyl-threonine phosphorylation (GO:0018107)2.39636714
78microglial cell activation (GO:0001774)2.39630560
79peptidyl-lysine trimethylation (GO:0018023)2.39560507
80phospholipid translocation (GO:0045332)2.39370236
81lipid translocation (GO:0034204)2.39370236
82definitive hemopoiesis (GO:0060216)2.38932801
83peptidyl-lysine dimethylation (GO:0018027)2.38809823
84embryonic process involved in female pregnancy (GO:0060136)2.38726481
85B cell homeostasis (GO:0001782)2.38670848
86negative regulation of necroptotic process (GO:0060546)2.37561209
87positive regulation of Rap GTPase activity (GO:0032854)2.37128755
88signal complex assembly (GO:0007172)2.36701258
89pore complex assembly (GO:0046931)2.36291674
90programmed necrotic cell death (GO:0097300)2.35716813
91hypotonic response (GO:0006971)2.35387042
92cortical actin cytoskeleton organization (GO:0030866)2.34616771
93negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.34294686
94layer formation in cerebral cortex (GO:0021819)2.34133231
95negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.33992719
96negative regulation of T-helper cell differentiation (GO:0045623)2.33992719
97negative regulation of T cell mediated immunity (GO:0002710)2.33602392
98response to interleukin-15 (GO:0070672)2.32830616
99nuclear pore complex assembly (GO:0051292)2.32459185
100histone demethylation (GO:0016577)2.32313419
101T cell migration (GO:0072678)2.31612703
102neutrophil mediated immunity (GO:0002446)2.30982631
103detection of external biotic stimulus (GO:0098581)2.30642755
104regulation of histone H3-K27 methylation (GO:0061085)2.30623611
105fusion of sperm to egg plasma membrane (GO:0007342)2.30589496
106cellular response to nerve growth factor stimulus (GO:1990090)2.29394239
107response to nerve growth factor (GO:1990089)2.29394239
108proline transport (GO:0015824)2.28785220
109positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.28320764
110cellular potassium ion homeostasis (GO:0030007)2.28126438
111antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.27893585
112detection of biotic stimulus (GO:0009595)2.27534731
113dosage compensation (GO:0007549)2.27079071
114antigen processing and presentation of endogenous antigen (GO:0019883)2.27004321
115B cell proliferation (GO:0042100)2.26073782
116positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.25923444
117glutamate secretion (GO:0014047)2.25703266
118myeloid leukocyte mediated immunity (GO:0002444)2.25555196
119positive regulation of DNA-templated transcription, initiation (GO:2000144)2.25349267
120regulation of Rap GTPase activity (GO:0032317)2.24962427
121regulation of interferon-beta biosynthetic process (GO:0045357)2.24506579
122regulation of T-helper 2 cell differentiation (GO:0045628)2.24404797
123cellular response to growth hormone stimulus (GO:0071378)2.23730976
124antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.23172603
125positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.23010254
126response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.22626536
127response to host (GO:0075136)2.22626536
128response to host defenses (GO:0052200)2.22626536
129peptidyl-serine phosphorylation (GO:0018105)2.22419396
130negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.20978012
131negative regulation of translation, ncRNA-mediated (GO:0040033)2.20978012
132regulation of translation, ncRNA-mediated (GO:0045974)2.20978012
133mitotic sister chromatid cohesion (GO:0007064)2.20340830
134germ cell migration (GO:0008354)2.16741202
135regulation of necroptotic process (GO:0060544)2.16588787
136histone H3-K4 trimethylation (GO:0080182)2.16125035
137activation of protein kinase A activity (GO:0034199)2.16060911
138regulation of gamma-delta T cell activation (GO:0046643)2.14577904
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.14012495
140protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.13967255
141activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.12648110
142negative regulation of fatty acid transport (GO:2000192)2.11816536
143regulation of interleukin-12 biosynthetic process (GO:0045075)2.11166817
144protein localization to endosome (GO:0036010)2.10256651
145regulation of gamma-delta T cell differentiation (GO:0045586)2.09528862
146positive T cell selection (GO:0043368)2.07711237
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.07481834
148regulation of synaptic vesicle exocytosis (GO:2000300)2.06721513
149vesicle coating (GO:0006901)2.02991045
150I-kappaB phosphorylation (GO:0007252)2.02368187
151phosphatidylinositol phosphorylation (GO:0046854)2.01776637
152muscle atrophy (GO:0014889)2.01063489
153positive regulation of Rab GTPase activity (GO:0032851)2.01007006
154regulation of Rab GTPase activity (GO:0032313)2.01007006
155insulin-like growth factor receptor signaling pathway (GO:0048009)2.00776785
156dendrite morphogenesis (GO:0048813)2.00553224
157histone lysine demethylation (GO:0070076)1.99560994
158thymic T cell selection (GO:0045061)1.98944049
159regulation of translational termination (GO:0006449)1.98615848
160regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.98123289
161activation of JUN kinase activity (GO:0007257)1.97586429
162phosphatidylinositol dephosphorylation (GO:0046856)1.97445474
163actin filament capping (GO:0051693)1.97252578
164negative thymic T cell selection (GO:0045060)1.96659114
165neuromuscular process controlling balance (GO:0050885)1.96555806
166positive regulation of nuclease activity (GO:0032075)1.95613209
167apoptotic cell clearance (GO:0043277)1.95226465
168positive regulation of p38MAPK cascade (GO:1900745)1.95081002
169cell wall macromolecule catabolic process (GO:0016998)1.94164544
170cell wall macromolecule metabolic process (GO:0044036)1.94164544

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human3.45920854
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.27856770
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.77536744
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.65196754
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.20202245
6EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91639588
7SCL_19346495_ChIP-Seq_HPC-7_Human1.86388016
8SMAD_19615063_ChIP-ChIP_OVARY_Human1.79048302
9STAT6_21828071_ChIP-Seq_BEAS2B_Human1.73141302
10TCF7_22412390_ChIP-Seq_EML_Mouse1.72589454
11IRF8_21731497_ChIP-ChIP_J774_Mouse1.69059738
12SALL1_21062744_ChIP-ChIP_HESCs_Human1.67805481
13KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66621908
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65683655
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.63788997
16KDM2B_26808549_Chip-Seq_DND41_Human1.59133041
17DROSHA_22980978_ChIP-Seq_HELA_Human1.55208886
18KDM2B_26808549_Chip-Seq_K562_Human1.54399138
19GBX2_23144817_ChIP-Seq_PC3_Human1.52720250
20DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52587688
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51277819
22KDM2B_26808549_Chip-Seq_SUP-B15_Human1.51231247
23FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.47964903
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45286626
25TP53_16413492_ChIP-PET_HCT116_Human1.44714297
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43585409
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.43415490
28TAF15_26573619_Chip-Seq_HEK293_Human1.42678156
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.42148459
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41635520
31ZNF217_24962896_ChIP-Seq_MCF-7_Human1.41507404
32FOXO3_23340844_ChIP-Seq_DLD1_Human1.39459675
33IRF8_22096565_ChIP-ChIP_GC-B_Human1.38621127
34CTNNB1_20460455_ChIP-Seq_HCT116_Human1.36611025
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.35650285
36SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34531969
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32033157
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29313664
39* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.29267500
40FOXA2_19822575_ChIP-Seq_HepG2_Human1.29022803
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28872722
42NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28360061
43NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28360061
44ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.26907386
45KDM2B_26808549_Chip-Seq_JURKAT_Human1.26810235
46* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26725121
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26484748
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.25915853
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.23780041
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.23412498
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.22961330
52GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22675359
53* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22239891
54PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21537887
55NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.21208590
56TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21154547
57AR_21572438_ChIP-Seq_LNCaP_Human1.20830005
58SPI1_23127762_ChIP-Seq_K562_Human1.20753105
59GATA1_22025678_ChIP-Seq_K562_Human1.20556458
60RARB_27405468_Chip-Seq_BRAIN_Mouse1.20137311
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.18877154
62RUNX_20019798_ChIP-Seq_JUKART_Human1.15596257
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13353258
64TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11801027
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10588297
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09751277
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.09490306
68EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09432900
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.08903622
70NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07969701
71BRD4_27068464_Chip-Seq_AML-cells_Mouse1.07714148
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.07213832
73PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07054550
74MYC_22102868_ChIP-Seq_BL_Human1.06849291
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05727747
76SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04913536
77GATA3_27048872_Chip-Seq_THYMUS_Human1.04829167
78* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04078248
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04030080
80PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03148980
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.02714058
82ELK4_26923725_Chip-Seq_MESODERM_Mouse1.02667632
83GATA1_19941826_ChIP-Seq_K562_Human1.02201501
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.00755804
85AHR_22903824_ChIP-Seq_MCF-7_Human1.00142500
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99563900
87YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99081715
88KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98481437
89* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97829258
90GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97523849
91ARNT_22903824_ChIP-Seq_MCF-7_Human0.96074341
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95959464
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95951457
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.95233983
95FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95167058
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95090200
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94761440
98GATA2_19941826_ChIP-Seq_K562_Human0.93536510
99E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.92997382
100VDR_24763502_ChIP-Seq_THP-1_Human0.92455383
101* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92440521
102PRDM14_20953172_ChIP-Seq_ESCs_Human0.92032315
103VDR_24787735_ChIP-Seq_THP-1_Human0.91378157
104* MYB_26560356_Chip-Seq_TH1_Human0.91136824
105LXR_22158963_ChIP-Seq_LIVER_Mouse0.90828285
106GATA1_19941827_ChIP-Seq_MEL_Mouse0.90598894
107TCF4_23295773_ChIP-Seq_U87_Human0.90532970
108SMAD4_21799915_ChIP-Seq_A2780_Human0.90473963
109UTX_26944678_Chip-Seq_JUKART_Human0.90444979
110BRD4_25478319_ChIP-Seq_HGPS_Human0.90042387
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.89981423
112AR_19668381_ChIP-Seq_PC3_Human0.89343703
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89195369
114SPI1_23547873_ChIP-Seq_NB4_Human0.89140716
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.89132638
116STAT3_23295773_ChIP-Seq_U87_Human0.88987782
117NR3C1_23031785_ChIP-Seq_PC12_Mouse0.88911053
118SMRT_27268052_Chip-Seq_Bcells_Human0.88910717
119ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88875414
120MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88616405
121TP63_23658742_ChIP-Seq_EP156T_Human0.88591334
122IGF1R_20145208_ChIP-Seq_DFB_Human0.88342850
123MYB_26560356_Chip-Seq_TH2_Human0.87353715
124SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87069043
125CMYC_18555785_Chip-Seq_ESCs_Mouse0.86821103
126MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86755272
127GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86604858
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86466327
129FLI1_21867929_ChIP-Seq_TH2_Mouse0.86061474
130KDM2B_26808549_Chip-Seq_REH_Human0.85670831
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.85588350
132TCF4_18268006_ChIP-ChIP_LS174T_Human0.85055027
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.84699528
134RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.83982497
135RXR_22108803_ChIP-Seq_LS180_Human0.83268279
136BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83195094
137MAF_26560356_Chip-Seq_TH1_Human0.83123047
138SOX2_21211035_ChIP-Seq_LN229_Gbm0.82345280
139PU_27001747_Chip-Seq_BMDM_Mouse0.81994751
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81639324
141FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.81145385
142ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80806061
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.79678379

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.30763182
2MP0008057_abnormal_DNA_replication3.83490106
3MP0003300_gastrointestinal_ulcer3.40419590
4MP0002877_abnormal_melanocyte_morpholog3.25183171
5MP0002254_reproductive_system_inflammat3.08408825
6MP0003705_abnormal_hypodermis_morpholog3.05414162
7MP0004859_abnormal_synaptic_plasticity2.91927205
8MP0002138_abnormal_hepatobiliary_system2.71346418
9MP0010352_gastrointestinal_tract_polyps2.52143844
10MP0005076_abnormal_cell_differentiation2.46497876
11MP0003045_fibrosis2.39795037
12MP0003252_abnormal_bile_duct2.34135009
13MP0001348_abnormal_lacrimal_gland2.31633465
14MP0003828_pulmonary_edema2.30403450
15MP0003763_abnormal_thymus_physiology2.29214712
16MP0003303_peritoneal_inflammation2.20742419
17MP0004510_myositis2.20366183
18MP0010307_abnormal_tumor_latency2.14966494
19MP0008961_abnormal_basal_metabolism2.14177478
20MP0003724_increased_susceptibility_to2.13942907
21MP0003787_abnormal_imprinting2.11958574
22MP0009780_abnormal_chondrocyte_physiolo2.11457936
23MP0003172_abnormal_lysosome_physiology2.06524364
24MP0003183_abnormal_peptide_metabolism1.94285323
25MP0010234_abnormal_vibrissa_follicle1.93772944
26MP0005671_abnormal_response_to1.85021735
27MP0009278_abnormal_bone_marrow1.77761889
28MP0003091_abnormal_cell_migration1.77665730
29MP0005000_abnormal_immune_tolerance1.70804057
30MP0000685_abnormal_immune_system1.67816372
31MP0002928_abnormal_bile_duct1.66965290
32MP0002909_abnormal_adrenal_gland1.62148461
33MP0008260_abnormal_autophagy1.56366734
34MP0003191_abnormal_cellular_cholesterol1.54492334
35MP0008877_abnormal_DNA_methylation1.47502619
36MP0004808_abnormal_hematopoietic_stem1.46677184
37MP0008004_abnormal_stomach_pH1.46060173
38MP0001873_stomach_inflammation1.43629038
39MP0001851_eye_inflammation1.41815778
40MP0002166_altered_tumor_susceptibility1.40572872
41MP0004084_abnormal_cardiac_muscle1.39248436
42MP0005174_abnormal_tail_pigmentation1.38970706
43MP0009046_muscle_twitch1.35727290
44MP0005410_abnormal_fertilization1.35265772
45MP0004947_skin_inflammation1.34338750
46MP0005409_darkened_coat_color1.33704426
47MP0003950_abnormal_plasma_membrane1.32868956
48MP0005623_abnormal_meninges_morphology1.30900984
49MP0003566_abnormal_cell_adhesion1.24650377
50MP0004883_abnormal_blood_vessel1.24479972
51MP0003690_abnormal_glial_cell1.22804692
52MP0000604_amyloidosis1.22013220
53MP0005025_abnormal_response_to1.21870798
54MP0003283_abnormal_digestive_organ1.18399166
55MP0004036_abnormal_muscle_relaxation1.14008250
56MP0003279_aneurysm1.13102726
57MP0002089_abnormal_postnatal_growth/wei1.10892806
58MP0000371_diluted_coat_color1.08953904
59MP0003890_abnormal_embryonic-extraembry1.08952908
60MP0001545_abnormal_hematopoietic_system1.08480568
61MP0005397_hematopoietic_system_phenotyp1.08480568
62MP0005388_respiratory_system_phenotype1.07631823
63MP0002133_abnormal_respiratory_system1.07631823
64MP0004811_abnormal_neuron_physiology1.06677871
65MP0002168_other_aberrant_phenotype1.05697018
66MP0006082_CNS_inflammation1.05527358
67MP0000689_abnormal_spleen_morphology1.04632344
68MP0005275_abnormal_skin_tensile1.03119747
69MP0002139_abnormal_hepatobiliary_system1.03081508
70MP0001299_abnormal_eye_distance/1.01372706
71MP0002722_abnormal_immune_system1.00734979
72MP0003635_abnormal_synaptic_transmissio1.00712143
73MP0005451_abnormal_body_composition1.00697666
74MP0005310_abnormal_salivary_gland1.00335259
75MP0005464_abnormal_platelet_physiology1.00140748
76MP0000733_abnormal_muscle_development0.97734602
77MP0001835_abnormal_antigen_presentation0.95551291
78MP0004270_analgesia0.95520412
79MP0002009_preneoplasia0.95139881
80MP0006054_spinal_hemorrhage0.95091123
81MP0003221_abnormal_cardiomyocyte_apopto0.93185424
82MP0002429_abnormal_blood_cell0.93153802
83MP0004264_abnormal_extraembryonic_tissu0.92080726
84MP0005360_urolithiasis0.92075454
85MP0003436_decreased_susceptibility_to0.91037396
86MP0001533_abnormal_skeleton_physiology0.90319776
87MP0005645_abnormal_hypothalamus_physiol0.90072204
88MP0000920_abnormal_myelination0.88812850
89MP0003656_abnormal_erythrocyte_physiolo0.88288717
90MP0009115_abnormal_fat_cell0.86573621
91MP0002006_tumorigenesis0.86558435
92MP0004858_abnormal_nervous_system0.86051256
93MP0005164_abnormal_response_to0.85220135
94MP0003879_abnormal_hair_cell0.84200559
95MP0001790_abnormal_immune_system0.84153449
96MP0005387_immune_system_phenotype0.84153449
97MP0000015_abnormal_ear_pigmentation0.83743596
98MP0000003_abnormal_adipose_tissue0.82610255
99MP0001958_emphysema0.82177403
100MP0004130_abnormal_muscle_cell0.81178955
101MP0004484_altered_response_of0.79462849
102MP0004134_abnormal_chest_morphology0.78845866
103MP0002405_respiratory_system_inflammati0.77977236
104MP0008438_abnormal_cutaneous_collagen0.77480831
105MP0001845_abnormal_inflammatory_respons0.77223708
106MP0001915_intracranial_hemorrhage0.76990413
107MP0005083_abnormal_biliary_tract0.76579629
108MP0004381_abnormal_hair_follicle0.75849500
109MP0002398_abnormal_bone_marrow0.75335583
110MP0000767_abnormal_smooth_muscle0.74624275
111MP0000465_gastrointestinal_hemorrhage0.74378718
112MP0010155_abnormal_intestine_physiology0.74053329
113MP0005058_abnormal_lysosome_morphology0.73780896
114MP0009785_altered_susceptibility_to0.73459901
115MP0010678_abnormal_skin_adnexa0.73099213
116MP0005621_abnormal_cell_physiology0.72712599
117MP0001800_abnormal_humoral_immune0.72590260
118MP0002896_abnormal_bone_mineralization0.71827280
119MP0005023_abnormal_wound_healing0.71516299
120MP0000249_abnormal_blood_vessel0.70949160
121MP0002148_abnormal_hypersensitivity_rea0.69348816
122MP0008569_lethality_at_weaning0.67872872
123MP0005503_abnormal_tendon_morphology0.67670828
124MP0000703_abnormal_thymus_morphology0.66182464
125MP0003866_abnormal_defecation0.66117091
126MP0002063_abnormal_learning/memory/cond0.65694680
127MP0003698_abnormal_male_reproductive0.65011219
128MP0000609_abnormal_liver_physiology0.64917965
129MP0002452_abnormal_antigen_presenting0.64758874
130MP0002419_abnormal_innate_immunity0.61871570
131MP0005365_abnormal_bile_salt0.61701679
132MP0003448_altered_tumor_morphology0.61455773
133MP0001849_ear_inflammation0.60991614
134MP0009703_decreased_birth_body0.59769303
135MP0005448_abnormal_energy_balance0.59606259
136MP0003633_abnormal_nervous_system0.59225718
137MP0003453_abnormal_keratinocyte_physiol0.58216153
138MP0002723_abnormal_immune_serum0.57203074
139MP0003075_altered_response_to0.56168296
140MP0002396_abnormal_hematopoietic_system0.56063981
141MP0001819_abnormal_immune_cell0.54254449
142MP0000716_abnormal_immune_system0.53448924
143MP0001929_abnormal_gametogenesis0.52936077
144MP0002420_abnormal_adaptive_immunity0.52537655
145MP0002998_abnormal_bone_remodeling0.52507196

Predicted human phenotypes

RankGene SetZ-score
1Macroorchidism (HP:0000053)3.61670630
2Heterotopia (HP:0002282)3.25110550
3Hyperacusis (HP:0010780)3.24731570
4Abnormality of the lower motor neuron (HP:0002366)2.99241497
5Eczematoid dermatitis (HP:0000976)2.81854658
6T lymphocytopenia (HP:0005403)2.80302668
7Arterial tortuosity (HP:0005116)2.79208273
8Recurrent bacterial skin infections (HP:0005406)2.76808523
9Renovascular hypertension (HP:0100817)2.75123035
10Elfin facies (HP:0004428)2.73148613
11Abnormality of T cell number (HP:0011839)2.71096041
12Absent frontal sinuses (HP:0002688)2.66196768
13Vascular tortuosity (HP:0004948)2.65887879
14Cerebral aneurysm (HP:0004944)2.64120100
15Spontaneous hematomas (HP:0007420)2.60076819
16Abnormality of the fingertips (HP:0001211)2.58743093
17Aortic aneurysm (HP:0004942)2.57927879
18Spondylolisthesis (HP:0003302)2.56969765
19Insomnia (HP:0100785)2.54489258
20Recurrent abscess formation (HP:0002722)2.53907078
21Aortic dissection (HP:0002647)2.46247883
22Subacute progressive viral hepatitis (HP:0006572)2.42507779
23Cellulitis (HP:0100658)2.42506234
24Abnormal delayed hypersensitivity skin test (HP:0002963)2.38192770
25Hand muscle atrophy (HP:0009130)2.35796242
26Recurrent viral infections (HP:0004429)2.35530027
27Bowel diverticulosis (HP:0005222)2.34892376
28Gingival bleeding (HP:0000225)2.28458326
29Upper limb amyotrophy (HP:0009129)2.26958132
30Distal upper limb amyotrophy (HP:0007149)2.26958132
31Acute myeloid leukemia (HP:0004808)2.26491004
32Recurrent fungal infections (HP:0002841)2.24121951
33Relative macrocephaly (HP:0004482)2.23536141
34Gingivitis (HP:0000230)2.21985007
35Dilatation of the ascending aorta (HP:0005111)2.21592888
36Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19956031
37Peritonitis (HP:0002586)2.18567011
38Urinary bladder sphincter dysfunction (HP:0002839)2.18054234
39Genetic anticipation (HP:0003743)2.17697437
40Pointed chin (HP:0000307)2.17671094
41Narrow palate (HP:0000189)2.16582031
42Colitis (HP:0002583)2.15057293
43Dysmetric saccades (HP:0000641)2.09363017
44Mediastinal lymphadenopathy (HP:0100721)2.09289016
45Volvulus (HP:0002580)2.08625941
46Recurrent cutaneous fungal infections (HP:0011370)2.06555333
47Chronic mucocutaneous candidiasis (HP:0002728)2.06555333
48Overriding aorta (HP:0002623)2.06289578
49Action tremor (HP:0002345)2.06183120
50Fatigue (HP:0012378)2.05401200
51Slow saccadic eye movements (HP:0000514)2.05399914
52Gastrointestinal infarctions (HP:0005244)2.03783314
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03665382
54Lower limb amyotrophy (HP:0007210)2.02364740
55Osteolytic defects of the hand bones (HP:0009699)2.01955524
56Osteolytic defects of the phalanges of the hand (HP:0009771)2.01955524
57Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.01953923
58Obsessive-compulsive behavior (HP:0000722)2.01726265
59Retrobulbar optic neuritis (HP:0100654)2.00636943
60Optic neuritis (HP:0100653)2.00636943
61Chest pain (HP:0100749)1.98520602
62Overgrowth (HP:0001548)1.98028265
63Glucose intolerance (HP:0000833)1.96736687
64Abnormality of ocular smooth pursuit (HP:0000617)1.96379113
65Papillary thyroid carcinoma (HP:0002895)1.96308881
66Truncal obesity (HP:0001956)1.95001092
67Mitral valve prolapse (HP:0001634)1.94979981
68Focal seizures (HP:0007359)1.93427133
69Bladder diverticulum (HP:0000015)1.93171104
70Osteomyelitis (HP:0002754)1.92775460
71Impaired smooth pursuit (HP:0007772)1.91532974
72Renal duplication (HP:0000075)1.91042326
73Pulmonary infiltrates (HP:0002113)1.90889106
74Agammaglobulinemia (HP:0004432)1.90496392
75Persistence of primary teeth (HP:0006335)1.89209294
76Meningitis (HP:0001287)1.88637939
77Autoimmune hemolytic anemia (HP:0001890)1.86819789
78Global brain atrophy (HP:0002283)1.86652166
79Thyroid carcinoma (HP:0002890)1.85366185
80Papilledema (HP:0001085)1.84359699
81Orchitis (HP:0100796)1.84013372
82Aneurysm (HP:0002617)1.83202980
83Widely spaced teeth (HP:0000687)1.83146603
84Scanning speech (HP:0002168)1.82716898
85Mild short stature (HP:0003502)1.82425020
86Curly hair (HP:0002212)1.82219834
87Hematochezia (HP:0002573)1.82162985
88Truncal ataxia (HP:0002078)1.81549221
89Recurrent skin infections (HP:0001581)1.81493574
90Supranuclear gaze palsy (HP:0000605)1.81242641
91Inflammation of the large intestine (HP:0002037)1.79691607
92Vasculitis (HP:0002633)1.78611069
93Cubitus valgus (HP:0002967)1.78035262
94Myositis (HP:0100614)1.77477881
95Myocardial infarction (HP:0001658)1.77302539
96Generalized hypopigmentation of hair (HP:0011358)1.76400327
97Nasal polyposis (HP:0100582)1.75848879
98Arterial thrombosis (HP:0004420)1.75451111
99Long toe (HP:0010511)1.74870073
100Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.74119097
101Recurrent bronchitis (HP:0002837)1.73076736
102Abnormal platelet volume (HP:0011876)1.72928113
103Menstrual irregularities (HP:0000858)1.72781301
104Increased CSF protein (HP:0002922)1.72157447
105Striae distensae (HP:0001065)1.71614352
106Frequent falls (HP:0002359)1.70918292
107Bladder neoplasm (HP:0009725)1.70812150
108Bladder carcinoma (HP:0002862)1.70812150
109Urethral obstruction (HP:0000796)1.70544445
110Interstitial pulmonary disease (HP:0006530)1.69884460
111Hemiplegia (HP:0002301)1.69881199
112Abnormality of macrophages (HP:0004311)1.69786797
113Ocular albinism (HP:0001107)1.69732491
114Coarse hair (HP:0002208)1.69513728
115Abnormal glucose tolerance (HP:0001952)1.69301564
116Acanthocytosis (HP:0001927)1.69027067
117Flat cornea (HP:0007720)1.68564304
118Mitral stenosis (HP:0001718)1.68503027
119Deep philtrum (HP:0002002)1.68228952
120Shallow orbits (HP:0000586)1.68118375
121Eosinophilia (HP:0001880)1.68073483
122Leukocytosis (HP:0001974)1.67807717
123Epistaxis (HP:0000421)1.67604552
124Astrocytoma (HP:0009592)1.67244164
125Abnormality of the astrocytes (HP:0100707)1.67244164
126Sandal gap (HP:0001852)1.67102262
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67093525
128Thoracolumbar scoliosis (HP:0002944)1.66892949
129Neonatal hypoglycemia (HP:0001998)1.66626466
130Gastrointestinal inflammation (HP:0004386)1.66281377
131Abnormality of the gastric mucosa (HP:0004295)1.65359245
132Increased nuchal translucency (HP:0010880)1.65337934
133Hypercortisolism (HP:0001578)1.64972247
134Prolonged bleeding time (HP:0003010)1.64758431
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.64179110
136Absent/shortened dynein arms (HP:0200106)1.64179110
137Urinary urgency (HP:0000012)1.63255391
138Fair hair (HP:0002286)1.63155025
139Polygenic inheritance (HP:0010982)1.61235497
140Progressive cerebellar ataxia (HP:0002073)1.57999611
141Trigonocephaly (HP:0000243)1.56165842
142Genu recurvatum (HP:0002816)1.55109589
143Abnormal social behavior (HP:0012433)1.54952874
144Impaired social interactions (HP:0000735)1.54952874
145Smooth philtrum (HP:0000319)1.53558520
146Postural instability (HP:0002172)1.53048750
147Enlarged penis (HP:0000040)1.52303997
148Vertebral arch anomaly (HP:0008438)1.51512550
149Febrile seizures (HP:0002373)1.51387050
150Transitional cell carcinoma of the bladder (HP:0006740)1.49437617
151Depression (HP:0000716)1.49194764
152Impaired vibration sensation in the lower limbs (HP:0002166)1.48136012
153Distal lower limb amyotrophy (HP:0008944)1.47226611
154Inappropriate behavior (HP:0000719)1.46626823
155Prominent nose (HP:0000448)1.46232773
156Ankle clonus (HP:0011448)1.45915330
157Turricephaly (HP:0000262)1.43885029
158Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.43520230
159Viral hepatitis (HP:0006562)1.43493724
160Dislocated radial head (HP:0003083)1.42910784
161Bilateral sensorineural hearing impairment (HP:0008619)1.42899768
162Abnormality of the frontal sinuses (HP:0002687)1.41372561
163Disproportionate tall stature (HP:0001519)1.41144801
164Neoplasm of the heart (HP:0100544)1.41091302
165Broad palm (HP:0001169)1.40975149
166Autoimmune thrombocytopenia (HP:0001973)1.40929314
167Sacral dimple (HP:0000960)1.40607843
168Progressive hearing impairment (HP:0001730)1.39737117
169Hallux valgus (HP:0001822)1.38865212
170Protrusio acetabuli (HP:0003179)1.38553170
171Visual hallucinations (HP:0002367)1.38350969
172Long eyelashes (HP:0000527)1.38328681
173Syringomyelia (HP:0003396)1.38305328
174Spinal cord lesions (HP:0100561)1.38305328
175Abnormality of the radial head (HP:0003995)1.38111245

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.01625390
2RIPK12.72079222
3AKT32.69650247
4CDK122.38496400
5MAP3K92.15002640
6PTK62.13553133
7PRPF4B1.99345867
8PDGFRA1.95828769
9CAMKK11.82546000
10STK31.76927402
11BLK1.75314276
12FRK1.75057837
13TGFBR21.74902128
14TRIB31.74760073
15DAPK21.74265222
16SCYL21.74208659
17NEK91.71594745
18TAOK31.69381764
19JAK11.67454850
20PRKD31.64422754
21BMPR21.59275199
22CAMK1G1.59123813
23JAK31.56325204
24IRAK11.55211986
25NTRK31.53745621
26MAP3K101.53684323
27PKN21.51788358
28SIK21.47675579
29PIK3CG1.47295442
30PAK61.43084105
31PDGFRB1.42872131
32LATS11.42395770
33IRAK21.41346284
34MAP3K21.38423847
35DDR21.36668311
36SGK31.35239363
37FGFR41.30543552
38PTK21.30133099
39RET1.27821803
40BTK1.27793080
41KSR11.26193622
42CAMK1D1.24537112
43TYK21.23498928
44LMTK21.21990401
45MAP3K141.21282583
46MAP2K31.20871418
47ALK1.19013221
48STK381.18781797
49TEC1.17066119
50FGFR31.16987497
51MAP4K11.16966736
52SYK1.15627886
53RIPK41.15175759
54NTRK11.14232186
55PDK41.12774180
56PDK31.12774180
57IRAK41.11529016
58WNK11.11445445
59MAPKAPK31.09701053
60ICK1.09350425
61MTOR1.08125089
62CDK61.06207878
63TAOK11.05587156
64DYRK1B1.04681483
65TTN1.02398129
66CSK1.01828854
67YES11.01404765
68MAP3K130.99103036
69CAMKK20.97815937
70JAK20.97486140
71MAP3K40.97138135
72FES0.96682248
73SGK20.94888195
74PRKCH0.92516647
75TYRO30.90060095
76KSR20.88064346
77TRPM70.85627231
78CHUK0.85059761
79NEK60.83846606
80SGK4940.83702970
81SGK2230.83702970
82ITK0.82833705
83FLT30.82106692
84SIK10.81675423
85BRD40.81300952
86MARK30.80995561
87MINK10.79635544
88NLK0.79499523
89MAP3K70.78591458
90MAPK70.77024639
91PTK2B0.73957955
92CDC42BPA0.73784000
93MAP3K60.73705187
94PAK30.73073394
95CSF1R0.72978804
96RPS6KA20.72277712
97ERBB30.71202950
98TBK10.70710943
99CAMK40.70605375
100MELK0.70084659
101PAK20.69485856
102DMPK0.69452199
103FGR0.69002875
104PDK10.67352288
105MAP3K10.67211834
106SIK30.65884136
107DAPK10.64221995
108MAPK110.63954468
109EPHA30.63345050
110HCK0.63271400
111BMX0.62797589
112SGK10.62721589
113NEK20.61882834
114MAPK120.61651139
115MARK10.61625186
116EPHB10.61113721
117MAP3K50.59386400
118NTRK20.58952416
119LATS20.57083116
120PDPK10.55577736
121MAPK100.55487512
122STK110.53954606
123FGFR20.53527044
124CDK50.52645264
125TXK0.50874959
126LYN0.50685995
127PRKAA10.50457613
128LCK0.50413139
129DYRK1A0.49766760
130MAP3K30.49573050
131ERN10.48881252
132IKBKE0.48682133
133GRK60.47116001
134ERBB20.47050325
135KIT0.46949937
136MAP2K40.46319549
137MARK20.46202452
138RAF10.45914683
139EGFR0.45912961
140MAPK80.44261909
141FGFR10.43747636
142STK240.43422400
143ZAP700.43353985

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009101.79197847
2Type II diabetes mellitus_Homo sapiens_hsa049301.76987380
3Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54649870
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.54235678
5Chronic myeloid leukemia_Homo sapiens_hsa052201.47703534
6Dorso-ventral axis formation_Homo sapiens_hsa043201.42310903
7Phosphatidylinositol signaling system_Homo sapiens_hsa040701.37575481
8Renal cell carcinoma_Homo sapiens_hsa052111.35810456
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.30619622
10Glioma_Homo sapiens_hsa052141.24993606
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22404697
12mTOR signaling pathway_Homo sapiens_hsa041501.20260484
13Osteoclast differentiation_Homo sapiens_hsa043801.19721886
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.15673968
15Synaptic vesicle cycle_Homo sapiens_hsa047211.14643391
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.14187443
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.12846347
18Lysine degradation_Homo sapiens_hsa003101.11710020
19Neurotrophin signaling pathway_Homo sapiens_hsa047221.11168713
20Prolactin signaling pathway_Homo sapiens_hsa049171.08475717
21Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07617963
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06395598
23Endometrial cancer_Homo sapiens_hsa052131.06318705
24Insulin resistance_Homo sapiens_hsa049311.06089369
25TNF signaling pathway_Homo sapiens_hsa046681.01636087
26Long-term potentiation_Homo sapiens_hsa047201.01220455
27Estrogen signaling pathway_Homo sapiens_hsa049151.00869856
28Graft-versus-host disease_Homo sapiens_hsa053321.00582492
29Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00065572
30Non-small cell lung cancer_Homo sapiens_hsa052230.99139620
31B cell receptor signaling pathway_Homo sapiens_hsa046620.98707850
32Pancreatic cancer_Homo sapiens_hsa052120.97258635
33Toxoplasmosis_Homo sapiens_hsa051450.96715026
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96714008
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.96146067
36T cell receptor signaling pathway_Homo sapiens_hsa046600.95863099
37Leukocyte transendothelial migration_Homo sapiens_hsa046700.95473937
38Bile secretion_Homo sapiens_hsa049760.95177648
39Insulin secretion_Homo sapiens_hsa049110.94517447
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94310343
41NF-kappa B signaling pathway_Homo sapiens_hsa040640.92851644
42Sphingolipid signaling pathway_Homo sapiens_hsa040710.92190953
43Gastric acid secretion_Homo sapiens_hsa049710.91474191
44Small cell lung cancer_Homo sapiens_hsa052220.90982370
45ErbB signaling pathway_Homo sapiens_hsa040120.90924009
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.89340249
47Allograft rejection_Homo sapiens_hsa053300.88548511
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88470974
49Proteoglycans in cancer_Homo sapiens_hsa052050.87695067
50Autoimmune thyroid disease_Homo sapiens_hsa053200.87665455
51Inositol phosphate metabolism_Homo sapiens_hsa005620.87312912
52Viral myocarditis_Homo sapiens_hsa054160.87007070
53Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86165216
54Olfactory transduction_Homo sapiens_hsa047400.86054109
55Hepatitis C_Homo sapiens_hsa051600.84612908
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83226573
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82274647
58Chemokine signaling pathway_Homo sapiens_hsa040620.82052514
59Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.81709965
60Endocytosis_Homo sapiens_hsa041440.81530632
61Focal adhesion_Homo sapiens_hsa045100.80120572
62Salivary secretion_Homo sapiens_hsa049700.79645484
63Amphetamine addiction_Homo sapiens_hsa050310.78453739
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.78154893
65Colorectal cancer_Homo sapiens_hsa052100.77972583
66Circadian entrainment_Homo sapiens_hsa047130.77711127
67Amoebiasis_Homo sapiens_hsa051460.77198850
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.76985504
69MAPK signaling pathway_Homo sapiens_hsa040100.76755470
70GnRH signaling pathway_Homo sapiens_hsa049120.76720564
71VEGF signaling pathway_Homo sapiens_hsa043700.76635825
72Renin secretion_Homo sapiens_hsa049240.76416352
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76373886
74Glutamatergic synapse_Homo sapiens_hsa047240.75786898
75Staphylococcus aureus infection_Homo sapiens_hsa051500.75774143
76Adherens junction_Homo sapiens_hsa045200.75502183
77Oxytocin signaling pathway_Homo sapiens_hsa049210.75345291
78Glucagon signaling pathway_Homo sapiens_hsa049220.75339473
79Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74847179
80Primary immunodeficiency_Homo sapiens_hsa053400.74012046
81Acute myeloid leukemia_Homo sapiens_hsa052210.73130169
82FoxO signaling pathway_Homo sapiens_hsa040680.73091777
83Insulin signaling pathway_Homo sapiens_hsa049100.72920359
84Thyroid cancer_Homo sapiens_hsa052160.72731582
85Thyroid hormone synthesis_Homo sapiens_hsa049180.72697952
86Cholinergic synapse_Homo sapiens_hsa047250.72414984
87Toll-like receptor signaling pathway_Homo sapiens_hsa046200.72413202
88Viral carcinogenesis_Homo sapiens_hsa052030.72273094
89Herpes simplex infection_Homo sapiens_hsa051680.71944003
90MicroRNAs in cancer_Homo sapiens_hsa052060.71595481
91Leishmaniasis_Homo sapiens_hsa051400.71260824
92Platelet activation_Homo sapiens_hsa046110.70363039
93Hematopoietic cell lineage_Homo sapiens_hsa046400.69862946
94ABC transporters_Homo sapiens_hsa020100.69557341
95Hepatitis B_Homo sapiens_hsa051610.68978249
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68362664
97Choline metabolism in cancer_Homo sapiens_hsa052310.68292106
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.67863046
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66096997
100Apoptosis_Homo sapiens_hsa042100.65508919
101Dopaminergic synapse_Homo sapiens_hsa047280.65024781
102Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.64648005
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64295832
104Central carbon metabolism in cancer_Homo sapiens_hsa052300.63975867
105Malaria_Homo sapiens_hsa051440.63839612
106Phagosome_Homo sapiens_hsa041450.63322762
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62351755
108Influenza A_Homo sapiens_hsa051640.61723366
109Morphine addiction_Homo sapiens_hsa050320.60939606
110Long-term depression_Homo sapiens_hsa047300.60328332
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.60327860
112Circadian rhythm_Homo sapiens_hsa047100.60271444
113Measles_Homo sapiens_hsa051620.59431449
114Arginine biosynthesis_Homo sapiens_hsa002200.59404335
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.58933252
116cAMP signaling pathway_Homo sapiens_hsa040240.58587802
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58440743
118Asthma_Homo sapiens_hsa053100.57983716
119HTLV-I infection_Homo sapiens_hsa051660.57563654
120Ras signaling pathway_Homo sapiens_hsa040140.57508881
121Gap junction_Homo sapiens_hsa045400.57350416
122Legionellosis_Homo sapiens_hsa051340.56919931
123Tuberculosis_Homo sapiens_hsa051520.56849923
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56388422
125Melanoma_Homo sapiens_hsa052180.56332771
126cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54081386
127Rap1 signaling pathway_Homo sapiens_hsa040150.53902428
128GABAergic synapse_Homo sapiens_hsa047270.52978337
129Prostate cancer_Homo sapiens_hsa052150.50673386
130Bladder cancer_Homo sapiens_hsa052190.50454840

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