FAM151B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prenylation (GO:0097354)6.20022957
2protein prenylation (GO:0018342)6.20022957
3fucose catabolic process (GO:0019317)5.14287991
4L-fucose metabolic process (GO:0042354)5.14287991
5L-fucose catabolic process (GO:0042355)5.14287991
6regulation of triglyceride catabolic process (GO:0010896)5.07629457
7L-phenylalanine catabolic process (GO:0006559)5.00366550
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.00366550
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.67812218
10alpha-linolenic acid metabolic process (GO:0036109)4.66441927
11L-phenylalanine metabolic process (GO:0006558)4.62086002
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.62086002
13aromatic amino acid family catabolic process (GO:0009074)4.24579921
14preassembly of GPI anchor in ER membrane (GO:0016254)4.11530549
15triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.06934506
16indolalkylamine metabolic process (GO:0006586)4.06913793
17positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.01589498
18positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.01589498
19positive regulation of mitotic sister chromatid separation (GO:1901970)4.01589498
20cell wall macromolecule metabolic process (GO:0044036)3.94719163
21cell wall macromolecule catabolic process (GO:0016998)3.94719163
22urea cycle (GO:0000050)3.91953005
23urea metabolic process (GO:0019627)3.91953005
24behavioral response to nicotine (GO:0035095)3.89689061
25bile acid biosynthetic process (GO:0006699)3.72571103
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.70960909
27detection of light stimulus involved in visual perception (GO:0050908)3.63453789
28detection of light stimulus involved in sensory perception (GO:0050962)3.63453789
29complement activation, alternative pathway (GO:0006957)3.63368202
30negative regulation of fibrinolysis (GO:0051918)3.61535183
31detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.58784769
32nitrogen cycle metabolic process (GO:0071941)3.53892476
33indole-containing compound catabolic process (GO:0042436)3.52695910
34indolalkylamine catabolic process (GO:0046218)3.52695910
35tryptophan catabolic process (GO:0006569)3.52695910
36kynurenine metabolic process (GO:0070189)3.52294320
37protein carboxylation (GO:0018214)3.48128416
38peptidyl-glutamic acid carboxylation (GO:0017187)3.48128416
39retinal cone cell development (GO:0046549)3.46642198
40neural tube formation (GO:0001841)3.44504919
41glyoxylate metabolic process (GO:0046487)3.42609009
42cysteine metabolic process (GO:0006534)3.41649852
43bile acid metabolic process (GO:0008206)3.33701995
44lysine catabolic process (GO:0006554)3.32779634
45lysine metabolic process (GO:0006553)3.32779634
46epithelial cilium movement (GO:0003351)3.31033022
47regulation of fibrinolysis (GO:0051917)3.30453329
48cellular extravasation (GO:0045123)3.29272506
49negative regulation of mast cell activation (GO:0033004)3.26421562
50plasma lipoprotein particle clearance (GO:0034381)3.25861394
51regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.25665520
52photoreceptor cell maintenance (GO:0045494)3.23382054
53piRNA metabolic process (GO:0034587)3.20540585
54regulation of protein activation cascade (GO:2000257)3.18636494
55neuron remodeling (GO:0016322)3.18161131
56response to pheromone (GO:0019236)3.17965941
57GPI anchor metabolic process (GO:0006505)3.16713023
58negative regulation of sterol transport (GO:0032372)3.14797461
59negative regulation of cholesterol transport (GO:0032375)3.14797461
60cilium morphogenesis (GO:0060271)3.14054940
61behavioral response to ethanol (GO:0048149)3.13749211
62pyrimidine nucleobase catabolic process (GO:0006208)3.13583665
63seminiferous tubule development (GO:0072520)3.12737028
64axoneme assembly (GO:0035082)3.12406993
65high-density lipoprotein particle remodeling (GO:0034375)3.10345562
66tryptophan metabolic process (GO:0006568)3.08319116
67coenzyme catabolic process (GO:0009109)3.07818457
68fusion of sperm to egg plasma membrane (GO:0007342)3.06324272
69indole-containing compound metabolic process (GO:0042430)3.02036439
70mast cell degranulation (GO:0043303)3.01828174
71mast cell activation involved in immune response (GO:0002279)3.01828174
72C-terminal protein lipidation (GO:0006501)3.00429110
73glutamate metabolic process (GO:0006536)2.99750283
74triglyceride homeostasis (GO:0070328)2.98947420
75acylglycerol homeostasis (GO:0055090)2.98947420
76eosinophil chemotaxis (GO:0048245)2.98721879
77cornea development in camera-type eye (GO:0061303)2.98309795
78platelet dense granule organization (GO:0060155)2.97620406
79regulation of complement activation (GO:0030449)2.97310673
80very long-chain fatty acid metabolic process (GO:0000038)2.96626347
81aspartate family amino acid catabolic process (GO:0009068)2.95760824
82protein K11-linked deubiquitination (GO:0035871)2.94257701
83regulation of cilium movement (GO:0003352)2.92964355
84acrosome assembly (GO:0001675)2.91479082
85sulfur amino acid catabolic process (GO:0000098)2.90878653
86nonmotile primary cilium assembly (GO:0035058)2.90821463
87primary alcohol catabolic process (GO:0034310)2.89153502
88alpha-amino acid catabolic process (GO:1901606)2.87719659
89cilium movement (GO:0003341)2.86218641
90cilium or flagellum-dependent cell motility (GO:0001539)2.86030874
91regulation of triglyceride metabolic process (GO:0090207)2.85879364
92amine catabolic process (GO:0009310)2.85787674
93cellular biogenic amine catabolic process (GO:0042402)2.85787674
94positive regulation of lipid catabolic process (GO:0050996)2.84407112
95regulation of cholesterol esterification (GO:0010872)2.84188283
96replication fork processing (GO:0031297)2.83878695
97adaptation of signaling pathway (GO:0023058)2.83517614
98dicarboxylic acid biosynthetic process (GO:0043650)2.82347748
99protein-lipid complex remodeling (GO:0034368)2.82046227
100macromolecular complex remodeling (GO:0034367)2.82046227
101plasma lipoprotein particle remodeling (GO:0034369)2.82046227
102C-terminal protein amino acid modification (GO:0018410)2.81786865
103negative regulation of Ras GTPase activity (GO:0034261)2.81781098
104amyloid precursor protein catabolic process (GO:0042987)2.81769678
105recombinational repair (GO:0000725)2.81384765
106double-strand break repair via homologous recombination (GO:0000724)2.80718954
107homocysteine metabolic process (GO:0050667)2.80570501
108linoleic acid metabolic process (GO:0043651)2.80516884
109regulation of cholesterol homeostasis (GO:2000188)2.80396094
110activated T cell proliferation (GO:0050798)2.80311529
111cellular modified amino acid catabolic process (GO:0042219)2.78109192
112water-soluble vitamin biosynthetic process (GO:0042364)2.77400175
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.77310113
114ethanol metabolic process (GO:0006067)2.77149741
115protein polyglutamylation (GO:0018095)2.76536807
116dopamine transport (GO:0015872)2.76420455
117DNA double-strand break processing (GO:0000729)2.76376075
118intraciliary transport (GO:0042073)2.75958865
119aldehyde catabolic process (GO:0046185)2.75936671
120gamma-aminobutyric acid transport (GO:0015812)2.75211483
121cofactor catabolic process (GO:0051187)2.74856985
122short-chain fatty acid metabolic process (GO:0046459)2.74726914
123photoreceptor cell development (GO:0042461)2.73672427
124negative regulation of cytosolic calcium ion concentration (GO:0051481)2.73130604
125cilium organization (GO:0044782)2.71408328
126amino-acid betaine metabolic process (GO:0006577)2.70260531
127proteasome assembly (GO:0043248)2.69930167
128protein import into peroxisome matrix (GO:0016558)2.69683426
129negative regulation of T cell receptor signaling pathway (GO:0050860)2.69531210
130serine family amino acid catabolic process (GO:0009071)2.69470193
131eosinophil migration (GO:0072677)2.69358052
132DNA demethylation (GO:0080111)2.68966070
133tachykinin receptor signaling pathway (GO:0007217)2.68537283
134cellular amino acid catabolic process (GO:0009063)2.68270878
135fatty acid oxidation (GO:0019395)2.67769623
136aromatic amino acid family metabolic process (GO:0009072)2.67731494
137reverse cholesterol transport (GO:0043691)2.67542532
138lipid oxidation (GO:0034440)2.67089821
139nucleobase catabolic process (GO:0046113)2.66762399
140protein localization to cilium (GO:0061512)2.66501931
141positive regulation of calcium ion import (GO:0090280)2.65501571
142phospholipid efflux (GO:0033700)2.64963215
143GPI anchor biosynthetic process (GO:0006506)2.64903090
144fatty acid beta-oxidation (GO:0006635)2.64136437
145ketone body metabolic process (GO:1902224)2.63797257
146cilium assembly (GO:0042384)2.63520085
147DNA integration (GO:0015074)2.63075732
148auditory receptor cell stereocilium organization (GO:0060088)2.62330549
149DNA deamination (GO:0045006)2.61421956
150cellular ketone body metabolic process (GO:0046950)2.61031979
151cholesterol efflux (GO:0033344)2.61011987
152reflex (GO:0060004)2.60679005
153response to mercury ion (GO:0046689)2.60586361
154multicellular organism reproduction (GO:0032504)2.60168067
155glycolipid biosynthetic process (GO:0009247)2.60130089
156ethanol oxidation (GO:0006069)2.59835944
157response to methylmercury (GO:0051597)2.59313963
158regulation of lipid catabolic process (GO:0050994)2.58887357
159bile acid and bile salt transport (GO:0015721)2.58739820
160drug catabolic process (GO:0042737)2.58616438
161negative regulation of lipid catabolic process (GO:0050995)2.58437366
162oxidative demethylation (GO:0070989)2.57598184
163negative regulation of lipase activity (GO:0060192)2.54686111
164cellular glucuronidation (GO:0052695)2.54674538
165inner ear receptor stereocilium organization (GO:0060122)2.53244542
166fatty acid catabolic process (GO:0009062)2.52752644
167DNA methylation involved in gamete generation (GO:0043046)2.52663165
168fibrinolysis (GO:0042730)2.52360632
169cholesterol homeostasis (GO:0042632)2.51270247
170regulation of meiosis I (GO:0060631)2.51044056
171pantothenate metabolic process (GO:0015939)2.50726676
172negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.50720791
173positive regulation of fatty acid beta-oxidation (GO:0032000)2.50666621
174glycosphingolipid biosynthetic process (GO:0006688)2.50385637
175detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.49420671
176detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.49263693
177sterol homeostasis (GO:0055092)2.48539248
178eye photoreceptor cell development (GO:0042462)2.48411604
179drug transmembrane transport (GO:0006855)2.48386651
180protein-lipid complex assembly (GO:0065005)2.48283414
181low-density lipoprotein particle remodeling (GO:0034374)2.47685505
182complement activation, classical pathway (GO:0006958)2.45282858
183presynaptic membrane assembly (GO:0097105)2.45000507
184opsonization (GO:0008228)2.44148825
185growth hormone receptor signaling pathway (GO:0060396)2.43608564
186proline transport (GO:0015824)2.43495639
187regulation of rhodopsin mediated signaling pathway (GO:0022400)2.43302985
188respiratory chain complex IV assembly (GO:0008535)2.42912814
189serotonin metabolic process (GO:0042428)2.41585073
190rhodopsin mediated signaling pathway (GO:0016056)2.41322991
191fucosylation (GO:0036065)2.40449436
192establishment of protein localization to Golgi (GO:0072600)2.40130890
193vesicle fusion (GO:0006906)2.38065525

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.90265778
2VDR_22108803_ChIP-Seq_LS180_Human3.71502976
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.65759207
4ZNF274_21170338_ChIP-Seq_K562_Hela3.44540120
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.28351403
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.12492958
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.86778826
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.73455001
9POU3F2_20337985_ChIP-ChIP_501MEL_Human2.71886282
10IGF1R_20145208_ChIP-Seq_DFB_Human2.61381100
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54186577
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.42799046
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.36750425
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33124980
15FUS_26573619_Chip-Seq_HEK293_Human2.26023359
16CTBP2_25329375_ChIP-Seq_LNCAP_Human2.15848075
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.01134107
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.00766645
19EWS_26573619_Chip-Seq_HEK293_Human1.98608081
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97895565
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.94754628
22ER_23166858_ChIP-Seq_MCF-7_Human1.90715436
23CTBP1_25329375_ChIP-Seq_LNCAP_Human1.90563052
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87084889
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.82096886
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.81131102
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.74532790
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71190184
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68466263
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68193891
31SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66529252
32SMAD4_21799915_ChIP-Seq_A2780_Human1.65339691
33STAT3_23295773_ChIP-Seq_U87_Human1.62285308
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60218702
35NR3C1_21868756_ChIP-Seq_MCF10A_Human1.59594975
36CBP_20019798_ChIP-Seq_JUKART_Human1.58824690
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.58824690
38POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57704301
39TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57704301
40GATA1_22025678_ChIP-Seq_K562_Human1.57383850
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.55946569
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.55327986
43PCGF2_27294783_Chip-Seq_NPCs_Mouse1.54846700
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.54774247
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53654124
46IRF1_19129219_ChIP-ChIP_H3396_Human1.49820960
47TCF4_23295773_ChIP-Seq_U87_Human1.48769913
48EZH2_27294783_Chip-Seq_NPCs_Mouse1.46990483
49MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46599708
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.46305852
51AR_25329375_ChIP-Seq_VCAP_Human1.46194911
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.45881639
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.43752480
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42750080
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.40650365
56TCF4_22108803_ChIP-Seq_LS180_Human1.40434108
57TP53_22573176_ChIP-Seq_HFKS_Human1.39560641
58IRF8_21731497_ChIP-ChIP_J774_Mouse1.39197295
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.36687120
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.35688952
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34935822
62RUNX_20019798_ChIP-Seq_JUKART_Human1.34267454
63EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33617098
64NANOG_18555785_Chip-Seq_ESCs_Mouse1.32165838
65KLF5_20875108_ChIP-Seq_MESCs_Mouse1.31987854
66NANOG_19829295_ChIP-Seq_ESCs_Human1.30493062
67SOX2_19829295_ChIP-Seq_ESCs_Human1.30493062
68CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28591818
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.28230640
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27408389
71FLI1_21867929_ChIP-Seq_TH2_Mouse1.27164198
72KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.24505502
73CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24474462
74RUNX2_22187159_ChIP-Seq_PCA_Human1.24266890
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24185469
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.24031981
77SCL_19346495_ChIP-Seq_HPC-7_Human1.22911419
78ELK1_19687146_ChIP-ChIP_HELA_Human1.21904412
79VDR_24787735_ChIP-Seq_THP-1_Human1.21101753
80P53_22387025_ChIP-Seq_ESCs_Mouse1.20424624
81SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.17621307
82E2F1_18555785_Chip-Seq_ESCs_Mouse1.17417445
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16648168
84FOXO3_23340844_ChIP-Seq_DLD1_Human1.16067451
85GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.15064144
86FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14271993
87FOXA1_25329375_ChIP-Seq_VCAP_Human1.12834884
88FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12834884
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.12800610
90SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12123758
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.11204591
92CDX2_22108803_ChIP-Seq_LS180_Human1.10894468
93FOXA2_19822575_ChIP-Seq_HepG2_Human1.10556911
94PRDM14_20953172_ChIP-Seq_ESCs_Human1.09894063
95GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08430155
96TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.08288932
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07619186
98P300_18555785_Chip-Seq_ESCs_Mouse1.06351908
99SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.06046171
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.05311296
101MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04922032
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.04757903
103SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04619921
104EGR1_19032775_ChIP-ChIP_M12_Human1.04195294
105GATA2_21666600_ChIP-Seq_HMVEC_Human1.03463891
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03134867
107SMAD4_21741376_ChIP-Seq_EPCs_Human1.02992373
108TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02947734
109TAF15_26573619_Chip-Seq_HEK293_Human1.02879669
110OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01972660
111RNF2_27304074_Chip-Seq_NSC_Mouse1.01926932
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01292959
113AR_21572438_ChIP-Seq_LNCaP_Human1.00856630
114SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99756359
115NCOR_22424771_ChIP-Seq_293T_Human0.99386835
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98288186
117AR_20517297_ChIP-Seq_VCAP_Human0.98200123
118TAL1_26923725_Chip-Seq_HPCs_Mouse0.97001923
119SOX2_21211035_ChIP-Seq_LN229_Gbm0.96990966
120* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96886772
121FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96389753
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96268535
123STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.95135254
124KDM2B_26808549_Chip-Seq_REH_Human0.93754725
125SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.92930509
126GATA2_19941826_ChIP-Seq_K562_Human0.92360286
127ESR1_20079471_ChIP-ChIP_T-47D_Human0.91990931
128TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91309059
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89889972
130NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89169770
131SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89052229
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88803676
133DROSHA_22980978_ChIP-Seq_HELA_Human0.88608809
134SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88230947
135CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87778452
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87660779
137GATA1_19941826_ChIP-Seq_K562_Human0.87496560
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87469542
139BCAT_22108803_ChIP-Seq_LS180_Human0.87153768
140RXR_22108803_ChIP-Seq_LS180_Human0.86265467
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85186052
142ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84935671
143PIAS1_25552417_ChIP-Seq_VCAP_Human0.84541313
144GBX2_23144817_ChIP-Seq_PC3_Human0.82961347
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.82420245
146ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82170496
147EZH2_27294783_Chip-Seq_ESCs_Mouse0.81807249
148NRF2_20460467_ChIP-Seq_MEFs_Mouse0.81794973
149NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.81794973
150NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81243138
151TRIM28_21343339_ChIP-Seq_HEK293_Human0.77453132
152REST_21632747_ChIP-Seq_MESCs_Mouse0.77012786
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.76228440
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.75932015
155TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75837511
156GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75491745
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75204238
158FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.75055118
159EZH2_18974828_ChIP-Seq_MESCs_Mouse0.74294907
160RNF2_18974828_ChIP-Seq_MESCs_Mouse0.74294907
161SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74017249
162PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73925882
163PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.73670601
164WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73168854
165CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.72545865
166SOX2_27498859_Chip-Seq_STOMACH_Mouse0.72391472
167EZH2_22144423_ChIP-Seq_EOC_Human0.71852589
168UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.71769556
169TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71710265
170P300_19829295_ChIP-Seq_ESCs_Human0.71584612
171STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.71432639
172SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.70337694
173RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.69944577
174E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.69712502
175RARB_27405468_Chip-Seq_BRAIN_Mouse0.69487571
176* ARNT_22903824_ChIP-Seq_MCF-7_Human0.69317159
177IKZF1_21737484_ChIP-ChIP_HCT116_Human0.69115790
178TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69078178
179VDR_24763502_ChIP-Seq_THP-1_Human0.69065778
180TP53_16413492_ChIP-PET_HCT116_Human0.67994290
181SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.67649397
182LXR_22292898_ChIP-Seq_THP-1_Human0.66747964

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.29326440
2MP0005360_urolithiasis5.22360372
3MP0005085_abnormal_gallbladder_physiolo4.38879000
4MP0005365_abnormal_bile_salt4.21090677
5MP0000569_abnormal_digit_pigmentation3.57988595
6MP0008875_abnormal_xenobiotic_pharmacok3.48300774
7MP0002102_abnormal_ear_morphology3.21305631
8MP0008877_abnormal_DNA_methylation2.86993173
9MP0010329_abnormal_lipoprotein_level2.83549336
10MP0005551_abnormal_eye_electrophysiolog2.80737937
11MP0009840_abnormal_foam_cell2.50522570
12MP0003252_abnormal_bile_duct2.49408883
13MP0000372_irregular_coat_pigmentation2.45015403
14MP0005410_abnormal_fertilization2.36595759
15MP0005646_abnormal_pituitary_gland2.30338226
16MP0000604_amyloidosis2.27795955
17MP0005083_abnormal_biliary_tract2.27016185
18MP0003303_peritoneal_inflammation2.25838061
19MP0005645_abnormal_hypothalamus_physiol2.23945494
20MP0003690_abnormal_glial_cell2.23274890
21MP0003191_abnormal_cellular_cholesterol2.14849059
22MP0005332_abnormal_amino_acid2.12244264
23MP0005253_abnormal_eye_physiology2.07744963
24MP0001968_abnormal_touch/_nociception2.06359952
25MP0003329_amyloid_beta_deposits2.05792590
26MP0000427_abnormal_hair_cycle1.99797214
27MP0002118_abnormal_lipid_homeostasis1.97253037
28MP0009046_muscle_twitch1.96207600
29MP0006072_abnormal_retinal_apoptosis1.93130176
30MP0003195_calcinosis1.89111291
31MP0001984_abnormal_olfaction1.87066899
32MP0003787_abnormal_imprinting1.86929762
33MP0002876_abnormal_thyroid_physiology1.86218718
34MP0001919_abnormal_reproductive_system1.85339578
35MP0005174_abnormal_tail_pigmentation1.83975686
36MP0003880_abnormal_central_pattern1.83904237
37MP0000566_synostosis1.82174293
38MP0002736_abnormal_nociception_after1.80508682
39MP0006276_abnormal_autonomic_nervous1.80248635
40MP0001986_abnormal_taste_sensitivity1.77846778
41MP0003806_abnormal_nucleotide_metabolis1.74386136
42MP0000920_abnormal_myelination1.71476147
43MP0009745_abnormal_behavioral_response1.70690456
44MP0001486_abnormal_startle_reflex1.70578004
45MP0000383_abnormal_hair_follicle1.68979935
46MP0003868_abnormal_feces_composition1.68978286
47MP0000609_abnormal_liver_physiology1.64421249
48MP0004130_abnormal_muscle_cell1.63135774
49MP0003436_decreased_susceptibility_to1.59648414
50MP0010386_abnormal_urinary_bladder1.59265992
51MP0005389_reproductive_system_phenotype1.58131571
52MP0001666_abnormal_nutrient_absorption1.57877284
53MP0001529_abnormal_vocalization1.57620726
54MP0002138_abnormal_hepatobiliary_system1.57059532
55MP0002837_dystrophic_cardiac_calcinosis1.55955067
56MP0008058_abnormal_DNA_repair1.55728048
57MP0005171_absent_coat_pigmentation1.55549794
58MP0005464_abnormal_platelet_physiology1.55517543
59MP0005387_immune_system_phenotype1.54506995
60MP0001790_abnormal_immune_system1.54506995
61MP0008872_abnormal_physiological_respon1.50394652
62MP0004510_myositis1.50005246
63MP0002751_abnormal_autonomic_nervous1.49930202
64MP0001764_abnormal_homeostasis1.45846135
65MP0002272_abnormal_nervous_system1.43656648
66MP0004019_abnormal_vitamin_homeostasis1.42966285
67MP0005584_abnormal_enzyme/coenzyme_acti1.41784862
68MP0004147_increased_porphyrin_level1.41379095
69MP0002638_abnormal_pupillary_reflex1.40275856
70MP0003646_muscle_fatigue1.40145678
71MP0005058_abnormal_lysosome_morphology1.36974101
72MP0003300_gastrointestinal_ulcer1.35954817
73MP0003718_maternal_effect1.35667674
74MP0004142_abnormal_muscle_tone1.35420634
75MP0010234_abnormal_vibrissa_follicle1.34305194
76MP0000015_abnormal_ear_pigmentation1.33668965
77MP0001800_abnormal_humoral_immune1.28539043
78MP0000631_abnormal_neuroendocrine_gland1.27397760
79MP0002735_abnormal_chemical_nociception1.26381682
80MP0002419_abnormal_innate_immunity1.26081656
81MP0002938_white_spotting1.25731781
82MP0002653_abnormal_ependyma_morphology1.25383311
83MP0004043_abnormal_pH_regulation1.23214480
84MP0004742_abnormal_vestibular_system1.20968457
85MP0005535_abnormal_body_temperature1.20671073
86MP0001835_abnormal_antigen_presentation1.19376227
87MP0005084_abnormal_gallbladder_morpholo1.19122686
88MP0006054_spinal_hemorrhage1.19033858
89MP0003136_yellow_coat_color1.16025700
90MP0001664_abnormal_digestion1.15882175
91MP0005379_endocrine/exocrine_gland_phen1.15815681
92MP0009780_abnormal_chondrocyte_physiolo1.14351876
93MP0008961_abnormal_basal_metabolism1.14239102
94MP0005075_abnormal_melanosome_morpholog1.14104796
95MP0004885_abnormal_endolymph1.12065896
96MP0005000_abnormal_immune_tolerance1.12027945
97MP0005319_abnormal_enzyme/_coenzyme1.11100477
98MP0001970_abnormal_pain_threshold1.11026187
99MP0010678_abnormal_skin_adnexa1.10274658
100MP0003075_altered_response_to1.09691890
101MP0002452_abnormal_antigen_presenting1.09120678
102MP0004215_abnormal_myocardial_fiber1.08606101
103MP0009643_abnormal_urine_homeostasis1.08201799
104MP0001765_abnormal_ion_homeostasis1.08132535
105MP0008469_abnormal_protein_level1.07392350
106MP0004924_abnormal_behavior1.06946877
107MP0005386_behavior/neurological_phenoty1.06946877
108MP0002160_abnormal_reproductive_system1.05882303
109MP0004185_abnormal_adipocyte_glucose1.05830610
110MP0002557_abnormal_social/conspecific_i1.05579592
111MP0005025_abnormal_response_to1.02955897
112MP0002163_abnormal_gland_morphology1.01643943
113MP0003656_abnormal_erythrocyte_physiolo1.01395102
114MP0009763_increased_sensitivity_to1.00415090
115MP0002928_abnormal_bile_duct0.99537663
116MP0001485_abnormal_pinna_reflex0.98774078
117MP0002733_abnormal_thermal_nociception0.98694237
118MP0002067_abnormal_sensory_capabilities0.98614695
119MP0006292_abnormal_olfactory_placode0.97348086
120MP0002723_abnormal_immune_serum0.97284502
121MP0002064_seizures0.96162158
122MP0001440_abnormal_grooming_behavior0.95692238
123MP0002971_abnormal_brown_adipose0.94783075
124MP0005195_abnormal_posterior_eye0.94620744
125MP0002095_abnormal_skin_pigmentation0.94141399
126MP0003705_abnormal_hypodermis_morpholog0.94062774
127MP0005166_decreased_susceptibility_to0.91799615
128MP0001533_abnormal_skeleton_physiology0.91637555
129MP0005451_abnormal_body_composition0.91613927
130MP0003937_abnormal_limbs/digits/tail_de0.91099753
131MP0001324_abnormal_eye_pigmentation0.91037488
132MP0002752_abnormal_somatic_nervous0.90671168
133MP0000778_abnormal_nervous_system0.90596110
134MP0005666_abnormal_adipose_tissue0.90337881
135MP0008995_early_reproductive_senescence0.89145274
136MP0002234_abnormal_pharynx_morphology0.89112834
137MP0003635_abnormal_synaptic_transmissio0.88632708
138MP0008874_decreased_physiological_sensi0.88455506
139MP0006082_CNS_inflammation0.87687192
140MP0004484_altered_response_of0.87156672
141MP0003633_abnormal_nervous_system0.86390955
142MP0001963_abnormal_hearing_physiology0.86298552
143MP0003011_delayed_dark_adaptation0.86243105
144MP0000685_abnormal_immune_system0.85957633
145MP0002229_neurodegeneration0.84525148
146MP0001845_abnormal_inflammatory_respons0.84466330
147MP0000026_abnormal_inner_ear0.84011316
148MP0003121_genomic_imprinting0.83661401
149MP0003698_abnormal_male_reproductive0.83126044
150MP0003634_abnormal_glial_cell0.82504196
151MP0001929_abnormal_gametogenesis0.81710550
152MP0002090_abnormal_vision0.81124854
153MP0005367_renal/urinary_system_phenotyp0.81112147
154MP0000516_abnormal_urinary_system0.81112147
155MP0004133_heterotaxia0.80914538
156MP0002420_abnormal_adaptive_immunity0.80289125
157MP0001819_abnormal_immune_cell0.79528311
158MP0002136_abnormal_kidney_physiology0.79469773
159MP0000598_abnormal_liver_morphology0.79390906
160MP0005670_abnormal_white_adipose0.77078347
161MP0003950_abnormal_plasma_membrane0.76503459
162MP0010368_abnormal_lymphatic_system0.75027384
163MP0003045_fibrosis0.74811327
164MP0005310_abnormal_salivary_gland0.73112794
165MP0003724_increased_susceptibility_to0.73025785
166MP0001881_abnormal_mammary_gland0.72767975
167MP0003183_abnormal_peptide_metabolism0.72524969
168MP0005647_abnormal_sex_gland0.72322364
169MP0005334_abnormal_fat_pad0.70972041
170MP0001501_abnormal_sleep_pattern0.70916472
171MP0009764_decreased_sensitivity_to0.70886734
172MP0004947_skin_inflammation0.70762650
173MP0003631_nervous_system_phenotype0.68252718
174MP0005167_abnormal_blood-brain_barrier0.68096164
175MP0009642_abnormal_blood_homeostasis0.67627302
176MP0004859_abnormal_synaptic_plasticity0.66800521
177MP0004134_abnormal_chest_morphology0.64691596
178MP0002254_reproductive_system_inflammat0.62026178
179MP0002572_abnormal_emotion/affect_behav0.60954794
180MP0009785_altered_susceptibility_to0.60761530
181MP0002909_abnormal_adrenal_gland0.59497055
182MP0001958_emphysema0.59206447
183MP0003632_abnormal_nervous_system0.58570859
184MP0000343_altered_response_to0.57996495
185MP0009765_abnormal_xenobiotic_induced0.57878312
186MP0002078_abnormal_glucose_homeostasis0.57451853

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.13767741
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.82488296
3Xanthomatosis (HP:0000991)4.52137013
4Pancreatic cysts (HP:0001737)4.31795112
5Intrahepatic cholestasis (HP:0001406)4.31538552
6Hyperlipoproteinemia (HP:0010980)4.07807676
7Pancreatic fibrosis (HP:0100732)4.03965805
8Complement deficiency (HP:0004431)4.02589383
9Joint hemorrhage (HP:0005261)3.91136177
10True hermaphroditism (HP:0010459)3.89191804
11Abnormality of midbrain morphology (HP:0002418)3.83402551
12Molar tooth sign on MRI (HP:0002419)3.83402551
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81992250
14Neurofibrillary tangles (HP:0002185)3.75419299
15Nephronophthisis (HP:0000090)3.55696527
16Congenital stationary night blindness (HP:0007642)3.43018231
17Prolonged partial thromboplastin time (HP:0003645)3.37245992
18Medial flaring of the eyebrow (HP:0010747)3.32676567
19Abnormality of the renal cortex (HP:0011035)3.26839407
20Epidermoid cyst (HP:0200040)3.26516396
21Hyperventilation (HP:0002883)3.25907925
22Abnormality of complement system (HP:0005339)3.25723565
23Large for gestational age (HP:0001520)3.25670878
24Abnormality of glutamine family amino acid metabolism (HP:0010902)3.21200270
25Abnormality of the renal medulla (HP:0100957)3.18351206
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.16927670
27Cerebral inclusion bodies (HP:0100314)3.13257809
28Chronic hepatic failure (HP:0100626)3.08027014
29Ketosis (HP:0001946)3.06219837
30Systemic lupus erythematosus (HP:0002725)3.03443690
31Gaze-evoked nystagmus (HP:0000640)3.01980407
32Recurrent gram-negative bacterial infections (HP:0005420)3.01158197
33Mitral stenosis (HP:0001718)3.00009604
34Anterior segment dysgenesis (HP:0007700)2.99428778
35Conjugated hyperbilirubinemia (HP:0002908)2.93985427
36Abnormality of the common coagulation pathway (HP:0010990)2.92987576
37Attenuation of retinal blood vessels (HP:0007843)2.92560701
38Hyperammonemia (HP:0001987)2.90864836
39Nasal polyposis (HP:0100582)2.90788918
40Dynein arm defect of respiratory motile cilia (HP:0012255)2.89054152
41Absent/shortened dynein arms (HP:0200106)2.89054152
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.87624000
43Myocardial infarction (HP:0001658)2.87460495
44Vascular calcification (HP:0004934)2.81335591
45Tubular atrophy (HP:0000092)2.80737573
46Fat malabsorption (HP:0002630)2.77885037
47Hypobetalipoproteinemia (HP:0003563)2.77229922
48Broad-based gait (HP:0002136)2.69485043
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.64858557
50Bundle branch block (HP:0011710)2.64043270
51Increased cerebral lipofuscin (HP:0011813)2.63977114
52Abolished electroretinogram (ERG) (HP:0000550)2.59562888
53Vacuolated lymphocytes (HP:0001922)2.58827168
54Abnormal rod and cone electroretinograms (HP:0008323)2.57640144
55Gait imbalance (HP:0002141)2.57601006
56Amyloidosis (HP:0011034)2.57246219
57Congenital primary aphakia (HP:0007707)2.56409502
58Rhinitis (HP:0012384)2.56193407
59Loss of speech (HP:0002371)2.55005241
60Bile duct proliferation (HP:0001408)2.54757112
61Abnormal biliary tract physiology (HP:0012439)2.54757112
62Cystic liver disease (HP:0006706)2.53649586
63Polydipsia (HP:0001959)2.51729842
64Abnormal drinking behavior (HP:0030082)2.51729842
65Sensorimotor neuropathy (HP:0007141)2.48978002
66Cardiovascular calcification (HP:0011915)2.48959738
67Renal cortical cysts (HP:0000803)2.47778838
68Spastic tetraparesis (HP:0001285)2.47510147
69Adactyly (HP:0009776)2.45504319
70Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.43891224
71Abnormality of the nasal mucosa (HP:0000433)2.43707601
72Abnormality of macular pigmentation (HP:0008002)2.43507466
73Duplicated collecting system (HP:0000081)2.42010418
74Abnormality of the renal collecting system (HP:0004742)2.39459258
75Hypoalphalipoproteinemia (HP:0003233)2.38662669
76Methylmalonic acidemia (HP:0002912)2.38659203
77Nephrogenic diabetes insipidus (HP:0009806)2.38021442
78Prostate neoplasm (HP:0100787)2.37878481
79Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37313584
80Hydroxyprolinuria (HP:0003080)2.37041543
81Abnormality of proline metabolism (HP:0010907)2.37041543
82Aplasia/Hypoplasia of the tongue (HP:0010295)2.35934610
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.35451521
84Lissencephaly (HP:0001339)2.33233763
85Decreased central vision (HP:0007663)2.33066249
86Severe muscular hypotonia (HP:0006829)2.32063199
87Methylmalonic aciduria (HP:0012120)2.31238802
88Buphthalmos (HP:0000557)2.30673035
89Febrile seizures (HP:0002373)2.30513305
90Congenital hepatic fibrosis (HP:0002612)2.30357009
91Hypothermia (HP:0002045)2.30137166
92Axonal loss (HP:0003447)2.28733856
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.27930820
94Abnormality of methionine metabolism (HP:0010901)2.27476928
95Hypolipoproteinemia (HP:0010981)2.27393554
96Abnormality of serine family amino acid metabolism (HP:0010894)2.26833340
97Abnormality of glycine metabolism (HP:0010895)2.26833340
98Hypercholesterolemia (HP:0003124)2.26716453
99Increased corneal curvature (HP:0100692)2.24035930
100Keratoconus (HP:0000563)2.24035930
101Ketoacidosis (HP:0001993)2.23638629
102Sclerocornea (HP:0000647)2.23510654
103Chronic otitis media (HP:0000389)2.23053204
104Abnormal respiratory motile cilium physiology (HP:0012261)2.22511031
105Stomach cancer (HP:0012126)2.21709674
106Recurrent sinusitis (HP:0011108)2.21403924
107Glomerulonephritis (HP:0000099)2.18271631
108Genital tract atresia (HP:0001827)2.17237426
109Pulmonary embolism (HP:0002204)2.16987775
110Spontaneous abortion (HP:0005268)2.16159009
111Hyperglycinemia (HP:0002154)2.15523721
112Pendular nystagmus (HP:0012043)2.15469018
113Hemiparesis (HP:0001269)2.15424084
114Progressive cerebellar ataxia (HP:0002073)2.15070461
115Agammaglobulinemia (HP:0004432)2.15031407
116Anencephaly (HP:0002323)2.12453658
117Gingival bleeding (HP:0000225)2.11774737
118Slow saccadic eye movements (HP:0000514)2.11660286
119Type II lissencephaly (HP:0007260)2.11196460
120Steatorrhea (HP:0002570)2.10799698
121Abnormality of the intrinsic pathway (HP:0010989)2.09963377
122Focal motor seizures (HP:0011153)2.08686501
123Abnormal ciliary motility (HP:0012262)2.07396444
124Vaginal atresia (HP:0000148)2.06108389
125Mucopolysacchariduria (HP:0008155)2.05983735
126Urinary glycosaminoglycan excretion (HP:0003541)2.05983735
127Cellulitis (HP:0100658)2.05191635
128Menorrhagia (HP:0000132)2.03877645
129Inability to walk (HP:0002540)2.03656523
130Gout (HP:0001997)2.03411479
131Tubulointerstitial nephritis (HP:0001970)2.02103973
132Gastrointestinal stroma tumor (HP:0100723)2.01471396
133Chronic sinusitis (HP:0011109)2.00493366
134Polyuria (HP:0000103)2.00458799
135Widely spaced teeth (HP:0000687)1.99675433
136Cerebellar dysplasia (HP:0007033)1.99654586
137Abnormality of fatty-acid metabolism (HP:0004359)1.98742011
138Nephritis (HP:0000123)1.98163721
139Abnormal respiratory epithelium morphology (HP:0012253)1.97443996
140Abnormal respiratory motile cilium morphology (HP:0005938)1.97443996
141Absent rod-and cone-mediated responses on ERG (HP:0007688)1.97024981
142Postaxial foot polydactyly (HP:0001830)1.96595889
143Intestinal atresia (HP:0011100)1.96450953
144Tubulointerstitial fibrosis (HP:0005576)1.95822746
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.95800585
146Progressive inability to walk (HP:0002505)1.95201077
147Paraparesis (HP:0002385)1.92931724
148Polymicrogyria (HP:0002126)1.92773818
149Increased CSF lactate (HP:0002490)1.92478295
150Absent speech (HP:0001344)1.91570920
151Furrowed tongue (HP:0000221)1.91062707
152Impaired platelet aggregation (HP:0003540)1.90772080
153Abnormal platelet function (HP:0011869)1.90772080
154Bony spicule pigmentary retinopathy (HP:0007737)1.90059281
155Tubulointerstitial abnormality (HP:0001969)1.89053765
156Supranuclear gaze palsy (HP:0000605)1.88376633
157Hypoplastic pelvis (HP:0008839)1.87996090
158Occipital encephalocele (HP:0002085)1.87605509
159Postaxial hand polydactyly (HP:0001162)1.86899760
160Congenital sensorineural hearing impairment (HP:0008527)1.86650148
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85532147
162Abnormality of alanine metabolism (HP:0010916)1.85532147
163Hyperalaninemia (HP:0003348)1.85532147
164Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85071599
165Astigmatism (HP:0000483)1.83956785
166Abnormality of saccadic eye movements (HP:0000570)1.83432244
167Male pseudohermaphroditism (HP:0000037)1.83364429
168Fair hair (HP:0002286)1.83118007
169Focal seizures (HP:0007359)1.83007562
170Abnormality of macrophages (HP:0004311)1.82386665
171Acute necrotizing encephalopathy (HP:0006965)1.82358233
172Retinitis pigmentosa (HP:0000510)1.81790399
173Clubbing of toes (HP:0100760)1.81202727
174Recurrent bronchitis (HP:0002837)1.81200116
175Thyroid-stimulating hormone excess (HP:0002925)1.81197118
176Progressive macrocephaly (HP:0004481)1.80763489
177Abnormality of pyrimidine metabolism (HP:0004353)1.80420611
178Pachygyria (HP:0001302)1.80372975
179Aplasia/Hypoplasia of the fovea (HP:0008060)1.80145099
180Hypoplasia of the fovea (HP:0007750)1.80145099
181Abnormality of nucleobase metabolism (HP:0010932)1.80122656
182Abnormality of purine metabolism (HP:0004352)1.79973678
183Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79199803
184Abnormality of polysaccharide metabolism (HP:0011012)1.79199803
185Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79199803
186Confusion (HP:0001289)1.78628880
187Abnormality of the labia minora (HP:0012880)1.78383681
188Brushfield spots (HP:0001088)1.77455911
189Abnormality of the fovea (HP:0000493)1.73454605

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK25.70374484
2PIK3CG5.08362525
3MAP4K13.49492995
4MKNK13.35717365
5MAP3K143.18647347
6MAP4K23.13588503
7MAP3K132.83622386
8WNK32.83134835
9BMPR1B2.73850211
10ADRBK22.67919063
11RIPK42.43640797
12TRIM282.27174887
13MAP3K102.23922787
14TRIB32.22865534
15NUAK12.21445785
16PDK32.06650815
17PDK42.06650815
18EPHB11.99420860
19MAP3K41.98553170
20ZAK1.95041851
21CSF1R1.92440602
22ACVR1B1.90655168
23SIK11.89162393
24CASK1.88294778
25GRK11.86787929
26TAOK11.76163339
27BCKDK1.75613605
28MAPK131.71218962
29SIK21.70976904
30BLK1.68282528
31MUSK1.65590202
32EPHA41.62571145
33KIT1.62090119
34BCR1.54877406
35PTK2B1.45801819
36TNIK1.42653810
37PKN11.29697567
38MAP2K71.28940291
39GRK61.28367893
40PAK31.21877351
41JAK11.18016712
42DYRK1A1.16781943
43PLK21.16260084
44PRKCQ1.16224495
45FGFR41.12643654
46MARK11.10498488
47PDK21.09454166
48TYK21.09289666
49TXK1.07673934
50TAOK21.07609127
51MAP3K111.06524340
52MST41.04521739
53TBK11.03306297
54ERN11.02868850
55MAP2K21.02180506
56SYK0.99804367
57HCK0.99292440
58EIF2AK30.98610890
59CSK0.98264989
60STK390.97647292
61FES0.97401446
62PRKCH0.95956080
63TGFBR20.95419434
64MAP3K30.95069522
65PKN20.94427511
66PDK10.93937427
67PRKCE0.93799489
68ERBB30.92132838
69OXSR10.91295389
70LRRK20.90401448
71IRAK30.87873803
72ADRBK10.87495198
73FGFR20.87375266
74RET0.86450720
75PNCK0.84426599
76CAMK1G0.83304716
77CSNK1G20.81437337
78STK110.80259521
79FYN0.80244900
80TEC0.78730414
81PINK10.78291720
82DAPK20.77892047
83PTK60.77380716
84FER0.77133403
85KSR20.77033319
86CSNK1G10.76450757
87NTRK30.75911098
88MAP3K90.74382693
89TLK10.73657195
90MAP3K20.73302189
91MATK0.73133743
92MAP2K40.72555180
93PIK3CA0.72362587
94MAPK40.72314487
95MARK30.70971410
96IKBKB0.70943877
97FGR0.70427602
98PRKCG0.70011230
99PRKD10.69582936
100DYRK20.69582748
101CSNK1G30.69203839
102JAK20.68343051
103TNK20.66517483
104PDPK10.65191425
105LCK0.64576089
106BMX0.64443971
107STK38L0.63766593
108IKBKE0.63630111
109IRAK10.63377162
110AKT30.63087633
111MAP3K50.62935189
112BTK0.62862303
113JAK30.62608035
114ROCK20.61846016
115FRK0.60967825
116INSRR0.60879554
117CAMKK20.59976433
118CSNK1A1L0.59893899
119SGK30.59559865
120MAPK70.56904654
121PLK30.56854289
122STK100.56364314
123TGFBR10.55236985
124TAOK30.55132614
125GSK3A0.54751677
126WNK10.54686332
127CCNB10.54541385
128PAK60.53976895
129SGK2230.52257082
130SGK4940.52257082
131ABL20.52207394
132GRK70.50651240
133ITK0.50509821
134PDGFRB0.50094758
135FLT30.49966659
136TTN0.49656976
137STK240.49362252
138CLK10.48902801
139WNK40.48858649
140MAPK120.47890253
141PRKCZ0.47093797
142MAP3K70.46799806
143ABL10.46728686
144CAMK2A0.46304325
145MAP2K30.45550555
146CHEK20.44037694
147SRPK10.43624964
148STK30.42545450
149LYN0.41990418
150VRK10.41526957
151PRKACG0.41481186
152CSNK1A10.40919366
153DYRK1B0.40651806
154SIK30.39862413
155KSR10.39803152
156IGF1R0.39237405
157ALK0.38659432
158GRK50.37769901
159WEE10.37661281
160TIE10.37589735
161SGK10.37511337
162TRPM70.36730539
163PRKAA20.36720577
164EPHA30.35924377
165PRKACA0.35083906
166PLK40.34412871
167BRSK20.34067689
168DYRK30.31976720
169MAP3K120.29589720
170NLK0.29476000
171CAMK10.29069236
172MINK10.28128650
173MAP2K60.27724194
174BMPR20.27158349
175PLK10.26182790
176CSNK1D0.25904308

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.73976100
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.62361644
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.34483294
4Phototransduction_Homo sapiens_hsa047442.63501760
5Protein export_Homo sapiens_hsa030602.34382217
6Arginine biosynthesis_Homo sapiens_hsa002202.26283666
7Complement and coagulation cascades_Homo sapiens_hsa046102.22140955
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19819739
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.18394584
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.09899394
11Nicotine addiction_Homo sapiens_hsa050332.08502565
12SNARE interactions in vesicular transport_Homo sapiens_hsa041302.05760304
13Staphylococcus aureus infection_Homo sapiens_hsa051501.98362864
14Taste transduction_Homo sapiens_hsa047421.98309871
15Fatty acid degradation_Homo sapiens_hsa000711.95969262
16PPAR signaling pathway_Homo sapiens_hsa033201.93540319
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.91175827
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.90753397
19Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80849957
20Fanconi anemia pathway_Homo sapiens_hsa034601.80207839
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78833366
22Basal transcription factors_Homo sapiens_hsa030221.78665035
23Histidine metabolism_Homo sapiens_hsa003401.75993631
24Tryptophan metabolism_Homo sapiens_hsa003801.70443228
25beta-Alanine metabolism_Homo sapiens_hsa004101.68310147
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.67275398
27Homologous recombination_Homo sapiens_hsa034401.66072154
28Propanoate metabolism_Homo sapiens_hsa006401.64416139
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62731237
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61447692
31Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.61034391
32Bile secretion_Homo sapiens_hsa049761.56832840
33RNA polymerase_Homo sapiens_hsa030201.53897786
34Pentose and glucuronate interconversions_Homo sapiens_hsa000401.52783031
35Peroxisome_Homo sapiens_hsa041461.52496067
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52243870
37Ether lipid metabolism_Homo sapiens_hsa005651.49026560
38Butanoate metabolism_Homo sapiens_hsa006501.48212744
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48072435
40Oxidative phosphorylation_Homo sapiens_hsa001901.46877940
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.44308577
42Fatty acid metabolism_Homo sapiens_hsa012121.39531180
43Sulfur metabolism_Homo sapiens_hsa009201.38633187
44B cell receptor signaling pathway_Homo sapiens_hsa046621.35625535
45Chemical carcinogenesis_Homo sapiens_hsa052041.29297891
46Caffeine metabolism_Homo sapiens_hsa002321.26041910
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.24533049
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.24397661
49Morphine addiction_Homo sapiens_hsa050321.22204391
50Retinol metabolism_Homo sapiens_hsa008301.17759477
51Regulation of autophagy_Homo sapiens_hsa041401.10074056
52Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08608977
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.08203685
54Phenylalanine metabolism_Homo sapiens_hsa003601.07600375
55Collecting duct acid secretion_Homo sapiens_hsa049661.05234954
56ABC transporters_Homo sapiens_hsa020101.05113720
57Non-homologous end-joining_Homo sapiens_hsa034501.04838382
58Carbohydrate digestion and absorption_Homo sapiens_hsa049731.04690149
59Parkinsons disease_Homo sapiens_hsa050121.04360235
60Pyruvate metabolism_Homo sapiens_hsa006201.00472391
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99741305
62Fatty acid elongation_Homo sapiens_hsa000620.96336207
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.92125547
64Serotonergic synapse_Homo sapiens_hsa047260.91638289
65Proteasome_Homo sapiens_hsa030500.90501422
66Glycerolipid metabolism_Homo sapiens_hsa005610.90482495
67GABAergic synapse_Homo sapiens_hsa047270.90199360
68Circadian entrainment_Homo sapiens_hsa047130.89690721
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.88081916
70Arachidonic acid metabolism_Homo sapiens_hsa005900.84856691
71One carbon pool by folate_Homo sapiens_hsa006700.84558550
72RNA degradation_Homo sapiens_hsa030180.83847834
73Osteoclast differentiation_Homo sapiens_hsa043800.82317283
74Huntingtons disease_Homo sapiens_hsa050160.80976164
75Fat digestion and absorption_Homo sapiens_hsa049750.80635313
76Glutamatergic synapse_Homo sapiens_hsa047240.79694898
77Fatty acid biosynthesis_Homo sapiens_hsa000610.76909761
78Sphingolipid metabolism_Homo sapiens_hsa006000.76453124
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75961889
80Starch and sucrose metabolism_Homo sapiens_hsa005000.75190569
81Tyrosine metabolism_Homo sapiens_hsa003500.73883013
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.71659540
83Selenocompound metabolism_Homo sapiens_hsa004500.65634543
84Ovarian steroidogenesis_Homo sapiens_hsa049130.63936084
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63000347
86Vitamin B6 metabolism_Homo sapiens_hsa007500.62031763
87Insulin secretion_Homo sapiens_hsa049110.61285081
88Metabolic pathways_Homo sapiens_hsa011000.60300987
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.59044447
90Purine metabolism_Homo sapiens_hsa002300.58721541
91Vitamin digestion and absorption_Homo sapiens_hsa049770.58631815
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58377553
93Dopaminergic synapse_Homo sapiens_hsa047280.58304080
94Alzheimers disease_Homo sapiens_hsa050100.58194120
95Insulin resistance_Homo sapiens_hsa049310.57288461
96Carbon metabolism_Homo sapiens_hsa012000.56640805
97Biosynthesis of amino acids_Homo sapiens_hsa012300.54134210
98Calcium signaling pathway_Homo sapiens_hsa040200.54053065
99Type II diabetes mellitus_Homo sapiens_hsa049300.53207070
100Long-term depression_Homo sapiens_hsa047300.51671592
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49755365
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.49408460
103Arginine and proline metabolism_Homo sapiens_hsa003300.48064915
104Lysine degradation_Homo sapiens_hsa003100.46052724
105Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46005861
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45552852
107Circadian rhythm_Homo sapiens_hsa047100.45243189
108Folate biosynthesis_Homo sapiens_hsa007900.44123340
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.44085101
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.41804618
111Dorso-ventral axis formation_Homo sapiens_hsa043200.41461023
112Steroid biosynthesis_Homo sapiens_hsa001000.41335968
113Glucagon signaling pathway_Homo sapiens_hsa049220.41029989
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40918071
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40341034
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39668458
117Olfactory transduction_Homo sapiens_hsa047400.38321923
118Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37615358
119Asthma_Homo sapiens_hsa053100.36987936
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.36802595
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35374654
122Prion diseases_Homo sapiens_hsa050200.34949975
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34734701
124Renal cell carcinoma_Homo sapiens_hsa052110.33022680
125Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.32984075
126Pentose phosphate pathway_Homo sapiens_hsa000300.32432453
127Cocaine addiction_Homo sapiens_hsa050300.32137841
128Lysosome_Homo sapiens_hsa041420.32027419
129Renin secretion_Homo sapiens_hsa049240.31859545
130Mineral absorption_Homo sapiens_hsa049780.31644126
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31621049
132Cholinergic synapse_Homo sapiens_hsa047250.31515647
133T cell receptor signaling pathway_Homo sapiens_hsa046600.31209214
134Leishmaniasis_Homo sapiens_hsa051400.31113467
135VEGF signaling pathway_Homo sapiens_hsa043700.30689871
136Non-small cell lung cancer_Homo sapiens_hsa052230.30623723
137Acute myeloid leukemia_Homo sapiens_hsa052210.30185079
138Glutathione metabolism_Homo sapiens_hsa004800.30135396
139Pyrimidine metabolism_Homo sapiens_hsa002400.29961614
140Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29600608
141Amoebiasis_Homo sapiens_hsa051460.29492420
142Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.29421328
143Pertussis_Homo sapiens_hsa051330.29034045
144Glioma_Homo sapiens_hsa052140.28636515
145Pancreatic cancer_Homo sapiens_hsa052120.28514180
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28453230
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27995386
148Amphetamine addiction_Homo sapiens_hsa050310.27606145
149Gastric acid secretion_Homo sapiens_hsa049710.27565353
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26649119
151Salivary secretion_Homo sapiens_hsa049700.26575460
152Nucleotide excision repair_Homo sapiens_hsa034200.26243302
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25549164
154alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25127438
155Platelet activation_Homo sapiens_hsa046110.25031805
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.24117636
157Linoleic acid metabolism_Homo sapiens_hsa005910.21627567
158Maturity onset diabetes of the young_Homo sapiens_hsa049500.21503380
159Chemokine signaling pathway_Homo sapiens_hsa040620.21309531

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