ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	sperm motility (GO:0030317)	6.89763287
2	acrosome reaction (GO:0007340)	6.63045492
3	response to pheromone (GO:0019236)	6.37241687
4	fusion of sperm to egg plasma membrane (GO:0007342)	5.89138374
5	calcium ion-dependent exocytosis (GO:0017156)	5.09188691
6	protein polyglutamylation (GO:0018095)	5.05241531
7	multicellular organism reproduction (GO:0032504)	4.80727946
8	plasma membrane fusion (GO:0045026)	4.67887461
9	spermatid development (GO:0007286)	4.66659155
10	establishment of protein localization to Golgi (GO:0072600)	4.66021447
11	sperm capacitation (GO:0048240)	4.47737207
12	protein targeting to Golgi (GO:0000042)	4.44423800
13	cellular ketone body metabolic process (GO:0046950)	4.39090087
14	cilium or flagellum-dependent cell motility (GO:0001539)	4.15501095
15	single strand break repair (GO:0000012)	4.11686550
16	regulation of cilium movement (GO:0003352)	4.09174635
17	retrograde transport, vesicle recycling within Golgi (GO:0000301)	4.06102696
18	ketone body metabolic process (GO:1902224)	3.96743656
19	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.95483601
20	sperm-egg recognition (GO:0035036)	3.85090207
21	phosphatidylethanolamine metabolic process (GO:0046337)	3.84567631
22	synaptic vesicle maturation (GO:0016188)	3.83837267
23	reproduction (GO:0000003)	3.78606483
24	epithelial cilium movement (GO:0003351)	3.72796575
25	membrane depolarization during action potential (GO:0086010)	3.68993294
26	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.65026468
27	microtubule polymerization or depolymerization (GO:0031109)	3.64822948
28	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.63651551
29	centriole replication (GO:0007099)	3.53742785
30	axonemal dynein complex assembly (GO:0070286)	3.47476091
31	microtubule depolymerization (GO:0007019)	3.41790303
32	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.41649498
33	protein localization to Golgi apparatus (GO:0034067)	3.40870276
34	gamma-aminobutyric acid transport (GO:0015812)	3.36750934
35	regulation of Rab GTPase activity (GO:0032313)	3.35475334
36	positive regulation of Rab GTPase activity (GO:0032851)	3.35475334
37	behavioral response to nicotine (GO:0035095)	3.32585593
38	cell-cell recognition (GO:0009988)	3.29681700
39	primary amino compound metabolic process (GO:1901160)	3.28493545
40	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.26995658
41	spermatogenesis (GO:0007283)	3.26735788
42	male gamete generation (GO:0048232)	3.26083261
43	synaptic vesicle docking involved in exocytosis (GO:0016081)	3.25052447
44	cilium movement (GO:0003341)	3.23605230
45	glutamate secretion (GO:0014047)	3.22890451
46	rRNA methylation (GO:0031167)	3.22833178
47	alanine transport (GO:0032328)	3.21260640
48	spermatid nucleus differentiation (GO:0007289)	3.18146482
49	neuronal action potential propagation (GO:0019227)	3.15807427
50	piRNA metabolic process (GO:0034587)	3.15330595
51	synaptic vesicle exocytosis (GO:0016079)	3.14332745
52	microtubule severing (GO:0051013)	3.13557416
53	DNA methylation involved in gamete generation (GO:0043046)	3.13429006
54	C4-dicarboxylate transport (GO:0015740)	3.13293436
55	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.13285012
56	proline transport (GO:0015824)	3.12870010
57	organic cation transport (GO:0015695)	3.11850154
58	axoneme assembly (GO:0035082)	3.09404553
59	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.08915839
60	regulation of microtubule-based movement (GO:0060632)	3.06966219
61	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.06684533
62	coenzyme catabolic process (GO:0009109)	3.05536071
63	transmission of nerve impulse (GO:0019226)	3.03684187
64	glutamate receptor signaling pathway (GO:0007215)	3.02103285
65	detection of light stimulus involved in sensory perception (GO:0050962)	3.00621104
66	detection of light stimulus involved in visual perception (GO:0050908)	3.00621104
67	gamete generation (GO:0007276)	2.99847688
68	seminiferous tubule development (GO:0072520)	2.96809265
69	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.96539212
70	synaptic transmission, glutamatergic (GO:0035249)	2.95812172
71	single fertilization (GO:0007338)	2.95182990
72	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.94937320
73	regulation of synaptic vesicle exocytosis (GO:2000300)	2.88586685
74	neuronal action potential (GO:0019228)	2.88394314
75	male meiosis (GO:0007140)	2.88317992
76	regulation of synaptic vesicle transport (GO:1902803)	2.87852574
77	locomotory exploration behavior (GO:0035641)	2.86730334
78	negative regulation of inclusion body assembly (GO:0090084)	2.86697718
79	centriole assembly (GO:0098534)	2.86335469
80	motile cilium assembly (GO:0044458)	2.85432128
81	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.84149079
82	neuromuscular synaptic transmission (GO:0007274)	2.82856458
83	serotonin metabolic process (GO:0042428)	2.82740911
84	regulation of transcription involved in cell fate commitment (GO:0060850)	2.82496723
85	neuron-neuron synaptic transmission (GO:0007270)	2.79284565
86	Golgi to endosome transport (GO:0006895)	2.78779344
87	NAD biosynthetic process (GO:0009435)	2.77537981
88	binding of sperm to zona pellucida (GO:0007339)	2.76335349
89	neurotransmitter secretion (GO:0007269)	2.69247507
90	RNA destabilization (GO:0050779)	2.69003152
91	germ cell development (GO:0007281)	2.67655228
92	protein localization to synapse (GO:0035418)	2.65890208
93	membrane depolarization (GO:0051899)	2.65643844
94	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.62607942
95	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.61147402
96	rRNA modification (GO:0000154)	2.60666210
97	positive regulation of guanylate cyclase activity (GO:0031284)	2.60568316
98	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	2.59708673
99	potassium ion transmembrane transport (GO:0071805)	2.57864115
100	cellular potassium ion transport (GO:0071804)	2.57864115

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.78727998
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.04056397
3	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.50726314
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.41775702
5	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20030354
6	VDR_22108803_ChIP-Seq_LS180_Human	2.15579359
7	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09953696
8	REST_21632747_ChIP-Seq_MESCs_Mouse	2.01483490
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.00355157
10	FUS_26573619_Chip-Seq_HEK293_Human	1.92481771
11	TAF15_26573619_Chip-Seq_HEK293_Human	1.90405652
12	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.89020913
13	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.89020913
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.88471380
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.88270665
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.86127047
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.85568355
18	P300_19829295_ChIP-Seq_ESCs_Human	1.84909936
19	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84198375
20	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.81630548
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.80617328
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.80430313
23	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.80430313
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.72541441
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.72280616
26	SMAD4_21799915_ChIP-Seq_A2780_Human	1.65026885
27	AR_21572438_ChIP-Seq_LNCaP_Human	1.64756626
28	STAT3_23295773_ChIP-Seq_U87_Human	1.59929212
29	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58496402
30	AR_25329375_ChIP-Seq_VCAP_Human	1.57782212
31	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.57311162
32	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.56598897
33	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.52235185
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48466443
35	TCF4_23295773_ChIP-Seq_U87_Human	1.46376433
36	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46149710
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45915993
38	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45533913
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.44120696
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42808497
41	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.41104911
42	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37108954
43	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.36538970
44	* SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36462926
45	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.34559924
46	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.33836218
47	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.33479017
48	RUNX2_22187159_ChIP-Seq_PCA_Human	1.33226926
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.32596230
50	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.31787289
51	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.31223334
52	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.30250630
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29739498
54	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29739498
55	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.28163355
56	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.26384835
57	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.23228040
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.23196164
59	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.23013140
60	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22028172
61	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.20587453
62	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.20547195
63	MYC_19829295_ChIP-Seq_ESCs_Human	1.19708517
64	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.18313083
65	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.17176975
66	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16823390
67	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.16674152
68	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.16282327
69	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.15776091
70	TCF4_22108803_ChIP-Seq_LS180_Human	1.15352176
71	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.15004014
72	ERA_21632823_ChIP-Seq_H3396_Human	1.14599156
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.14338274
74	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.14275598
75	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.13708663
76	OCT4_20526341_ChIP-Seq_ESCs_Human	1.13352822
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.11649911
78	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10433902
79	RNF2_27304074_Chip-Seq_NSC_Mouse	1.09753245
80	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.09246612
81	NCOR_22424771_ChIP-Seq_293T_Human	1.08622123
82	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.08621573
83	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.08367157
84	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07825186
85	TBL1_22424771_ChIP-Seq_293T_Human	1.04659613
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.04040798
87	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.03737225
88	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.03737225
89	TAF2_19829295_ChIP-Seq_ESCs_Human	1.03258456
90	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.02832141
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02727600
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.02501777
93	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01996469
94	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.01728385
95	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.00344239
96	KDM2B_26808549_Chip-Seq_REH_Human	1.00128738
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.99596721
98	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.98743343
99	TP53_22573176_ChIP-Seq_HFKS_Human	0.98729999
100	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98441006

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	5.29439409
2	MP0003880_abnormal_central_pattern	3.48379290
3	MP0004859_abnormal_synaptic_plasticity	3.15238639
4	MP0001968_abnormal_touch/_nociception	2.86771136
5	MP0009046_muscle_twitch	2.83897488
6	MP0009745_abnormal_behavioral_response	2.77174757
7	MP0001486_abnormal_startle_reflex	2.60110652
8	MP0008877_abnormal_DNA_methylation	2.59207248
9	MP0001501_abnormal_sleep_pattern	2.53398051
10	MP0002272_abnormal_nervous_system	2.51209598
11	MP0003635_abnormal_synaptic_transmissio	2.49563905
12	MP0005377_hearing/vestibular/ear_phenot	2.48135209
13	MP0003878_abnormal_ear_physiology	2.48135209
14	MP0002064_seizures	2.44679769
15	MP0005423_abnormal_somatic_nervous	2.42526801
16	MP0003698_abnormal_male_reproductive	2.28038985
17	MP0005551_abnormal_eye_electrophysiolog	2.15072099
18	MP0004270_analgesia	2.13663299
19	MP0002572_abnormal_emotion/affect_behav	2.08978869
20	MP0002063_abnormal_learning/memory/cond	1.97977529
21	MP0001485_abnormal_pinna_reflex	1.95486635
22	MP0002735_abnormal_chemical_nociception	1.90327224
23	MP0005646_abnormal_pituitary_gland	1.88269391
24	MP0003787_abnormal_imprinting	1.86334335
25	MP0001929_abnormal_gametogenesis	1.85641100
26	MP0002736_abnormal_nociception_after	1.83383605
27	MP0002734_abnormal_mechanical_nocicepti	1.71413420
28	MP0003879_abnormal_hair_cell	1.67031942
29	MP0006276_abnormal_autonomic_nervous	1.64053747
30	MP0003646_muscle_fatigue	1.63826136
31	MP0002067_abnormal_sensory_capabilities	1.62613598
32	MP0001970_abnormal_pain_threshold	1.60303997
33	MP0001984_abnormal_olfaction	1.60185182
34	MP0002557_abnormal_social/conspecific_i	1.60175653
35	MP0002733_abnormal_thermal_nociception	1.57484759
36	MP0005670_abnormal_white_adipose	1.54531841
37	MP0004885_abnormal_endolymph	1.51151116
38	MP0003195_calcinosis	1.50709605
39	MP0004742_abnormal_vestibular_system	1.46986718
40	MP0001905_abnormal_dopamine_level	1.39181612
41	MP0010386_abnormal_urinary_bladder	1.37921933
42	MP0008569_lethality_at_weaning	1.36961025
43	MP0008872_abnormal_physiological_respon	1.36540124
44	MP0002229_neurodegeneration	1.36325561
45	MP0000569_abnormal_digit_pigmentation	1.35552575
46	MP0005253_abnormal_eye_physiology	1.34309647
47	MP0002837_dystrophic_cardiac_calcinosis	1.34188389
48	MP0005645_abnormal_hypothalamus_physiol	1.30897782
49	MP0001440_abnormal_grooming_behavior	1.30029818
50	MP0003633_abnormal_nervous_system	1.26185159
51	MP0001986_abnormal_taste_sensitivity	1.24839244
52	MP0008995_early_reproductive_senescence	1.24690993
53	MP0001963_abnormal_hearing_physiology	1.23549200
54	MP0005386_behavior/neurological_phenoty	1.23160850
55	MP0004924_abnormal_behavior	1.23160850
56	MP0005379_endocrine/exocrine_gland_phen	1.19604104
57	MP0004142_abnormal_muscle_tone	1.19070070
58	MP0002822_catalepsy	1.18978665
59	MP0002638_abnormal_pupillary_reflex	1.18799549
60	MP0002161_abnormal_fertility/fecundity	1.13271023
61	MP0001348_abnormal_lacrimal_gland	1.09345466
62	MP0005167_abnormal_blood-brain_barrier	1.06467214
63	MP0003631_nervous_system_phenotype	1.03940391
64	MP0002210_abnormal_sex_determination	1.02938206
65	MP0002160_abnormal_reproductive_system	1.02320542
66	MP0001765_abnormal_ion_homeostasis	1.00523292
67	MP0006072_abnormal_retinal_apoptosis	1.00340571
68	MP0002102_abnormal_ear_morphology	0.98443307
69	MP0000955_abnormal_spinal_cord	0.96396424
70	MP0002882_abnormal_neuron_morphology	0.95874534
71	MP0008875_abnormal_xenobiotic_pharmacok	0.93898492
72	MP0002876_abnormal_thyroid_physiology	0.93673513
73	MP0003718_maternal_effect	0.92574035
74	MP0000631_abnormal_neuroendocrine_gland	0.91848282
75	MP0004085_abnormal_heartbeat	0.90017747
76	MP0000653_abnormal_sex_gland	0.89528988
77	MP0005310_abnormal_salivary_gland	0.87395448
78	MP0001145_abnormal_male_reproductive	0.87170775
79	MP0004811_abnormal_neuron_physiology	0.85704324
80	MP0002066_abnormal_motor_capabilities/c	0.85362335
81	MP0005535_abnormal_body_temperature	0.84397542
82	MP0001502_abnormal_circadian_rhythm	0.84312789
83	MP0000427_abnormal_hair_cycle	0.83698636
84	MP0002184_abnormal_innervation	0.82623464
85	MP0005389_reproductive_system_phenotype	0.82557378
86	MP0001529_abnormal_vocalization	0.82357905
87	MP0000026_abnormal_inner_ear	0.79626802
88	MP0009780_abnormal_chondrocyte_physiolo	0.79446971
89	MP0004484_altered_response_of	0.78996971
90	MP0003011_delayed_dark_adaptation	0.78996033
91	MP0003137_abnormal_impulse_conducting	0.78837175
92	MP0002138_abnormal_hepatobiliary_system	0.69765868
93	MP0002752_abnormal_somatic_nervous	0.69581639
94	MP0004043_abnormal_pH_regulation	0.69509613
95	MP0003632_abnormal_nervous_system	0.69211803
96	MP0003045_fibrosis	0.67495029
97	MP0004215_abnormal_myocardial_fiber	0.67112476
98	MP0002693_abnormal_pancreas_physiology	0.66928510
99	MP0002909_abnormal_adrenal_gland	0.64936945
100	MP0000230_abnormal_systemic_arterial	0.64890746

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Progressive cerebellar ataxia (HP:0002073)	4.28586757
2	Severe visual impairment (HP:0001141)	4.25842133
3	Attenuation of retinal blood vessels (HP:0007843)	4.21663794
4	Febrile seizures (HP:0002373)	4.02386704
5	Focal motor seizures (HP:0011153)	3.93894555
6	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.92639794
7	Absent/shortened dynein arms (HP:0200106)	3.92639794
8	Atonic seizures (HP:0010819)	3.80387726
9	Chronic hepatic failure (HP:0100626)	3.78307775
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.76440334
11	Bony spicule pigmentary retinopathy (HP:0007737)	3.69340353
12	Myokymia (HP:0002411)	3.51728191
13	Focal seizures (HP:0007359)	3.48730897
14	Nephronophthisis (HP:0000090)	3.38596469
15	Pancreatic cysts (HP:0001737)	3.30817818
16	Abnormality of macular pigmentation (HP:0008002)	3.24305722
17	Gaze-evoked nystagmus (HP:0000640)	3.17845937
18	True hermaphroditism (HP:0010459)	3.13943912
19	Pancreatic fibrosis (HP:0100732)	3.13892373
20	Abnormal ciliary motility (HP:0012262)	3.12395149
21	Abnormal drinking behavior (HP:0030082)	3.09122747
22	Polydipsia (HP:0001959)	3.09122747
23	Postural instability (HP:0002172)	3.00064386
24	Decreased central vision (HP:0007663)	2.94893773
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.91628155
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.91628155
27	Abnormality of the renal medulla (HP:0100957)	2.91606934
28	Congenital stationary night blindness (HP:0007642)	2.85648158
29	Molar tooth sign on MRI (HP:0002419)	2.83731163
30	Abnormality of midbrain morphology (HP:0002418)	2.83731163
31	Genetic anticipation (HP:0003743)	2.82929142
32	Epileptic encephalopathy (HP:0200134)	2.79974243
33	Dialeptic seizures (HP:0011146)	2.78475685
34	Abnormal respiratory motile cilium physiology (HP:0012261)	2.78381875
35	Absence seizures (HP:0002121)	2.59620169
36	Hyperventilation (HP:0002883)	2.58766794
37	Abnormality of the renal cortex (HP:0011035)	2.52383125
38	Type II lissencephaly (HP:0007260)	2.49438058
39	Tubulointerstitial nephritis (HP:0001970)	2.48696645
40	Polyuria (HP:0000103)	2.47374890
41	Medial flaring of the eyebrow (HP:0010747)	2.37345461
42	Abnormal urine output (HP:0012590)	2.36460821
43	Cystic liver disease (HP:0006706)	2.36048256
44	Congenital sensorineural hearing impairment (HP:0008527)	2.29789355
45	Hemiparesis (HP:0001269)	2.29317110
46	Facial shape deformation (HP:0011334)	2.27446418
47	Potter facies (HP:0002009)	2.27446418
48	Hyperkalemia (HP:0002153)	2.25402526
49	Papilledema (HP:0001085)	2.24141342
50	Male pseudohermaphroditism (HP:0000037)	2.21391702
51	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.20806556
52	Inability to walk (HP:0002540)	2.16094534
53	Abnormality of binocular vision (HP:0011514)	2.15074444
54	Diplopia (HP:0000651)	2.15074444
55	Gait imbalance (HP:0002141)	2.14523446
56	Abnormality of renal excretion (HP:0011036)	2.11679083
57	Infertility (HP:0000789)	2.11401037
58	Tubular atrophy (HP:0000092)	2.11007981
59	Absent speech (HP:0001344)	2.07755006
60	Optic nerve hypoplasia (HP:0000609)	2.07441728
61	Hypoplastic ischia (HP:0003175)	2.05692840
62	Amelogenesis imperfecta (HP:0000705)	2.02012435
63	Amblyopia (HP:0000646)	2.01755953
64	Action tremor (HP:0002345)	2.01254439
65	Pendular nystagmus (HP:0012043)	1.99407455
66	Resting tremor (HP:0002322)	1.97555448
67	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.95870214
68	Limb dystonia (HP:0002451)	1.94234731
69	Cerebellar dysplasia (HP:0007033)	1.91330405
70	Congenital primary aphakia (HP:0007707)	1.89932639
71	Abolished electroretinogram (ERG) (HP:0000550)	1.86998786
72	Decreased circulating renin level (HP:0003351)	1.86145222
73	Occipital encephalocele (HP:0002085)	1.85130171
74	Genital tract atresia (HP:0001827)	1.84652708
75	Intestinal atresia (HP:0011100)	1.84618217
76	Male infertility (HP:0003251)	1.84050372
77	Hemiplegia (HP:0002301)	1.83522250
78	Abnormality of dental color (HP:0011073)	1.83309528
79	Retinal dysplasia (HP:0007973)	1.83096601
80	Generalized tonic-clonic seizures (HP:0002069)	1.79543409
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.79053965
82	Broad-based gait (HP:0002136)	1.78289959
83	Sclerocornea (HP:0000647)	1.78020656
84	Abnormality of potassium homeostasis (HP:0011042)	1.77423029
85	Vaginal atresia (HP:0000148)	1.76269696
86	Rhinitis (HP:0012384)	1.75871380
87	Gonadal dysgenesis (HP:0000133)	1.75812953
88	Nephrogenic diabetes insipidus (HP:0009806)	1.74579007
89	Photophobia (HP:0000613)	1.74046094
90	Tubulointerstitial abnormality (HP:0001969)	1.73673599
91	Poor coordination (HP:0002370)	1.70988608
92	Protruding tongue (HP:0010808)	1.70955439
93	Abnormality of the ischium (HP:0003174)	1.70548972
94	Congenital hepatic fibrosis (HP:0002612)	1.70266144
95	Epileptiform EEG discharges (HP:0011182)	1.69709058
96	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	1.69016352
97	Macular degeneration (HP:0000608)	1.66362044
98	Status epilepticus (HP:0002133)	1.65809919
99	Aplasia/Hypoplasia of the earlobes (HP:0009906)	1.63680804
100	Type II diabetes mellitus (HP:0005978)	1.62666074

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.31970997
2	PLK4	3.37043150
3	MAP4K2	3.11511301
4	PLK2	2.92076324
5	PINK1	2.89040197
6	NTRK3	2.70121452
7	INSRR	2.67832762
8	EPHA4	2.40507818
9	DAPK2	2.22256961
10	STK38	2.10571999
11	OXSR1	1.79055768
12	MAPK13	1.69138469
13	ADRBK2	1.67905799
14	MARK1	1.61847486
15	STK38L	1.60521017
16	PRKD3	1.59884076
17	BMPR1B	1.58328774
18	CASK	1.56964365
19	TAOK3	1.50278641
20	WNK3	1.40978048
21	MAP3K4	1.40000769
22	GRK1	1.35937712
23	ACVR1B	1.28176379
24	PTK2B	1.26993742
25	WNK4	1.25951038
26	CAMKK2	1.25194640
27	PRKCG	1.22830069
28	NUAK1	1.20154142
29	CAMK1	1.19160116
30	STK39	1.17716734
31	PAK3	1.17690870
32	PNCK	1.17485731
33	DDR2	1.15363499
34	TESK1	1.13957738
35	UHMK1	1.13618440
36	FGFR2	1.12381165
37	MAP3K9	1.07828119
38	PAK6	1.06193741
39	TNK2	1.01638954
40	CAMK1G	1.00875132
41	SGK494	0.99794609
42	SGK223	0.99794609
43	MINK1	0.99318163
44	GRK5	0.98669800
45	PDK1	0.98358785
46	NTRK2	0.98072090
47	AKT3	0.96461850
48	ZAK	0.96430928
49	TXK	0.95013417
50	MAP2K6	0.93481724
51	SGK2	0.91780235
52	SIK2	0.91588650
53	CAMKK1	0.91419080
54	PRKCE	0.89522092
55	MAP2K7	0.85302219
56	MAPK15	0.81899275
57	NEK6	0.81705703
58	CDK19	0.81143425
59	STK11	0.80035799
60	TNIK	0.79672422
61	PIK3CG	0.78048917
62	WNK1	0.76538406
63	PHKG1	0.75423751
64	PHKG2	0.75423751
65	CAMK2A	0.73216782
66	CDK5	0.72002429
67	TLK1	0.70937694
68	BRD4	0.70496752
69	PDPK1	0.69525203
70	MARK3	0.65960057
71	SGK1	0.64676151
72	PRKCH	0.64360087
73	PRKCQ	0.62167408
74	PRKG1	0.62060676
75	CAMK4	0.59251670
76	PKN1	0.57813324
77	ADRBK1	0.50564203
78	CSNK1G2	0.49852099
79	DYRK1A	0.49842365
80	TYRO3	0.49612227
81	PRKAA2	0.48881768
82	MUSK	0.45449139
83	PRKCZ	0.45345008
84	PRKG2	0.45285886
85	RIPK4	0.45224593
86	PRKACA	0.42077077
87	NLK	0.39613621
88	CAMK1D	0.38862367
89	PRKCA	0.38412036
90	PRKCB	0.38153490
91	RPS6KA3	0.36747891
92	TRIM28	0.35180179
93	CSNK1A1	0.35118450
94	DYRK2	0.34969025
95	MAP3K2	0.33986706
96	ITK	0.33911730
97	CSNK1D	0.32598982
98	SGK3	0.32270273
99	CDK3	0.31594818
100	CAMK2B	0.29981576

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.79964109
2	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.27923396
3	Olfactory transduction_Homo sapiens_hsa04740	2.87219790
4	Phototransduction_Homo sapiens_hsa04744	2.53506029
5	Morphine addiction_Homo sapiens_hsa05032	2.52063791
6	Butanoate metabolism_Homo sapiens_hsa00650	2.50872237
7	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.40566180
8	Circadian entrainment_Homo sapiens_hsa04713	2.35130943
9	GABAergic synapse_Homo sapiens_hsa04727	2.25431336
10	Taste transduction_Homo sapiens_hsa04742	2.22406742
11	Glutamatergic synapse_Homo sapiens_hsa04724	2.18280465
12	Insulin secretion_Homo sapiens_hsa04911	2.14685232
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.11378178
14	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.97882879
15	Salivary secretion_Homo sapiens_hsa04970	1.87136301
16	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.84122586
17	Amphetamine addiction_Homo sapiens_hsa05031	1.71374747
18	Nitrogen metabolism_Homo sapiens_hsa00910	1.70461715
19	Calcium signaling pathway_Homo sapiens_hsa04020	1.63220137
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62848947
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.62025536
22	Gastric acid secretion_Homo sapiens_hsa04971	1.48389084
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.42043353
24	Serotonergic synapse_Homo sapiens_hsa04726	1.41567327
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.39640271
26	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.38259127
27	Dopaminergic synapse_Homo sapiens_hsa04728	1.35355116
28	ABC transporters_Homo sapiens_hsa02010	1.28097689
29	cAMP signaling pathway_Homo sapiens_hsa04024	1.24329433
30	Cholinergic synapse_Homo sapiens_hsa04725	1.22807810
31	Long-term potentiation_Homo sapiens_hsa04720	1.22655501
32	Renin secretion_Homo sapiens_hsa04924	1.21545797
33	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.20912400
34	Cocaine addiction_Homo sapiens_hsa05030	1.18771426
35	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.15119330
36	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.11024719
37	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.09382076
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.09090554
39	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.07737970
40	Cardiac muscle contraction_Homo sapiens_hsa04260	1.06128729
41	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.03028831
42	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.00786095
43	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00687920
44	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.00069119
45	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.99374147
46	Long-term depression_Homo sapiens_hsa04730	0.98809232
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.96820878
48	Type II diabetes mellitus_Homo sapiens_hsa04930	0.91895169
49	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.91146961
50	Circadian rhythm_Homo sapiens_hsa04710	0.89780977
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87892702
52	Pancreatic secretion_Homo sapiens_hsa04972	0.85816978
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.85532936
54	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.84970676
55	Caffeine metabolism_Homo sapiens_hsa00232	0.84646385
56	Propanoate metabolism_Homo sapiens_hsa00640	0.83437143
57	Collecting duct acid secretion_Homo sapiens_hsa04966	0.81972047
58	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79050571
59	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.78162286
60	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.76997061
61	beta-Alanine metabolism_Homo sapiens_hsa00410	0.76199376
62	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76158465
63	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.75736666
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74742160
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.74546458
66	Regulation of autophagy_Homo sapiens_hsa04140	0.74460796
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.73228989
68	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.73184858
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73072557
70	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.72996288
71	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71336003
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.68699836
73	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.64765757
74	Histidine metabolism_Homo sapiens_hsa00340	0.64230032
75	Oocyte meiosis_Homo sapiens_hsa04114	0.62389311
76	Basal transcription factors_Homo sapiens_hsa03022	0.59528464
77	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.59063334
78	Mineral absorption_Homo sapiens_hsa04978	0.57216987
79	Oxidative phosphorylation_Homo sapiens_hsa00190	0.54717988
80	Retinol metabolism_Homo sapiens_hsa00830	0.54052928
81	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.53788510
82	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53355294
83	Fatty acid degradation_Homo sapiens_hsa00071	0.52179481
84	Peroxisome_Homo sapiens_hsa04146	0.52094977
85	Bile secretion_Homo sapiens_hsa04976	0.51920790
86	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.48087222
87	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.46276339
88	MAPK signaling pathway_Homo sapiens_hsa04010	0.43078610
89	Fatty acid metabolism_Homo sapiens_hsa01212	0.39590317
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39095142
91	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.37997920
92	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.37458625
93	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.36834295
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.35915353
95	Sphingolipid metabolism_Homo sapiens_hsa00600	0.35311750
96	Huntingtons disease_Homo sapiens_hsa05016	0.35030896
97	Fat digestion and absorption_Homo sapiens_hsa04975	0.32521092
98	Estrogen signaling pathway_Homo sapiens_hsa04915	0.30707747
99	Gap junction_Homo sapiens_hsa04540	0.30399266
100	Purine metabolism_Homo sapiens_hsa00230	0.30379238

FAM153B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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