FAM157A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.86387840
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.59634065
3negative regulation of cell killing (GO:0031342)6.59634065
4positive regulation by symbiont of host defense response (GO:0052509)6.32511996
5modulation by symbiont of host defense response (GO:0052031)6.32511996
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.32511996
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.32511996
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.32511996
9modulation by symbiont of host immune response (GO:0052553)6.32511996
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.75284125
11neutrophil activation involved in immune response (GO:0002283)5.63949188
12antigen processing and presentation of endogenous antigen (GO:0019883)5.49328094
13positive regulation of gamma-delta T cell activation (GO:0046645)5.46985810
14detection of other organism (GO:0098543)5.43384803
15leukocyte migration involved in inflammatory response (GO:0002523)5.31600440
16detection of bacterium (GO:0016045)5.27909218
17macrophage activation involved in immune response (GO:0002281)5.23462612
18leukocyte aggregation (GO:0070486)5.17250376
19antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.11122515
20response to peptidoglycan (GO:0032494)4.82660594
21regulation of B cell receptor signaling pathway (GO:0050855)4.76085379
22detection of external biotic stimulus (GO:0098581)4.72946652
23neutrophil activation (GO:0042119)4.63709022
24detection of molecule of bacterial origin (GO:0032490)4.60875030
25cellular extravasation (GO:0045123)4.60402390
26negative regulation of lymphocyte mediated immunity (GO:0002707)4.58788259
27respiratory burst (GO:0045730)4.50179415
28response to interleukin-15 (GO:0070672)4.47473762
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.37666968
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)4.36984717
31regulation of interferon-beta biosynthetic process (GO:0045357)4.36408561
32negative regulation of interleukin-12 production (GO:0032695)4.35054950
33response to host immune response (GO:0052572)4.22060018
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.22060018
35positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.15799588
36regulation of gamma-delta T cell activation (GO:0046643)4.13880204
37detection of biotic stimulus (GO:0009595)4.11718099
38granulocyte activation (GO:0036230)4.11096697
39negative regulation of leukocyte mediated immunity (GO:0002704)3.98704731
40cellular response to interleukin-15 (GO:0071350)3.96461235
41neutrophil mediated immunity (GO:0002446)3.93047587
42regulation of mast cell degranulation (GO:0043304)3.91481530
43microglial cell activation (GO:0001774)3.89685723
44response to host (GO:0075136)3.86947215
45response to host defenses (GO:0052200)3.86947215
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.86947215
47myeloid cell activation involved in immune response (GO:0002275)3.86395142
48immunoglobulin mediated immune response (GO:0016064)3.81187751
49regulation of T-helper 2 cell differentiation (GO:0045628)3.80386522
50macrophage activation (GO:0042116)3.79294352
51production of molecular mediator involved in inflammatory response (GO:0002532)3.77647758
52negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.77124207
53regulation of myeloid leukocyte mediated immunity (GO:0002886)3.71480469
54germinal center formation (GO:0002467)3.65605998
55regulation of gamma-delta T cell differentiation (GO:0045586)3.62308619
56regulation of mast cell activation involved in immune response (GO:0033006)3.61401588
57negative regulation of phagocytosis (GO:0050765)3.58856456
58negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.57553211
59negative regulation of T-helper cell differentiation (GO:0045623)3.57553211
60leukocyte degranulation (GO:0043299)3.55875191
61negative regulation of T cell mediated immunity (GO:0002710)3.51839095
62regulation of leukocyte degranulation (GO:0043300)3.42613370
63myeloid leukocyte mediated immunity (GO:0002444)3.37696951
64cellular response to type I interferon (GO:0071357)3.35233251
65type I interferon signaling pathway (GO:0060337)3.35233251
66response to type I interferon (GO:0034340)3.34640275
67defense response to protozoan (GO:0042832)3.33348319
68response to muramyl dipeptide (GO:0032495)3.33087490
69antigen processing and presentation via MHC class Ib (GO:0002475)3.32566449
70regulation of mast cell activation (GO:0033003)3.30772479
71positive regulation of mast cell activation (GO:0033005)3.30397556
72B cell receptor signaling pathway (GO:0050853)3.22627165
73negative regulation of erythrocyte differentiation (GO:0045647)3.19651137
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.16803824
75negative regulation of alpha-beta T cell activation (GO:0046636)3.15340405
76regulation of T cell tolerance induction (GO:0002664)3.14534647
77regulation of B cell differentiation (GO:0045577)3.13987327
78positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.13022038
79negative regulation of interleukin-6 production (GO:0032715)3.12515307
80regulation of T cell mediated cytotoxicity (GO:0001914)3.11604384
81regulation of tolerance induction (GO:0002643)3.09892461
82regulation of regulated secretory pathway (GO:1903305)3.07333760
83neutrophil chemotaxis (GO:0030593)3.06103569
84negative regulation of cytokine production involved in immune response (GO:0002719)3.04021499
85negative regulation of type 2 immune response (GO:0002829)3.02299348
86regulation of dendritic cell antigen processing and presentation (GO:0002604)2.98931297
87neutrophil migration (GO:1990266)2.98211686
88B cell mediated immunity (GO:0019724)2.96467295
89tolerance induction (GO:0002507)2.95800892
90dendritic cell migration (GO:0036336)2.95473924
91negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.94714938
92positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92530265
93regulation of natural killer cell mediated immunity (GO:0002715)2.92197555
94regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.92197555
95dendritic cell chemotaxis (GO:0002407)2.91125130
96negative regulation of innate immune response (GO:0045824)2.89931211
97lipopolysaccharide-mediated signaling pathway (GO:0031663)2.89670773
98interferon-gamma-mediated signaling pathway (GO:0060333)2.88403711
99myeloid leukocyte activation (GO:0002274)2.88250326
100positive regulation of B cell differentiation (GO:0045579)2.88212077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.47352661
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.47276211
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.70233793
4MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.51233728
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.29812692
6VDR_21846776_ChIP-Seq_THP-1_Human2.94476482
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.80836281
8* SPI1_23127762_ChIP-Seq_K562_Human2.74653751
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.74405345
10VDR_24763502_ChIP-Seq_THP-1_Human2.68060104
11SPI1_23547873_ChIP-Seq_NB4_Human2.61453049
12RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.54138879
13RUNX_20019798_ChIP-Seq_JUKART_Human2.51906277
14MAF_26560356_Chip-Seq_TH1_Human2.46822629
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.41344029
16* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.37988472
17MYC_22102868_ChIP-Seq_BL_Human2.31935040
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31242145
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.30104398
20UTX_26944678_Chip-Seq_JUKART_Human2.27829156
21RUNX1_22412390_ChIP-Seq_EML_Mouse2.27603826
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27388943
23TCF7_22412390_ChIP-Seq_EML_Mouse2.26283454
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21754046
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20719839
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.20430127
27SCL_19346495_ChIP-Seq_HPC-7_Human2.15939575
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.15250912
29MYB_26560356_Chip-Seq_TH2_Human2.09351719
30KDM2B_26808549_Chip-Seq_DND41_Human2.05131883
31STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.01743511
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.97953688
33MAF_26560356_Chip-Seq_TH2_Human1.97660957
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.95383808
35MYB_26560356_Chip-Seq_TH1_Human1.94317579
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94234022
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.93029557
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91750606
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.91137963
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88058536
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.84446637
42KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.73332463
43LXR_22292898_ChIP-Seq_THP-1_Human1.72821476
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.65578962
45GATA3_27048872_Chip-Seq_THYMUS_Human1.61229257
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.60673045
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.60265093
48ELK3_25401928_ChIP-Seq_HUVEC_Human1.57413760
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53697429
50VDR_24787735_ChIP-Seq_THP-1_Human1.52455730
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50024755
52BCL6_27268052_Chip-Seq_Bcells_Human1.47681292
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.45293463
54VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.43091631
55PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42176330
56BCOR_27268052_Chip-Seq_Bcells_Human1.39502828
57KDM2B_26808549_Chip-Seq_JURKAT_Human1.38972431
58NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38220164
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38005281
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.37689021
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.36391944
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35345958
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33246714
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.31429161
65GATA1_19941826_ChIP-Seq_K562_Human1.30613722
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29887859
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.28960233
68GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27370074
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26759605
70GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26748905
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26473882
72PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25708420
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.25423163
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24879059
75SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23813234
76CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23582260
77P68_20966046_ChIP-Seq_HELA_Human1.18670485
78PU.1_20513432_ChIP-Seq_Bcells_Mouse1.17384357
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17328011
80GATA3_26560356_Chip-Seq_TH2_Human1.14594500
81NCOR1_26117541_ChIP-Seq_K562_Human1.14513076
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14193773
83SA1_27219007_Chip-Seq_ERYTHROID_Human1.14155024
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10990546
85ELF1_20517297_ChIP-Seq_JURKAT_Human1.10827590
86SMAD_19615063_ChIP-ChIP_OVARY_Human1.10513608
87SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10343503
88KDM2B_26808549_Chip-Seq_K562_Human1.07868933
89PU_27001747_Chip-Seq_BMDM_Mouse1.06915647
90RACK7_27058665_Chip-Seq_MCF-7_Human1.06861886
91SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05394710
92SMC4_20622854_ChIP-Seq_HELA_Human1.04246780
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02241423
94SPI1_20517297_ChIP-Seq_HL60_Human1.01675157
95RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99823016
96GATA2_19941826_ChIP-Seq_K562_Human0.98502512
97E2F1_20622854_ChIP-Seq_HELA_Human0.98333258
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97824089
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.95577433
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94972834

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.28308748
2MP0003436_decreased_susceptibility_to4.62541899
3MP0003303_peritoneal_inflammation3.80347714
4MP0001835_abnormal_antigen_presentation3.39233931
5MP0002419_abnormal_innate_immunity3.31079079
6MP0005025_abnormal_response_to2.95906938
7MP0001790_abnormal_immune_system2.84945677
8MP0005387_immune_system_phenotype2.84945677
9MP0001800_abnormal_humoral_immune2.83801537
10MP0000685_abnormal_immune_system2.75141812
11MP0009785_altered_susceptibility_to2.70974819
12MP0005000_abnormal_immune_tolerance2.66818814
13MP0002132_abnormal_respiratory_system2.66164281
14MP0005671_abnormal_response_to2.63610827
15MP0002723_abnormal_immune_serum2.57512211
16MP0002420_abnormal_adaptive_immunity2.54232248
17MP0001819_abnormal_immune_cell2.51910730
18MP0002452_abnormal_antigen_presenting2.40796593
19MP0006082_CNS_inflammation2.38698766
20MP0003300_gastrointestinal_ulcer2.33309754
21MP0001533_abnormal_skeleton_physiology2.24569531
22MP0008260_abnormal_autophagy2.19511095
23MP0003191_abnormal_cellular_cholesterol2.17795888
24MP0002396_abnormal_hematopoietic_system2.09835429
25MP0009278_abnormal_bone_marrow2.07403757
26MP0002405_respiratory_system_inflammati2.06259170
27MP0003763_abnormal_thymus_physiology1.96280059
28MP0002398_abnormal_bone_marrow1.93814191
29MP0002148_abnormal_hypersensitivity_rea1.92055686
30MP0000716_abnormal_immune_system1.87954920
31MP0005464_abnormal_platelet_physiology1.87583966
32MP0002277_abnormal_respiratory_mucosa1.76241110
33MP0003828_pulmonary_edema1.72421350
34MP0010155_abnormal_intestine_physiology1.71217207
35MP0003172_abnormal_lysosome_physiology1.71206332
36MP0005451_abnormal_body_composition1.67661504
37MP0004381_abnormal_hair_follicle1.66807982
38MP0003866_abnormal_defecation1.66378183
39MP0001845_abnormal_inflammatory_respons1.65910253
40MP0003183_abnormal_peptide_metabolism1.64551661
41MP0005377_hearing/vestibular/ear_phenot1.63777640
42MP0003878_abnormal_ear_physiology1.63777640
43MP0004947_skin_inflammation1.61329041
44MP0002722_abnormal_immune_system1.60761548
45MP0000689_abnormal_spleen_morphology1.55398186
46MP0000703_abnormal_thymus_morphology1.53767293
47MP0004510_myositis1.49647013
48MP0002429_abnormal_blood_cell1.48499176
49MP0000465_gastrointestinal_hemorrhage1.47424733
50MP0005310_abnormal_salivary_gland1.45675596
51MP0008469_abnormal_protein_level1.41620076
52MP0009333_abnormal_splenocyte_physiolog1.39991292
53MP0009764_decreased_sensitivity_to1.38643109
54MP0005397_hematopoietic_system_phenotyp1.36344689
55MP0001545_abnormal_hematopoietic_system1.36344689
56MP0004883_abnormal_blood_vessel1.32895696
57MP0001851_eye_inflammation1.29539159
58MP0000858_altered_metastatic_potential1.18478011
59MP0002998_abnormal_bone_remodeling1.13467830
60MP0003075_altered_response_to1.04665174
61MP0005164_abnormal_response_to1.01872010
62MP0008004_abnormal_stomach_pH0.99558924
63MP0001986_abnormal_taste_sensitivity0.97388417
64MP0003690_abnormal_glial_cell0.91843629
65MP0001873_stomach_inflammation0.90992880
66MP0005390_skeleton_phenotype0.89949351
67MP0001663_abnormal_digestive_system0.85615546
68MP0005083_abnormal_biliary_tract0.84473275
69MP0004808_abnormal_hematopoietic_stem0.82604157
70MP0003045_fibrosis0.81019637
71MP0005166_decreased_susceptibility_to0.80812105
72MP0004858_abnormal_nervous_system0.79424875
73MP0000490_abnormal_crypts_of0.79322984
74MP0005248_abnormal_Harderian_gland0.77510979
75MP0000678_abnormal_parathyroid_gland0.74889663
76MP0005076_abnormal_cell_differentiation0.72661861
77MP0009763_increased_sensitivity_to0.69500684
78MP0005075_abnormal_melanosome_morpholog0.66668750
79MP0002928_abnormal_bile_duct0.66420333
80MP0003806_abnormal_nucleotide_metabolis0.64440193
81MP0009765_abnormal_xenobiotic_induced0.63548074
82MP0003448_altered_tumor_morphology0.63147776
83MP0002933_joint_inflammation0.61891299
84MP0002166_altered_tumor_susceptibility0.60757857
85MP0003795_abnormal_bone_structure0.60251237
86MP0003656_abnormal_erythrocyte_physiolo0.60250639
87MP0002653_abnormal_ependyma_morphology0.59824567
88MP0005410_abnormal_fertilization0.59247330
89MP0000015_abnormal_ear_pigmentation0.58845827
90MP0008874_decreased_physiological_sensi0.58569865
91MP0005319_abnormal_enzyme/_coenzyme0.57130581
92MP0002138_abnormal_hepatobiliary_system0.57127199
93MP0000343_altered_response_to0.55868394
94MP0000470_abnormal_stomach_morphology0.54628195
95MP0005058_abnormal_lysosome_morphology0.54305939
96MP0003705_abnormal_hypodermis_morpholog0.53295681
97MP0003221_abnormal_cardiomyocyte_apopto0.52789645
98MP0000249_abnormal_blood_vessel0.51597214
99MP0002693_abnormal_pancreas_physiology0.51493617
100MP0004130_abnormal_muscle_cell0.48008346

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)7.13168785
2Myositis (HP:0100614)6.32417716
3Recurrent abscess formation (HP:0002722)6.22913512
4Recurrent bacterial skin infections (HP:0005406)6.01152677
5Orchitis (HP:0100796)5.98654933
6Abnormality of macrophages (HP:0004311)5.58852089
7Retrobulbar optic neuritis (HP:0100654)5.51179365
8Optic neuritis (HP:0100653)5.51179365
9Recurrent gram-negative bacterial infections (HP:0005420)5.25084001
10Stomatitis (HP:0010280)5.21086534
11Elevated erythrocyte sedimentation rate (HP:0003565)4.81296935
12Hypochromic microcytic anemia (HP:0004840)4.68817151
13Gastrointestinal infarctions (HP:0005244)4.65801251
14Obstructive lung disease (HP:0006536)4.54899415
15Chronic obstructive pulmonary disease (HP:0006510)4.54899415
16Abnormal delayed hypersensitivity skin test (HP:0002963)4.25346116
17Recurrent fungal infections (HP:0002841)4.24471354
18Increased IgE level (HP:0003212)4.20420296
19Mediastinal lymphadenopathy (HP:0100721)4.19684718
20Meningitis (HP:0001287)4.08087314
21Keratoconjunctivitis sicca (HP:0001097)4.01892931
22Hypochromic anemia (HP:0001931)3.99339883
23Recurrent skin infections (HP:0001581)3.96193454
24Gingivitis (HP:0000230)3.85172251
25Encephalitis (HP:0002383)3.80540705
26Keratoconjunctivitis (HP:0001096)3.72195613
27Spontaneous hematomas (HP:0007420)3.71259539
28Prolonged bleeding time (HP:0003010)3.64101331
29Urticaria (HP:0001025)3.59595605
30Chronic mucocutaneous candidiasis (HP:0002728)3.56318780
31Recurrent cutaneous fungal infections (HP:0011370)3.56318780
32Episodic fever (HP:0001954)3.53571811
33Peritonitis (HP:0002586)3.38684001
34Vasculitis (HP:0002633)3.36405724
35Chest pain (HP:0100749)3.33506267
36Cellulitis (HP:0100658)3.28660441
37Anorexia (HP:0002039)3.03942283
38Hemoptysis (HP:0002105)3.02384539
39Inflammation of the large intestine (HP:0002037)2.87861483
40Gastrointestinal inflammation (HP:0004386)2.82585963
41Metaphyseal cupping (HP:0003021)2.78162763
42Arterial thrombosis (HP:0004420)2.77871653
43Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.75637850
44Gingival bleeding (HP:0000225)2.75476915
45Leukocytosis (HP:0001974)2.71994933
46Pustule (HP:0200039)2.69984757
47Pulmonary infiltrates (HP:0002113)2.69542818
48Microcytic anemia (HP:0001935)2.68137754
49Pulmonary embolism (HP:0002204)2.66976508
50Epistaxis (HP:0000421)2.65515756
51Panhypogammaglobulinemia (HP:0003139)2.55451153
52Amyloidosis (HP:0011034)2.51360271
53Petechiae (HP:0000967)2.50701859
54Osteomyelitis (HP:0002754)2.48619899
55Abnormality of the peritoneum (HP:0002585)2.47734444
56Granulocytopenia (HP:0001913)2.42954482
57Abnormality of T cells (HP:0002843)2.40451328
58Sepsis (HP:0100806)2.38729032
59T lymphocytopenia (HP:0005403)2.36609494
60Increased IgM level (HP:0003496)2.35271593
61Abnormality of the pleura (HP:0002103)2.33039771
62Premature loss of primary teeth (HP:0006323)2.32171198
63Abnormality of T cell number (HP:0011839)2.30765243
64Abnormality of T cell physiology (HP:0011840)2.29575272
65Lymphopenia (HP:0001888)2.26022573
66Recurrent viral infections (HP:0004429)2.22540255
67Gangrene (HP:0100758)2.20249233
68Acne (HP:0001061)2.19531470
69Abnormality of the endocardium (HP:0004306)2.18905744
70Slow saccadic eye movements (HP:0000514)2.17538861
71Abnormality of the heme biosynthetic pathway (HP:0010472)2.17228851
72Colitis (HP:0002583)2.16814953
73Difficulty running (HP:0009046)2.11413731
74Abnormality of cells of the lymphoid lineage (HP:0012140)2.10699095
75Hypergammaglobulinemia (HP:0010702)2.10217560
76Keratitis (HP:0000491)2.09211904
77Nasal polyposis (HP:0100582)2.06876226
78Hepatosplenomegaly (HP:0001433)2.05046568
79Glomerulopathy (HP:0100820)2.04387414
80Skin ulcer (HP:0200042)2.02114403
81Acute hepatic failure (HP:0006554)2.00258282
82Segmental peripheral demyelination/remyelination (HP:0003481)1.98794133
83Abnormal platelet volume (HP:0011876)1.98094161
84Abnormality of the pericardium (HP:0001697)1.97314479
85Recurrent pneumonia (HP:0006532)1.96635815
86Cheilitis (HP:0100825)1.95783355
87Abnormality of the fingertips (HP:0001211)1.94312034
88Vertigo (HP:0002321)1.93678249
89Polycythemia (HP:0001901)1.92477008
90Toxemia of pregnancy (HP:0100603)1.89515237
91Increased serum ferritin (HP:0003281)1.87752761
92Purpura (HP:0000979)1.86812656
93Abnormality of iron homeostasis (HP:0011031)1.86407071
94Chronic otitis media (HP:0000389)1.84107940
95Hypermelanotic macule (HP:0001034)1.80787072
96Eosinophilia (HP:0001880)1.78312123
97IgM deficiency (HP:0002850)1.77536266
98Recurrent lower respiratory tract infections (HP:0002783)1.73739669
99Recurrent sinusitis (HP:0011108)1.72843361
100Skin rash (HP:0000988)1.68653551

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.95962319
2IRAK43.51266358
3MAP4K13.49303496
4ERN13.37618510
5MAP2K33.12054910
6TNK23.02019719
7BLK2.92466241
8CSK2.61920288
9TYK22.59970701
10EPHB12.57299324
11GRK62.37788634
12FES2.32808434
13TAOK12.19010230
14ZAP701.95456982
15MAP3K31.85977573
16MAP3K111.84884575
17HCK1.82119911
18BTK1.75139714
19FGR1.72693803
20JAK31.64959584
21PRPF4B1.57926672
22KSR21.56172350
23TXK1.51056858
24SIK31.49525244
25JAK21.40579721
26MARK21.39164310
27SYK1.38406542
28TRIB31.37428828
29MAP3K11.35526641
30SIK21.34410148
31PTK61.29099186
32YES11.22881964
33PRKD21.21554488
34LYN1.20878070
35IKBKE1.18546648
36MARK31.10232641
37MAP3K131.08475454
38LCK1.04725238
39TBK11.04274324
40CDK191.03796261
41STK381.03668360
42IRAK11.02175736
43MAP3K71.01048001
44SMG10.99815394
45CSF1R0.99447908
46MAP3K60.97773986
47PDK10.97665000
48SIK10.96902440
49PTK2B0.96882150
50MAP3K140.95426938
51JAK10.93563728
52TAOK30.93488384
53PDPK10.91334962
54IRAK20.88671199
55ITK0.82966622
56KIT0.82765213
57MAP3K20.81717678
58MATK0.79419080
59MAP2K40.76063626
60STK110.71690222
61TAOK20.71480785
62STK100.69445653
63CDC42BPA0.68338802
64DYRK1B0.67398887
65FYN0.66610692
66FGFR40.64178041
67TESK20.61349401
68TEC0.59191910
69RET0.58698079
70MAP2K60.58583758
71IKBKB0.58442437
72PRKG20.57599467
73EPHA30.53410712
74SGK30.52841194
75MAPK120.52629021
76LRRK20.52047151
77HIPK20.51763836
78RPS6KC10.51123805
79RPS6KL10.51123805
80PKN20.50369777
81CDK120.48270174
82BMX0.48182813
83PRKCZ0.46981602
84DAPK20.46890081
85WNK10.45643800
86FGFR30.44646683
87RPS6KA60.44354769
88RAF10.44335900
89KSR10.41716049
90MAPK70.41520620
91NLK0.41283945
92PRKCQ0.40521870
93MAP3K50.39688596
94BMPR20.36844493
95MAPKAPK20.36819019
96PIK3CG0.35884546
97RPS6KA10.34003521
98ALK0.32931382
99PRKCH0.32898520
100SGK20.32210612

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043803.15944808
2Leishmaniasis_Homo sapiens_hsa051402.88993044
3Staphylococcus aureus infection_Homo sapiens_hsa051502.67515828
4Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.40020290
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.39154388
6B cell receptor signaling pathway_Homo sapiens_hsa046622.26113756
7Tuberculosis_Homo sapiens_hsa051522.11126611
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.09039347
9Acute myeloid leukemia_Homo sapiens_hsa052212.05681631
10Graft-versus-host disease_Homo sapiens_hsa053322.01944563
11Allograft rejection_Homo sapiens_hsa053301.91330706
12Malaria_Homo sapiens_hsa051441.90118220
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90061587
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.88753555
15Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.82900595
16Primary immunodeficiency_Homo sapiens_hsa053401.81894655
17Chemokine signaling pathway_Homo sapiens_hsa040621.79730852
18Autoimmune thyroid disease_Homo sapiens_hsa053201.79197943
19Measles_Homo sapiens_hsa051621.71009730
20T cell receptor signaling pathway_Homo sapiens_hsa046601.55034030
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51168091
22Legionellosis_Homo sapiens_hsa051341.44610451
23Hematopoietic cell lineage_Homo sapiens_hsa046401.43795173
24Influenza A_Homo sapiens_hsa051641.43527451
25African trypanosomiasis_Homo sapiens_hsa051431.43447593
26Type I diabetes mellitus_Homo sapiens_hsa049401.43285842
27Toxoplasmosis_Homo sapiens_hsa051451.41728454
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.41075091
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.39536964
30Antigen processing and presentation_Homo sapiens_hsa046121.38807729
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34673404
32Non-small cell lung cancer_Homo sapiens_hsa052231.34344758
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.33433660
34Viral myocarditis_Homo sapiens_hsa054161.33017351
35Phagosome_Homo sapiens_hsa041451.28981716
36Herpes simplex infection_Homo sapiens_hsa051681.28317913
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.26848170
38TNF signaling pathway_Homo sapiens_hsa046681.21284115
39VEGF signaling pathway_Homo sapiens_hsa043701.20605129
40Platelet activation_Homo sapiens_hsa046111.16888536
41Chronic myeloid leukemia_Homo sapiens_hsa052201.08414069
42Hepatitis C_Homo sapiens_hsa051601.08159272
43Hepatitis B_Homo sapiens_hsa051611.08112002
44Pancreatic cancer_Homo sapiens_hsa052121.04874368
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03105073
46Notch signaling pathway_Homo sapiens_hsa043301.01043892
47Endocytosis_Homo sapiens_hsa041440.96870998
48Shigellosis_Homo sapiens_hsa051310.92949099
49Prolactin signaling pathway_Homo sapiens_hsa049170.91892627
50Carbohydrate digestion and absorption_Homo sapiens_hsa049730.90233979
51Renal cell carcinoma_Homo sapiens_hsa052110.89358203
52Salmonella infection_Homo sapiens_hsa051320.88078356
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.86944125
54Other glycan degradation_Homo sapiens_hsa005110.85027871
55Apoptosis_Homo sapiens_hsa042100.84542369
56Choline metabolism in cancer_Homo sapiens_hsa052310.84327999
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83745745
58Pertussis_Homo sapiens_hsa051330.82836628
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.80996810
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.80288909
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.80114758
62Endometrial cancer_Homo sapiens_hsa052130.78770727
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78142411
64FoxO signaling pathway_Homo sapiens_hsa040680.77467018
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76968858
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.75263922
67Dorso-ventral axis formation_Homo sapiens_hsa043200.74709489
68Regulation of autophagy_Homo sapiens_hsa041400.73998363
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73364989
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72317613
71Type II diabetes mellitus_Homo sapiens_hsa049300.70871374
72Inositol phosphate metabolism_Homo sapiens_hsa005620.68006407
73Intestinal immune network for IgA production_Homo sapiens_hsa046720.66889810
74mTOR signaling pathway_Homo sapiens_hsa041500.66859624
75GnRH signaling pathway_Homo sapiens_hsa049120.66676553
76Viral carcinogenesis_Homo sapiens_hsa052030.66383061
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65868564
78Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64399932
79Epstein-Barr virus infection_Homo sapiens_hsa051690.63230522
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62411192
81Insulin resistance_Homo sapiens_hsa049310.62163108
82Colorectal cancer_Homo sapiens_hsa052100.61702903
83Rap1 signaling pathway_Homo sapiens_hsa040150.61527551
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60456906
85MAPK signaling pathway_Homo sapiens_hsa040100.59052495
86Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58942225
87Amoebiasis_Homo sapiens_hsa051460.57619322
88HIF-1 signaling pathway_Homo sapiens_hsa040660.56959137
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56136069
90ErbB signaling pathway_Homo sapiens_hsa040120.55928253
91Insulin signaling pathway_Homo sapiens_hsa049100.52972302
92HTLV-I infection_Homo sapiens_hsa051660.49606070
93Estrogen signaling pathway_Homo sapiens_hsa049150.48713601
94Rheumatoid arthritis_Homo sapiens_hsa053230.47246132
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46005487
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45935442
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.41882068
98Prostate cancer_Homo sapiens_hsa052150.41166445
99Lysosome_Homo sapiens_hsa041420.40773032
100Asthma_Homo sapiens_hsa053100.39807236

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