FAM150A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)8.89850314
2cell adhesion mediated by integrin (GO:0033627)7.64552065
3wound healing, spreading of epidermal cells (GO:0035313)6.85910208
4wound healing, spreading of cells (GO:0044319)6.03975047
5sequestering of extracellular ligand from receptor (GO:0035581)5.72350477
6collagen fibril organization (GO:0030199)5.67825563
7positive regulation of endothelial cell apoptotic process (GO:2000353)5.63324844
8endodermal cell differentiation (GO:0035987)5.59978072
9regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)5.58289642
10lymph vessel development (GO:0001945)5.55894575
11negative regulation of fatty acid transport (GO:2000192)5.51754178
12negative regulation of fibrinolysis (GO:0051918)5.23297704
13ribosome assembly (GO:0042255)5.05901478
14regulation of plasminogen activation (GO:0010755)4.98788434
15endocardial cushion development (GO:0003197)4.92404956
16protein neddylation (GO:0045116)4.84503228
17positive regulation of macrophage activation (GO:0043032)4.83983101
18regulation of tight junction assembly (GO:2000810)4.78242490
19regulation of ER to Golgi vesicle-mediated transport (GO:0060628)4.65094787
20DNA replication checkpoint (GO:0000076)4.64801745
21regulation of nuclear cell cycle DNA replication (GO:0033262)4.58049028
22regulation of G0 to G1 transition (GO:0070316)4.57124662
23positive regulation of osteoblast proliferation (GO:0033690)4.55358761
24outer ear morphogenesis (GO:0042473)4.52024788
25response to pheromone (GO:0019236)4.44431206
26actin filament depolymerization (GO:0030042)4.36676639
27stress fiber assembly (GO:0043149)4.34762928
28plasma membrane repair (GO:0001778)4.30608871
29substrate-dependent cell migration (GO:0006929)4.26880330
30epithelial cell-cell adhesion (GO:0090136)4.26501356
31positive regulation of fibroblast migration (GO:0010763)4.21650507
32positive regulation of blood vessel endothelial cell migration (GO:0043536)4.21644767
33heterochromatin organization (GO:0070828)4.21308136
34embryonic heart tube development (GO:0035050)4.15626396
35regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.14288591
36negative regulation of adherens junction organization (GO:1903392)3.94286792
37negative regulation of focal adhesion assembly (GO:0051895)3.94286792
38negative regulation of cell junction assembly (GO:1901889)3.94286792
39epoxygenase P450 pathway (GO:0019373)3.94061217
40tooth mineralization (GO:0034505)3.92156522
41regulation of double-strand break repair via homologous recombination (GO:0010569)3.91882565
42craniofacial suture morphogenesis (GO:0097094)3.89700088
43cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.87556955
44transcription from mitochondrial promoter (GO:0006390)3.87008113
45protein localization to cell surface (GO:0034394)3.82498705
46regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.77778085
47axon extension involved in axon guidance (GO:0048846)3.71534592
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.71534592
49dermatan sulfate biosynthetic process (GO:0030208)3.67305848
50protein-cofactor linkage (GO:0018065)3.65639990
51cellular response to vitamin D (GO:0071305)3.63887556
52positive regulation of epithelial to mesenchymal transition (GO:0010718)3.62265216
53regulation of integrin-mediated signaling pathway (GO:2001044)3.60343051
54rRNA transcription (GO:0009303)3.59865672
55mesodermal cell differentiation (GO:0048333)3.59357025
56mesenchymal-epithelial cell signaling (GO:0060638)3.57363136
57cell migration involved in sprouting angiogenesis (GO:0002042)3.56230902
58adherens junction assembly (GO:0034333)3.56015612
59cranial suture morphogenesis (GO:0060363)3.55471047
60gastrulation with mouth forming second (GO:0001702)3.54525857
61negative regulation of anoikis (GO:2000811)3.52757946
62leukotriene biosynthetic process (GO:0019370)3.52327231
63peptidyl-arginine omega-N-methylation (GO:0035247)3.51436614
64glutathione biosynthetic process (GO:0006750)3.51280839
65positive regulation of collagen biosynthetic process (GO:0032967)3.50891571
66apoptotic cell clearance (GO:0043277)3.50236016
67proteasome assembly (GO:0043248)3.49338020
68regulation of transforming growth factor beta1 production (GO:0032908)3.48855190
69skin morphogenesis (GO:0043589)3.48402035
70regulation of fibrinolysis (GO:0051917)3.47391691
71omega-hydroxylase P450 pathway (GO:0097267)3.45817299
72prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.45713714
73protein retention in ER lumen (GO:0006621)3.45406720
74platelet aggregation (GO:0070527)3.45367179
75positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)3.44621134
76maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.42624283
77protein complex localization (GO:0031503)3.42401554
78substrate adhesion-dependent cell spreading (GO:0034446)3.41036474
79histone arginine methylation (GO:0034969)3.40697640
80positive regulation of cell size (GO:0045793)3.39388517
81platelet degranulation (GO:0002576)3.38880576
82maturation of SSU-rRNA (GO:0030490)3.37324292
83outflow tract septum morphogenesis (GO:0003148)3.33799556
84cellular response to interferon-alpha (GO:0035457)3.33507387
85regulation of mammary gland epithelial cell proliferation (GO:0033599)3.33487682
86embryonic skeletal joint morphogenesis (GO:0060272)3.32723317
87protein K6-linked ubiquitination (GO:0085020)3.31085874
88positive regulation of collagen metabolic process (GO:0010714)3.30821650
89hippo signaling (GO:0035329)3.29346148
90negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.28953974
91protein heterotrimerization (GO:0070208)3.28684872
92mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.27755047
93dermatan sulfate metabolic process (GO:0030205)3.27569437
94nonribosomal peptide biosynthetic process (GO:0019184)3.27034301
95negative regulation by host of viral transcription (GO:0043922)3.26943708
96cellular protein complex localization (GO:0034629)3.26749854
97positive regulation of actin filament depolymerization (GO:0030836)3.26535005
98regulation of hippo signaling (GO:0035330)3.26489066
99regulation of monocyte chemotaxis (GO:0090025)3.24608560
100establishment of monopolar cell polarity (GO:0061162)3.21345127
101establishment or maintenance of monopolar cell polarity (GO:0061339)3.21345127
102COPI coating of Golgi vesicle (GO:0048205)3.20943985
103Golgi transport vesicle coating (GO:0048200)3.20943985
104regulation of collagen metabolic process (GO:0010712)3.20660619
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.20654824
106cell-substrate junction assembly (GO:0007044)3.20350330
107metanephric mesenchyme development (GO:0072075)3.19380241
108cellular response to vitamin (GO:0071295)3.18855403
109negative regulation of smooth muscle cell migration (GO:0014912)3.18676299
110maturation of 5.8S rRNA (GO:0000460)3.17942080
111negative regulation of catenin import into nucleus (GO:0035414)3.16752762
112retina vasculature morphogenesis in camera-type eye (GO:0061299)3.13580773
113negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.13017861
114planar cell polarity pathway involved in neural tube closure (GO:0090179)3.12441879
115fibril organization (GO:0097435)3.11904006
116negative regulation of viral transcription (GO:0032897)3.11872685
117regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09263691
118bone trabecula formation (GO:0060346)3.08213094
119regulation of response to osmotic stress (GO:0047484)3.08031162
120regulation of collagen biosynthetic process (GO:0032965)3.06937589
121positive regulation of guanylate cyclase activity (GO:0031284)3.06326407
122kidney mesenchyme development (GO:0072074)3.05343719
123extracellular fibril organization (GO:0043206)3.05164201
124vascular endothelial growth factor signaling pathway (GO:0038084)3.03907880
125negative regulation of cell-matrix adhesion (GO:0001953)3.03880317
126peptidyl-proline hydroxylation (GO:0019511)3.03701677
127postreplication repair (GO:0006301)3.02124255
128positive regulation of hemostasis (GO:1900048)3.01859720
129positive regulation of blood coagulation (GO:0030194)3.01859720
130positive regulation of monocyte chemotaxis (GO:0090026)3.00911998
131extracellular regulation of signal transduction (GO:1900115)3.00625388
132extracellular negative regulation of signal transduction (GO:1900116)3.00625388
133diaphragm development (GO:0060539)2.99593866
134regulation of macrophage chemotaxis (GO:0010758)2.98970590
135regulation of mitochondrial translation (GO:0070129)2.98150820
136peripheral nervous system neuron development (GO:0048935)2.97163396
137proximal/distal pattern formation (GO:0009954)2.96001317
138cell migration in hindbrain (GO:0021535)2.94768643
139negative regulation of chondrocyte differentiation (GO:0032331)2.94581408
140response to laminar fluid shear stress (GO:0034616)2.94144327
141protein K63-linked ubiquitination (GO:0070534)2.93744924
142basement membrane organization (GO:0071711)2.93151059
143lymphangiogenesis (GO:0001946)2.92665741
144phagocytosis, engulfment (GO:0006911)2.91286112
145DNA strand elongation involved in DNA replication (GO:0006271)2.91250501
146establishment of apical/basal cell polarity (GO:0035089)2.90987673
147DNA unwinding involved in DNA replication (GO:0006268)2.90673067
148negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.89884765
149blood vessel endothelial cell migration (GO:0043534)2.89252228
150thyroid gland development (GO:0030878)2.89232651
151establishment of tissue polarity (GO:0007164)2.89094571
152establishment of planar polarity (GO:0001736)2.89094571
153peptidyl-arginine N-methylation (GO:0035246)2.88888410
154peptidyl-arginine methylation (GO:0018216)2.88888410
155ventricular cardiac muscle cell development (GO:0055015)2.87957175
156regulation of apoptotic process involved in morphogenesis (GO:1902337)2.86947687
157telomere maintenance via telomerase (GO:0007004)2.83908475
158focal adhesion assembly (GO:0048041)2.83712269
159cell-substrate adherens junction assembly (GO:0007045)2.83712269
160regulation of cellular respiration (GO:0043457)2.82394848
161collagen metabolic process (GO:0032963)2.82394126
162heterotypic cell-cell adhesion (GO:0034113)2.82123751
163DNA replication initiation (GO:0006270)2.80017152
164negative regulation of RNA splicing (GO:0033119)2.79836302
165muscle cell fate commitment (GO:0042693)2.79566201
166translesion synthesis (GO:0019985)2.78471688
167peptide biosynthetic process (GO:0043043)2.77159888
168DNA strand elongation (GO:0022616)2.75548908
169viral mRNA export from host cell nucleus (GO:0046784)2.74246455
170DNA damage response, detection of DNA damage (GO:0042769)2.73474280
171regulation of guanylate cyclase activity (GO:0031282)2.72289551
172convergent extension (GO:0060026)2.69734865
173termination of RNA polymerase II transcription (GO:0006369)2.69563357
174serine family amino acid biosynthetic process (GO:0009070)2.67631053
175negative regulation of DNA-templated transcription, elongation (GO:0032785)2.67256628
176negative regulation of mRNA processing (GO:0050686)2.66692249
177ventricular trabecula myocardium morphogenesis (GO:0003222)2.66547393
178regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.66530143
179ribosomal small subunit biogenesis (GO:0042274)2.65031790
180L-serine metabolic process (GO:0006563)2.63822104
181respiratory tube development (GO:0030323)2.63771691
182sulfur amino acid biosynthetic process (GO:0000097)2.62784400
183regulation of transcription from RNA polymerase I promoter (GO:0006356)2.62738636
184regulation of glucocorticoid metabolic process (GO:0031943)2.61810440
185regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.60732135
186fatty acid derivative biosynthetic process (GO:1901570)2.59772176
187icosanoid biosynthetic process (GO:0046456)2.59772176
188cysteine metabolic process (GO:0006534)2.59130485
189somatic stem cell division (GO:0048103)2.58526182
190mitochondrial RNA metabolic process (GO:0000959)2.58459523
191neuron fate specification (GO:0048665)2.58396537
192regulation of glucocorticoid secretion (GO:2000849)2.57751457
193regulation of cardioblast differentiation (GO:0051890)2.57406200
194positive regulation of RNA splicing (GO:0033120)2.55499458
195mammary gland epithelial cell differentiation (GO:0060644)2.54006800
196skeletal muscle organ development (GO:0060538)2.52536344

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.96811102
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.55605690
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.07225020
4E2F7_22180533_ChIP-Seq_HELA_Human4.82536284
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.67100820
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.66144644
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.63403560
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58113344
9RUNX2_24764292_ChIP-Seq_MC3T3_Mouse3.28376063
10XRN2_22483619_ChIP-Seq_HELA_Human2.99798340
11CLOCK_20551151_ChIP-Seq_293T_Human2.93442550
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.92276956
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.85441101
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.83489233
15SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.81687997
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.78167119
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.74071110
18TP63_19390658_ChIP-ChIP_HaCaT_Human2.72234405
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.58731870
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.58582674
21CJUN_26792858_Chip-Seq_BT549_Human2.57542229
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.55705574
23CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.55204705
24BRD4_25478319_ChIP-Seq_HGPS_Human2.50647607
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.42717452
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.42356576
27THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41662997
28CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.33600178
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.33329681
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.27962186
31SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.27292048
32SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.27292048
33WT1_19549856_ChIP-ChIP_CCG9911_Human2.26414764
34TTF2_22483619_ChIP-Seq_HELA_Human2.26259284
35CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.26052170
36EGR1_19374776_ChIP-ChIP_THP-1_Human2.21974957
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.18496835
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.18192118
39NRF2_20460467_ChIP-Seq_MEFs_Mouse2.18192118
40EP300_21415370_ChIP-Seq_HL-1_Mouse2.17690372
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.16509681
42KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.14342803
43NELFA_20434984_ChIP-Seq_ESCs_Mouse2.10381499
44SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.05222244
45E2F1_21310950_ChIP-Seq_MCF-7_Human2.02887685
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00310624
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.98073440
48DCP1A_22483619_ChIP-Seq_HELA_Human1.97640350
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.96867732
50HIF1A_21447827_ChIP-Seq_MCF-7_Human1.95799760
51GABP_19822575_ChIP-Seq_HepG2_Human1.90277971
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.88376787
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.86517965
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.86053852
55MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.85565138
56EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.84116554
57ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.81435250
58SOX2_20726797_ChIP-Seq_SW620_Human1.80807961
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.80418456
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.80294480
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.80129324
62ELK1_22589737_ChIP-Seq_MCF10A_Human1.78339885
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76876823
64JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.76482926
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.75370355
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75225449
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.72719279
68TP53_16413492_ChIP-PET_HCT116_Human1.70188730
69MYCN_18555785_ChIP-Seq_MESCs_Mouse1.70038125
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69742424
71TP53_18474530_ChIP-ChIP_U2OS_Human1.69600480
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69525413
73SALL4_18804426_ChIP-ChIP_XEN_Mouse1.68914508
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68143363
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66120144
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.65754701
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.63338332
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.62063741
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.60503825
80GABP_17652178_ChIP-ChIP_JURKAT_Human1.60115067
81POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.59789856
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.59714762
83TP53_22127205_ChIP-Seq_IMR90_Human1.59583823
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.57456248
85MYC_18940864_ChIP-ChIP_HL60_Human1.56872184
86ATF3_27146783_Chip-Seq_COLON_Human1.55998236
87TP53_23651856_ChIP-Seq_MEFs_Mouse1.55529670
88JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55380962
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.54845974
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.53519351
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53110697
92EZH2_27304074_Chip-Seq_ESCs_Mouse1.52705066
93P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52641667
94EST1_17652178_ChIP-ChIP_JURKAT_Human1.52430480
95ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.50943831
96NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48890317
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.48203494
98PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.48019427
99NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44831467
100FOXM1_23109430_ChIP-Seq_U2OS_Human1.43794688
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.43784440
102KDM5A_27292631_Chip-Seq_BREAST_Human1.43300148
103PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41657271
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.40749757
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.39720099
106ESR2_21235772_ChIP-Seq_MCF-7_Human1.37074934
107KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36303231
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35850149
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35850149
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35850149
111MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35523282
112CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34319064
113YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33729160
114FOXO3_23340844_ChIP-Seq_DLD1_Human1.33564021
115TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.32942391
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30007337
117ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29794932
118RNF2_27304074_Chip-Seq_NSC_Mouse1.28898201
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27638861
120CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27145596
121P68_20966046_ChIP-Seq_HELA_Human1.24015844
122E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23720078
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.23478334
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22894890
125UBF1/2_26484160_Chip-Seq_HMECs_Human1.22223642
126YY1_21170310_ChIP-Seq_MESCs_Mouse1.22066686
127SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21696229
128CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.21657802
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21097836
130JARID2_20064375_ChIP-Seq_MESCs_Mouse1.20364921
131EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.18818078
132MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.18723128
133UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17617173
134JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14487965
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.14327532
136POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14098458
137FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13292530
138FOXP1_21924763_ChIP-Seq_HESCs_Human1.13285263
139DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12362520
140REST_19997604_ChIP-ChIP_NEURONS_Mouse1.12350641
141TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11785692
142PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.11495650
143SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10816689
144NFI_21473784_ChIP-Seq_ESCs_Mouse1.10586625
145BP1_19119308_ChIP-ChIP_Hs578T_Human1.10045927
146RING1B_27294783_Chip-Seq_NPCs_Mouse1.09615976
147TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09270703
148KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07869243
149EWS_26573619_Chip-Seq_HEK293_Human1.07649660
150CTCF_27219007_Chip-Seq_Bcells_Human1.07648557
151EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06383875
152RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06383875
153EOMES_21245162_ChIP-Seq_HESCs_Human1.04022648
154NANOG_16153702_ChIP-ChIP_HESCs_Human1.03159874
155RACK7_27058665_Chip-Seq_MCF-7_Human1.02780498
156ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02433963
157ELK1_19687146_ChIP-ChIP_HELA_Human1.01964287
158CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.01439263
159ZNF217_24962896_ChIP-Seq_MCF-7_Human1.01288462
160AR_21909140_ChIP-Seq_LNCAP_Human1.00475749
161POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00338262
162TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00200323
163MYC_22102868_ChIP-Seq_BL_Human0.99443379
164ESR1_21235772_ChIP-Seq_MCF-7_Human0.98522100
165SA1_22415368_ChIP-Seq_MEFs_Mouse0.98445611
166P63_26484246_Chip-Seq_KERATINOCYTES_Human0.96672827
167ELF1_20517297_ChIP-Seq_JURKAT_Human0.96154738
168SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.96091143
169SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95710508
170FOXP3_21729870_ChIP-Seq_TREG_Human0.94273459
171VDR_21846776_ChIP-Seq_THP-1_Human0.93470640
172TET1_21451524_ChIP-Seq_MESCs_Mouse0.93157666
173KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93091661
174STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.92117677
175ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90799731
176GATA2_21666600_ChIP-Seq_HMVEC_Human0.88132327
177TBX20_22080862_ChIP-Seq_HEART_Mouse0.87400222
178TBX20_22328084_ChIP-Seq_HEART_Mouse0.87400222
179JUN_21703547_ChIP-Seq_K562_Human0.85763409
180RXR_22108803_ChIP-Seq_LS180_Human0.84934178
181SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83034390
182KLF5_25053715_ChIP-Seq_YYC3_Human0.82113673
183TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82081533
184ZFP281_27345836_Chip-Seq_ESCs_Mouse0.81367341
185TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80479118
186* TP63_23658742_ChIP-Seq_EP156T_Human0.79710075
187KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.78571502
188TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.78048437
189EED_16625203_ChIP-ChIP_MESCs_Mouse0.75684531

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.73426034
2MP0005623_abnormal_meninges_morphology4.84470250
3MP0005275_abnormal_skin_tensile4.16869090
4MP0001188_hyperpigmentation4.16828272
5MP0010352_gastrointestinal_tract_polyps4.12399184
6MP0003279_aneurysm3.99254863
7MP0004858_abnormal_nervous_system3.82231308
8MP0003693_abnormal_embryo_hatching3.77416356
9MP0003705_abnormal_hypodermis_morpholog3.72410088
10MP0003566_abnormal_cell_adhesion3.62769032
11MP0001346_abnormal_lacrimal_gland3.59741273
12MP0005503_abnormal_tendon_morphology3.27490803
13MP0001958_emphysema3.20721281
14MP0002249_abnormal_larynx_morphology3.06301708
15MP0003111_abnormal_nucleus_morphology2.84729369
16MP0009384_cardiac_valve_regurgitation2.60312385
17MP0003091_abnormal_cell_migration2.59471997
18MP0001348_abnormal_lacrimal_gland2.55857846
19MP0004272_abnormal_basement_membrane2.55832495
20MP0010094_abnormal_chromosome_stability2.55295735
21MP0002295_abnormal_pulmonary_circulatio2.50233094
22MP0005023_abnormal_wound_healing2.48440158
23MP0002163_abnormal_gland_morphology2.40410729
24MP0010030_abnormal_orbit_morphology2.25470060
25MP0005645_abnormal_hypothalamus_physiol2.14049430
26MP0008932_abnormal_embryonic_tissue2.02775770
27MP0000537_abnormal_urethra_morphology2.01797988
28MP0000678_abnormal_parathyroid_gland1.99810110
29MP0000013_abnormal_adipose_tissue1.96536862
30MP0003077_abnormal_cell_cycle1.84378371
31MP0003941_abnormal_skin_development1.81098724
32MP0003195_calcinosis1.81031031
33MP0008995_early_reproductive_senescence1.75885966
34MP0005367_renal/urinary_system_phenotyp1.74086793
35MP0000516_abnormal_urinary_system1.74086793
36MP0005508_abnormal_skeleton_morphology1.70328740
37MP0005257_abnormal_intraocular_pressure1.70246039
38MP0001986_abnormal_taste_sensitivity1.70140792
39MP0003283_abnormal_digestive_organ1.69203287
40MP0001243_abnormal_dermal_layer1.67351943
41MP0000733_abnormal_muscle_development1.64727884
42MP0008004_abnormal_stomach_pH1.64281415
43MP0001299_abnormal_eye_distance/1.63083478
44MP0002877_abnormal_melanocyte_morpholog1.62395627
45MP0003385_abnormal_body_wall1.61847118
46MP0009250_abnormal_appendicular_skeleto1.61692982
47MP0004957_abnormal_blastocyst_morpholog1.61400786
48MP0010368_abnormal_lymphatic_system1.61102430
49MP0001542_abnormal_bone_strength1.60123834
50MP0005084_abnormal_gallbladder_morpholo1.58541882
51MP0000566_synostosis1.56421189
52MP0003786_premature_aging1.52411547
53MP0003045_fibrosis1.52235697
54MP0009053_abnormal_anal_canal1.51906850
55MP0002060_abnormal_skin_morphology1.49508910
56MP0000767_abnormal_smooth_muscle1.47233578
57MP0006054_spinal_hemorrhage1.46825749
58MP0000631_abnormal_neuroendocrine_gland1.46284230
59MP0003950_abnormal_plasma_membrane1.45961689
60MP0000350_abnormal_cell_proliferation1.41670741
61MP0003942_abnormal_urinary_system1.39680943
62MP0002168_other_aberrant_phenotype1.36944022
63MP0000751_myopathy1.34608231
64MP0005646_abnormal_pituitary_gland1.30433498
65MP0008058_abnormal_DNA_repair1.28580484
66MP0000750_abnormal_muscle_regeneration1.27326032
67MP0005187_abnormal_penis_morphology1.26271105
68MP0002160_abnormal_reproductive_system1.26202487
69MP0003755_abnormal_palate_morphology1.24663247
70MP0002282_abnormal_trachea_morphology1.24302991
71MP0009672_abnormal_birth_weight1.24281936
72MP0002277_abnormal_respiratory_mucosa1.24130703
73MP0003315_abnormal_perineum_morphology1.22005316
74MP0001485_abnormal_pinna_reflex1.21431858
75MP0002085_abnormal_embryonic_tissue1.18337052
76MP0001286_abnormal_eye_development1.17887907
77MP0000534_abnormal_ureter_morphology1.16474256
78MP0003123_paternal_imprinting1.16107123
79MP0001270_distended_abdomen1.15055185
80MP0002084_abnormal_developmental_patter1.14911359
81MP0000163_abnormal_cartilage_morphology1.13961392
82MP0000747_muscle_weakness1.13739487
83MP0001730_embryonic_growth_arrest1.13485123
84MP0000681_abnormal_thyroid_gland1.11712789
85MP0002896_abnormal_bone_mineralization1.11409364
86MP0002089_abnormal_postnatal_growth/wei1.11214330
87MP0003115_abnormal_respiratory_system1.07765995
88MP0005595_abnormal_vascular_smooth1.07383476
89MP0005390_skeleton_phenotype1.06867146
90MP0002114_abnormal_axial_skeleton1.06462432
91MP0010307_abnormal_tumor_latency1.05981296
92MP0001177_atelectasis1.02855273
93MP0002128_abnormal_blood_circulation1.00730220
94MP0004134_abnormal_chest_morphology1.00094735
95MP0002102_abnormal_ear_morphology0.98925718
96MP0002113_abnormal_skeleton_development0.95637103
97MP0000858_altered_metastatic_potential0.95154352
98MP0003861_abnormal_nervous_system0.91025302
99MP0006138_congestive_heart_failure0.90946961
100MP0001614_abnormal_blood_vessel0.90319707
101MP0002932_abnormal_joint_morphology0.89939485
102MP0003938_abnormal_ear_development0.89426104
103MP0002115_abnormal_skeleton_extremities0.89054581
104MP0002233_abnormal_nose_morphology0.88942246
105MP0003718_maternal_effect0.88008524
106MP0000432_abnormal_head_morphology0.87116078
107MP0005164_abnormal_response_to0.87100816
108MP0001533_abnormal_skeleton_physiology0.86968699
109MP0001881_abnormal_mammary_gland0.85982080
110MP0005388_respiratory_system_phenotype0.85943918
111MP0002133_abnormal_respiratory_system0.85943918
112MP0002127_abnormal_cardiovascular_syste0.85807655
113MP0000428_abnormal_craniofacial_morphol0.85519125
114MP0005379_endocrine/exocrine_gland_phen0.85280099
115MP0002092_abnormal_eye_morphology0.85215473
116MP0001697_abnormal_embryo_size0.85108367
117MP0006276_abnormal_autonomic_nervous0.84893653
118MP0002177_abnormal_outer_ear0.84636049
119MP0003943_abnormal_hepatobiliary_system0.84392139
120MP0000003_abnormal_adipose_tissue0.83778104
121MP0003448_altered_tumor_morphology0.83624055
122MP0008007_abnormal_cellular_replicative0.83031112
123MP0003935_abnormal_craniofacial_develop0.81726514
124MP0002751_abnormal_autonomic_nervous0.81619526
125MP0002234_abnormal_pharynx_morphology0.80503874
126MP0005670_abnormal_white_adipose0.79561502
127MP0005193_abnormal_anterior_eye0.78910977
128MP0001293_anophthalmia0.77342612
129MP0000762_abnormal_tongue_morphology0.76791764
130MP0001175_abnormal_lung_morphology0.75825559
131MP0002933_joint_inflammation0.75750542
132MP0001879_abnormal_lymphatic_vessel0.75563926
133MP0001529_abnormal_vocalization0.75561059
134MP0006292_abnormal_olfactory_placode0.75410401
135MP0002098_abnormal_vibrissa_morphology0.74959588
136MP0005197_abnormal_uvea_morphology0.74262092
137MP0005380_embryogenesis_phenotype0.73938264
138MP0001672_abnormal_embryogenesis/_devel0.73938264
139MP0002080_prenatal_lethality0.73718913
140MP0002697_abnormal_eye_size0.73653053
141MP0000049_abnormal_middle_ear0.73515844
142MP0002111_abnormal_tail_morphology0.71940253
143MP0003937_abnormal_limbs/digits/tail_de0.71722848
144MP0004233_abnormal_muscle_weight0.71283326
145MP0009046_muscle_twitch0.71226105
146MP0002925_abnormal_cardiovascular_devel0.70952335
147MP0002108_abnormal_muscle_morphology0.70193599
148MP0000467_abnormal_esophagus_morphology0.70079972
149MP0004883_abnormal_blood_vessel0.69400986
150MP0002998_abnormal_bone_remodeling0.68949360
151MP0002116_abnormal_craniofacial_bone0.68822782
152MP0004782_abnormal_surfactant_physiolog0.68232343
153MP0001486_abnormal_startle_reflex0.67377338
154MP0004087_abnormal_muscle_fiber0.67109354
155MP0003300_gastrointestinal_ulcer0.66327124
156MP0005330_cardiomyopathy0.66164662
157MP0001145_abnormal_male_reproductive0.66049344
158MP0000313_abnormal_cell_death0.65649741
159MP0004133_heterotaxia0.65148745
160MP0005621_abnormal_cell_physiology0.64365144
161MP0004808_abnormal_hematopoietic_stem0.64315043
162MP0005395_other_phenotype0.63501819
163MP0003795_abnormal_bone_structure0.63435593
164MP0005620_abnormal_muscle_contractility0.63021911
165MP0001340_abnormal_eyelid_morphology0.62248058
166MP0002928_abnormal_bile_duct0.61615016
167MP0002109_abnormal_limb_morphology0.60994723
168MP0004084_abnormal_cardiac_muscle0.60167055
169MP0001915_intracranial_hemorrhage0.59613201

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.84059651
2Protrusio acetabuli (HP:0003179)7.75390522
3Aortic dissection (HP:0002647)5.43929227
4Peritonitis (HP:0002586)5.27515471
5Shallow orbits (HP:0000586)4.94581440
6Abnormal umbilical cord blood vessels (HP:0011403)4.75023236
7Single umbilical artery (HP:0001195)4.75023236
8Abnormality of the fetal cardiovascular system (HP:0010948)4.75023236
9Abnormality of the middle phalanges of the toes (HP:0010183)4.72590268
10Abnormality of the aortic arch (HP:0012303)4.53000657
11Cerebral aneurysm (HP:0004944)4.50793396
12Atrophic scars (HP:0001075)4.48737704
13Septate vagina (HP:0001153)4.47270259
14Aortic aneurysm (HP:0004942)4.46333916
15Soft skin (HP:0000977)4.45489606
16Abnormality of dentin (HP:0010299)4.45004106
17Dilatation of the ascending aorta (HP:0005111)4.44539011
18Abnormality of the phalanges of the hallux (HP:0010057)4.20887996
19Birth length less than 3rd percentile (HP:0003561)4.11510188
20Cervical subluxation (HP:0003308)4.04829066
21Abnormal ventriculo-arterial connection (HP:0011563)4.04180581
22Transposition of the great arteries (HP:0001669)4.04180581
23Abnormal connection of the cardiac segments (HP:0011545)4.04180581
24Abnormality of the distal phalanges of the toes (HP:0010182)3.78134636
25Broad distal phalanx of finger (HP:0009836)3.77220738
26Amblyopia (HP:0000646)3.68708765
27Double outlet right ventricle (HP:0001719)3.64239086
28Congenital malformation of the right heart (HP:0011723)3.64239086
29Blue sclerae (HP:0000592)3.55615074
30Bladder diverticulum (HP:0000015)3.54301817
31Spinal rigidity (HP:0003306)3.50959734
32Fragile skin (HP:0001030)3.49535191
33Homocystinuria (HP:0002156)3.44018910
34Abnormality of homocysteine metabolism (HP:0010919)3.44018910
35Abnormal number of incisors (HP:0011064)3.43930765
36Ankle contracture (HP:0006466)3.39484816
37Hypoplastic left heart (HP:0004383)3.38182676
38Wormian bones (HP:0002645)3.34718723
39Genu recurvatum (HP:0002816)3.29990678
40Neonatal short-limb short stature (HP:0008921)3.29583415
41Abnormality of the umbilical cord (HP:0010881)3.26255505
42Biconcave vertebral bodies (HP:0004586)3.23115399
43Vertebral compression fractures (HP:0002953)3.22568354
44Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21565533
45Vascular tortuosity (HP:0004948)3.14716220
46Wrist flexion contracture (HP:0001239)3.13633978
47Short middle phalanx of the 5th finger (HP:0004220)3.10999525
48Short nail (HP:0001799)3.08969464
49Camptodactyly of toe (HP:0001836)3.06604787
50Infantile muscular hypotonia (HP:0008947)3.03860272
51Increased density of long bones (HP:0006392)3.03793099
52Mitral valve prolapse (HP:0001634)3.01583219
53Bowel diverticulosis (HP:0005222)2.87804732
54Broad metatarsal (HP:0001783)2.83879653
55Scapular winging (HP:0003691)2.83785903
56Abnormality of the calcaneus (HP:0008364)2.75571852
57Preaxial foot polydactyly (HP:0001841)2.74393565
58Aplastic anemia (HP:0001915)2.71910488
59Hyperextensible skin (HP:0000974)2.69410125
60Type II lissencephaly (HP:0007260)2.68436568
61Abnormal delivery (HP:0001787)2.65869686
62Buphthalmos (HP:0000557)2.65573008
63Abnormal number of erythroid precursors (HP:0012131)2.59997829
64Round ear (HP:0100830)2.59457335
65Microvesicular hepatic steatosis (HP:0001414)2.59286013
66Increased connective tissue (HP:0009025)2.57098716
67Pheochromocytoma (HP:0002666)2.55982722
68Cutaneous melanoma (HP:0012056)2.55181936
69Elbow flexion contracture (HP:0002987)2.54890046
70Right ventricular cardiomyopathy (HP:0011663)2.52268231
71Hypoplastic heart (HP:0001961)2.51755355
72Mesomelia (HP:0003027)2.51466951
73Microretrognathia (HP:0000308)2.49088564
74Breast hypoplasia (HP:0003187)2.46829880
75Periauricular skin pits (HP:0100277)2.46678439
76Preauricular pit (HP:0004467)2.46678439
77Gastrointestinal dysmotility (HP:0002579)2.44353082
78Abnormality of the acetabulum (HP:0003170)2.43577495
79Arterial tortuosity (HP:0005116)2.41752437
80Short clavicles (HP:0000894)2.39560394
81Broad face (HP:0000283)2.37981376
82Persistence of primary teeth (HP:0006335)2.37313076
83Diastasis recti (HP:0001540)2.37113766
84Aplasia/Hypoplasia of the clavicles (HP:0006710)2.36796996
85Distal upper limb amyotrophy (HP:0007149)2.36381078
86Upper limb amyotrophy (HP:0009129)2.36381078
87Hydroureter (HP:0000072)2.36087446
88Ectopia lentis (HP:0001083)2.33953148
89Sclerocornea (HP:0000647)2.33847863
90Flexion contracture of toe (HP:0005830)2.33733003
91Joint contractures involving the joints of the feet (HP:0100492)2.33733003
92Peripheral hypomyelination (HP:0007182)2.33612252
93Abnormality of chromosome segregation (HP:0002916)2.33059935
94Abnormality of cells of the erythroid lineage (HP:0012130)2.33046554
95Aneurysm (HP:0002617)2.32306231
96Congenital glaucoma (HP:0001087)2.31869407
97Renal dysplasia (HP:0000110)2.30095147
98Truncus arteriosus (HP:0001660)2.29893579
99Type 1 muscle fiber predominance (HP:0003803)2.29736941
100Abnormality of the parathyroid morphology (HP:0011766)2.28192289
101Mitral regurgitation (HP:0001653)2.28052063
102Radial bowing (HP:0002986)2.26621966
103Shoulder girdle muscle weakness (HP:0003547)2.25652839
104Increased variability in muscle fiber diameter (HP:0003557)2.25591089
105Back pain (HP:0003418)2.25438692
106Neuroendocrine neoplasm (HP:0100634)2.25181442
107Abnormality of the peritoneum (HP:0002585)2.25164263
108Osteolytic defects of the phalanges of the hand (HP:0009771)2.23042938
109Osteolytic defects of the hand bones (HP:0009699)2.23042938
110Overgrowth (HP:0001548)2.22685323
111Knee flexion contracture (HP:0006380)2.20772418
112Spinal cord compression (HP:0002176)2.19630679
113Esophageal atresia (HP:0002032)2.18433846
114Unilateral renal agenesis (HP:0000122)2.18268775
115Ulnar bowing (HP:0003031)2.18182254
116Spinal cord lesions (HP:0100561)2.16038973
117Syringomyelia (HP:0003396)2.16038973
118Abnormality of the 4th metacarpal (HP:0010012)2.15664680
119Difficulty climbing stairs (HP:0003551)2.15574433
120Bowing of the arm (HP:0006488)2.12543234
121Bowed forearm bones (HP:0003956)2.12543234
122Chondrocalcinosis (HP:0000934)2.12282049
123Coronal craniosynostosis (HP:0004440)2.11427774
124Calcaneovalgus deformity (HP:0001848)2.10933981
125Hallux valgus (HP:0001822)2.10140736
126Distal lower limb amyotrophy (HP:0008944)2.09753638
127Midline defect of the nose (HP:0004122)2.08636227
128Germ cell neoplasia (HP:0100728)2.08551953
129Wide anterior fontanel (HP:0000260)2.07783896
130Optic nerve hypoplasia (HP:0000609)2.06782919
131Short 5th finger (HP:0009237)2.06776965
132Rectal fistula (HP:0100590)2.06073490
133Rectovaginal fistula (HP:0000143)2.06073490
134Deviation of the hallux (HP:0010051)2.06065071
135Bifid scrotum (HP:0000048)2.05321809
136Xerostomia (HP:0000217)2.05226260
137Joint laxity (HP:0001388)2.04862164
138Meckel diverticulum (HP:0002245)2.02742711
139Megaloblastic anemia (HP:0001889)2.01100513
140Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.00963787
141Supernumerary spleens (HP:0009799)1.99982965
142Increased mean platelet volume (HP:0011877)1.99757559
143Anencephaly (HP:0002323)1.99712588
144Abnormality of skeletal muscle fiber size (HP:0012084)1.99444037
145Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.98939342
146Broad ribs (HP:0000885)1.98824676
147Gastrointestinal atresia (HP:0002589)1.98652028
148Tibial bowing (HP:0002982)1.98149092
149Nonimmune hydrops fetalis (HP:0001790)1.97422172
150Abnormality of Sharpey fibers (HP:0100685)1.94853728
151Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.92287117
152Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.89345941
153Thin bony cortex (HP:0002753)1.89281015
154Abnormality of the ileum (HP:0001549)1.89043860
155Coxa vara (HP:0002812)1.87639966
156Duplication of thumb phalanx (HP:0009942)1.87146683
157High anterior hairline (HP:0009890)1.86789766
158Deformed tarsal bones (HP:0008119)1.85799345
159Aplasia/Hypoplasia of the patella (HP:0006498)1.85687728
160Joint stiffness (HP:0001387)1.85416346
161Tarsal synostosis (HP:0008368)1.85283416
162Absent radius (HP:0003974)1.84460419
163Abnormality of the distal phalanx of the thumb (HP:0009617)1.83638588
164Slender long bone (HP:0003100)1.83224179
165Muscle fiber splitting (HP:0003555)1.82809752
166Fibular aplasia (HP:0002990)1.82332208
167Abnormality of sulfur amino acid metabolism (HP:0004339)1.80931172
168Hand muscle atrophy (HP:0009130)1.79003137
169Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.78492713
170Rectal prolapse (HP:0002035)1.77101416
171Retinal dysplasia (HP:0007973)1.77082283
172Occipital encephalocele (HP:0002085)1.77009988
173Bradycardia (HP:0001662)1.76918080
174Bell-shaped thorax (HP:0001591)1.76870244
175Triphalangeal thumb (HP:0001199)1.76820813
176Vaginal fistula (HP:0004320)1.76283310
177Venous abnormality (HP:0002624)1.75842295
178Aplasia involving forearm bones (HP:0009822)1.75595366
179Absent forearm bone (HP:0003953)1.75595366
180Selective tooth agenesis (HP:0001592)1.75229624
181Partial duplication of the phalanx of hand (HP:0009999)1.74599235
182Absent phalangeal crease (HP:0006109)1.74229766
183Osteopenia (HP:0000938)1.72498909
184Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.72380418
185Abnormal platelet volume (HP:0011876)1.71644939
186Abnormality of the anterior chamber (HP:0000593)1.71055834
187Patellar aplasia (HP:0006443)1.70853240
188Intestinal fistula (HP:0100819)1.69394826
189Spondylolisthesis (HP:0003302)1.69054470
190Facial cleft (HP:0002006)1.68432932
191Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.68085243
192Pendular nystagmus (HP:0012043)1.65766459
193Bicornuate uterus (HP:0000813)1.65443872
194Non-midline cleft lip (HP:0100335)1.64211523
195Preaxial hand polydactyly (HP:0001177)1.63917692

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.96274827
2TESK24.28275542
3LIMK14.17235683
4CDK193.75646449
5TTN3.71617349
6LATS23.64659797
7STK163.50191259
8CDC73.39797924
9CDK123.26783187
10DDR23.16839470
11PAK22.70965505
12MYLK2.66683679
13FRK2.62954523
14PIK3CG2.54237316
15LATS12.52714394
16TRPM72.52074571
17PIK3CA2.42635785
18PAK32.42509590
19TEC2.38413692
20ERBB32.33332258
21TRIB32.18931977
22SRPK12.12437899
23CSNK1G32.08667065
24GRK72.02767453
25PTK2B2.01590551
26PDGFRA1.96085944
27CSNK1A1L1.95315138
28VRK21.94976474
29PTK21.83921344
30PIM21.78231879
31OXSR11.75263937
32SMG11.69056983
33LRRK21.68084868
34CSNK1G11.66726621
35PNCK1.64483183
36PINK11.63149162
37CHEK21.60324488
38TTK1.59814886
39MKNK21.52766282
40EPHA21.52605607
41CSNK1G21.41599885
42EPHB21.40673580
43TSSK61.40511097
44ATR1.35780631
45EIF2AK11.31415288
46STK38L1.30176045
47STK101.29331039
48RPS6KA41.28869418
49TRIM281.27256433
50DYRK21.26362739
51DMPK1.25275990
52BMX1.23880098
53CDC42BPA1.23294950
54ROCK11.22505351
55DAPK31.22470499
56ZAK1.21294516
57RIPK11.17705905
58FER1.15857861
59MAPKAPK31.14726719
60PKN21.13794965
61MAP3K121.13761469
62ILK1.09468863
63STK41.09463019
64MAPK151.08291676
65BRD41.07276137
66BRSK21.04643446
67NME21.04022113
68CDK91.03222848
69ERN11.03173172
70ITK1.01878114
71KDR1.00260999
72FGFR10.98975438
73SIK20.96959803
74BCR0.96215658
75PAK40.93806300
76STK30.93199260
77CDK70.92671297
78MAP3K50.92533421
79PAK10.89369744
80MOS0.87551552
81PLK10.87298250
82PTK60.86628304
83MAP3K80.81267336
84EPHA40.80501474
85NEK20.80304009
86CDK80.80297744
87MAP2K10.79073712
88DYRK1A0.74587629
89PLK20.74504303
90CSNK1E0.72684497
91CDK40.72460894
92BUB10.69920081
93STK110.67494053
94MAPKAPK50.67463089
95INSR0.67209301
96TAF10.66833842
97MINK10.66649534
98SCYL20.66566126
99MET0.66305568
100NUAK10.65516241
101ALK0.64485984
102PRKD10.63870436
103TLK10.63858569
104ATM0.63663868
105GRK10.61619348
106FGFR20.60198373
107RPS6KA50.59187641
108NME10.58257260
109ROCK20.57719263
110VRK10.56989929
111MKNK10.56719226
112WNK30.56616696
113ABL20.55858686
114MTOR0.55762440
115MAP3K130.55751552
116CHEK10.55625487
117PDGFRB0.55266642
118CAMK1G0.53007777
119MAP2K40.52923151
120NTRK10.52409544
121CDK140.52270185
122NEK90.51813045
123PLK40.51730791
124RPS6KB20.51500542
125PRKG20.51354636
126CDK20.49937283
127CSNK2A10.48791490
128NTRK30.46793010
129CDK150.46430500
130MAP3K110.46113367
131ERBB40.45152701
132SRC0.45152395
133BRSK10.44280852
134CAMKK20.42717291
135EIF2AK30.42704442
136CDK180.42452516
137CDK10.42287778
138TAOK20.41578244
139ADRBK20.39210858
140CDK11A0.39085326
141EEF2K0.39018674
142CDK30.38449938
143CAMKK10.36829412
144TGFBR20.36349792
145SIK10.36054540
146NEK10.36051534
147PLK30.35788444
148RET0.34772551
149AURKA0.34341317
150MAP3K30.33135083
151PRKD20.31960678
152MAP3K100.30918470
153EGFR0.30833841
154MAP2K30.30695456
155IGF1R0.30626158
156STK380.30607585
157MAPKAPK20.26916469
158PAK60.25630353
159ABL10.23927820
160FYN0.23638682
161AURKB0.22094107
162PRKCI0.19269311
163RAF10.17967227
164TAOK10.17241936
165PRKCH0.17037233

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.89521466
2Sulfur relay system_Homo sapiens_hsa041223.70911877
3Bacterial invasion of epithelial cells_Homo sapiens_hsa051003.28086525
4Focal adhesion_Homo sapiens_hsa045103.27871602
5DNA replication_Homo sapiens_hsa030303.25093212
6Bladder cancer_Homo sapiens_hsa052193.03088149
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.98661459
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.88909821
9Phototransduction_Homo sapiens_hsa047442.86257241
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.85208993
11Shigellosis_Homo sapiens_hsa051312.83701340
12Dilated cardiomyopathy_Homo sapiens_hsa054142.77827922
13Proteoglycans in cancer_Homo sapiens_hsa052052.61151160
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.60958760
15p53 signaling pathway_Homo sapiens_hsa041152.60636613
16Oxidative phosphorylation_Homo sapiens_hsa001902.56588736
17Mismatch repair_Homo sapiens_hsa034302.54878312
18Spliceosome_Homo sapiens_hsa030402.50364357
19Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.45190584
20Adherens junction_Homo sapiens_hsa045202.42258774
21TGF-beta signaling pathway_Homo sapiens_hsa043502.40305116
22Parkinsons disease_Homo sapiens_hsa050122.34575430
23Ribosome_Homo sapiens_hsa030102.31885143
24Hippo signaling pathway_Homo sapiens_hsa043902.31693428
25Folate biosynthesis_Homo sapiens_hsa007902.28323485
26Regulation of actin cytoskeleton_Homo sapiens_hsa048102.27020635
27Malaria_Homo sapiens_hsa051442.21157718
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17607242
29Amoebiasis_Homo sapiens_hsa051462.15194343
30MicroRNAs in cancer_Homo sapiens_hsa052062.08305241
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07099841
32Huntingtons disease_Homo sapiens_hsa050162.04283086
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.04103617
34Cysteine and methionine metabolism_Homo sapiens_hsa002702.01129024
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.96570198
36RNA polymerase_Homo sapiens_hsa030201.89188673
37Small cell lung cancer_Homo sapiens_hsa052221.87507478
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87275382
39Homologous recombination_Homo sapiens_hsa034401.82780875
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.82267142
41Pyrimidine metabolism_Homo sapiens_hsa002401.65805680
42RNA transport_Homo sapiens_hsa030131.60970726
43Phagosome_Homo sapiens_hsa041451.59503077
44Basal transcription factors_Homo sapiens_hsa030221.55398546
45Vitamin B6 metabolism_Homo sapiens_hsa007501.46352542
46Salmonella infection_Homo sapiens_hsa051321.44353246
47Tight junction_Homo sapiens_hsa045301.42748191
48Chronic myeloid leukemia_Homo sapiens_hsa052201.41244663
49Fanconi anemia pathway_Homo sapiens_hsa034601.40224607
50Alzheimers disease_Homo sapiens_hsa050101.38917535
51Base excision repair_Homo sapiens_hsa034101.38818115
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.37100963
53PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36298899
54Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.34633161
55Non-homologous end-joining_Homo sapiens_hsa034501.31761574
56Rap1 signaling pathway_Homo sapiens_hsa040151.24650230
57Melanoma_Homo sapiens_hsa052181.23201961
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20597384
59Platelet activation_Homo sapiens_hsa046111.18195589
60Taste transduction_Homo sapiens_hsa047421.15381401
61Axon guidance_Homo sapiens_hsa043601.14580071
62Viral myocarditis_Homo sapiens_hsa054161.13498387
63Nucleotide excision repair_Homo sapiens_hsa034201.12242677
64Circadian rhythm_Homo sapiens_hsa047101.11234685
65mRNA surveillance pathway_Homo sapiens_hsa030151.09842651
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.06848378
67Pancreatic cancer_Homo sapiens_hsa052121.05329912
68Protein digestion and absorption_Homo sapiens_hsa049741.04384205
69Vibrio cholerae infection_Homo sapiens_hsa051101.04299363
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00486078
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98837733
72Pertussis_Homo sapiens_hsa051330.97285192
73Leishmaniasis_Homo sapiens_hsa051400.95674103
74Viral carcinogenesis_Homo sapiens_hsa052030.95638606
75Biosynthesis of amino acids_Homo sapiens_hsa012300.92942585
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92715651
77Arginine and proline metabolism_Homo sapiens_hsa003300.92285730
78Sulfur metabolism_Homo sapiens_hsa009200.92127025
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.90753998
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.87736318
81TNF signaling pathway_Homo sapiens_hsa046680.87064861
82Purine metabolism_Homo sapiens_hsa002300.85472235
83Pathways in cancer_Homo sapiens_hsa052000.85204948
84Gap junction_Homo sapiens_hsa045400.85191419
85Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85103852
86Colorectal cancer_Homo sapiens_hsa052100.84907746
87Basal cell carcinoma_Homo sapiens_hsa052170.84692740
88Apoptosis_Homo sapiens_hsa042100.84400453
89Pyruvate metabolism_Homo sapiens_hsa006200.81434360
90Glioma_Homo sapiens_hsa052140.80152317
91VEGF signaling pathway_Homo sapiens_hsa043700.79952455
92Cardiac muscle contraction_Homo sapiens_hsa042600.79875365
93Pancreatic secretion_Homo sapiens_hsa049720.78925293
94Fat digestion and absorption_Homo sapiens_hsa049750.78674156
95HTLV-I infection_Homo sapiens_hsa051660.77845234
96Endocytosis_Homo sapiens_hsa041440.76830782
97HIF-1 signaling pathway_Homo sapiens_hsa040660.73483039
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73218877
99RNA degradation_Homo sapiens_hsa030180.72062210
100Phenylalanine metabolism_Homo sapiens_hsa003600.70614643
101Toxoplasmosis_Homo sapiens_hsa051450.64010361
102Cell cycle_Homo sapiens_hsa041100.63898507
103Renal cell carcinoma_Homo sapiens_hsa052110.63595454
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.62570754
105Neurotrophin signaling pathway_Homo sapiens_hsa047220.60487191
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.60083656
107Hedgehog signaling pathway_Homo sapiens_hsa043400.58261925
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57474616
109Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57259662
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55738416
111GnRH signaling pathway_Homo sapiens_hsa049120.55634474
112Maturity onset diabetes of the young_Homo sapiens_hsa049500.54976073
113Complement and coagulation cascades_Homo sapiens_hsa046100.52753675
114Vitamin digestion and absorption_Homo sapiens_hsa049770.52532001
115Protein export_Homo sapiens_hsa030600.52049753
116Hepatitis B_Homo sapiens_hsa051610.51932637
117Prostate cancer_Homo sapiens_hsa052150.51098501
118Rheumatoid arthritis_Homo sapiens_hsa053230.50212498
119ErbB signaling pathway_Homo sapiens_hsa040120.49745392
120Ras signaling pathway_Homo sapiens_hsa040140.49558654
121Ovarian steroidogenesis_Homo sapiens_hsa049130.48594565
122Notch signaling pathway_Homo sapiens_hsa043300.47146904
123Wnt signaling pathway_Homo sapiens_hsa043100.45497802
124Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43732860
125Metabolic pathways_Homo sapiens_hsa011000.43282302
126MAPK signaling pathway_Homo sapiens_hsa040100.43116240
127Renin-angiotensin system_Homo sapiens_hsa046140.42438016
128Chemical carcinogenesis_Homo sapiens_hsa052040.42383883
129Oxytocin signaling pathway_Homo sapiens_hsa049210.41269645
130Melanogenesis_Homo sapiens_hsa049160.40147147
131Selenocompound metabolism_Homo sapiens_hsa004500.39990311
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.39832485
133FoxO signaling pathway_Homo sapiens_hsa040680.39261861
134Prion diseases_Homo sapiens_hsa050200.39209860
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38195947
136Oocyte meiosis_Homo sapiens_hsa041140.38094474
137Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37283360
138Carbon metabolism_Homo sapiens_hsa012000.36612650
139Lysine degradation_Homo sapiens_hsa003100.36426139
140Caffeine metabolism_Homo sapiens_hsa002320.36130639
141Thyroid cancer_Homo sapiens_hsa052160.36030998
142N-Glycan biosynthesis_Homo sapiens_hsa005100.35595478
143Thyroid hormone synthesis_Homo sapiens_hsa049180.33659511
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31137945
145Glycerolipid metabolism_Homo sapiens_hsa005610.30240163
146Estrogen signaling pathway_Homo sapiens_hsa049150.29399436
147Proteasome_Homo sapiens_hsa030500.28613740
148Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28601149
149Sphingolipid signaling pathway_Homo sapiens_hsa040710.26405135
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24914365
151Tuberculosis_Homo sapiens_hsa051520.24755669
152Glutathione metabolism_Homo sapiens_hsa004800.24604036
153Systemic lupus erythematosus_Homo sapiens_hsa053220.23796228
154Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22376896
155Herpes simplex infection_Homo sapiens_hsa051680.21162005
156Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20663708
157Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.20649720
158Endometrial cancer_Homo sapiens_hsa052130.20594650
159One carbon pool by folate_Homo sapiens_hsa006700.19380500
160Arachidonic acid metabolism_Homo sapiens_hsa005900.18809359
161Cocaine addiction_Homo sapiens_hsa050300.18161134
162Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17909857
163Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17605620
164alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15826492
165Linoleic acid metabolism_Homo sapiens_hsa005910.15019069
166Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.14855379
167mTOR signaling pathway_Homo sapiens_hsa041500.14616600
168Alcoholism_Homo sapiens_hsa050340.13984015
169Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.13803924
170Serotonergic synapse_Homo sapiens_hsa047260.12747904
171Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11326756

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