FAM159B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.90763771
2COPI coating of Golgi vesicle (GO:0048205)6.90763771
3endocrine pancreas development (GO:0031018)5.99529179
4signal peptide processing (GO:0006465)5.90648820
5detection of calcium ion (GO:0005513)5.84468862
6positive regulation of glycolytic process (GO:0045821)5.05472079
7lactate metabolic process (GO:0006089)4.97934376
8glandular epithelial cell differentiation (GO:0002067)4.91837926
9ER overload response (GO:0006983)4.71899394
10positive regulation of respiratory burst (GO:0060267)4.61811636
11glandular epithelial cell development (GO:0002068)4.61340442
12protein maturation by protein folding (GO:0022417)4.52044581
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.51274247
14respiratory chain complex IV assembly (GO:0008535)4.50390461
15type B pancreatic cell development (GO:0003323)4.46998953
16peptide hormone processing (GO:0016486)4.35023251
17water-soluble vitamin biosynthetic process (GO:0042364)4.31604304
18insulin secretion (GO:0030073)4.30565332
19positive regulation of protein autophosphorylation (GO:0031954)4.29909770
20regulation of beta-amyloid formation (GO:1902003)4.27350569
21UDP-N-acetylglucosamine metabolic process (GO:0006047)4.21915109
22negative regulation of gluconeogenesis (GO:0045721)4.10310162
23L-alpha-amino acid transmembrane transport (GO:1902475)4.08493719
24fatty acid homeostasis (GO:0055089)4.07883032
25negative regulation of protein oligomerization (GO:0032460)4.03889094
26regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.01837144
27retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.99520814
28positive regulation of insulin secretion (GO:0032024)3.97634287
29positive regulation of protein sumoylation (GO:0033235)3.96661523
30regulation of insulin secretion (GO:0050796)3.92521378
31negative regulation of hormone biosynthetic process (GO:0032353)3.92335020
32cytochrome complex assembly (GO:0017004)3.91410659
33protein retention in ER lumen (GO:0006621)3.89270870
34regulation of glucocorticoid secretion (GO:2000849)3.86930658
35negative regulation of acute inflammatory response (GO:0002674)3.84430243
36macroautophagy (GO:0016236)3.84242554
37inositol phosphate catabolic process (GO:0071545)3.77375291
38kidney morphogenesis (GO:0060993)3.75507194
39negative regulation of glycogen metabolic process (GO:0070874)3.71926984
40columnar/cuboidal epithelial cell development (GO:0002066)3.69869789
41nucleotide-sugar biosynthetic process (GO:0009226)3.69629813
42toxin metabolic process (GO:0009404)3.64002177
43regulation of peptide hormone secretion (GO:0090276)3.60813576
44protein K6-linked ubiquitination (GO:0085020)3.60325069
45inositol phosphate dephosphorylation (GO:0046855)3.55436008
46phosphorylated carbohydrate dephosphorylation (GO:0046838)3.55436008
47phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.54039284
48regulation of peptide secretion (GO:0002791)3.53398708
49response to redox state (GO:0051775)3.52020201
50regulation of Golgi to plasma membrane protein transport (GO:0042996)3.51871668
51protein-cofactor linkage (GO:0018065)3.50632914
52regulation of mesoderm development (GO:2000380)3.47231084
53nodal signaling pathway (GO:0038092)3.47127667
54positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.45585347
55signal transduction involved in regulation of gene expression (GO:0023019)3.44677387
56regulation of type B pancreatic cell apoptotic process (GO:2000674)3.41916453
57regulation of corticosteroid hormone secretion (GO:2000846)3.37664395
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.36991596
59COPII vesicle coating (GO:0048208)3.34386485
60positive regulation of glycogen biosynthetic process (GO:0045725)3.31675918
61positive regulation of peptide hormone secretion (GO:0090277)3.29965819
62regulation of amyloid precursor protein catabolic process (GO:1902991)3.29569106
63negative regulation of hormone metabolic process (GO:0032351)3.25441411
64magnesium ion transport (GO:0015693)3.25231747
65neuromuscular process controlling posture (GO:0050884)3.20256556
66negative regulation of transcription by competitive promoter binding (GO:0010944)3.19610538
67cranial nerve development (GO:0021545)3.18930218
68regulation of hormone secretion (GO:0046883)3.18564080
69regulation of hexokinase activity (GO:1903299)3.18154888
70regulation of glucokinase activity (GO:0033131)3.18154888
71positive regulation of peptide secretion (GO:0002793)3.17834313
72protein localization to Golgi apparatus (GO:0034067)3.17513141
73eating behavior (GO:0042755)3.16567260
74astrocyte differentiation (GO:0048708)3.14231774
75peptide hormone secretion (GO:0030072)3.12736573
76protein complex biogenesis (GO:0070271)3.12683039
77interleukin-1-mediated signaling pathway (GO:0070498)3.12083034
78presynaptic membrane assembly (GO:0097105)3.11638585
79GDP-mannose metabolic process (GO:0019673)3.11335818
80oxygen transport (GO:0015671)3.11038452
81positive regulation of response to nutrient levels (GO:0032109)3.10100727
82positive regulation of response to extracellular stimulus (GO:0032106)3.10100727
83somite rostral/caudal axis specification (GO:0032525)3.08519680
84regulation of protein sumoylation (GO:0033233)3.07889940
85cellular ketone body metabolic process (GO:0046950)3.07808902
86positive regulation of amino acid transport (GO:0051957)3.06960668
87positive regulation of macroautophagy (GO:0016239)3.06763310
88intestinal epithelial cell development (GO:0060576)3.06342486
89epithelial cell fate commitment (GO:0072148)3.06153642
90negative regulation of activin receptor signaling pathway (GO:0032926)3.05455568
91chemosensory behavior (GO:0007635)3.04598003
92nucleoside diphosphate catabolic process (GO:0009134)3.04397264
93activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.03521213
94peptide secretion (GO:0002790)3.01970659
95innervation (GO:0060384)3.01171878
96regulation of calcium ion-dependent exocytosis (GO:0017158)3.00886434
97intraciliary transport (GO:0042073)3.00824671
98glycoside metabolic process (GO:0016137)3.00610485
99positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.98289544
100embryonic retina morphogenesis in camera-type eye (GO:0060059)2.96110521
101mitochondrial respiratory chain complex assembly (GO:0033108)2.90202350
102glucosamine-containing compound catabolic process (GO:1901072)2.89654190
103response to hepatocyte growth factor (GO:0035728)2.89263583
104cellular response to hepatocyte growth factor stimulus (GO:0035729)2.89263583
105regulation of oxidative phosphorylation (GO:0002082)2.89244221
106regulation of mitochondrial translation (GO:0070129)2.88868046
107vesicle coating (GO:0006901)2.88775568
108ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.86180898
109dorsal/ventral axis specification (GO:0009950)2.86178183
110mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.84949698
111positive regulation of nuclease activity (GO:0032075)2.84692330
112negative regulation of bone resorption (GO:0045779)2.84666998
113cornea development in camera-type eye (GO:0061303)2.84581611
114positive regulation of glycogen metabolic process (GO:0070875)2.83918910
115regulation of peptide transport (GO:0090087)2.83443260
116negative regulation of neurological system process (GO:0031645)2.82816478
117dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.82806452
118proteasome assembly (GO:0043248)2.81054802
119pancreas development (GO:0031016)2.80036077
120sequestering of metal ion (GO:0051238)2.78126775
121single strand break repair (GO:0000012)2.78018493
122Golgi to plasma membrane protein transport (GO:0043001)2.77433499
123primitive streak formation (GO:0090009)2.76090952
124peptidyl-histidine modification (GO:0018202)2.74766994
125polyol catabolic process (GO:0046174)2.72411956
126ER to Golgi vesicle-mediated transport (GO:0006888)2.72246063
127intra-Golgi vesicle-mediated transport (GO:0006891)2.71852038
128regulation of cellular amide metabolic process (GO:0034248)2.71361506
129nitric oxide mediated signal transduction (GO:0007263)2.69961351
130ketone body metabolic process (GO:1902224)2.69797366
131neuron cell-cell adhesion (GO:0007158)2.69402842
132regulation of nuclease activity (GO:0032069)2.67310951
133phosphatidylinositol dephosphorylation (GO:0046856)2.67207105
134positive regulation of vesicle fusion (GO:0031340)2.66992715
135positive regulation of insulin receptor signaling pathway (GO:0046628)2.66348147
136zinc ion transport (GO:0006829)2.64809209
137protein targeting to Golgi (GO:0000042)2.62991749
138hindbrain development (GO:0030902)2.62122420
139cellular response to topologically incorrect protein (GO:0035967)2.61888111
140cellular response to unfolded protein (GO:0034620)2.61855996
141polyketide metabolic process (GO:0030638)2.61388397
142doxorubicin metabolic process (GO:0044598)2.61388397
143daunorubicin metabolic process (GO:0044597)2.61388397
144positive regulation of DNA-templated transcription, initiation (GO:2000144)2.60507984
145glycerophospholipid catabolic process (GO:0046475)2.59897570
146positive regulation of hormone secretion (GO:0046887)2.59690599
147DNA deamination (GO:0045006)2.56034083
148neuron fate determination (GO:0048664)2.55679494
149DNA double-strand break processing (GO:0000729)2.54656011
150zinc ion transmembrane transport (GO:0071577)2.53152755
151female gonad development (GO:0008585)2.51799423
152protein neddylation (GO:0045116)2.51381918
153platelet dense granule organization (GO:0060155)2.49019942
154keratinocyte development (GO:0003334)2.46286006
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.43896645
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.43896645
157cullin deneddylation (GO:0010388)2.43824408
158exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.43242389
159dendritic spine morphogenesis (GO:0060997)2.42425652
160chaperone-mediated protein transport (GO:0072321)2.41312712
161histone H2A ubiquitination (GO:0033522)2.40514115
162regulation of protein autophosphorylation (GO:0031952)2.38116659
163chromatin remodeling at centromere (GO:0031055)2.36850748
164regulation of feeding behavior (GO:0060259)2.35864713
165branched-chain amino acid catabolic process (GO:0009083)2.35119583
166transcription elongation from RNA polymerase III promoter (GO:0006385)2.34446423
167termination of RNA polymerase III transcription (GO:0006386)2.34446423

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse6.97854096
2EZH2_22144423_ChIP-Seq_EOC_Human4.06417249
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.58406880
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49166734
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.89530384
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.87001323
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.85495306
8REST_21632747_ChIP-Seq_MESCs_Mouse2.53467688
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.27265997
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.26464644
11IGF1R_20145208_ChIP-Seq_DFB_Human2.18745172
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05675855
13GATA1_22025678_ChIP-Seq_K562_Human1.99291888
14SALL1_21062744_ChIP-ChIP_HESCs_Human1.99142779
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91365716
16GBX2_23144817_ChIP-Seq_PC3_Human1.90250757
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.89546242
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86857497
19PIAS1_25552417_ChIP-Seq_VCAP_Human1.85904063
20EWS_26573619_Chip-Seq_HEK293_Human1.80153251
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.76913821
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73163779
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70957387
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70499255
25TAF15_26573619_Chip-Seq_HEK293_Human1.68627309
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.68452855
27BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68008297
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66706774
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.65206906
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62220735
31BCAT_22108803_ChIP-Seq_LS180_Human1.61105036
32MYC_18940864_ChIP-ChIP_HL60_Human1.59714720
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58823388
34REST_19997604_ChIP-ChIP_NEURONS_Mouse1.55671127
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54479061
36REST_18959480_ChIP-ChIP_MESCs_Mouse1.54249238
37SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.49613415
38ELK1_19687146_ChIP-ChIP_HELA_Human1.48553869
39SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.43066754
40SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41465748
41AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40377083
42CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.39462722
43GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.38527906
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38418124
45EZH2_27294783_Chip-Seq_NPCs_Mouse1.38174640
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.37343772
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35077841
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34883072
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.33929350
50ELK1_22589737_ChIP-Seq_MCF10A_Human1.33689679
51ETS1_20019798_ChIP-Seq_JURKAT_Human1.33554062
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.32395450
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.30636568
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29170706
55RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.28086819
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27985800
57* SOX2_19829295_ChIP-Seq_ESCs_Human1.27371952
58* NANOG_19829295_ChIP-Seq_ESCs_Human1.27371952
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25478552
60CBP_20019798_ChIP-Seq_JUKART_Human1.25478552
61CDX2_22108803_ChIP-Seq_LS180_Human1.25285739
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24578504
63HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24536600
64VDR_22108803_ChIP-Seq_LS180_Human1.24366144
65TCF4_22108803_ChIP-Seq_LS180_Human1.24061929
66MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.22549487
67SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21939782
68ER_23166858_ChIP-Seq_MCF-7_Human1.21431715
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.20937311
70SMAD4_21741376_ChIP-Seq_EPCs_Human1.20245225
71SMAD_19615063_ChIP-ChIP_OVARY_Human1.19885344
72STAT3_23295773_ChIP-Seq_U87_Human1.17150862
73* FOXA1_25329375_ChIP-Seq_VCAP_Human1.16875019
74* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16875019
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16533221
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.14949365
77IRF1_19129219_ChIP-ChIP_H3396_Human1.14304349
78TP53_22573176_ChIP-Seq_HFKS_Human1.14174289
79FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13096882
80EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13029966
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.12567630
82CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12077476
83CRX_20693478_ChIP-Seq_RETINA_Mouse1.09190212
84AR_20517297_ChIP-Seq_VCAP_Human1.09126773
85P300_19829295_ChIP-Seq_ESCs_Human1.08711867
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08622125
87P53_22387025_ChIP-Seq_ESCs_Mouse1.08428772
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.08167907
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06749788
90KLF5_20875108_ChIP-Seq_MESCs_Mouse1.06668809
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06664175
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.06362913
93* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05721437
94VDR_23849224_ChIP-Seq_CD4+_Human1.05058711
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04123724
96SMAD3_21741376_ChIP-Seq_HESCs_Human1.03863493
97FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03426453
98P300_18555785_Chip-Seq_ESCs_Mouse1.03064224
99HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01720274
100GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.01557574
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.01347761
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.01034908
103CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99935877
104POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.99891548
105* FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98165918
106PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97821242
107NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.97659237
108FUS_26573619_Chip-Seq_HEK293_Human0.97626088
109CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97187596
110ZFP57_27257070_Chip-Seq_ESCs_Mouse0.97121035
111RARB_27405468_Chip-Seq_BRAIN_Mouse0.97100054
112SMAD4_21799915_ChIP-Seq_A2780_Human0.96689469
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.96679793
114OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96356808
115* FLI1_21867929_ChIP-Seq_TH2_Mouse0.96309266
116RUNX2_22187159_ChIP-Seq_PCA_Human0.96155955
117E2F1_18555785_Chip-Seq_ESCs_Mouse0.94984439
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94478725
119ETV2_25802403_ChIP-Seq_MESCs_Mouse0.94394407
120KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.94340189
121ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89465510
122TRIM28_21343339_ChIP-Seq_HEK293_Human0.89213174
123FLI1_27457419_Chip-Seq_LIVER_Mouse0.88663102
124ZNF274_21170338_ChIP-Seq_K562_Hela0.88024530
125SMAD3_21741376_ChIP-Seq_EPCs_Human0.87427671
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.85681912
127KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.85255673
128KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.85255673
129KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.85255673
130CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85147212
131SRF_21415370_ChIP-Seq_HL-1_Mouse0.84957738
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84547119
133TCF4_23295773_ChIP-Seq_U87_Human0.84369500
134CREB1_15753290_ChIP-ChIP_HEK293T_Human0.84069511
135EZH2_27304074_Chip-Seq_ESCs_Mouse0.84038190
136DCP1A_22483619_ChIP-Seq_HELA_Human0.83737122
137WT1_19549856_ChIP-ChIP_CCG9911_Human0.83570274
138PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82395810
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.81760888
140SOX2_21211035_ChIP-Seq_LN229_Gbm0.80863404
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.79231273
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.79024773
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.78458901
144FOXP3_21729870_ChIP-Seq_TREG_Human0.78346897
145NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77221170
146DROSHA_22980978_ChIP-Seq_HELA_Human0.75730849
147AR_25329375_ChIP-Seq_VCAP_Human0.74086447
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.73933913
149ERG_20887958_ChIP-Seq_HPC-7_Mouse0.73885123
150FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.73219532
151FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.73022228
152HTT_18923047_ChIP-ChIP_STHdh_Human0.72948631

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000013_abnormal_adipose_tissue5.74428878
2MP0003183_abnormal_peptide_metabolism4.24958285
3MP0009780_abnormal_chondrocyte_physiolo3.57567133
4MP0005645_abnormal_hypothalamus_physiol3.57299097
5MP0010386_abnormal_urinary_bladder3.56542248
6MP0002877_abnormal_melanocyte_morpholog3.30322189
7MP0008877_abnormal_DNA_methylation3.29928094
8MP0006292_abnormal_olfactory_placode3.20821606
9MP0004043_abnormal_pH_regulation3.20044471
10MP0003195_calcinosis3.01398609
11MP0003890_abnormal_embryonic-extraembry2.97436712
12MP0006072_abnormal_retinal_apoptosis2.93821520
13MP0002693_abnormal_pancreas_physiology2.92071973
14MP0003122_maternal_imprinting2.76943531
15MP0002837_dystrophic_cardiac_calcinosis2.68354491
16MP0010234_abnormal_vibrissa_follicle2.65968246
17MP0002909_abnormal_adrenal_gland2.64983573
18MP0005379_endocrine/exocrine_gland_phen2.62488581
19MP0002638_abnormal_pupillary_reflex2.59309334
20MP0001944_abnormal_pancreas_morphology2.55922578
21MP0002102_abnormal_ear_morphology2.12413330
22MP0005220_abnormal_exocrine_pancreas2.00445952
23MP0003283_abnormal_digestive_organ1.95987461
24MP0000003_abnormal_adipose_tissue1.92224866
25MP0004133_heterotaxia1.82047711
26MP0002078_abnormal_glucose_homeostasis1.78703384
27MP0003879_abnormal_hair_cell1.78507338
28MP0002938_white_spotting1.77375801
29MP0002138_abnormal_hepatobiliary_system1.76816350
30MP0001764_abnormal_homeostasis1.74367585
31MP0004264_abnormal_extraembryonic_tissu1.66111920
32MP0005670_abnormal_white_adipose1.66090639
33MP0002090_abnormal_vision1.65789948
34MP0003959_abnormal_lean_body1.57157184
35MP0001502_abnormal_circadian_rhythm1.55965520
36MP0002254_reproductive_system_inflammat1.55225268
37MP0003119_abnormal_digestive_system1.47900442
38MP0001664_abnormal_digestion1.44094120
39MP0002734_abnormal_mechanical_nocicepti1.43357524
40MP0000678_abnormal_parathyroid_gland1.43123488
41MP0001501_abnormal_sleep_pattern1.42502261
42MP0002272_abnormal_nervous_system1.38591248
43MP0005257_abnormal_intraocular_pressure1.37168121
44MP0005535_abnormal_body_temperature1.36271162
45MP0000372_irregular_coat_pigmentation1.36261223
46MP0005646_abnormal_pituitary_gland1.35157190
47MP0003136_yellow_coat_color1.33562724
48MP0002277_abnormal_respiratory_mucosa1.31205281
49MP0009046_muscle_twitch1.31185992
50MP0002876_abnormal_thyroid_physiology1.30012773
51MP0001529_abnormal_vocalization1.26752440
52MP0003011_delayed_dark_adaptation1.26620722
53MP0005058_abnormal_lysosome_morphology1.25130027
54MP0002163_abnormal_gland_morphology1.24344972
55MP0003567_abnormal_fetal_cardiomyocyte1.21922351
56MP0003123_paternal_imprinting1.21803923
57MP0005075_abnormal_melanosome_morpholog1.21606138
58MP0001440_abnormal_grooming_behavior1.21529839
59MP0006276_abnormal_autonomic_nervous1.20464699
60MP0003121_genomic_imprinting1.19170956
61MP0000613_abnormal_salivary_gland1.17756196
62MP0005551_abnormal_eye_electrophysiolog1.16016744
63MP0008058_abnormal_DNA_repair1.15317638
64MP0004270_analgesia1.14877185
65MP0005636_abnormal_mineral_homeostasis1.14286371
66MP0005084_abnormal_gallbladder_morpholo1.13203214
67MP0008961_abnormal_basal_metabolism1.12865630
68MP0000462_abnormal_digestive_system1.11601286
69MP0003953_abnormal_hormone_level1.10609147
70MP0002733_abnormal_thermal_nociception1.10124917
71MP0005367_renal/urinary_system_phenotyp1.08624582
72MP0000516_abnormal_urinary_system1.08624582
73MP0004145_abnormal_muscle_electrophysio1.08409900
74MP0003635_abnormal_synaptic_transmissio1.07972859
75MP0003868_abnormal_feces_composition1.07520730
76MP0004019_abnormal_vitamin_homeostasis1.05762632
77MP0000427_abnormal_hair_cycle1.03309897
78MP0001970_abnormal_pain_threshold1.01992061
79MP0008872_abnormal_physiological_respon1.01393631
80MP0000538_abnormal_urinary_bladder1.01171461
81MP0003786_premature_aging1.00833469
82MP0009697_abnormal_copulation0.98651071
83MP0005332_abnormal_amino_acid0.96723753
84MP0001986_abnormal_taste_sensitivity0.95307689
85MP0002735_abnormal_chemical_nociception0.95140364
86MP0005253_abnormal_eye_physiology0.94968286
87MP0002064_seizures0.94089140
88MP0005448_abnormal_energy_balance0.93805616
89MP0002184_abnormal_innervation0.91603433
90MP0001919_abnormal_reproductive_system0.91415945
91MP0002160_abnormal_reproductive_system0.91403987
92MP0004215_abnormal_myocardial_fiber0.90284029
93MP0005375_adipose_tissue_phenotype0.90277283
94MP0002896_abnormal_bone_mineralization0.90157777
95MP0001661_extended_life_span0.89336249
96MP0001905_abnormal_dopamine_level0.88811299
97MP0001765_abnormal_ion_homeostasis0.87472522
98MP0005389_reproductive_system_phenotype0.87424845
99MP0006054_spinal_hemorrhage0.86483609
100MP0000631_abnormal_neuroendocrine_gland0.85103282
101MP0002557_abnormal_social/conspecific_i0.84948139
102MP0008995_early_reproductive_senescence0.84906811
103MP0010678_abnormal_skin_adnexa0.83846923
104MP0002234_abnormal_pharynx_morphology0.83548668
105MP0004142_abnormal_muscle_tone0.83480298
106MP0003693_abnormal_embryo_hatching0.82787147
107MP0001968_abnormal_touch/_nociception0.82072002
108MP0005334_abnormal_fat_pad0.81954359
109MP0006035_abnormal_mitochondrial_morpho0.81833079
110MP0001188_hyperpigmentation0.81433653
111MP0002069_abnormal_eating/drinking_beha0.81323530
112MP0002229_neurodegeneration0.79272381
113MP0002572_abnormal_emotion/affect_behav0.79040974
114MP0009643_abnormal_urine_homeostasis0.78909502
115MP0002822_catalepsy0.78557704
116MP0005452_abnormal_adipose_tissue0.78109556
117MP0009745_abnormal_behavioral_response0.77839185
118MP0001984_abnormal_olfaction0.77632252
119MP0008057_abnormal_DNA_replication0.76673209
120MP0002928_abnormal_bile_duct0.76483337
121MP0003045_fibrosis0.76285705
122MP0001485_abnormal_pinna_reflex0.75585761
123MP0001293_anophthalmia0.73538126
124MP0003787_abnormal_imprinting0.72962568
125MP0002139_abnormal_hepatobiliary_system0.72617522
126MP0003937_abnormal_limbs/digits/tail_de0.72336186
127MP0000639_abnormal_adrenal_gland0.71731404
128MP0001756_abnormal_urination0.71630475
129MP0002063_abnormal_learning/memory/cond0.71092395
130MP0004924_abnormal_behavior0.70545782
131MP0005386_behavior/neurological_phenoty0.70545782
132MP0010307_abnormal_tumor_latency0.67004426
133MP0010094_abnormal_chromosome_stability0.66813725
134MP0002168_other_aberrant_phenotype0.66423646
135MP0006036_abnormal_mitochondrial_physio0.66319829
136MP0000955_abnormal_spinal_cord0.65606873
137MP0002736_abnormal_nociception_after0.65603019
138MP0010329_abnormal_lipoprotein_level0.65217100
139MP0003172_abnormal_lysosome_physiology0.64407566
140MP0004085_abnormal_heartbeat0.64405297
141MP0001666_abnormal_nutrient_absorption0.63864158
142MP0003718_maternal_effect0.63447377
143MP0002233_abnormal_nose_morphology0.63289012
144MP0003137_abnormal_impulse_conducting0.63061096
145MP0004885_abnormal_endolymph0.62939040
146MP0003880_abnormal_central_pattern0.62669246
147MP0000230_abnormal_systemic_arterial0.62319941
148MP0001186_pigmentation_phenotype0.62271652
149MP0003943_abnormal_hepatobiliary_system0.62262444
150MP0003186_abnormal_redox_activity0.61777789
151MP0001145_abnormal_male_reproductive0.61042713

Predicted human phenotypes

RankGene SetZ-score
1Osteomalacia (HP:0002749)6.23559914
2Symptomatic seizures (HP:0011145)5.71960644
3Abnormality of calcium-phosphate metabolism (HP:0100530)5.63829985
4Hypoglycemic seizures (HP:0002173)5.42732020
5Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.00607924
6Hyperinsulinemic hypoglycemia (HP:0000825)4.96130467
7Hyperglycemia (HP:0003074)4.55563582
8Hypoglycemic coma (HP:0001325)3.94051082
9Retinal atrophy (HP:0001105)3.90039336
10Insulin-resistant diabetes mellitus (HP:0000831)3.81799065
11Proximal tubulopathy (HP:0000114)3.76248361
12Hypokalemia (HP:0002900)3.70906116
13Hypoplasia of the fovea (HP:0007750)3.67238357
14Aplasia/Hypoplasia of the fovea (HP:0008060)3.67238357
15Ketosis (HP:0001946)3.62467418
16Abnormality of dentin (HP:0010299)3.48157076
17Prominent metopic ridge (HP:0005487)3.46980516
18Birth length less than 3rd percentile (HP:0003561)3.46881722
19Skin nodule (HP:0200036)3.34435927
20Abnormal pancreas size (HP:0012094)3.32328534
21Renal Fanconi syndrome (HP:0001994)3.29782540
22Congenital glaucoma (HP:0001087)3.29778489
23Hyperparathyroidism (HP:0000843)3.27367765
24Atelectasis (HP:0100750)3.15316107
25Hyperaldosteronism (HP:0000859)3.09227320
26Hyperphosphaturia (HP:0003109)2.98496737
27Cheilitis (HP:0100825)2.97639837
28Congenital malformation of the right heart (HP:0011723)2.93258174
29Double outlet right ventricle (HP:0001719)2.93258174
30Abnormality of the fovea (HP:0000493)2.93125758
31Methylmalonic acidemia (HP:0002912)2.92938013
32Abnormality of aromatic amino acid family metabolism (HP:0004338)2.88392437
33Abnormality of the metopic suture (HP:0005556)2.86715810
34Intestinal atresia (HP:0011100)2.84814581
35Pancreatic islet-cell hyperplasia (HP:0004510)2.82293780
36Decreased circulating renin level (HP:0003351)2.80460535
37Buphthalmos (HP:0000557)2.78369922
38Progressive macrocephaly (HP:0004481)2.72737905
39Atonic seizures (HP:0010819)2.72482936
40Hypothermia (HP:0002045)2.66736159
41Abnormality of potassium homeostasis (HP:0011042)2.64384455
42Dysostosis multiplex (HP:0000943)2.64311049
43Global brain atrophy (HP:0002283)2.61996878
44Large for gestational age (HP:0001520)2.59653447
45Enlarged penis (HP:0000040)2.58579863
46Hepatic necrosis (HP:0002605)2.57798988
47Hypomagnesemia (HP:0002917)2.57047805
48Abnormality of endocrine pancreas physiology (HP:0012093)2.55945785
49Abnormality of the pancreatic islet cells (HP:0006476)2.55945785
50Abnormality of midbrain morphology (HP:0002418)2.55589104
51Molar tooth sign on MRI (HP:0002419)2.55589104
52Agitation (HP:0000713)2.53788163
53Type II lissencephaly (HP:0007260)2.53568883
54Hyponatremia (HP:0002902)2.52467366
55Neoplasm of the adrenal cortex (HP:0100641)2.50502278
56Acute necrotizing encephalopathy (HP:0006965)2.49454058
57Late onset (HP:0003584)2.48405919
58Abnormal urine phosphate concentration (HP:0012599)2.48391753
59Tetany (HP:0001281)2.42709019
60Abnormality of the intrinsic pathway (HP:0010989)2.34183875
61Abnormality of vitamin B metabolism (HP:0004340)2.28580798
62EEG with generalized epileptiform discharges (HP:0011198)2.27463838
63Methylmalonic aciduria (HP:0012120)2.27192755
64Abnormality of renal resorption (HP:0011038)2.26689677
65Polydipsia (HP:0001959)2.25421043
66Abnormal drinking behavior (HP:0030082)2.25421043
67Ketoacidosis (HP:0001993)2.24971104
68Retinal dysplasia (HP:0007973)2.24258313
69Muscular hypotonia of the trunk (HP:0008936)2.23698150
70Hypsarrhythmia (HP:0002521)2.23626298
71Dysautonomia (HP:0002459)2.22671560
72Abnormality of the labia minora (HP:0012880)2.21953432
73Acute encephalopathy (HP:0006846)2.21588363
74Abdominal situs inversus (HP:0003363)2.18985490
75Abnormality of abdominal situs (HP:0011620)2.18985490
76Gout (HP:0001997)2.18877642
77Increased CSF lactate (HP:0002490)2.18232130
78Epileptiform EEG discharges (HP:0011182)2.18004059
79Abnormality of renin-angiotensin system (HP:0000847)2.17372915
80Hypophosphatemia (HP:0002148)2.16596486
81Abnormality of vitamin metabolism (HP:0100508)2.16264772
82Restlessness (HP:0000711)2.16165087
83Aplasia/Hypoplasia of the macula (HP:0008059)2.15529514
84Abnormality of magnesium homeostasis (HP:0004921)2.15355357
85Hyperphosphatemia (HP:0002905)2.14159156
86Tongue fasciculations (HP:0001308)2.13418690
87Sex reversal (HP:0012245)2.12588312
88Abnormal sex determination (HP:0012244)2.12588312
89Mitochondrial inheritance (HP:0001427)2.11467621
90Progressive neurologic deterioration (HP:0002344)2.09908894
91Neoplasm of the adrenal gland (HP:0100631)2.08581551
92Visual hallucinations (HP:0002367)2.07654882
93Downturned corners of mouth (HP:0002714)2.07385663
94Type I diabetes mellitus (HP:0100651)2.06885197
95Conjugated hyperbilirubinemia (HP:0002908)2.05329450
96Renal tubular acidosis (HP:0001947)2.05014183
97Papilledema (HP:0001085)2.04365235
98Pheochromocytoma (HP:0002666)2.04188431
99Neuroendocrine neoplasm (HP:0100634)2.03652426
100Adrenal hypoplasia (HP:0000835)2.01713018
101Chronic bronchitis (HP:0004469)2.01098956
102Abnormal mitochondria in muscle tissue (HP:0008316)2.01080483
103Pancreatic cysts (HP:0001737)2.00817050
104Increased circulating renin level (HP:0000848)1.96792210
105Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95942542
106Split foot (HP:0001839)1.94737723
107Dialeptic seizures (HP:0011146)1.94725000
108Congenital sensorineural hearing impairment (HP:0008527)1.93623440
109Cortical visual impairment (HP:0100704)1.92568030
110Broad face (HP:0000283)1.92398514
111Adrenal overactivity (HP:0002717)1.91315581
112Insulin resistance (HP:0000855)1.91028189
113Type I transferrin isoform profile (HP:0003642)1.90556135
114Neoplasm of the oral cavity (HP:0100649)1.90057097
115Glucose intolerance (HP:0000833)1.89803254
116Hepatocellular necrosis (HP:0001404)1.89591826
117Aplasia/Hypoplasia of the lens (HP:0008063)1.89509205
118Generalized aminoaciduria (HP:0002909)1.89429096
119Tachypnea (HP:0002789)1.89294642
120Abnormality of sodium homeostasis (HP:0010931)1.88274225
121Oligomenorrhea (HP:0000876)1.85921258
122Absence seizures (HP:0002121)1.85649186
123Pancreatic fibrosis (HP:0100732)1.85233760
124Urinary glycosaminoglycan excretion (HP:0003541)1.84453396
125Mucopolysacchariduria (HP:0008155)1.84453396
126Testicular neoplasm (HP:0010788)1.83033471
127Aqueductal stenosis (HP:0002410)1.82019178
128Prolonged partial thromboplastin time (HP:0003645)1.80023810
129Abnormal pupillary function (HP:0007686)1.79253543
130Abnormality of permanent molar morphology (HP:0011071)1.78741158
131Abnormality of the dental root (HP:0006486)1.78741158
132Taurodontia (HP:0000679)1.78741158
133Medial flaring of the eyebrow (HP:0010747)1.77928687
134Hepatoblastoma (HP:0002884)1.77643034
135Menstrual irregularities (HP:0000858)1.76469057
136Abnormal hair whorl (HP:0010721)1.75064418
137Hypokinesia (HP:0002375)1.73394390
138Muscle fibrillation (HP:0010546)1.70750857
139Cerebral edema (HP:0002181)1.68232320
140Rectal fistula (HP:0100590)1.67102690
141Rectovaginal fistula (HP:0000143)1.67102690
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.66817580
143Abnormality of methionine metabolism (HP:0010901)1.65746978
144Polyuria (HP:0000103)1.63320887
145Abnormality of urine glucose concentration (HP:0011016)1.63050497
146Glycosuria (HP:0003076)1.63050497
147Hematochezia (HP:0002573)1.61959287
148Respiratory failure (HP:0002878)1.61832198
149Megaloblastic anemia (HP:0001889)1.61460012
150Hemiparesis (HP:0001269)1.60194905
151Conjunctival hamartoma (HP:0100780)1.59609685
152Sensory axonal neuropathy (HP:0003390)1.57811526
153Increased hepatocellular lipid droplets (HP:0006565)1.57768755
154Poor suck (HP:0002033)1.57320594
155Hyperthyroidism (HP:0000836)1.53123932
156Disproportionate short-trunk short stature (HP:0003521)1.52916186
157Lipid accumulation in hepatocytes (HP:0006561)1.52482596
158Calf muscle hypertrophy (HP:0008981)1.52369176
159Congenital, generalized hypertrichosis (HP:0004540)1.51478239
160Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.50402337
161Decreased activity of mitochondrial respiratory chain (HP:0008972)1.50402337
162True hermaphroditism (HP:0010459)1.50389021
163Dicarboxylic aciduria (HP:0003215)1.48589280
164Abnormality of dicarboxylic acid metabolism (HP:0010995)1.48589280
165Aplasia/Hypoplasia of the sacrum (HP:0008517)1.47782565
166Abnormal biliary tract morphology (HP:0012440)1.47476720
167Abnormality of aspartate family amino acid metabolism (HP:0010899)1.46626931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.39779878
2PIK3CG4.23748695
3TAOK33.89872210
4AKT33.89699666
5NTRK33.69498259
6MST43.33737870
7FGFR23.22097875
8MAPK152.82455056
9PASK2.77638844
10PNCK2.61496488
11MAP4K22.42284139
12ZAK2.35120460
13BUB12.25587973
14MAP3K22.22163031
15HIPK22.18166735
16ARAF2.12824998
17IRAK32.11223808
18TRIM282.04306892
19ACVR1B2.00772635
20FRK1.93403727
21DAPK21.84125931
22BMPR21.80821315
23BRAF1.75432012
24EPHA21.73633201
25GRK11.72677618
26PHKG21.67652665
27PHKG11.67652665
28NME11.65483614
29STK31.61669099
30CDC42BPA1.60017765
31IRAK11.59313452
32STK161.47425321
33PLK21.46660390
34NTRK11.45795877
35PIK3CA1.43789472
36NUAK11.42531085
37ADRBK21.42428681
38GRK71.40046063
39NLK1.38271675
40IRAK21.35115153
41NEK61.32651063
42EIF2AK31.27578130
43MAP3K41.27057379
44PRKD31.24841808
45MARK11.23143483
46RPS6KA21.20054788
47STK41.19875281
48STK38L1.18408151
49UHMK11.15925597
50CSNK1G31.08914156
51MAP3K91.00160833
52BRSK21.00078000
53OXSR10.98597976
54MAP3K10.95173277
55PAK30.94860184
56PRKAA10.94121246
57VRK10.93852509
58TNIK0.92292571
59PRKCI0.91684857
60PINK10.90551781
61MKNK10.89666805
62SRPK10.88455488
63PLK10.86412872
64TLK10.85533276
65STK240.85230187
66ALK0.84549065
67RPS6KA50.84237480
68CAMKK20.84218632
69SCYL20.84070162
70TTK0.83215927
71DYRK30.80756864
72ERBB30.80500706
73STK390.80316526
74MAP2K60.78639981
75CDK30.78024429
76PRKCE0.76594928
77WNK40.76498912
78BCKDK0.75264957
79PRKAA20.74365419
80EPHA30.74216735
81FGFR30.71808809
82MET0.71063763
83FER0.70875162
84EIF2AK10.70312066
85MAP3K120.68015328
86SGK20.67120002
87NEK10.67030669
88WNK30.64874670
89TRPM70.63624277
90PLK30.62739216
91VRK20.62569612
92CSNK1E0.62452575
93PRKCG0.60975188
94BRSK10.60879970
95CAMK2D0.59354788
96CDC70.58367391
97SGK2230.57995210
98SGK4940.57995210
99RPS6KC10.57926864
100RPS6KL10.57926864
101ATM0.55910309
102DYRK20.53946682
103PBK0.53932043
104MKNK20.53725831
105FLT30.53097282
106WNK10.52509005
107ERBB40.51269366
108TIE10.50773011
109CASK0.50772839
110DAPK10.50341595
111CDK50.50277446
112NTRK20.49787225
113GRK50.49046376
114RPS6KB10.48924797
115ADRBK10.47734992
116CAMK1G0.47601480
117STK110.47217826
118MAP3K130.45762370
119CSNK1A1L0.45101417
120DYRK1A0.45091133
121PRKG20.43924771
122PRKACA0.43368221
123SGK10.42346715
124CAMK2B0.42019196
125CSNK1A10.41171823
126PRKCH0.39536820
127BCR0.38784583
128BMPR1B0.38717075
129IRAK40.37512694
130PLK40.37194180
131AURKA0.35994482
132PRKACG0.35896013
133PTK2B0.35795229
134WEE10.35208575
135KSR20.34833077
136PTK20.34164053
137RPS6KA60.32695925
138CAMK2A0.32671747
139CSNK2A20.32610747
140CSNK1G10.32423555
141RET0.31943607
142TGFBR10.31804745
143RPS6KA40.31450329
144CSNK1G20.31317879
145FGFR10.30978295
146TSSK60.30858498
147MAP2K10.30697098
148MAP2K70.30009957
149YES10.29851688
150EIF2AK20.28475365

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.80847700
2Protein export_Homo sapiens_hsa030605.94688810
3Sulfur metabolism_Homo sapiens_hsa009203.07431717
4Insulin secretion_Homo sapiens_hsa049112.62642837
5Fatty acid elongation_Homo sapiens_hsa000622.58463577
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50560739
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.49739263
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.31779662
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21570343
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.21568438
11Folate biosynthesis_Homo sapiens_hsa007902.10993121
12Vibrio cholerae infection_Homo sapiens_hsa051101.93937018
13Type II diabetes mellitus_Homo sapiens_hsa049301.74124572
14Steroid biosynthesis_Homo sapiens_hsa001001.72992277
15Oxidative phosphorylation_Homo sapiens_hsa001901.71402198
16Collecting duct acid secretion_Homo sapiens_hsa049661.67489651
17Vitamin B6 metabolism_Homo sapiens_hsa007501.62727079
18Regulation of autophagy_Homo sapiens_hsa041401.61482944
19Propanoate metabolism_Homo sapiens_hsa006401.58769206
20Taste transduction_Homo sapiens_hsa047421.55701579
21Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.50744020
22N-Glycan biosynthesis_Homo sapiens_hsa005101.43454275
23GABAergic synapse_Homo sapiens_hsa047271.40471773
24Tryptophan metabolism_Homo sapiens_hsa003801.39661312
25Amphetamine addiction_Homo sapiens_hsa050311.37903991
26Circadian rhythm_Homo sapiens_hsa047101.37560532
27Type I diabetes mellitus_Homo sapiens_hsa049401.35826000
28Proteasome_Homo sapiens_hsa030501.34928824
29Mismatch repair_Homo sapiens_hsa034301.32622973
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32149124
31Fatty acid metabolism_Homo sapiens_hsa012121.31323963
32Non-homologous end-joining_Homo sapiens_hsa034501.28999054
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27267288
34Peroxisome_Homo sapiens_hsa041461.25421264
35Nicotine addiction_Homo sapiens_hsa050331.24458540
36Homologous recombination_Homo sapiens_hsa034401.23654732
37Synaptic vesicle cycle_Homo sapiens_hsa047211.20031440
38Cocaine addiction_Homo sapiens_hsa050301.20015310
39Phototransduction_Homo sapiens_hsa047441.19834079
40RNA degradation_Homo sapiens_hsa030181.16962250
41RNA polymerase_Homo sapiens_hsa030201.15445590
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.12279977
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12105902
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10826058
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09772654
46Fatty acid degradation_Homo sapiens_hsa000711.07973171
47Lysosome_Homo sapiens_hsa041421.03944657
48Parkinsons disease_Homo sapiens_hsa050121.03341916
49Morphine addiction_Homo sapiens_hsa050321.02732335
50Prion diseases_Homo sapiens_hsa050201.01041333
51Serotonergic synapse_Homo sapiens_hsa047260.96697780
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96111764
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94918739
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94587864
55beta-Alanine metabolism_Homo sapiens_hsa004100.93704817
56Fanconi anemia pathway_Homo sapiens_hsa034600.93626512
57Glutathione metabolism_Homo sapiens_hsa004800.93244143
58Alzheimers disease_Homo sapiens_hsa050100.92267047
59Inositol phosphate metabolism_Homo sapiens_hsa005620.91309622
60Linoleic acid metabolism_Homo sapiens_hsa005910.89204342
61Sphingolipid metabolism_Homo sapiens_hsa006000.87102669
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86946606
63Huntingtons disease_Homo sapiens_hsa050160.83961805
64Phosphatidylinositol signaling system_Homo sapiens_hsa040700.83542979
65Pyruvate metabolism_Homo sapiens_hsa006200.83093904
66Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82366884
67Dopaminergic synapse_Homo sapiens_hsa047280.81162104
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80768213
69Circadian entrainment_Homo sapiens_hsa047130.80469033
70Basal transcription factors_Homo sapiens_hsa030220.77751226
71Thyroid hormone synthesis_Homo sapiens_hsa049180.76808746
72Pancreatic secretion_Homo sapiens_hsa049720.76482386
73One carbon pool by folate_Homo sapiens_hsa006700.76086528
74Galactose metabolism_Homo sapiens_hsa000520.75866389
75Long-term potentiation_Homo sapiens_hsa047200.75456581
76Other glycan degradation_Homo sapiens_hsa005110.74912451
77Selenocompound metabolism_Homo sapiens_hsa004500.73757671
78Cholinergic synapse_Homo sapiens_hsa047250.70877933
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.70657658
80Alcoholism_Homo sapiens_hsa050340.68869269
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67389387
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.66442961
83Pyrimidine metabolism_Homo sapiens_hsa002400.66101016
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65953551
85Glucagon signaling pathway_Homo sapiens_hsa049220.64498526
86Oocyte meiosis_Homo sapiens_hsa041140.63876476
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63056737
88Estrogen signaling pathway_Homo sapiens_hsa049150.62773824
89Mineral absorption_Homo sapiens_hsa049780.61191992
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.60363990
91RNA transport_Homo sapiens_hsa030130.59956604
92Long-term depression_Homo sapiens_hsa047300.58873406
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.58289715
94Fructose and mannose metabolism_Homo sapiens_hsa000510.57580974
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.57518221
96Dorso-ventral axis formation_Homo sapiens_hsa043200.56796803
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55890605
98Renin secretion_Homo sapiens_hsa049240.55632892
99Nucleotide excision repair_Homo sapiens_hsa034200.55461424
100Retinol metabolism_Homo sapiens_hsa008300.54502532
1012-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.51663013
102Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51151781
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51036530
104Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50010677
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48946133
106Glutamatergic synapse_Homo sapiens_hsa047240.47020065
107Ether lipid metabolism_Homo sapiens_hsa005650.47011115
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46277081
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.45679800
110Olfactory transduction_Homo sapiens_hsa047400.45121288
111Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44977211
112Purine metabolism_Homo sapiens_hsa002300.43929140
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43336321
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42910958
115Arachidonic acid metabolism_Homo sapiens_hsa005900.42030157
116DNA replication_Homo sapiens_hsa030300.42003856
117Cardiac muscle contraction_Homo sapiens_hsa042600.41716290
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41073688
119TGF-beta signaling pathway_Homo sapiens_hsa043500.39797840
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39633325
121Gastric acid secretion_Homo sapiens_hsa049710.39477618
122Glycerophospholipid metabolism_Homo sapiens_hsa005640.38998188
123Ovarian steroidogenesis_Homo sapiens_hsa049130.38571024
124Insulin signaling pathway_Homo sapiens_hsa049100.38051631
125Prolactin signaling pathway_Homo sapiens_hsa049170.36561029
126Metabolic pathways_Homo sapiens_hsa011000.35462632
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33695772
128Chemical carcinogenesis_Homo sapiens_hsa052040.33456539
129Hedgehog signaling pathway_Homo sapiens_hsa043400.33177411
130Insulin resistance_Homo sapiens_hsa049310.32632805
131Base excision repair_Homo sapiens_hsa034100.32394453
132AMPK signaling pathway_Homo sapiens_hsa041520.32203670
133Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31934170
134Prostate cancer_Homo sapiens_hsa052150.31848228
135Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31165927
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30725479
137Arginine and proline metabolism_Homo sapiens_hsa003300.30376219
138Starch and sucrose metabolism_Homo sapiens_hsa005000.29398516
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.29224875
140Vitamin digestion and absorption_Homo sapiens_hsa049770.28941812
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28844827
142Melanogenesis_Homo sapiens_hsa049160.26130948
143ABC transporters_Homo sapiens_hsa020100.26051218
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24955102
145Butanoate metabolism_Homo sapiens_hsa006500.24800962
146cAMP signaling pathway_Homo sapiens_hsa040240.23721673
147Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23555684

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