FAM13C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.32177297
2pyrimidine nucleobase catabolic process (GO:0006208)4.80992713
3vocalization behavior (GO:0071625)4.67700982
4axon ensheathment in central nervous system (GO:0032291)4.65308090
5central nervous system myelination (GO:0022010)4.65308090
6locomotory exploration behavior (GO:0035641)4.30152619
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23767696
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.21369383
9ionotropic glutamate receptor signaling pathway (GO:0035235)4.20978703
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.17684849
11glutamate receptor signaling pathway (GO:0007215)4.10553561
12L-amino acid import (GO:0043092)4.10178862
13synaptic vesicle exocytosis (GO:0016079)3.96725104
14presynaptic membrane assembly (GO:0097105)3.95241793
15neuron recognition (GO:0008038)3.92838137
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.92467825
17nucleobase catabolic process (GO:0046113)3.88128824
18protein localization to synapse (GO:0035418)3.87316010
19presynaptic membrane organization (GO:0097090)3.85718657
20glutamate secretion (GO:0014047)3.84676295
21neuronal action potential propagation (GO:0019227)3.79438179
22negative regulation of synaptic transmission, GABAergic (GO:0032229)3.76983016
23synaptic transmission, glutamatergic (GO:0035249)3.76021493
24regulation of glutamate receptor signaling pathway (GO:1900449)3.74678609
25axonal fasciculation (GO:0007413)3.70807400
26transmission of nerve impulse (GO:0019226)3.68490039
27amino acid import (GO:0043090)3.64056790
28neurotransmitter-gated ion channel clustering (GO:0072578)3.62729540
29neuron-neuron synaptic transmission (GO:0007270)3.61024413
30G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.59087410
31synaptic vesicle maturation (GO:0016188)3.54700886
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.48575625
33exploration behavior (GO:0035640)3.47353729
34regulation of neuronal synaptic plasticity (GO:0048168)3.46002133
35postsynaptic membrane organization (GO:0001941)3.44023130
36dendritic spine morphogenesis (GO:0060997)3.39726127
37layer formation in cerebral cortex (GO:0021819)3.38542209
38regulation of synaptic vesicle exocytosis (GO:2000300)3.36071506
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.34621874
40regulation of long-term neuronal synaptic plasticity (GO:0048169)3.33810700
41establishment of mitochondrion localization (GO:0051654)3.29946532
42retinal ganglion cell axon guidance (GO:0031290)3.22704318
43long-term synaptic potentiation (GO:0060291)3.22127058
44negative regulation of neurotransmitter transport (GO:0051589)3.19945905
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.19724920
46auditory behavior (GO:0031223)3.17944615
47regulation of synaptic transmission, glutamatergic (GO:0051966)3.16813034
48regulation of dendritic spine morphogenesis (GO:0061001)3.16445642
49cerebral cortex radially oriented cell migration (GO:0021799)3.16116292
50long-term memory (GO:0007616)3.15920858
51gamma-aminobutyric acid transport (GO:0015812)3.11882978
52positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.11625368
53C4-dicarboxylate transport (GO:0015740)3.10576880
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.10572222
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.08923392
56negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.04829676
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04607658
58neuronal ion channel clustering (GO:0045161)3.03924093
59regulation of synaptic vesicle transport (GO:1902803)3.02948767
60limb bud formation (GO:0060174)3.02248418
61regulation of synaptic plasticity (GO:0048167)3.00943330
62neuronal action potential (GO:0019228)2.99504369
63behavioral response to nicotine (GO:0035095)2.99335753
64myelination (GO:0042552)2.97077227
65regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.95978348
66dendrite morphogenesis (GO:0048813)2.95747034
67glycosphingolipid biosynthetic process (GO:0006688)2.94690063
68neuromuscular synaptic transmission (GO:0007274)2.94668513
69membrane depolarization during action potential (GO:0086010)2.94552108
70regulation of synapse structural plasticity (GO:0051823)2.94141636
71protein polyglutamylation (GO:0018095)2.94062467
72regulation of postsynaptic membrane potential (GO:0060078)2.93344644
73synaptic vesicle endocytosis (GO:0048488)2.92595040
74adult walking behavior (GO:0007628)2.91469620
75negative regulation of cytosolic calcium ion concentration (GO:0051481)2.90871551
76positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90772744
77ensheathment of neurons (GO:0007272)2.90049553
78axon ensheathment (GO:0008366)2.90049553
79neurotransmitter secretion (GO:0007269)2.89800197
80positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89653405
81short-term memory (GO:0007614)2.88990864
82response to auditory stimulus (GO:0010996)2.88877612
83cellular potassium ion homeostasis (GO:0030007)2.88475979
84mechanosensory behavior (GO:0007638)2.88188120
85cerebellar granule cell differentiation (GO:0021707)2.85123859
86long-chain fatty acid biosynthetic process (GO:0042759)2.82898772
87positive regulation of membrane potential (GO:0045838)2.82474214
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.82204381
89glycerophospholipid catabolic process (GO:0046475)2.79652198
90regulation of dendritic spine development (GO:0060998)2.79398141
91positive regulation of synapse assembly (GO:0051965)2.79174004
92synapse organization (GO:0050808)2.77416226
93startle response (GO:0001964)2.76879302
94negative regulation of protein localization to cell surface (GO:2000009)2.76636093
95calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76410135
96regulation of voltage-gated calcium channel activity (GO:1901385)2.76191932
97regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.74311378
98central nervous system neuron axonogenesis (GO:0021955)2.72435556
99learning (GO:0007612)2.69999818
100synapse assembly (GO:0007416)2.68793732
101acidic amino acid transport (GO:0015800)2.67696277
102dendrite development (GO:0016358)2.67567700
103neurotransmitter transport (GO:0006836)2.67214481
104neurotransmitter uptake (GO:0001504)2.67021945
105positive regulation of dendritic spine development (GO:0060999)2.65692076
106response to histamine (GO:0034776)2.65369890
107dendritic spine organization (GO:0097061)2.64036183
108regulation of vesicle fusion (GO:0031338)2.63710540
109central nervous system projection neuron axonogenesis (GO:0021952)2.62835872
110protein localization to cilium (GO:0061512)2.62022120
111cell migration in hindbrain (GO:0021535)2.61597933
112myelination in peripheral nervous system (GO:0022011)2.61482853
113peripheral nervous system axon ensheathment (GO:0032292)2.61482853
114regulation of synaptic transmission (GO:0050804)2.60616218
115regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.60202646
116regulation of glutamate secretion (GO:0014048)2.59635294
117apical protein localization (GO:0045176)2.59020529
118negative regulation of axonogenesis (GO:0050771)2.58509118
119membrane assembly (GO:0071709)2.58062218
120behavioral defense response (GO:0002209)2.57215236
121behavioral fear response (GO:0001662)2.57215236
122retinal cone cell development (GO:0046549)2.55336411
123positive regulation of dendritic spine morphogenesis (GO:0061003)2.53387195
124regulation of synaptic transmission, GABAergic (GO:0032228)2.50332316
125cilium or flagellum-dependent cell motility (GO:0001539)2.50307059
126somite development (GO:0061053)2.48877343
127behavioral response to ethanol (GO:0048149)2.47430832
128nonmotile primary cilium assembly (GO:0035058)2.46716046
129regulation of synapse assembly (GO:0051963)2.46601141
130regulation of cell communication by electrical coupling (GO:0010649)2.45976227
131establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.44747925
132mitochondrion transport along microtubule (GO:0047497)2.44747925
133cyclic nucleotide catabolic process (GO:0009214)2.43913844
134regulation of respiratory system process (GO:0044065)2.42351118
135adult behavior (GO:0030534)2.41937279
136positive regulation of potassium ion transmembrane transport (GO:1901381)2.41223389
137intraciliary transport (GO:0042073)2.41034070
138positive regulation of amino acid transport (GO:0051957)2.40825417
139positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.39460409
140epithelial cilium movement (GO:0003351)2.38086738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49047234
2GBX2_23144817_ChIP-Seq_PC3_Human3.69973987
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.90345902
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.86594894
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.79054423
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.51437048
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.51437048
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45375153
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43746680
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.36642229
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36298138
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.30028130
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28743133
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.25303488
15AR_21572438_ChIP-Seq_LNCaP_Human2.18387981
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17648073
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.09192426
18REST_21632747_ChIP-Seq_MESCs_Mouse2.07280972
19EZH2_27294783_Chip-Seq_ESCs_Mouse1.96105624
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95736618
21TAF15_26573619_Chip-Seq_HEK293_Human1.93833823
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88768777
23DROSHA_22980978_ChIP-Seq_HELA_Human1.87529636
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85765088
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83301477
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79615359
27PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72997265
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.71688924
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71005567
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69430118
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69288799
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.67468580
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67064929
34REST_18959480_ChIP-ChIP_MESCs_Mouse1.66621905
35* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.65440213
36* SMAD4_21799915_ChIP-Seq_A2780_Human1.65308166
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65282938
38CBX2_27304074_Chip-Seq_ESCs_Mouse1.62874380
39* P300_19829295_ChIP-Seq_ESCs_Human1.57029374
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55812510
41RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.53691082
42OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52970530
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51178854
44RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50622201
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49090364
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.47168492
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.46718856
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42969350
49EWS_26573619_Chip-Seq_HEK293_Human1.41774519
50BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41519115
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.40850080
52VDR_22108803_ChIP-Seq_LS180_Human1.40587355
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37855383
54FUS_26573619_Chip-Seq_HEK293_Human1.35573551
55IGF1R_20145208_ChIP-Seq_DFB_Human1.34044789
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33445771
57RNF2_27304074_Chip-Seq_NSC_Mouse1.33356391
58SALL1_21062744_ChIP-ChIP_HESCs_Human1.32979337
59* STAT3_23295773_ChIP-Seq_U87_Human1.30791173
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.29153494
61AR_25329375_ChIP-Seq_VCAP_Human1.28466450
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27244810
63NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23444765
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.22976540
65CBP_20019798_ChIP-Seq_JUKART_Human1.22580210
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.22580210
67* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20656937
68TP53_16413492_ChIP-PET_HCT116_Human1.20312673
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.20047218
70TAL1_26923725_Chip-Seq_HPCs_Mouse1.18292511
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16892727
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.16599186
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15984872
74ARNT_22903824_ChIP-Seq_MCF-7_Human1.15667331
75PRDM14_20953172_ChIP-Seq_ESCs_Human1.15348356
76* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15337742
77* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14463730
78ER_23166858_ChIP-Seq_MCF-7_Human1.13827474
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12765686
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.12564927
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12553078
82KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12462997
83* TCF4_23295773_ChIP-Seq_U87_Human1.11232214
84AHR_22903824_ChIP-Seq_MCF-7_Human1.10951062
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10548225
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10383398
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10383398
88RUNX2_22187159_ChIP-Seq_PCA_Human1.09531937
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.09306035
90KDM2B_26808549_Chip-Seq_REH_Human1.09118530
91* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08304729
92SOX9_26525672_Chip-Seq_HEART_Mouse1.07422241
93ZNF274_21170338_ChIP-Seq_K562_Hela1.06942433
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05942168
95* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05647796
96AR_19668381_ChIP-Seq_PC3_Human1.04463630
97EP300_21415370_ChIP-Seq_HL-1_Mouse1.04428551
98TP53_18474530_ChIP-ChIP_U2OS_Human1.03827713
99P53_22387025_ChIP-Seq_ESCs_Mouse1.03748460
100* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03469536
101MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03201931
102PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02140212
103RING1B_27294783_Chip-Seq_NPCs_Mouse1.01609069
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.01589115
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99699794
106TCF4_22108803_ChIP-Seq_LS180_Human0.98025564
107P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96840035
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96513656
109* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95811397
110JUN_21703547_ChIP-Seq_K562_Human0.95756964
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95163278
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.92724417
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.92088666
114ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91387642
115MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.91024329
116CMYC_18555785_Chip-Seq_ESCs_Mouse0.90738448
117BCAT_22108803_ChIP-Seq_LS180_Human0.90734313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.05325596
2MP0003880_abnormal_central_pattern4.67168315
3MP0004270_analgesia3.54744740
4MP0003635_abnormal_synaptic_transmissio3.45290242
5MP0009745_abnormal_behavioral_response2.96967271
6MP0002064_seizures2.84758152
7MP0002063_abnormal_learning/memory/cond2.82493047
8MP0001486_abnormal_startle_reflex2.70858011
9MP0002572_abnormal_emotion/affect_behav2.57132334
10MP0009046_muscle_twitch2.53228284
11MP0002272_abnormal_nervous_system2.52526379
12MP0002734_abnormal_mechanical_nocicepti2.38727773
13MP0000778_abnormal_nervous_system2.32923160
14MP0001968_abnormal_touch/_nociception2.30933301
15MP0001529_abnormal_vocalization2.22029966
16MP0005423_abnormal_somatic_nervous2.18409086
17MP0001440_abnormal_grooming_behavior2.10487826
18MP0003329_amyloid_beta_deposits2.02732634
19MP0002736_abnormal_nociception_after2.01730945
20MP0001905_abnormal_dopamine_level1.97414707
21MP0005646_abnormal_pituitary_gland1.94047055
22MP0001501_abnormal_sleep_pattern1.90324387
23MP0004885_abnormal_endolymph1.83770866
24MP0002822_catalepsy1.83286284
25MP0002067_abnormal_sensory_capabilities1.82663178
26MP0002735_abnormal_chemical_nociception1.82404585
27MP0001970_abnormal_pain_threshold1.72131174
28MP0000920_abnormal_myelination1.66858694
29MP0006276_abnormal_autonomic_nervous1.64734950
30MP0001984_abnormal_olfaction1.64068713
31MP0002733_abnormal_thermal_nociception1.62607904
32MP0002557_abnormal_social/conspecific_i1.62193696
33MP0002184_abnormal_innervation1.60811614
34MP0000569_abnormal_digit_pigmentation1.60525712
35MP0008569_lethality_at_weaning1.57624365
36MP0004742_abnormal_vestibular_system1.56830350
37MP0004133_heterotaxia1.48702600
38MP0002882_abnormal_neuron_morphology1.47756964
39MP0000955_abnormal_spinal_cord1.47010732
40MP0005386_behavior/neurological_phenoty1.46540973
41MP0004924_abnormal_behavior1.46540973
42MP0005171_absent_coat_pigmentation1.45827364
43MP0004145_abnormal_muscle_electrophysio1.45696654
44MP0009780_abnormal_chondrocyte_physiolo1.44416365
45MP0003690_abnormal_glial_cell1.43618022
46MP0004142_abnormal_muscle_tone1.37965378
47MP0003121_genomic_imprinting1.37091919
48MP0002066_abnormal_motor_capabilities/c1.35525082
49MP0000751_myopathy1.35156053
50MP0004858_abnormal_nervous_system1.34652542
51MP0001485_abnormal_pinna_reflex1.33111136
52MP0003787_abnormal_imprinting1.29078448
53MP0001188_hyperpigmentation1.27590923
54MP0001502_abnormal_circadian_rhythm1.26680677
55MP0003634_abnormal_glial_cell1.23986609
56MP0005645_abnormal_hypothalamus_physiol1.23242002
57MP0004811_abnormal_neuron_physiology1.22260280
58MP0003631_nervous_system_phenotype1.20746288
59MP0005623_abnormal_meninges_morphology1.20354059
60MP0000749_muscle_degeneration1.19778002
61MP0003632_abnormal_nervous_system1.18883484
62MP0002152_abnormal_brain_morphology1.17021656
63MP0001963_abnormal_hearing_physiology1.16159812
64MP0005253_abnormal_eye_physiology1.15303007
65MP0003633_abnormal_nervous_system1.14519676
66MP0002102_abnormal_ear_morphology1.14082849
67MP0005409_darkened_coat_color1.14000715
68MP0005248_abnormal_Harderian_gland1.12787353
69MP0005551_abnormal_eye_electrophysiolog1.09856281
70MP0003136_yellow_coat_color1.09768800
71MP0002837_dystrophic_cardiac_calcinosis1.05363358
72MP0002752_abnormal_somatic_nervous1.05266571
73MP0002653_abnormal_ependyma_morphology1.04920212
74MP0001986_abnormal_taste_sensitivity1.04010208
75MP0002751_abnormal_autonomic_nervous1.01842218
76MP0002229_neurodegeneration1.01604586
77MP0000631_abnormal_neuroendocrine_gland1.00331890
78MP0002234_abnormal_pharynx_morphology0.98701166
79MP0008789_abnormal_olfactory_epithelium0.97003419
80MP0005187_abnormal_penis_morphology0.93206079
81MP0000026_abnormal_inner_ear0.92940422
82MP0002909_abnormal_adrenal_gland0.91347619
83MP0001177_atelectasis0.89700810
84MP0003950_abnormal_plasma_membrane0.88826094
85MP0006072_abnormal_retinal_apoptosis0.85766323
86MP0010386_abnormal_urinary_bladder0.84609689
87MP0004084_abnormal_cardiac_muscle0.83915482
88MP0008877_abnormal_DNA_methylation0.83840136
89MP0005499_abnormal_olfactory_system0.83457582
90MP0005394_taste/olfaction_phenotype0.83457582
91MP0000049_abnormal_middle_ear0.82371766
92MP0005620_abnormal_muscle_contractility0.81776664
93MP0003879_abnormal_hair_cell0.81397158
94MP0004484_altered_response_of0.79365397
95MP0006292_abnormal_olfactory_placode0.78841420
96MP0000462_abnormal_digestive_system0.78658916
97MP0001299_abnormal_eye_distance/0.78436273
98MP0004215_abnormal_myocardial_fiber0.78273107
99MP0003938_abnormal_ear_development0.77227977
100MP0003861_abnormal_nervous_system0.77056822
101MP0004085_abnormal_heartbeat0.77038976
102MP0002069_abnormal_eating/drinking_beha0.76866216
103MP0005410_abnormal_fertilization0.75721584
104MP0004043_abnormal_pH_regulation0.75407035
105MP0002938_white_spotting0.74260763
106MP0003122_maternal_imprinting0.73176465
107MP0003137_abnormal_impulse_conducting0.71066418
108MP0000604_amyloidosis0.70798852
109MP0003646_muscle_fatigue0.66182099
110MP0000013_abnormal_adipose_tissue0.64798410
111MP0009250_abnormal_appendicular_skeleto0.64462033
112MP0002249_abnormal_larynx_morphology0.64390389
113MP0008874_decreased_physiological_sensi0.62993932
114MP0002638_abnormal_pupillary_reflex0.62378792
115MP0004233_abnormal_muscle_weight0.61922352
116MP0002295_abnormal_pulmonary_circulatio0.61887011
117MP0000566_synostosis0.60261066
118MP0005195_abnormal_posterior_eye0.58414350
119MP0001943_abnormal_respiration0.57571751

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.89965941
2Myokymia (HP:0002411)4.84088655
3Atonic seizures (HP:0010819)4.19615584
4Focal seizures (HP:0007359)4.16334461
5Neurofibrillary tangles (HP:0002185)4.08886121
6Epileptic encephalopathy (HP:0200134)4.08826519
7Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.73952395
8Degeneration of the lateral corticospinal tracts (HP:0002314)3.73952395
9Cerebral inclusion bodies (HP:0100314)3.53399163
10Febrile seizures (HP:0002373)3.47013102
11Hyperventilation (HP:0002883)3.27722793
12Abnormality of the corticospinal tract (HP:0002492)3.26147238
13Aplasia involving bones of the extremities (HP:0009825)3.25502099
14Aplasia involving bones of the upper limbs (HP:0009823)3.25502099
15Aplasia of the phalanges of the hand (HP:0009802)3.25502099
16True hermaphroditism (HP:0010459)3.25398082
17Progressive cerebellar ataxia (HP:0002073)3.06406331
18Broad-based gait (HP:0002136)2.99949973
19Pancreatic fibrosis (HP:0100732)2.99835914
20Dysmetria (HP:0001310)2.96686105
21Insidious onset (HP:0003587)2.95417083
22Termporal pattern (HP:0011008)2.95417083
23Molar tooth sign on MRI (HP:0002419)2.82871575
24Abnormality of midbrain morphology (HP:0002418)2.82871575
25Supranuclear gaze palsy (HP:0000605)2.82260236
26Action tremor (HP:0002345)2.77252962
27Generalized tonic-clonic seizures (HP:0002069)2.76372597
28Nephronophthisis (HP:0000090)2.69470920
29Dialeptic seizures (HP:0011146)2.68338104
30Absence seizures (HP:0002121)2.67859513
31Megalencephaly (HP:0001355)2.66680824
32Pancreatic cysts (HP:0001737)2.66057371
33Hemiparesis (HP:0001269)2.62033293
34Visual hallucinations (HP:0002367)2.60895970
35Ankle clonus (HP:0011448)2.58651242
36Gait imbalance (HP:0002141)2.53104822
37Dysdiadochokinesis (HP:0002075)2.50320268
38Spastic gait (HP:0002064)2.48704503
39Abnormal eating behavior (HP:0100738)2.44447713
40Gaze-evoked nystagmus (HP:0000640)2.41443978
41Amblyopia (HP:0000646)2.39775684
42Impaired vibration sensation in the lower limbs (HP:0002166)2.38316908
43Thickened helices (HP:0000391)2.34454692
44Peripheral hypomyelination (HP:0007182)2.32148855
45Excessive salivation (HP:0003781)2.31977741
46Drooling (HP:0002307)2.31977741
47Retinal dysplasia (HP:0007973)2.30861159
48Chronic hepatic failure (HP:0100626)2.29998653
49Truncal ataxia (HP:0002078)2.28982780
50Diplopia (HP:0000651)2.26509276
51Abnormality of binocular vision (HP:0011514)2.26509276
52Fetal akinesia sequence (HP:0001989)2.25145428
53Urinary bladder sphincter dysfunction (HP:0002839)2.24624656
54Scanning speech (HP:0002168)2.22033258
55Absent speech (HP:0001344)2.21717309
56Lissencephaly (HP:0001339)2.20877822
57Medial flaring of the eyebrow (HP:0010747)2.20467756
58Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.19756429
59Congenital primary aphakia (HP:0007707)2.19431975
60Abnormal hair whorl (HP:0010721)2.19108478
61Genital tract atresia (HP:0001827)2.19095156
62Absent/shortened dynein arms (HP:0200106)2.17284011
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.17284011
64Vaginal atresia (HP:0000148)2.16198625
65Lower limb muscle weakness (HP:0007340)2.15878068
66Abnormality of the renal medulla (HP:0100957)2.15276893
67Limb dystonia (HP:0002451)2.14631393
68Polyphagia (HP:0002591)2.12705078
69Mutism (HP:0002300)2.09831748
70Pachygyria (HP:0001302)2.09361118
71Ulnar claw (HP:0001178)2.09359446
72Abnormal respiratory motile cilium physiology (HP:0012261)2.08213212
73Abnormal ciliary motility (HP:0012262)2.07339403
74Optic nerve hypoplasia (HP:0000609)2.06062077
75Intention tremor (HP:0002080)2.05988118
76Specific learning disability (HP:0001328)2.04078367
77Postaxial hand polydactyly (HP:0001162)2.03999282
78Exercise-induced muscle cramps (HP:0003710)2.02894250
79Anxiety (HP:0000739)2.02412651
80Type II lissencephaly (HP:0007260)2.02120843
81Nephrogenic diabetes insipidus (HP:0009806)2.00742693
82Abnormality of the labia minora (HP:0012880)2.00227088
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.99958094
84Genetic anticipation (HP:0003743)1.99206277
85Sensory axonal neuropathy (HP:0003390)1.98327695
86Epileptiform EEG discharges (HP:0011182)1.97025909
87Hepatoblastoma (HP:0002884)1.96523880
88Generalized myoclonic seizures (HP:0002123)1.94607314
89Urinary urgency (HP:0000012)1.90721189
90Pheochromocytoma (HP:0002666)1.88775984
91Clumsiness (HP:0002312)1.87491221
92EEG with generalized epileptiform discharges (HP:0011198)1.84000782
93Hypoplastic nipples (HP:0002557)1.83310244
94Papillary thyroid carcinoma (HP:0002895)1.83294605
95Neuroendocrine neoplasm (HP:0100634)1.83137814
96Broad foot (HP:0001769)1.82702873
97Cystic liver disease (HP:0006706)1.82518575
98Split foot (HP:0001839)1.82343207
99Occipital encephalocele (HP:0002085)1.82309087
100Sleep apnea (HP:0010535)1.82160061
101Postaxial foot polydactyly (HP:0001830)1.82059316
102Muscle hypertrophy of the lower extremities (HP:0008968)1.80740892
103Spastic tetraplegia (HP:0002510)1.80505126
104Torticollis (HP:0000473)1.80431970
105Anosmia (HP:0000458)1.80166762
106Abnormal respiratory motile cilium morphology (HP:0005938)1.80017737
107Abnormal respiratory epithelium morphology (HP:0012253)1.80017737
108Depression (HP:0000716)1.79747085
109Calf muscle hypertrophy (HP:0008981)1.79490902
110Delusions (HP:0000746)1.79372485
111Left ventricular hypertrophy (HP:0001712)1.78787356
112Progressive inability to walk (HP:0002505)1.78221687
113Aplasia/Hypoplasia of the tibia (HP:0005772)1.77420471
114Sclerocornea (HP:0000647)1.75691279
115Narrow nasal bridge (HP:0000446)1.75656715
116Status epilepticus (HP:0002133)1.75030741
117Narrow forehead (HP:0000341)1.74976931
118Protruding tongue (HP:0010808)1.74645421
119Rimmed vacuoles (HP:0003805)1.74067145
120Poor eye contact (HP:0000817)1.73688354
121Amyotrophic lateral sclerosis (HP:0007354)1.73414650
122Hypsarrhythmia (HP:0002521)1.72865579
123Abnormality of salivation (HP:0100755)1.72737793
124Aplasia/Hypoplasia of the lens (HP:0008063)1.72448724
125Muscle fiber inclusion bodies (HP:0100299)1.71070574
126Cutaneous finger syndactyly (HP:0010554)1.69856743
127Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.69559199
128Intellectual disability, moderate (HP:0002342)1.69277227
129Anencephaly (HP:0002323)1.69191278
130Abnormality of the calf musculature (HP:0001430)1.69154910
131Widely spaced teeth (HP:0000687)1.68969210
132Alacrima (HP:0000522)1.68900165
133Myotonia (HP:0002486)1.68290213
134Akinesia (HP:0002304)1.67164030
135Blue irides (HP:0000635)1.66722643
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.65910078
137Morphological abnormality of the pyramidal tract (HP:0002062)1.65642757
138Postural instability (HP:0002172)1.65364717
139Arterial tortuosity (HP:0005116)1.65058256
140Inability to walk (HP:0002540)1.64978854
141Morphological abnormality of the inner ear (HP:0011390)1.61762888
142Poor coordination (HP:0002370)1.61466362
143Gait ataxia (HP:0002066)1.61078591
144Hypoplastic left heart (HP:0004383)1.61031377
145Impaired social interactions (HP:0000735)1.60250519
146Abnormal social behavior (HP:0012433)1.60250519
147Esotropia (HP:0000565)1.59926844
148Abnormality of glycolysis (HP:0004366)1.59778832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.40062324
2CASK3.52572527
3NTRK33.39802026
4MAP4K22.79654130
5MAP3K42.46426446
6MAP3K92.43372300
7WNK32.37708843
8MARK12.27079066
9TNIK2.25494652
10MAP2K72.25377099
11FRK2.03268495
12OXSR12.03065582
13NTRK22.01511140
14OBSCN2.00559120
15MAPK132.00370703
16PRPF4B1.96176151
17PRKD31.94580150
18TYRO31.92456733
19STK391.91254976
20MINK11.91189789
21PAK61.90576542
22PNCK1.72327948
23KSR21.64760380
24PLK21.64031182
25PINK11.63670396
26ARAF1.60410799
27MAP2K41.57122555
28NTRK11.49071701
29PHKG21.42818141
30PHKG11.42818141
31BMPR21.40947094
32KSR11.38250626
33MAP3K121.34587916
34CDK51.28658686
35DAPK21.28085414
36SGK4941.27072080
37SGK2231.27072080
38CAMK2B1.26298718
39FES1.25745452
40ERBB31.24600259
41MAP3K131.24506802
42BCR1.23859537
43CAMK2A1.22093255
44FGR1.19404449
45MUSK1.19334590
46EPHA31.16774371
47MAP3K61.16203824
48CDK191.14758797
49PKN11.11042139
50CAMKK21.10527207
51PTK2B1.10089542
52UHMK11.08471818
53TRIM281.06976299
54MAPKAPK51.03576022
55GRK51.02433583
56NEK60.99191932
57LATS20.97047751
58PRKCG0.94362694
59STK38L0.93596522
60ROCK20.92146107
61FGFR20.91469716
62MOS0.91126770
63PAK30.91085923
64MAPK150.89650949
65CDK180.87460052
66CSNK1G20.85709786
67CDK150.84690913
68CAMK2D0.83063913
69BRAF0.82030286
70ERBB40.81474274
71CAMK10.81331532
72CDK140.80518715
73EPHB20.78680233
74MARK20.77686891
75DYRK20.77678041
76DYRK1A0.77420565
77ADRBK20.77144693
78PRKCE0.76289416
79LMTK20.75997314
80RAF10.74745365
81INSRR0.72619172
82CDK11A0.71876821
83AKT30.70326002
84CAMK2G0.69126868
85DMPK0.68445892
86RIPK40.67090793
87SGK20.66374665
88CAMK40.65956794
89CSNK1G30.65313710
90CCNB10.63387106
91DDR20.62933710
92DYRK1B0.62303874
93BMPR1B0.60739975
94PRKCH0.60272821
95CSNK1A1L0.59403192
96DYRK30.58593301
97SGK10.57978411
98MKNK20.57127346
99CAMK1G0.56257271
100PRKCZ0.54279633
101GRK10.54047124
102PIK3CA0.53487572
103WNK40.53411577
104TIE10.53085847
105SIK20.51598519
106STK380.49155520
107CSNK1G10.49049615
108DAPK10.48777491
109RET0.47825072
110PRKAA10.47422820
111CAMKK10.46717198
112MAP3K70.45747373
113STK110.43205544
114PDPK10.43160741
115TNK20.42921240
116ROCK10.42417709
117FYN0.42126196
118NME10.41691203
119ADRBK10.41564934
120WNK10.41376277
121ERBB20.41246119
122CDK30.40298220
123PRKACB0.39087595
124PRKG10.38909219
125MAPK120.38587907
126PRKD20.38096606
127GRK70.37371367
128RPS6KA30.37090405
129CSNK1D0.36850069
130PRKACA0.35369467
131LIMK10.35206688
132CSNK1A10.34937705
133TAOK30.33938248
134SGK30.33734697
135MAPK100.33221257

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.62903589
2Glutamatergic synapse_Homo sapiens_hsa047242.82675094
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71125672
4GABAergic synapse_Homo sapiens_hsa047272.58286898
5Synaptic vesicle cycle_Homo sapiens_hsa047212.55389362
6Circadian entrainment_Homo sapiens_hsa047132.44920497
7Morphine addiction_Homo sapiens_hsa050322.34093769
8Olfactory transduction_Homo sapiens_hsa047402.27443574
9Long-term potentiation_Homo sapiens_hsa047202.22660657
10Amphetamine addiction_Homo sapiens_hsa050312.05339691
11Salivary secretion_Homo sapiens_hsa049702.00171002
12Serotonergic synapse_Homo sapiens_hsa047261.99180327
13Dopaminergic synapse_Homo sapiens_hsa047281.95328947
14Long-term depression_Homo sapiens_hsa047301.89647193
15Collecting duct acid secretion_Homo sapiens_hsa049661.85829091
16Cholinergic synapse_Homo sapiens_hsa047251.77616718
17Taste transduction_Homo sapiens_hsa047421.73446602
18Gastric acid secretion_Homo sapiens_hsa049711.70331602
19Butanoate metabolism_Homo sapiens_hsa006501.68679549
20Axon guidance_Homo sapiens_hsa043601.67420032
21Cocaine addiction_Homo sapiens_hsa050301.63127998
22Insulin secretion_Homo sapiens_hsa049111.62523025
23Renin secretion_Homo sapiens_hsa049241.47898276
24GnRH signaling pathway_Homo sapiens_hsa049121.47162380
25Oxytocin signaling pathway_Homo sapiens_hsa049211.45899776
26Calcium signaling pathway_Homo sapiens_hsa040201.45381328
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.45195872
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44695941
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37463751
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35161791
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.28260498
32Gap junction_Homo sapiens_hsa045401.26172164
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23380031
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20828603
35beta-Alanine metabolism_Homo sapiens_hsa004101.18101161
36Propanoate metabolism_Homo sapiens_hsa006401.17777155
37cAMP signaling pathway_Homo sapiens_hsa040241.16717066
38Nitrogen metabolism_Homo sapiens_hsa009101.16306137
39Vibrio cholerae infection_Homo sapiens_hsa051101.13842347
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13538428
41Ether lipid metabolism_Homo sapiens_hsa005651.12396785
42Vascular smooth muscle contraction_Homo sapiens_hsa042701.11655059
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11232855
44Histidine metabolism_Homo sapiens_hsa003401.10391310
45Melanogenesis_Homo sapiens_hsa049161.06194427
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05183989
47Phototransduction_Homo sapiens_hsa047441.04258118
48Cardiac muscle contraction_Homo sapiens_hsa042601.03584049
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02154764
50Oxidative phosphorylation_Homo sapiens_hsa001901.01891142
51ErbB signaling pathway_Homo sapiens_hsa040121.01257790
52Dorso-ventral axis formation_Homo sapiens_hsa043201.01057504
53Ovarian steroidogenesis_Homo sapiens_hsa049130.99123851
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.98401215
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96079516
56Estrogen signaling pathway_Homo sapiens_hsa049150.95221895
57Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93745099
58Phospholipase D signaling pathway_Homo sapiens_hsa040720.92532793
59Alzheimers disease_Homo sapiens_hsa050100.89518656
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.87811362
61Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.87737001
62Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87295695
63ABC transporters_Homo sapiens_hsa020100.86914128
64Choline metabolism in cancer_Homo sapiens_hsa052310.86624840
65Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85751905
66Ras signaling pathway_Homo sapiens_hsa040140.85694214
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84627000
68Dilated cardiomyopathy_Homo sapiens_hsa054140.75986742
69Pancreatic secretion_Homo sapiens_hsa049720.75096684
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74642444
71Protein export_Homo sapiens_hsa030600.74443838
72Glioma_Homo sapiens_hsa052140.73258540
73Oocyte meiosis_Homo sapiens_hsa041140.73069298
74Regulation of autophagy_Homo sapiens_hsa041400.72865151
75Circadian rhythm_Homo sapiens_hsa047100.72746441
76Tryptophan metabolism_Homo sapiens_hsa003800.72238254
77Linoleic acid metabolism_Homo sapiens_hsa005910.71666297
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.70156957
79Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70047439
80Renal cell carcinoma_Homo sapiens_hsa052110.69953417
81Arginine and proline metabolism_Homo sapiens_hsa003300.68536794
82Hippo signaling pathway_Homo sapiens_hsa043900.67107181
83MAPK signaling pathway_Homo sapiens_hsa040100.66034840
84Basal cell carcinoma_Homo sapiens_hsa052170.65326268
85Fatty acid biosynthesis_Homo sapiens_hsa000610.64268926
86Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62703977
87Fatty acid elongation_Homo sapiens_hsa000620.61297623
88Wnt signaling pathway_Homo sapiens_hsa043100.60924456
89Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60560553
90Rap1 signaling pathway_Homo sapiens_hsa040150.58981390
91Bile secretion_Homo sapiens_hsa049760.57974077
92Thyroid hormone synthesis_Homo sapiens_hsa049180.56119910
93Primary bile acid biosynthesis_Homo sapiens_hsa001200.55697816
94Peroxisome_Homo sapiens_hsa041460.55327132
95Vitamin B6 metabolism_Homo sapiens_hsa007500.54282826
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53061035
97Steroid biosynthesis_Homo sapiens_hsa001000.51974534
98Parkinsons disease_Homo sapiens_hsa050120.51398489
99Rheumatoid arthritis_Homo sapiens_hsa053230.51000669
100VEGF signaling pathway_Homo sapiens_hsa043700.49957548
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49694317
102Type II diabetes mellitus_Homo sapiens_hsa049300.49264651
103Hedgehog signaling pathway_Homo sapiens_hsa043400.48533085
104Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.48385923
105Tight junction_Homo sapiens_hsa045300.48033527
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47257280
107AMPK signaling pathway_Homo sapiens_hsa041520.46573988
108Fatty acid metabolism_Homo sapiens_hsa012120.45793234
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.45607013
110Huntingtons disease_Homo sapiens_hsa050160.45159118
111Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.44111776
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43430745
113Basal transcription factors_Homo sapiens_hsa030220.42673776
114African trypanosomiasis_Homo sapiens_hsa051430.42477117
115Sphingolipid metabolism_Homo sapiens_hsa006000.40231472
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40209288
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39487968
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39212902
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.38500375
120Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37469713
121Inositol phosphate metabolism_Homo sapiens_hsa005620.37238744
122Endocytosis_Homo sapiens_hsa041440.36360139
123Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.35185619
124Prion diseases_Homo sapiens_hsa050200.34468619
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33080807
126Glucagon signaling pathway_Homo sapiens_hsa049220.33070655
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.31360098
128Alcoholism_Homo sapiens_hsa050340.31057616

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