ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	5.29241118
2	sperm motility (GO:0030317)	4.80116137
3	cellular ketone body metabolic process (GO:0046950)	4.66922584
4	behavioral response to nicotine (GO:0035095)	4.55444988
5	protein polyglutamylation (GO:0018095)	4.39647911
6	acrosome reaction (GO:0007340)	4.34303703
7	detection of light stimulus involved in sensory perception (GO:0050962)	4.32248772
8	detection of light stimulus involved in visual perception (GO:0050908)	4.32248772
9	ketone body metabolic process (GO:1902224)	4.14801602
10	multicellular organism reproduction (GO:0032504)	4.14399423
11	fucose catabolic process (GO:0019317)	4.12557788
12	L-fucose metabolic process (GO:0042354)	4.12557788
13	L-fucose catabolic process (GO:0042355)	4.12557788
14	gamma-aminobutyric acid transport (GO:0015812)	4.04808194
15	epithelial cilium movement (GO:0003351)	3.65004512
16	regulation of cilium movement (GO:0003352)	3.62170186
17	piRNA metabolic process (GO:0034587)	3.58566809
18	establishment of protein localization to Golgi (GO:0072600)	3.57835283
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.54596780
20	fusion of sperm to egg plasma membrane (GO:0007342)	3.38035474
21	protein targeting to Golgi (GO:0000042)	3.36056271
22	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.35745916
23	calcium ion-dependent exocytosis (GO:0017156)	3.34401741
24	cilium or flagellum-dependent cell motility (GO:0001539)	3.34223763
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.30798664
26	axoneme assembly (GO:0035082)	3.24340321
27	spermatid development (GO:0007286)	3.17289337
28	indole-containing compound catabolic process (GO:0042436)	3.13833657
29	indolalkylamine catabolic process (GO:0046218)	3.13833657
30	tryptophan catabolic process (GO:0006569)	3.13833657
31	primary amino compound metabolic process (GO:1901160)	3.12523209
32	cilium movement (GO:0003341)	3.06035519
33	DNA methylation involved in gamete generation (GO:0043046)	3.05778450
34	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.05566246
35	neuronal action potential propagation (GO:0019227)	3.04662707
36	indolalkylamine metabolic process (GO:0006586)	3.04488506
37	cAMP catabolic process (GO:0006198)	3.03331168
38	membrane depolarization during action potential (GO:0086010)	3.00797007
39	reproduction (GO:0000003)	3.00577813
40	DNA deamination (GO:0045006)	2.99715898
41	organic cation transport (GO:0015695)	2.99598954
42	neuronal action potential (GO:0019228)	2.96351598
43	C4-dicarboxylate transport (GO:0015740)	2.95682757
44	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.95678772
45	water-soluble vitamin biosynthetic process (GO:0042364)	2.95054253
46	protein localization to Golgi apparatus (GO:0034067)	2.94195511
47	regulation of hexokinase activity (GO:1903299)	2.92636623
48	regulation of glucokinase activity (GO:0033131)	2.92636623
49	regulation of microtubule-based movement (GO:0060632)	2.90470233
50	sperm-egg recognition (GO:0035036)	2.87319109
51	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.87112731
52	cyclic nucleotide catabolic process (GO:0009214)	2.86856986
53	alanine transport (GO:0032328)	2.86150132
54	axonemal dynein complex assembly (GO:0070286)	2.82944770
55	plasma membrane fusion (GO:0045026)	2.79304495
56	retinal cone cell development (GO:0046549)	2.78109418
57	tryptophan metabolic process (GO:0006568)	2.75483184
58	kynurenine metabolic process (GO:0070189)	2.73559311
59	indole-containing compound metabolic process (GO:0042430)	2.72968375
60	spinal cord motor neuron differentiation (GO:0021522)	2.72940336
61	behavioral response to ethanol (GO:0048149)	2.71320272
62	centriole replication (GO:0007099)	2.69622941
63	coenzyme catabolic process (GO:0009109)	2.69249784
64	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.69114603
65	cilium organization (GO:0044782)	2.68097329
66	preassembly of GPI anchor in ER membrane (GO:0016254)	2.66362865
67	regulation of neurotransmitter uptake (GO:0051580)	2.65664307
68	serotonin metabolic process (GO:0042428)	2.62761462
69	phosphatidylethanolamine biosynthetic process (GO:0006646)	2.61679819
70	negative regulation of telomere maintenance (GO:0032205)	2.61340960
71	single strand break repair (GO:0000012)	2.60543426
72	cilium assembly (GO:0042384)	2.60196604
73	positive regulation of meiosis (GO:0045836)	2.60174734
74	reflex (GO:0060004)	2.59880735
75	nephron tubule morphogenesis (GO:0072078)	2.58615900
76	nephron epithelium morphogenesis (GO:0072088)	2.58615900
77	kidney morphogenesis (GO:0060993)	2.58258568
78	NAD biosynthetic process (GO:0009435)	2.57335762
79	phosphatidylethanolamine metabolic process (GO:0046337)	2.57063546
80	photoreceptor cell maintenance (GO:0045494)	2.56909784
81	auditory receptor cell stereocilium organization (GO:0060088)	2.56221162
82	male meiosis (GO:0007140)	2.55729988
83	seminiferous tubule development (GO:0072520)	2.55583171
84	regulation of action potential (GO:0098900)	2.54049475
85	RNA destabilization (GO:0050779)	2.53009936
86	proline transport (GO:0015824)	2.52945252
87	protein localization to cilium (GO:0061512)	2.52842782
88	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.52257156
89	inositol phosphate catabolic process (GO:0071545)	2.48538027
90	protein K11-linked deubiquitination (GO:0035871)	2.47590333
91	somite rostral/caudal axis specification (GO:0032525)	2.47573793
92	cell-cell recognition (GO:0009988)	2.46591871
93	glycerophospholipid catabolic process (GO:0046475)	2.45949151
94	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.43850347
95	nonmotile primary cilium assembly (GO:0035058)	2.42651392
96	positive regulation of meiotic cell cycle (GO:0051446)	2.42626565
97	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.42086354
98	regulation of mesoderm development (GO:2000380)	2.40437274
99	platelet dense granule organization (GO:0060155)	2.40009560
100	cell wall macromolecule metabolic process (GO:0044036)	2.39728259

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.63665614
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.10263427
3	GBX2_23144817_ChIP-Seq_PC3_Human	2.93677599
4	VDR_22108803_ChIP-Seq_LS180_Human	2.65286606
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.64896810
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.43240388
7	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.41797137
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.31275947
9	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.21953243
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.20985534
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14770521
12	FUS_26573619_Chip-Seq_HEK293_Human	2.10323768
13	TAF15_26573619_Chip-Seq_HEK293_Human	2.02530360
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.01460134
15	* P300_19829295_ChIP-Seq_ESCs_Human	1.98007396
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97246119
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.92832573
18	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.72954645
19	REST_21632747_ChIP-Seq_MESCs_Mouse	1.71966622
20	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.70686616
21	CBP_20019798_ChIP-Seq_JUKART_Human	1.70686616
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64820696
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61967922
24	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.61346157
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.58416431
26	AR_25329375_ChIP-Seq_VCAP_Human	1.58416308
27	EWS_26573619_Chip-Seq_HEK293_Human	1.57303074
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.57176269
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.55859311
30	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.55109241
31	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.55109241
32	STAT3_23295773_ChIP-Seq_U87_Human	1.53951061
33	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.52434981
34	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.47512235
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.43994534
36	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.43540436
37	TCF4_23295773_ChIP-Seq_U87_Human	1.42421123
38	BCAT_22108803_ChIP-Seq_LS180_Human	1.42124865
39	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.41785119
40	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.41282403
41	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.40959098
42	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.40402935
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37774596
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37774596
45	TP53_22573176_ChIP-Seq_HFKS_Human	1.36194384
46	AR_21572438_ChIP-Seq_LNCaP_Human	1.35025804
47	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.34952420
48	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.34404421
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34390059
50	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.32726261
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.32726261
52	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.32673188
53	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.32365352
54	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.32344385
55	* GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30101817
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.27601086
57	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.26717524
58	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26425643
59	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26132133
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.26020820
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23999130
62	DROSHA_22980978_ChIP-Seq_HELA_Human	1.23331701
63	TCF4_22108803_ChIP-Seq_LS180_Human	1.22057982
64	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.21952618
65	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21142822
66	RNF2_27304074_Chip-Seq_NSC_Mouse	1.20100523
67	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.19349699
68	IRF1_19129219_ChIP-ChIP_H3396_Human	1.19076375
69	NCOR_22424771_ChIP-Seq_293T_Human	1.17813045
70	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17705584
71	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.16533224
72	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.16171489
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15482183
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.15449647
75	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.15327634
76	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.13964885
77	MYC_19829295_ChIP-Seq_ESCs_Human	1.13713912
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11862597
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11554357
80	ERA_21632823_ChIP-Seq_H3396_Human	1.11541221
81	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10889444
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10457680
83	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07761297
84	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05179569
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.04808248
86	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.04614855
87	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.03826228
88	AR_20517297_ChIP-Seq_VCAP_Human	1.00704939
89	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00694257
90	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.99777406
91	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99710432
92	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99453181
93	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99286569
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99074449
95	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.98778894
96	CDX2_22108803_ChIP-Seq_LS180_Human	0.98391829
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.97998750
98	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97980972
99	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97720307
100	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96618132

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	3.35215466
2	MP0008877_abnormal_DNA_methylation	2.87105315
3	MP0003195_calcinosis	2.80873178
4	MP0001968_abnormal_touch/_nociception	2.74167880
5	MP0005551_abnormal_eye_electrophysiolog	2.47817809
6	MP0009745_abnormal_behavioral_response	2.41299147
7	MP0009046_muscle_twitch	2.35829961
8	MP0003880_abnormal_central_pattern	2.22251708
9	MP0005645_abnormal_hypothalamus_physiol	2.19369378
10	MP0001501_abnormal_sleep_pattern	2.11115183
11	MP0002272_abnormal_nervous_system	2.08733898
12	MP0002837_dystrophic_cardiac_calcinosis	2.08688217
13	MP0003646_muscle_fatigue	2.05034108
14	MP0005646_abnormal_pituitary_gland	2.00870349
15	MP0004885_abnormal_endolymph	2.00605763
16	MP0001486_abnormal_startle_reflex	2.00426480
17	MP0002736_abnormal_nociception_after	1.95599273
18	MP0002102_abnormal_ear_morphology	1.93431566
19	MP0000569_abnormal_digit_pigmentation	1.85416358
20	MP0008872_abnormal_physiological_respon	1.84598352
21	MP0002064_seizures	1.83713274
22	MP0004147_increased_porphyrin_level	1.83157796
23	MP0003787_abnormal_imprinting	1.82771878
24	MP0002735_abnormal_chemical_nociception	1.76728569
25	MP0006072_abnormal_retinal_apoptosis	1.74483686
26	MP0002876_abnormal_thyroid_physiology	1.73331431
27	MP0001986_abnormal_taste_sensitivity	1.72750479
28	MP0005253_abnormal_eye_physiology	1.72125821
29	MP0002572_abnormal_emotion/affect_behav	1.71212938
30	MP0005377_hearing/vestibular/ear_phenot	1.70831637
31	MP0003878_abnormal_ear_physiology	1.70831637
32	MP0003011_delayed_dark_adaptation	1.67298893
33	MP0008875_abnormal_xenobiotic_pharmacok	1.67006436
34	MP0001485_abnormal_pinna_reflex	1.62763641
35	MP0003635_abnormal_synaptic_transmissio	1.61343553
36	MP0003698_abnormal_male_reproductive	1.61290150
37	MP0002557_abnormal_social/conspecific_i	1.57903206
38	MP0004742_abnormal_vestibular_system	1.53103326
39	MP0001984_abnormal_olfaction	1.45157267
40	MP0005379_endocrine/exocrine_gland_phen	1.44917348
41	MP0005423_abnormal_somatic_nervous	1.44033008
42	MP0002138_abnormal_hepatobiliary_system	1.43467323
43	MP0004142_abnormal_muscle_tone	1.42705927
44	MP0001970_abnormal_pain_threshold	1.42135447
45	MP0002067_abnormal_sensory_capabilities	1.39605748
46	MP0002733_abnormal_thermal_nociception	1.38511036
47	MP0002063_abnormal_learning/memory/cond	1.37222675
48	MP0006276_abnormal_autonomic_nervous	1.35468250
49	MP0001929_abnormal_gametogenesis	1.34451684
50	MP0004859_abnormal_synaptic_plasticity	1.32151356
51	MP0004043_abnormal_pH_regulation	1.31145491
52	MP0005084_abnormal_gallbladder_morpholo	1.29958312
53	MP0002638_abnormal_pupillary_reflex	1.29444260
54	MP0002734_abnormal_mechanical_nocicepti	1.28770983
55	MP0001529_abnormal_vocalization	1.27318126
56	MP0001905_abnormal_dopamine_level	1.27297660
57	MP0006292_abnormal_olfactory_placode	1.26982016
58	MP0010386_abnormal_urinary_bladder	1.26527021
59	MP0004924_abnormal_behavior	1.22744584
60	MP0005386_behavior/neurological_phenoty	1.22744584
61	MP0003283_abnormal_digestive_organ	1.22153176
62	MP0003136_yellow_coat_color	1.19823008
63	MP0000427_abnormal_hair_cycle	1.19454383
64	MP0000631_abnormal_neuroendocrine_gland	1.18430892
65	MP0005167_abnormal_blood-brain_barrier	1.16030223
66	MP0002234_abnormal_pharynx_morphology	1.15961599
67	MP0002229_neurodegeneration	1.14297023
68	MP0002653_abnormal_ependyma_morphology	1.05974951
69	MP0001963_abnormal_hearing_physiology	1.05197240
70	MP0002909_abnormal_adrenal_gland	1.04467682
71	MP0005174_abnormal_tail_pigmentation	1.03960527
72	MP0005389_reproductive_system_phenotype	1.03185756
73	MP0003718_maternal_effect	1.00723653
74	MP0000372_irregular_coat_pigmentation	1.00074592
75	MP0002693_abnormal_pancreas_physiology	0.98422006
76	MP0002160_abnormal_reproductive_system	0.98381338
77	MP0002928_abnormal_bile_duct	0.96036763
78	MP0002938_white_spotting	0.94047395
79	MP0004270_analgesia	0.93667391
80	MP0005332_abnormal_amino_acid	0.92866919
81	MP0004133_heterotaxia	0.91799508
82	MP0010329_abnormal_lipoprotein_level	0.91590417
83	MP0001765_abnormal_ion_homeostasis	0.89686322
84	MP0009780_abnormal_chondrocyte_physiolo	0.88954858
85	MP0002822_catalepsy	0.88759324
86	MP0008995_early_reproductive_senescence	0.86533697
87	MP0003137_abnormal_impulse_conducting	0.86396311
88	MP0001440_abnormal_grooming_behavior	0.85949443
89	MP0000230_abnormal_systemic_arterial	0.85648787
90	MP0000026_abnormal_inner_ear	0.85627885
91	MP0004085_abnormal_heartbeat	0.83776816
92	MP0002184_abnormal_innervation	0.83594199
93	MP0005195_abnormal_posterior_eye	0.82732520
94	MP0001944_abnormal_pancreas_morphology	0.81450651
95	MP0001502_abnormal_circadian_rhythm	0.81274541
96	MP0002210_abnormal_sex_determination	0.81063420
97	MP0003633_abnormal_nervous_system	0.79686619
98	MP0004145_abnormal_muscle_electrophysio	0.79095131
99	MP0004215_abnormal_myocardial_fiber	0.79014433
100	MP0008775_abnormal_heart_ventricle	0.78765655

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.46564383
2	Abnormal rod and cone electroretinograms (HP:0008323)	4.04219730
3	Attenuation of retinal blood vessels (HP:0007843)	3.94977165
4	Pancreatic cysts (HP:0001737)	3.89730817
5	Abnormality of midbrain morphology (HP:0002418)	3.69403377
6	Molar tooth sign on MRI (HP:0002419)	3.69403377
7	Pancreatic fibrosis (HP:0100732)	3.65531401
8	Nephronophthisis (HP:0000090)	3.62903643
9	Type II lissencephaly (HP:0007260)	3.56834019
10	Abnormality of the renal cortex (HP:0011035)	3.34524906
11	True hermaphroditism (HP:0010459)	3.34242678
12	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.26633353
13	Absent/shortened dynein arms (HP:0200106)	3.26633353
14	Abnormal drinking behavior (HP:0030082)	3.17960112
15	Polydipsia (HP:0001959)	3.17960112
16	Abnormality of the renal medulla (HP:0100957)	3.16825239
17	Abnormality of macular pigmentation (HP:0008002)	3.16208550
18	Chronic hepatic failure (HP:0100626)	3.16177862
19	Severe visual impairment (HP:0001141)	3.13784909
20	Hyperventilation (HP:0002883)	2.98423913
21	Progressive cerebellar ataxia (HP:0002073)	2.87308092
22	Tubular atrophy (HP:0000092)	2.85914423
23	Inability to walk (HP:0002540)	2.81495764
24	Bony spicule pigmentary retinopathy (HP:0007737)	2.77226586
25	Decreased central vision (HP:0007663)	2.77179377
26	Gaze-evoked nystagmus (HP:0000640)	2.74800450
27	Abolished electroretinogram (ERG) (HP:0000550)	2.67905996
28	Medial flaring of the eyebrow (HP:0010747)	2.67757568
29	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.64312544
30	Hypoplasia of the fovea (HP:0007750)	2.64312544
31	Febrile seizures (HP:0002373)	2.64207389
32	Pendular nystagmus (HP:0012043)	2.58507718
33	Polyuria (HP:0000103)	2.56283650
34	Abnormal respiratory motile cilium morphology (HP:0005938)	2.53206701
35	Abnormal respiratory epithelium morphology (HP:0012253)	2.53206701
36	Cystic liver disease (HP:0006706)	2.48792885
37	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.46011551
38	Hemiparesis (HP:0001269)	2.44146114
39	Cerebellar dysplasia (HP:0007033)	2.43615380
40	Renal cortical cysts (HP:0000803)	2.38675075
41	Hypothermia (HP:0002045)	2.38030930
42	Keratoconus (HP:0000563)	2.36212202
43	Increased corneal curvature (HP:0100692)	2.36212202
44	Lissencephaly (HP:0001339)	2.35307168
45	Large for gestational age (HP:0001520)	2.34563112
46	Retinal dysplasia (HP:0007973)	2.30080107
47	Abnormal ciliary motility (HP:0012262)	2.29381295
48	Abnormal urine output (HP:0012590)	2.23807802
49	Abnormality of the fovea (HP:0000493)	2.19751737
50	Abnormality of alanine metabolism (HP:0010916)	2.19646613
51	Hyperalaninemia (HP:0003348)	2.19646613
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.19646613
53	Focal motor seizures (HP:0011153)	2.19059486
54	Progressive inability to walk (HP:0002505)	2.16043425
55	Optic nerve hypoplasia (HP:0000609)	2.15072386
56	Broad-based gait (HP:0002136)	2.14594187
57	Genetic anticipation (HP:0003743)	2.11938716
58	Decreased circulating renin level (HP:0003351)	2.07305274
59	Gait imbalance (HP:0002141)	2.02592281
60	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.01576489
61	Abnormality of renal excretion (HP:0011036)	2.00132453
62	Sclerocornea (HP:0000647)	1.98684617
63	Epileptic encephalopathy (HP:0200134)	1.98107748
64	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.98021650
65	Abnormal biliary tract physiology (HP:0012439)	1.95194351
66	Bile duct proliferation (HP:0001408)	1.95194351
67	Ketosis (HP:0001946)	1.93965393
68	Abnormal respiratory motile cilium physiology (HP:0012261)	1.93651204
69	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92169948
70	Severe muscular hypotonia (HP:0006829)	1.91965439
71	Chorioretinal atrophy (HP:0000533)	1.91738231
72	Congenital hepatic fibrosis (HP:0002612)	1.91545270
73	Focal seizures (HP:0007359)	1.90802013
74	Congenital primary aphakia (HP:0007707)	1.89927651
75	Absent speech (HP:0001344)	1.89868296
76	Intestinal atresia (HP:0011100)	1.89753242
77	Hypomagnesemia (HP:0002917)	1.88772099
78	Atonic seizures (HP:0010819)	1.88170062
79	Protruding tongue (HP:0010808)	1.86391820
80	Furrowed tongue (HP:0000221)	1.85916690
81	Nephrogenic diabetes insipidus (HP:0009806)	1.85424056
82	Ketoacidosis (HP:0001993)	1.84190749
83	Anencephaly (HP:0002323)	1.80718119
84	Optic disc pallor (HP:0000543)	1.80577422
85	Amelogenesis imperfecta (HP:0000705)	1.80359771
86	Congenital sensorineural hearing impairment (HP:0008527)	1.79939335
87	Tubulointerstitial nephritis (HP:0001970)	1.79717428
88	Glycosuria (HP:0003076)	1.79672099
89	Abnormality of urine glucose concentration (HP:0011016)	1.79672099
90	Male pseudohermaphroditism (HP:0000037)	1.78676581
91	Tubulointerstitial abnormality (HP:0001969)	1.76449372
92	Pachygyria (HP:0001302)	1.75715733
93	Albinism (HP:0001022)	1.75411644
94	Genital tract atresia (HP:0001827)	1.73110606
95	Stomach cancer (HP:0012126)	1.73060037
96	Widely spaced teeth (HP:0000687)	1.70546826
97	Dialeptic seizures (HP:0011146)	1.68685230
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.68130873
99	Congenital, generalized hypertrichosis (HP:0004540)	1.65619569
100	Generalized aminoaciduria (HP:0002909)	1.63614164

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.99240144
2	MAP4K2	3.59998294
3	BMPR1B	3.12748017
4	ADRBK2	3.06205051
5	INSRR	2.70939197
6	GRK1	2.48187138
7	PINK1	2.35889972
8	ACVR1B	2.35868255
9	ZAK	2.25707674
10	DAPK2	2.23279393
11	TAOK3	2.15657474
12	WNK3	2.08151189
13	WNK4	2.03526300
14	CASK	1.97071937
15	MAPK13	1.86072575
16	PLK4	1.79167489
17	NUAK1	1.78304407
18	TLK1	1.74393716
19	PLK2	1.72790956
20	OXSR1	1.61324178
21	NTRK3	1.52008894
22	STK39	1.51809974
23	MAP3K4	1.37119681
24	PHKG1	1.23593003
25	PHKG2	1.23593003
26	PTK2B	1.22702922
27	PAK3	1.21754752
28	CAMKK2	1.21005244
29	MARK1	1.18893314
30	PNCK	1.18866217
31	MKNK2	1.16764299
32	STK38L	1.13583477
33	TXK	1.05640576
34	MAPKAPK3	1.03662256
35	ADRBK1	1.03405853
36	PRKCG	1.02983870
37	PRKCE	1.02250350
38	FGFR2	1.01637933
39	TGFBR1	0.98551634
40	MAP2K7	0.92460482
41	MAP2K6	0.88582062
42	MAPK15	0.83262379
43	CAMK1	0.74793586
44	DYRK2	0.74546591
45	MUSK	0.73862424
46	EPHA4	0.71296423
47	CSNK1G2	0.68247300
48	STK38	0.67845752
49	CSNK1G1	0.66942342
50	CAMK2A	0.66450304
51	CSNK1G3	0.65703825
52	VRK1	0.59739470
53	PRKD3	0.58889504
54	TNK2	0.58714487
55	STK11	0.58191783
56	BCKDK	0.58152002
57	TNIK	0.57978861
58	PRKCQ	0.57693203
59	IRAK1	0.56593755
60	IKBKB	0.56020754
61	CAMK1G	0.55567687
62	PKN1	0.55216973
63	MAPKAPK5	0.54342932
64	KIT	0.53648363
65	RPS6KA5	0.53332530
66	NTRK2	0.52992922
67	TRPM7	0.51888806
68	CAMKK1	0.51524704
69	CSNK1A1L	0.51071275
70	TEC	0.50439280
71	MKNK1	0.49970219
72	ERBB3	0.49795935
73	PAK6	0.49111995
74	GRK5	0.48779643
75	PRKACA	0.48432332
76	EIF2AK3	0.46925795
77	PRKG1	0.46869437
78	WNK1	0.46441351
79	TIE1	0.46069186
80	TRIM28	0.45306305
81	FER	0.44750766
82	PRKAA2	0.44603878
83	PIK3CA	0.42213462
84	CSNK1A1	0.39056489
85	MST4	0.37757362
86	ITK	0.37272534
87	PRKCZ	0.37061271
88	PRKCA	0.36464060
89	CAMK4	0.35625644
90	CSNK1D	0.35569913
91	PLK3	0.35315982
92	CDK3	0.34550864
93	BRSK2	0.34308654
94	BRD4	0.34048670
95	PRKAA1	0.33506129
96	CHUK	0.32777029
97	CAMK1D	0.31993459
98	SIK2	0.30873384
99	STK3	0.30631132
100	NLK	0.30361213

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.18898410
2	Butanoate metabolism_Homo sapiens_hsa00650	2.85697276
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.77652027
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.72043187
5	Phototransduction_Homo sapiens_hsa04744	2.66224157
6	Nicotine addiction_Homo sapiens_hsa05033	2.56011420
7	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.43287344
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.31310064
9	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.15950920
10	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.05963751
11	Olfactory transduction_Homo sapiens_hsa04740	2.02546478
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.01837199
13	Insulin secretion_Homo sapiens_hsa04911	1.82074823
14	Selenocompound metabolism_Homo sapiens_hsa00450	1.79541316
15	Morphine addiction_Homo sapiens_hsa05032	1.77199398
16	Taste transduction_Homo sapiens_hsa04742	1.74386256
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.73387918
18	Ether lipid metabolism_Homo sapiens_hsa00565	1.64959235
19	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64292727
20	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.61177409
21	GABAergic synapse_Homo sapiens_hsa04727	1.60346443
22	Circadian entrainment_Homo sapiens_hsa04713	1.60092809
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.58959480
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.50293256
25	Oxidative phosphorylation_Homo sapiens_hsa00190	1.45204781
26	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.40957507
27	Glutamatergic synapse_Homo sapiens_hsa04724	1.34179900
28	Salivary secretion_Homo sapiens_hsa04970	1.29457528
29	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.29261510
30	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.28716115
31	Serotonergic synapse_Homo sapiens_hsa04726	1.28278804
32	Protein export_Homo sapiens_hsa03060	1.27651330
33	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.23486959
34	ABC transporters_Homo sapiens_hsa02010	1.22464647
35	Caffeine metabolism_Homo sapiens_hsa00232	1.22046322
36	Cardiac muscle contraction_Homo sapiens_hsa04260	1.20735012
37	Propanoate metabolism_Homo sapiens_hsa00640	1.16952753
38	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.16874999
39	Basal transcription factors_Homo sapiens_hsa03022	1.12544228
40	Peroxisome_Homo sapiens_hsa04146	1.11861153
41	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08377107
42	Calcium signaling pathway_Homo sapiens_hsa04020	1.06874857
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.97411523
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.96338666
45	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94183211
46	Amphetamine addiction_Homo sapiens_hsa05031	0.91559147
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.91388839
48	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.91370301
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90284993
50	Parkinsons disease_Homo sapiens_hsa05012	0.89414564
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.88571951
52	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.88533273
53	Homologous recombination_Homo sapiens_hsa03440	0.87848891
54	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87392354
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87150581
56	Renin secretion_Homo sapiens_hsa04924	0.87110488
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86722574
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85813089
59	Regulation of autophagy_Homo sapiens_hsa04140	0.83948945
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.82112332
61	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.81140166
62	Retinol metabolism_Homo sapiens_hsa00830	0.79685493
63	RNA polymerase_Homo sapiens_hsa03020	0.75906427
64	Gastric acid secretion_Homo sapiens_hsa04971	0.74898292
65	Fanconi anemia pathway_Homo sapiens_hsa03460	0.74547379
66	Long-term depression_Homo sapiens_hsa04730	0.73582556
67	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.73066721
68	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72283393
69	Mineral absorption_Homo sapiens_hsa04978	0.71530333
70	RNA degradation_Homo sapiens_hsa03018	0.70693196
71	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70636198
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.70223993
73	cAMP signaling pathway_Homo sapiens_hsa04024	0.67993572
74	Alzheimers disease_Homo sapiens_hsa05010	0.66450194
75	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66191940
76	Circadian rhythm_Homo sapiens_hsa04710	0.65555332
77	Histidine metabolism_Homo sapiens_hsa00340	0.64863416
78	Fatty acid degradation_Homo sapiens_hsa00071	0.64556935
79	Glycerolipid metabolism_Homo sapiens_hsa00561	0.63696163
80	Asthma_Homo sapiens_hsa05310	0.61154854
81	Huntingtons disease_Homo sapiens_hsa05016	0.60911778
82	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.60485836
83	Cholinergic synapse_Homo sapiens_hsa04725	0.59618054
84	Purine metabolism_Homo sapiens_hsa00230	0.59400978
85	Fat digestion and absorption_Homo sapiens_hsa04975	0.55203517
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.54823864
87	Cocaine addiction_Homo sapiens_hsa05030	0.54302576
88	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.51749813
89	Metabolic pathways_Homo sapiens_hsa01100	0.49647130
90	Fatty acid metabolism_Homo sapiens_hsa01212	0.48170470
91	Allograft rejection_Homo sapiens_hsa05330	0.46869728
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.46555680
93	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.45333805
94	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.44624715
95	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.43480217
96	Graft-versus-host disease_Homo sapiens_hsa05332	0.41851442
97	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41139402
98	Pancreatic secretion_Homo sapiens_hsa04972	0.40044107
99	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.38892254
100	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.38518583

FAM153C

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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