FAM160A2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the FTS/Hook/FHIP (FHF) complex, which can interact with members of the homotypic vesicular protein sorting (HOPS) complex. This interaction suggests that the encoded protein is involved in vesicle trafficking. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.66938537
2positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.30656157
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.23963871
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.21828790
5synaptic vesicle maturation (GO:0016188)5.19911567
6vocalization behavior (GO:0071625)5.19380125
7locomotory exploration behavior (GO:0035641)5.12403545
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.92302945
9negative regulation of cell killing (GO:0031342)4.92302945
10cellular extravasation (GO:0045123)4.76090291
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.72187146
12synaptic vesicle exocytosis (GO:0016079)4.69915200
13glutamate secretion (GO:0014047)4.68354396
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.64236713
15antigen processing and presentation of endogenous antigen (GO:0019883)4.62600489
16protein localization to synapse (GO:0035418)4.54090713
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.51673872
18positive regulation of synapse maturation (GO:0090129)4.45526799
19detection of other organism (GO:0098543)4.44695087
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.43242217
21detection of bacterium (GO:0016045)4.40628690
22positive regulation of gamma-delta T cell activation (GO:0046645)4.29266687
23regulation of synaptic vesicle exocytosis (GO:2000300)4.25932550
24regulation of glutamate receptor signaling pathway (GO:1900449)4.23594585
25exploration behavior (GO:0035640)4.20679328
26layer formation in cerebral cortex (GO:0021819)4.16027755
27negative regulation of erythrocyte differentiation (GO:0045647)4.10596545
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09248486
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.09248486
30modulation by symbiont of host immune response (GO:0052553)4.09248486
31positive regulation by symbiont of host defense response (GO:0052509)4.09248486
32modulation by symbiont of host defense response (GO:0052031)4.09248486
33modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09248486
34response to peptidoglycan (GO:0032494)3.96133733
35neutrophil activation involved in immune response (GO:0002283)3.92431219
36regulation of synaptic vesicle transport (GO:1902803)3.87595777
37ionotropic glutamate receptor signaling pathway (GO:0035235)3.86767610
38neurotransmitter secretion (GO:0007269)3.85924766
39regulation of long-term neuronal synaptic plasticity (GO:0048169)3.81265994
40regulation of neuronal synaptic plasticity (GO:0048168)3.71873599
41leukocyte aggregation (GO:0070486)3.68187797
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67172296
43synaptic transmission, glutamatergic (GO:0035249)3.66918501
44proline transport (GO:0015824)3.65487022
45regulation of clathrin-mediated endocytosis (GO:2000369)3.65197408
46cellular potassium ion homeostasis (GO:0030007)3.63361001
47macrophage activation involved in immune response (GO:0002281)3.61238465
48detection of external biotic stimulus (GO:0098581)3.58413796
49cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.57332721
50response to pheromone (GO:0019236)3.57314745
51cerebellar Purkinje cell differentiation (GO:0021702)3.54951067
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.53931945
53neuron cell-cell adhesion (GO:0007158)3.52582374
54regulation of synapse structural plasticity (GO:0051823)3.51891615
55neurotransmitter-gated ion channel clustering (GO:0072578)3.50320746
56regulation of gamma-delta T cell activation (GO:0046643)3.48116965
57sodium ion export (GO:0071436)3.46298579
58dendritic spine morphogenesis (GO:0060997)3.46056412
59neuromuscular process controlling balance (GO:0050885)3.42607635
60glutamate receptor signaling pathway (GO:0007215)3.38906568
61synaptic vesicle endocytosis (GO:0048488)3.35916480
62cell communication by electrical coupling (GO:0010644)3.35781478
63response to histamine (GO:0034776)3.35379182
64positive regulation of membrane potential (GO:0045838)3.35297723
65neuron-neuron synaptic transmission (GO:0007270)3.34300790
66mannose metabolic process (GO:0006013)3.33933061
67regulation of excitatory postsynaptic membrane potential (GO:0060079)3.32708820
68axonal fasciculation (GO:0007413)3.29902906
69response to muramyl dipeptide (GO:0032495)3.28977780
70regulation of postsynaptic membrane potential (GO:0060078)3.27175973
71long-term memory (GO:0007616)3.26695368
72microglial cell activation (GO:0001774)3.26018155
73chemosensory behavior (GO:0007635)3.24585156
74establishment of nucleus localization (GO:0040023)3.23824940
75positive regulation of vesicle fusion (GO:0031340)3.23269933
76membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.23221623
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.22286706
78negative regulation of lymphocyte mediated immunity (GO:0002707)3.21361504
79regulation of gamma-delta T cell differentiation (GO:0045586)3.17577063
80regulation of mast cell degranulation (GO:0043304)3.16764762
81regulation of interferon-beta biosynthetic process (GO:0045357)3.16680968
82neuronal action potential propagation (GO:0019227)3.15593997
83detection of biotic stimulus (GO:0009595)3.12506429
84regulation of myeloid leukocyte mediated immunity (GO:0002886)3.11513149
85regulation of synaptic plasticity (GO:0048167)3.11020273
86angiotensin maturation (GO:0002003)3.10756021
87regulation of leukocyte degranulation (GO:0043300)3.10690805
88innervation (GO:0060384)3.09021339
89respiratory burst (GO:0045730)3.08675714
90neutrophil mediated immunity (GO:0002446)3.08429751
91membrane depolarization during action potential (GO:0086010)3.05148963
92G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.04537198
93pre-miRNA processing (GO:0031054)3.04263003
94negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04110353
95gamma-aminobutyric acid transport (GO:0015812)3.02216858
96activation of protein kinase A activity (GO:0034199)3.01906564
97macrophage activation (GO:0042116)3.01657890
98germinal center formation (GO:0002467)3.01319282
99positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.00610843
100regulation of dendritic spine morphogenesis (GO:0061001)3.00277158
101regulation of synapse maturation (GO:0090128)2.99104576
102detection of molecule of bacterial origin (GO:0032490)2.98530811
103neuron recognition (GO:0008038)2.98260570
104cell communication involved in cardiac conduction (GO:0086065)2.97043872
105vesicle transport along microtubule (GO:0047496)2.96384618
106neutrophil activation (GO:0042119)2.95692336
107neurotransmitter transport (GO:0006836)2.93772863
108immunoglobulin mediated immune response (GO:0016064)2.93571722
109positive regulation of dendritic spine morphogenesis (GO:0061003)2.89623605
110negative regulation of leukocyte mediated immunity (GO:0002704)2.89184699
111gamma-aminobutyric acid signaling pathway (GO:0007214)2.88950097
112long-term synaptic potentiation (GO:0060291)2.88418712
113positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.88306412
114positive regulation of histone deacetylation (GO:0031065)2.88208147
115cell migration in hindbrain (GO:0021535)2.86467150
116membrane hyperpolarization (GO:0060081)2.84952349
117regulation of mast cell activation involved in immune response (GO:0033006)2.83354652
118N-acetylneuraminate metabolic process (GO:0006054)2.83063227
119cytoskeletal anchoring at plasma membrane (GO:0007016)2.81607586
120regulation of vesicle fusion (GO:0031338)2.80890427
121regulation of B cell receptor signaling pathway (GO:0050855)2.80554996
122response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.78517142
123response to host immune response (GO:0052572)2.78517142
124regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.78480582
125dendritic spine organization (GO:0097061)2.77150684
126negative regulation of interleukin-8 production (GO:0032717)2.76852517
127positive regulation of neurotransmitter transport (GO:0051590)2.76312991
128regulation of ARF protein signal transduction (GO:0032012)2.74844443
129regulation of chemokine biosynthetic process (GO:0045073)2.74466981
130regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74203773
131negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73740724
132granulocyte activation (GO:0036230)2.73719485
133long term synaptic depression (GO:0060292)2.73697520
134regulation of synaptic transmission, glutamatergic (GO:0051966)2.72335091
135peptide catabolic process (GO:0043171)2.71921040
136social behavior (GO:0035176)2.71764156
137intraspecies interaction between organisms (GO:0051703)2.71764156
138membrane depolarization (GO:0051899)2.71605304
139regulation of neurotransmitter secretion (GO:0046928)2.71286318
140positive regulation of synaptic transmission, GABAergic (GO:0032230)2.71081315
141positive regulation of Cdc42 GTPase activity (GO:0043089)2.70016522
142disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.69970338
143killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.69970338
144positive regulation of neurotransmitter secretion (GO:0001956)2.69790477
145behavioral fear response (GO:0001662)2.69299736
146behavioral defense response (GO:0002209)2.69299736
147dendrite morphogenesis (GO:0048813)2.69123624
148negative regulation of interleukin-12 production (GO:0032695)2.68798804
149auditory behavior (GO:0031223)2.68693367
150response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.68026309
151response to host (GO:0075136)2.68026309
152response to host defenses (GO:0052200)2.68026309
153regulation of neurotransmitter levels (GO:0001505)2.66919841
154negative thymic T cell selection (GO:0045060)2.66847065
155suckling behavior (GO:0001967)2.65895343
156positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.65248907
157organelle transport along microtubule (GO:0072384)2.65034097
158synapse assembly (GO:0007416)2.64315918
159regulation of calcium ion-dependent exocytosis (GO:0017158)2.64193313
160central nervous system projection neuron axonogenesis (GO:0021952)2.64189989
161mating behavior (GO:0007617)2.63566866
162neuromuscular process (GO:0050905)2.63033486
163regulation of regulated secretory pathway (GO:1903305)2.62481994
164regulation of tolerance induction (GO:0002643)2.62211320
165negative regulation of T cell mediated immunity (GO:0002710)2.60525922
166signal complex assembly (GO:0007172)2.60261234
167regulation of T-helper 2 cell differentiation (GO:0045628)2.59812127
168positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.59367383
169stress granule assembly (GO:0034063)2.59213994
170antigen processing and presentation via MHC class Ib (GO:0002475)2.58372298
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.58010441
172leukocyte migration involved in inflammatory response (GO:0002523)2.55775665
173negative regulation of type 2 immune response (GO:0002829)2.55693852
174response to type I interferon (GO:0034340)2.54357363
175type I interferon signaling pathway (GO:0060337)2.53963570
176cellular response to type I interferon (GO:0071357)2.53963570
177myeloid cell activation involved in immune response (GO:0002275)2.51991555
178NIK/NF-kappaB signaling (GO:0038061)2.51443504
179positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.50668423
180regulation of T cell tolerance induction (GO:0002664)2.50570227
181myeloid leukocyte mediated immunity (GO:0002444)2.50265671
182response to laminar fluid shear stress (GO:0034616)2.50094780
183positive regulation of protein deacetylation (GO:0090312)2.50010897
184negative regulation of innate immune response (GO:0045824)2.49464915
185positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.49106484
186regulation of cellular extravasation (GO:0002691)2.48620012
187leukotriene metabolic process (GO:0006691)2.47978602
188lipopolysaccharide-mediated signaling pathway (GO:0031663)2.47478221
189positive regulation of mast cell activation (GO:0033005)2.46785313
190positive thymic T cell selection (GO:0045059)2.46571381
191positive regulation of chemokine biosynthetic process (GO:0045080)2.45127716
192B cell receptor signaling pathway (GO:0050853)2.44975410
193negative T cell selection (GO:0043383)2.44584446
194positive regulation of cellular amide metabolic process (GO:0034250)2.44446000
195defense response to protozoan (GO:0042832)2.43446376
196negative regulation of growth of symbiont in host (GO:0044130)2.41758178
197negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.41758178
198modulation of growth of symbiont involved in interaction with host (GO:0044144)2.41758178
199regulation of growth of symbiont in host (GO:0044126)2.41758178

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.22342141
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.22402677
3VDR_21846776_ChIP-Seq_THP-1_Human3.06837257
4DROSHA_22980978_ChIP-Seq_HELA_Human2.98602802
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.94065165
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.88662198
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65832201
8GBX2_23144817_ChIP-Seq_PC3_Human2.60424879
9REST_21632747_ChIP-Seq_MESCs_Mouse2.59605963
10VDR_24763502_ChIP-Seq_THP-1_Human2.50020395
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.47011378
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46964658
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46206264
14SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.37435384
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.34743507
16TCF7_22412390_ChIP-Seq_EML_Mouse2.26283537
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22628333
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.21244809
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.19575518
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18950851
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16120071
22MYC_22102868_ChIP-Seq_BL_Human2.11241694
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.08830972
24JARID2_20064375_ChIP-Seq_MESCs_Mouse2.08468302
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.08011514
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.07573712
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.04463385
28NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.04160053
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.03195404
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.99148598
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.99148598
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98872215
33NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98637772
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.96568160
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96306703
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.93749093
37* MAF_26560356_Chip-Seq_TH1_Human1.91095851
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.90980946
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90303307
40* IRF8_27001747_Chip-Seq_BMDM_Mouse1.90160865
41SCL_19346495_ChIP-Seq_HPC-7_Human1.87021551
42MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.85195002
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.85059001
44SPI1_23127762_ChIP-Seq_K562_Human1.83465191
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.83417681
46IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82899346
47KDM2B_26808549_Chip-Seq_K562_Human1.78480910
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.77194720
49UTX_26944678_Chip-Seq_JUKART_Human1.76014665
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.75360506
51MYB_21317192_ChIP-Seq_ERMYB_Mouse1.74019133
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.73836364
53ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.73569150
54SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73310715
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.72719877
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70920683
57SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67439522
58KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66576353
59ZFP281_27345836_Chip-Seq_ESCs_Mouse1.66524057
60EZH2_27294783_Chip-Seq_ESCs_Mouse1.65975163
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.64950179
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64764145
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63053847
64RACK7_27058665_Chip-Seq_MCF-7_Human1.62949031
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.61974533
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60771670
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57781212
68FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.56071220
69GATA1_19941827_ChIP-Seq_MEL_Mouse1.55555532
70SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55316854
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.54498489
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54319627
73RUNX_20019798_ChIP-Seq_JUKART_Human1.52838104
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.51714095
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.50777600
76MAF_26560356_Chip-Seq_TH2_Human1.50739218
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.50652497
78SPI1_23547873_ChIP-Seq_NB4_Human1.50223151
79ZNF274_21170338_ChIP-Seq_K562_Hela1.49690187
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.44045472
81TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43357556
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42727319
83PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41831153
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.40566632
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38967367
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.38433377
87PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.38196207
88BCL6_27268052_Chip-Seq_Bcells_Human1.38180817
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.38087923
90WT1_25993318_ChIP-Seq_PODOCYTE_Human1.37832962
91AR_19668381_ChIP-Seq_PC3_Human1.37505700
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37281680
93GATA1_19941826_ChIP-Seq_K562_Human1.37016968
94CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36973509
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36592863
96CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36100481
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35946781
98ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35024158
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.33963876
100EED_16625203_ChIP-ChIP_MESCs_Mouse1.33317593
101ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.32967623
102BCOR_27268052_Chip-Seq_Bcells_Human1.32867358
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32081183
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31042431
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30576707
106MYB_26560356_Chip-Seq_TH1_Human1.30377271
107STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30143868
108P68_20966046_ChIP-Seq_HELA_Human1.29793426
109Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.29486142
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29127497
111TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28986151
112RING1B_27294783_Chip-Seq_ESCs_Mouse1.26710875
113KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25927511
114SA1_27219007_Chip-Seq_ERYTHROID_Human1.25426713
115MYB_26560356_Chip-Seq_TH2_Human1.25005551
116SOX2_21211035_ChIP-Seq_LN229_Gbm1.23640700
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23259206
118VDR_24787735_ChIP-Seq_THP-1_Human1.22251094
119SMAD4_21799915_ChIP-Seq_A2780_Human1.21399874
120GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20386164
121FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20169235
122PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19433170
123AR_21572438_ChIP-Seq_LNCaP_Human1.19264108
124DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18604432
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18552407
126NCOR1_26117541_ChIP-Seq_K562_Human1.18438897
127RING1B_27294783_Chip-Seq_NPCs_Mouse1.18014633
128ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17875073
129SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16242578
130CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15129356
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13363200
132GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11901129
133RUNX1_27514584_Chip-Seq_MCF-7_Human1.11242054
134ELF1_20517297_ChIP-Seq_JURKAT_Human1.10645528
135TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.10399067
136GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09841125
137AHR_22903824_ChIP-Seq_MCF-7_Human1.09713624
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.09630741
139SMAD3_21741376_ChIP-Seq_HESCs_Human1.09584425
140CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08754146
141RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08085245
142TET1_21490601_ChIP-Seq_MESCs_Mouse1.07726394
143CTNNB1_20460455_ChIP-Seq_HCT116_Human1.07499235
144CREB1_26743006_Chip-Seq_LNCaP_Human1.06751542
145SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04752170
146KDM2B_26808549_Chip-Seq_SUP-B15_Human1.04497662
147LXR_22292898_ChIP-Seq_THP-1_Human1.04203108
148STAT3_23295773_ChIP-Seq_U87_Human1.04160920
149SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03764416
150HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03636314
151CTCF_27219007_Chip-Seq_Bcells_Human1.03563717
152KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03523515
153PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03073799
154TP53_16413492_ChIP-PET_HCT116_Human1.02505644
155TET1_21451524_ChIP-Seq_MESCs_Mouse1.02123334
156LXR_22158963_ChIP-Seq_LIVER_Mouse1.01957186
157P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01364926
158UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00929323
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00765633
160TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00679867
161KDM2B_26808549_Chip-Seq_DND41_Human1.00265648
162SMAD3_21741376_ChIP-Seq_EPCs_Human0.99357263
163ARNT_22903824_ChIP-Seq_MCF-7_Human0.96832591
164SMAD4_21741376_ChIP-Seq_HESCs_Human0.96663338
165SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96368273
166STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96005362
167ESR2_21235772_ChIP-Seq_MCF-7_Human0.95950213
168NR3C1_23031785_ChIP-Seq_PC12_Mouse0.95550743
169SMC4_20622854_ChIP-Seq_HELA_Human0.95464173
170ISL1_27105846_Chip-Seq_CPCs_Mouse0.92993961
171OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91951933
172AR_25329375_ChIP-Seq_VCAP_Human0.91524016
173KDM2B_26808549_Chip-Seq_JURKAT_Human0.90533249
174TCF4_23295773_ChIP-Seq_U87_Human0.90373224
175VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.89876168
176RXR_22108803_ChIP-Seq_LS180_Human0.89645161
177SMAD3_21741376_ChIP-Seq_ESCs_Human0.89388608
178* KLF4_19829295_ChIP-Seq_ESCs_Human0.89302834
179ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87976607
180TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87259219
181CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87106051
182ESR1_20079471_ChIP-ChIP_T-47D_Human0.86219719
183WDR5_24793694_ChIP-Seq_LNCAP_Human0.85975995

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.07883238
2MP0003436_decreased_susceptibility_to4.00127719
3MP0003635_abnormal_synaptic_transmissio3.74403860
4MP0003303_peritoneal_inflammation3.65082412
5MP0004270_analgesia3.36127927
6MP0003724_increased_susceptibility_to3.34543434
7MP0010234_abnormal_vibrissa_follicle3.31753727
8MP0003880_abnormal_central_pattern3.30914782
9MP0003283_abnormal_digestive_organ2.96784749
10MP0002063_abnormal_learning/memory/cond2.93247461
11MP0001835_abnormal_antigen_presentation2.75991559
12MP0009745_abnormal_behavioral_response2.66681082
13MP0002419_abnormal_innate_immunity2.65297802
14MP0002064_seizures2.52140365
15MP0005025_abnormal_response_to2.50614591
16MP0001968_abnormal_touch/_nociception2.49836957
17MP0000569_abnormal_digit_pigmentation2.49015942
18MP0003191_abnormal_cellular_cholesterol2.45983147
19MP0002822_catalepsy2.43749525
20MP0009046_muscle_twitch2.35307800
21MP0005451_abnormal_body_composition2.35181906
22MP0003300_gastrointestinal_ulcer2.32614598
23MP0002572_abnormal_emotion/affect_behav2.31296929
24MP0009785_altered_susceptibility_to2.30416361
25MP0010155_abnormal_intestine_physiology2.30231323
26MP0002653_abnormal_ependyma_morphology2.24629150
27MP0005360_urolithiasis2.23153617
28MP0005387_immune_system_phenotype2.21813664
29MP0001790_abnormal_immune_system2.21813664
30MP0005000_abnormal_immune_tolerance2.19404232
31MP0009780_abnormal_chondrocyte_physiolo2.18985990
32MP0003172_abnormal_lysosome_physiology2.17427194
33MP0001800_abnormal_humoral_immune2.14409101
34MP0001486_abnormal_startle_reflex2.06580513
35MP0005058_abnormal_lysosome_morphology2.01878601
36MP0002734_abnormal_mechanical_nocicepti2.01555997
37MP0004947_skin_inflammation2.00916043
38MP0005083_abnormal_biliary_tract2.00315576
39MP0006082_CNS_inflammation1.96473406
40MP0004858_abnormal_nervous_system1.94480089
41MP0001533_abnormal_skeleton_physiology1.93759414
42MP0005365_abnormal_bile_salt1.92718639
43MP0002420_abnormal_adaptive_immunity1.92039925
44MP0001819_abnormal_immune_cell1.91467729
45MP0000685_abnormal_immune_system1.91119235
46MP0002723_abnormal_immune_serum1.89482450
47MP0002735_abnormal_chemical_nociception1.89254120
48MP0002452_abnormal_antigen_presenting1.88980609
49MP0005423_abnormal_somatic_nervous1.88655495
50MP0008260_abnormal_autophagy1.86928433
51MP0009840_abnormal_foam_cell1.86491264
52MP0005671_abnormal_response_to1.83972041
53MP0002272_abnormal_nervous_system1.83668160
54MP0001501_abnormal_sleep_pattern1.82581336
55MP0002909_abnormal_adrenal_gland1.78389045
56MP0002736_abnormal_nociception_after1.77286059
57MP0003763_abnormal_thymus_physiology1.75518570
58MP0002733_abnormal_thermal_nociception1.74998990
59MP0005085_abnormal_gallbladder_physiolo1.71825541
60MP0002234_abnormal_pharynx_morphology1.68642178
61MP0004811_abnormal_neuron_physiology1.67044869
62MP0008961_abnormal_basal_metabolism1.62999965
63MP0002148_abnormal_hypersensitivity_rea1.62261561
64MP0002139_abnormal_hepatobiliary_system1.61752482
65MP0009278_abnormal_bone_marrow1.60082352
66MP0003866_abnormal_defecation1.58283779
67MP0004264_abnormal_extraembryonic_tissu1.56444335
68MP0002557_abnormal_social/conspecific_i1.56289501
69MP0002405_respiratory_system_inflammati1.55566431
70MP0001845_abnormal_inflammatory_respons1.55149459
71MP0001881_abnormal_mammary_gland1.53551461
72MP0003787_abnormal_imprinting1.51424882
73MP0003828_pulmonary_edema1.50798678
74MP0002067_abnormal_sensory_capabilities1.49692033
75MP0000465_gastrointestinal_hemorrhage1.49557444
76MP0003879_abnormal_hair_cell1.48937835
77MP0001440_abnormal_grooming_behavior1.46879908
78MP0008569_lethality_at_weaning1.46151389
79MP0001970_abnormal_pain_threshold1.45608968
80MP0002184_abnormal_innervation1.44210418
81MP0005464_abnormal_platelet_physiology1.42491504
82MP0009333_abnormal_splenocyte_physiolog1.39899747
83MP0000716_abnormal_immune_system1.39695917
84MP0003123_paternal_imprinting1.39676015
85MP0002998_abnormal_bone_remodeling1.37714735
86MP0000778_abnormal_nervous_system1.35504618
87MP0004924_abnormal_behavior1.35075330
88MP0005386_behavior/neurological_phenoty1.35075330
89MP0008004_abnormal_stomach_pH1.35035045
90MP0000955_abnormal_spinal_cord1.32912035
91MP0001849_ear_inflammation1.32090374
92MP0002398_abnormal_bone_marrow1.30848771
93MP0003329_amyloid_beta_deposits1.30703303
94MP0003890_abnormal_embryonic-extraembry1.29596444
95MP0002132_abnormal_respiratory_system1.29397993
96MP0003119_abnormal_digestive_system1.29076453
97MP0001873_stomach_inflammation1.27937150
98MP0000858_altered_metastatic_potential1.27159894
99MP0008469_abnormal_protein_level1.26645210
100MP0005166_decreased_susceptibility_to1.24565957
101MP0004885_abnormal_endolymph1.20023214
102MP0002882_abnormal_neuron_morphology1.19754483
103MP0005670_abnormal_white_adipose1.19230985
104MP0001851_eye_inflammation1.18503004
105MP0005310_abnormal_salivary_gland1.17289799
106MP0003075_altered_response_to1.15629380
107MP0005666_abnormal_adipose_tissue1.15336780
108MP0002152_abnormal_brain_morphology1.15084769
109MP0001545_abnormal_hematopoietic_system1.13701220
110MP0005397_hematopoietic_system_phenotyp1.13701220
111MP0004233_abnormal_muscle_weight1.13599618
112MP0009764_decreased_sensitivity_to1.13474525
113MP0004510_myositis1.12882213
114MP0002722_abnormal_immune_system1.12297601
115MP0000604_amyloidosis1.09575060
116MP0002429_abnormal_blood_cell1.07977997
117MP0002066_abnormal_motor_capabilities/c1.06822463
118MP0003690_abnormal_glial_cell1.06794236
119MP0001663_abnormal_digestive_system1.06266249
120MP0001502_abnormal_circadian_rhythm1.06190229
121MP0005187_abnormal_penis_morphology1.05832711
122MP0002138_abnormal_hepatobiliary_system1.05058451
123MP0005409_darkened_coat_color1.04871283
124MP0005499_abnormal_olfactory_system1.04562095
125MP0005394_taste/olfaction_phenotype1.04562095
126MP0001984_abnormal_olfaction1.04534776
127MP0004133_heterotaxia1.04226735
128MP0003252_abnormal_bile_duct1.00048595
129MP0000689_abnormal_spleen_morphology0.99469052
130MP0003091_abnormal_cell_migration0.98280094
131MP0002396_abnormal_hematopoietic_system0.97382941
132MP0008872_abnormal_physiological_respon0.96639963
133MP0009115_abnormal_fat_cell0.95412964
134MP0005164_abnormal_response_to0.95103216
135MP0003453_abnormal_keratinocyte_physiol0.95020188
136MP0010329_abnormal_lipoprotein_level0.94584022
137MP0005375_adipose_tissue_phenotype0.91704791
138MP0005167_abnormal_blood-brain_barrier0.91612646
139MP0002166_altered_tumor_susceptibility0.91200755
140MP0003633_abnormal_nervous_system0.90939094
141MP0003861_abnormal_nervous_system0.90742424
142MP0000678_abnormal_parathyroid_gland0.90684963
143MP0000490_abnormal_crypts_of0.90682383
144MP0000249_abnormal_blood_vessel0.90147426
145MP0001664_abnormal_digestion0.89830995
146MP0002089_abnormal_postnatal_growth/wei0.89244015
147MP0003183_abnormal_peptide_metabolism0.89135056
148MP0000703_abnormal_thymus_morphology0.88580758
149MP0004883_abnormal_blood_vessel0.88543310
150MP0005645_abnormal_hypothalamus_physiol0.88366642
151MP0003122_maternal_imprinting0.88356981
152MP0002009_preneoplasia0.88187500
153MP0002933_joint_inflammation0.87849088
154MP0002069_abnormal_eating/drinking_beha0.86839212
155MP0002971_abnormal_brown_adipose0.86336347
156MP0000609_abnormal_liver_physiology0.85342496
157MP0000003_abnormal_adipose_tissue0.84028907
158MP0005076_abnormal_cell_differentiation0.82106915
159MP0002837_dystrophic_cardiac_calcinosis0.82103001
160MP0005390_skeleton_phenotype0.80558896
161MP0000631_abnormal_neuroendocrine_gland0.80020641
162MP0003121_genomic_imprinting0.79559511
163MP0005551_abnormal_eye_electrophysiolog0.79024255
164MP0003656_abnormal_erythrocyte_physiolo0.78284114
165MP0006072_abnormal_retinal_apoptosis0.76971571
166MP0002118_abnormal_lipid_homeostasis0.76589594
167MP0003566_abnormal_cell_adhesion0.75964202
168MP0001958_emphysema0.75136261
169MP0003137_abnormal_impulse_conducting0.74628772
170MP0008874_decreased_physiological_sensi0.73999657
171MP0004085_abnormal_heartbeat0.73094803
172MP0004130_abnormal_muscle_cell0.72384202
173MP0000462_abnormal_digestive_system0.71712353
174MP0005646_abnormal_pituitary_gland0.70176300
175MP0003631_nervous_system_phenotype0.69925345
176MP0002229_neurodegeneration0.69038956
177MP0008877_abnormal_DNA_methylation0.68813327
178MP0000013_abnormal_adipose_tissue0.67148628
179MP0010769_abnormal_survival0.66074592
180MP0006292_abnormal_olfactory_placode0.65597785
181MP0003705_abnormal_hypodermis_morpholog0.65408481
182MP0004215_abnormal_myocardial_fiber0.65273634
183MP0002082_postnatal_lethality0.62615591
184MP0010770_preweaning_lethality0.62615591
185MP0010768_mortality/aging0.62109918
186MP0004145_abnormal_muscle_electrophysio0.61324268
187MP0003045_fibrosis0.60028925
188MP0000537_abnormal_urethra_morphology0.57976234
189MP0001188_hyperpigmentation0.57469241
190MP0004043_abnormal_pH_regulation0.57236569
191MP0002752_abnormal_somatic_nervous0.56731669

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.89203811
2Focal motor seizures (HP:0011153)5.06787501
3Focal seizures (HP:0007359)4.70279440
4Myokymia (HP:0002411)4.41638518
5Recurrent abscess formation (HP:0002722)4.32414031
6Recurrent bacterial skin infections (HP:0005406)4.32235928
7Visual hallucinations (HP:0002367)4.28292765
8Epileptic encephalopathy (HP:0200134)4.20768971
9Myositis (HP:0100614)4.19811502
10Abnormality of macrophages (HP:0004311)4.11688722
11Recurrent gram-negative bacterial infections (HP:0005420)3.97727750
12Abnormality of the lower motor neuron (HP:0002366)3.92435835
13Febrile seizures (HP:0002373)3.71779923
14Orchitis (HP:0100796)3.70923193
15Gingivitis (HP:0000230)3.41418548
16Poor eye contact (HP:0000817)3.29439111
17Systemic lupus erythematosus (HP:0002725)3.28847356
18Abnormal social behavior (HP:0012433)3.26449482
19Impaired social interactions (HP:0000735)3.26449482
20Retrobulbar optic neuritis (HP:0100654)3.26084620
21Optic neuritis (HP:0100653)3.26084620
22Malnutrition (HP:0004395)3.24654557
23Chronic obstructive pulmonary disease (HP:0006510)3.22474686
24Obstructive lung disease (HP:0006536)3.22474686
25Impaired smooth pursuit (HP:0007772)3.20393146
26Atonic seizures (HP:0010819)3.16771887
27Progressive cerebellar ataxia (HP:0002073)3.15381833
28Action tremor (HP:0002345)3.13832047
29Gastrointestinal infarctions (HP:0005244)3.09806972
30Absence seizures (HP:0002121)3.08755126
31Increased IgE level (HP:0003212)3.08146790
32Recurrent fungal infections (HP:0002841)3.04585396
33Ankyloglossia (HP:0010296)3.02495325
34Mediastinal lymphadenopathy (HP:0100721)2.96688591
35Loss of speech (HP:0002371)2.88432885
36Elevated erythrocyte sedimentation rate (HP:0003565)2.87343919
37Meningitis (HP:0001287)2.84885659
38Broad-based gait (HP:0002136)2.84787354
39Hemorrhage of the eye (HP:0011885)2.83485327
40Generalized tonic-clonic seizures (HP:0002069)2.83382705
41Dialeptic seizures (HP:0011146)2.78276419
42Postural instability (HP:0002172)2.78204666
43Dysmetric saccades (HP:0000641)2.77198436
44Recurrent skin infections (HP:0001581)2.76348666
45Spontaneous hematomas (HP:0007420)2.76172274
46Cellulitis (HP:0100658)2.74148550
47Papilledema (HP:0001085)2.74061106
48Dysdiadochokinesis (HP:0002075)2.70100753
49Abnormality of ocular smooth pursuit (HP:0000617)2.69054367
50Amyloidosis (HP:0011034)2.67196743
51Ankle clonus (HP:0011448)2.66826391
52Gastrointestinal inflammation (HP:0004386)2.63363409
53Vasculitis (HP:0002633)2.61965984
54Dysostosis multiplex (HP:0000943)2.61683850
55Ependymoma (HP:0002888)2.61280856
56Colitis (HP:0002583)2.60365440
57Hemoptysis (HP:0002105)2.57698257
58Hemiplegia (HP:0002301)2.56971655
59Chest pain (HP:0100749)2.56829982
60Inflammation of the large intestine (HP:0002037)2.55766389
61Pointed chin (HP:0000307)2.55411604
62Genetic anticipation (HP:0003743)2.51261288
63Gaze-evoked nystagmus (HP:0000640)2.49073389
64Stomatitis (HP:0010280)2.48714865
65Abnormality of the astrocytes (HP:0100707)2.47723447
66Astrocytoma (HP:0009592)2.47723447
67Insomnia (HP:0100785)2.43688046
68Pustule (HP:0200039)2.43539791
69Keratoconjunctivitis sicca (HP:0001097)2.43392480
70Hyperventilation (HP:0002883)2.43192103
71Depression (HP:0000716)2.42707970
72Abnormal delayed hypersensitivity skin test (HP:0002963)2.42579373
73Drooling (HP:0002307)2.41458081
74Excessive salivation (HP:0003781)2.41458081
75Truncal ataxia (HP:0002078)2.40654104
76Urticaria (HP:0001025)2.40329813
77Impaired vibration sensation in the lower limbs (HP:0002166)2.40008119
78Neoplasm of the heart (HP:0100544)2.39067876
79Chronic mucocutaneous candidiasis (HP:0002728)2.35121784
80Recurrent cutaneous fungal infections (HP:0011370)2.35121784
81Urinary glycosaminoglycan excretion (HP:0003541)2.32466738
82Mucopolysacchariduria (HP:0008155)2.32466738
83Status epilepticus (HP:0002133)2.31585958
84Increased cerebral lipofuscin (HP:0011813)2.30865568
85Abnormality of polysaccharide metabolism (HP:0011012)2.29712193
86Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29712193
87Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29712193
88Pulmonary infiltrates (HP:0002113)2.28918004
89Encephalitis (HP:0002383)2.27707087
90Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27483146
91Obsessive-compulsive behavior (HP:0000722)2.27124103
92Abnormality of oral frenula (HP:0000190)2.25594991
93Nasal polyposis (HP:0100582)2.23652411
94Turricephaly (HP:0000262)2.23515516
95Protruding tongue (HP:0010808)2.22446720
96Abnormality of the nasal mucosa (HP:0000433)2.22237656
97Hyperacusis (HP:0010780)2.22069675
98Urinary bladder sphincter dysfunction (HP:0002839)2.21744501
99Epileptiform EEG discharges (HP:0011182)2.21425391
100Abnormality of complement system (HP:0005339)2.21414024
101Prolonged bleeding time (HP:0003010)2.20452714
102Hand muscle atrophy (HP:0009130)2.20444800
103Elfin facies (HP:0004428)2.19950285
104Obstructive sleep apnea (HP:0002870)2.18863680
105Absent speech (HP:0001344)2.16423435
106Flat acetabular roof (HP:0003180)2.14494465
107EEG with generalized epileptiform discharges (HP:0011198)2.13105050
108Keratoconjunctivitis (HP:0001096)2.12444701
109Central scotoma (HP:0000603)2.11264303
110Resting tremor (HP:0002322)2.10236039
111Pulmonary embolism (HP:0002204)2.09434089
112Epistaxis (HP:0000421)2.09193890
113Hemiparesis (HP:0001269)2.08658468
114Anosmia (HP:0000458)2.08474760
115Thin bony cortex (HP:0002753)2.05549720
116Upper limb amyotrophy (HP:0009129)2.05477256
117Distal upper limb amyotrophy (HP:0007149)2.05477256
118Stereotypic behavior (HP:0000733)2.04954251
119Amblyopia (HP:0000646)2.04924636
120Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03900906
121Recurrent viral infections (HP:0004429)2.03671127
122Gingival bleeding (HP:0000225)2.02595586
123Polygenic inheritance (HP:0010982)2.02202458
124Hypertriglyceridemia (HP:0002155)2.01657282
125Abnormality of liposaccharide metabolism (HP:0010968)2.00674887
126Abnormality of glycosphingolipid metabolism (HP:0004343)2.00674887
127Abnormality of glycolipid metabolism (HP:0010969)2.00674887
128Hypsarrhythmia (HP:0002521)2.00272939
129Osteomyelitis (HP:0002754)1.99992272
130Peritonitis (HP:0002586)1.99050320
131Polycythemia (HP:0001901)1.97885029
132Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97371200
133Metaphyseal cupping (HP:0003021)1.96174428
134Asymmetric septal hypertrophy (HP:0001670)1.95578305
135Abnormality of the fingertips (HP:0001211)1.95256924
136Glomerulonephritis (HP:0000099)1.94447051
137Hypochromic anemia (HP:0001931)1.94187230
138Supranuclear gaze palsy (HP:0000605)1.94067582
139Interstitial pulmonary disease (HP:0006530)1.92613948
140Bradykinesia (HP:0002067)1.92275973
141Dysmetria (HP:0001310)1.91730431
142Broad face (HP:0000283)1.91041432
143Slow saccadic eye movements (HP:0000514)1.90029626
144Episodic fever (HP:0001954)1.89408810
145Arterial thrombosis (HP:0004420)1.88720234
146Segmental peripheral demyelination/remyelination (HP:0003481)1.88006320
147Premature loss of primary teeth (HP:0006323)1.87671234
148Deep palmar crease (HP:0006191)1.87075460
149Increased neuronal autofluorescent lipopigment (HP:0002074)1.86269807
150Renal duplication (HP:0000075)1.85496465
151Easy fatigability (HP:0003388)1.85328358
152Granulocytopenia (HP:0001913)1.85308657
153Leukocytosis (HP:0001974)1.84897582
154Complement deficiency (HP:0004431)1.84574804
155Hepatosplenomegaly (HP:0001433)1.84422112
156Urinary urgency (HP:0000012)1.84179202
157Restrictive lung disease (HP:0002091)1.83652516
158Gangrene (HP:0100758)1.82779226
159Acne (HP:0001061)1.81111007
160Torticollis (HP:0000473)1.80378726
161Hypochromic microcytic anemia (HP:0004840)1.79812646
162Chronic diarrhea (HP:0002028)1.79601139
163Glioma (HP:0009733)1.79521038
164Annular pancreas (HP:0001734)1.79296172
165Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79019524
166Intellectual disability, profound (HP:0002187)1.78785194
167Aqueductal stenosis (HP:0002410)1.78517425
168Agitation (HP:0000713)1.76959365
169Hypergammaglobulinemia (HP:0010702)1.76716072
170Abnormality of the pleura (HP:0002103)1.75870214
171Sepsis (HP:0100806)1.75381979
172Purpura (HP:0000979)1.74848797
173Termporal pattern (HP:0011008)1.74731724
174Insidious onset (HP:0003587)1.74731724
175Emphysema (HP:0002097)1.74484080
176Abnormality of the peritoneum (HP:0002585)1.74462325
177Amyotrophic lateral sclerosis (HP:0007354)1.73995005
178Lower limb amyotrophy (HP:0007210)1.73202510
179Scanning speech (HP:0002168)1.72920216
180Abnormal EKG (HP:0003115)1.71833266
181Renovascular hypertension (HP:0100817)1.71760994
182Bundle branch block (HP:0011710)1.71267712
183Heterotopia (HP:0002282)1.71001911
184Autism (HP:0000717)1.66930052
185Anxiety (HP:0000739)1.66186632
186Exotropia (HP:0000577)1.65445543
187Cortical visual impairment (HP:0100704)1.63152089
188Attention deficit hyperactivity disorder (HP:0007018)1.62938787
189Syncope (HP:0001279)1.62410940
190Macroorchidism (HP:0000053)1.61669767
191Clonus (HP:0002169)1.57245127
192Abnormal eating behavior (HP:0100738)1.55752971
193Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.55731992
194Spastic gait (HP:0002064)1.55718248
195Impaired vibratory sensation (HP:0002495)1.55537856
196Progressive sensorineural hearing impairment (HP:0000408)1.54172717
197Short 1st metacarpal (HP:0010034)1.53662650
198Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.53662650
199Hepatoblastoma (HP:0002884)1.53612998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.71749449
2MAP3K94.12981192
3ERN14.03083587
4EPHA43.84748116
5MAP3K43.13276716
6DAPK22.80223289
7MAP4K12.66497046
8PRKD32.51048024
9TYK22.44446039
10MAP2K32.37018082
11STK382.21285696
12MINK12.18864763
13MARK12.11209990
14TNIK2.11070412
15MAP2K42.05206861
16NTRK22.01719894
17EPHB11.98658000
18KSR21.98256097
19MAP2K71.98065104
20BLK1.92966394
21KSR11.91661376
22ZAP701.91236794
23PAK61.89983678
24CSK1.82367906
25IRAK41.81873205
26DAPK11.79810571
27SMG11.76296531
28TNK21.75383671
29CAMK1G1.61872575
30CAMKK11.61310898
31TYRO31.56576802
32MAP3K31.51093326
33SIK21.48221486
34CDK121.44011569
35NTRK11.42779160
36PNCK1.39353012
37RIPK41.38666613
38RIPK11.36901407
39PRPF4B1.36441975
40TESK21.35867571
41TAOK11.35841850
42CAMK1D1.31879146
43FGFR41.31605693
44MAP3K141.28657969
45JAK31.27859202
46IRAK31.24868877
47FGR1.24787950
48JAK11.24364654
49MAP3K111.23497852
50NEK11.23490338
51MAP3K21.21925884
52LATS21.20880148
53TBK11.19515690
54RET1.18791576
55TRIB31.16805136
56PKN21.13335723
57BTK1.11310342
58DYRK1B1.08843674
59HCK1.07471677
60ALK1.06200024
61IKBKE1.04871625
62ICK1.02955203
63CDK51.02275488
64TAOK20.98860986
65JAK20.97900789
66MAP3K70.95157993
67MST1R0.94924062
68SYK0.90902042
69BRD40.88591465
70TAOK30.88124220
71STK110.86267165
72MAP3K120.85562242
73PRKCG0.85296821
74CSF1R0.84470941
75PDGFRA0.83493308
76EPHA30.82030811
77LRRK20.81350616
78CAMK10.79889150
79LMTK20.79656685
80PDK40.78247560
81PDK30.78247560
82MARK20.75217647
83MAPK130.75215521
84LCK0.75045358
85CCNB10.73661688
86LYN0.73530318
87MATK0.73043082
88PTK20.72733194
89CDC42BPA0.71191381
90MAPK120.70541146
91TESK10.70356941
92KIT0.69922368
93EPHA20.69722760
94FES0.69637532
95YES10.69296279
96MAPK70.69284791
97MAP3K130.68880448
98HIPK20.68113461
99UHMK10.67275678
100NEK20.66537248
101AKT30.65284153
102SGK10.63142258
103GRK60.62527078
104CDK180.61735579
105GRK50.61285563
106SIK10.61032590
107SGK30.60898828
108FGFR30.60707596
109MAP2K20.59669608
110FGFR20.59360570
111CDK150.59182803
112DYRK1A0.58928681
113CDK60.58908848
114FER0.58769049
115RPS6KC10.58292250
116RPS6KL10.58292250
117CAMK40.57980798
118FGFR10.57017164
119IRAK10.56280322
120TXK0.56266245
121MARK30.55926023
122IRAK20.55908734
123MAP2K60.55285694
124FYN0.54072193
125PLK20.53547695
126SCYL20.53420899
127CAMKK20.53100665
128PDK10.52887041
129PTK2B0.52885254
130PRKCZ0.52769540
131CHUK0.52686644
132CAMK2A0.52285739
133ITK0.51934288
134RPS6KA20.51259247
135IKBKB0.51085616
136PRKG20.50645442
137CDK140.50441011
138PRKCH0.49974985
139MAPK150.49699545
140PRKAA20.49222029
141EEF2K0.49114665
142PTK60.49085478
143MAP3K10.48761129
144CDK11A0.48279468
145MAPK110.47684272
146MAPK100.47646935
147PRKD20.47213261
148PDPK10.46367595
149ERBB20.45990435
150PDGFRB0.45914042
151RPS6KA30.44568765
152DDR20.44469434
153ERBB30.44118628
154STK100.43750684
155PRKAA10.43390785
156MAP3K100.42843820
157SGK20.42342739
158TTN0.42129508
159PAK30.42061452
160SIK30.41986616
161MAP3K60.41917473
162PHKG20.40515849
163PHKG10.40515849
164CASK0.39799432
165CSNK1E0.39362984
166MTOR0.39272360
167CAMK2B0.36673884

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.99872871
2Synaptic vesicle cycle_Homo sapiens_hsa047212.72763737
3Long-term potentiation_Homo sapiens_hsa047202.60741459
4Other glycan degradation_Homo sapiens_hsa005112.32884827
5Olfactory transduction_Homo sapiens_hsa047402.28920637
6Osteoclast differentiation_Homo sapiens_hsa043802.27829417
7Circadian entrainment_Homo sapiens_hsa047132.27561987
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22955451
9Staphylococcus aureus infection_Homo sapiens_hsa051502.21769421
10Amphetamine addiction_Homo sapiens_hsa050312.21533349
11Leishmaniasis_Homo sapiens_hsa051402.16068455
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.14038402
13GABAergic synapse_Homo sapiens_hsa047272.07476977
14Glutamatergic synapse_Homo sapiens_hsa047242.05465721
15Insulin secretion_Homo sapiens_hsa049112.01125141
16Dopaminergic synapse_Homo sapiens_hsa047281.99937069
17Morphine addiction_Homo sapiens_hsa050321.96727645
18Salivary secretion_Homo sapiens_hsa049701.86234740
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.77957097
20Acute myeloid leukemia_Homo sapiens_hsa052211.73985862
21Type II diabetes mellitus_Homo sapiens_hsa049301.71837456
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.70073781
23B cell receptor signaling pathway_Homo sapiens_hsa046621.68899773
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.65686153
25Gastric acid secretion_Homo sapiens_hsa049711.62641932
26Taste transduction_Homo sapiens_hsa047421.58761454
27Tuberculosis_Homo sapiens_hsa051521.58291032
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.55933526
29Fatty acid biosynthesis_Homo sapiens_hsa000611.54463304
30Cholinergic synapse_Homo sapiens_hsa047251.51291509
31Renin secretion_Homo sapiens_hsa049241.50241940
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.45893997
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45846594
34Oxytocin signaling pathway_Homo sapiens_hsa049211.42785675
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41859320
36Graft-versus-host disease_Homo sapiens_hsa053321.38563665
37GnRH signaling pathway_Homo sapiens_hsa049121.38395076
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.34174158
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.33490444
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.33318066
41Allograft rejection_Homo sapiens_hsa053301.33119583
42Long-term depression_Homo sapiens_hsa047301.32699663
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28232082
44Calcium signaling pathway_Homo sapiens_hsa040201.26861307
45Estrogen signaling pathway_Homo sapiens_hsa049151.25435318
46mTOR signaling pathway_Homo sapiens_hsa041501.25431156
47Malaria_Homo sapiens_hsa051441.25404766
48Glioma_Homo sapiens_hsa052141.24119643
49T cell receptor signaling pathway_Homo sapiens_hsa046601.23851733
50Toxoplasmosis_Homo sapiens_hsa051451.23315369
51ErbB signaling pathway_Homo sapiens_hsa040121.21538016
52Influenza A_Homo sapiens_hsa051641.20829922
53Carbohydrate digestion and absorption_Homo sapiens_hsa049731.19806861
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.19681645
55Renin-angiotensin system_Homo sapiens_hsa046141.19200337
56Notch signaling pathway_Homo sapiens_hsa043301.18314833
57Hepatitis C_Homo sapiens_hsa051601.18176128
58TNF signaling pathway_Homo sapiens_hsa046681.17613361
59Cocaine addiction_Homo sapiens_hsa050301.17266626
60Pertussis_Homo sapiens_hsa051331.16839287
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.15053205
62Gap junction_Homo sapiens_hsa045401.14997082
63Autoimmune thyroid disease_Homo sapiens_hsa053201.14569049
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14145028
65cAMP signaling pathway_Homo sapiens_hsa040241.12342784
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.11899590
67NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11200869
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10897922
69Chemokine signaling pathway_Homo sapiens_hsa040621.09259077
70Chronic myeloid leukemia_Homo sapiens_hsa052201.08839956
71Glucagon signaling pathway_Homo sapiens_hsa049221.08516324
72NF-kappa B signaling pathway_Homo sapiens_hsa040641.07324623
73Oocyte meiosis_Homo sapiens_hsa041141.06317564
74Serotonergic synapse_Homo sapiens_hsa047261.05940635
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03107134
76Melanogenesis_Homo sapiens_hsa049161.02488701
77cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02344467
78Nitrogen metabolism_Homo sapiens_hsa009101.01590293
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00725060
80VEGF signaling pathway_Homo sapiens_hsa043700.99955575
81Hematopoietic cell lineage_Homo sapiens_hsa046400.99229062
82Lysosome_Homo sapiens_hsa041420.98871654
83Amoebiasis_Homo sapiens_hsa051460.95445007
84Phagosome_Homo sapiens_hsa041450.94589853
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.94184132
86Measles_Homo sapiens_hsa051620.93335508
87African trypanosomiasis_Homo sapiens_hsa051430.92870722
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.92170931
89Dorso-ventral axis formation_Homo sapiens_hsa043200.92141798
90Hepatitis B_Homo sapiens_hsa051610.92047305
91Viral myocarditis_Homo sapiens_hsa054160.91630343
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.90716682
93Primary immunodeficiency_Homo sapiens_hsa053400.90696824
94Axon guidance_Homo sapiens_hsa043600.88661067
95Galactose metabolism_Homo sapiens_hsa000520.87986811
96Thyroid hormone synthesis_Homo sapiens_hsa049180.87180985
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.86762402
98Pancreatic cancer_Homo sapiens_hsa052120.85776062
99Insulin signaling pathway_Homo sapiens_hsa049100.85519839
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.84393659
101Intestinal immune network for IgA production_Homo sapiens_hsa046720.83909382
102Choline metabolism in cancer_Homo sapiens_hsa052310.83686091
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83614396
104Salmonella infection_Homo sapiens_hsa051320.83093435
105Antigen processing and presentation_Homo sapiens_hsa046120.82093047
106Herpes simplex infection_Homo sapiens_hsa051680.81673768
107Bile secretion_Homo sapiens_hsa049760.79754430
108Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79405000
109Type I diabetes mellitus_Homo sapiens_hsa049400.79242509
110Histidine metabolism_Homo sapiens_hsa003400.79053081
111Pancreatic secretion_Homo sapiens_hsa049720.78793690
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78312145
113Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78134084
114Asthma_Homo sapiens_hsa053100.77786790
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76880718
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75973183
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.74974622
118Endometrial cancer_Homo sapiens_hsa052130.74567947
119Caffeine metabolism_Homo sapiens_hsa002320.74457801
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.73855610
121Platelet activation_Homo sapiens_hsa046110.72273684
122Renal cell carcinoma_Homo sapiens_hsa052110.71375175
123Complement and coagulation cascades_Homo sapiens_hsa046100.70857545
124Apoptosis_Homo sapiens_hsa042100.70408772
125Legionellosis_Homo sapiens_hsa051340.69896287
126PPAR signaling pathway_Homo sapiens_hsa033200.67832908
127Sphingolipid signaling pathway_Homo sapiens_hsa040710.67251872
128AMPK signaling pathway_Homo sapiens_hsa041520.66345955
129MAPK signaling pathway_Homo sapiens_hsa040100.65971932
130Collecting duct acid secretion_Homo sapiens_hsa049660.65473116
131Circadian rhythm_Homo sapiens_hsa047100.64487864
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64340791
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.63754518
134Prolactin signaling pathway_Homo sapiens_hsa049170.63020788
135Rap1 signaling pathway_Homo sapiens_hsa040150.62730949
136Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61803849
137Starch and sucrose metabolism_Homo sapiens_hsa005000.60812077
138Non-small cell lung cancer_Homo sapiens_hsa052230.60524406
139Wnt signaling pathway_Homo sapiens_hsa043100.59862783
140Prion diseases_Homo sapiens_hsa050200.59432423
141FoxO signaling pathway_Homo sapiens_hsa040680.59170366
142Inositol phosphate metabolism_Homo sapiens_hsa005620.58951309
143Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58270797
144Colorectal cancer_Homo sapiens_hsa052100.58014192
145Phototransduction_Homo sapiens_hsa047440.56802294
146Vibrio cholerae infection_Homo sapiens_hsa051100.55490526
147Fructose and mannose metabolism_Homo sapiens_hsa000510.55205204
148Shigellosis_Homo sapiens_hsa051310.54940037
149Vitamin digestion and absorption_Homo sapiens_hsa049770.54389973
150Hippo signaling pathway_Homo sapiens_hsa043900.54370110
151Lysine degradation_Homo sapiens_hsa003100.53471419
152Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52987096
153Insulin resistance_Homo sapiens_hsa049310.52737841
154Arachidonic acid metabolism_Homo sapiens_hsa005900.52707236
155Glycerolipid metabolism_Homo sapiens_hsa005610.51959994
156Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51624884
157Dilated cardiomyopathy_Homo sapiens_hsa054140.51388369
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50954306
159Rheumatoid arthritis_Homo sapiens_hsa053230.50334158
160Tight junction_Homo sapiens_hsa045300.50315265
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48508441
162Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48490233
163Bladder cancer_Homo sapiens_hsa052190.47368596
164Thyroid cancer_Homo sapiens_hsa052160.45877056
165Ras signaling pathway_Homo sapiens_hsa040140.42038054
166Glycerophospholipid metabolism_Homo sapiens_hsa005640.41606707
167Fat digestion and absorption_Homo sapiens_hsa049750.40642612
168Hedgehog signaling pathway_Homo sapiens_hsa043400.40613349
169Endocytosis_Homo sapiens_hsa041440.39393622

Most similar genes based on co-expression Upload to Enrichr

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