FAM160B1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)6.03547261
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.03547261
3negative regulation of fibrinolysis (GO:0051918)5.89119324
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88739001
5L-phenylalanine metabolic process (GO:0006558)5.88739001
6aromatic amino acid family catabolic process (GO:0009074)5.55668663
7triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.45899410
8regulation of fibrinolysis (GO:0051917)5.29021562
9indole-containing compound catabolic process (GO:0042436)5.16361449
10indolalkylamine catabolic process (GO:0046218)5.16361449
11tryptophan catabolic process (GO:0006569)5.16361449
12kynurenine metabolic process (GO:0070189)5.16076794
13alpha-linolenic acid metabolic process (GO:0036109)5.09595628
14peptidyl-glutamic acid carboxylation (GO:0017187)5.02873813
15protein carboxylation (GO:0018214)5.02873813
16tryptophan metabolic process (GO:0006568)4.99379185
17urea cycle (GO:0000050)4.96269350
18urea metabolic process (GO:0019627)4.96269350
19complement activation, alternative pathway (GO:0006957)4.86747631
20sulfur amino acid catabolic process (GO:0000098)4.80066545
21high-density lipoprotein particle remodeling (GO:0034375)4.79126092
22bile acid biosynthetic process (GO:0006699)4.66193561
23regulation of protein activation cascade (GO:2000257)4.62415366
24glyoxylate metabolic process (GO:0046487)4.42685905
25nitrogen cycle metabolic process (GO:0071941)4.40185954
26reverse cholesterol transport (GO:0043691)4.38206868
27phospholipid efflux (GO:0033700)4.35596894
28regulation of complement activation (GO:0030449)4.33692345
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25966331
30bile acid metabolic process (GO:0008206)4.17323976
31negative regulation of sterol transport (GO:0032372)4.10500246
32negative regulation of cholesterol transport (GO:0032375)4.10500246
33intestinal cholesterol absorption (GO:0030299)4.06597503
34cysteine metabolic process (GO:0006534)4.05324546
35plasma lipoprotein particle remodeling (GO:0034369)4.02340113
36protein-lipid complex remodeling (GO:0034368)4.02340113
37macromolecular complex remodeling (GO:0034367)4.02340113
38acylglycerol homeostasis (GO:0055090)4.01020572
39triglyceride homeostasis (GO:0070328)4.01020572
40regulation of cholesterol homeostasis (GO:2000188)3.97165499
41regulation of cholesterol esterification (GO:0010872)3.94243176
42homocysteine metabolic process (GO:0050667)3.93691561
43regulation of triglyceride catabolic process (GO:0010896)3.90706873
44cholesterol efflux (GO:0033344)3.88534057
45tyrosine metabolic process (GO:0006570)3.87638210
46aromatic amino acid family metabolic process (GO:0009072)3.86898637
47plasma lipoprotein particle assembly (GO:0034377)3.85533004
48coenzyme catabolic process (GO:0009109)3.78172538
49positive regulation of gamma-delta T cell activation (GO:0046645)3.76372841
50serine family amino acid catabolic process (GO:0009071)3.73901235
51dicarboxylic acid biosynthetic process (GO:0043650)3.70300708
52plasma lipoprotein particle clearance (GO:0034381)3.68268943
53alpha-amino acid catabolic process (GO:1901606)3.59572698
54indolalkylamine metabolic process (GO:0006586)3.58534246
55cellular modified amino acid catabolic process (GO:0042219)3.58032893
56valine metabolic process (GO:0006573)3.54179792
57phospholipid homeostasis (GO:0055091)3.53486853
58protein-lipid complex assembly (GO:0065005)3.47179261
59imidazole-containing compound metabolic process (GO:0052803)3.45999202
60amino-acid betaine metabolic process (GO:0006577)3.42300405
61very-low-density lipoprotein particle assembly (GO:0034379)3.41251184
62bile acid and bile salt transport (GO:0015721)3.38546685
63lipoprotein metabolic process (GO:0042157)3.37701031
64benzene-containing compound metabolic process (GO:0042537)3.33575524
65cholesterol homeostasis (GO:0042632)3.33261675
66fibrinolysis (GO:0042730)3.33139582
67plasma lipoprotein particle organization (GO:0071827)3.32638792
68positive regulation of lipid catabolic process (GO:0050996)3.31580792
69sterol homeostasis (GO:0055092)3.31417517
70amine catabolic process (GO:0009310)3.30681583
71cellular biogenic amine catabolic process (GO:0042402)3.30681583
72glutamine family amino acid biosynthetic process (GO:0009084)3.29772196
73cytolysis (GO:0019835)3.29568925
74lysine metabolic process (GO:0006553)3.28625456
75lysine catabolic process (GO:0006554)3.28625456
76complement activation (GO:0006956)3.27117192
77cellular amino acid catabolic process (GO:0009063)3.26534648
78cellular extravasation (GO:0045123)3.24849185
79low-density lipoprotein particle remodeling (GO:0034374)3.24786177
80proline biosynthetic process (GO:0006561)3.20905232
81ethanol oxidation (GO:0006069)3.20456770
82complement activation, classical pathway (GO:0006958)3.20307660
83glutamate metabolic process (GO:0006536)3.20285345
84detection of molecule of bacterial origin (GO:0032490)3.20128589
85protein activation cascade (GO:0072376)3.19036547
86negative regulation of lipase activity (GO:0060192)3.18350553
87blood coagulation, intrinsic pathway (GO:0007597)3.16652892
88protein-lipid complex subunit organization (GO:0071825)3.13781406
89negative regulation of fatty acid biosynthetic process (GO:0045717)3.12453047
90positive regulation of fatty acid beta-oxidation (GO:0032000)3.11378704
91glycine metabolic process (GO:0006544)3.08529814
92cofactor catabolic process (GO:0051187)3.08178925
93acute-phase response (GO:0006953)3.05896098
94positive regulation of triglyceride lipase activity (GO:0061365)3.04576074
95positive regulation of lipoprotein lipase activity (GO:0051006)3.04576074
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.02944024
97positive regulation of hemostasis (GO:1900048)3.01304654
98positive regulation of blood coagulation (GO:0030194)3.01304654
99embryonic process involved in female pregnancy (GO:0060136)3.00259489
100cellular glucuronidation (GO:0052695)2.99707925
101NAD biosynthetic process (GO:0009435)2.99619372
102regulation of plasminogen activation (GO:0010755)2.97591429
103epoxygenase P450 pathway (GO:0019373)2.96623515
104response to muramyl dipeptide (GO:0032495)2.96174952
105positive regulation of coagulation (GO:0050820)2.92215148
106regulation of B cell receptor signaling pathway (GO:0050855)2.91997432
107arginine metabolic process (GO:0006525)2.89657789
108protein targeting to Golgi (GO:0000042)2.88256746
109negative regulation of erythrocyte differentiation (GO:0045647)2.86402546
110definitive hemopoiesis (GO:0060216)2.83818346
111retrograde transport, vesicle recycling within Golgi (GO:0000301)2.83650599
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.81673723
113response to peptidoglycan (GO:0032494)2.81061712
114modulation by symbiont of host immune response (GO:0052553)2.79481507
115positive regulation by symbiont of host defense response (GO:0052509)2.79481507
116modulation by symbiont of host defense response (GO:0052031)2.79481507
117modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.79481507
118modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.79481507
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.79481507
120pathway-restricted SMAD protein phosphorylation (GO:0060389)2.79303561
121establishment of protein localization to Golgi (GO:0072600)2.78989508
122negative regulation of cell killing (GO:0031342)2.76500717
123negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76500717
124cellular response to ethanol (GO:0071361)2.73834221
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.71658977
126positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.70828612
127regulation of macrophage cytokine production (GO:0010935)2.70720835
128detection of other organism (GO:0098543)2.68706551
129negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.66639239
130negative regulation of T-helper cell differentiation (GO:0045623)2.66639239
131regulation of gamma-delta T cell activation (GO:0046643)2.65904671
132negative regulation of interleukin-12 production (GO:0032695)2.65566817
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63205757
134detection of external biotic stimulus (GO:0098581)2.62744368
135germinal center formation (GO:0002467)2.59176297
136response to interleukin-15 (GO:0070672)2.58874259
137macrophage activation involved in immune response (GO:0002281)2.58767721
138B cell receptor signaling pathway (GO:0050853)2.57819966
139interleukin-6-mediated signaling pathway (GO:0070102)2.57382301
140regulation of gamma-delta T cell differentiation (GO:0045586)2.56475031
141response to laminar fluid shear stress (GO:0034616)2.49195904
142regulation of T-helper 1 cell differentiation (GO:0045625)2.47841500
143antigen processing and presentation of endogenous antigen (GO:0019883)2.46725881
144negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.46055523
145positive regulation of macrophage cytokine production (GO:0060907)2.43924709
146antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.42448050
147regulation of necroptotic process (GO:0060544)2.41559378
148regulation of B cell differentiation (GO:0045577)2.41462662
149platelet-derived growth factor receptor signaling pathway (GO:0048008)2.40001792
150hemoglobin metabolic process (GO:0020027)2.39698467
151phospholipid translocation (GO:0045332)2.39174935
152lipid translocation (GO:0034204)2.39174935
153neutrophil mediated immunity (GO:0002446)2.36880913
154regulation of protein polyubiquitination (GO:1902914)2.34888901
155positive regulation of fibroblast migration (GO:0010763)2.34723067
156production of molecular mediator involved in inflammatory response (GO:0002532)2.34478217
157positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33933919
158positive regulation of B cell differentiation (GO:0045579)2.33778601
159positive regulation of natural killer cell differentiation (GO:0032825)2.33202834
160detection of bacterium (GO:0016045)2.28791423
161regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.27370701
162leukocyte aggregation (GO:0070486)2.26443408
163B cell homeostasis (GO:0001782)2.25931464
164negative regulation of interleukin-17 production (GO:0032700)2.24991884
165neutrophil activation involved in immune response (GO:0002283)2.23945961
166regulation of T-helper 2 cell differentiation (GO:0045628)2.23944357
167regulation of interferon-beta biosynthetic process (GO:0045357)2.23745952
168regulation of transforming growth factor beta2 production (GO:0032909)2.21943592
169positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.20913744
170cellular response to epinephrine stimulus (GO:0071872)2.20799450
171detection of biotic stimulus (GO:0009595)2.19975160
172response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.17372018
173response to host (GO:0075136)2.17372018
174response to host defenses (GO:0052200)2.17372018
175Rap protein signal transduction (GO:0032486)2.17298568
176regulation of interleukin-12 biosynthetic process (GO:0045075)2.16137243
177positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.15624242
178T cell migration (GO:0072678)2.13946440
179regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.13089758
180negative thymic T cell selection (GO:0045060)2.12486661
181hypotonic response (GO:0006971)2.12086878
182lipopolysaccharide-mediated signaling pathway (GO:0031663)2.11816923
183monoubiquitinated protein deubiquitination (GO:0035520)2.10828420
184response to host immune response (GO:0052572)2.08447299
185response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.08447299
186JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.08168800
187CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.07084854
188T-helper cell differentiation (GO:0042093)2.07084854
189interkinetic nuclear migration (GO:0022027)2.05455896
190negative regulation of T cell mediated immunity (GO:0002710)2.04874931
191macrophage activation (GO:0042116)2.03902801
192cellular response to interleukin-15 (GO:0071350)2.03732833
193myeloid leukocyte mediated immunity (GO:0002444)2.03698179
194cellular response to interferon-alpha (GO:0035457)2.03563618
195positive regulation of interferon-alpha production (GO:0032727)2.02965178
196negative T cell selection (GO:0043383)2.02938751
197sequestering of extracellular ligand from receptor (GO:0035581)2.02036417
198microglial cell activation (GO:0001774)2.02023315
199I-kappaB phosphorylation (GO:0007252)2.01697715
200negative regulation of cAMP-mediated signaling (GO:0043951)2.01095403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.07034748
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.12898943
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.49621715
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.88363798
5SMAD_19615063_ChIP-ChIP_OVARY_Human4.52488415
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.30292639
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.80062031
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24416343
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.08321967
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.04631951
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.70939834
12GATA1_22025678_ChIP-Seq_K562_Human2.67583652
13CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.48660140
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33261174
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.21751264
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20823136
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.19806519
18BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.14448060
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.05635386
20SCL_19346495_ChIP-Seq_HPC-7_Human1.98828069
21MYB_21317192_ChIP-Seq_ERMYB_Mouse1.82571400
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.80178819
23VDR_24787735_ChIP-Seq_THP-1_Human1.79107811
24CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.79012373
25MYC_22102868_ChIP-Seq_BL_Human1.76757542
26ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72407962
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72405508
28BRD4_25478319_ChIP-Seq_HGPS_Human1.72061908
29TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.71933378
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.71075074
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69651668
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66597480
33CLOCK_20551151_ChIP-Seq_293T_Human1.64927286
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62096746
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.61208912
36NRF2_20460467_ChIP-Seq_MEFs_Mouse1.61208912
37* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61159897
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60981285
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.59068291
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.58506493
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53867587
42* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.53545479
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.52114094
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.52078668
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51126703
46VDR_21846776_ChIP-Seq_THP-1_Human1.49518362
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.42964706
48* CJUN_26792858_Chip-Seq_BT549_Human1.42065723
49PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.41348092
50FOXA2_19822575_ChIP-Seq_HepG2_Human1.40986156
51THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.39423925
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38862779
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.38435845
54GBX2_23144817_ChIP-Seq_PC3_Human1.35761466
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34880295
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34090619
57* RUNX_20019798_ChIP-Seq_JUKART_Human1.33208631
58IRF8_27001747_Chip-Seq_BMDM_Mouse1.32424547
59TP53_16413492_ChIP-PET_HCT116_Human1.31791114
60MAF_26560356_Chip-Seq_TH1_Human1.28872529
61NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.28166667
62LXR_22292898_ChIP-Seq_THP-1_Human1.27257766
63MYB_26560356_Chip-Seq_TH1_Human1.25832165
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25326685
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.24107758
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22574372
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.22467203
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22454159
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.22365147
70* KDM2B_26808549_Chip-Seq_DND41_Human1.21718609
71HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21173878
72AHR_22903824_ChIP-Seq_MCF-7_Human1.20216017
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17902457
74UTX_26944678_Chip-Seq_JUKART_Human1.17593462
75SOX2_27498859_Chip-Seq_STOMACH_Mouse1.17413515
76* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.15988934
77* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15225660
78VDR_24763502_ChIP-Seq_THP-1_Human1.14025621
79ARNT_22903824_ChIP-Seq_MCF-7_Human1.13659326
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13017286
81GATA1_19941826_ChIP-Seq_K562_Human1.12443997
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12001922
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.11967973
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.11790969
85HNF4A_19822575_ChIP-Seq_HepG2_Human1.11522808
86IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11085318
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.10854739
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10840076
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10133632
90TP63_23658742_ChIP-Seq_EP156T_Human1.09961484
91Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09881003
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08162130
93RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.08065387
94TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07749861
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.07638997
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06650949
97STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06114220
98SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.05390085
99SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.05390085
100* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05342422
101* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04744793
102GATA2_19941826_ChIP-Seq_K562_Human1.01994735
103PU_27001747_Chip-Seq_BMDM_Mouse1.01880856
104PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01571079
105TP53_18474530_ChIP-ChIP_U2OS_Human1.01281174
106RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00918224
107SALL1_21062744_ChIP-ChIP_HESCs_Human1.00803800
108PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.00646124
109NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00325952
110NCOR1_26117541_ChIP-Seq_K562_Human1.00275945
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98982247
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98811889
113SMAD4_21799915_ChIP-Seq_A2780_Human0.97905820
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.97328044
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96960994
116* MYB_26560356_Chip-Seq_TH2_Human0.96831584
117FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96473986
118RUNX1_22412390_ChIP-Seq_EML_Mouse0.96434450
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.95552968
120RACK7_27058665_Chip-Seq_MCF-7_Human0.95308032
121CDX2_20551321_ChIP-Seq_CACO-2_Human0.94386364
122IRF8_21731497_ChIP-ChIP_J774_Mouse0.93800064
123TCF4_18268006_ChIP-ChIP_LS174T_Human0.93334497
124FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93053286
125TAF15_26573619_Chip-Seq_HEK293_Human0.93036015
126* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.93014515
127STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92843489
128SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92735650
129* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91768991
130OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91652151
131GATA1_19941827_ChIP-Seq_MEL_Mouse0.91008650
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90955076
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90804179
134* GATA3_27048872_Chip-Seq_THYMUS_Human0.90720770
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.88811939
136FLI1_21867929_ChIP-Seq_TH2_Mouse0.88244985
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.87324604
138SPI1_23127762_ChIP-Seq_K562_Human0.87240617
139SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86919300
140SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86741585
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.86461639
142FLI1_27457419_Chip-Seq_LIVER_Mouse0.86241326
143JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85692197
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85681408
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85627234
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.85370704
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85072600
148* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82662936
149* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.81767492
150RARG_19884340_ChIP-ChIP_MEFs_Mouse0.81644787
151GATA6_25053715_ChIP-Seq_YYC3_Human0.80727395
152ZNF263_19887448_ChIP-Seq_K562_Human0.76432806
153SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.76010768
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.75792356
155* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75291945
156GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.73327261
157SPI1_23547873_ChIP-Seq_NB4_Human0.73232196
158* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72096281
159LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71719366
160SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71067481
161PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69827879

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.16355553
2MP0005360_urolithiasis5.74053874
3MP0005085_abnormal_gallbladder_physiolo5.33801378
4MP0005365_abnormal_bile_salt5.31122218
5MP0008438_abnormal_cutaneous_collagen3.64643096
6MP0003252_abnormal_bile_duct3.49159682
7MP0008875_abnormal_xenobiotic_pharmacok3.33898345
8MP0003828_pulmonary_edema3.29928264
9MP0000569_abnormal_digit_pigmentation3.13030214
10MP0010329_abnormal_lipoprotein_level2.85666917
11MP0009840_abnormal_foam_cell2.51313535
12MP0001666_abnormal_nutrient_absorption2.42890812
13MP0003091_abnormal_cell_migration2.38116154
14MP0003806_abnormal_nucleotide_metabolis2.23810828
15MP0005083_abnormal_biliary_tract2.11150310
16MP0003191_abnormal_cellular_cholesterol2.10606552
17MP0005275_abnormal_skin_tensile2.04286605
18MP0000609_abnormal_liver_physiology2.03341925
19MP0002138_abnormal_hepatobiliary_system1.93016600
20MP0003868_abnormal_feces_composition1.92235510
21MP0001958_emphysema1.90734006
22MP0003705_abnormal_hypodermis_morpholog1.86746571
23MP0003763_abnormal_thymus_physiology1.77286014
24MP0005332_abnormal_amino_acid1.71869064
25MP0002118_abnormal_lipid_homeostasis1.70407485
26MP0009278_abnormal_bone_marrow1.68721750
27MP0003045_fibrosis1.68364848
28MP0000465_gastrointestinal_hemorrhage1.66825024
29MP0005000_abnormal_immune_tolerance1.61674235
30MP0010368_abnormal_lymphatic_system1.60603095
31MP0001851_eye_inflammation1.57303834
32MP0004883_abnormal_blood_vessel1.56805859
33MP0003221_abnormal_cardiomyocyte_apopto1.55490648
34MP0001545_abnormal_hematopoietic_system1.54600652
35MP0005397_hematopoietic_system_phenotyp1.54600652
36MP0003195_calcinosis1.50399441
37MP0005319_abnormal_enzyme/_coenzyme1.50375322
38MP0003300_gastrointestinal_ulcer1.46431494
39MP0003436_decreased_susceptibility_to1.44677663
40MP0001542_abnormal_bone_strength1.43793169
41MP0002998_abnormal_bone_remodeling1.41693897
42MP0002166_altered_tumor_susceptibility1.39915139
43MP0005164_abnormal_response_to1.39423093
44MP0000598_abnormal_liver_morphology1.35635700
45MP0003950_abnormal_plasma_membrane1.34713336
46MP0000685_abnormal_immune_system1.34622101
47MP0002723_abnormal_immune_serum1.32291030
48MP0005464_abnormal_platelet_physiology1.32190738
49MP0002148_abnormal_hypersensitivity_rea1.30767316
50MP0006054_spinal_hemorrhage1.30557538
51MP0002452_abnormal_antigen_presenting1.28673491
52MP0009697_abnormal_copulation1.27975354
53MP0002420_abnormal_adaptive_immunity1.26585978
54MP0001819_abnormal_immune_cell1.24143848
55MP0002332_abnormal_exercise_endurance1.23792623
56MP0004019_abnormal_vitamin_homeostasis1.22406023
57MP0003656_abnormal_erythrocyte_physiolo1.20875085
58MP0001764_abnormal_homeostasis1.20050894
59MP0002396_abnormal_hematopoietic_system1.19227098
60MP0004510_myositis1.16623475
61MP0005584_abnormal_enzyme/coenzyme_acti1.16557515
62MP0005388_respiratory_system_phenotype1.15519420
63MP0002133_abnormal_respiratory_system1.15519420
64MP0003448_altered_tumor_morphology1.13803498
65MP0010352_gastrointestinal_tract_polyps1.09358025
66MP0008004_abnormal_stomach_pH1.09249707
67MP0004272_abnormal_basement_membrane1.09007852
68MP0003183_abnormal_peptide_metabolism1.07628686
69MP0004484_altered_response_of1.07292477
70MP0004264_abnormal_extraembryonic_tissu1.05090245
71MP0002877_abnormal_melanocyte_morpholog1.04207213
72MP0005503_abnormal_tendon_morphology1.04084333
73MP0002168_other_aberrant_phenotype1.03840679
74MP0002398_abnormal_bone_marrow1.03518196
75MP0002928_abnormal_bile_duct1.02007324
76MP0009763_increased_sensitivity_to1.00662930
77MP0008469_abnormal_protein_level0.99554181
78MP0008260_abnormal_autophagy0.98041741
79MP0000013_abnormal_adipose_tissue0.97391951
80MP0009643_abnormal_urine_homeostasis0.96013596
81MP0005623_abnormal_meninges_morphology0.94929396
82MP0003303_peritoneal_inflammation0.94841813
83MP0000716_abnormal_immune_system0.94371350
84MP0005390_skeleton_phenotype0.93764992
85MP0010386_abnormal_urinary_bladder0.93167432
86MP0009384_cardiac_valve_regurgitation0.92932690
87MP0001835_abnormal_antigen_presentation0.92677552
88MP0005220_abnormal_exocrine_pancreas0.92298215
89MP0002933_joint_inflammation0.91853752
90MP0003172_abnormal_lysosome_physiology0.91211453
91MP0001348_abnormal_lacrimal_gland0.90629193
92MP0004130_abnormal_muscle_cell0.89782768
93MP0005058_abnormal_lysosome_morphology0.89275815
94MP0002254_reproductive_system_inflammat0.88975683
95MP0002006_tumorigenesis0.85373984
96MP0000015_abnormal_ear_pigmentation0.85259149
97MP0004084_abnormal_cardiac_muscle0.85037752
98MP0005671_abnormal_response_to0.84389386
99MP0001853_heart_inflammation0.83889466
100MP0002722_abnormal_immune_system0.83656820
101MP0005334_abnormal_fat_pad0.83470498
102MP0006138_congestive_heart_failure0.82721179
103MP0009764_decreased_sensitivity_to0.82412355
104MP0005408_hypopigmentation0.82333966
105MP0005023_abnormal_wound_healing0.82288258
106MP0002128_abnormal_blood_circulation0.81451656
107MP0002419_abnormal_innate_immunity0.81347979
108MP0000639_abnormal_adrenal_gland0.80964023
109MP0001879_abnormal_lymphatic_vessel0.78616013
110MP0002127_abnormal_cardiovascular_syste0.78417654
111MP0001915_intracranial_hemorrhage0.78080527
112MP0003795_abnormal_bone_structure0.77053162
113MP0005647_abnormal_sex_gland0.76813809
114MP0000858_altered_metastatic_potential0.75801038
115MP0001845_abnormal_inflammatory_respons0.75181568
116MP0005621_abnormal_cell_physiology0.75158751
117MP0009642_abnormal_blood_homeostasis0.75139261
118MP0005025_abnormal_response_to0.73886667
119MP0003724_increased_susceptibility_to0.73684063
120MP0009765_abnormal_xenobiotic_induced0.72926134
121MP0002078_abnormal_glucose_homeostasis0.72536729
122MP0003279_aneurysm0.71632357
123MP0005167_abnormal_blood-brain_barrier0.71571948
124MP0002971_abnormal_brown_adipose0.70234149
125MP0005387_immune_system_phenotype0.70104596
126MP0001790_abnormal_immune_system0.70104596
127MP0004808_abnormal_hematopoietic_stem0.69677334
128MP0005670_abnormal_white_adipose0.69520958
129MP0000371_diluted_coat_color0.69256151
130MP0010155_abnormal_intestine_physiology0.69207154
131MP0000767_abnormal_smooth_muscle0.68055454
132MP0005084_abnormal_gallbladder_morpholo0.67771661
133MP0008057_abnormal_DNA_replication0.67685418
134MP0002009_preneoplasia0.66898918
135MP0004947_skin_inflammation0.65653867
136MP0003075_altered_response_to0.65408723
137MP0003943_abnormal_hepatobiliary_system0.64890112
138MP0002060_abnormal_skin_morphology0.64765921
139MP0005376_homeostasis/metabolism_phenot0.64646116
140MP0003638_abnormal_response/metabolism_0.64457838
141MP0001800_abnormal_humoral_immune0.64087917
142MP0009115_abnormal_fat_cell0.63806660
143MP0000249_abnormal_blood_vessel0.63482494
144MP0005174_abnormal_tail_pigmentation0.61875667
145MP0002405_respiratory_system_inflammati0.61481531
146MP0005076_abnormal_cell_differentiation0.61376805
147MP0006082_CNS_inflammation0.61262096
148MP0009785_altered_susceptibility_to0.61104277
149MP0003566_abnormal_cell_adhesion0.59258979
150MP0000689_abnormal_spleen_morphology0.58777573
151MP0005075_abnormal_melanosome_morpholog0.57411894
152MP0004782_abnormal_surfactant_physiolog0.57410537
153MP0001533_abnormal_skeleton_physiology0.55896177

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.17217870
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.61107911
3Intrahepatic cholestasis (HP:0001406)5.51496126
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.05380191
5Prolonged partial thromboplastin time (HP:0003645)5.04524122
6Xanthomatosis (HP:0000991)4.90237172
7Complement deficiency (HP:0004431)4.76934301
8Hypobetalipoproteinemia (HP:0003563)4.75462745
9Abnormality of the common coagulation pathway (HP:0010990)4.19215490
10Epidermoid cyst (HP:0200040)4.07967616
11Joint hemorrhage (HP:0005261)4.04528381
12Spondylolisthesis (HP:0003302)3.91970085
13Hyperlipoproteinemia (HP:0010980)3.73903949
14Hypoglycemic coma (HP:0001325)3.71019045
15Abnormality of the intrinsic pathway (HP:0010989)3.69922029
16Abnormality of complement system (HP:0005339)3.69627712
17Hypercholesterolemia (HP:0003124)3.43777472
18Aortic aneurysm (HP:0004942)3.42505500
19Protrusio acetabuli (HP:0003179)3.41694466
20Hypolipoproteinemia (HP:0010981)3.41607227
21Hypochromic microcytic anemia (HP:0004840)3.36213865
22Abnormality of sulfur amino acid metabolism (HP:0004339)3.34651494
23Ketosis (HP:0001946)3.31533574
24Myocardial infarction (HP:0001658)3.27097307
25Vascular tortuosity (HP:0004948)3.26609396
26Abnormality of methionine metabolism (HP:0010901)3.26111626
27Arterial tortuosity (HP:0005116)3.23003990
28Aortic dissection (HP:0002647)3.20526544
29Fat malabsorption (HP:0002630)3.14900918
30Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.12863929
31Systemic lupus erythematosus (HP:0002725)3.11621011
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.06727820
33Spontaneous hematomas (HP:0007420)3.06099581
34Abnormality of pyrimidine metabolism (HP:0004353)3.00581092
35Eczematoid dermatitis (HP:0000976)2.98288358
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.96743852
37Hyperammonemia (HP:0001987)2.95558858
38Skin nodule (HP:0200036)2.89746323
39Hypoalphalipoproteinemia (HP:0003233)2.89470830
40Spinal cord lesions (HP:0100561)2.71310357
41Syringomyelia (HP:0003396)2.71310357
42Hypoglycemic seizures (HP:0002173)2.70697817
43Thoracolumbar scoliosis (HP:0002944)2.67455681
44Pancreatic islet-cell hyperplasia (HP:0004510)2.67273108
45Polycythemia (HP:0001901)2.66757464
46Hepatocellular carcinoma (HP:0001402)2.66648744
47Papillary thyroid carcinoma (HP:0002895)2.64256779
48Absent frontal sinuses (HP:0002688)2.64023399
49Dilatation of the ascending aorta (HP:0005111)2.63238704
50Premature rupture of membranes (HP:0001788)2.63035435
51Overgrowth (HP:0001548)2.62955360
52Recurrent gram-negative bacterial infections (HP:0005420)2.61436235
53Gingival bleeding (HP:0000225)2.60295103
54Glomerulonephritis (HP:0000099)2.59542461
55Esophageal varix (HP:0002040)2.57763516
56Ketoacidosis (HP:0001993)2.54031996
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.50149388
58Hyperbilirubinemia (HP:0002904)2.49991051
59Recurrent abscess formation (HP:0002722)2.49151029
60Abnormal platelet volume (HP:0011876)2.47203607
61Conjugated hyperbilirubinemia (HP:0002908)2.46307800
62Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.45351629
63Increased mean platelet volume (HP:0011877)2.45061290
64T lymphocytopenia (HP:0005403)2.43595510
65Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.43558643
66Mitral stenosis (HP:0001718)2.42491945
67Abnormality of T cell number (HP:0011839)2.39830330
68Abnormality of endocrine pancreas physiology (HP:0012093)2.39655718
69Abnormality of the pancreatic islet cells (HP:0006476)2.39655718
70Hematochezia (HP:0002573)2.38494598
71Hyperglycinemia (HP:0002154)2.36472465
72Orchitis (HP:0100796)2.35057108
73Myositis (HP:0100614)2.32541845
74Menorrhagia (HP:0000132)2.31416199
75Recurrent cutaneous fungal infections (HP:0011370)2.31293968
76Chronic mucocutaneous candidiasis (HP:0002728)2.31293968
77Mitral valve prolapse (HP:0001634)2.31280338
78Hyperinsulinemic hypoglycemia (HP:0000825)2.28977067
79Acanthocytosis (HP:0001927)2.28648502
80Testicular neoplasm (HP:0010788)2.28303275
81Delayed CNS myelination (HP:0002188)2.27981921
82Thrombophlebitis (HP:0004418)2.27233821
83Spontaneous abortion (HP:0005268)2.25952992
84Abnormality of nucleobase metabolism (HP:0010932)2.25504659
85Osteolytic defects of the hand bones (HP:0009699)2.24345583
86Osteolytic defects of the phalanges of the hand (HP:0009771)2.24345583
87Subacute progressive viral hepatitis (HP:0006572)2.24299706
88Nephritis (HP:0000123)2.23546239
89Gingivitis (HP:0000230)2.22994285
90Epistaxis (HP:0000421)2.22503297
91Steatorrhea (HP:0002570)2.18992096
92Wormian bones (HP:0002645)2.18468187
93Pulmonary embolism (HP:0002204)2.16449448
94Retrobulbar optic neuritis (HP:0100654)2.15709798
95Optic neuritis (HP:0100653)2.15709798
96Abnormality of fatty-acid metabolism (HP:0004359)2.14469552
97Abnormality of the peritoneum (HP:0002585)2.13247509
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.12855056
99Abnormality of serine family amino acid metabolism (HP:0010894)2.10513289
100Abnormality of glycine metabolism (HP:0010895)2.10513289
101Recurrent fungal infections (HP:0002841)2.06078108
102Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.05336373
103Hyperglycinuria (HP:0003108)2.05237704
104Hypoplasia of the iris (HP:0007676)2.03233523
105Facial diplegia (HP:0001349)2.03156479
106Spastic diplegia (HP:0001264)2.02419361
107Scanning speech (HP:0002168)2.00614798
108Ulnar bowing (HP:0003031)2.00422413
109Metaphyseal dysplasia (HP:0100255)1.99835490
110Hemorrhage of the eye (HP:0011885)1.99184226
111Pulmonary infiltrates (HP:0002113)1.96978428
112Gastrointestinal infarctions (HP:0005244)1.96700596
113Asymmetric septal hypertrophy (HP:0001670)1.94460178
114Recurrent skin infections (HP:0001581)1.94091971
115Turricephaly (HP:0000262)1.93610262
116Soft skin (HP:0000977)1.92325881
117Narrow palate (HP:0000189)1.92047970
118Stomatitis (HP:0010280)1.91715855
119Fatigue (HP:0012378)1.91437479
120Papilledema (HP:0001085)1.89897462
121Hyperglycemia (HP:0003074)1.89343216
122Aneurysm (HP:0002617)1.89131118
123Chest pain (HP:0100749)1.88607582
124Autoimmune hemolytic anemia (HP:0001890)1.88607068
125Thickened calvaria (HP:0002684)1.88368122
126Abnormality of purine metabolism (HP:0004352)1.87966443
127Abnormality of the frontal sinuses (HP:0002687)1.87733577
128Lower limb hyperreflexia (HP:0002395)1.86032546
129Abnormality of macrophages (HP:0004311)1.84996908
130Mucopolysacchariduria (HP:0008155)1.83848636
131Urinary glycosaminoglycan excretion (HP:0003541)1.83848636
132Neoplasm of the tracheobronchial system (HP:0100552)1.83087247
133Prolonged bleeding time (HP:0003010)1.82160818
134Broad ribs (HP:0000885)1.81555328
135Abnormal enzyme/coenzyme activity (HP:0012379)1.81372344
136Abnormality of iron homeostasis (HP:0011031)1.80819746
137Mediastinal lymphadenopathy (HP:0100721)1.80690603
138Abnormality of transition element cation homeostasis (HP:0011030)1.80020348
139Abnormality of the left ventricular outflow tract (HP:0011103)1.79956565
140Subaortic stenosis (HP:0001682)1.79956565
141Slow saccadic eye movements (HP:0000514)1.77978209
142Microcytic anemia (HP:0001935)1.77700586
143Hypochromic anemia (HP:0001931)1.77492288
144Symptomatic seizures (HP:0011145)1.76928278
145Genu recurvatum (HP:0002816)1.76405314
146Hypoplasia of the thymus (HP:0000778)1.75496943
147Abnormality of the right ventricle (HP:0001707)1.75109340
148Dysostosis multiplex (HP:0000943)1.74483586
149Increased CSF protein (HP:0002922)1.73827219
150Increased variability in muscle fiber diameter (HP:0003557)1.73648416
151Thyroid carcinoma (HP:0002890)1.72998204
152Cerebral aneurysm (HP:0004944)1.72753796
153Thin bony cortex (HP:0002753)1.72697726
154Cellulitis (HP:0100658)1.71320960
155Conjunctival telangiectasia (HP:0000524)1.70982707
156Vascular calcification (HP:0004934)1.70666593
157Lymphangioma (HP:0100764)1.70001036
158Coarse hair (HP:0002208)1.69810226
159Thrombocytosis (HP:0001894)1.69198853
160Joint laxity (HP:0001388)1.69025635
161Arterial thrombosis (HP:0004420)1.69020595
162Peritonitis (HP:0002586)1.68937824
163Pulmonic stenosis (HP:0001642)1.68770164
164Abnormality of skeletal muscle fiber size (HP:0012084)1.66607739
165Vasculitis (HP:0002633)1.66296608
166Stroke (HP:0001297)1.65399516
167Abnormality of polysaccharide metabolism (HP:0011012)1.65186435
168Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65186435
169Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65186435
170Ovoid vertebral bodies (HP:0003300)1.64664827
171Abnormal foot bone ossification (HP:0010675)1.64258995
172Osteomyelitis (HP:0002754)1.63322996
173Abnormality of alkaline phosphatase activity (HP:0004379)1.62826205
174Recurrent bacterial skin infections (HP:0005406)1.62796715
175Joint swelling (HP:0001386)1.62147737
176Leukocytosis (HP:0001974)1.62031656
177Vertebral compression fractures (HP:0002953)1.61996445
178Periodontitis (HP:0000704)1.61838166
179Recurrent viral infections (HP:0004429)1.61747362
180Acute myeloid leukemia (HP:0004808)1.61739399
181Upper motor neuron abnormality (HP:0002127)1.61599101
182Hemoptysis (HP:0002105)1.61526431

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PKN23.71899078
2ERN13.33713982
3TRIB33.03674298
4INSRR2.91260199
5FLT32.84274514
6TGFBR22.53141691
7PRPF4B2.47227604
8TAOK32.44973915
9MAP3K102.42106591
10FGFR42.40966547
11AKT32.26560791
12BMPR22.17016977
13SIK12.14921043
14ICK2.12999003
15PTK61.97160724
16MAP3K61.96660618
17IKBKE1.92019470
18TGFBR11.90013429
19RIPK41.77422568
20CSK1.73053002
21IRAK11.71569776
22MAP2K31.70689539
23TYK21.70264719
24CDK121.67038679
25DYRK1B1.46607269
26PDGFRA1.44062537
27RIPK11.42746855
28BCKDK1.42601833
29FGFR31.41032820
30BRD41.39125936
31MAP3K21.36683754
32NLK1.34847097
33PIK3CA1.34632352
34FRK1.33652859
35SGK21.31506908
36MAP4K11.31011518
37ERBB31.30223802
38FES1.30104391
39MYLK1.28354868
40SIK31.24181919
41CSF1R1.23696023
42LRRK21.23329285
43EPHB11.20978441
44CDK61.19265225
45IRAK41.17649697
46LATS11.17345200
47GRK61.16622053
48CAMK1D1.15552668
49MATK1.14840251
50EEF2K1.12815506
51TIE11.12019825
52MAPK151.10337434
53JAK31.10174804
54MAPK111.09947211
55CAMKK21.09568144
56BTK1.09480391
57EIF2AK31.06418994
58YES11.06051000
59JAK11.05014590
60EPHA31.03993241
61JAK21.02131889
62MAP3K71.01538978
63STK101.01460601
64KIT0.97707471
65DDR20.91308910
66MAP3K110.90263982
67FGFR20.86137247
68IKBKB0.85907057
69MAP3K140.85896151
70TBK10.85748712
71STK380.85235689
72ITK0.85154287
73CAMK1G0.84956548
74RET0.84054639
75ZAP700.84039860
76PIM10.84013989
77PRKAA20.83649665
78HIPK20.83096287
79STK30.82734410
80SYK0.79689003
81MAP2K60.78245425
82IRAK20.76884173
83TAOK20.75970988
84WNK10.75633196
85PDGFRB0.75515190
86MTOR0.74406315
87TEC0.74099379
88MAP3K10.73990122
89PAK30.73286286
90GRK70.73267657
91MELK0.73230375
92PRKD20.73189798
93MARK20.71550595
94BCR0.69950659
95MAPK40.69752777
96KSR20.68139377
97MAP3K120.68048756
98TRPM70.67567257
99STK38L0.67349816
100BLK0.67111008
101PIK3CG0.64751228
102CDK70.63870575
103TYRO30.63164629
104CHUK0.61592848
105FER0.60367583
106STK240.60307529
107PDK10.60027260
108RPS6KA60.59713241
109RPS6KL10.59252530
110RPS6KC10.59252530
111TNK20.58700091
112BMX0.58344619
113PTK20.58204404
114CLK10.58172102
115PTK2B0.57904712
116MAP2K40.57834718
117TXK0.56742281
118SGK30.55385775
119KSR10.54520868
120IRAK30.54504311
121NUAK10.54217507
122HCK0.53982988
123TAOK10.52529623
124PRKD10.52253235
125MAP3K30.51557364
126MAP3K130.51366879
127MAPK70.50023373
128NEK90.49827073
129FGR0.48977428
130ABL10.48647570
131CDK40.48622879
132RPS6KA20.48556401
133PRKAA10.48343522
134MAP3K50.48305821
135KDR0.47002950
136ACVR1B0.46736743
137LCK0.45504634
138PRKD30.45202036
139EGFR0.45189349
140PRKCH0.43136159
141LYN0.42734340
142MAPK120.42638643
143GSK3A0.41801286
144MAPK30.40937514
145TTN0.39791120

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.46458688
2Nitrogen metabolism_Homo sapiens_hsa009103.48472283
3Arginine biosynthesis_Homo sapiens_hsa002203.14272183
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.12928456
5Complement and coagulation cascades_Homo sapiens_hsa046103.10527347
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95589457
7Tryptophan metabolism_Homo sapiens_hsa003802.65238185
8Staphylococcus aureus infection_Homo sapiens_hsa051502.42052635
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24813906
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.15912781
11Fatty acid degradation_Homo sapiens_hsa000712.13753772
12Selenocompound metabolism_Homo sapiens_hsa004502.10274802
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.06709404
14Caffeine metabolism_Homo sapiens_hsa002322.06324708
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.03571507
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.88865983
17Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.83469559
18ABC transporters_Homo sapiens_hsa020101.81124261
19Drug metabolism - other enzymes_Homo sapiens_hsa009831.76334288
20Peroxisome_Homo sapiens_hsa041461.76325507
21PPAR signaling pathway_Homo sapiens_hsa033201.75718871
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62137989
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.62020179
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61857641
25Fatty acid metabolism_Homo sapiens_hsa012121.60179075
26Toll-like receptor signaling pathway_Homo sapiens_hsa046201.54990442
27Chemical carcinogenesis_Homo sapiens_hsa052041.54060687
28AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51464724
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.51305810
30TNF signaling pathway_Homo sapiens_hsa046681.48925729
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46304612
32Starch and sucrose metabolism_Homo sapiens_hsa005001.45932757
33Bile secretion_Homo sapiens_hsa049761.45294344
34Renal cell carcinoma_Homo sapiens_hsa052111.39116440
35Histidine metabolism_Homo sapiens_hsa003401.38899840
36Malaria_Homo sapiens_hsa051441.38317014
37Butanoate metabolism_Homo sapiens_hsa006501.38145669
38Lysine degradation_Homo sapiens_hsa003101.37694572
39T cell receptor signaling pathway_Homo sapiens_hsa046601.35163010
40Pancreatic cancer_Homo sapiens_hsa052121.34683270
41Measles_Homo sapiens_hsa051621.33918854
42Sulfur metabolism_Homo sapiens_hsa009201.33782951
43Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.33541854
44Fat digestion and absorption_Homo sapiens_hsa049751.33194740
45Prolactin signaling pathway_Homo sapiens_hsa049171.32036266
46Folate biosynthesis_Homo sapiens_hsa007901.30240692
47Propanoate metabolism_Homo sapiens_hsa006401.26595466
48Hepatitis B_Homo sapiens_hsa051611.26193904
49Tuberculosis_Homo sapiens_hsa051521.25810907
50Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.25281217
51Retinol metabolism_Homo sapiens_hsa008301.25226085
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.23722677
53beta-Alanine metabolism_Homo sapiens_hsa004101.19609012
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18500923
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.18332815
56FoxO signaling pathway_Homo sapiens_hsa040681.15865737
57Leukocyte transendothelial migration_Homo sapiens_hsa046701.14004768
58Neurotrophin signaling pathway_Homo sapiens_hsa047221.11470707
59Chemokine signaling pathway_Homo sapiens_hsa040621.10245704
60Prostate cancer_Homo sapiens_hsa052151.09473711
61Influenza A_Homo sapiens_hsa051641.09234395
62Endometrial cancer_Homo sapiens_hsa052131.07770375
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.07495521
64Shigellosis_Homo sapiens_hsa051311.02555686
65Hepatitis C_Homo sapiens_hsa051601.02358120
66Phenylalanine metabolism_Homo sapiens_hsa003601.01369089
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.98754822
68Small cell lung cancer_Homo sapiens_hsa052220.98306232
69African trypanosomiasis_Homo sapiens_hsa051430.97875314
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97063666
71Proteoglycans in cancer_Homo sapiens_hsa052050.96607453
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96494369
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.96190809
74One carbon pool by folate_Homo sapiens_hsa006700.94230794
75VEGF signaling pathway_Homo sapiens_hsa043700.91788007
76Hematopoietic cell lineage_Homo sapiens_hsa046400.91184835
77Glioma_Homo sapiens_hsa052140.91030558
78Biosynthesis of amino acids_Homo sapiens_hsa012300.89033571
79Inositol phosphate metabolism_Homo sapiens_hsa005620.88281198
80Tyrosine metabolism_Homo sapiens_hsa003500.86204069
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86113332
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85290164
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84073535
84Choline metabolism in cancer_Homo sapiens_hsa052310.83888472
85Colorectal cancer_Homo sapiens_hsa052100.83787476
86ErbB signaling pathway_Homo sapiens_hsa040120.83675402
87Fatty acid biosynthesis_Homo sapiens_hsa000610.83360308
88Allograft rejection_Homo sapiens_hsa053300.83039269
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.82039721
90Insulin resistance_Homo sapiens_hsa049310.81224743
91Circadian rhythm_Homo sapiens_hsa047100.81115239
92ECM-receptor interaction_Homo sapiens_hsa045120.80266225
93Salmonella infection_Homo sapiens_hsa051320.73854460
94Viral myocarditis_Homo sapiens_hsa054160.71879704
95MicroRNAs in cancer_Homo sapiens_hsa052060.71786411
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.71631785
97Pyruvate metabolism_Homo sapiens_hsa006200.71380570
98Herpes simplex infection_Homo sapiens_hsa051680.70647993
99Vitamin digestion and absorption_Homo sapiens_hsa049770.70628195
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70473158
101Phagosome_Homo sapiens_hsa041450.70010133
102Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69509343
103MAPK signaling pathway_Homo sapiens_hsa040100.68774110
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68342010
105Melanoma_Homo sapiens_hsa052180.67929947
106Autoimmune thyroid disease_Homo sapiens_hsa053200.67789921
107Graft-versus-host disease_Homo sapiens_hsa053320.67649520
108Apoptosis_Homo sapiens_hsa042100.66718949
109cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65351491
110GnRH signaling pathway_Homo sapiens_hsa049120.65031314
111Estrogen signaling pathway_Homo sapiens_hsa049150.64323145
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63977954
113Cyanoamino acid metabolism_Homo sapiens_hsa004600.63666920
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63224363
115Endocytosis_Homo sapiens_hsa041440.62767954
116Long-term potentiation_Homo sapiens_hsa047200.61475356
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61397511
118Type II diabetes mellitus_Homo sapiens_hsa049300.60477786
119Arginine and proline metabolism_Homo sapiens_hsa003300.59394564
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59263750
121Fatty acid elongation_Homo sapiens_hsa000620.57137461
122Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57070247
123Pathways in cancer_Homo sapiens_hsa052000.57007863
124Viral carcinogenesis_Homo sapiens_hsa052030.55908084
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55717458
126Steroid biosynthesis_Homo sapiens_hsa001000.55110582
127Glycerolipid metabolism_Homo sapiens_hsa005610.54481818
128Carbon metabolism_Homo sapiens_hsa012000.54303615
129Rap1 signaling pathway_Homo sapiens_hsa040150.53722338
130TGF-beta signaling pathway_Homo sapiens_hsa043500.53002842
131Other glycan degradation_Homo sapiens_hsa005110.52461448
132PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52421989
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51058384
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.46614617
135Sulfur relay system_Homo sapiens_hsa041220.43982771
136Galactose metabolism_Homo sapiens_hsa000520.43181183
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.43058808
138Acute myeloid leukemia_Homo sapiens_hsa052210.42692724
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39583363
140Leishmaniasis_Homo sapiens_hsa051400.37642465
141Primary immunodeficiency_Homo sapiens_hsa053400.36228502
142B cell receptor signaling pathway_Homo sapiens_hsa046620.32935716
143Pentose phosphate pathway_Homo sapiens_hsa000300.30675834
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.29711079
145mTOR signaling pathway_Homo sapiens_hsa041500.28745104
146Toxoplasmosis_Homo sapiens_hsa051450.28420403
147Pertussis_Homo sapiens_hsa051330.28382759
148Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.28078817
149AMPK signaling pathway_Homo sapiens_hsa041520.27876989
150Glucagon signaling pathway_Homo sapiens_hsa049220.26738225
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25935842
152Prion diseases_Homo sapiens_hsa050200.24098376
153Chronic myeloid leukemia_Homo sapiens_hsa052200.22786066
154Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22725450
155Legionellosis_Homo sapiens_hsa051340.21776656
156Non-small cell lung cancer_Homo sapiens_hsa052230.20709565
157Dorso-ventral axis formation_Homo sapiens_hsa043200.20451325
158Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20117269
159Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.19250128
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19201573
161Platelet activation_Homo sapiens_hsa046110.18731188
162Insulin signaling pathway_Homo sapiens_hsa049100.18644843
163Osteoclast differentiation_Homo sapiens_hsa043800.17735551
164Glutathione metabolism_Homo sapiens_hsa004800.17575061
165Adherens junction_Homo sapiens_hsa045200.17573488
166Amoebiasis_Homo sapiens_hsa051460.15756014
167Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.15528533
168NF-kappa B signaling pathway_Homo sapiens_hsa040640.14612635
169N-Glycan biosynthesis_Homo sapiens_hsa005100.13160370
170Central carbon metabolism in cancer_Homo sapiens_hsa052300.12977153
171Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.12536221
172Focal adhesion_Homo sapiens_hsa045100.12245460

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