FAM159A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sequestering of actin monomers (GO:0042989)5.91071949
2regulation of glucocorticoid secretion (GO:2000849)5.21865631
3regulation of corticosteroid hormone secretion (GO:2000846)5.18115841
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.09265806
5respiratory system process (GO:0003016)4.71187970
6regulation of appetite (GO:0032098)4.69915393
7ATP synthesis coupled proton transport (GO:0015986)4.57651546
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.57651546
9DNA deamination (GO:0045006)4.52908486
10GTP biosynthetic process (GO:0006183)4.52902733
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.31523598
12establishment of protein localization to mitochondrial membrane (GO:0090151)4.29382830
13regulation of chromatin binding (GO:0035561)4.24220806
14behavioral response to nicotine (GO:0035095)4.21010311
15UTP biosynthetic process (GO:0006228)4.08428549
16histone H2B ubiquitination (GO:0033523)4.08002659
17guanosine-containing compound biosynthetic process (GO:1901070)4.03076809
18adult feeding behavior (GO:0008343)3.98353557
19fucose catabolic process (GO:0019317)3.94913038
20L-fucose metabolic process (GO:0042354)3.94913038
21L-fucose catabolic process (GO:0042355)3.94913038
22response to pheromone (GO:0019236)3.92516170
23indole-containing compound catabolic process (GO:0042436)3.91708875
24indolalkylamine catabolic process (GO:0046218)3.91708875
25tryptophan catabolic process (GO:0006569)3.91708875
26regulation of cilium movement (GO:0003352)3.82367269
27proteasome assembly (GO:0043248)3.78982147
28indolalkylamine metabolic process (GO:0006586)3.78313056
29tachykinin receptor signaling pathway (GO:0007217)3.78175884
30CTP metabolic process (GO:0046036)3.77384140
31CTP biosynthetic process (GO:0006241)3.77384140
32axoneme assembly (GO:0035082)3.68300621
33protein insertion into membrane (GO:0051205)3.65245848
34electron transport chain (GO:0022900)3.64431406
35nucleoside diphosphate phosphorylation (GO:0006165)3.60894328
36respiratory electron transport chain (GO:0022904)3.60748730
37regulation of mitochondrial translation (GO:0070129)3.56909467
38histone arginine methylation (GO:0034969)3.56034543
39protein K11-linked deubiquitination (GO:0035871)3.54627689
40pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.49804311
41tryptophan metabolic process (GO:0006568)3.41502220
42regulation of steroid hormone secretion (GO:2000831)3.33637249
43UTP metabolic process (GO:0046051)3.33624075
44detection of light stimulus involved in visual perception (GO:0050908)3.32624823
45detection of light stimulus involved in sensory perception (GO:0050962)3.32624823
46kynurenine metabolic process (GO:0070189)3.29893369
47pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.29851874
48mating behavior (GO:0007617)3.26862885
49RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.26197578
50atrial cardiac muscle cell action potential (GO:0086014)3.23425409
51detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.16129953
52regulation of feeding behavior (GO:0060259)3.13946780
53negative regulation of amino acid transport (GO:0051956)3.13900185
54neuron cell-cell adhesion (GO:0007158)3.13514364
55axonal fasciculation (GO:0007413)3.13484492
56regulation of memory T cell differentiation (GO:0043380)3.12996063
57eating behavior (GO:0042755)3.12171725
58regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10902528
59cullin deneddylation (GO:0010388)3.10349957
60viral transcription (GO:0019083)3.09723284
61ribosomal large subunit biogenesis (GO:0042273)3.08748654
62cilium movement (GO:0003341)3.07641933
63peptidyl-arginine omega-N-methylation (GO:0035247)3.05835383
64rRNA catabolic process (GO:0016075)3.05794356
65protein neddylation (GO:0045116)3.04667295
66forebrain neuron differentiation (GO:0021879)3.04093749
67rhodopsin mediated signaling pathway (GO:0016056)3.02585306
68neuromuscular process controlling posture (GO:0050884)3.02124631
69response to parathyroid hormone (GO:0071107)3.01750334
70positive regulation of defense response to virus by host (GO:0002230)3.00421470
71regulation of rhodopsin mediated signaling pathway (GO:0022400)3.00162062
72sensory perception of smell (GO:0007608)2.97908767
73pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.97364970
74NAD biosynthetic process (GO:0009435)2.96469527
75translational termination (GO:0006415)2.95710356
76negative regulation of calcium ion transport into cytosol (GO:0010523)2.95195028
77regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.94334740
78negative T cell selection (GO:0043383)2.94175130
79piRNA metabolic process (GO:0034587)2.93920714
80regulation of B cell receptor signaling pathway (GO:0050855)2.90870480
81female mating behavior (GO:0060180)2.90854663
82pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.89777724
83neural tube formation (GO:0001841)2.89089437
84regulation of glutamate secretion (GO:0014048)2.84926703
85positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.84311189
86retinal rod cell development (GO:0046548)2.83567831
87negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.83509432
88cellular response to interleukin-15 (GO:0071350)2.83333524
89calcium-mediated signaling using intracellular calcium source (GO:0035584)2.81006550
90peptidyl-arginine methylation (GO:0018216)2.80233971
91peptidyl-arginine N-methylation (GO:0035246)2.80233971
92negative regulation of mast cell activation (GO:0033004)2.77664770
93ribosomal small subunit biogenesis (GO:0042274)2.77644306
94chaperone-mediated protein transport (GO:0072321)2.76664137
95cytidine deamination (GO:0009972)2.76238292
96cytidine metabolic process (GO:0046087)2.76238292
97cytidine catabolic process (GO:0006216)2.76238292
98adaptation of signaling pathway (GO:0023058)2.75478433
99melanosome transport (GO:0032402)2.74920017
100negative regulation of response to food (GO:0032096)2.74202523
101negative regulation of appetite (GO:0032099)2.74202523
102platelet dense granule organization (GO:0060155)2.73805385
103amine catabolic process (GO:0009310)2.73089717
104cellular biogenic amine catabolic process (GO:0042402)2.73089717
105cellular ketone body metabolic process (GO:0046950)2.72962081
106regulation of response to food (GO:0032095)2.71695981
107negative thymic T cell selection (GO:0045060)2.69030126
108maturation of SSU-rRNA (GO:0030490)2.68808412
109auditory receptor cell stereocilium organization (GO:0060088)2.67909916
110indole-containing compound metabolic process (GO:0042430)2.66722075
111purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66456081
112negative regulation of translation, ncRNA-mediated (GO:0040033)2.66384559
113regulation of translation, ncRNA-mediated (GO:0045974)2.66384559
114negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66384559
115regulation of regulatory T cell differentiation (GO:0045589)2.65890269
116multicellular organism reproduction (GO:0032504)2.65511908
117DNA methylation involved in gamete generation (GO:0043046)2.65306106
118SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.65207069
119transcription elongation from RNA polymerase III promoter (GO:0006385)2.65199571
120termination of RNA polymerase III transcription (GO:0006386)2.65199571
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.65109890
122epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.64086170
123mannosylation (GO:0097502)2.63307964
124positive regulation of T cell differentiation in thymus (GO:0033089)2.63033007
125protein targeting to ER (GO:0045047)2.62793662
126cotranslational protein targeting to membrane (GO:0006613)2.62761432
127establishment of melanosome localization (GO:0032401)2.61361892
128protein deneddylation (GO:0000338)2.60789137
129positive regulation of amino acid transport (GO:0051957)2.60293852
130rRNA modification (GO:0000154)2.60226424
131pigment granule transport (GO:0051904)2.59304496
132respiratory chain complex IV assembly (GO:0008535)2.59234863
133negative regulation of telomere maintenance (GO:0032205)2.58911864
134activated T cell proliferation (GO:0050798)2.58553368
135melanin biosynthetic process (GO:0042438)2.57779251
136translational elongation (GO:0006414)2.57541102
137regulation of microtubule-based movement (GO:0060632)2.57496997
138cytochrome complex assembly (GO:0017004)2.57371666
139negative regulation of axon extension involved in axon guidance (GO:0048843)2.57320874
140negative regulation of ligase activity (GO:0051352)2.56770987
141negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.56770987
142purine nucleoside triphosphate biosynthetic process (GO:0009145)2.56677475
143preassembly of GPI anchor in ER membrane (GO:0016254)2.56440474
144regulation of gamma-delta T cell differentiation (GO:0045586)2.56046879
145neurotransmitter catabolic process (GO:0042135)2.55878878
146positive regulation of catecholamine secretion (GO:0033605)2.55437387
147positive regulation of megakaryocyte differentiation (GO:0045654)2.55247242
148ribonucleoside triphosphate biosynthetic process (GO:0009201)2.54171220
149pyrimidine nucleotide biosynthetic process (GO:0006221)2.54062953
150positive regulation of DNA-templated transcription, elongation (GO:0032786)2.53833572
151neuropeptide signaling pathway (GO:0007218)2.53777379
152establishment of protein localization to endoplasmic reticulum (GO:0072599)2.53385788
153cellular protein complex disassembly (GO:0043624)2.53352858
154organelle disassembly (GO:1903008)2.52976639
155pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.52861075
156positive T cell selection (GO:0043368)2.51731290
157pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.51293569
158pyrimidine ribonucleoside catabolic process (GO:0046133)2.51164476
159ribosome assembly (GO:0042255)2.50320833
160regulation of cellular amino acid metabolic process (GO:0006521)2.49500250
161sensory perception of chemical stimulus (GO:0007606)2.49472581
162cornea development in camera-type eye (GO:0061303)2.49353180
163mast cell degranulation (GO:0043303)2.49241956
164mast cell activation involved in immune response (GO:0002279)2.49241956
165positive regulation of gamma-delta T cell activation (GO:0046645)2.49140742
166water-soluble vitamin biosynthetic process (GO:0042364)2.47616454
167ketone body metabolic process (GO:1902224)2.47139082
168reflex (GO:0060004)2.46718626
169regulation of germinal center formation (GO:0002634)2.46016474
170interferon-gamma production (GO:0032609)2.45872707
171photoreceptor cell maintenance (GO:0045494)2.44325512
172regulation of gene silencing by RNA (GO:0060966)2.43869734
173regulation of posttranscriptional gene silencing (GO:0060147)2.43869734
174regulation of gene silencing by miRNA (GO:0060964)2.43869734
175kidney morphogenesis (GO:0060993)2.43843437
176positive regulation of T cell mediated cytotoxicity (GO:0001916)2.42431570
177regulation of defense response to virus by host (GO:0050691)2.41019863
178G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40965728
179regulation of hippo signaling (GO:0035330)2.40925212
180protein polyglutamylation (GO:0018095)2.39452973
181regulation of T cell mediated cytotoxicity (GO:0001914)2.37945355
182establishment of protein localization to Golgi (GO:0072600)2.37545109
183regulation of gamma-delta T cell activation (GO:0046643)2.36922785
184negative regulation of cell killing (GO:0031342)2.36727532
185negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36727532
186positive regulation of granulocyte differentiation (GO:0030854)2.35579032
187cAMP catabolic process (GO:0006198)2.35163201
188response to interleukin-15 (GO:0070672)2.34060635
189antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.33507176
190regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.33347631
191adenosine metabolic process (GO:0046085)2.32638563
192double-strand break repair via homologous recombination (GO:0000724)2.32075448
193recombinational repair (GO:0000725)2.30981145
194proline transport (GO:0015824)2.27838451
195positive regulation of oligodendrocyte differentiation (GO:0048714)2.26874247
196DNA demethylation (GO:0080111)2.25957701
197L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.25270715
198positive regulation of T-helper 1 type immune response (GO:0002827)2.24746231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.92301012
2ZNF274_21170338_ChIP-Seq_K562_Hela3.65351834
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.38306462
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.31052568
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.12893655
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.01033746
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.70371228
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57518069
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.41947865
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.37845112
11CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.33548811
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33319831
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32567902
14GBX2_23144817_ChIP-Seq_PC3_Human2.32153625
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.31752520
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.31491623
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.28637503
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26396032
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.21760922
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19473525
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.18178618
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.15842672
23BMI1_23680149_ChIP-Seq_NPCS_Mouse2.15561735
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.15079137
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.15079137
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.15079137
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.11454546
28GABP_17652178_ChIP-ChIP_JURKAT_Human2.10767170
29POU3F2_20337985_ChIP-ChIP_501MEL_Human2.08957631
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.06147749
31NOTCH1_21737748_ChIP-Seq_TLL_Human2.01671910
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96226015
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92993653
34FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.92653425
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.87666446
36BCAT_22108803_ChIP-Seq_LS180_Human1.84010165
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.83651753
38TAF15_26573619_Chip-Seq_HEK293_Human1.83590266
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83026293
40PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82083404
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.81906905
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.76919557
43CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.76905956
44ZNF263_19887448_ChIP-Seq_K562_Human1.76012280
45ER_23166858_ChIP-Seq_MCF-7_Human1.73739618
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.73411226
47RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71519807
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69064877
49P300_19829295_ChIP-Seq_ESCs_Human1.68644214
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.64684312
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.64163893
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63762122
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62441681
54FUS_26573619_Chip-Seq_HEK293_Human1.60267712
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.59597350
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59401567
57MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56911236
58AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56447727
59* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.56112867
60IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53310343
61GATA3_26560356_Chip-Seq_TH2_Human1.51590476
62STAT3_23295773_ChIP-Seq_U87_Human1.51369275
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51256230
64CBP_20019798_ChIP-Seq_JUKART_Human1.51256230
65EWS_26573619_Chip-Seq_HEK293_Human1.51078997
66REST_21632747_ChIP-Seq_MESCs_Mouse1.50000182
67CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49893336
68TP53_22573176_ChIP-Seq_HFKS_Human1.48817413
69TTF2_22483619_ChIP-Seq_HELA_Human1.48380694
70CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.48245274
71* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46999517
72TCF4_23295773_ChIP-Seq_U87_Human1.46880577
73ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.45033635
74RUNX_20019798_ChIP-Seq_JUKART_Human1.43901406
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43659850
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43112831
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.43076859
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.41673136
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.40265646
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.39651799
81XRN2_22483619_ChIP-Seq_HELA_Human1.39565328
82EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38965910
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.36534618
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.36312598
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35783010
86POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.35783010
87PRDM14_20953172_ChIP-Seq_ESCs_Human1.35243324
88ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35208648
89SOX2_19829295_ChIP-Seq_ESCs_Human1.34274541
90NANOG_19829295_ChIP-Seq_ESCs_Human1.34274541
91POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.33962643
92KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.33857981
93VDR_23849224_ChIP-Seq_CD4+_Human1.33631295
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33303665
95SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32912666
96RNF2_27304074_Chip-Seq_NSC_Mouse1.32870694
97TCF4_22108803_ChIP-Seq_LS180_Human1.31419656
98IGF1R_20145208_ChIP-Seq_DFB_Human1.31378703
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.30119080
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29897729
101POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29843142
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29615307
103AR_25329375_ChIP-Seq_VCAP_Human1.28599243
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27971786
105SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27612936
106SMAD4_21799915_ChIP-Seq_A2780_Human1.27265847
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27178188
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26312008
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26044809
110PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.24544245
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.24321973
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.24321973
113NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23689687
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.23008522
115* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22783789
116EZH2_27294783_Chip-Seq_NPCs_Mouse1.22084476
117EGR1_23403033_ChIP-Seq_LIVER_Mouse1.21274133
118REST_18959480_ChIP-ChIP_MESCs_Mouse1.20374083
119PIAS1_25552417_ChIP-Seq_VCAP_Human1.19577782
120AR_20517297_ChIP-Seq_VCAP_Human1.17867071
121EED_16625203_ChIP-ChIP_MESCs_Mouse1.17613805
122NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16925363
123CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16476721
124TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.16209550
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.15948771
126* GATA3_21878914_ChIP-Seq_MCF-7_Human1.15447399
127GABP_19822575_ChIP-Seq_HepG2_Human1.14915161
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14705333
129ELK1_22589737_ChIP-Seq_MCF10A_Human1.14479669
130* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14405900
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14352339
132JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13546702
133GATA1_26923725_Chip-Seq_HPCs_Mouse1.13544109
134ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13465324
135GATA3_27048872_Chip-Seq_THYMUS_Human1.12761809
136SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12655852
137SMAD4_21741376_ChIP-Seq_EPCs_Human1.11394018
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.11332955
139* MYB_26560356_Chip-Seq_TH2_Human1.10895998
140RUNX2_22187159_ChIP-Seq_PCA_Human1.10791807
141NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.10530473
142PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10499648
143CDX2_22108803_ChIP-Seq_LS180_Human1.09845963
144MYC_18940864_ChIP-ChIP_HL60_Human1.09399503
145HOXB7_26014856_ChIP-Seq_BT474_Human1.09214526
146CRX_20693478_ChIP-Seq_RETINA_Mouse1.09086512
147GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.09014293
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08447594
149KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08376282
150STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08047026
151IRF1_19129219_ChIP-ChIP_H3396_Human1.07706986
152NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07605368
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.06926942
154SMAD3_21741376_ChIP-Seq_EPCs_Human1.03991085
155NCOR_22424771_ChIP-Seq_293T_Human1.03976198
156EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03661260
157RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03661260
158SRF_21415370_ChIP-Seq_HL-1_Mouse1.03240906
159OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02327823
160DROSHA_22980978_ChIP-Seq_HELA_Human1.02082395
161BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01489576
162NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01023117
163RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00788469
164TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00445362
165VDR_22108803_ChIP-Seq_LS180_Human0.99884884
166POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99809622
167JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99475522
168FOXH1_21741376_ChIP-Seq_EPCs_Human0.99170959
169SMRT_27268052_Chip-Seq_Bcells_Human0.98024338
170EZH2_27294783_Chip-Seq_ESCs_Mouse0.97912822
171SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97619972
172TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96891066
173SOX2_16153702_ChIP-ChIP_HESCs_Human0.96058258
174MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93026968
175CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.92588505
176OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90776127
177TP63_19390658_ChIP-ChIP_HaCaT_Human0.90409257
178RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89438910
179CTCF_18555785_ChIP-Seq_MESCs_Mouse0.89128645
180FOXP1_21924763_ChIP-Seq_HESCs_Human0.88568255
181* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88525988
182SUZ12_27294783_Chip-Seq_ESCs_Mouse0.87563534
183SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87246900
184SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.86774557
185ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86661446
186ERA_21632823_ChIP-Seq_H3396_Human0.86270270
187SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.86166157
188DCP1A_22483619_ChIP-Seq_HELA_Human0.85817405
189POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85809614
190PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84886407
191ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84707754
192ERG_21242973_ChIP-ChIP_JURKAT_Human0.84511054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005645_abnormal_hypothalamus_physiol5.74587834
2MP0003122_maternal_imprinting5.47179093
3MP0003121_genomic_imprinting4.46619379
4MP0003123_paternal_imprinting4.21051578
5MP0006276_abnormal_autonomic_nervous3.89245784
6MP0008789_abnormal_olfactory_epithelium3.36656514
7MP0003195_calcinosis3.25368387
8MP0005499_abnormal_olfactory_system3.01803197
9MP0005394_taste/olfaction_phenotype3.01803197
10MP0005671_abnormal_response_to2.96044236
11MP0003646_muscle_fatigue2.94121248
12MP0004133_heterotaxia2.63195396
13MP0001968_abnormal_touch/_nociception2.58313129
14MP0001984_abnormal_olfaction2.40177773
15MP0003787_abnormal_imprinting2.32372022
16MP0005075_abnormal_melanosome_morpholog2.32153030
17MP0000569_abnormal_digit_pigmentation2.30419190
18MP0002638_abnormal_pupillary_reflex2.27537185
19MP0002138_abnormal_hepatobiliary_system2.21941711
20MP0008877_abnormal_DNA_methylation2.20476801
21MP0004043_abnormal_pH_regulation2.12850304
22MP0005551_abnormal_eye_electrophysiolog2.10065157
23MP0001905_abnormal_dopamine_level1.95759120
24MP0002837_dystrophic_cardiac_calcinosis1.94121852
25MP0001440_abnormal_grooming_behavior1.92925637
26MP0003763_abnormal_thymus_physiology1.91938266
27MP0001986_abnormal_taste_sensitivity1.90929288
28MP0002822_catalepsy1.80200162
29MP0002184_abnormal_innervation1.77404166
30MP0002751_abnormal_autonomic_nervous1.76633302
31MP0005423_abnormal_somatic_nervous1.70776733
32MP0001800_abnormal_humoral_immune1.69939401
33MP0003724_increased_susceptibility_to1.65187660
34MP0001835_abnormal_antigen_presentation1.64138037
35MP0001502_abnormal_circadian_rhythm1.63080366
36MP0006082_CNS_inflammation1.55691970
37MP0008995_early_reproductive_senescence1.53334710
38MP0002254_reproductive_system_inflammat1.50934139
39MP0005646_abnormal_pituitary_gland1.50823320
40MP0002734_abnormal_mechanical_nocicepti1.48911660
41MP0000685_abnormal_immune_system1.48858563
42MP0002557_abnormal_social/conspecific_i1.47795899
43MP0002876_abnormal_thyroid_physiology1.46580457
44MP0001188_hyperpigmentation1.46264895
45MP0000778_abnormal_nervous_system1.44772810
46MP0004381_abnormal_hair_follicle1.44542948
47MP0002160_abnormal_reproductive_system1.44239271
48MP0002938_white_spotting1.42598370
49MP0005187_abnormal_penis_morphology1.40220694
50MP0006072_abnormal_retinal_apoptosis1.39716091
51MP0002102_abnormal_ear_morphology1.37124715
52MP0004142_abnormal_muscle_tone1.36755231
53MP0005174_abnormal_tail_pigmentation1.35788096
54MP0002723_abnormal_immune_serum1.35072552
55MP0000751_myopathy1.34224449
56MP0001790_abnormal_immune_system1.34180542
57MP0005387_immune_system_phenotype1.34180542
58MP0001529_abnormal_vocalization1.32924832
59MP0003635_abnormal_synaptic_transmissio1.32005628
60MP0002272_abnormal_nervous_system1.31225094
61MP0003315_abnormal_perineum_morphology1.30562762
62MP0001485_abnormal_pinna_reflex1.29169798
63MP0002928_abnormal_bile_duct1.28867913
64MP0005167_abnormal_blood-brain_barrier1.24332931
65MP0001501_abnormal_sleep_pattern1.22769646
66MP0002572_abnormal_emotion/affect_behav1.22548464
67MP0002452_abnormal_antigen_presenting1.21391716
68MP0005310_abnormal_salivary_gland1.21236414
69MP0000631_abnormal_neuroendocrine_gland1.20652791
70MP0004859_abnormal_synaptic_plasticity1.20015773
71MP0002420_abnormal_adaptive_immunity1.18872894
72MP0000427_abnormal_hair_cycle1.18281351
73MP0002064_seizures1.18062351
74MP0001819_abnormal_immune_cell1.17090204
75MP0006292_abnormal_olfactory_placode1.16698334
76MP0009785_altered_susceptibility_to1.16086728
77MP0002277_abnormal_respiratory_mucosa1.15579733
78MP0002063_abnormal_learning/memory/cond1.15497548
79MP0004270_analgesia1.14462655
80MP0005000_abnormal_immune_tolerance1.14181432
81MP0009745_abnormal_behavioral_response1.13926818
82MP0000537_abnormal_urethra_morphology1.13038987
83MP0003045_fibrosis1.12971951
84MP0004885_abnormal_endolymph1.12822367
85MP0002067_abnormal_sensory_capabilities1.12715885
86MP0002148_abnormal_hypersensitivity_rea1.12383465
87MP0010386_abnormal_urinary_bladder1.12206759
88MP0009046_muscle_twitch1.11722699
89MP0001873_stomach_inflammation1.10002092
90MP0000462_abnormal_digestive_system1.08470970
91MP0003941_abnormal_skin_development1.07159836
92MP0002233_abnormal_nose_morphology1.06644299
93MP0002733_abnormal_thermal_nociception1.06350686
94MP0002693_abnormal_pancreas_physiology1.06306255
95MP0009764_decreased_sensitivity_to1.05747068
96MP0009333_abnormal_splenocyte_physiolog1.05224352
97MP0003011_delayed_dark_adaptation1.03389590
98MP0003786_premature_aging1.03300658
99MP0000015_abnormal_ear_pigmentation1.02074326
100MP0002752_abnormal_somatic_nervous1.01679848
101MP0000516_abnormal_urinary_system1.00611413
102MP0005367_renal/urinary_system_phenotyp1.00611413
103MP0005084_abnormal_gallbladder_morpholo1.00219538
104MP0000383_abnormal_hair_follicle0.99283515
105MP0002736_abnormal_nociception_after0.98791152
106MP0000372_irregular_coat_pigmentation0.98598328
107MP0002882_abnormal_neuron_morphology0.97832466
108MP0001764_abnormal_homeostasis0.97258297
109MP0000689_abnormal_spleen_morphology0.96870441
110MP0004957_abnormal_blastocyst_morpholog0.92414668
111MP0005377_hearing/vestibular/ear_phenot0.91269361
112MP0003878_abnormal_ear_physiology0.91269361
113MP0003119_abnormal_digestive_system0.91186825
114MP0001970_abnormal_pain_threshold0.90834546
115MP0001919_abnormal_reproductive_system0.90271295
116MP0000716_abnormal_immune_system0.89539752
117MP0003861_abnormal_nervous_system0.89081535
118MP0002152_abnormal_brain_morphology0.88647739
119MP0004147_increased_porphyrin_level0.88523724
120MP0005386_behavior/neurological_phenoty0.88260927
121MP0004924_abnormal_behavior0.88260927
122MP0003718_maternal_effect0.87680243
123MP0002735_abnormal_chemical_nociception0.87183745
124MP0003252_abnormal_bile_duct0.86553457
125MP0008057_abnormal_DNA_replication0.85824564
126MP0002095_abnormal_skin_pigmentation0.85621801
127MP0001661_extended_life_span0.85561841
128MP0005025_abnormal_response_to0.85059127
129MP0005389_reproductive_system_phenotype0.84690152
130MP0000026_abnormal_inner_ear0.82802760
131MP0002229_neurodegeneration0.82781117
132MP0001293_anophthalmia0.81726343
133MP0002398_abnormal_bone_marrow0.81547346
134MP0005410_abnormal_fertilization0.81081497
135MP0003136_yellow_coat_color0.80371754
136MP0003806_abnormal_nucleotide_metabolis0.80157068
137MP0008932_abnormal_embryonic_tissue0.79702369
138MP0002653_abnormal_ependyma_morphology0.78147402
139MP0002405_respiratory_system_inflammati0.77342729
140MP0002234_abnormal_pharynx_morphology0.77202105
141MP0004742_abnormal_vestibular_system0.76976779
142MP0000230_abnormal_systemic_arterial0.76710986
143MP0003866_abnormal_defecation0.76510089
144MP0008872_abnormal_physiological_respon0.75037209
145MP0000049_abnormal_middle_ear0.74169063
146MP0008875_abnormal_xenobiotic_pharmacok0.73117304
147MP0002127_abnormal_cardiovascular_syste0.71922576
148MP0001845_abnormal_inflammatory_respons0.71714167
149MP0001486_abnormal_startle_reflex0.71673867
150MP0009379_abnormal_foot_pigmentation0.71232869
151MP0002163_abnormal_gland_morphology0.70829145
152MP0005253_abnormal_eye_physiology0.70430492
153MP0003137_abnormal_impulse_conducting0.68732745
154MP0005379_endocrine/exocrine_gland_phen0.68564245
155MP0000747_muscle_weakness0.68555932
156MP0003880_abnormal_central_pattern0.67823480
157MP0001542_abnormal_bone_strength0.65651785
158MP0008058_abnormal_DNA_repair0.63362482
159MP0004811_abnormal_neuron_physiology0.62790630
160MP0009672_abnormal_birth_weight0.62446236
161MP0002066_abnormal_motor_capabilities/c0.62282666
162MP0000003_abnormal_adipose_tissue0.62139093
163MP0009053_abnormal_anal_canal0.62088497
164MP0002210_abnormal_sex_determination0.61878172
165MP0001727_abnormal_embryo_implantation0.61342089
166MP0001286_abnormal_eye_development0.61310433

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.98876097
2Failure to thrive in infancy (HP:0001531)4.78167784
3Acute necrotizing encephalopathy (HP:0006965)4.73633864
4Abnormal hair whorl (HP:0010721)4.31282110
5Congenital stationary night blindness (HP:0007642)4.29985373
6Hypoglycemic seizures (HP:0002173)4.14872226
7Polyphagia (HP:0002591)4.08859165
8Congenital malformation of the right heart (HP:0011723)4.04545730
9Double outlet right ventricle (HP:0001719)4.04545730
10Acute encephalopathy (HP:0006846)4.01348853
11Abnormal mitochondria in muscle tissue (HP:0008316)3.97485189
12Progressive macrocephaly (HP:0004481)3.90312146
13Abnormal ciliary motility (HP:0012262)3.68231623
14Hypothermia (HP:0002045)3.63864872
15Atonic seizures (HP:0010819)3.50950194
16Gait imbalance (HP:0002141)3.43884104
17Febrile seizures (HP:0002373)3.35495224
18Decreased electroretinogram (ERG) amplitude (HP:0000654)3.34251728
19Abnormal respiratory epithelium morphology (HP:0012253)3.29493171
20Abnormal respiratory motile cilium morphology (HP:0005938)3.29493171
21Myokymia (HP:0002411)3.29015584
22Mitochondrial inheritance (HP:0001427)3.28622187
23Congenital primary aphakia (HP:0007707)3.27423812
24Supernumerary spleens (HP:0009799)3.26834654
25Decreased central vision (HP:0007663)3.25266093
26Attenuation of retinal blood vessels (HP:0007843)3.24793908
27Pelvic girdle muscle weakness (HP:0003749)3.18038967
28Genetic anticipation (HP:0003743)3.17460387
29Abnormality of the renal cortex (HP:0011035)3.15711590
30True hermaphroditism (HP:0010459)3.14369921
31Medial flaring of the eyebrow (HP:0010747)3.11477636
32Retinal dysplasia (HP:0007973)3.08616180
33Abnormal respiratory motile cilium physiology (HP:0012261)3.05237466
34Abolished electroretinogram (ERG) (HP:0000550)3.04657458
35Symptomatic seizures (HP:0011145)2.94654368
36Abnormal rod and cone electroretinograms (HP:0008323)2.92985846
37Abnormality of the musculature of the pelvis (HP:0001469)2.92528123
38Abnormality of the hip-girdle musculature (HP:0001445)2.92528123
39Genital tract atresia (HP:0001827)2.91707943
40Severe visual impairment (HP:0001141)2.91457323
41Facial cleft (HP:0002006)2.85954356
42Narrow nasal bridge (HP:0000446)2.84860337
43Progressive cerebellar ataxia (HP:0002073)2.83743137
44Bifid tongue (HP:0010297)2.81174567
45Palpitations (HP:0001962)2.79742788
46Vaginal atresia (HP:0000148)2.79411439
47Nephrogenic diabetes insipidus (HP:0009806)2.77505354
48Increased CSF lactate (HP:0002490)2.73361155
49Gaze-evoked nystagmus (HP:0000640)2.73295116
50Abnormality of the renal medulla (HP:0100957)2.72964157
51Molar tooth sign on MRI (HP:0002419)2.67732937
52Abnormality of midbrain morphology (HP:0002418)2.67732937
53Stomach cancer (HP:0012126)2.67352869
54Cerebral edema (HP:0002181)2.67191056
55Oligomenorrhea (HP:0000876)2.62439950
56Absence seizures (HP:0002121)2.62043454
57Abnormality of macular pigmentation (HP:0008002)2.61636131
58Exercise intolerance (HP:0003546)2.60274415
59Abnormal drinking behavior (HP:0030082)2.58566961
60Polydipsia (HP:0001959)2.58566961
61Stomatitis (HP:0010280)2.58554374
62Thyroiditis (HP:0100646)2.58080431
63Pancreatic fibrosis (HP:0100732)2.57765938
64Rhinitis (HP:0012384)2.56560014
65IgG deficiency (HP:0004315)2.55490767
66Progressive external ophthalmoplegia (HP:0000590)2.52516608
67Pendular nystagmus (HP:0012043)2.51781946
68Impulsivity (HP:0100710)2.49662955
69Abnormality of pain sensation (HP:0010832)2.49356921
70Impaired pain sensation (HP:0007328)2.49356921
71Generalized hypotonia (HP:0001290)2.49230601
72Delayed CNS myelination (HP:0002188)2.47824943
73Hyperventilation (HP:0002883)2.46449525
74Elevated erythrocyte sedimentation rate (HP:0003565)2.42488301
75Poor suck (HP:0002033)2.41801358
76Poor coordination (HP:0002370)2.41574731
77Large for gestational age (HP:0001520)2.36369949
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.36340753
79Median cleft lip (HP:0000161)2.36009571
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35768978
81Progressive inability to walk (HP:0002505)2.34198041
82Renal cortical cysts (HP:0000803)2.30562253
83Tubular atrophy (HP:0000092)2.30136259
84Abnormal delayed hypersensitivity skin test (HP:0002963)2.28665895
85Sleep apnea (HP:0010535)2.28419545
86Nephronophthisis (HP:0000090)2.25699074
87Severe combined immunodeficiency (HP:0004430)2.25506949
88Bilateral microphthalmos (HP:0007633)2.24240669
89Leukodystrophy (HP:0002415)2.23700753
90Abnormality of T cell number (HP:0011839)2.23402040
91Inability to walk (HP:0002540)2.20816500
92Decreased circulating renin level (HP:0003351)2.20770076
93Truncus arteriosus (HP:0001660)2.19713730
94Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19512725
95Cystic liver disease (HP:0006706)2.18422275
96Chronic hepatic failure (HP:0100626)2.17746104
97Rimmed vacuoles (HP:0003805)2.17647252
98Patellar aplasia (HP:0006443)2.15925992
99Abnormality of dentin (HP:0010299)2.14836853
100Degeneration of anterior horn cells (HP:0002398)2.13693931
101Abnormality of the anterior horn cell (HP:0006802)2.13693931
102Labial hypoplasia (HP:0000066)2.13628315
103Aplasia/Hypoplasia of the patella (HP:0006498)2.13074620
104Prostate neoplasm (HP:0100787)2.12876284
105Aplasia/Hypoplasia of the spleen (HP:0010451)2.11534915
106Abnormality of T cells (HP:0002843)2.11048342
107Abnormality of T cell physiology (HP:0011840)2.10476545
108Focal seizures (HP:0007359)2.10145777
109Type II lissencephaly (HP:0007260)2.08476114
110Dialeptic seizures (HP:0011146)2.08370129
111Scrotal hypoplasia (HP:0000046)2.08275915
112Esotropia (HP:0000565)2.08230944
113Keratoconus (HP:0000563)2.07126562
114Increased corneal curvature (HP:0100692)2.07126562
115Optic neuritis (HP:0100653)2.06977236
116Retrobulbar optic neuritis (HP:0100654)2.06977236
117Polyuria (HP:0000103)2.06735148
118Increased hepatocellular lipid droplets (HP:0006565)2.06251421
119Transposition of the great arteries (HP:0001669)2.05403120
120Abnormal connection of the cardiac segments (HP:0011545)2.05403120
121Abnormal ventriculo-arterial connection (HP:0011563)2.05403120
122Asplenia (HP:0001746)2.04569781
123Bile duct proliferation (HP:0001408)2.03392292
124Abnormal biliary tract physiology (HP:0012439)2.03392292
125Anosmia (HP:0000458)2.03026410
126Respiratory failure (HP:0002878)2.02814919
127T lymphocytopenia (HP:0005403)2.01912879
128Abnormal eating behavior (HP:0100738)2.01855580
129Specific learning disability (HP:0001328)1.98645031
130Decreased testicular size (HP:0008734)1.98532208
131Optic disc pallor (HP:0000543)1.97816986
132Clumsiness (HP:0002312)1.97283668
133Abnormal lung lobation (HP:0002101)1.96437869
134Abnormality of aromatic amino acid family metabolism (HP:0004338)1.94737754
135Bony spicule pigmentary retinopathy (HP:0007737)1.94138262
136Sclerocornea (HP:0000647)1.94015464
137Hypoplasia of the pons (HP:0012110)1.91836128
138Hypoplastic female external genitalia (HP:0012815)1.91418685
139Hypoplasia of the fovea (HP:0007750)1.91405884
140Aplasia/Hypoplasia of the fovea (HP:0008060)1.91405884
141Pancreatic cysts (HP:0001737)1.91369194
142Hepatocellular necrosis (HP:0001404)1.90864226
143Constricted visual fields (HP:0001133)1.90262900
144Broad-based gait (HP:0002136)1.90222635
145Ketosis (HP:0001946)1.90217166
146Focal motor seizures (HP:0011153)1.89741515
147Renal Fanconi syndrome (HP:0001994)1.89122586
148Abnormality of eosinophils (HP:0001879)1.88898882
149Postaxial hand polydactyly (HP:0001162)1.88555375
150Progressive microcephaly (HP:0000253)1.88367234
151Generalized tonic-clonic seizures (HP:0002069)1.88256960
152Methylmalonic aciduria (HP:0012120)1.87843796
1533-Methylglutaconic aciduria (HP:0003535)1.87805992
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87628921
155Abnormal protein N-linked glycosylation (HP:0012347)1.87628921
156Abnormal protein glycosylation (HP:0012346)1.87628921
157Abnormal glycosylation (HP:0012345)1.87628921
158Ketoacidosis (HP:0001993)1.87322997
159Methylmalonic acidemia (HP:0002912)1.86749176
160Abnormal number of incisors (HP:0011064)1.85635003
161Abnormality of the pons (HP:0007361)1.85446769
162Congenital hepatic fibrosis (HP:0002612)1.84659779
163Congenital sensorineural hearing impairment (HP:0008527)1.83323971
164Panhypogammaglobulinemia (HP:0003139)1.83150414
165Aplasia/Hypoplasia of the lens (HP:0008063)1.82712565
166Abnormality of the prostate (HP:0008775)1.81803091
167Macular degeneration (HP:0000608)1.81552644
168Ectopic anus (HP:0004397)1.81089468
169Anophthalmia (HP:0000528)1.80861290
170Abnormality of B cell number (HP:0010975)1.80574765
171Cerebellar dysplasia (HP:0007033)1.79111355
172Chorioretinal atrophy (HP:0000533)1.75755058
173Furrowed tongue (HP:0000221)1.75730776
174Hypoventilation (HP:0002791)1.75680444
175Difficulty climbing stairs (HP:0003551)1.75474231
176Hemiparesis (HP:0001269)1.75058030
177Chronic diarrhea (HP:0002028)1.74973063
178Hyperglycinemia (HP:0002154)1.73970900
179Alveolar cell carcinoma (HP:0006519)1.73621016
180Autoimmune thrombocytopenia (HP:0001973)1.72869215
181Lissencephaly (HP:0001339)1.71205582
182Aplasia/Hypoplasia of the tibia (HP:0005772)1.70561013
183Keratoconjunctivitis (HP:0001096)1.69959160
184Fair hair (HP:0002286)1.69469215
185Neoplasm of the tracheobronchial system (HP:0100552)1.67402377
186Recurrent cutaneous fungal infections (HP:0011370)1.65992921
187Chronic mucocutaneous candidiasis (HP:0002728)1.65992921

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.56692699
2ERBB35.13841928
3BMPR24.59554322
4BUB13.59545383
5ARAF3.35288190
6PNCK3.32021285
7TXK3.26414814
8TAOK33.06826274
9NTRK23.04490663
10SRPK12.57254877
11BMPR1B2.45207334
12INSRR2.44216561
13NTRK32.35254652
14MARK12.32169925
15MAP4K22.27028413
16PLK42.25992884
17MAPK152.21191044
18AKT31.97487355
19PINK11.93111766
20PRPF4B1.89018247
21NUAK11.86991729
22WNK31.85165905
23NME11.75525178
24PHKG21.74438046
25PHKG11.74438046
26MAP4K11.62563264
27MAP3K91.60967563
28TNK21.57695353
29STK391.57683233
30MAP3K121.57184746
31SIK31.53652614
32IRAK41.53164171
33OXSR11.52590747
34BCKDK1.48774026
35SIK21.47146373
36MST41.46641966
37MAP3K131.44962593
38MAP3K101.41449482
39ADRBK21.40696535
40STK241.39830874
41KIT1.30887633
42MAP2K41.30174784
43FES1.27621779
44IKBKE1.27000695
45ITK1.25386534
46MAP3K41.24696989
47PLK31.23165659
48BRAF1.22506896
49TEC1.21534808
50PAK31.21389627
51EPHA21.21020948
52IKBKB1.18601643
53TLK11.17268836
54NLK1.16690331
55NME21.16594067
56UHMK11.15193762
57STK38L1.14799342
58SYK1.13664934
59MINK11.13243017
60IRAK21.13016057
61VRK11.12511000
62TSSK61.08356183
63OBSCN1.01488426
64MAPK130.99182780
65PLK10.99019077
66ZAP700.98372185
67GRK60.98096672
68DAPK20.97652148
69PRKCQ0.95961935
70AURKA0.92158125
71PTK2B0.91550150
72ZAK0.90864429
73DYRK20.85991586
74MAP2K70.85300673
75IRAK30.84794187
76PRKCE0.84448743
77FGFR20.82277585
78KSR20.80566553
79LCK0.80396556
80CAMK2G0.79421987
81WEE10.79251028
82BTK0.78926608
83PRKCI0.78828063
84MUSK0.78776970
85PLK20.77301635
86KSR10.76539590
87NTRK10.76485269
88BLK0.76275525
89GRK70.75299340
90WNK40.73050561
91LYN0.72717966
92FER0.71524684
93TRIM280.71323913
94LATS20.69791352
95JAK30.68788921
96DYRK30.68495660
97TYRO30.67826567
98MAP2K60.67635105
99MAPKAPK30.67498179
100MARK30.65235700
101PASK0.64988096
102BCR0.64741657
103HCK0.64657164
104TAF10.63887665
105PIK3CG0.63600657
106CAMK2B0.62680547
107STK110.61295444
108RIPK40.61017729
109STK160.59864613
110CHUK0.57765841
111LMTK20.56679985
112CSNK1G30.56524755
113GRK50.54817125
114TYK20.54670841
115DYRK1A0.54664559
116MAP3K70.54116122
117ADRBK10.53487590
118TNIK0.53139926
119CSF1R0.52978818
120MAP2K20.52732156
121ACVR1B0.52702576
122CAMK2D0.48547658
123CAMK1G0.47481150
124EIF2AK30.46677581
125CSNK1G10.46618659
126PIM20.46569158
127CAMKK10.45410913
128RPS6KB20.45293714
129PRKAA20.44835134
130ABL10.44521764
131CSNK1E0.44415894
132NEK90.43703974
133RPS6KA50.43682101
134CAMK40.43563392
135CDK140.43428537
136TIE10.43379220
137CAMK2A0.43370579
138CSNK1G20.43323667
139TGFBR10.43031723
140LIMK10.40608959
141MAP3K140.40109928
142SGK20.40091142
143CAMKK20.39769346
144CDK50.39664766
145MYLK0.38380390
146CAMK10.38052356
147MKNK20.37914421
148PIK3CA0.37246765
149PIM10.37032438
150MAP3K20.36332825
151TESK10.35465939
152YES10.34112989
153BRD40.33798582
154CDK180.33756468
155JAK10.33174571
156CSNK1A10.32688691
157DAPK30.32311159
158CSNK2A10.32208081
159CSNK1A1L0.31964758
160PRKACA0.31267680
161CDK150.31245925
162CDK11A0.30991313
163MAPK90.29886764
164CASK0.29537621
165GRK10.29314693
166IRAK10.29309248
167PRKCG0.28221714

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.63649357
2Parkinsons disease_Homo sapiens_hsa050124.13114661
3Proteasome_Homo sapiens_hsa030503.86477320
4Ribosome_Homo sapiens_hsa030103.83237390
5Huntingtons disease_Homo sapiens_hsa050163.22141423
6RNA polymerase_Homo sapiens_hsa030203.06527277
7Alzheimers disease_Homo sapiens_hsa050102.87132350
8Primary immunodeficiency_Homo sapiens_hsa053402.84545893
9Olfactory transduction_Homo sapiens_hsa047402.66888932
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.66542094
11Linoleic acid metabolism_Homo sapiens_hsa005912.28275892
12Collecting duct acid secretion_Homo sapiens_hsa049662.24571940
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.19658532
14Graft-versus-host disease_Homo sapiens_hsa053322.14032397
15Nicotine addiction_Homo sapiens_hsa050332.13577148
16Synaptic vesicle cycle_Homo sapiens_hsa047212.05189950
17Allograft rejection_Homo sapiens_hsa053302.02792366
18Type I diabetes mellitus_Homo sapiens_hsa049402.01150718
19Cardiac muscle contraction_Homo sapiens_hsa042602.00921680
20Autoimmune thyroid disease_Homo sapiens_hsa053201.98922095
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94364455
22Asthma_Homo sapiens_hsa053101.91556804
23Ether lipid metabolism_Homo sapiens_hsa005651.90173721
24Maturity onset diabetes of the young_Homo sapiens_hsa049501.89033802
25Folate biosynthesis_Homo sapiens_hsa007901.85953058
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.82666098
27Pyrimidine metabolism_Homo sapiens_hsa002401.80488796
28Butanoate metabolism_Homo sapiens_hsa006501.78686393
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78395102
30Nitrogen metabolism_Homo sapiens_hsa009101.77024879
31Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.75998957
32Spliceosome_Homo sapiens_hsa030401.72373121
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61126292
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.58470985
35Homologous recombination_Homo sapiens_hsa034401.56172815
36Sulfur relay system_Homo sapiens_hsa041221.49461903
37Taste transduction_Homo sapiens_hsa047421.48727516
38GABAergic synapse_Homo sapiens_hsa047271.45792187
39Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37069790
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.36411722
41Phototransduction_Homo sapiens_hsa047441.34524217
42Vibrio cholerae infection_Homo sapiens_hsa051101.34491351
43Tryptophan metabolism_Homo sapiens_hsa003801.33831924
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32881506
45Fanconi anemia pathway_Homo sapiens_hsa034601.30964885
46Protein export_Homo sapiens_hsa030601.28784528
47Serotonergic synapse_Homo sapiens_hsa047261.25201722
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24191772
49Selenocompound metabolism_Homo sapiens_hsa004501.21991582
50ABC transporters_Homo sapiens_hsa020101.19916226
51Caffeine metabolism_Homo sapiens_hsa002321.19070595
52Purine metabolism_Homo sapiens_hsa002301.18119604
53RNA transport_Homo sapiens_hsa030131.17429434
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.16651405
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13626606
56mRNA surveillance pathway_Homo sapiens_hsa030151.13088152
57Dopaminergic synapse_Homo sapiens_hsa047281.05379152
58Amphetamine addiction_Homo sapiens_hsa050311.03936723
59Basal transcription factors_Homo sapiens_hsa030221.03585249
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01419453
61Melanogenesis_Homo sapiens_hsa049161.01414121
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99253821
63Galactose metabolism_Homo sapiens_hsa000520.98404099
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.97569890
65Retinol metabolism_Homo sapiens_hsa008300.97065294
66Hematopoietic cell lineage_Homo sapiens_hsa046400.94948870
67Antigen processing and presentation_Homo sapiens_hsa046120.94917125
68Oocyte meiosis_Homo sapiens_hsa041140.94032048
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92982304
70Circadian entrainment_Homo sapiens_hsa047130.90956979
71Prion diseases_Homo sapiens_hsa050200.90217198
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.89884782
73Morphine addiction_Homo sapiens_hsa050320.89170845
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88800152
75Nucleotide excision repair_Homo sapiens_hsa034200.88498780
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.88233829
77Glutamatergic synapse_Homo sapiens_hsa047240.88041385
78Chemical carcinogenesis_Homo sapiens_hsa052040.87291746
79Base excision repair_Homo sapiens_hsa034100.86691458
80Peroxisome_Homo sapiens_hsa041460.85743527
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85694351
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85522879
83T cell receptor signaling pathway_Homo sapiens_hsa046600.84949035
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.84930704
85Rheumatoid arthritis_Homo sapiens_hsa053230.84601434
86Long-term potentiation_Homo sapiens_hsa047200.81926794
87Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81858776
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80471554
89Mismatch repair_Homo sapiens_hsa034300.79490486
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79104149
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78306875
92Cholinergic synapse_Homo sapiens_hsa047250.77991279
93Cocaine addiction_Homo sapiens_hsa050300.77803712
94DNA replication_Homo sapiens_hsa030300.76310206
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.76070444
96Alcoholism_Homo sapiens_hsa050340.75141773
97Glycerolipid metabolism_Homo sapiens_hsa005610.74336668
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73523685
99Dorso-ventral axis formation_Homo sapiens_hsa043200.73295364
100RNA degradation_Homo sapiens_hsa030180.72535006
101Staphylococcus aureus infection_Homo sapiens_hsa051500.70901733
102Calcium signaling pathway_Homo sapiens_hsa040200.68436024
103Ovarian steroidogenesis_Homo sapiens_hsa049130.67734862
104Long-term depression_Homo sapiens_hsa047300.66604755
105Salivary secretion_Homo sapiens_hsa049700.66136585
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63520302
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.63210010
108Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.63192651
109Circadian rhythm_Homo sapiens_hsa047100.63177891
110Thyroid cancer_Homo sapiens_hsa052160.62002305
111Metabolic pathways_Homo sapiens_hsa011000.59602490
112Hedgehog signaling pathway_Homo sapiens_hsa043400.59116512
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57902717
114Basal cell carcinoma_Homo sapiens_hsa052170.56787882
115Measles_Homo sapiens_hsa051620.56168378
116Drug metabolism - other enzymes_Homo sapiens_hsa009830.55604812
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55303553
118Tight junction_Homo sapiens_hsa045300.54003972
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53987485
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51479915
121Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50698984
122Herpes simplex infection_Homo sapiens_hsa051680.50068315
123Cell cycle_Homo sapiens_hsa041100.49393564
124GnRH signaling pathway_Homo sapiens_hsa049120.48712899
125Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43487548
126Pyruvate metabolism_Homo sapiens_hsa006200.41786685
127Leishmaniasis_Homo sapiens_hsa051400.41642339
128beta-Alanine metabolism_Homo sapiens_hsa004100.38401385
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.38315790
130Arginine and proline metabolism_Homo sapiens_hsa003300.38071506
131Vitamin B6 metabolism_Homo sapiens_hsa007500.37210934
132Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36701894
133Epstein-Barr virus infection_Homo sapiens_hsa051690.36385730
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36239910
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.35715498
136Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.34930724
137Wnt signaling pathway_Homo sapiens_hsa043100.34870773
138Fatty acid elongation_Homo sapiens_hsa000620.34170648
139Arachidonic acid metabolism_Homo sapiens_hsa005900.33194109
140Glutathione metabolism_Homo sapiens_hsa004800.33044756
141Tuberculosis_Homo sapiens_hsa051520.32334528
142Renin secretion_Homo sapiens_hsa049240.31259904
143Oxytocin signaling pathway_Homo sapiens_hsa049210.31087395
144Axon guidance_Homo sapiens_hsa043600.30876072
145Tyrosine metabolism_Homo sapiens_hsa003500.30273186
146Vitamin digestion and absorption_Homo sapiens_hsa049770.30076222
147Type II diabetes mellitus_Homo sapiens_hsa049300.29652199
148Insulin secretion_Homo sapiens_hsa049110.29038436
149Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28862563
150Glucagon signaling pathway_Homo sapiens_hsa049220.28764315
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28488631
152Hippo signaling pathway_Homo sapiens_hsa043900.28310586
153Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.28002140
154p53 signaling pathway_Homo sapiens_hsa041150.27142605
155Propanoate metabolism_Homo sapiens_hsa006400.25427870
156Colorectal cancer_Homo sapiens_hsa052100.24893517
157Adipocytokine signaling pathway_Homo sapiens_hsa049200.24345639
158alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24198386
159Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.23865132
160Estrogen signaling pathway_Homo sapiens_hsa049150.23399552
161Regulation of autophagy_Homo sapiens_hsa041400.23281236
162Gap junction_Homo sapiens_hsa045400.20838177
163Sphingolipid metabolism_Homo sapiens_hsa006000.20793113
164Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20620350
165Bladder cancer_Homo sapiens_hsa052190.20058765
166One carbon pool by folate_Homo sapiens_hsa006700.19890188

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