FAM156A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mannose metabolic process (GO:0006013)4.69248456
2positive regulation of osteoblast proliferation (GO:0033690)4.62160928
3response to follicle-stimulating hormone (GO:0032354)4.05979515
4negative regulation of gluconeogenesis (GO:0045721)3.99196416
5regulation of ARF GTPase activity (GO:0032312)3.82703108
6cell-cell junction maintenance (GO:0045217)3.81317449
7histone H4 deacetylation (GO:0070933)3.74397824
8diacylglycerol metabolic process (GO:0046339)3.66033412
9nephron epithelium morphogenesis (GO:0072088)3.48816408
10nephron tubule morphogenesis (GO:0072078)3.48816408
11negative regulation of erythrocyte differentiation (GO:0045647)3.47472756
12locomotory exploration behavior (GO:0035641)3.38245019
13histone H3 deacetylation (GO:0070932)3.38103291
14convergent extension (GO:0060026)3.29030188
15negative regulation of fibrinolysis (GO:0051918)3.27949194
16semaphorin-plexin signaling pathway (GO:0071526)3.27615040
17cell migration in hindbrain (GO:0021535)3.22309834
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.19347643
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.19250699
20basement membrane organization (GO:0071711)3.18151071
21positive regulation of CREB transcription factor activity (GO:0032793)3.16075163
22camera-type eye morphogenesis (GO:0048593)3.14315451
23layer formation in cerebral cortex (GO:0021819)3.05584452
24cranial nerve morphogenesis (GO:0021602)3.04480782
25bone trabecula formation (GO:0060346)3.02633761
26establishment of mitochondrion localization (GO:0051654)3.02173260
27establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.00939937
28mitochondrion transport along microtubule (GO:0047497)3.00939937
29head development (GO:0060322)2.97296520
30estrogen biosynthetic process (GO:0006703)2.96436105
31negative regulation of granulocyte differentiation (GO:0030853)2.95017765
32spliceosomal tri-snRNP complex assembly (GO:0000244)2.94804167
33peptidyl-glutamic acid carboxylation (GO:0017187)2.93943446
34protein carboxylation (GO:0018214)2.93943446
35cell junction maintenance (GO:0034331)2.92177948
36cochlea morphogenesis (GO:0090103)2.90593190
37positive regulation of dendrite morphogenesis (GO:0050775)2.88979762
38embryonic process involved in female pregnancy (GO:0060136)2.88426604
39histone H3-K9 demethylation (GO:0033169)2.87067389
40regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.84932351
41positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.84764715
42cellular response to prostaglandin stimulus (GO:0071379)2.83550315
43regulation of gonadotropin secretion (GO:0032276)2.80981283
44receptor recycling (GO:0001881)2.80577396
45regulation of glycogen (starch) synthase activity (GO:2000465)2.79847464
46retrograde transport, endosome to Golgi (GO:0042147)2.79819318
47protein retention in ER lumen (GO:0006621)2.79208261
48negative regulation of autophagy (GO:0010507)2.71271309
49sulfate transmembrane transport (GO:1902358)2.68607382
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68116400
51neuronal stem cell maintenance (GO:0097150)2.67833069
52negative regulation of bone mineralization (GO:0030502)2.66653836
53regulation of non-canonical Wnt signaling pathway (GO:2000050)2.66221883
54phosphatidylglycerol biosynthetic process (GO:0006655)2.65667427
55body morphogenesis (GO:0010171)2.64456176
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.62952884
57negative regulation of biomineral tissue development (GO:0070168)2.60514145
58regulation of ARF protein signal transduction (GO:0032012)2.59982666
59histone H3-K4 trimethylation (GO:0080182)2.59600598
60regulation of axon extension involved in axon guidance (GO:0048841)2.57396865
61regulation of glutamate receptor signaling pathway (GO:1900449)2.57242665
62maternal placenta development (GO:0001893)2.57069527
63regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.57061969
64negative regulation of Ras protein signal transduction (GO:0046580)2.56661827
65positive regulation of protein kinase C signaling (GO:0090037)2.53937627
66glomerular basement membrane development (GO:0032836)2.52330907
67negative regulation of small GTPase mediated signal transduction (GO:0051058)2.52206654
68renal tubule morphogenesis (GO:0061333)2.51946305
69histone deubiquitination (GO:0016578)2.51439770
70regulation of monocyte differentiation (GO:0045655)2.49861679
71positive regulation of odontogenesis (GO:0042482)2.47229683
72positive regulation of collagen biosynthetic process (GO:0032967)2.46391467
73negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.46021549
74negative regulation of Rho protein signal transduction (GO:0035024)2.45448529
75negative regulation of macroautophagy (GO:0016242)2.45427021
76cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.45016461
77regulation of establishment of planar polarity (GO:0090175)2.44511186
78negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.44460596
79granulocyte differentiation (GO:0030851)2.44088576
80glucocorticoid biosynthetic process (GO:0006704)2.43997065
81poly(A)+ mRNA export from nucleus (GO:0016973)2.43934545
82positive regulation of insulin receptor signaling pathway (GO:0046628)2.43528356
83cellular response to epidermal growth factor stimulus (GO:0071364)2.42877230
84activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42225222
85positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.41365176
86sulfate transport (GO:0008272)2.41177972
87regulation of cholesterol metabolic process (GO:0090181)2.40934880
88proline biosynthetic process (GO:0006561)2.40175119
89collecting duct development (GO:0072044)2.38965872
90regulation of axon guidance (GO:1902667)2.37736695
91eye morphogenesis (GO:0048592)2.36673544
92erythrocyte development (GO:0048821)2.36007276
93regulation of plasminogen activation (GO:0010755)2.35684924
94positive regulation of synapse maturation (GO:0090129)2.34132670
95stress granule assembly (GO:0034063)2.33829751
96collagen fibril organization (GO:0030199)2.32273330
97regulation of collagen biosynthetic process (GO:0032965)2.32145197
98positive regulation of collagen metabolic process (GO:0010714)2.31570077
99positive regulation of nuclease activity (GO:0032075)2.31448602
100cardiac muscle cell proliferation (GO:0060038)2.30468639

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.50963789
2MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.10634572
3EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.06525087
4LXR_22292898_ChIP-Seq_THP-1_Human2.88388311
5VDR_21846776_ChIP-Seq_THP-1_Human2.83906501
6CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.54988580
7MYC_22102868_ChIP-Seq_BL_Human2.52015953
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.50364377
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.39545763
10KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35987675
11ERG_21242973_ChIP-ChIP_JURKAT_Human2.33007238
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.32291423
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.18721835
14KDM2B_26808549_Chip-Seq_DND41_Human2.17640047
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.15701269
16IKZF1_21737484_ChIP-ChIP_HCT116_Human2.09876167
17ELK3_25401928_ChIP-Seq_HUVEC_Human2.07772858
18P68_20966046_ChIP-Seq_HELA_Human2.01921036
19KDM2B_26808549_Chip-Seq_K562_Human2.01162558
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.99270293
21ZNF263_19887448_ChIP-Seq_K562_Human1.98240840
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.96910462
23EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.94744801
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.92937185
25TP53_22127205_ChIP-Seq_IMR90_Human1.90523781
26SMC4_20622854_ChIP-Seq_HELA_Human1.88815959
27ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.76788191
28SA1_27219007_Chip-Seq_ERYTHROID_Human1.76297139
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.74981913
30ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74875728
31TCF7_22412390_ChIP-Seq_EML_Mouse1.73469089
32KDM2B_26808549_Chip-Seq_JURKAT_Human1.68746690
33RACK7_27058665_Chip-Seq_MCF-7_Human1.68667829
34TET1_21451524_ChIP-Seq_MESCs_Mouse1.67423838
35DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.62447610
36KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.59008282
37ELF1_20517297_ChIP-Seq_JURKAT_Human1.54163990
38EZH2_22144423_ChIP-Seq_EOC_Human1.53314593
39* MAF_26560356_Chip-Seq_TH2_Human1.51898114
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51588552
41CTCF_27219007_Chip-Seq_ERYTHROID_Human1.50024669
42CREB1_26743006_Chip-Seq_LNCaP_Human1.46682225
43DROSHA_22980978_ChIP-Seq_HELA_Human1.46503698
44MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.46142886
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43888161
46TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.43711037
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41867418
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40661825
49CLOCK_20551151_ChIP-Seq_293T_Human1.40527686
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40062315
51SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.36822813
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.32174833
53BCL6_27268052_Chip-Seq_Bcells_Human1.30842642
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29860225
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29191743
56CTCF_27219007_Chip-Seq_Bcells_Human1.24748007
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22656349
58NCOR1_26117541_ChIP-Seq_K562_Human1.22277623
59RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21797543
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21191381
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19927762
62PHF8_20622854_ChIP-Seq_HELA_Human1.18005584
63SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17808238
64SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16295584
65HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15897730
66RARA_24833708_ChIP-Seq_LIVER_Mouse1.15867910
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.15810143
68* RUNX1_27514584_Chip-Seq_MCF-7_Human1.15106447
69ELK4_26923725_Chip-Seq_MESODERM_Mouse1.14456333
70OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13600782
71CIITA_25753668_ChIP-Seq_RAJI_Human1.12865992
72MAF_26560356_Chip-Seq_TH1_Human1.12436783
73NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12089326
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.11378271
75ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11214626
76CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10860158
77BCOR_27268052_Chip-Seq_Bcells_Human1.10672242
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.09117202
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09103580
80SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08584374
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08291161
82E2F1_20622854_ChIP-Seq_HELA_Human1.07236774
83SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06545601
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05500621
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.04839323
86TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04002378
87EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03890167
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03890167
89TET1_21490601_ChIP-Seq_MESCs_Mouse1.02924372
90RARB_27405468_Chip-Seq_BRAIN_Mouse1.02501668
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.02258994
92SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01270628
93CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00746144
94VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99259576
95OCT4_19829295_ChIP-Seq_ESCs_Human0.99155274
96JARID2_20075857_ChIP-Seq_MESCs_Mouse0.98132085
97CTCF_26484167_Chip-Seq_Bcells_Mouse0.98075369
98RNF2_27304074_Chip-Seq_ESCs_Mouse0.97702085
99JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97445886
100UTX_26944678_Chip-Seq_JUKART_Human0.96364056

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003122_maternal_imprinting4.16893249
2MP0002249_abnormal_larynx_morphology3.23934277
3MP0003705_abnormal_hypodermis_morpholog3.08896524
4MP0002132_abnormal_respiratory_system3.06273238
5MP0008438_abnormal_cutaneous_collagen3.03878249
6MP0009384_cardiac_valve_regurgitation2.99566933
7MP0005503_abnormal_tendon_morphology2.63465831
8MP0009278_abnormal_bone_marrow2.48447208
9MP0005058_abnormal_lysosome_morphology2.47350326
10MP0006292_abnormal_olfactory_placode2.35467968
11MP0000003_abnormal_adipose_tissue2.35315344
12MP0001661_extended_life_span2.32814169
13MP0005360_urolithiasis2.27829539
14MP0003123_paternal_imprinting2.24674318
15MP0003172_abnormal_lysosome_physiology2.20828726
16MP0001958_emphysema2.13547191
17MP0003942_abnormal_urinary_system2.03170708
18MP0004858_abnormal_nervous_system1.99948400
19MP0005076_abnormal_cell_differentiation1.94357131
20MP0001849_ear_inflammation1.79189092
21MP0010030_abnormal_orbit_morphology1.72997890
22MP0008260_abnormal_autophagy1.69482531
23MP0001270_distended_abdomen1.62144970
24MP0001348_abnormal_lacrimal_gland1.57632172
25MP0003279_aneurysm1.52237623
26MP0003115_abnormal_respiratory_system1.51991865
27MP0004859_abnormal_synaptic_plasticity1.49628553
28MP0003385_abnormal_body_wall1.48056609
29MP0003183_abnormal_peptide_metabolism1.46981951
30MP0005257_abnormal_intraocular_pressure1.46203900
31MP0002971_abnormal_brown_adipose1.46113906
32MP0002108_abnormal_muscle_morphology1.42425109
33MP0003121_genomic_imprinting1.42330886
34MP0000639_abnormal_adrenal_gland1.39703566
35MP0005375_adipose_tissue_phenotype1.39094686
36MP0005397_hematopoietic_system_phenotyp1.36512269
37MP0001545_abnormal_hematopoietic_system1.36512269
38MP0000751_myopathy1.34020222
39MP0000767_abnormal_smooth_muscle1.33476655
40MP0001502_abnormal_circadian_rhythm1.32909638
41MP0003566_abnormal_cell_adhesion1.27848860
42MP0000049_abnormal_middle_ear1.26712906
43MP0000013_abnormal_adipose_tissue1.25260720
44MP0005666_abnormal_adipose_tissue1.24744637
45MP0005499_abnormal_olfactory_system1.22610539
46MP0005394_taste/olfaction_phenotype1.22610539
47MP0002932_abnormal_joint_morphology1.21409099
48MP0003091_abnormal_cell_migration1.21288938
49MP0002116_abnormal_craniofacial_bone1.20874475
50MP0005377_hearing/vestibular/ear_phenot1.14165522
51MP0003878_abnormal_ear_physiology1.14165522
52MP0002933_joint_inflammation1.13238423
53MP0009115_abnormal_fat_cell1.12579603
54MP0000778_abnormal_nervous_system1.08055829
55MP0008875_abnormal_xenobiotic_pharmacok1.06543320
56MP0003755_abnormal_palate_morphology1.06002106
57MP0002970_abnormal_white_adipose1.03021914
58MP0005365_abnormal_bile_salt1.01714291
59MP0005508_abnormal_skeleton_morphology1.01408078
60MP0002092_abnormal_eye_morphology1.00811359
61MP0010630_abnormal_cardiac_muscle0.96978065
62MP0000747_muscle_weakness0.94345515
63MP0000762_abnormal_tongue_morphology0.93515298
64MP0010368_abnormal_lymphatic_system0.91628936
65MP0004130_abnormal_muscle_cell0.90657982
66MP0000534_abnormal_ureter_morphology0.90112120
67MP0002114_abnormal_axial_skeleton0.88962791
68MP0006276_abnormal_autonomic_nervous0.88642307
69MP0004197_abnormal_fetal_growth/weight/0.87654067
70MP0003436_decreased_susceptibility_to0.86883758
71MP0000759_abnormal_skeletal_muscle0.86519208
72MP0004185_abnormal_adipocyte_glucose0.80820049
73MP0003938_abnormal_ear_development0.80142049
74MP0001915_intracranial_hemorrhage0.79571955
75MP0008789_abnormal_olfactory_epithelium0.78680599
76MP0001614_abnormal_blood_vessel0.76988600
77MP0003329_amyloid_beta_deposits0.74661331
78MP0005670_abnormal_white_adipose0.74374218
79MP0002925_abnormal_cardiovascular_devel0.74273994
80MP0001175_abnormal_lung_morphology0.74133355
81MP0002113_abnormal_skeleton_development0.72912898
82MP0000733_abnormal_muscle_development0.72835981
83MP0000163_abnormal_cartilage_morphology0.72621801
84MP0001943_abnormal_respiration0.71513266
85MP0003861_abnormal_nervous_system0.70750937
86MP0005388_respiratory_system_phenotype0.70596031
87MP0002133_abnormal_respiratory_system0.70596031
88MP0002152_abnormal_brain_morphology0.70126495
89MP0006138_congestive_heart_failure0.67651266
90MP0000955_abnormal_spinal_cord0.67567259
91MP0004087_abnormal_muscle_fiber0.67268207
92MP0004272_abnormal_basement_membrane0.66278751
93MP0002111_abnormal_tail_morphology0.65379502
94MP0002063_abnormal_learning/memory/cond0.65156920
95MP0004811_abnormal_neuron_physiology0.64795748
96MP0001286_abnormal_eye_development0.63395605
97MP0002089_abnormal_postnatal_growth/wei0.63006512
98MP0002128_abnormal_blood_circulation0.63003580
99MP0000428_abnormal_craniofacial_morphol0.62466462
100MP0001299_abnormal_eye_distance/0.61916694

Predicted human phenotypes

RankGene SetZ-score
1Broad palm (HP:0001169)4.59993997
2Protrusio acetabuli (HP:0003179)4.34824202
3Cervical subluxation (HP:0003308)3.49689339
4Biconcave vertebral bodies (HP:0004586)3.42823334
5Broad face (HP:0000283)3.13489545
6Premature rupture of membranes (HP:0001788)3.12889160
7Thin bony cortex (HP:0002753)3.02116638
8Facial hemangioma (HP:0000329)3.01886742
9Metaphyseal cupping (HP:0003021)2.97322403
10Poikiloderma (HP:0001029)2.87970414
11Reticulocytosis (HP:0001923)2.84009213
12Deep venous thrombosis (HP:0002625)2.79305299
13Peritonitis (HP:0002586)2.73851070
14Flat acetabular roof (HP:0003180)2.68846972
15Abnormality of the acetabulum (HP:0003170)2.60883409
16Mitral regurgitation (HP:0001653)2.57404679
17Aortic dissection (HP:0002647)2.54999798
18Ulnar bowing (HP:0003031)2.54928460
19Heterotopia (HP:0002282)2.54144558
20Abnormality of dentin (HP:0010299)2.49854725
21Bladder diverticulum (HP:0000015)2.46821615
22Disproportionate tall stature (HP:0001519)2.43916668
23Entropion (HP:0000621)2.43294868
24Annular pancreas (HP:0001734)2.42108007
25Aortic regurgitation (HP:0001659)2.37877650
26Abnormality of DNA repair (HP:0003254)2.34526046
27Trigonocephaly (HP:0000243)2.33638669
28Papilledema (HP:0001085)2.32953400
29Hyperacusis (HP:0010780)2.30446388
30Arterial tortuosity (HP:0005116)2.28960329
31Cupped ribs (HP:0000887)2.26957815
32Turricephaly (HP:0000262)2.25904817
33Hemorrhage of the eye (HP:0011885)2.24911004
34Abnormality of the peritoneum (HP:0002585)2.24674265
35Deep palmar crease (HP:0006191)2.23469148
36Thin ribs (HP:0000883)2.19528204
37Capillary hemangiomas (HP:0005306)2.17641479
38J-shaped sella turcica (HP:0002680)2.16527601
39Abnormality of reticulocytes (HP:0004312)2.14995438
40Spinal cord lesions (HP:0100561)2.12070275
41Syringomyelia (HP:0003396)2.12070275
42Joint stiffness (HP:0001387)2.11749044
43Short 5th finger (HP:0009237)2.11368157
44Stridor (HP:0010307)2.11254681
45Spinal canal stenosis (HP:0003416)2.09224336
46Dislocated radial head (HP:0003083)2.08566056
47Vascular tortuosity (HP:0004948)2.08031211
48Abnormality of the calcaneus (HP:0008364)2.07313407
49Soft skin (HP:0000977)2.06554620
50Broad alveolar ridges (HP:0000187)2.05622396
51Acanthocytosis (HP:0001927)2.04415390
52Inguinal hernia (HP:0000023)1.97495515
53Pointed chin (HP:0000307)1.96398873
54Joint laxity (HP:0001388)1.94913529
55Polycythemia (HP:0001901)1.94641117
56Renal duplication (HP:0000075)1.92819625
57Abnormality of the thoracic spine (HP:0100711)1.90652197
58Shallow orbits (HP:0000586)1.90575076
59Abnormality of the lumbar spine (HP:0100712)1.90126493
60Vitreoretinal degeneration (HP:0000655)1.89547965
61Absent epiphyses (HP:0010577)1.89200325
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.89200325
63Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88860650
64Venous insufficiency (HP:0005293)1.88841800
65Obstructive sleep apnea (HP:0002870)1.88465318
66Abnormality of the radial head (HP:0003995)1.86860484
67Cerebral aneurysm (HP:0004944)1.85548568
68Venous abnormality (HP:0002624)1.84339829
69Urinary glycosaminoglycan excretion (HP:0003541)1.84295353
70Mucopolysacchariduria (HP:0008155)1.84295353
71Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83862807
72Hypercholesterolemia (HP:0003124)1.79834131
73Abnormality of the lower motor neuron (HP:0002366)1.79703226
74Mitral valve prolapse (HP:0001634)1.79629528
75Blue sclerae (HP:0000592)1.77396708
76Camptodactyly of toe (HP:0001836)1.76484461
77Abnormality of carpal bone ossification (HP:0006257)1.76377273
78Wide nose (HP:0000445)1.76046220
79Mesangial abnormality (HP:0001966)1.75883308
80Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.75839237
81Rhizomelia (HP:0008905)1.75549868
82Upper limb amyotrophy (HP:0009129)1.75405717
83Distal upper limb amyotrophy (HP:0007149)1.75405717
84Abnormality of skull ossification (HP:0002703)1.74839086
85Supernumerary nipples (HP:0002558)1.74446129
86Abnormal vertebral ossification (HP:0100569)1.73620959
87Insomnia (HP:0100785)1.72397736
88Rectal prolapse (HP:0002035)1.72329619
89Broad metatarsal (HP:0001783)1.72103637
90Aneurysm (HP:0002617)1.70506792
9111 pairs of ribs (HP:0000878)1.69637114
92Broad phalanges of the hand (HP:0009768)1.69527530
93Coarse hair (HP:0002208)1.69406676
94Thoracic kyphosis (HP:0002942)1.67935348
95Neonatal short-limb short stature (HP:0008921)1.67880667
96Short 4th metacarpal (HP:0010044)1.67744340
97Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.67744340
98Aortic aneurysm (HP:0004942)1.67040288
99Broad finger (HP:0001500)1.67021562
100Abnormality of the humeroradial joint (HP:0100744)1.65454884

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.86939119
2ERN13.29554498
3WNK43.02062294
4CDK123.01027130
5PDGFRA2.87603308
6ICK2.82994369
7FGFR42.72418420
8PRPF4B2.50927582
9MAP2K32.31850117
10TYRO32.31456969
11SIK22.30321777
12MAP3K72.15323434
13MAP3K132.06792042
14PDK21.97938534
15EEF2K1.94544465
16MAP2K41.74823127
17SIK11.70521396
18MARK21.52307921
19WNK11.42518899
20MAPK121.37702045
21MAP3K61.36382788
22MAP3K101.31609084
23AKT31.30013654
24DDR21.27422582
25TYK21.26051850
26NTRK11.25019462
27MTOR1.24212242
28NTRK21.23981112
29FGFR31.22510392
30EPHB11.18313835
31MAPK111.14678106
32CDC42BPA1.12634361
33PDPK11.10749258
34CDK81.09670100
35MOS1.06402936
36RPS6KA21.04617472
37DYRK1B1.00241263
38TTN0.95253516
39BLK0.90663056
40RPS6KC10.88480728
41RPS6KL10.88480728
42PDGFRB0.87852074
43RIPK10.87116658
44MAP2K60.86445899
45SMG10.85023666
46MAPK70.84455903
47PTK60.83958548
48KSR20.80685488
49MUSK0.79112986
50PKN20.78541602
51PRKD20.77666196
52RET0.75408739
53JAK30.75017744
54CAMKK10.74874740
55FGFR20.74694807
56GRK60.73843459
57PDK10.71989281
58CDK40.71888507
59RPS6KA60.71525792
60DYRK1A0.70983498
61LATS10.70569437
62NME10.69858539
63PIK3CA0.68765973
64ZAP700.67615340
65STK390.63346750
66NEK20.58369305
67CAMK1D0.57478512
68RIPK40.54028757
69PTK20.51434028
70PRKD10.48988456
71MAP3K110.48654230
72MAPK100.48561514
73FLT30.47435677
74MAPK10.47356626
75TNK20.46990347
76ARAF0.46526394
77MAPK30.43275935
78MAPK40.41813735
79SRC0.41506073
80MET0.40773452
81JAK20.40627768
82BRD40.40618058
83CDK70.40369101
84BMX0.38922910
85MAPK150.38697425
86AKT10.37038815
87TGFBR20.36907428
88MAP2K20.35314395
89UHMK10.32432211
90MAPK80.32295685
91CAMK1G0.31208351
92ATR0.30898412
93PRKAA10.30653251
94STK110.30548738
95BRAF0.27712851
96MAPK140.27325754
97MAPKAPK50.27012291
98RPS6KB10.26570896
99CDK20.26467047
100CDK60.26242971

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005313.34743643
2Other glycan degradation_Homo sapiens_hsa005113.26347412
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.91396518
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.60835273
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.39718275
6Notch signaling pathway_Homo sapiens_hsa043302.38970361
7Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.82264820
8Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.79848806
9Non-small cell lung cancer_Homo sapiens_hsa052231.62452295
10Complement and coagulation cascades_Homo sapiens_hsa046101.61439575
11Choline metabolism in cancer_Homo sapiens_hsa052311.60270040
12GnRH signaling pathway_Homo sapiens_hsa049121.57076776
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.55973494
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52977892
15Lysine degradation_Homo sapiens_hsa003101.44537649
16VEGF signaling pathway_Homo sapiens_hsa043701.42719172
17Chronic myeloid leukemia_Homo sapiens_hsa052201.38389922
18Neurotrophin signaling pathway_Homo sapiens_hsa047221.36680519
19mTOR signaling pathway_Homo sapiens_hsa041501.35559115
20ECM-receptor interaction_Homo sapiens_hsa045121.33632203
21Phospholipase D signaling pathway_Homo sapiens_hsa040721.30741955
22Axon guidance_Homo sapiens_hsa043601.27692196
23Basal cell carcinoma_Homo sapiens_hsa052171.20687635
24mRNA surveillance pathway_Homo sapiens_hsa030151.17772543
25ErbB signaling pathway_Homo sapiens_hsa040121.16348927
26Prolactin signaling pathway_Homo sapiens_hsa049171.15875234
27Thyroid hormone signaling pathway_Homo sapiens_hsa049191.12717048
28Adipocytokine signaling pathway_Homo sapiens_hsa049201.11597288
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10600719
30ABC transporters_Homo sapiens_hsa020101.10378213
31Acute myeloid leukemia_Homo sapiens_hsa052211.06993550
32Glycerophospholipid metabolism_Homo sapiens_hsa005641.06483568
33Central carbon metabolism in cancer_Homo sapiens_hsa052301.05504368
34Focal adhesion_Homo sapiens_hsa045101.05328428
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05303648
36AMPK signaling pathway_Homo sapiens_hsa041521.05270660
37Glioma_Homo sapiens_hsa052141.03891870
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03324406
39Bladder cancer_Homo sapiens_hsa052191.02662215
40Pancreatic cancer_Homo sapiens_hsa052120.97880495
41Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93975743
42Ovarian steroidogenesis_Homo sapiens_hsa049130.93333578
43PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92538587
44Biosynthesis of amino acids_Homo sapiens_hsa012300.91903244
45Hedgehog signaling pathway_Homo sapiens_hsa043400.91331192
46Dorso-ventral axis formation_Homo sapiens_hsa043200.90631357
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88740998
48Sulfur relay system_Homo sapiens_hsa041220.88078476
49Inositol phosphate metabolism_Homo sapiens_hsa005620.85506226
50Endometrial cancer_Homo sapiens_hsa052130.82927658
51MicroRNAs in cancer_Homo sapiens_hsa052060.81499369
52Small cell lung cancer_Homo sapiens_hsa052220.80681208
53Proteoglycans in cancer_Homo sapiens_hsa052050.78904882
54Prion diseases_Homo sapiens_hsa050200.78820592
55Insulin signaling pathway_Homo sapiens_hsa049100.78737906
56HIF-1 signaling pathway_Homo sapiens_hsa040660.78056960
57Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.77763748
58Hepatitis B_Homo sapiens_hsa051610.76658131
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76431331
60N-Glycan biosynthesis_Homo sapiens_hsa005100.76406163
61Thyroid hormone synthesis_Homo sapiens_hsa049180.76102970
62B cell receptor signaling pathway_Homo sapiens_hsa046620.74613832
63Fructose and mannose metabolism_Homo sapiens_hsa000510.72097956
64MAPK signaling pathway_Homo sapiens_hsa040100.71056539
65Renal cell carcinoma_Homo sapiens_hsa052110.68123115
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67578791
67Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66534109
68Estrogen signaling pathway_Homo sapiens_hsa049150.66227562
69Bile secretion_Homo sapiens_hsa049760.65344467
70Rap1 signaling pathway_Homo sapiens_hsa040150.63070188
71Ras signaling pathway_Homo sapiens_hsa040140.61691200
72Melanogenesis_Homo sapiens_hsa049160.59834104
73Colorectal cancer_Homo sapiens_hsa052100.58882217
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.58623287
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57173810
76Fanconi anemia pathway_Homo sapiens_hsa034600.57057868
77Endocytosis_Homo sapiens_hsa041440.56625170
78Dilated cardiomyopathy_Homo sapiens_hsa054140.53294766
79Pathways in cancer_Homo sapiens_hsa052000.52160146
80Staphylococcus aureus infection_Homo sapiens_hsa051500.51989116
81Hippo signaling pathway_Homo sapiens_hsa043900.51394845
82Insulin resistance_Homo sapiens_hsa049310.50811263
83Fatty acid metabolism_Homo sapiens_hsa012120.49936074
84Pentose phosphate pathway_Homo sapiens_hsa000300.49404617
85Glucagon signaling pathway_Homo sapiens_hsa049220.49261317
86Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48959314
87Base excision repair_Homo sapiens_hsa034100.48856588
88FoxO signaling pathway_Homo sapiens_hsa040680.48423215
89Oxytocin signaling pathway_Homo sapiens_hsa049210.46933639
90Osteoclast differentiation_Homo sapiens_hsa043800.46738985
91Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.46675603
92PPAR signaling pathway_Homo sapiens_hsa033200.46521030
93Histidine metabolism_Homo sapiens_hsa003400.44179678
94Leishmaniasis_Homo sapiens_hsa051400.44163538
95Cholinergic synapse_Homo sapiens_hsa047250.43658851
96Protein digestion and absorption_Homo sapiens_hsa049740.42145763
97HTLV-I infection_Homo sapiens_hsa051660.41592993
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40583331
99Glycerolipid metabolism_Homo sapiens_hsa005610.39287057
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.38362983

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