FAM160B2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of molecule of bacterial origin (GO:0032490)7.99391567
2negative regulation of macroautophagy (GO:0016242)7.61151377
3auditory receptor cell stereocilium organization (GO:0060088)7.03582113
4positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)6.62774722
5post-embryonic morphogenesis (GO:0009886)6.26154286
6sulfate transmembrane transport (GO:1902358)5.56062581
7energy homeostasis (GO:0097009)5.55268222
8cellular anion homeostasis (GO:0030002)5.28969959
9detection of external biotic stimulus (GO:0098581)5.08560714
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.89357806
11inner ear receptor stereocilium organization (GO:0060122)4.75695037
12phosphate ion homeostasis (GO:0055062)4.69611187
13trivalent inorganic anion homeostasis (GO:0072506)4.69611187
14sulfate transport (GO:0008272)4.59698910
15mannose metabolic process (GO:0006013)4.55160684
16lateral ventricle development (GO:0021670)4.50522593
17negative regulation of meiosis (GO:0045835)4.40697179
18positive regulation of neurotransmitter secretion (GO:0001956)4.35558672
19detection of biotic stimulus (GO:0009595)4.35231135
20positive regulation of neurological system process (GO:0031646)4.19665004
21negative regulation of erythrocyte differentiation (GO:0045647)4.17258898
22regulation of tumor necrosis factor biosynthetic process (GO:0042534)4.10332525
23response to pheromone (GO:0019236)3.98462972
24neuron remodeling (GO:0016322)3.96826131
25bicarbonate transport (GO:0015701)3.84125484
26negative regulation of response to nutrient levels (GO:0032108)3.70305395
27negative regulation of response to extracellular stimulus (GO:0032105)3.70305395
28regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.65815515
29glycoside metabolic process (GO:0016137)3.59436575
30regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.55237881
31vocalization behavior (GO:0071625)3.42215004
32regulation of interleukin-6 biosynthetic process (GO:0045408)3.40795327
33positive regulation of neurotransmitter transport (GO:0051590)3.38258044
34positive regulation of vascular permeability (GO:0043117)3.38227020
35exogenous drug catabolic process (GO:0042738)3.33137030
36negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32377285
37positive regulation of CREB transcription factor activity (GO:0032793)3.27866809
38semaphorin-plexin signaling pathway (GO:0071526)3.24152841
39positive regulation of histone deacetylation (GO:0031065)3.20306706
40regulation of extracellular matrix disassembly (GO:0010715)3.11756594
41positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08923388
42regulation of ARF GTPase activity (GO:0032312)3.08844253
43prostate gland growth (GO:0060736)3.08052332
44sulfur compound transport (GO:0072348)3.07510682
45positive regulation of hormone biosynthetic process (GO:0046886)3.03610634
46daunorubicin metabolic process (GO:0044597)20.8591414
47polyketide metabolic process (GO:0030638)20.8591414
48doxorubicin metabolic process (GO:0044598)20.8591414
49positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.97061379
50estrogen biosynthetic process (GO:0006703)2.94284742
51regulation of glutamate receptor signaling pathway (GO:1900449)2.93863504
52negative regulation of granulocyte differentiation (GO:0030853)2.93267195
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.92232992
54positive regulation of uterine smooth muscle contraction (GO:0070474)2.91423752
55inositol metabolic process (GO:0006020)2.89742625
56positive regulation of protein sumoylation (GO:0033235)2.89187238
57peptidyl-lysine dimethylation (GO:0018027)2.89028846
58histone H3-K9 modification (GO:0061647)2.84442120
59maintenance of gastrointestinal epithelium (GO:0030277)2.83972279
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.81957607
61negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.81400668
62thymic T cell selection (GO:0045061)2.80592673
63positive thymic T cell selection (GO:0045059)2.79498115
64negative regulation of glial cell proliferation (GO:0060253)2.75729360
65tachykinin receptor signaling pathway (GO:0007217)2.70947010
66drinking behavior (GO:0042756)2.70645857
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.67310985
68regulation of ARF protein signal transduction (GO:0032012)2.66625853
69endothelial cell chemotaxis (GO:0035767)2.66579638
70positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64654070
71macrophage activation (GO:0042116)2.64049844
72regulation of activation of Janus kinase activity (GO:0010533)2.63951777
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.62353823
74negative regulation of meiotic cell cycle (GO:0051447)2.61546828
75cell proliferation involved in metanephros development (GO:0072203)2.61235529
76opioid receptor signaling pathway (GO:0038003)2.59607619
77antigen processing and presentation of endogenous antigen (GO:0019883)2.59281299
78cell-cell junction maintenance (GO:0045217)2.57806505
79activation of JUN kinase activity (GO:0007257)2.53234377
80negative regulation of cell killing (GO:0031342)2.52844372
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.52844372
82positive regulation of protein deacetylation (GO:0090312)2.52552755
83positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51625507
84response to muramyl dipeptide (GO:0032495)2.51335708
85long term synaptic depression (GO:0060292)2.51199427
86positive regulation of protein kinase C signaling (GO:0090037)2.50897848
87atrioventricular valve morphogenesis (GO:0003181)2.49133453
88negative regulation of cell size (GO:0045792)2.48318522
89positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)2.48033867
90G-protein coupled receptor internalization (GO:0002031)2.46884066
91cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.46381631
92glycine transport (GO:0015816)2.45394468
93adherens junction assembly (GO:0034333)2.43494546
94vascular endothelial growth factor signaling pathway (GO:0038084)2.43365215
95pigment granule localization (GO:0051875)2.42207291
96cell-substrate junction assembly (GO:0007044)2.41496950
97forebrain neuron differentiation (GO:0021879)2.40007722
98insulin-like growth factor receptor signaling pathway (GO:0048009)2.39552167
99venous blood vessel morphogenesis (GO:0048845)2.39142428
100protein heterotrimerization (GO:0070208)2.38441997
101drug catabolic process (GO:0042737)2.37030380
102response to laminar fluid shear stress (GO:0034616)2.36978238
103cell-substrate adherens junction assembly (GO:0007045)2.36848494
104focal adhesion assembly (GO:0048041)2.36848494
105germinal center formation (GO:0002467)2.36744342
106cell migration involved in heart development (GO:0060973)2.35692417
107regulation of uterine smooth muscle contraction (GO:0070472)2.35091505
108regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34971563
109negative regulation of calcium ion transport into cytosol (GO:0010523)2.34830635
110protein localization to endosome (GO:0036010)2.33256024
111negative regulation of autophagy (GO:0010507)2.32054144
112virion attachment to host cell (GO:0019062)2.31748770
113adhesion of symbiont to host cell (GO:0044650)2.31748770
114positive regulation of receptor recycling (GO:0001921)2.31197552
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.30480883
116G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.30237666
117stress fiber assembly (GO:0043149)2.29941294
118positive regulation of glycolytic process (GO:0045821)2.29867356
119negative regulation of fatty acid transport (GO:2000192)2.29793794
120somatic stem cell division (GO:0048103)2.28569047
121adhesion of symbiont to host (GO:0044406)2.26987314
122dendritic spine organization (GO:0097061)2.25731263
123positive regulation of protein dephosphorylation (GO:0035307)2.25002625
124desmosome organization (GO:0002934)2.24982198
125cerebral cortex radially oriented cell migration (GO:0021799)2.24192611
126hemidesmosome assembly (GO:0031581)2.23081053
127detection of chemical stimulus (GO:0009593)2.22799970
128vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.22469695
129head development (GO:0060322)2.22202753
130retrograde transport, endosome to Golgi (GO:0042147)2.21792970
131locomotory exploration behavior (GO:0035641)2.21663973
132response to fluid shear stress (GO:0034405)2.21433902
133regulation of B cell receptor signaling pathway (GO:0050855)2.20574342
134pigment granule transport (GO:0051904)2.20158639
135neuronal ion channel clustering (GO:0045161)2.19887020
136cell volume homeostasis (GO:0006884)2.19755991
137positive T cell selection (GO:0043368)2.19709825
138positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.19230393
139apoptotic process involved in morphogenesis (GO:0060561)2.17920736
140regulation of gamma-delta T cell differentiation (GO:0045586)2.17370103
141T cell selection (GO:0045058)2.16408635
142signal complex assembly (GO:0007172)2.16224247
143negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.15610821
144regulation of pigment cell differentiation (GO:0050932)2.15204286
145eye photoreceptor cell development (GO:0042462)2.15093617
146epithelial structure maintenance (GO:0010669)2.14776400
147regulation of gamma-delta T cell activation (GO:0046643)2.14486728
148regulation of synaptic vesicle exocytosis (GO:2000300)2.13776040
149positive regulation of gamma-delta T cell activation (GO:0046645)2.13695134
150azole transport (GO:0045117)2.12678350
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.12186707
152basement membrane organization (GO:0071711)2.11996471
153mesonephros development (GO:0001823)2.11544052
154cell proliferation involved in kidney development (GO:0072111)2.10789888
155regulation of extracellular matrix organization (GO:1903053)2.10250819
156NIK/NF-kappaB signaling (GO:0038061)2.09713308
157neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.09650918
158cell junction maintenance (GO:0034331)2.09606920
159sialylation (GO:0097503)2.09537724
160regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.09501721
161regulation of receptor internalization (GO:0002090)2.09415123
162tolerance induction (GO:0002507)2.08857193
163mRNA transcription from RNA polymerase II promoter (GO:0042789)2.08814023
164positive regulation of hormone metabolic process (GO:0032352)2.08236789
165establishment of pigment granule localization (GO:0051905)2.08206278
166barbed-end actin filament capping (GO:0051016)2.08070001
167positive regulation of Cdc42 GTPase activity (GO:0043089)2.08014990
168activation of MAPKKK activity (GO:0000185)2.06300974
169regulation of fatty acid beta-oxidation (GO:0031998)2.04803890
170histone H4 deacetylation (GO:0070933)2.04703078
171regulation of type I interferon-mediated signaling pathway (GO:0060338)2.04517273
172chondroitin sulfate catabolic process (GO:0030207)2.04092648
173peptidyl-tyrosine autophosphorylation (GO:0038083)2.03859658
174positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.03352533
175regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.01165651
176positive regulation of extracellular matrix organization (GO:1903055)2.01103312
177regulation of histone deacetylation (GO:0031063)2.00991264
178regulation of NFAT protein import into nucleus (GO:0051532)2.00193182
179regulation of T-helper 2 cell differentiation (GO:0045628)2.00177299
180aminoglycoside antibiotic metabolic process (GO:0030647)13.5959530
181cytoskeletal anchoring at plasma membrane (GO:0007016)1.98201178
182endocytic recycling (GO:0032456)1.97948629
183positive regulation of Rap GTPase activity (GO:0032854)1.96860791
184negative thymic T cell selection (GO:0045060)1.96719549
185detection of bacterium (GO:0016045)1.95515159
186negative regulation of type 2 immune response (GO:0002829)1.93268775
187regulation of early endosome to late endosome transport (GO:2000641)1.93226259
188negative regulation of Ras protein signal transduction (GO:0046580)1.91039961
189negative regulation of myotube differentiation (GO:0010832)1.90732864
190regulation of necroptotic process (GO:0060544)1.88309867
191histone H3 deacetylation (GO:0070932)1.87811958
192negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)1.87733019
193regulation of dendritic cell antigen processing and presentation (GO:0002604)1.87512413
194dermatan sulfate metabolic process (GO:0030205)1.86981416

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.59576014
2GBX2_23144817_ChIP-Seq_PC3_Human3.47378426
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.31625974
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.97240344
5* LXR_22292898_ChIP-Seq_THP-1_Human2.91281943
6KDM2B_26808549_Chip-Seq_SUP-B15_Human2.75713733
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70600999
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70503946
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.62942101
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54488163
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54488163
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.51892565
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.49377387
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48607666
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.43635996
16DROSHA_22980978_ChIP-Seq_HELA_Human2.42079955
17VDR_21846776_ChIP-Seq_THP-1_Human2.39539404
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.35250960
19SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33185407
20KDM2B_26808549_Chip-Seq_DND41_Human2.26054446
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24938455
22JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23387609
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21301188
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20324540
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.09901013
26RACK7_27058665_Chip-Seq_MCF-7_Human2.06258943
27SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05982453
28TCF7_22412390_ChIP-Seq_EML_Mouse2.03988636
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02846815
30KDM2B_26808549_Chip-Seq_K562_Human1.98456130
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.96023363
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.94970307
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93721489
34RXR_22108803_ChIP-Seq_LS180_Human1.89833759
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.86392643
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.85292825
37TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84427256
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84227441
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.81711201
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77666020
41REST_21632747_ChIP-Seq_MESCs_Mouse1.77517299
42SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.76571894
43EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.74673291
44MYC_22102868_ChIP-Seq_BL_Human1.74391615
45* P68_20966046_ChIP-Seq_HELA_Human1.72604165
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.71968497
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.71388652
48CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.65221980
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.64009793
50SA1_27219007_Chip-Seq_ERYTHROID_Human1.63703125
51SMC4_20622854_ChIP-Seq_HELA_Human1.63194275
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62678857
53CTCF_27219007_Chip-Seq_ERYTHROID_Human1.60133244
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.59124466
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55343860
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53781142
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53705473
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.53060765
59KDM2B_26808549_Chip-Seq_JURKAT_Human1.51844148
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.51817166
61VDR_24763502_ChIP-Seq_THP-1_Human1.50635585
62* CTCF_27219007_Chip-Seq_Bcells_Human1.50425024
63P300_19829295_ChIP-Seq_ESCs_Human1.49833767
64UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48949722
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.48476743
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.47418337
67PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47095887
68ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46293595
69IRF8_22096565_ChIP-ChIP_GC-B_Human1.46055422
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44338720
71RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.41160825
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.40209578
73CREB1_26743006_Chip-Seq_LNCaP_Human1.40182655
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.39415356
75ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35645465
76ELF1_20517297_ChIP-Seq_JURKAT_Human1.35272960
77SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35161721
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34819021
79VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33931378
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33736866
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33570449
82GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32612738
83* TP63_22573176_ChIP-Seq_HFKS_Human1.32019697
84TRIM28_21343339_ChIP-Seq_HEK293_Human1.31545928
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31370911
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.30319441
87BCOR_27268052_Chip-Seq_Bcells_Human1.29179627
88MAF_26560356_Chip-Seq_TH1_Human1.28939707
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28056630
90MAF_26560356_Chip-Seq_TH2_Human1.27869143
91BCL6_27268052_Chip-Seq_Bcells_Human1.26987466
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26938362
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.26845365
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26605446
95LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26567488
96CDX2_19796622_ChIP-Seq_MESCs_Mouse1.25687222
97SMAD4_21799915_ChIP-Seq_A2780_Human1.25270640
98VDR_22108803_ChIP-Seq_LS180_Human1.24546002
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23968785
100AR_25329375_ChIP-Seq_VCAP_Human1.23959939
101PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23393195
102P63_26484246_Chip-Seq_KERATINOCYTES_Human1.22862202
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.21457354
104ERG_21242973_ChIP-ChIP_JURKAT_Human1.21356306
105UTX_26944678_Chip-Seq_JUKART_Human1.20787264
106GATA1_19941827_ChIP-Seq_MEL_Mouse1.20491807
107TP53_22127205_ChIP-Seq_IMR90_Human1.20407235
108SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20338727
109P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18673731
110ESR1_21235772_ChIP-Seq_MCF-7_Human1.18148032
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16638884
112* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16021935
113* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15534189
114PIAS1_25552417_ChIP-Seq_VCAP_Human1.15392153
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14822244
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.14712563
117GATA1_19941826_ChIP-Seq_K562_Human1.14345014
118SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.13419574
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.12826241
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12629660
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12496657
122RNF2_27304074_Chip-Seq_NSC_Mouse1.11638681
123RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.10858218
124E2F1_18555785_Chip-Seq_ESCs_Mouse1.10350417
125POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08654794
126TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08654794
127SMAD3_21741376_ChIP-Seq_HESCs_Human1.08387085
128SA1_27219007_Chip-Seq_Bcells_Human1.08143613
129SPI1_23127762_ChIP-Seq_K562_Human1.07952179
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.07744553
131VDR_24787735_ChIP-Seq_THP-1_Human1.07048080
132TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06882881
133ZNF217_24962896_ChIP-Seq_MCF-7_Human1.06775398
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06598813
135TCF4_23295773_ChIP-Seq_U87_Human1.06588774
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06411887
137STAT3_23295773_ChIP-Seq_U87_Human1.06182185
138RING1B_27294783_Chip-Seq_NPCs_Mouse1.06160930
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05925729
140EP300_21415370_ChIP-Seq_HL-1_Mouse1.05907964
141CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05903063
142RUNX2_22187159_ChIP-Seq_PCA_Human1.05641086
143TET1_21490601_ChIP-Seq_MESCs_Mouse1.05315152
144EZH2_27294783_Chip-Seq_NPCs_Mouse1.05304507
145TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05135490
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.04705506
147SMAD4_21741376_ChIP-Seq_HESCs_Human1.04253712
148WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03633418
149CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03314201
150MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02891903
151E2F1_20622854_ChIP-Seq_HELA_Human1.02209012
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01915178
153SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01828739
154* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01602454
155PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01513362
156MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01495775
157SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01492622
158SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01102008
159TP53_20018659_ChIP-ChIP_R1E_Mouse0.99875516
160PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.99441221
161ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99348187
162STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.99166763
163* NCOR1_26117541_ChIP-Seq_K562_Human0.99157307
164CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99156506
165PHF8_20622854_ChIP-Seq_HELA_Human0.98701110
166TAF15_26573619_Chip-Seq_HEK293_Human0.98504359
167TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97997696
168P53_22387025_ChIP-Seq_ESCs_Mouse0.97814541
169NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97738487
170RARB_24833708_ChIP-Seq_LIVER_Mouse0.97433972
171MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96945422
172TP53_23651856_ChIP-Seq_MEFs_Mouse0.96713885
173EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96682116
174TBX20_22080862_ChIP-Seq_HEART_Mouse0.95410049
175TBX20_22328084_ChIP-Seq_HEART_Mouse0.95410049
176TBL1_22424771_ChIP-Seq_293T_Human0.95054251
177SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94748086
178TP53_18474530_ChIP-ChIP_U2OS_Human0.93993526
179AR_21572438_ChIP-Seq_LNCaP_Human0.93814008
180* RARB_27405468_Chip-Seq_BRAIN_Mouse0.92652992
181ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92465071
182POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92018006
183TP53_16413492_ChIP-PET_HCT116_Human0.91852358
184YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91393839
185CMYC_18555785_Chip-Seq_ESCs_Mouse0.90948789
186POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90819090
187AR_19668381_ChIP-Seq_PC3_Human0.90793406
188UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.90656263
189TCF4_22108803_ChIP-Seq_LS180_Human0.90269968
190KDM2B_26808549_Chip-Seq_REH_Human0.88795749
191SOX2_21211035_ChIP-Seq_LN229_Gbm0.88184505

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology7.60138445
2MP0005377_hearing/vestibular/ear_phenot7.60138445
3MP0008004_abnormal_stomach_pH6.67490631
4MP0003879_abnormal_hair_cell4.06541522
5MP0005645_abnormal_hypothalamus_physiol3.83497269
6MP0003705_abnormal_hypodermis_morpholog3.81246689
7MP0000678_abnormal_parathyroid_gland3.29339938
8MP0008438_abnormal_cutaneous_collagen3.19688902
9MP0003279_aneurysm3.06642722
10MP0003172_abnormal_lysosome_physiology3.05448360
11MP0005423_abnormal_somatic_nervous2.85531283
12MP0005058_abnormal_lysosome_morphology2.85289237
13MP0003646_muscle_fatigue2.80560520
14MP0001958_emphysema2.75582872
15MP0001485_abnormal_pinna_reflex2.73868957
16MP0009697_abnormal_copulation2.68662234
17MP0006292_abnormal_olfactory_placode2.55580505
18MP0004742_abnormal_vestibular_system2.54302233
19MP0000566_synostosis2.44370809
20MP0003436_decreased_susceptibility_to2.43717493
21MP0004859_abnormal_synaptic_plasticity2.33649668
22MP0005409_darkened_coat_color2.18808468
23MP0001486_abnormal_startle_reflex2.15334159
24MP0009840_abnormal_foam_cell2.14000724
25MP0003303_peritoneal_inflammation2.10432681
26MP0003880_abnormal_central_pattern2.06210241
27MP0000751_myopathy1.95586901
28MP0006276_abnormal_autonomic_nervous1.94472982
29MP0001986_abnormal_taste_sensitivity1.91559248
30MP0001849_ear_inflammation1.89702426
31MP0002933_joint_inflammation1.89478333
32MP0005275_abnormal_skin_tensile1.88827683
33MP0009384_cardiac_valve_regurgitation1.85238540
34MP0003941_abnormal_skin_development1.84051281
35MP0003300_gastrointestinal_ulcer1.83150313
36MP0001348_abnormal_lacrimal_gland1.77659652
37MP0004947_skin_inflammation1.76632616
38MP0002735_abnormal_chemical_nociception1.66788342
39MP0003091_abnormal_cell_migration1.60083412
40MP0009046_muscle_twitch1.58755005
41MP0002277_abnormal_respiratory_mucosa1.58066701
42MP0005670_abnormal_white_adipose1.56414588
43MP0005646_abnormal_pituitary_gland1.55905837
44MP0000003_abnormal_adipose_tissue1.55044761
45MP0001873_stomach_inflammation1.53984459
46MP0005375_adipose_tissue_phenotype1.51552787
47MP0004130_abnormal_muscle_cell1.50296171
48MP0000767_abnormal_smooth_muscle1.47963817
49MP0003329_amyloid_beta_deposits1.44592269
50MP0005666_abnormal_adipose_tissue1.42843992
51MP0000685_abnormal_immune_system1.42362921
52MP0003045_fibrosis1.42150036
53MP0009278_abnormal_bone_marrow1.42033445
54MP0000013_abnormal_adipose_tissue1.41144015
55MP0001440_abnormal_grooming_behavior1.40716150
56MP0001533_abnormal_skeleton_physiology1.39762336
57MP0002572_abnormal_emotion/affect_behav1.38592334
58MP0005451_abnormal_body_composition1.37958894
59MP0009745_abnormal_behavioral_response1.37643062
60MP0008260_abnormal_autophagy1.37297784
61MP0002557_abnormal_social/conspecific_i1.35026963
62MP0001968_abnormal_touch/_nociception1.34612342
63MP0001501_abnormal_sleep_pattern1.32242612
64MP0004381_abnormal_hair_follicle1.31806164
65MP0003453_abnormal_keratinocyte_physiol1.29345610
66MP0005023_abnormal_wound_healing1.28019997
67MP0003635_abnormal_synaptic_transmissio1.22514970
68MP0004858_abnormal_nervous_system1.20182691
69MP0002272_abnormal_nervous_system1.18404346
70MP0003724_increased_susceptibility_to1.18261952
71MP0003191_abnormal_cellular_cholesterol1.17968167
72MP0002132_abnormal_respiratory_system1.17943976
73MP0005360_urolithiasis1.14934290
74MP0001664_abnormal_digestion1.14262857
75MP0000604_amyloidosis1.13752353
76MP0002419_abnormal_innate_immunity1.12728983
77MP0003763_abnormal_thymus_physiology1.12369847
78MP0002184_abnormal_innervation1.11866847
79MP0010155_abnormal_intestine_physiology1.10197384
80MP0002060_abnormal_skin_morphology1.09740760
81MP0005076_abnormal_cell_differentiation1.09623234
82MP0002938_white_spotting1.09572598
83MP0005390_skeleton_phenotype1.07633214
84MP0002064_seizures1.07427297
85MP0005025_abnormal_response_to1.07130023
86MP0004924_abnormal_behavior0.99503917
87MP0005386_behavior/neurological_phenoty0.99503917
88MP0005000_abnormal_immune_tolerance0.99427550
89MP0001800_abnormal_humoral_immune0.94773450
90MP0008874_decreased_physiological_sensi0.94409242
91MP0002971_abnormal_brown_adipose0.94240477
92MP0000681_abnormal_thyroid_gland0.94163538
93MP0003690_abnormal_glial_cell0.93237014
94MP0004185_abnormal_adipocyte_glucose0.93131317
95MP0002249_abnormal_larynx_morphology0.92886055
96MP0003183_abnormal_peptide_metabolism0.91583679
97MP0006082_CNS_inflammation0.90826017
98MP0000733_abnormal_muscle_development0.90798252
99MP0004085_abnormal_heartbeat0.90309745
100MP0005508_abnormal_skeleton_morphology0.89675614
101MP0002736_abnormal_nociception_after0.89657861
102MP0005595_abnormal_vascular_smooth0.89588537
103MP0001346_abnormal_lacrimal_gland0.87736296
104MP0009333_abnormal_splenocyte_physiolog0.86697697
105MP0004272_abnormal_basement_membrane0.86623708
106MP0001963_abnormal_hearing_physiology0.86466803
107MP0000470_abnormal_stomach_morphology0.86353848
108MP0002896_abnormal_bone_mineralization0.83949361
109MP0005171_absent_coat_pigmentation0.82929492
110MP0000249_abnormal_blood_vessel0.82854479
111MP0000858_altered_metastatic_potential0.81484081
112MP0002405_respiratory_system_inflammati0.81311039
113MP0002163_abnormal_gland_morphology0.80701040
114MP0002723_abnormal_immune_serum0.80378846
115MP0002108_abnormal_muscle_morphology0.80363926
116MP0002063_abnormal_learning/memory/cond0.79099816
117MP0001835_abnormal_antigen_presentation0.78837677
118MP0002067_abnormal_sensory_capabilities0.78551648
119MP0005310_abnormal_salivary_gland0.78078909
120MP0001970_abnormal_pain_threshold0.77135103
121MP0004084_abnormal_cardiac_muscle0.75602338
122MP0010368_abnormal_lymphatic_system0.75090560
123MP0003795_abnormal_bone_structure0.74852112
124MP0000759_abnormal_skeletal_muscle0.74585767
125MP0005464_abnormal_platelet_physiology0.74337589
126MP0001819_abnormal_immune_cell0.73551249
127MP0002420_abnormal_adaptive_immunity0.73477711
128MP0003075_altered_response_to0.72878211
129MP0004885_abnormal_endolymph0.72434712
130MP0005647_abnormal_sex_gland0.72431277
131MP0002452_abnormal_antigen_presenting0.72095814
132MP0003868_abnormal_feces_composition0.70956630
133MP0002970_abnormal_white_adipose0.70603611
134MP0001324_abnormal_eye_pigmentation0.70294228
135MP0002098_abnormal_vibrissa_morphology0.69580518
136MP0001663_abnormal_digestive_system0.68067734
137MP0004233_abnormal_muscle_weight0.67901099
138MP0009931_abnormal_skin_appearance0.67622179
139MP0001502_abnormal_circadian_rhythm0.67573470
140MP0009115_abnormal_fat_cell0.66779830
141MP0005167_abnormal_blood-brain_barrier0.66117954
142MP0001243_abnormal_dermal_layer0.65900210
143MP0002998_abnormal_bone_remodeling0.65830100
144MP0008569_lethality_at_weaning0.65459909
145MP0001542_abnormal_bone_strength0.65195381
146MP0004134_abnormal_chest_morphology0.64419865
147MP0002796_impaired_skin_barrier0.64396979
148MP0004510_myositis0.63950451
149MP0010386_abnormal_urinary_bladder0.63057324
150MP0002734_abnormal_mechanical_nocicepti0.62115416
151MP0000026_abnormal_inner_ear0.61927822
152MP0008775_abnormal_heart_ventricle0.60391163
153MP0002638_abnormal_pupillary_reflex0.59435483
154MP0001293_anophthalmia0.58138350
155MP0002396_abnormal_hematopoietic_system0.56098957
156MP0004036_abnormal_muscle_relaxation0.55537743
157MP0009780_abnormal_chondrocyte_physiolo0.54843835
158MP0006138_congestive_heart_failure0.54455616
159MP0005257_abnormal_intraocular_pressure0.54288674
160MP0004484_altered_response_of0.53606874
161MP0003566_abnormal_cell_adhesion0.53266782
162MP0003938_abnormal_ear_development0.52927604
163MP0002127_abnormal_cardiovascular_syste0.52836853
164MP0003385_abnormal_body_wall0.50134258
165MP0004043_abnormal_pH_regulation0.48835751
166MP0005503_abnormal_tendon_morphology0.46696438
167MP0000516_abnormal_urinary_system0.46262637
168MP0005367_renal/urinary_system_phenotyp0.46262637
169MP0002102_abnormal_ear_morphology0.45976304
170MP0005387_immune_system_phenotype0.45599311
171MP0001790_abnormal_immune_system0.45599311
172MP0002075_abnormal_coat/hair_pigmentati0.44240697
173MP0001765_abnormal_ion_homeostasis0.41910128
174MP0001529_abnormal_vocalization0.41898360
175MP0002066_abnormal_motor_capabilities/c0.41800624
176MP0002069_abnormal_eating/drinking_beha0.41201568
177MP0002733_abnormal_thermal_nociception0.41041273
178MP0004782_abnormal_surfactant_physiolog0.41035096
179MP0004811_abnormal_neuron_physiology0.40622565
180MP0000639_abnormal_adrenal_gland0.37136037
181MP0003936_abnormal_reproductive_system0.36392504

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)8.87455850
2Alopecia of scalp (HP:0002293)8.80918440
3Follicular hyperkeratosis (HP:0007502)7.64913088
4Bilateral sensorineural hearing impairment (HP:0008619)7.44929431
5Abnormality of dental color (HP:0011073)6.94254952
6Absent eyebrow (HP:0002223)6.47326443
7Absent/shortened dynein arms (HP:0200106)6.30433886
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.30433886
9Absent eyelashes (HP:0000561)6.09559600
10Cheilitis (HP:0100825)5.83588722
11Chronic otitis media (HP:0000389)5.53818107
12Recurrent corneal erosions (HP:0000495)5.41832444
13Hyperphosphatemia (HP:0002905)4.64567157
14Abolished electroretinogram (ERG) (HP:0000550)4.20691589
15Obstructive sleep apnea (HP:0002870)4.10613731
16Protrusio acetabuli (HP:0003179)3.83158300
17Ectropion (HP:0000656)3.79191895
18Erythroderma (HP:0001019)3.78899875
19Abnormal ciliary motility (HP:0012262)3.71705198
20Renal dysplasia (HP:0000110)3.70890868
21Cervical subluxation (HP:0003308)3.70372625
22Tetany (HP:0001281)3.60383753
23Abnormal respiratory motile cilium morphology (HP:0005938)3.54360628
24Abnormal respiratory epithelium morphology (HP:0012253)3.54360628
25Cerebral aneurysm (HP:0004944)3.46935009
26Broad face (HP:0000283)3.35584048
27Absent hair (HP:0002298)3.24562603
28Premature rupture of membranes (HP:0001788)3.24513858
29Thin bony cortex (HP:0002753)3.13911994
30Chronic sinusitis (HP:0011109)3.10904855
31Blepharitis (HP:0000498)3.00879302
32Dysostosis multiplex (HP:0000943)2.92566424
33Urinary glycosaminoglycan excretion (HP:0003541)2.88510855
34Mucopolysacchariduria (HP:0008155)2.88510855
35Abnormality of mucopolysaccharide metabolism (HP:0011020)2.86866441
36Abnormality of polysaccharide metabolism (HP:0011012)2.86866441
37Abnormality of glycosaminoglycan metabolism (HP:0004371)2.86866441
38Abnormal respiratory motile cilium physiology (HP:0012261)2.81140653
39Stridor (HP:0010307)2.79710269
40Palmoplantar hyperkeratosis (HP:0000972)2.77102228
41Keratitis (HP:0000491)2.74956389
42J-shaped sella turcica (HP:0002680)2.73667522
43Neoplasm of the lung (HP:0100526)2.69982039
44Atrophic scars (HP:0001075)2.69657092
45Joint stiffness (HP:0001387)2.69485957
46Rhinitis (HP:0012384)2.66350145
47Palmar hyperkeratosis (HP:0010765)2.62545184
48Abnormality of calcium-phosphate metabolism (HP:0100530)2.62478495
49Fragile skin (HP:0001030)2.60188517
50Mitral stenosis (HP:0001718)2.59376133
51Vertebral arch anomaly (HP:0008438)2.57548765
52Aortic aneurysm (HP:0004942)2.51797416
53Shallow orbits (HP:0000586)2.49989151
54Increased connective tissue (HP:0009025)2.46781601
55Emphysema (HP:0002097)2.45070596
56Increased IgE level (HP:0003212)2.45059482
57Aneurysm (HP:0002617)2.45045664
58Mitral regurgitation (HP:0001653)2.44702469
59Broad metatarsal (HP:0001783)2.43516324
60Increased variability in muscle fiber diameter (HP:0003557)2.41863998
61Chronic hepatic failure (HP:0100626)2.36555461
62Lymphangioma (HP:0100764)2.36462692
63Vertigo (HP:0002321)2.35365457
64Aortic regurgitation (HP:0001659)2.34975124
65Biconcave vertebral bodies (HP:0004586)2.33772870
66Asymmetric septal hypertrophy (HP:0001670)2.31558855
67Erythema (HP:0010783)2.31231092
68Plagiocephaly (HP:0001357)2.30176174
69Bladder diverticulum (HP:0000015)2.30111067
70Small epiphyses (HP:0010585)2.29707902
71Focal motor seizures (HP:0011153)2.29145451
72Neoplasm of the respiratory system (HP:0100606)2.27101576
73Eczematoid dermatitis (HP:0000976)2.26653242
74Mildly elevated creatine phosphokinase (HP:0008180)2.25178509
75Corneal erosion (HP:0200020)2.24396911
76Distal upper limb amyotrophy (HP:0007149)2.23535822
77Upper limb amyotrophy (HP:0009129)2.23535822
78Hemorrhage of the eye (HP:0011885)2.23333626
79Disproportionate tall stature (HP:0001519)2.21323790
80Abnormal biliary tract physiology (HP:0012439)2.20752401
81Bile duct proliferation (HP:0001408)2.20752401
82Type 1 muscle fiber predominance (HP:0003803)2.17631505
83Dilatation of the ascending aorta (HP:0005111)2.16094949
84Hyperactive renin-angiotensin system (HP:0000841)2.15720141
85Malnutrition (HP:0004395)2.14293871
86Congenital sensorineural hearing impairment (HP:0008527)2.09994089
87Distal lower limb amyotrophy (HP:0008944)2.09675816
88Abnormality of the nasal mucosa (HP:0000433)2.09425666
89Hypoplasia of the capital femoral epiphysis (HP:0003090)2.08734785
90Aortic dissection (HP:0002647)2.08369363
91Systemic lupus erythematosus (HP:0002725)2.07921857
92Abnormality of incisor morphology (HP:0011063)2.06276676
93Nuclear cataract (HP:0100018)2.05862874
94Metabolic alkalosis (HP:0200114)2.05565206
95Blue sclerae (HP:0000592)2.05389771
96Hyperacusis (HP:0010780)2.04584433
97Spinal rigidity (HP:0003306)2.03577448
98Urticaria (HP:0001025)2.03279037
99Plantar hyperkeratosis (HP:0007556)2.03017142
100Spinal canal stenosis (HP:0003416)2.02750594
101Atelectasis (HP:0100750)2.01528139
102Atrial fibrillation (HP:0005110)2.01340768
103Parakeratosis (HP:0001036)10.2351722
104Renal agenesis (HP:0000104)1.99975740
105Distal lower limb muscle weakness (HP:0009053)1.99857000
106Vertebral compression fractures (HP:0002953)1.99826946
107Peritonitis (HP:0002586)1.98533265
108Supranuclear gaze palsy (HP:0000605)1.98150693
109Amelogenesis imperfecta (HP:0000705)1.98100817
110Easy fatigability (HP:0003388)1.96646671
111Abnormality of the renal collecting system (HP:0004742)1.94774967
112Rectal prolapse (HP:0002035)1.92926727
113Septo-optic dysplasia (HP:0100842)1.92177519
114Abnormality of skeletal muscle fiber size (HP:0012084)1.90421774
115Flat acetabular roof (HP:0003180)1.89692371
116Abnormality of the right ventricle (HP:0001707)1.87802753
117Osteomalacia (HP:0002749)1.86482271
118Primary atrial arrhythmia (HP:0001692)1.86299756
119Corneal dystrophy (HP:0001131)1.85366654
120White forelock (HP:0002211)1.83925667
121Genu recurvatum (HP:0002816)1.83754569
122Joint laxity (HP:0001388)1.83743262
123Vascular tortuosity (HP:0004948)1.83110683
124Hypohidrosis (HP:0000966)1.82948042
125Patchy hypopigmentation of hair (HP:0011365)1.82303114
126Exercise-induced myalgia (HP:0003738)1.81870487
127Febrile seizures (HP:0002373)1.81387862
128Ulnar deviation of the wrist (HP:0003049)1.80652190
129Ectopic kidney (HP:0000086)1.80055294
130Neurofibrillary tangles (HP:0002185)1.79878029
131Hyperaldosteronism (HP:0000859)1.78659193
132Premature skin wrinkling (HP:0100678)1.78407252
133Arthropathy (HP:0003040)1.77649657
134Annular pancreas (HP:0001734)1.77641994
135Hypoventilation (HP:0002791)1.75544877
136Slender build (HP:0001533)1.75480060
137Duplicated collecting system (HP:0000081)1.75275070
138Turricephaly (HP:0000262)1.75243032
139Mitral valve prolapse (HP:0001634)1.74796369
140Supraventricular tachycardia (HP:0004755)1.73338779
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72892642
142Deformed sella turcica (HP:0002681)1.72813971
143Ulnar claw (HP:0001178)1.72637459
144Sparse eyelashes (HP:0000653)1.71766836
145Myositis (HP:0100614)1.71631391
146Spondylolisthesis (HP:0003302)1.70596260
147Pustule (HP:0200039)1.69795204
148Wormian bones (HP:0002645)1.68804609
149Myopathic facies (HP:0002058)1.68192177
150Melanoma (HP:0002861)1.67970544
151Difficulty climbing stairs (HP:0003551)1.66385221
152Supraventricular arrhythmia (HP:0005115)1.66372118
153Nasal polyposis (HP:0100582)1.66333844
154Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.65898747
155Oligodontia (HP:0000677)1.65793599
156Hypercortisolism (HP:0001578)1.65649399
157Arterial tortuosity (HP:0005116)1.65474815
158Abnormality of the thoracic spine (HP:0100711)1.65260459
159Colitis (HP:0002583)1.65231452
160Loss of speech (HP:0002371)1.65111300
161Abnormality of renin-angiotensin system (HP:0000847)1.64566646
162Round ear (HP:0100830)1.64234432
163Conical tooth (HP:0000698)1.64000039
164Interstitial pulmonary disease (HP:0006530)1.63878518
165Hypocalcemia (HP:0002901)1.63726907
166Cellulitis (HP:0100658)1.63638362
167Polygenic inheritance (HP:0010982)1.62908942
168Absent epiphyses (HP:0010577)1.62611024
169Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62611024
170Spontaneous hematomas (HP:0007420)1.61794930
171Gingivitis (HP:0000230)1.61501628
172Abnormality of the fingertips (HP:0001211)1.59838716
173Bronchomalacia (HP:0002780)1.59475221
174Fetal akinesia sequence (HP:0001989)1.58174743
175Papilledema (HP:0001085)1.58065347
176Axonal loss (HP:0003447)1.57045866
177Long palpebral fissure (HP:0000637)1.57005090
178Ulnar bowing (HP:0003031)1.56952008
179Widely spaced teeth (HP:0000687)1.56743734
180Aortic valve stenosis (HP:0001650)1.56734268
181Syncope (HP:0001279)1.55990094
182Hypoparathyroidism (HP:0000829)1.55802178
183Centrally nucleated skeletal muscle fibers (HP:0003687)1.55286702
184Abnormality of chloride homeostasis (HP:0011422)1.54992943
185Supernumerary nipples (HP:0002558)1.53679148
186Microdontia (HP:0000691)1.52906222
187Lymphopenia (HP:0001888)1.51950955
188Aplasia cutis congenita (HP:0001057)1.50634304
189Coronal craniosynostosis (HP:0004440)1.50618855
190Malignant hyperthermia (HP:0002047)1.50600419
191Hypergonadotropic hypogonadism (HP:0000815)1.49453172
192Convex nasal ridge (HP:0000444)1.44138619
193Oligohydramnios (HP:0001562)1.41702741
194Limited hip movement (HP:0008800)1.40439324
195Cutaneous finger syndactyly (HP:0010554)1.39763268
196Midline defect of the nose (HP:0004122)1.39534092
197Atrioventricular block (HP:0001678)1.39166974
198Abnormality of cells of the lymphoid lineage (HP:0012140)1.37921704
199Prostate neoplasm (HP:0100787)1.36230680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK39.77237008
2SIK27.02951280
3SIK16.12541884
4TRIB34.13548172
5MARK33.33472253
6ERN13.24372485
7RIPK12.70947331
8EPHA22.59574931
9LATS12.06646002
10EPHB11.92802284
11PAK41.87946617
12CDC42BPA1.87773059
13EPHA41.86635675
14PRKD21.84781134
15FGFR41.82525446
16MAP2K31.72990507
17MARK21.70670860
18CDK81.68583562
19ICK1.63554862
20MAP3K121.62994086
21TNIK1.56951497
22MAP3K61.55690145
23MAP3K101.51957432
24NTRK31.51129452
25PKN21.49366370
26STK381.49264317
27PDGFRA1.48766328
28SMG11.46792766
29TYK21.39402086
30ZAP701.37871821
31TXK1.36940920
32STK38L1.36696193
33PRPF4B1.35032052
34DDR21.34193221
35WNK11.30101862
36RIPK41.23506750
37ADRBK21.23429628
38EEF2K1.21103806
39MAP3K131.18508171
40CAMK11.17744432
41MAP2K61.15317888
42MAPK151.15171451
43HIPK21.13865675
44TBK11.12945087
45RPS6KA21.11790343
46TYRO31.10282124
47MAP3K31.08903058
48LATS21.07071795
49MAPK130.99742302
50PTK60.98389816
51CAMKK10.96665473
52PDPK10.93911363
53NTRK10.92710199
54GRK60.89858754
55SGK20.88925833
56MST1R0.86291124
57IRAK30.86270947
58MTOR0.83846388
59FGFR30.83584411
60PTK20.83475555
61INSRR0.81455956
62CAMK40.81348293
63TNK20.80634424
64BTK0.80491791
65MAP3K10.80220071
66DYRK1B0.79902120
67TAOK10.78854450
68PDGFRB0.76454657
69BMX0.75307746
70KIT0.74630538
71CDK120.73958080
72MAP2K40.72956906
73EPHA30.72267903
74PDK10.71515559
75CSK0.70516905
76MAP2K70.69821106
77MAP2K20.67974293
78RET0.66651913
79TESK10.64137887
80PRKD10.63285196
81SGK30.62290091
82CSNK1D0.61404291
83MAPKAPK30.61210148
84TAOK20.59293259
85MAP3K70.57883760
86BRD40.57282457
87MAP3K140.54997884
88PRKAA20.54407268
89CASK0.53336811
90NTRK20.52632253
91CHUK0.52419332
92CAMK1G0.50250670
93IKBKE0.50073153
94KSR20.49836929
95SGK4940.48888405
96SGK2230.48888405
97LMTK20.48384683
98MET0.48065725
99SGK10.48021383
100IKBKB0.47795147
101PRKAA10.47730976
102GRK70.46678110
103PTK2B0.45312270
104MAPK40.44591080
105UHMK10.43289018
106CSNK1A1L0.42894694
107MYLK0.42290762
108LCK0.42281266
109PRKD30.41860502
110PRKG10.38428506
111MAP4K10.37920184
112PRKG20.37836010
113JAK20.37174543
114ALK0.36974883
115FES0.35796996
116MAP3K40.35793658
117DMPK0.35373201
118CAMK1D0.32810747
119MAPK120.31940669
120ZAK0.31377729
121PKN10.31199738
122HCK0.30414098
123MAPK110.27743754
124BLK0.27452817
125SRPK10.27295507
126TEC0.27140018
127TGFBR20.26432859
128DAPK20.25272329
129PRKCQ0.24634877
130RPS6KC10.24485444
131RPS6KL10.24485444
132BMPR20.24105117
133FGR0.23171547
134PHKG20.22926945
135PHKG10.22926945
136YES10.22108565
137SYK0.21988432
138MAP3K110.21391328
139STK30.21240465
140CAMK2A0.20437754
141LYN0.19359802
142CDK70.18806206
143IRAK40.18715352
144FYN0.18384503
145BMPR1B0.18165152
146CDK30.17822663
147IRAK20.17675753
148ITK0.17447386
149MAPK70.16785110
150RPS6KA60.16499764
151MUSK0.15304918
152SRC0.14975414
153STK110.14888428
154CDK50.14410477
155MAP3K50.14149166
156AKT10.14054047
157PRKCH0.13805248
158JAK10.13715657
159PIK3CA0.13631214
160PRKCE0.13203352
161JAK30.12507658
162TTN0.12491167
163OBSCN0.11809586
164EPHB20.11565642

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.50694716
2Other glycan degradation_Homo sapiens_hsa005112.95513301
3Mineral absorption_Homo sapiens_hsa049782.50990246
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.23167082
5Morphine addiction_Homo sapiens_hsa050322.22237086
6Calcium signaling pathway_Homo sapiens_hsa040202.21892544
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.08058740
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.03767695
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83595094
10Taste transduction_Homo sapiens_hsa047421.83429023
11Circadian entrainment_Homo sapiens_hsa047131.83092082
12Glutamatergic synapse_Homo sapiens_hsa047241.79187576
13Type II diabetes mellitus_Homo sapiens_hsa049301.76463762
14GABAergic synapse_Homo sapiens_hsa047271.75433613
15Axon guidance_Homo sapiens_hsa043601.74672900
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68048529
17Primary immunodeficiency_Homo sapiens_hsa053401.67201394
18Acute myeloid leukemia_Homo sapiens_hsa052211.61558101
19Serotonergic synapse_Homo sapiens_hsa047261.57928952
20Synaptic vesicle cycle_Homo sapiens_hsa047211.54406868
21VEGF signaling pathway_Homo sapiens_hsa043701.52123209
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.43396321
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.41720063
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.38539892
25Gastric acid secretion_Homo sapiens_hsa049711.31317262
26Salivary secretion_Homo sapiens_hsa049701.30389004
27Insulin secretion_Homo sapiens_hsa049111.29930978
28Renin secretion_Homo sapiens_hsa049241.28962264
29Dilated cardiomyopathy_Homo sapiens_hsa054141.28007779
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26437893
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.25550417
32Cholinergic synapse_Homo sapiens_hsa047251.24686111
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24569707
34Lysine degradation_Homo sapiens_hsa003101.22762827
35Olfactory transduction_Homo sapiens_hsa047401.22700586
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22169483
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.20545570
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19712123
39Melanoma_Homo sapiens_hsa052181.17938011
40Chronic myeloid leukemia_Homo sapiens_hsa052201.17845030
41Renal cell carcinoma_Homo sapiens_hsa052111.16264626
42ECM-receptor interaction_Homo sapiens_hsa045121.15542056
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13211287
44Neurotrophin signaling pathway_Homo sapiens_hsa047221.12831681
45Oxytocin signaling pathway_Homo sapiens_hsa049211.11587434
46Circadian rhythm_Homo sapiens_hsa047101.11015113
47cAMP signaling pathway_Homo sapiens_hsa040241.10343568
48Long-term potentiation_Homo sapiens_hsa047201.10303881
49African trypanosomiasis_Homo sapiens_hsa051431.10088154
50Hematopoietic cell lineage_Homo sapiens_hsa046401.09956614
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09904863
52Ovarian steroidogenesis_Homo sapiens_hsa049131.09900357
53Focal adhesion_Homo sapiens_hsa045101.09664154
54Toxoplasmosis_Homo sapiens_hsa051451.09612178
55Lysosome_Homo sapiens_hsa041421.07928599
56TNF signaling pathway_Homo sapiens_hsa046681.07741288
57ErbB signaling pathway_Homo sapiens_hsa040121.06877758
58Amoebiasis_Homo sapiens_hsa051461.05058349
59Ras signaling pathway_Homo sapiens_hsa040141.04363261
60Staphylococcus aureus infection_Homo sapiens_hsa051501.01901980
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.01718815
62Notch signaling pathway_Homo sapiens_hsa043301.00997588
63Long-term depression_Homo sapiens_hsa047301.00817268
64mTOR signaling pathway_Homo sapiens_hsa041501.00090963
65Insulin resistance_Homo sapiens_hsa049310.99920428
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99557835
67T cell receptor signaling pathway_Homo sapiens_hsa046600.97279642
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.97030566
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96450943
70Prolactin signaling pathway_Homo sapiens_hsa049170.96316429
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95752008
72Amphetamine addiction_Homo sapiens_hsa050310.94038026
73Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92525027
74Cocaine addiction_Homo sapiens_hsa050300.91753260
75Tuberculosis_Homo sapiens_hsa051520.91137236
76Glycerophospholipid metabolism_Homo sapiens_hsa005640.89893040
77Hepatitis C_Homo sapiens_hsa051600.89803236
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89416404
79Non-small cell lung cancer_Homo sapiens_hsa052230.88953442
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.87699368
81Insulin signaling pathway_Homo sapiens_hsa049100.87435048
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.86414653
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85883916
84Rap1 signaling pathway_Homo sapiens_hsa040150.85116263
85MAPK signaling pathway_Homo sapiens_hsa040100.84294074
86Wnt signaling pathway_Homo sapiens_hsa043100.84197220
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84190523
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83727942
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82928978
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82784966
91Prion diseases_Homo sapiens_hsa050200.82417099
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81923420
93Dopaminergic synapse_Homo sapiens_hsa047280.81216273
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.79597627
95Pertussis_Homo sapiens_hsa051330.79368225
96Osteoclast differentiation_Homo sapiens_hsa043800.79178229
97Protein digestion and absorption_Homo sapiens_hsa049740.78655594
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.78632892
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78114945
100Inositol phosphate metabolism_Homo sapiens_hsa005620.78112085
101Fructose and mannose metabolism_Homo sapiens_hsa000510.76459514
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75930982
103Intestinal immune network for IgA production_Homo sapiens_hsa046720.75838683
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75586851
105Malaria_Homo sapiens_hsa051440.74992448
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74938183
107Influenza A_Homo sapiens_hsa051640.74602536
108ABC transporters_Homo sapiens_hsa020100.73691355
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73421385
110Allograft rejection_Homo sapiens_hsa053300.73074399
111Endocytosis_Homo sapiens_hsa041440.72513870
112Choline metabolism in cancer_Homo sapiens_hsa052310.70815316
113Bladder cancer_Homo sapiens_hsa052190.70611432
114AMPK signaling pathway_Homo sapiens_hsa041520.69445586
115Pancreatic secretion_Homo sapiens_hsa049720.68806566
116Chemokine signaling pathway_Homo sapiens_hsa040620.68413871
117PPAR signaling pathway_Homo sapiens_hsa033200.67828664
118Measles_Homo sapiens_hsa051620.67525294
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.66206037
120Autoimmune thyroid disease_Homo sapiens_hsa053200.66184557
121Dorso-ventral axis formation_Homo sapiens_hsa043200.65936894
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65252503
123Pancreatic cancer_Homo sapiens_hsa052120.65217526
124Glycerolipid metabolism_Homo sapiens_hsa005610.63983198
125Leishmaniasis_Homo sapiens_hsa051400.63896598
126Hepatitis B_Homo sapiens_hsa051610.62782981
127Vascular smooth muscle contraction_Homo sapiens_hsa042700.61801190
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.61635454
129Melanogenesis_Homo sapiens_hsa049160.60889460
130Endometrial cancer_Homo sapiens_hsa052130.59116053
131Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58332131
132Graft-versus-host disease_Homo sapiens_hsa053320.57886535
133Proteoglycans in cancer_Homo sapiens_hsa052050.56454419
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.55942842
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.55608542
136FoxO signaling pathway_Homo sapiens_hsa040680.55383169
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53093744
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.52870658
139Small cell lung cancer_Homo sapiens_hsa052220.52164906
140GnRH signaling pathway_Homo sapiens_hsa049120.51555243
141Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51130569
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49294524
143Glioma_Homo sapiens_hsa052140.48730341
144Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47645009
145MicroRNAs in cancer_Homo sapiens_hsa052060.46844696
146Platelet activation_Homo sapiens_hsa046110.46043908
147Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45685390
148B cell receptor signaling pathway_Homo sapiens_hsa046620.45441825
149Salmonella infection_Homo sapiens_hsa051320.45244337
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44601370
151HTLV-I infection_Homo sapiens_hsa051660.43801992
152Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43687624
153Adherens junction_Homo sapiens_hsa045200.43243814
154Estrogen signaling pathway_Homo sapiens_hsa049150.43121119
155Leukocyte transendothelial migration_Homo sapiens_hsa046700.42808853
156Cardiac muscle contraction_Homo sapiens_hsa042600.42412812
157Sphingolipid metabolism_Homo sapiens_hsa006000.41440333

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