FAM153A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.73735092
2response to pheromone (GO:0019236)9.29048706
3sperm capacitation (GO:0048240)8.15685153
4plasma membrane fusion (GO:0045026)7.47791570
5spermatid development (GO:0007286)6.57904556
6single strand break repair (GO:0000012)6.56717784
7multicellular organism reproduction (GO:0032504)6.47539124
8calcium ion-dependent exocytosis (GO:0017156)6.35970431
9protein targeting to Golgi (GO:0000042)6.11849517
10DNA packaging (GO:0006323)6.07327828
11establishment of protein localization to Golgi (GO:0072600)6.06026509
12sperm-egg recognition (GO:0035036)6.05613355
13chromosome condensation (GO:0030261)6.03172703
14phosphatidylethanolamine biosynthetic process (GO:0006646)5.97533906
15microtubule depolymerization (GO:0007019)5.94667864
16reproduction (GO:0000003)5.79312974
17protein polyglutamylation (GO:0018095)5.73967615
18spermatid nucleus differentiation (GO:0007289)5.73111447
19retrograde transport, vesicle recycling within Golgi (GO:0000301)5.65440474
20positive regulation of Rab GTPase activity (GO:0032851)5.60969795
21regulation of Rab GTPase activity (GO:0032313)5.60969795
22phosphatidylethanolamine metabolic process (GO:0046337)5.55494119
23microtubule polymerization or depolymerization (GO:0031109)5.52200839
24rRNA methylation (GO:0031167)5.45145935
25negative regulation of inclusion body assembly (GO:0090084)5.34242564
26centriole replication (GO:0007099)5.28542696
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.21275478
28cell-cell recognition (GO:0009988)5.12895631
29axonemal dynein complex assembly (GO:0070286)5.05842307
30spermatogenesis (GO:0007283)4.96886214
31male gamete generation (GO:0048232)4.95128643
32regulation of transcription involved in cell fate commitment (GO:0060850)4.94191239
33cellular ketone body metabolic process (GO:0046950)4.94030740
34binding of sperm to zona pellucida (GO:0007339)4.87150466
35cilium or flagellum-dependent cell motility (GO:0001539)4.85433470
36regulation of cilium movement (GO:0003352)4.85162829
37sexual reproduction (GO:0019953)4.76179693
38microtubule severing (GO:0051013)4.57662168
39gamete generation (GO:0007276)4.51821746
40centriole assembly (GO:0098534)4.47085067
41RNA destabilization (GO:0050779)4.47005466
42rRNA modification (GO:0000154)4.46194130
43protein localization to Golgi apparatus (GO:0034067)4.44820086
44ketone body metabolic process (GO:1902224)4.35594983
45cell wall macromolecule metabolic process (GO:0044036)4.17859494
46single fertilization (GO:0007338)4.08112488
47Golgi to endosome transport (GO:0006895)4.03922589
48motile cilium assembly (GO:0044458)3.90381343
49organic cation transport (GO:0015695)3.89267056
50cell wall macromolecule catabolic process (GO:0016998)3.88443329
51epithelial cilium movement (GO:0003351)3.85200312
52germ cell development (GO:0007281)3.71045701
53regulation of inclusion body assembly (GO:0090083)3.70592728
54coenzyme catabolic process (GO:0009109)3.69563979
55chromatin silencing (GO:0006342)3.68851043
56multicellular organismal movement (GO:0050879)3.60147484
57musculoskeletal movement (GO:0050881)3.60147484
58regulation of centriole replication (GO:0046599)3.59695902
59multicellular organismal reproductive process (GO:0048609)3.59038438
60cellular process involved in reproduction in multicellular organism (GO:0022412)3.58801787
61regulation of microtubule-based movement (GO:0060632)3.52157987
62cilium movement (GO:0003341)3.46631308
63peptidyl-threonine dephosphorylation (GO:0035970)3.46140127
64cerebral cortex neuron differentiation (GO:0021895)3.43371823
65fertilization (GO:0009566)3.42549367
66seminiferous tubule development (GO:0072520)3.40850010
67negative regulation of Rho protein signal transduction (GO:0035024)3.27937598
68response to acidic pH (GO:0010447)3.24053548
69mast cell degranulation (GO:0043303)3.16010006
70mast cell activation involved in immune response (GO:0002279)3.16010006
71regulation of interleukin-13 production (GO:0032656)3.08771406
72epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.06372542
73nucleus organization (GO:0006997)3.02498464
74microtubule nucleation (GO:0007020)2.98447518
75NAD biosynthetic process (GO:0009435)2.88906802
76regulation of phosphoprotein phosphatase activity (GO:0043666)2.87681399
77membrane depolarization during action potential (GO:0086010)2.86080055
78regulation of T-helper 2 cell differentiation (GO:0045628)2.84106225
79cellular response to pH (GO:0071467)2.80061562
80DNA methylation involved in gamete generation (GO:0043046)2.78300982
81positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.77126583
82axoneme assembly (GO:0035082)2.74567856
83vesicle transport along microtubule (GO:0047496)2.73531569
84histone H3-K9 demethylation (GO:0033169)2.73490918
85positive regulation of guanylate cyclase activity (GO:0031284)2.69848798
86primary amino compound metabolic process (GO:1901160)2.68075827
87regulation of ARF GTPase activity (GO:0032312)2.64986104
88regulation of interleukin-5 production (GO:0032674)2.64923395
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.62975996
90regulation of guanylate cyclase activity (GO:0031282)2.62393487
91neuronal ion channel clustering (GO:0045161)2.62137724
92spinal cord motor neuron differentiation (GO:0021522)2.59913655
93detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.59460987
94alanine transport (GO:0032328)2.59307627
95male meiosis (GO:0007140)2.56811559
96positive regulation of action potential (GO:0045760)2.56573438
97cell recognition (GO:0008037)2.56049869
98histone mRNA catabolic process (GO:0071044)2.53606310
99acrosome reaction (GO:0007340)10.1926795
100sperm motility (GO:0030317)10.1515193

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human2.74800088
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.54875528
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.39111712
4DROSHA_22980978_ChIP-Seq_HELA_Human2.31570816
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.27229003
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.13443793
7TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06619432
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.06619432
9CTBP1_25329375_ChIP-Seq_LNCAP_Human2.06270981
10IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.94950395
11CBP_20019798_ChIP-Seq_JUKART_Human1.94950395
12VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.85927455
13ER_23166858_ChIP-Seq_MCF-7_Human1.77376050
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73681421
15UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.67395052
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.66421597
17AR_21572438_ChIP-Seq_LNCaP_Human1.66410304
18EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66245102
19TAF15_26573619_Chip-Seq_HEK293_Human1.66187085
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.64123679
21ERA_21632823_ChIP-Seq_H3396_Human1.63711507
22FUS_26573619_Chip-Seq_HEK293_Human1.63109733
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.60085413
24ZNF274_21170338_ChIP-Seq_K562_Hela1.57619142
25RUNX_20019798_ChIP-Seq_JUKART_Human1.55788669
26GBX2_23144817_ChIP-Seq_PC3_Human1.53801026
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.53739155
28NANOG_20526341_ChIP-Seq_ESCs_Human1.52065706
29AR_25329375_ChIP-Seq_VCAP_Human1.50656434
30REST_21632747_ChIP-Seq_MESCs_Mouse1.50550337
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.50030274
32ETV2_25802403_ChIP-Seq_MESCs_Mouse1.48290678
33MYC_19829295_ChIP-Seq_ESCs_Human1.45297255
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44846405
35SMAD4_21741376_ChIP-Seq_EPCs_Human1.44576895
36RAC3_21632823_ChIP-Seq_H3396_Human1.44357095
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.44290495
38OCT4_20526341_ChIP-Seq_ESCs_Human1.38552408
39ARNT_22903824_ChIP-Seq_MCF-7_Human1.38416769
40P300_19829295_ChIP-Seq_ESCs_Human1.38074401
41SMAD3_21741376_ChIP-Seq_EPCs_Human1.37279368
42EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.36793926
43TAF2_19829295_ChIP-Seq_ESCs_Human1.36112285
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.35530080
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.33034056
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29828207
47STAT3_23295773_ChIP-Seq_U87_Human1.29758761
48PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28664664
49BCL6_27268052_Chip-Seq_Bcells_Human1.27602422
50SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27439122
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26173383
52SMAD4_21799915_ChIP-Seq_A2780_Human1.25852738
53SMRT_27268052_Chip-Seq_Bcells_Human1.25640707
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24486288
55GATA3_21878914_ChIP-Seq_MCF-7_Human1.23998491
56PRDM14_20953172_ChIP-Seq_ESCs_Human1.23660497
57SMAD3_21741376_ChIP-Seq_ESCs_Human1.23651844
58CTCF_27219007_Chip-Seq_Bcells_Human1.22673466
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20512882
60TDRD3_21172665_ChIP-Seq_MCF-7_Human1.19689900
61KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19651789
62RUNX2_22187159_ChIP-Seq_PCA_Human1.19164980
63KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18784426
64E2F1_20622854_ChIP-Seq_HELA_Human1.18491441
65SMC4_20622854_ChIP-Seq_HELA_Human1.17571141
66NANOG_19829295_ChIP-Seq_ESCs_Human1.17073252
67SOX2_19829295_ChIP-Seq_ESCs_Human1.17073252
68EZH2_27294783_Chip-Seq_ESCs_Mouse1.14498309
69ETV1_20927104_ChIP-Seq_GIST48_Human1.13879251
70CTCF_20526341_ChIP-Seq_ESCs_Human1.12430852
71CBX2_22325352_ChIP-Seq_293T-Rex_Human1.12328233
72P300_27268052_Chip-Seq_Bcells_Human1.11687196
73TCF4_23295773_ChIP-Seq_U87_Human1.11472982
74PHF8_20622854_ChIP-Seq_HELA_Human1.09929512
75RBPJ_21746931_ChIP-Seq_IB4_Human1.09852055
76CEBPB_22108803_ChIP-Seq_LS180_Human1.09427544
77VDR_22108803_ChIP-Seq_LS180_Human1.08777192
78BCOR_27268052_Chip-Seq_Bcells_Human1.08748757
79TBL1_22424771_ChIP-Seq_293T_Human1.07342259
80HNFA_21074721_ChIP-Seq_CACO-2_Human1.06906556
81SMAD4_21741376_ChIP-Seq_HESCs_Human1.06623945
82NFYB_21822215_ChIP-Seq_K562_Human1.06496357
83ERG_20517297_ChIP-Seq_VCAP_Human1.06243064
84REST_18959480_ChIP-ChIP_MESCs_Mouse1.05691403
85MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05376972
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03962604
87P68_20966046_ChIP-Seq_HELA_Human1.03231270
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02096291
89CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.01700263
90TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.01650829
91P53_21459846_ChIP-Seq_SAOS-2_Human1.00696355
92TP63_22573176_ChIP-Seq_HFKS_Human1.00655470
93OCT1_27270436_Chip-Seq_PROSTATE_Human0.99419972
94GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98861997
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98756762
96GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98383396
97HOXB7_26014856_ChIP-Seq_BT474_Human0.98072225
98SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98042325
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.97252676
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96896409

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.48551598
2MP0005377_hearing/vestibular/ear_phenot4.29932036
3MP0003878_abnormal_ear_physiology4.29932036
4MP0003698_abnormal_male_reproductive3.57819160
5MP0005670_abnormal_white_adipose3.34891670
6MP0001348_abnormal_lacrimal_gland3.14090094
7MP0001929_abnormal_gametogenesis2.98685651
8MP0004859_abnormal_synaptic_plasticity2.72409005
9MP0001968_abnormal_touch/_nociception2.43395360
10MP0001486_abnormal_startle_reflex2.20703428
11MP0003880_abnormal_central_pattern2.12029568
12MP0002822_catalepsy2.00760872
13MP0005423_abnormal_somatic_nervous1.97943845
14MP0009745_abnormal_behavioral_response1.93482600
15MP0002735_abnormal_chemical_nociception1.90221411
16MP0002161_abnormal_fertility/fecundity1.87832538
17MP0005379_endocrine/exocrine_gland_phen1.76751310
18MP0001501_abnormal_sleep_pattern1.74648494
19MP0002132_abnormal_respiratory_system1.71998394
20MP0003635_abnormal_synaptic_transmissio1.71241191
21MP0008877_abnormal_DNA_methylation1.71196818
22MP0001485_abnormal_pinna_reflex1.66142699
23MP0003646_muscle_fatigue1.65759912
24MP0002272_abnormal_nervous_system1.64889112
25MP0009046_muscle_twitch1.57900350
26MP0000678_abnormal_parathyroid_gland1.57187394
27MP0003879_abnormal_hair_cell1.56092422
28MP0002572_abnormal_emotion/affect_behav1.53375610
29MP0002064_seizures1.51913009
30MP0008569_lethality_at_weaning1.49794665
31MP0004742_abnormal_vestibular_system1.43018640
32MP0005310_abnormal_salivary_gland1.42345389
33MP0002733_abnormal_thermal_nociception1.42111669
34MP0005551_abnormal_eye_electrophysiolog1.35722399
35MP0003718_maternal_effect1.34314796
36MP0002067_abnormal_sensory_capabilities1.33967258
37MP0002210_abnormal_sex_determination1.30412346
38MP0001765_abnormal_ion_homeostasis1.30196613
39MP0003011_delayed_dark_adaptation1.28201420
40MP0001905_abnormal_dopamine_level1.27740795
41MP0002734_abnormal_mechanical_nocicepti1.27309420
42MP0002234_abnormal_pharynx_morphology1.27132792
43MP0001970_abnormal_pain_threshold1.26273187
44MP0002138_abnormal_hepatobiliary_system1.25062653
45MP0002063_abnormal_learning/memory/cond1.24365745
46MP0004270_analgesia1.22601456
47MP0002229_neurodegeneration1.18409459
48MP0001963_abnormal_hearing_physiology1.16981364
49MP0002557_abnormal_social/conspecific_i1.15890709
50MP0003787_abnormal_imprinting1.10763267
51MP0000653_abnormal_sex_gland1.06216031
52MP0001145_abnormal_male_reproductive1.05927377
53MP0001440_abnormal_grooming_behavior1.05590280
54MP0002736_abnormal_nociception_after1.00354283
55MP0005535_abnormal_body_temperature0.99879630
56MP0004510_myositis0.96396438
57MP0004484_altered_response_of0.91177061
58MP0005253_abnormal_eye_physiology0.87465638
59MP0000955_abnormal_spinal_cord0.87227864
60MP0004085_abnormal_heartbeat0.87025808
61MP0005167_abnormal_blood-brain_barrier0.86361943
62MP0010386_abnormal_urinary_bladder0.84695766
63MP0003633_abnormal_nervous_system0.82963074
64MP0001984_abnormal_olfaction0.81935407
65MP0006276_abnormal_autonomic_nervous0.81134941
66MP0000026_abnormal_inner_ear0.78457153
67MP0005645_abnormal_hypothalamus_physiol0.76221995
68MP0002249_abnormal_larynx_morphology0.74247774
69MP0009115_abnormal_fat_cell0.74168290
70MP0002928_abnormal_bile_duct0.72317082
71MP0003631_nervous_system_phenotype0.72007276
72MP0002127_abnormal_cardiovascular_syste0.71307149
73MP0008872_abnormal_physiological_respon0.70988543
74MP0002282_abnormal_trachea_morphology0.70960989
75MP0005395_other_phenotype0.65291903
76MP0000681_abnormal_thyroid_gland0.62802861
77MP0005636_abnormal_mineral_homeostasis0.61964350
78MP0005646_abnormal_pituitary_gland0.61934006
79MP0004885_abnormal_endolymph0.61675631
80MP0008995_early_reproductive_senescence0.61061349
81MP0002693_abnormal_pancreas_physiology0.60878021
82MP0003172_abnormal_lysosome_physiology0.59948754
83MP0000569_abnormal_digit_pigmentation0.59108599
84MP0003137_abnormal_impulse_conducting0.58077007
85MP0002882_abnormal_neuron_morphology0.57566508
86MP0009764_decreased_sensitivity_to0.56087674
87MP0001986_abnormal_taste_sensitivity0.55432069
88MP0004811_abnormal_neuron_physiology0.52686744
89MP0004142_abnormal_muscle_tone0.52487698
90MP0005451_abnormal_body_composition0.52231480
91MP0008874_decreased_physiological_sensi0.52144130
92MP0004924_abnormal_behavior0.52038469
93MP0005386_behavior/neurological_phenoty0.52038469
94MP0001800_abnormal_humoral_immune0.50620097
95MP0008961_abnormal_basal_metabolism0.50069826
96MP0010329_abnormal_lipoprotein_level0.48070271
97MP0005671_abnormal_response_to0.47123409
98MP0002066_abnormal_motor_capabilities/c0.46567131
99MP0000230_abnormal_systemic_arterial0.46494850
100MP0001873_stomach_inflammation0.46255068

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.34156655
2Attenuation of retinal blood vessels (HP:0007843)5.26818480
3Absent/shortened dynein arms (HP:0200106)5.14764094
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.14764094
5Bony spicule pigmentary retinopathy (HP:0007737)4.75603749
6Abnormal rod and cone electroretinograms (HP:0008323)4.48747864
7Asymmetric septal hypertrophy (HP:0001670)4.28502439
8Abnormal ciliary motility (HP:0012262)4.07244078
9Hyperkalemia (HP:0002153)4.01347132
10Bell-shaped thorax (HP:0001591)4.00217111
11Chronic hepatic failure (HP:0100626)3.97169542
12Resting tremor (HP:0002322)3.91658526
13Abnormality of macular pigmentation (HP:0008002)3.90340403
14Abnormal respiratory motile cilium morphology (HP:0005938)3.87186140
15Abnormal respiratory epithelium morphology (HP:0012253)3.87186140
16Facial shape deformation (HP:0011334)3.83465320
17Potter facies (HP:0002009)3.83465320
18Abnormal respiratory motile cilium physiology (HP:0012261)3.82513166
19Progressive cerebellar ataxia (HP:0002073)3.81108986
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.77330723
21Hypoplastic ischia (HP:0003175)3.67133293
22Postural instability (HP:0002172)3.57293592
23Tubulointerstitial nephritis (HP:0001970)3.48766513
24Enlarged epiphyses (HP:0010580)3.48198234
25Male infertility (HP:0003251)3.45294641
26Infertility (HP:0000789)3.38303445
27Nephronophthisis (HP:0000090)3.31614076
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17178246
29Abnormality of the ischium (HP:0003174)3.15834405
30Abnormal drinking behavior (HP:0030082)3.13374981
31Polydipsia (HP:0001959)3.13374981
32Nasal polyposis (HP:0100582)3.10668692
33Abnormal urine output (HP:0012590)3.07841960
34Aplasia/Hypoplasia of the earlobes (HP:0009906)2.98136895
35Atonic seizures (HP:0010819)2.92579475
36Abnormality of the renal medulla (HP:0100957)2.89480455
37Impulsivity (HP:0100710)2.88365908
38Hypoplasia of the thymus (HP:0000778)2.86266469
39Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.84252042
40Abnormal spermatogenesis (HP:0008669)2.77910490
41Cone-rod dystrophy (HP:0000548)2.75925194
42Polyuria (HP:0000103)2.73546878
43Myokymia (HP:0002411)2.73425269
44Febrile seizures (HP:0002373)2.67566936
45Abnormality of renal excretion (HP:0011036)2.65717086
46Azoospermia (HP:0000027)2.57579895
47Rhinitis (HP:0012384)2.50983080
48Decreased central vision (HP:0007663)2.49580844
49Abnormality of potassium homeostasis (HP:0011042)2.48466934
50Double outlet right ventricle (HP:0001719)2.38616177
51Congenital malformation of the right heart (HP:0011723)2.38616177
52Focal motor seizures (HP:0011153)2.37018940
53Amelogenesis imperfecta (HP:0000705)2.35923199
54Abnormality of dental color (HP:0011073)2.33964679
55Abnormality of the nasal mucosa (HP:0000433)2.31462919
56Pancreatic fibrosis (HP:0100732)2.21181689
57Papilledema (HP:0001085)2.21059227
58Bronchiectasis (HP:0002110)2.18507151
59Truncal obesity (HP:0001956)2.14809812
60Epiphyseal dysplasia (HP:0002656)2.13292202
61Tubulointerstitial abnormality (HP:0001969)2.12414911
62Abnormality of the aortic arch (HP:0012303)2.11017826
63Stage 5 chronic kidney disease (HP:0003774)2.10533373
64Generalized aminoaciduria (HP:0002909)2.08140215
65Pancreatic cysts (HP:0001737)2.04377541
66Genetic anticipation (HP:0003743)2.01565173
67Portal hypertension (HP:0001409)1.98519080
68Gaze-evoked nystagmus (HP:0000640)1.97750178
69Unilateral renal agenesis (HP:0000122)1.97166440
70Hypochromic microcytic anemia (HP:0004840)1.95934176
71Tubular atrophy (HP:0000092)1.94866120
72Congenital sensorineural hearing impairment (HP:0008527)1.92217287
73Tetany (HP:0001281)1.91850725
74Renal dysplasia (HP:0000110)1.91320463
75Epileptic encephalopathy (HP:0200134)1.90147174
76Photophobia (HP:0000613)1.89484518
77Focal seizures (HP:0007359)1.85741934
78Insulin-resistant diabetes mellitus (HP:0000831)1.84523258
79Amblyopia (HP:0000646)1.83525008
80Widely patent fontanelles and sutures (HP:0004492)1.83247053
81Abnormality of the renal cortex (HP:0011035)1.82600403
82Occipital encephalocele (HP:0002085)1.81660345
83Abnormality of the costochondral junction (HP:0000919)1.81318237
84Bulbous nose (HP:0000414)1.77962624
85Abnormality of the hepatic vasculature (HP:0006707)1.77621387
86Type II lissencephaly (HP:0007260)1.76152383
87Optic nerve hypoplasia (HP:0000609)1.75314004
88Absence seizures (HP:0002121)1.74607527
89Abnormality of the pubic bones (HP:0003172)1.74144155
90Dialeptic seizures (HP:0011146)1.73512864
91Hypophosphatemic rickets (HP:0004912)1.72293679
92Hyponatremia (HP:0002902)1.72286343
93Abnormality of chloride homeostasis (HP:0011422)1.72139016
94Horizontal nystagmus (HP:0000666)1.69707580
95Recurrent pneumonia (HP:0006532)1.68384964
96Hyperthyroidism (HP:0000836)1.63899110
97Macular degeneration (HP:0000608)1.63733754
98Mixed hearing impairment (HP:0000410)1.63396686
99Hypokalemia (HP:0002900)1.63228862
100Cystic liver disease (HP:0006706)1.62979320

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK46.70308496
2TESK14.48348007
3DDR24.10985961
4PLK23.39146721
5STK383.32703674
6MAP4K23.32578650
7INSRR3.04679470
8FRK2.60115560
9MAPK151.93587824
10PRKD31.85637407
11STK38L1.78521686
12PDK11.72604148
13PNCK1.72509913
14CAMK1G1.70968122
15BRD41.63163138
16RIPK41.57854968
17WNK11.54519893
18NTRK31.53081952
19PTK2B1.51868946
20PIK3CG1.44384015
21PDPK11.44208633
22PINK11.28722675
23DAPK21.27066099
24UHMK11.24564354
25SIK21.22670150
26TXK1.15513417
27NEK61.14364050
28MAP3K91.07044156
29ADRBK21.01341168
30CAMK10.97852073
31TAOK30.92923831
32TNK20.92380329
33KSR20.90651186
34EPHA40.90599050
35DYRK1B0.85970223
36OXSR10.83681921
37MAP4K10.83079334
38BMPR1B0.80749336
39CASK0.80464765
40AKT30.79589673
41PRKG10.79421587
42FGFR20.78535217
43CAMKK20.75956021
44SGK4940.73166581
45SGK2230.73166581
46PRKG20.72739714
47PRKCG0.71964919
48MAP3K20.71277084
49JAK30.70649830
50MAP3K40.68033108
51PRKCQ0.67106644
52MAP3K130.63708333
53CDK190.61470724
54ITK0.60381107
55CAMK1D0.60120888
56MAPK130.58923516
57NUAK10.58624413
58PRKAA20.58599778
59MAP3K110.58522429
60SGK10.58050310
61CAMK40.57744353
62FES0.57502582
63MARK10.57440036
64CAMKK10.56616086
65SGK20.55899379
66TYRO30.55802054
67CDK70.55498075
68PRKCH0.54276149
69NTRK20.52932124
70SYK0.52171397
71WNK40.51118198
72PRKCE0.50214166
73NLK0.47770784
74STK390.47716401
75RPS6KA20.47537614
76MAP2K60.46995960
77PRKCZ0.45706781
78MST1R0.45587572
79MAP2K20.44661285
80RPS6KA10.44473556
81IKBKB0.43206402
82PRKCB0.42149349
83CAMK2A0.40046956
84STK110.40032488
85MARK20.39519668
86GRK60.38334348
87ROCK10.37935088
88JAK20.36926516
89MAPK110.36840161
90TNIK0.36567473
91MARK30.36506256
92PAK30.36461256
93FGFR30.36173246
94GSK3B0.36068310
95CDK50.34584117
96MAPK80.34121456
97TEC0.33452776
98BMPR20.33113873
99FER0.32831956
100MAPK10.32733815

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.78360516
2Fatty acid biosynthesis_Homo sapiens_hsa000613.75916807
3Olfactory transduction_Homo sapiens_hsa047403.36718093
4Nicotine addiction_Homo sapiens_hsa050332.38205206
5Synaptic vesicle cycle_Homo sapiens_hsa047212.12814415
6Butanoate metabolism_Homo sapiens_hsa006502.10236722
7Taste transduction_Homo sapiens_hsa047422.08953466
8Morphine addiction_Homo sapiens_hsa050322.05903734
9Dorso-ventral axis formation_Homo sapiens_hsa043201.90424620
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.90312251
11Type I diabetes mellitus_Homo sapiens_hsa049401.90191457
12Circadian entrainment_Homo sapiens_hsa047131.86433609
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.85964324
14Allograft rejection_Homo sapiens_hsa053301.75800689
15Salivary secretion_Homo sapiens_hsa049701.72945185
16Autoimmune thyroid disease_Homo sapiens_hsa053201.71370158
17Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.66269317
18Graft-versus-host disease_Homo sapiens_hsa053321.62943546
19Phototransduction_Homo sapiens_hsa047441.60934047
20Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55317172
21Insulin secretion_Homo sapiens_hsa049111.55026430
22Glutamatergic synapse_Homo sapiens_hsa047241.53541243
23Type II diabetes mellitus_Homo sapiens_hsa049301.49811009
24GABAergic synapse_Homo sapiens_hsa047271.47796299
25Calcium signaling pathway_Homo sapiens_hsa040201.47031378
26Gastric acid secretion_Homo sapiens_hsa049711.31145603
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28253308
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.27960931
29Amphetamine addiction_Homo sapiens_hsa050311.25710303
30cAMP signaling pathway_Homo sapiens_hsa040241.25286659
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.24052936
32Long-term potentiation_Homo sapiens_hsa047201.23661330
33ABC transporters_Homo sapiens_hsa020101.18287753
34Inositol phosphate metabolism_Homo sapiens_hsa005621.13920375
35Cholinergic synapse_Homo sapiens_hsa047251.12654769
36Renin secretion_Homo sapiens_hsa049241.09699540
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04646807
38Maturity onset diabetes of the young_Homo sapiens_hsa049500.98888781
39Nitrogen metabolism_Homo sapiens_hsa009100.96423270
40Serotonergic synapse_Homo sapiens_hsa047260.96073915
41Oxytocin signaling pathway_Homo sapiens_hsa049210.94268678
42Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.92000153
43Antigen processing and presentation_Homo sapiens_hsa046120.91359412
44Linoleic acid metabolism_Homo sapiens_hsa005910.90848093
45Selenocompound metabolism_Homo sapiens_hsa004500.90055765
46Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89237198
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.87203361
48T cell receptor signaling pathway_Homo sapiens_hsa046600.83867729
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.82334574
50Pancreatic secretion_Homo sapiens_hsa049720.81858145
51Glycerolipid metabolism_Homo sapiens_hsa005610.80953958
52Endocytosis_Homo sapiens_hsa041440.75401350
53Primary immunodeficiency_Homo sapiens_hsa053400.74891845
54Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74164525
55Long-term depression_Homo sapiens_hsa047300.73570322
56Dopaminergic synapse_Homo sapiens_hsa047280.73408893
57Cocaine addiction_Homo sapiens_hsa050300.70029283
58Fatty acid degradation_Homo sapiens_hsa000710.69643944
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69310145
60Oocyte meiosis_Homo sapiens_hsa041140.67342201
61MAPK signaling pathway_Homo sapiens_hsa040100.65051815
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.64767061
63Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63514818
64Intestinal immune network for IgA production_Homo sapiens_hsa046720.62837396
65Estrogen signaling pathway_Homo sapiens_hsa049150.62744701
66Viral myocarditis_Homo sapiens_hsa054160.62298467
67Jak-STAT signaling pathway_Homo sapiens_hsa046300.60714963
68Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58657449
69alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57392732
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57262439
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56946895
72Protein digestion and absorption_Homo sapiens_hsa049740.55790267
73Fatty acid metabolism_Homo sapiens_hsa012120.55785541
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55103316
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49833956
76Bile secretion_Homo sapiens_hsa049760.48753174
77Circadian rhythm_Homo sapiens_hsa047100.48743574
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46871630
79Cardiac muscle contraction_Homo sapiens_hsa042600.46096424
80Choline metabolism in cancer_Homo sapiens_hsa052310.45494650
81B cell receptor signaling pathway_Homo sapiens_hsa046620.45356461
82VEGF signaling pathway_Homo sapiens_hsa043700.44430034
83Chemokine signaling pathway_Homo sapiens_hsa040620.43973541
84Renin-angiotensin system_Homo sapiens_hsa046140.40809343
85Phospholipase D signaling pathway_Homo sapiens_hsa040720.40483205
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.39521702
87Regulation of autophagy_Homo sapiens_hsa041400.38825825
88Arginine and proline metabolism_Homo sapiens_hsa003300.37109623
89Platelet activation_Homo sapiens_hsa046110.35438010
90Sphingolipid signaling pathway_Homo sapiens_hsa040710.34295023
91Influenza A_Homo sapiens_hsa051640.33877551
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33550370
93Retinol metabolism_Homo sapiens_hsa008300.32569291
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.31685828
95Ether lipid metabolism_Homo sapiens_hsa005650.30947008
96mTOR signaling pathway_Homo sapiens_hsa041500.30628739
97Acute myeloid leukemia_Homo sapiens_hsa052210.29913205
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28540866
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.28358879
100Phenylalanine metabolism_Homo sapiens_hsa003600.27690632

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