FAM156B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)4.85298443
2mannose metabolic process (GO:0006013)4.84444817
3regulation of ARF GTPase activity (GO:0032312)4.59746426
4COPI coating of Golgi vesicle (GO:0048205)4.41407973
5Golgi transport vesicle coating (GO:0048200)4.41407973
6protein retention in ER lumen (GO:0006621)4.16245206
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.01550395
8negative regulation of erythrocyte differentiation (GO:0045647)4.01370727
9histone H4 deacetylation (GO:0070933)4.00178162
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.98776355
11barbed-end actin filament capping (GO:0051016)3.92761061
12histone H3 deacetylation (GO:0070932)3.82788176
13regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.80685481
14establishment of mitochondrion localization (GO:0051654)3.79081206
15negative regulation of cell size (GO:0045792)3.74766649
16synaptic vesicle exocytosis (GO:0016079)3.69855780
17semaphorin-plexin signaling pathway (GO:0071526)3.59404862
18establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.44071363
19mitochondrion transport along microtubule (GO:0047497)3.44071363
20negative regulation of smooth muscle cell migration (GO:0014912)3.37428597
21Arp2/3 complex-mediated actin nucleation (GO:0034314)3.36525486
22chondroitin sulfate catabolic process (GO:0030207)3.27343449
23entrainment of circadian clock by photoperiod (GO:0043153)3.24993939
24actin filament depolymerization (GO:0030042)3.21605652
25positive regulation of protein kinase C signaling (GO:0090037)3.21195722
26phosphatidylglycerol biosynthetic process (GO:0006655)3.11983490
27stress fiber assembly (GO:0043149)3.08046183
28regulation of synaptic vesicle exocytosis (GO:2000300)3.06026152
29UV protection (GO:0009650)3.04773295
30positive regulation of triglyceride lipase activity (GO:0061365)3.04575685
31positive regulation of lipoprotein lipase activity (GO:0051006)3.04575685
32negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.02378641
33retrograde transport, endosome to Golgi (GO:0042147)3.00253772
34positive regulation of protein dephosphorylation (GO:0035307)2.97681502
35activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.97272509
36amino sugar catabolic process (GO:0046348)2.88699453
37synaptic vesicle maturation (GO:0016188)2.87025248
38mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.86159073
39cell-cell junction maintenance (GO:0045217)2.85587023
40positive regulation of nuclease activity (GO:0032075)2.81036893
41regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.75973486
42regulation of cholesterol metabolic process (GO:0090181)2.72460810
43endothelial cell chemotaxis (GO:0035767)2.71979480
44regulation of T-helper 2 cell differentiation (GO:0045628)2.69855491
45GDP-mannose metabolic process (GO:0019673)2.69135623
46protein kinase C signaling (GO:0070528)2.67147016
47glutamate secretion (GO:0014047)2.66115224
48protein insertion into membrane (GO:0051205)2.64748134
49NADH metabolic process (GO:0006734)2.63687251
50positive regulation of receptor recycling (GO:0001921)2.63473972
51negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.63394357
52basement membrane organization (GO:0071711)2.57739124
53extracellular fibril organization (GO:0043206)2.56943580
54pyrimidine-containing compound salvage (GO:0008655)2.56070789
55pyrimidine nucleoside salvage (GO:0043097)2.56070789
56cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.53035620
57protein maturation by protein folding (GO:0022417)2.52620804
58cell volume homeostasis (GO:0006884)2.52059539
59positive regulation of monocyte chemotaxis (GO:0090026)2.51016489
60maintenance of protein localization in organelle (GO:0072595)2.50192214
61fibril organization (GO:0097435)2.49729978
62regulation of hydrogen peroxide metabolic process (GO:0010310)2.49407160
63positive regulation of synapse maturation (GO:0090129)2.49061148
64protein heterotrimerization (GO:0070208)2.48299308
65regulation of nuclease activity (GO:0032069)2.47809582
66histone H4-K12 acetylation (GO:0043983)2.45094464
67proline biosynthetic process (GO:0006561)2.43746979
68regulation of monocyte chemotaxis (GO:0090025)2.42488566
69viral protein processing (GO:0019082)2.41969244
70actin nucleation (GO:0045010)2.41509496
71poly(A)+ mRNA export from nucleus (GO:0016973)2.41437789
72vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.40085221
73locomotory exploration behavior (GO:0035641)2.39969538
74signal complex assembly (GO:0007172)2.39609452
75neuronal ion channel clustering (GO:0045161)2.39104883
76protein targeting to plasma membrane (GO:0072661)2.37806372
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.37366321
78entrainment of circadian clock (GO:0009649)2.37174341
79dermatan sulfate metabolic process (GO:0030205)2.36117081
80nuclear envelope reassembly (GO:0031468)2.34720028
81mitotic nuclear envelope reassembly (GO:0007084)2.34720028
82bone trabecula formation (GO:0060346)2.32637811
83embryo implantation (GO:0007566)2.32563794
84actin filament polymerization (GO:0030041)2.32356340
85regulation of ARF protein signal transduction (GO:0032012)2.32241596
86autophagic vacuole assembly (GO:0000045)2.32222070
87virion assembly (GO:0019068)2.31549392
88regulation of synaptic vesicle transport (GO:1902803)2.31290967
89phagocytosis (GO:0006909)2.30547988
90immunoglobulin mediated immune response (GO:0016064)2.30109169
91regulation of synapse structural plasticity (GO:0051823)2.28843727
92regulation of actin nucleation (GO:0051125)2.26609481
93regulation of protein dephosphorylation (GO:0035304)2.22324573
94peptidyl-proline hydroxylation (GO:0019511)2.21299578
95dendritic spine organization (GO:0097061)2.20096078
96negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.19849584
97negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.18379995
98layer formation in cerebral cortex (GO:0021819)2.18302919
99sodium ion export (GO:0071436)2.17697653
100endoplasmic reticulum unfolded protein response (GO:0030968)2.17675882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse4.11561500
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.00875246
3LXR_22292898_ChIP-Seq_THP-1_Human2.93003913
4MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.86396996
5RARG_19884340_ChIP-ChIP_MEFs_Mouse2.80310359
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.55176487
7VDR_21846776_ChIP-Seq_THP-1_Human2.49888944
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.41949092
9CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.36019819
10TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.28715805
11KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18157622
12EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12467633
13* P68_20966046_ChIP-Seq_HELA_Human1.93602166
14TET1_21451524_ChIP-Seq_MESCs_Mouse1.92048781
15KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90370464
16SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.86443084
17KDM2B_26808549_Chip-Seq_DND41_Human1.84342652
18RACK7_27058665_Chip-Seq_MCF-7_Human1.83802995
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.82278294
20ERG_21242973_ChIP-ChIP_JURKAT_Human1.82214959
21DNAJC2_21179169_ChIP-ChIP_NT2_Human1.76210522
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.75778867
23CTCF_27219007_Chip-Seq_ERYTHROID_Human1.74577535
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.74243258
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.70737116
26EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.69069171
27CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65755355
28SMC4_20622854_ChIP-Seq_HELA_Human1.65726499
29SA1_27219007_Chip-Seq_ERYTHROID_Human1.64452913
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.63620701
31MYC_22102868_ChIP-Seq_BL_Human1.60147485
32ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59648894
33* BCL6_27268052_Chip-Seq_Bcells_Human1.59123574
34TCF7_22412390_ChIP-Seq_EML_Mouse1.58430408
35UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.55201553
36CLOCK_20551151_ChIP-Seq_293T_Human1.52577914
37KDM2B_26808549_Chip-Seq_K562_Human1.48600710
38SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.46595213
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.46376224
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.46362393
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45135402
42HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44193245
43* BCOR_27268052_Chip-Seq_Bcells_Human1.42692203
44SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41602072
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.40557953
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.38989847
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35288262
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34408654
49SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33573976
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32532742
51RUNX1_22412390_ChIP-Seq_EML_Mouse1.32269864
52MAF_26560356_Chip-Seq_TH2_Human1.32245374
53SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.32041625
54CREB1_26743006_Chip-Seq_LNCaP_Human1.31787099
55PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30425831
56ZNF263_19887448_ChIP-Seq_K562_Human1.30125964
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27922363
58CTCF_26484167_Chip-Seq_Bcells_Mouse1.26987972
59* PHF8_20622854_ChIP-Seq_HELA_Human1.25745688
60CTCF_27219007_Chip-Seq_Bcells_Human1.24158143
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24118362
62TET1_21490601_ChIP-Seq_MESCs_Mouse1.23677580
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23146789
64RARB_24833708_ChIP-Seq_LIVER_Mouse1.22681178
65RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22391877
66NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.21905036
67TP53_22127205_ChIP-Seq_IMR90_Human1.20988928
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.20668497
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.20097513
70E2F1_20622854_ChIP-Seq_HELA_Human1.18261083
71CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17536776
72RARA_24833708_ChIP-Seq_LIVER_Mouse1.17254164
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.17039505
74CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14837293
75CTCF_20526341_ChIP-Seq_ESCs_Human1.14531644
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11746173
77VDR_24763502_ChIP-Seq_THP-1_Human1.11650946
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10469104
79PU.1_20513432_ChIP-Seq_Bcells_Mouse1.09864159
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.08175103
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.06712177
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.06443002
83MAF_26560356_Chip-Seq_TH1_Human1.06324876
84SA1_27219007_Chip-Seq_Bcells_Human1.06104263
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.05761498
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05546706
87CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05350566
88NCOR1_26117541_ChIP-Seq_K562_Human1.04177033
89UTX_26944678_Chip-Seq_JUKART_Human1.04063759
90ETS1_21867929_ChIP-Seq_TH2_Mouse1.03236425
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02948927
92TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.02097279
93YY1_22570637_ChIP-Seq_MALME-3M_Human1.01695023
94CTCF_21964334_Chip-Seq_Bcells_Human1.01620739
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01546505
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01320723
97TP63_22573176_ChIP-Seq_HFKS_Human1.01053170
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.01034524
99MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.00557308
100P300_27058665_Chip-Seq_ZR-75-30cells_Human0.98444530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.91545908
2MP0008260_abnormal_autophagy3.87932162
3MP0003172_abnormal_lysosome_physiology3.37192399
4MP0004859_abnormal_synaptic_plasticity3.30367860
5MP0001849_ear_inflammation3.13479519
6MP0003705_abnormal_hypodermis_morpholog3.04962653
7MP0008438_abnormal_cutaneous_collagen2.78040298
8MP0000003_abnormal_adipose_tissue2.65228946
9MP0003329_amyloid_beta_deposits2.55141493
10MP0009278_abnormal_bone_marrow2.38371457
11MP0003279_aneurysm2.32799864
12MP0003436_decreased_susceptibility_to2.32043102
13MP0000013_abnormal_adipose_tissue2.24446388
14MP0005503_abnormal_tendon_morphology2.21887060
15MP0001958_emphysema2.21347963
16MP0000751_myopathy2.10787398
17MP0009384_cardiac_valve_regurgitation2.01701594
18MP0005375_adipose_tissue_phenotype1.91715161
19MP0003690_abnormal_glial_cell1.85064623
20MP0004858_abnormal_nervous_system1.81375918
21MP0005666_abnormal_adipose_tissue1.80591055
22MP0005360_urolithiasis1.80131576
23MP0003191_abnormal_cellular_cholesterol1.73059499
24MP0005670_abnormal_white_adipose1.62247876
25MP0001502_abnormal_circadian_rhythm1.49170134
26MP0009840_abnormal_foam_cell1.47050280
27MP0000604_amyloidosis1.38364710
28MP0002933_joint_inflammation1.31736184
29MP0000767_abnormal_smooth_muscle1.30020448
30MP0002249_abnormal_larynx_morphology1.29513790
31MP0004510_myositis1.23676933
32MP0002822_catalepsy1.20678515
33MP0003879_abnormal_hair_cell1.18535424
34MP0003880_abnormal_central_pattern1.18397797
35MP0003303_peritoneal_inflammation1.16827362
36MP0000858_altered_metastatic_potential1.16646518
37MP0004270_analgesia1.16102257
38MP0002998_abnormal_bone_remodeling1.16021523
39MP0003635_abnormal_synaptic_transmissio1.15165397
40MP0010030_abnormal_orbit_morphology1.12398151
41MP0000747_muscle_weakness1.11534009
42MP0001533_abnormal_skeleton_physiology1.07605891
43MP0005023_abnormal_wound_healing1.07505984
44MP0001542_abnormal_bone_strength1.05943027
45MP0002063_abnormal_learning/memory/cond1.03918070
46MP0003566_abnormal_cell_adhesion1.03858672
47MP0003183_abnormal_peptide_metabolism1.03270261
48MP0004947_skin_inflammation1.03024143
49MP0001853_heart_inflammation1.01575831
50MP0003075_altered_response_to1.00619704
51MP0002419_abnormal_innate_immunity1.00464013
52MP0008874_decreased_physiological_sensi1.00058641
53MP0005451_abnormal_body_composition0.97704647
54MP0005409_darkened_coat_color0.97146429
55MP0006054_spinal_hemorrhage0.97137450
56MP0003091_abnormal_cell_migration0.96535727
57MP0008569_lethality_at_weaning0.96103202
58MP0005365_abnormal_bile_salt0.96100488
59MP0000343_altered_response_to0.92797154
60MP0002971_abnormal_brown_adipose0.92416752
61MP0005464_abnormal_platelet_physiology0.92346916
62MP0005508_abnormal_skeleton_morphology0.92248421
63MP0001243_abnormal_dermal_layer0.92248042
64MP0005390_skeleton_phenotype0.92185645
65MP0005535_abnormal_body_temperature0.90118064
66MP0002970_abnormal_white_adipose0.87135422
67MP0001545_abnormal_hematopoietic_system0.87120399
68MP0005397_hematopoietic_system_phenotyp0.87120399
69MP0000750_abnormal_muscle_regeneration0.86209497
70MP0003634_abnormal_glial_cell0.85257905
71MP0003795_abnormal_bone_structure0.85115754
72MP0006036_abnormal_mitochondrial_physio0.85037224
73MP0000681_abnormal_thyroid_gland0.83023487
74MP0005584_abnormal_enzyme/coenzyme_acti0.81727758
75MP0000920_abnormal_myelination0.81708909
76MP0004185_abnormal_adipocyte_glucose0.80627986
77MP0004272_abnormal_basement_membrane0.80084591
78MP0002060_abnormal_skin_morphology0.79673681
79MP0000678_abnormal_parathyroid_gland0.76587765
80MP0001299_abnormal_eye_distance/0.73236455
81MP0005423_abnormal_somatic_nervous0.72808659
82MP0006138_congestive_heart_failure0.72693721
83MP0000759_abnormal_skeletal_muscle0.70950969
84MP0001348_abnormal_lacrimal_gland0.70028084
85MP0005076_abnormal_cell_differentiation0.67674813
86MP0001270_distended_abdomen0.67329391
87MP0003453_abnormal_keratinocyte_physiol0.64025778
88MP0005501_abnormal_skin_physiology0.63751064
89MP0005025_abnormal_response_to0.63238424
90MP0005595_abnormal_vascular_smooth0.61127295
91MP0002132_abnormal_respiratory_system0.59842124
92MP0005166_decreased_susceptibility_to0.59809155
93MP0003724_increased_susceptibility_to0.59348015
94MP0010155_abnormal_intestine_physiology0.57886120
95MP0002064_seizures0.57590139
96MP0009931_abnormal_skin_appearance0.56943425
97MP0005000_abnormal_immune_tolerance0.56338680
98MP0002113_abnormal_skeleton_development0.55572710
99MP0002932_abnormal_joint_morphology0.55367981
100MP0009333_abnormal_splenocyte_physiolog0.54659618

Predicted human phenotypes

RankGene SetZ-score
1Cervical subluxation (HP:0003308)4.54353704
2Biconcave vertebral bodies (HP:0004586)4.04502650
3J-shaped sella turcica (HP:0002680)4.01128257
4Distal upper limb amyotrophy (HP:0007149)3.83562079
5Upper limb amyotrophy (HP:0009129)3.83562079
6Nuclear cataract (HP:0100018)3.71847045
7Dysostosis multiplex (HP:0000943)3.71184877
8Protrusio acetabuli (HP:0003179)3.57370104
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.49023565
10Abnormality of polysaccharide metabolism (HP:0011012)3.49023565
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.49023565
12Hand muscle atrophy (HP:0009130)3.47054990
13Urinary glycosaminoglycan excretion (HP:0003541)3.42391397
14Mucopolysacchariduria (HP:0008155)3.42391397
15Broad face (HP:0000283)3.37677923
16Premature rupture of membranes (HP:0001788)3.32183810
17Supranuclear gaze palsy (HP:0000605)3.27382627
18Joint stiffness (HP:0001387)3.24717800
19Obstructive sleep apnea (HP:0002870)3.20639882
20Neuronal loss in central nervous system (HP:0002529)3.03614832
21Ankle clonus (HP:0011448)2.99479208
22Stridor (HP:0010307)2.94305913
23Vertebral compression fractures (HP:0002953)2.88020249
24Loss of speech (HP:0002371)2.82388730
25Abnormal gallbladder physiology (HP:0012438)2.74758928
26Cholecystitis (HP:0001082)2.74758928
27Thin bony cortex (HP:0002753)2.73457769
28Neurofibrillary tangles (HP:0002185)2.71968558
29Microvesicular hepatic steatosis (HP:0001414)2.61275403
30Distal lower limb amyotrophy (HP:0008944)2.55143520
31Mitral regurgitation (HP:0001653)2.47615649
32Axonal loss (HP:0003447)2.43982718
33Growth hormone excess (HP:0000845)2.43473880
34Difficulty climbing stairs (HP:0003551)2.40426562
35Spinal canal stenosis (HP:0003416)2.37900702
36Metaphyseal cupping (HP:0003021)2.35976426
37Gastrointestinal dysmotility (HP:0002579)2.33251784
38Hypertriglyceridemia (HP:0002155)2.32538473
39Ragged-red muscle fibers (HP:0003200)2.28942012
40Aortic regurgitation (HP:0001659)2.25955260
41Myopathic facies (HP:0002058)2.25316103
42Cerebral aneurysm (HP:0004944)2.23550137
43Hepatosplenomegaly (HP:0001433)2.20592278
44Papilledema (HP:0001085)2.15676620
45Abnormality of dentin (HP:0010299)2.14177693
46Short clavicles (HP:0000894)2.13558168
47Shallow orbits (HP:0000586)2.10642829
48Lymphangioma (HP:0100764)2.10004984
49Bell-shaped thorax (HP:0001591)2.09235337
50Turricephaly (HP:0000262)2.08429766
51Abnormality of glycolipid metabolism (HP:0010969)2.06794693
52Abnormality of liposaccharide metabolism (HP:0010968)2.06794693
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.06794693
54Neurodegeneration (HP:0002180)2.05832112
55Abnormality of lateral ventricle (HP:0030047)2.05698473
56Peripheral hypomyelination (HP:0007182)2.04082578
57Atrophic scars (HP:0001075)2.02074999
58Cerebral inclusion bodies (HP:0100314)2.01792867
59Wormian bones (HP:0002645)2.01776313
60Hyperacusis (HP:0010780)2.01327243
61Increased connective tissue (HP:0009025)2.01015912
62Testicular atrophy (HP:0000029)2.00559293
63Broad metatarsal (HP:0001783)2.00140303
64Aplasia/Hypoplasia of the clavicles (HP:0006710)1.99723748
65Mutism (HP:0002300)1.99342333
66Hemorrhage of the eye (HP:0011885)1.98855201
67Mildly elevated creatine phosphokinase (HP:0008180)1.97852773
68Atelectasis (HP:0100750)1.97319825
69Bladder diverticulum (HP:0000015)1.94200754
70Prolonged neonatal jaundice (HP:0006579)1.93851896
71Polygenic inheritance (HP:0010982)1.92670676
72Deformed sella turcica (HP:0002681)1.92342270
73Long palpebral fissure (HP:0000637)1.91790445
74Delusions (HP:0000746)1.89210790
75Amyloidosis (HP:0011034)1.85565855
76Rapidly progressive (HP:0003678)1.85342200
77Insomnia (HP:0100785)1.83522633
78Personality changes (HP:0000751)1.82469256
79Malnutrition (HP:0004395)1.81723358
80Interstitial pulmonary disease (HP:0006530)1.78990374
81Distal lower limb muscle weakness (HP:0009053)1.78961245
82Abnormality of the lower motor neuron (HP:0002366)1.78533582
83Aortic valve stenosis (HP:0001650)1.77171708
84Acanthosis nigricans (HP:0000956)1.76915285
85Lower limb amyotrophy (HP:0007210)1.75028879
86Hammertoe (HP:0001765)1.74513527
87Reticulocytosis (HP:0001923)1.74216742
88Upper limb muscle weakness (HP:0003484)1.72663464
89Progressive neurologic deterioration (HP:0002344)1.70838567
90Systemic lupus erythematosus (HP:0002725)1.70668147
91Blue sclerae (HP:0000592)1.70458239
92Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.68883809
93Short nail (HP:0001799)1.68601918
94Distal sensory impairment (HP:0002936)1.66190608
95Dilatation of the ascending aorta (HP:0005111)1.65982739
96Abnormal neuron morphology (HP:0012757)1.65940556
97Abnormality of the motor neurons (HP:0002450)1.65940556
98Asymmetric septal hypertrophy (HP:0001670)1.65872060
99Cerebral palsy (HP:0100021)1.65454485
100Spastic gait (HP:0002064)1.65429312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.47157036
2ERN13.43389364
3TESK13.27867407
4MAP2K32.83234225
5PRKD32.29616195
6MAP3K62.18870926
7PDGFRA2.13250743
8TESK21.91629998
9NTRK11.87392605
10MAP2K61.86343167
11RIPK11.80945910
12MAP3K111.80390444
13TNK21.74560662
14CDK191.71097956
15RIPK41.69773323
16SIK11.66652846
17PAK61.56516286
18SIK21.53851057
19KDR1.48316540
20EPHA41.45885846
21PRPF4B1.39443364
22TBK11.38896565
23NME21.38283669
24EPHB11.37714856
25GRK61.34907050
26MAP2K41.33023445
27PRKD21.32526798
28DAPK21.31657443
29SIK31.31250853
30MARK21.26761682
31PTK21.25729066
32DDR21.23057792
33MAP3K71.11307501
34PKN21.08371199
35BMX1.08165036
36DAPK11.05323241
37LIMK11.02458141
38PDPK11.00770147
39SMG10.99898506
40MAPK120.99535546
41CAMKK10.96753418
42ICK0.96228602
43RPS6KA20.95314537
44UHMK10.94666324
45ARAF0.94157510
46DYRK1A0.92847504
47ZAP700.92571011
48NTRK30.89918786
49FLT30.89908003
50MAP4K10.88783690
51PAK40.88510533
52PIM20.87594305
53TYK20.86813580
54STK380.84828688
55PTK2B0.84492151
56CDC42BPA0.84330924
57JAK30.83767969
58MAP3K130.82280796
59DYRK1B0.80812707
60FGFR40.79407900
61MET0.77280633
62MAP3K30.76908517
63TAOK20.74916931
64MOS0.74732864
65FGR0.71910218
66BLK0.71843434
67PRKG20.71282122
68PDK20.70488913
69CSNK1G30.70476843
70MST1R0.68953028
71FES0.65784283
72NME10.65113172
73PDK10.64817346
74CDK11A0.64050519
75RPS6KC10.62975582
76RPS6KL10.62975582
77LMTK20.62928992
78MAP2K20.62163896
79PTK60.61955556
80GRK50.60165537
81TYRO30.60072153
82BCKDK0.58155273
83CDK150.57136395
84KSR20.54613473
85CSK0.54343338
86CDK140.54253437
87CDK180.52179250
88MUSK0.51903781
89PDGFRB0.51868492
90CSNK1A1L0.51578934
91ABL20.49893981
92PAK10.49044710
93MAPK70.48991614
94PRKD10.48598417
95EPHA20.48485477
96BRSK10.48199034
97SRC0.47882340
98CDK90.44393805
99CDK50.41626997
100DAPK30.40246633

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005114.75202235
2Glycosaminoglycan degradation_Homo sapiens_hsa005313.90346756
3Synaptic vesicle cycle_Homo sapiens_hsa047212.16066984
4Cyanoamino acid metabolism_Homo sapiens_hsa004602.10241302
5Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.00719526
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.96035192
7Sulfur relay system_Homo sapiens_hsa041221.90774014
8Vibrio cholerae infection_Homo sapiens_hsa051101.75341185
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.64279775
10Lysosome_Homo sapiens_hsa041421.63793784
11Fructose and mannose metabolism_Homo sapiens_hsa000511.61605446
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.53523183
13VEGF signaling pathway_Homo sapiens_hsa043701.53276789
14Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51315984
15Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46795280
16GnRH signaling pathway_Homo sapiens_hsa049121.44780632
17Notch signaling pathway_Homo sapiens_hsa043301.44401955
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.43433888
19Shigellosis_Homo sapiens_hsa051311.33198189
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.33050208
21Endocytosis_Homo sapiens_hsa041441.30600244
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20563003
23Salmonella infection_Homo sapiens_hsa051321.19519194
24Phospholipase D signaling pathway_Homo sapiens_hsa040721.18989695
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.14168409
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.12964291
27Leishmaniasis_Homo sapiens_hsa051401.12609668
28Biosynthesis of amino acids_Homo sapiens_hsa012301.11325897
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10568427
30SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09313771
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.09283921
32Galactose metabolism_Homo sapiens_hsa000521.07473911
33Pentose phosphate pathway_Homo sapiens_hsa000301.05777685
34Base excision repair_Homo sapiens_hsa034101.05247952
35Osteoclast differentiation_Homo sapiens_hsa043801.00004601
36Tuberculosis_Homo sapiens_hsa051520.97923620
37Phagosome_Homo sapiens_hsa041450.97355653
38Pertussis_Homo sapiens_hsa051330.97110025
39Prion diseases_Homo sapiens_hsa050200.95700053
40Choline metabolism in cancer_Homo sapiens_hsa052310.94842601
41Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93927108
42Staphylococcus aureus infection_Homo sapiens_hsa051500.86732916
43Viral myocarditis_Homo sapiens_hsa054160.85915741
44Estrogen signaling pathway_Homo sapiens_hsa049150.85788553
45AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83942945
46Toxoplasmosis_Homo sapiens_hsa051450.83674875
47Long-term potentiation_Homo sapiens_hsa047200.83098273
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82963115
49AMPK signaling pathway_Homo sapiens_hsa041520.80720541
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.79909987
51Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79336620
52Central carbon metabolism in cancer_Homo sapiens_hsa052300.77877344
53Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75448889
54Acute myeloid leukemia_Homo sapiens_hsa052210.73549059
55Glioma_Homo sapiens_hsa052140.71944161
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.71127315
57Focal adhesion_Homo sapiens_hsa045100.70226154
58Insulin signaling pathway_Homo sapiens_hsa049100.69499499
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.67402269
60Cocaine addiction_Homo sapiens_hsa050300.66247563
61Rap1 signaling pathway_Homo sapiens_hsa040150.65208909
62Autoimmune thyroid disease_Homo sapiens_hsa053200.64958495
63mTOR signaling pathway_Homo sapiens_hsa041500.63719253
64Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63677927
65Regulation of autophagy_Homo sapiens_hsa041400.63298683
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62935099
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62173863
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61744765
69Amphetamine addiction_Homo sapiens_hsa050310.60071305
70Allograft rejection_Homo sapiens_hsa053300.58788671
71Collecting duct acid secretion_Homo sapiens_hsa049660.58716068
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58255444
73Gastric acid secretion_Homo sapiens_hsa049710.58102546
74Platelet activation_Homo sapiens_hsa046110.58037296
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57179969
76ABC transporters_Homo sapiens_hsa020100.55624332
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55570697
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55529968
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55480075
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54536476
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54165040
82PPAR signaling pathway_Homo sapiens_hsa033200.54149172
83Carbon metabolism_Homo sapiens_hsa012000.52087377
84Dopaminergic synapse_Homo sapiens_hsa047280.51766024
85Amoebiasis_Homo sapiens_hsa051460.51277609
86Chronic myeloid leukemia_Homo sapiens_hsa052200.51027850
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.51023073
88Axon guidance_Homo sapiens_hsa043600.50682215
89Glucagon signaling pathway_Homo sapiens_hsa049220.49952508
90ECM-receptor interaction_Homo sapiens_hsa045120.49723569
91Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49492768
92Prolactin signaling pathway_Homo sapiens_hsa049170.48548656
93Asthma_Homo sapiens_hsa053100.48339614
94TNF signaling pathway_Homo sapiens_hsa046680.48127820
95Arginine biosynthesis_Homo sapiens_hsa002200.48016517
96Rheumatoid arthritis_Homo sapiens_hsa053230.43978586
97Bladder cancer_Homo sapiens_hsa052190.43740801
98Graft-versus-host disease_Homo sapiens_hsa053320.43084574
99Influenza A_Homo sapiens_hsa051640.43037033
100ErbB signaling pathway_Homo sapiens_hsa040120.42705612

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