FAM155B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a product belonging to a family of proteins with unknown function. The presence of two transmembrane domains suggests that this protein is a multi-pass membrane protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1heterochromatin organization (GO:0070828)3.91849922
2paraxial mesoderm development (GO:0048339)3.83696009
3regulation of posttranscriptional gene silencing (GO:0060147)3.73499398
4regulation of gene silencing by miRNA (GO:0060964)3.73499398
5regulation of gene silencing by RNA (GO:0060966)3.73499398
6L-serine metabolic process (GO:0006563)3.43768760
7protein complex localization (GO:0031503)3.41301913
8bundle of His cell to Purkinje myocyte communication (GO:0086069)3.40185910
9establishment of integrated proviral latency (GO:0075713)3.27884475
10DNA unwinding involved in DNA replication (GO:0006268)3.16812656
11ribosomal small subunit biogenesis (GO:0042274)3.16483269
12peptidyl-arginine omega-N-methylation (GO:0035247)3.15059297
13histone arginine methylation (GO:0034969)3.13958717
14thyroid hormone generation (GO:0006590)3.10752582
15convergent extension (GO:0060026)3.07874159
16pre-miRNA processing (GO:0031054)3.03987636
17regulation of cardioblast differentiation (GO:0051890)3.01174691
18regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.97918762
19viral transcription (GO:0019083)2.91463367
20regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.86621363
21translational termination (GO:0006415)2.83362317
22planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81176509
23cell communication by electrical coupling (GO:0010644)2.75191657
24gap junction assembly (GO:0016264)2.71932921
25regulation of stem cell maintenance (GO:2000036)2.71452580
26ventricular cardiac muscle cell action potential (GO:0086005)2.70750034
27peptidyl-arginine N-methylation (GO:0035246)2.69115979
28peptidyl-arginine methylation (GO:0018216)2.69115979
29cellular protein complex localization (GO:0034629)2.69006592
30cell communication involved in cardiac conduction (GO:0086065)2.66785152
31maturation of SSU-rRNA (GO:0030490)2.63255009
32nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.63018030
33sarcomere organization (GO:0045214)2.62245235
34prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.59141234
35regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.51721593
36negative regulation of striated muscle cell apoptotic process (GO:0010664)2.51019100
37protein-DNA complex disassembly (GO:0032986)2.50962401
38nucleosome disassembly (GO:0006337)2.50962401
39ribosomal small subunit assembly (GO:0000028)2.50719309
40regulation of mitochondrial translation (GO:0070129)2.49410711
41cell migration involved in gastrulation (GO:0042074)2.47829848
42positive regulation of cell cycle G2/M phase transition (GO:1902751)2.47346349
43positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.47346349
44translational elongation (GO:0006414)2.47199861
45cardiac myofibril assembly (GO:0055003)2.45025875
46serine family amino acid biosynthetic process (GO:0009070)2.44298726
47ventricular cardiac muscle cell development (GO:0055015)2.44078270
48regulation of translational fidelity (GO:0006450)2.41627152
49regulation of cell fate specification (GO:0042659)2.41010302
50proline biosynthetic process (GO:0006561)2.40915996
51regulation of mammary gland epithelial cell proliferation (GO:0033599)2.39542337
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.39366092
53negative regulation of microtubule polymerization (GO:0031115)2.39187538
54adult heart development (GO:0007512)2.38456899
55negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.37931456
56L-alpha-amino acid transmembrane transport (GO:1902475)2.37788404
57formation of translation preinitiation complex (GO:0001731)2.35845501
58notochord development (GO:0030903)2.35576333
59mitotic chromosome condensation (GO:0007076)2.35104515
60anterior/posterior axis specification, embryo (GO:0008595)2.34468635
61thyroid hormone metabolic process (GO:0042403)2.33232478
62lung-associated mesenchyme development (GO:0060484)2.32010460
63translational initiation (GO:0006413)2.31533318
64negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.31154726
65ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.29250068
66ventricular trabecula myocardium morphogenesis (GO:0003222)2.28033323
67SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.27092574
68regulation of NFAT protein import into nucleus (GO:0051532)2.25970779
69positive regulation of SMAD protein import into nucleus (GO:0060391)2.25901278
70establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25800202
71ectodermal placode formation (GO:0060788)2.25688505
72negative regulation of cell fate specification (GO:0009996)2.25680055
73apical protein localization (GO:0045176)2.23835039
74cotranslational protein targeting to membrane (GO:0006613)2.23150119
75ribosomal large subunit biogenesis (GO:0042273)2.22924015
76neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.22872912
77adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.21221382
78cellular protein complex disassembly (GO:0043624)2.21043731
79cardiac muscle hypertrophy (GO:0003300)2.20708339
80protein complex disassembly (GO:0043241)2.20468193
81biotin metabolic process (GO:0006768)2.20368296
82negative regulation of cell fate commitment (GO:0010454)2.19552893
83protein targeting to ER (GO:0045047)2.19410038
84cell migration in hindbrain (GO:0021535)2.19240936
85viral life cycle (GO:0019058)2.18670597
86chromatin assembly (GO:0031497)2.16681608
87cardiac muscle contraction (GO:0060048)2.16421727
88establishment of protein localization to endoplasmic reticulum (GO:0072599)2.16191412
89negative regulation of androgen receptor signaling pathway (GO:0060766)2.14589464
90atrial septum morphogenesis (GO:0060413)2.13279372
91nuclear pore organization (GO:0006999)2.12636280
92mesenchymal to epithelial transition (GO:0060231)2.11857866
93body morphogenesis (GO:0010171)2.11644603
94cardiac muscle adaptation (GO:0014887)2.11230810
95cardiac muscle hypertrophy in response to stress (GO:0014898)2.11230810
96muscle hypertrophy in response to stress (GO:0003299)2.11230810
97establishment of protein localization to mitochondrial membrane (GO:0090151)2.10853915
98establishment of viral latency (GO:0019043)2.10710082
99branching involved in salivary gland morphogenesis (GO:0060445)2.09306457
100ribonucleoprotein complex biogenesis (GO:0022613)2.07876995

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.01702058
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.40433297
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66958271
4MYC_19079543_ChIP-ChIP_MESCs_Mouse2.54611214
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.46929416
6ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.41328986
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.32148107
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.25704574
9KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.12514296
10KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.12514296
11KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.12514296
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.11221272
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.09849497
14XRN2_22483619_ChIP-Seq_HELA_Human2.06139595
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02813589
16MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98696370
17THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97811705
18ZFP281_18757296_ChIP-ChIP_E14_Mouse1.94933479
19ERG_21242973_ChIP-ChIP_JURKAT_Human1.93953879
20DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.93586343
21POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86542742
22ZNF263_19887448_ChIP-Seq_K562_Human1.86081919
23AR_21909140_ChIP-Seq_LNCAP_Human1.81211315
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.81010783
25RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80884167
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77194954
27ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72557494
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68302452
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66075564
30ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.62987986
31TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.62152944
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.61208933
33TTF2_22483619_ChIP-Seq_HELA_Human1.55810422
34KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.55559508
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53267771
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51818867
37MYCN_18555785_ChIP-Seq_MESCs_Mouse1.50582593
38CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50032198
39EZH2_22144423_ChIP-Seq_EOC_Human1.48872610
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.46564254
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.44983446
42NANOG_21062744_ChIP-ChIP_HESCs_Human1.42673415
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.39223994
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37698210
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.37451569
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37216586
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26441981
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.26392555
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26097118
50YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25844780
51E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.25784562
52RACK7_27058665_Chip-Seq_MCF-7_Human1.25500388
53POU5F1_16518401_ChIP-PET_MESCs_Mouse1.25114027
54CREB1_15753290_ChIP-ChIP_HEK293T_Human1.24977239
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.23715075
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22692913
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22578330
58E2F1_21310950_ChIP-Seq_MCF-7_Human1.20328055
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.20218145
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.19813845
61CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19120295
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18551162
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18343103
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.18315781
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17676082
66CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17383842
67KDM2B_26808549_Chip-Seq_K562_Human1.16957899
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15279674
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.14448710
70ZFP281_27345836_Chip-Seq_ESCs_Mouse1.14232838
71RING1B_27294783_Chip-Seq_NPCs_Mouse1.13417651
72CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13145621
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.12934601
74TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12488189
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.12013514
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11022662
77ETS1_20019798_ChIP-Seq_JURKAT_Human1.09714298
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.08404203
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08335313
80TP53_20018659_ChIP-ChIP_R1E_Mouse1.08193751
81TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.08094483
82OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07687302
83CHD1_26751641_Chip-Seq_LNCaP_Human1.07285749
84DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06553143
85SOX2_18692474_ChIP-Seq_MEFs_Mouse1.06400856
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.05158739
87TET1_21451524_ChIP-Seq_MESCs_Mouse1.04240092
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.03374755
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03373816
90KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03260395
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.02876574
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02618370
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.00996732
94NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.00792508
95CTCF_27219007_Chip-Seq_Bcells_Human1.00479356
96RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99873172
97EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99873172
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99763749
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.98701208
100DCP1A_22483619_ChIP-Seq_HELA_Human0.97725361

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ2.77181753
2MP0000566_synostosis2.65275481
3MP0000537_abnormal_urethra_morphology2.49660186
4MP0003890_abnormal_embryonic-extraembry2.46920305
5MP0003693_abnormal_embryo_hatching2.35307645
6MP0003123_paternal_imprinting2.33734891
7MP0010030_abnormal_orbit_morphology1.94981782
8MP0004957_abnormal_blastocyst_morpholog1.93147710
9MP0003941_abnormal_skin_development1.88775470
10MP0009672_abnormal_birth_weight1.80622976
11MP0000579_abnormal_nail_morphology1.76264235
12MP0003119_abnormal_digestive_system1.75022810
13MP0003937_abnormal_limbs/digits/tail_de1.71909694
14MP0009379_abnormal_foot_pigmentation1.67883395
15MP0002837_dystrophic_cardiac_calcinosis1.66929406
16MP0008932_abnormal_embryonic_tissue1.65188562
17MP0002234_abnormal_pharynx_morphology1.62764344
18MP0003111_abnormal_nucleus_morphology1.60003133
19MP0001730_embryonic_growth_arrest1.56936422
20MP0003136_yellow_coat_color1.56014705
21MP0002822_catalepsy1.55862487
22MP0004233_abnormal_muscle_weight1.53966720
23MP0004858_abnormal_nervous_system1.52642678
24MP0002697_abnormal_eye_size1.51436020
25MP0002249_abnormal_larynx_morphology1.51432747
26MP0005187_abnormal_penis_morphology1.48488905
27MP0003567_abnormal_fetal_cardiomyocyte1.44244417
28MP0001188_hyperpigmentation1.43440376
29MP0010630_abnormal_cardiac_muscle1.40512265
30MP0001346_abnormal_lacrimal_gland1.40285737
31MP0004133_heterotaxia1.40277411
32MP0003942_abnormal_urinary_system1.39718749
33MP0003315_abnormal_perineum_morphology1.38429174
34MP0002085_abnormal_embryonic_tissue1.32839714
35MP0000049_abnormal_middle_ear1.32445586
36MP0003122_maternal_imprinting1.32172017
37MP0002084_abnormal_developmental_patter1.29800791
38MP0006292_abnormal_olfactory_placode1.29492225
39MP0003077_abnormal_cell_cycle1.28991448
40MP0001293_anophthalmia1.27628847
41MP0004185_abnormal_adipocyte_glucose1.25879437
42MP0000751_myopathy1.25864769
43MP0003861_abnormal_nervous_system1.25375508
44MP0010094_abnormal_chromosome_stability1.23790228
45MP0005380_embryogenesis_phenotype1.23161983
46MP0001672_abnormal_embryogenesis/_devel1.23161983
47MP0002163_abnormal_gland_morphology1.19589115
48MP0003137_abnormal_impulse_conducting1.15308304
49MP0002233_abnormal_nose_morphology1.13588244
50MP0004084_abnormal_cardiac_muscle1.13443008
51MP0000762_abnormal_tongue_morphology1.11423551
52MP0003984_embryonic_growth_retardation1.10513923
53MP0002254_reproductive_system_inflammat1.08424590
54MP0000462_abnormal_digestive_system1.08237838
55MP0002088_abnormal_embryonic_growth/wei1.07920271
56MP0000778_abnormal_nervous_system1.06236893
57MP0005330_cardiomyopathy1.03733776
58MP0002796_impaired_skin_barrier1.02789434
59MP0001697_abnormal_embryo_size1.01984998
60MP0009053_abnormal_anal_canal1.01349769
61MP0005423_abnormal_somatic_nervous0.99830984
62MP0003938_abnormal_ear_development0.99321411
63MP0004270_analgesia0.98075348
64MP0004087_abnormal_muscle_fiber0.97328962
65MP0003935_abnormal_craniofacial_develop0.97282400
66MP0005409_darkened_coat_color0.96453874
67MP0000350_abnormal_cell_proliferation0.94174540
68MP0001286_abnormal_eye_development0.93694639
69MP0002080_prenatal_lethality0.93673009
70MP0000681_abnormal_thyroid_gland0.92521162
71MP0002111_abnormal_tail_morphology0.91794356
72MP0004215_abnormal_myocardial_fiber0.91542921
73MP0002089_abnormal_postnatal_growth/wei0.91462147
74MP0009703_decreased_birth_body0.90099591
75MP0005623_abnormal_meninges_morphology0.89485317
76MP0005394_taste/olfaction_phenotype0.88639163
77MP0005499_abnormal_olfactory_system0.88639163
78MP0000631_abnormal_neuroendocrine_gland0.88104462
79MP0002160_abnormal_reproductive_system0.88055307
80MP0004197_abnormal_fetal_growth/weight/0.87898310
81MP0008058_abnormal_DNA_repair0.87756720
82MP0000428_abnormal_craniofacial_morphol0.86864892
83MP0000678_abnormal_parathyroid_gland0.85024665
84MP0003121_genomic_imprinting0.83341890
85MP0005076_abnormal_cell_differentiation0.83048268
86MP0002152_abnormal_brain_morphology0.81033279
87MP0002092_abnormal_eye_morphology0.80208271
88MP0002116_abnormal_craniofacial_bone0.79734081
89MP0001299_abnormal_eye_distance/0.78720984
90MP0002184_abnormal_innervation0.78673892
91MP0002938_white_spotting0.78556333
92MP0006138_congestive_heart_failure0.77630598
93MP0006035_abnormal_mitochondrial_morpho0.77114364
94MP0001529_abnormal_vocalization0.77093278
95MP0000534_abnormal_ureter_morphology0.76708597
96MP0003755_abnormal_palate_morphology0.76138007
97MP0004885_abnormal_endolymph0.75717631
98MP0001984_abnormal_olfaction0.75008240
99MP0003705_abnormal_hypodermis_morpholog0.72890893
100MP0000955_abnormal_spinal_cord0.72696124

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)3.00220077
2Partial duplication of thumb phalanx (HP:0009944)2.98105523
3Abnormality of cochlea (HP:0000375)2.83534099
4Transposition of the great arteries (HP:0001669)2.71617237
5Abnormal connection of the cardiac segments (HP:0011545)2.71617237
6Abnormal ventriculo-arterial connection (HP:0011563)2.71617237
7Hepatoblastoma (HP:0002884)2.68695398
8Sudden death (HP:0001699)2.68013950
9Partial duplication of the phalanx of hand (HP:0009999)2.61616003
10Myokymia (HP:0002411)2.57968345
11Septate vagina (HP:0001153)2.53188534
12Choanal stenosis (HP:0000452)2.51060418
13Double outlet right ventricle (HP:0001719)2.46604747
14Congenital malformation of the right heart (HP:0011723)2.46604747
15Maternal diabetes (HP:0009800)2.46438689
16Bundle branch block (HP:0011710)2.45652309
17Aplasia/Hypoplasia of the sacrum (HP:0008517)2.39716131
18Small epiphyses (HP:0010585)2.36000767
19Ventricular tachycardia (HP:0004756)2.33624442
20Duplication of thumb phalanx (HP:0009942)2.32617486
21Reticulocytopenia (HP:0001896)2.30097127
22Absent eyebrow (HP:0002223)2.26858549
23Cortical dysplasia (HP:0002539)2.24490021
24Vaginal fistula (HP:0004320)2.22834906
25Broad distal phalanx of finger (HP:0009836)2.20696529
26Abnormality of cells of the erythroid lineage (HP:0012130)2.19048619
27Morphological abnormality of the inner ear (HP:0011390)2.10715523
28Septo-optic dysplasia (HP:0100842)2.06871314
29Goiter (HP:0000853)2.04093298
30Abnormality of the aortic arch (HP:0012303)2.03929944
31Hypoplastic left heart (HP:0004383)2.01320995
32Birth length less than 3rd percentile (HP:0003561)2.00598541
33Abnormal number of erythroid precursors (HP:0012131)2.00024348
34Progressive muscle weakness (HP:0003323)1.97619432
35Bifid scrotum (HP:0000048)1.95718139
36Esophageal atresia (HP:0002032)1.93155547
37Bilateral microphthalmos (HP:0007633)1.93029124
38High anterior hairline (HP:0009890)1.91121837
39Dysmetric saccades (HP:0000641)1.91059543
40Absent radius (HP:0003974)1.90896161
41Abnormality of the salivary glands (HP:0010286)1.90691486
42Generalized hypotonia (HP:0001290)1.90668963
43Multiple enchondromatosis (HP:0005701)1.90211369
44Preauricular pit (HP:0004467)1.89923019
45Periauricular skin pits (HP:0100277)1.89923019
46Syncope (HP:0001279)1.88131697
47Turricephaly (HP:0000262)1.88007551
48Rectal fistula (HP:0100590)1.87855356
49Rectovaginal fistula (HP:0000143)1.87855356
50Coronal craniosynostosis (HP:0004440)1.86036959
51Abnormality of the lacrimal duct (HP:0011481)1.82056426
52Atrial fibrillation (HP:0005110)1.81646359
53Facial cleft (HP:0002006)1.80374780
54Diastasis recti (HP:0001540)1.79745692
55Hyperthyroidism (HP:0000836)1.79698151
56Skin pits (HP:0100276)1.79117605
57Hyperglycinuria (HP:0003108)1.78873737
58Intestinal fistula (HP:0100819)1.78261860
59Abnormal number of incisors (HP:0011064)1.76955159
60Supraventricular tachycardia (HP:0004755)1.76257061
61Bronchomalacia (HP:0002780)1.76157405
62Absent forearm bone (HP:0003953)1.75145216
63Aplasia involving forearm bones (HP:0009822)1.75145216
64Rimmed vacuoles (HP:0003805)1.74017706
65Irregular epiphyses (HP:0010582)1.72681481
66Delayed epiphyseal ossification (HP:0002663)1.71862398
67Primary atrial arrhythmia (HP:0001692)1.71744740
68Hyperinsulinemic hypoglycemia (HP:0000825)1.71263226
69Pili torti (HP:0003777)1.70588013
70Germ cell neoplasia (HP:0100728)1.67917184
71Supraventricular arrhythmia (HP:0005115)1.67865624
72Anal stenosis (HP:0002025)1.67632667
73Hyperacusis (HP:0010780)1.67418583
74Increased nuchal translucency (HP:0010880)1.67343425
75Neonatal hypoglycemia (HP:0001998)1.67098547
76Testicular atrophy (HP:0000029)1.65788182
77Absent hair (HP:0002298)1.64389782
78Cutaneous syndactyly (HP:0012725)1.64049947
79Synostosis involving the elbow (HP:0003938)1.60599118
80Humeroradial synostosis (HP:0003041)1.60599118
81Breast hypoplasia (HP:0003187)1.60390796
82Hypoglycemic coma (HP:0001325)1.59283377
83Bicornuate uterus (HP:0000813)1.59245119
84Atresia of the external auditory canal (HP:0000413)1.59022272
85Macrocytic anemia (HP:0001972)1.58693364
86Selective tooth agenesis (HP:0001592)1.58542166
87Absent septum pellucidum (HP:0001331)1.58304420
88Preaxial foot polydactyly (HP:0001841)1.57538200
89Abnormality of the dental root (HP:0006486)1.57458426
90Taurodontia (HP:0000679)1.57458426
91Abnormality of permanent molar morphology (HP:0011071)1.57458426
92Ragged-red muscle fibers (HP:0003200)1.56643619
93Subaortic stenosis (HP:0001682)1.56594297
94Abnormality of the left ventricular outflow tract (HP:0011103)1.56594297
95Abnormality of the middle phalanges of the toes (HP:0010183)1.56549916
96Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.56471457
97Absent eyelashes (HP:0000561)1.55929688
98Anophthalmia (HP:0000528)1.55832038
99Broad thumb (HP:0011304)1.55562950
100Truncus arteriosus (HP:0001660)1.55301261

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.41465688
2EEF2K2.62670816
3SMG12.61733805
4CAMK1G2.61587806
5CAMK1D2.60865180
6MAP3K102.53768820
7VRK22.52757473
8CDK122.43845698
9CDC72.34958750
10PNCK2.30700834
11TAF12.24557746
12CASK2.15568008
13MAP3K91.98130167
14TTK1.95209762
15PRKD31.83106158
16ICK1.79676407
17SRPK11.77960324
18DMPK1.73261575
19CDK191.66401389
20TYRO31.48293788
21DYRK21.47149254
22TTN1.37457821
23LATS21.36883301
24MUSK1.29605551
25ARAF1.28051679
26TSSK61.25616952
27DYRK31.24876948
28MARK11.24725083
29BRD41.22125168
30BRAF1.21576038
31NME21.17944649
32TNIK1.16076855
33BUB11.13739825
34EPHA21.13356828
35PASK1.12814503
36STK41.11805975
37FGFR21.06964056
38AKT31.06844136
39CDK71.01708261
40CHEK20.99096711
41TAOK10.96651081
42RPS6KB20.95551122
43NME10.91894815
44MTOR0.87885715
45PKN20.86057208
46PBK0.83690917
47NTRK20.82183251
48SIK10.81022321
49PLK40.78197330
50FGFR40.74520353
51NTRK10.73038341
52BRSK10.72387885
53CSNK1E0.71744041
54AURKA0.71016135
55PINK10.70341894
56FGFR10.70037238
57UHMK10.67921322
58PLK30.67109080
59RPS6KA10.66954603
60ATR0.65430224
61PRKCI0.64943714
62WEE10.64927083
63LATS10.63999942
64MYLK0.63323204
65NEK10.62904743
66ALK0.61771606
67RPS6KL10.61071957
68RPS6KC10.61071957
69PLK10.60653766
70SGK4940.60109401
71SGK2230.60109401
72CHEK10.59938245
73STK38L0.58935302
74AKT20.58407441
75ERBB40.57056524
76CDK10.53389656
77CDK11A0.52874029
78PDGFRA0.51793569
79CDK20.51297299
80BMX0.50525849
81RPS6KA20.50329925
82ILK0.50328277
83RPS6KA60.49666190
84MKNK10.48331907
85AURKB0.47249623
86STK240.47010143
87STK160.45745477
88CDK150.45548769
89MAP2K20.45123455
90CSNK1G10.42263008
91RIPK10.41690156
92MKNK20.41516348
93PRKDC0.41218971
94ATM0.40855446
95PAK30.40653193
96CDK180.40493285
97PHKG10.40476108
98PHKG20.40476108
99NEK20.40068076
100CAMK10.38702497

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.79886568
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.26995434
3DNA replication_Homo sapiens_hsa030302.21463500
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06722134
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00830137
6Cardiac muscle contraction_Homo sapiens_hsa042601.83723932
7Spliceosome_Homo sapiens_hsa030401.69430216
8Biosynthesis of amino acids_Homo sapiens_hsa012301.67648063
9RNA transport_Homo sapiens_hsa030131.64928542
10mRNA surveillance pathway_Homo sapiens_hsa030151.63336701
11Mismatch repair_Homo sapiens_hsa034301.62285398
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54306651
13Basal cell carcinoma_Homo sapiens_hsa052171.53881842
14Thyroid hormone synthesis_Homo sapiens_hsa049181.53740792
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.50437437
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.47680027
17Arginine and proline metabolism_Homo sapiens_hsa003301.42401077
18Vitamin B6 metabolism_Homo sapiens_hsa007501.39196380
19Sulfur relay system_Homo sapiens_hsa041221.37957185
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36692834
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.36659167
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.33136732
23Base excision repair_Homo sapiens_hsa034101.31841840
24Parkinsons disease_Homo sapiens_hsa050121.29206800
25RNA polymerase_Homo sapiens_hsa030201.27429548
26Hippo signaling pathway_Homo sapiens_hsa043901.25628875
27Pyruvate metabolism_Homo sapiens_hsa006201.24042561
28Carbon metabolism_Homo sapiens_hsa012001.23948593
29Thyroid cancer_Homo sapiens_hsa052161.22113396
30Cell cycle_Homo sapiens_hsa041101.19808535
31Dilated cardiomyopathy_Homo sapiens_hsa054141.17937462
32Wnt signaling pathway_Homo sapiens_hsa043101.16118404
33One carbon pool by folate_Homo sapiens_hsa006701.13381223
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.12966874
35Oxidative phosphorylation_Homo sapiens_hsa001901.12752789
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.10870950
37Huntingtons disease_Homo sapiens_hsa050161.08935643
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06124988
39Tight junction_Homo sapiens_hsa045301.05405196
40Adherens junction_Homo sapiens_hsa045201.04440543
41Hedgehog signaling pathway_Homo sapiens_hsa043401.03267955
42Folate biosynthesis_Homo sapiens_hsa007901.01374087
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.00273991
44Lysine degradation_Homo sapiens_hsa003100.99617520
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98420281
46Steroid biosynthesis_Homo sapiens_hsa001000.98336022
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.91721320
48Fatty acid biosynthesis_Homo sapiens_hsa000610.91702993
49AMPK signaling pathway_Homo sapiens_hsa041520.89731144
50Endometrial cancer_Homo sapiens_hsa052130.88441128
51Phenylalanine metabolism_Homo sapiens_hsa003600.85449788
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84251431
53Basal transcription factors_Homo sapiens_hsa030220.83593240
54Notch signaling pathway_Homo sapiens_hsa043300.83203819
55Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.79675064
56Alzheimers disease_Homo sapiens_hsa050100.79512417
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79239568
58Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78842033
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78260680
60Arginine biosynthesis_Homo sapiens_hsa002200.78063402
61Oocyte meiosis_Homo sapiens_hsa041140.77543377
62Selenocompound metabolism_Homo sapiens_hsa004500.77132251
63Glucagon signaling pathway_Homo sapiens_hsa049220.76573223
64Cyanoamino acid metabolism_Homo sapiens_hsa004600.76546020
65Melanogenesis_Homo sapiens_hsa049160.75173762
66Insulin signaling pathway_Homo sapiens_hsa049100.74583387
67Fatty acid metabolism_Homo sapiens_hsa012120.74529240
68Pyrimidine metabolism_Homo sapiens_hsa002400.72346863
69Fatty acid elongation_Homo sapiens_hsa000620.69973469
70Nucleotide excision repair_Homo sapiens_hsa034200.68771206
71Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68492867
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66174685
73Non-homologous end-joining_Homo sapiens_hsa034500.64943108
74Axon guidance_Homo sapiens_hsa043600.64483323
75RNA degradation_Homo sapiens_hsa030180.61803036
76Tyrosine metabolism_Homo sapiens_hsa003500.61513282
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57918752
78Propanoate metabolism_Homo sapiens_hsa006400.57735892
79Pentose phosphate pathway_Homo sapiens_hsa000300.57252997
80Purine metabolism_Homo sapiens_hsa002300.55823629
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55409477
82Vitamin digestion and absorption_Homo sapiens_hsa049770.53707015
83Bladder cancer_Homo sapiens_hsa052190.53587466
84Colorectal cancer_Homo sapiens_hsa052100.52349878
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.52303673
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51999897
87TGF-beta signaling pathway_Homo sapiens_hsa043500.51615810
88ErbB signaling pathway_Homo sapiens_hsa040120.49743935
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49674751
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49142644
91Vibrio cholerae infection_Homo sapiens_hsa051100.48503785
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48206245
93Nicotine addiction_Homo sapiens_hsa050330.47842859
94Homologous recombination_Homo sapiens_hsa034400.46725496
95Melanoma_Homo sapiens_hsa052180.46393035
96Prostate cancer_Homo sapiens_hsa052150.46179520
97Gap junction_Homo sapiens_hsa045400.45473501
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44698159
99Galactose metabolism_Homo sapiens_hsa000520.42851016
100Insulin secretion_Homo sapiens_hsa049110.41224318

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