ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.28512941
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.65201857
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.50538690
4	ATP synthesis coupled proton transport (GO:0015986)	5.50538690
5	viral transcription (GO:0019083)	5.42406256
6	oxidative phosphorylation (GO:0006119)	5.32681457
7	translational termination (GO:0006415)	5.28963815
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.00995051
9	translational elongation (GO:0006414)	4.84248675
10	ribosomal small subunit biogenesis (GO:0042274)	4.81739276
11	DNA deamination (GO:0045006)	4.76831525
12	chaperone-mediated protein transport (GO:0072321)	4.62817164
13	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.61772197
14	protein targeting to ER (GO:0045047)	4.50134070
15	cotranslational protein targeting to membrane (GO:0006613)	4.45757710
16	respiratory electron transport chain (GO:0022904)	4.38018282
17	electron transport chain (GO:0022900)	4.26388152
18	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.26325719
19	protein localization to endoplasmic reticulum (GO:0070972)	4.22401003
20	viral life cycle (GO:0019058)	4.12143791
21	peptidyl-histidine modification (GO:0018202)	4.08819462
22	cellular protein complex disassembly (GO:0043624)	4.07378390
23	translational initiation (GO:0006413)	4.07296917
24	ribosomal large subunit biogenesis (GO:0042273)	3.98876328
25	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.94990982
26	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.90455537
27	maturation of SSU-rRNA (GO:0030490)	3.87022928
28	protein complex disassembly (GO:0043241)	3.50792077
29	translation (GO:0006412)	3.50664603
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.50007870
31	protein neddylation (GO:0045116)	3.47262280
32	galactose catabolic process (GO:0019388)	3.45426437
33	tricarboxylic acid cycle (GO:0006099)	3.44226609
34	hydrogen ion transmembrane transport (GO:1902600)	3.43867421
35	aldehyde catabolic process (GO:0046185)	3.41230929
36	macromolecular complex disassembly (GO:0032984)	3.32213405
37	DNA strand elongation involved in DNA replication (GO:0006271)	3.30241709
38	formation of translation preinitiation complex (GO:0001731)	3.29564078
39	ATP biosynthetic process (GO:0006754)	3.24803186
40	telomere maintenance via semi-conservative replication (GO:0032201)	3.22073606
41	ribonucleoprotein complex biogenesis (GO:0022613)	3.20194732
42	positive regulation of mitochondrial fission (GO:0090141)	3.19156647
43	protein targeting to mitochondrion (GO:0006626)	3.13672995
44	DNA strand elongation (GO:0022616)	3.12337191
45	termination of RNA polymerase III transcription (GO:0006386)	3.09453595
46	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.09453595
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.06536118
48	spliceosomal snRNP assembly (GO:0000387)	3.05631363
49	proton transport (GO:0015992)	3.05490643
50	intracellular protein transmembrane import (GO:0044743)	3.04072523
51	protein localization to mitochondrion (GO:0070585)	3.02010591
52	sarcomere organization (GO:0045214)	3.01113903
53	hydrogen transport (GO:0006818)	2.99328695
54	respiratory chain complex IV assembly (GO:0008535)	2.98323469
55	establishment of protein localization to mitochondrion (GO:0072655)	2.97808575
56	folic acid-containing compound biosynthetic process (GO:0009396)	2.97426895
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.97145428
58	nucleobase-containing small molecule interconversion (GO:0015949)	2.96554917
59	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.96479350
60	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.96479350
61	rRNA modification (GO:0000154)	2.93028061
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.92935202
63	protein targeting to membrane (GO:0006612)	2.92054735
64	regulation of mitochondrial translation (GO:0070129)	2.90809795
65	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.89381530
66	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO	2.88153473
67	actin-myosin filament sliding (GO:0033275)	2.87519178
68	muscle filament sliding (GO:0030049)	2.87519178
69	pteridine-containing compound biosynthetic process (GO:0042559)	2.84429882
70	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.82395586
71	cytochrome complex assembly (GO:0017004)	2.82242165
72	cellular component biogenesis (GO:0044085)	2.80339194
73	telomere maintenance via recombination (GO:0000722)	2.79047823
74	histone-serine phosphorylation (GO:0035404)	2.78371001
75	heart contraction (GO:0060047)	2.78078986
76	heart process (GO:0003015)	2.78078986
77	mitochondrial transport (GO:0006839)	2.77965272
78	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.77088191
79	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.76725656
80	aerobic respiration (GO:0009060)	2.76109772
81	AMP metabolic process (GO:0046033)	2.76065879
82	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.75708386
83	DNA damage response, detection of DNA damage (GO:0042769)	2.73086041
84	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	2.72423862
85	protein targeting (GO:0006605)	2.72088682
86	IMP biosynthetic process (GO:0006188)	2.71653758
87	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70926474
88	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.70857450
89	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.70857450
90	negative regulation of release of cytochrome c from mitochondria (GO:0090201)	2.70708621
91	nucleobase biosynthetic process (GO:0046112)	2.68674563
92	kinetochore organization (GO:0051383)	2.66623930
93	mRNA catabolic process (GO:0006402)	2.66335709
94	4-hydroxyproline metabolic process (GO:0019471)	2.65539596
95	inner mitochondrial membrane organization (GO:0007007)	2.64508873
96	regulation of cofactor metabolic process (GO:0051193)	2.63657989
97	regulation of coenzyme metabolic process (GO:0051196)	2.63657989
98	establishment of protein localization to membrane (GO:0090150)	2.63458378
99	DNA replication initiation (GO:0006270)	2.62945692
100	negative regulation of ligase activity (GO:0051352)	2.62661216
101	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.62661216
102	nucleoside monophosphate biosynthetic process (GO:0009124)	2.61282588
103	ribonucleoside monophosphate biosynthetic process (GO:0009156)	2.61207561
104	NADH dehydrogenase complex assembly (GO:0010257)	2.60512541
105	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.60512541
106	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.60512541
107	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.59669491
108	IMP metabolic process (GO:0046040)	2.59595268
109	RNA catabolic process (GO:0006401)	2.59245575
110	DNA unwinding involved in DNA replication (GO:0006268)	2.56969880
111	chromatin remodeling at centromere (GO:0031055)	2.56784615
112	protein-cofactor linkage (GO:0018065)	2.55780742
113	pentose-phosphate shunt (GO:0006098)	2.55481295
114	establishment of protein localization to organelle (GO:0072594)	2.54806816
115	establishment of viral latency (GO:0019043)	2.53857859
116	desmosome organization (GO:0002934)	2.53444892
117	7-methylguanosine mRNA capping (GO:0006370)	2.53335280
118	nucleoside salvage (GO:0043174)	2.52376761
119	CENP-A containing nucleosome assembly (GO:0034080)	2.51956698
120	cullin deneddylation (GO:0010388)	2.51596086
121	mitochondrial respiratory chain complex assembly (GO:0033108)	2.51379086
122	regulation of cellular amino acid metabolic process (GO:0006521)	2.50985719
123	purine nucleobase biosynthetic process (GO:0009113)	2.50046684
124	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	2.48978620
125	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	2.48978620
126	protein complex biogenesis (GO:0070271)	2.48825925
127	mitotic recombination (GO:0006312)	2.47303251
128	cellular respiration (GO:0045333)	2.44759223
129	telomere maintenance via telomere lengthening (GO:0010833)	2.43980065
130	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.43840253
131	rRNA metabolic process (GO:0016072)	2.42965387
132	ventricular cardiac muscle cell development (GO:0055015)	2.42514427
133	rRNA processing (GO:0006364)	2.42411387
134	proteasome assembly (GO:0043248)	2.41933328
135	nucleoside triphosphate biosynthetic process (GO:0009142)	2.41139916
136	pseudouridine synthesis (GO:0001522)	2.40637139
137	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.39715287
138	negative regulation of mitochondrion organization (GO:0010823)	2.39268616
139	T cell apoptotic process (GO:0070231)	2.36703177
140	purine ribonucleoside biosynthetic process (GO:0046129)	2.36220099
141	purine nucleoside biosynthetic process (GO:0042451)	2.36220099
142	ribosome biogenesis (GO:0042254)	2.35236015
143	establishment of integrated proviral latency (GO:0075713)	2.32232969
144	peptidyl-proline hydroxylation (GO:0019511)	2.30247214
145	nucleoside biosynthetic process (GO:0009163)	2.29378971

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	5.19679335
2	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	4.58269062
3	MYC_18555785_ChIP-Seq_MESCs_Mouse	4.37111834
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.71611236
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.57578808
6	TP63_17297297_ChIP-ChIP_HaCaT_Human	3.05412233
7	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.97774883
8	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.83392953
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.69619238
10	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.66328552
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.60028236
12	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.52096663
13	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.51692959
14	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.49089918
15	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.42421552
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.41481168
17	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.39254668
18	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.30294267
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	2.30050511
20	XRN2_22483619_ChIP-Seq_HELA_Human	2.29375051
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.23005401
22	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.19871214
23	NELFA_20434984_ChIP-Seq_ESCs_Mouse	2.12395575
24	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.10211339
25	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.08777016
26	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.06763394
27	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.03911691
28	DCP1A_22483619_ChIP-Seq_HELA_Human	1.91101803
29	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.85942916
30	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.82737234
31	VDR_22108803_ChIP-Seq_LS180_Human	1.81731672
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.80507623
33	AR_21909140_ChIP-Seq_LNCAP_Human	1.76758196
34	VDR_23849224_ChIP-Seq_CD4+_Human	1.76503917
35	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.72375328
36	FUS_26573619_Chip-Seq_HEK293_Human	1.71789587
37	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.69182174
38	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.67897123
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.67499053
40	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.66177958
41	ZFX_18555785_ChIP-Seq_MESCs_Mouse	1.65620762
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.64017563
43	EWS_26573619_Chip-Seq_HEK293_Human	1.60380261
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.59757627
45	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.59300141
46	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.58350481
47	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.58071054
48	ZNF274_21170338_ChIP-Seq_K562_Hela	1.57452068
49	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.55669898
50	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.52481805
51	FOXP3_21729870_ChIP-Seq_TREG_Human	1.51775672
52	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.51477204
53	IGF1R_20145208_ChIP-Seq_DFB_Human	1.50432346
54	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47762924
55	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.46312873
56	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.46195972
57	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.45681304
58	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.45048510
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.45022480
60	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.39574333
61	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.38808464
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.38596266
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.36476858
64	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.34462611
65	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.33811926
66	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	1.30290943
67	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.30267305
68	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.29851295
69	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.29740895
70	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.29182425
71	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.28249454
72	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.27623030
73	HIF1A_21447827_ChIP-Seq_MCF-7_Human	1.27592919
74	* ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.26706289
75	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.25857382
76	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.20745353
77	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.20645884
78	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.20369338
79	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.18769378
80	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.18598371
81	EGR1_19374776_ChIP-ChIP_THP-1_Human	1.17878207
82	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.17801462
83	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.17396918
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.17229459
85	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	1.16494826
86	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.14204268
87	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.13240524
88	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.12567882
89	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.11542378
90	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.11166393
91	TAF15_26573619_Chip-Seq_HEK293_Human	1.10329806
92	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.10268016
93	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.09476377
94	VDR_21846776_ChIP-Seq_THP-1_Human	1.09454994
95	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08868795
96	* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.07839156
97	ZNF263_19887448_ChIP-Seq_K562_Human	1.06787130
98	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.06404751
99	KLF4_18358816_ChIP-ChIP_MESCs_Mouse	1.06193261
100	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05730859
101	OCT4_18692474_ChIP-Seq_MEFs_Mouse	1.05235120
102	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.04701506
103	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04682105
104	P300_19829295_ChIP-Seq_ESCs_Human	1.03831061
105	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.03690454
106	CLOCK_20551151_ChIP-Seq_293T_Human	1.03531537
107	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.02632203
108	CNOT3_19339689_ChIP-ChIP_MESCs_Mouse	1.02351188
109	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.00866978
110	ATF3_27146783_Chip-Seq_COLON_Human	1.00489942
111	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.99805751
112	MYC_22102868_ChIP-Seq_BL_Human	0.99539705
113	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.97748481
114	MYC_18940864_ChIP-ChIP_HL60_Human	0.97099941
115	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	0.95725459
116	SOX17_20123909_ChIP-Seq_XEN_Mouse	0.95241182
117	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.94434886
118	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.94324369
119	KDM5A_27292631_Chip-Seq_BREAST_Human	0.93864254
120	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.93777934
121	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92671221
122	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.92178720
123	TP53_22573176_ChIP-Seq_HFKS_Human	0.90773790
124	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.90586707
125	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.90349697
126	CIITA_25753668_ChIP-Seq_RAJI_Human	0.89791116
127	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.88868989
128	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.88442746
129	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.86868404
130	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	0.84975673
131	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.84424144
132	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.84145957
133	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.80823335
134	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.80651941
135	AR_20517297_ChIP-Seq_VCAP_Human	0.79009961
136	HTT_18923047_ChIP-ChIP_STHdh_Human	0.78855136
137	NANOG_19829295_ChIP-Seq_ESCs_Human	0.78286611
138	SOX2_19829295_ChIP-Seq_ESCs_Human	0.78286611
139	ERG_20517297_ChIP-Seq_VCAP_Human	0.74380189
140	RNF2_27304074_Chip-Seq_NSC_Mouse	0.74121356
141	NANOG_18700969_ChIP-ChIP_MESCs_Mouse	0.73712302

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003806_abnormal_nucleotide_metabolis	3.46986343
2	MP0006292_abnormal_olfactory_placode	3.17742706
3	MP0003646_muscle_fatigue	3.01018016
4	MP0004084_abnormal_cardiac_muscle	2.98123225
5	MP0003136_yellow_coat_color	2.63569806
6	MP0006072_abnormal_retinal_apoptosis	2.54744603
7	MP0003880_abnormal_central_pattern	2.47911726
8	MP0002938_white_spotting	2.42529816
9	MP0003693_abnormal_embryo_hatching	2.42107115
10	MP0001529_abnormal_vocalization	2.41680853
11	MP0004957_abnormal_blastocyst_morpholog	2.37489550
12	MP0003705_abnormal_hypodermis_morpholog	2.36991431
13	MP0003122_maternal_imprinting	2.34980029
14	MP0003186_abnormal_redox_activity	2.09730825
15	MP0003567_abnormal_fetal_cardiomyocyte	2.06723981
16	MP0000749_muscle_degeneration	1.97740880
17	MP0009697_abnormal_copulation	1.95916101
18	MP0004043_abnormal_pH_regulation	1.95831828
19	MP0010030_abnormal_orbit_morphology	1.88502111
20	MP0006036_abnormal_mitochondrial_physio	1.85255583
21	MP0005330_cardiomyopathy	1.84587148
22	MP0008775_abnormal_heart_ventricle	1.82663906
23	MP0006054_spinal_hemorrhage	1.81572905
24	MP0008438_abnormal_cutaneous_collagen	1.76700671
25	MP0010352_gastrointestinal_tract_polyps	1.75034597
26	MP0010234_abnormal_vibrissa_follicle	1.74466379
27	MP0004215_abnormal_myocardial_fiber	1.74185545
28	MP0003011_delayed_dark_adaptation	1.71143601
29	MP0003123_paternal_imprinting	1.70067134
30	MP0001293_anophthalmia	1.63417817
31	MP0004145_abnormal_muscle_electrophysio	1.57814229
32	MP0001984_abnormal_olfaction	1.57106570
33	MP0003221_abnormal_cardiomyocyte_apopto	1.56570785
34	MP0005360_urolithiasis	1.56313318
35	MP0004036_abnormal_muscle_relaxation	1.54926915
36	MP0003718_maternal_effect	1.50724229
37	MP0003077_abnormal_cell_cycle	1.50062496
38	MP0002972_abnormal_cardiac_muscle	1.49887268
39	MP0000750_abnormal_muscle_regeneration	1.48761228
40	MP0009379_abnormal_foot_pigmentation	1.47451202
41	MP0008007_abnormal_cellular_replicative	1.47431758
42	MP0001544_abnormal_cardiovascular_syste	1.47177730
43	MP0005385_cardiovascular_system_phenoty	1.47177730
44	MP0000343_altered_response_to	1.47033916
45	MP0000566_synostosis	1.46484770
46	MP0010094_abnormal_chromosome_stability	1.45057361
47	MP0002090_abnormal_vision	1.43726095
48	MP0003121_genomic_imprinting	1.43055443
49	MP0000490_abnormal_crypts_of	1.42800659
50	MP0002822_catalepsy	1.41727794
51	MP0001485_abnormal_pinna_reflex	1.39792201
52	MP0008877_abnormal_DNA_methylation	1.39149385
53	MP0000537_abnormal_urethra_morphology	1.38216282
54	MP0005551_abnormal_eye_electrophysiolog	1.38044994
55	MP0000751_myopathy	1.36102683
56	MP0005499_abnormal_olfactory_system	1.34604805
57	MP0005394_taste/olfaction_phenotype	1.34604805
58	MP0008789_abnormal_olfactory_epithelium	1.34552626
59	MP0005275_abnormal_skin_tensile	1.33793631
60	MP0004142_abnormal_muscle_tone	1.33643761
61	MP0005253_abnormal_eye_physiology	1.33403634
62	MP0009053_abnormal_anal_canal	1.33365745
63	MP0004087_abnormal_muscle_fiber	1.31600993
64	MP0010630_abnormal_cardiac_muscle	1.30475464
65	MP0004484_altered_response_of	1.30431568
66	MP0005503_abnormal_tendon_morphology	1.29273136
67	MP0003937_abnormal_limbs/digits/tail_de	1.26429400
68	MP0002396_abnormal_hematopoietic_system	1.25831994
69	MP0002638_abnormal_pupillary_reflex	1.25654689
70	MP0005266_abnormal_metabolism	1.24485728
71	MP0008932_abnormal_embryonic_tissue	1.24439737
72	MP0005365_abnormal_bile_salt	1.24033005
73	MP0002132_abnormal_respiratory_system	1.22708899
74	MP0005023_abnormal_wound_healing	1.22303864
75	MP0003279_aneurysm	1.20974422
76	MP0005408_hypopigmentation	1.20275962
77	MP0005377_hearing/vestibular/ear_phenot	1.19507017
78	MP0003878_abnormal_ear_physiology	1.19507017
79	MP0003828_pulmonary_edema	1.18297701
80	MP0005085_abnormal_gallbladder_physiolo	1.17811860
81	MP0005332_abnormal_amino_acid	1.17800234
82	MP0001346_abnormal_lacrimal_gland	1.17539410
83	MP0003566_abnormal_cell_adhesion	1.15132312
84	MP0001764_abnormal_homeostasis	1.14796820
85	MP0003195_calcinosis	1.14769920
86	MP0005084_abnormal_gallbladder_morpholo	1.14149497
87	MP0002269_muscular_atrophy	1.13385862
88	MP0003111_abnormal_nucleus_morphology	1.13153406
89	MP0008995_early_reproductive_senescence	1.13011004
90	MP0003315_abnormal_perineum_morphology	1.11408692
91	MP0001286_abnormal_eye_development	1.09751738
92	MP0006138_congestive_heart_failure	1.08962036
93	MP0001730_embryonic_growth_arrest	1.08359410
94	MP0002139_abnormal_hepatobiliary_system	1.07167962
95	MP0000631_abnormal_neuroendocrine_gland	1.06701447
96	MP0002697_abnormal_eye_size	1.04417752
97	MP0008875_abnormal_xenobiotic_pharmacok	1.04162902
98	MP0004233_abnormal_muscle_weight	1.03911011
99	MP0002653_abnormal_ependyma_morphology	1.03094319
100	MP0009384_cardiac_valve_regurgitation	1.02482237
101	MP0002233_abnormal_nose_morphology	1.01779322
102	MP0002736_abnormal_nociception_after	1.00714327
103	MP0002282_abnormal_trachea_morphology	1.00194959
104	MP0006035_abnormal_mitochondrial_morpho	0.99563678
105	MP0004133_heterotaxia	0.99062647
106	MP0003941_abnormal_skin_development	0.97781350
107	MP0003938_abnormal_ear_development	0.96418605
108	MP0002837_dystrophic_cardiac_calcinosis	0.96387941
109	MP0000778_abnormal_nervous_system	0.94940982
110	MP0009046_muscle_twitch	0.94883333
111	MP0002160_abnormal_reproductive_system	0.93945701
112	MP0005319_abnormal_enzyme/_coenzyme	0.93746056
113	MP0003283_abnormal_digestive_organ	0.92211605
114	MP0004130_abnormal_muscle_cell	0.91708836
115	MP0005620_abnormal_muscle_contractility	0.91629456
116	MP0000350_abnormal_cell_proliferation	0.91194223
117	MP0000372_irregular_coat_pigmentation	0.91038369
118	MP0005451_abnormal_body_composition	0.90914324
119	MP0000647_abnormal_sebaceous_gland	0.90833469
120	MP0008872_abnormal_physiological_respon	0.90789003
121	MP0002106_abnormal_muscle_physiology	0.90075933
122	MP0002163_abnormal_gland_morphology	0.88797889
123	MP0008058_abnormal_DNA_repair	0.88351476
124	MP0006276_abnormal_autonomic_nervous	0.87404216
125	MP0001853_heart_inflammation	0.86638659
126	MP0002557_abnormal_social/conspecific_i	0.85523128
127	MP0004019_abnormal_vitamin_homeostasis	0.85350775
128	MP0002272_abnormal_nervous_system	0.84854405
129	MP0009333_abnormal_splenocyte_physiolog	0.84768520
130	MP0003137_abnormal_impulse_conducting	0.84582116
131	MP0002060_abnormal_skin_morphology	0.84244022
132	MP0002210_abnormal_sex_determination	0.84216407
133	MP0000026_abnormal_inner_ear	0.83915208
134	MP0001697_abnormal_embryo_size	0.83551157
135	MP0004147_increased_porphyrin_level	0.83515774
136	MP0003984_embryonic_growth_retardation	0.83182370
137	MP0000477_abnormal_intestine_morphology	0.82754088
138	MP0002234_abnormal_pharynx_morphology	0.82524006
139	MP0002088_abnormal_embryonic_growth/wei	0.82375538
140	MP0003890_abnormal_embryonic-extraembry	0.82106275
141	MP0000049_abnormal_middle_ear	0.81140457
142	MP0005195_abnormal_posterior_eye	0.80894563
143	MP0010155_abnormal_intestine_physiology	0.80600178
144	MP0004272_abnormal_basement_membrane	0.80276891
145	MP0005391_vision/eye_phenotype	0.79850750
146	MP0005636_abnormal_mineral_homeostasis	0.79809077
147	MP0002102_abnormal_ear_morphology	0.79421820
148	MP0002332_abnormal_exercise_endurance	0.79242368
149	MP0000858_altered_metastatic_potential	0.78980132
150	MP0002277_abnormal_respiratory_mucosa	0.78463769
151	MP0004197_abnormal_fetal_growth/weight/	0.78306692
152	MP0005397_hematopoietic_system_phenotyp	0.77601595
153	MP0001545_abnormal_hematopoietic_system	0.77601595
154	MP0004808_abnormal_hematopoietic_stem	0.77202905
155	MP0000653_abnormal_sex_gland	0.76086797
156	MP0002080_prenatal_lethality	0.75281988
157	MP0000759_abnormal_skeletal_muscle	0.75036482
158	MP0003786_premature_aging	0.74573155
159	MP0001145_abnormal_male_reproductive	0.73312959
160	MP0001672_abnormal_embryogenesis/_devel	0.72678487
161	MP0005380_embryogenesis_phenotype	0.72678487
162	MP0005187_abnormal_penis_morphology	0.72570488
163	MP0009785_altered_susceptibility_to	0.71693613
164	MP0000579_abnormal_nail_morphology	0.71302996
165	MP0000358_abnormal_cell_content/	0.70858405
166	MP0002751_abnormal_autonomic_nervous	0.70319969
167	MP0002752_abnormal_somatic_nervous	0.69390407
168	MP0005670_abnormal_white_adipose	0.68968818
169	MP0000762_abnormal_tongue_morphology	0.68708991
170	MP0002019_abnormal_tumor_incidence	0.68520110
171	MP0000313_abnormal_cell_death	0.67530688
172	MP0005165_increased_susceptibility_to	0.67459240

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	4.60342240
2	Abnormal mitochondria in muscle tissue (HP:0008316)	4.54767104
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.21548408
4	Abnormal number of erythroid precursors (HP:0012131)	4.03700002
5	Acute encephalopathy (HP:0006846)	4.00659548
6	Exercise-induced muscle cramps (HP:0003710)	3.96962338
7	Hepatic necrosis (HP:0002605)	3.81951845
8	Rhabdomyolysis (HP:0003201)	3.79052508
9	Mitochondrial inheritance (HP:0001427)	3.76596680
10	Progressive macrocephaly (HP:0004481)	3.62269468
11	Increased CSF lactate (HP:0002490)	3.61545941
12	Myoglobinuria (HP:0002913)	3.58991291
13	Reticulocytopenia (HP:0001896)	3.54424616
14	Hepatocellular necrosis (HP:0001404)	3.43070820
15	Cerebral edema (HP:0002181)	3.37877954
16	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.35402155
17	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.35402155
18	Exercise intolerance (HP:0003546)	3.31653992
19	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.30584470
20	Hyperglycinemia (HP:0002154)	3.25667599
21	Abnormality of glycolysis (HP:0004366)	3.12674106
22	Increased serum pyruvate (HP:0003542)	3.12674106
23	Increased muscle lipid content (HP:0009058)	3.03766321
24	Ventricular tachycardia (HP:0004756)	3.02081430
25	Increased intramyocellular lipid droplets (HP:0012240)	2.99328002
26	Lipid accumulation in hepatocytes (HP:0006561)	2.93997626
27	Conjunctival hamartoma (HP:0100780)	2.87228719
28	Lactic acidosis (HP:0003128)	2.85323066
29	Right ventricular cardiomyopathy (HP:0011663)	2.83121403
30	Dicarboxylic aciduria (HP:0003215)	2.81869918
31	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.81869918
32	Palpitations (HP:0001962)	2.79498284
33	Hypoglycemic coma (HP:0001325)	2.78428913
34	Increased hepatocellular lipid droplets (HP:0006565)	2.77577886
35	Lipoatrophy (HP:0100578)	2.77296833
36	Respiratory failure (HP:0002878)	2.76027653
37	Multiple enchondromatosis (HP:0005701)	2.74467895
38	Increased serum lactate (HP:0002151)	2.73698283
39	Ragged-red muscle fibers (HP:0003200)	2.66799103
40	Nausea (HP:0002018)	2.65633805
41	Medial flaring of the eyebrow (HP:0010747)	2.63387203
42	Hyperglycinuria (HP:0003108)	2.56296316
43	Oral leukoplakia (HP:0002745)	2.46185607
44	Macrocytic anemia (HP:0001972)	2.44392124
45	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.43510542
46	Protrusio acetabuli (HP:0003179)	2.42495031
47	Pancreatic cysts (HP:0001737)	2.38528959
48	Pallor (HP:0000980)	2.37011808
49	Abnormality of serine family amino acid metabolism (HP:0010894)	2.36182304
50	Abnormality of glycine metabolism (HP:0010895)	2.36182304
51	Pancreatic fibrosis (HP:0100732)	2.34173896
52	Abnormality of serum amino acid levels (HP:0003112)	2.32257678
53	Abnormal cartilage morphology (HP:0002763)	2.31977855
54	Congenital primary aphakia (HP:0007707)	2.29678214
55	X-linked dominant inheritance (HP:0001423)	2.28943172
56	Type I transferrin isoform profile (HP:0003642)	2.28448760
57	Sudden death (HP:0001699)	2.27631068
58	Gait imbalance (HP:0002141)	2.25777508
59	Cupped ribs (HP:0000887)	2.24343472
60	Abnormality of fatty-acid metabolism (HP:0004359)	2.24231532
61	Septo-optic dysplasia (HP:0100842)	2.24003199
62	Cholecystitis (HP:0001082)	2.22720854
63	Abnormal gallbladder physiology (HP:0012438)	2.22720854
64	Abnormality of the 1st metacarpal (HP:0010009)	2.18919938
65	True hermaphroditism (HP:0010459)	2.18549314
66	Generalized aminoaciduria (HP:0002909)	2.16574195
67	Abnormality of reticulocytes (HP:0004312)	2.15356165
68	Abnormality of methionine metabolism (HP:0010901)	2.14566299
69	Flat acetabular roof (HP:0003180)	2.14380675
70	Dilated cardiomyopathy (HP:0001644)	2.14221902
71	Abnormal tarsal ossification (HP:0008369)	2.13620004
72	Neoplasm of the adrenal gland (HP:0100631)	2.12453692
73	Abnormality of the anterior horn cell (HP:0006802)	2.12418616
74	Degeneration of anterior horn cells (HP:0002398)	2.12418616
75	Nephrogenic diabetes insipidus (HP:0009806)	2.10369265
76	Methylmalonic acidemia (HP:0002912)	2.09518192
77	Irregular epiphyses (HP:0010582)	2.08110052
78	Methylmalonic aciduria (HP:0012120)	2.06755363
79	Abnormality of renal resorption (HP:0011038)	2.06510360
80	Colon cancer (HP:0003003)	2.06075438
81	Lethargy (HP:0001254)	2.04060221
82	Myokymia (HP:0002411)	2.03797172
83	Aplastic anemia (HP:0001915)	2.00546470
84	Exertional dyspnea (HP:0002875)	1.98881828
85	Abnormality of midbrain morphology (HP:0002418)	1.97640174
86	Molar tooth sign on MRI (HP:0002419)	1.97640174
87	Hyperinsulinemic hypoglycemia (HP:0000825)	1.96816901
88	Hyperphosphaturia (HP:0003109)	1.96664302
89	Microretrognathia (HP:0000308)	1.96510511
90	Optic disc pallor (HP:0000543)	1.94536097
91	Respiratory difficulties (HP:0002880)	1.93424384
92	Reduced antithrombin III activity (HP:0001976)	1.93393318
93	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.93174356
94	Hyperammonemia (HP:0001987)	1.92184384
95	Abnormality of carpal bone ossification (HP:0006257)	1.92052754
96	Muscle stiffness (HP:0003552)	1.91196800
97	Trismus (HP:0000211)	1.90620212
98	Congenital, generalized hypertrichosis (HP:0004540)	1.87807012
99	Vaginal atresia (HP:0000148)	1.87745298
100	Abnormality of the labia minora (HP:0012880)	1.85736187
101	Meckel diverticulum (HP:0002245)	1.85496832
102	Neoplasm of head and neck (HP:0012288)	1.84216421
103	Esophageal neoplasm (HP:0100751)	1.84216421
104	Genital tract atresia (HP:0001827)	1.83564517
105	Abnormality of the ileum (HP:0001549)	1.82740589
106	Supernumerary spleens (HP:0009799)	1.76454098
107	Type 1 muscle fiber predominance (HP:0003803)	1.74667582
108	Beaking of vertebral bodies (HP:0004568)	1.73183127
109	Breech presentation (HP:0001623)	1.72433491
110	Partial duplication of thumb phalanx (HP:0009944)	1.72239598
111	Blindness (HP:0000618)	1.72103485
112	Leukodystrophy (HP:0002415)	1.70913771
113	Supraventricular tachycardia (HP:0004755)	1.70628851
114	Thrombocytosis (HP:0001894)	1.70356653
115	Triphalangeal thumb (HP:0001199)	1.68979782
116	Stenosis of the external auditory canal (HP:0000402)	1.68646644
117	Atrial fibrillation (HP:0005110)	1.68511466
118	Adenoma sebaceum (HP:0009720)	1.68472919
119	Angiofibromas (HP:0010615)	1.68472919
120	Abnormal biliary tract physiology (HP:0012439)	1.67512341
121	Bile duct proliferation (HP:0001408)	1.67512341
122	Supraventricular arrhythmia (HP:0005115)	1.66807304
123	Glycosuria (HP:0003076)	1.66041967
124	Abnormality of urine glucose concentration (HP:0011016)	1.66041967
125	Neonatal short-limb short stature (HP:0008921)	1.65422445
126	Renal cortical cysts (HP:0000803)	1.63788850
127	3-Methylglutaconic aciduria (HP:0003535)	1.62817231
128	Gliosis (HP:0002171)	1.62546862
129	Gout (HP:0001997)	1.62216997
130	Absent septum pellucidum (HP:0001331)	1.61013867
131	Vomiting (HP:0002013)	1.60947106
132	Renal tubular dysfunction (HP:0000124)	1.60791204
133	Abnormality of the 2nd finger (HP:0004100)	1.60615516
134	Sclerocornea (HP:0000647)	1.59154336
135	Renal Fanconi syndrome (HP:0001994)	1.59146358
136	Abnormality of the left ventricular outflow tract (HP:0011103)	1.59011840
137	Subaortic stenosis (HP:0001682)	1.59011840
138	Neoplasm of the rectum (HP:0100743)	1.58635875
139	CNS demyelination (HP:0007305)	1.57494798
140	Primary atrial arrhythmia (HP:0001692)	1.55245690
141	Sparse eyelashes (HP:0000653)	1.54480325
142	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.54191054
143	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.53856945
144	Abnormality of the calf musculature (HP:0001430)	1.53794601
145	Abnormality of alanine metabolism (HP:0010916)	1.52212946
146	Hyperalaninemia (HP:0003348)	1.52212946
147	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.52212946
148	Emotional lability (HP:0000712)	1.51802464

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	4.53488059
2	VRK2	4.15405065
3	PKN2	3.42779568
4	TESK1	2.51313973
5	EIF2AK1	2.40192422
6	FLT3	2.37713045
7	MYLK	2.33940828
8	NEK1	2.32856896
9	TNIK	2.30881654
10	BCKDK	2.28980271
11	MST1R	2.28816127
12	PIK3CA	2.16788403
13	OBSCN	2.12108405
14	WEE1	2.12037540
15	PIM2	2.01140146
16	BUB1	1.97687320
17	CDK19	1.96093307
18	MST4	1.95780642
19	CCNB1	1.95406867
20	PDK2	1.94308699
21	WNK3	1.91815280
22	LIMK1	1.88870667
23	TESK2	1.85541483
24	BMPR1B	1.82470872
25	MAP4K2	1.80778101
26	KDR	1.77902502
27	TAF1	1.72775601
28	PLK3	1.65002203
29	TTN	1.60162436
30	SCYL2	1.55216185
31	RPS6KB2	1.49420100
32	RPS6KA4	1.48258943
33	MAP3K11	1.47784599
34	WNK4	1.47125694
35	ERN1	1.46254378
36	CASK	1.46071201
37	TRIB3	1.44940910
38	NUAK1	1.41647712
39	STK16	1.40771497
40	EPHA4	1.40659000
41	BRSK2	1.38506883
42	TAOK2	1.38436849
43	DYRK2	1.35893123
44	NME1	1.35075550
45	CDC7	1.34284015
46	ILK	1.33666038
47	MAP3K12	1.30658271
48	STK24	1.28406455
49	ZAK	1.27671586
50	LRRK2	1.26915911
51	STK39	1.24573572
52	PBK	1.17698541
53	TRIM28	1.16147345
54	TGFBR1	1.14498393
55	MAP3K3	1.13500531
56	AURKB	1.13296038
57	EIF2AK3	1.12683452
58	MAP2K3	1.12181085
59	NEK2	1.08478675
60	PAK4	1.08357643
61	BCR	1.07881920
62	TLK1	1.06819506
63	ACVR1B	1.06761736
64	VRK1	1.06089013
65	GRK1	1.05690945
66	MAP3K8	1.01105576
67	NEK9	0.99745734
68	EPHB2	0.99131125
69	MAPKAPK3	0.96081153
70	MAP3K4	0.94737948
71	CDK7	0.92811529
72	CSNK1G2	0.92500353
73	TEC	0.90200127
74	LATS2	0.90043561
75	DAPK3	0.89214573
76	TTK	0.88391945
77	PINK1	0.87652426
78	INSRR	0.86830402
79	PLK4	0.86625125
80	PDK4	0.86093193
81	PDK3	0.86093193
82	ARAF	0.86091885
83	STK38L	0.86026093
84	ERBB3	0.85527529
85	PLK1	0.84780480
86	MAP3K7	0.83083998
87	OXSR1	0.83028943
88	MKNK2	0.82033240
89	PRKG2	0.81736857
90	CSNK1G3	0.79658370
91	PHKG1	0.78754986
92	PHKG2	0.78754986
93	PLK2	0.76450527
94	FGFR2	0.74677803
95	CSNK2A2	0.74392201
96	PRKCG	0.73045372
97	PAK1	0.72978473
98	CSNK1G1	0.72831765
99	CDK8	0.72442372
100	MET	0.72227070
101	CDK4	0.72157228
102	LMTK2	0.72093537
103	MOS	0.71919713
104	ABL2	0.69708391
105	STK10	0.66258756
106	SRPK1	0.64566604
107	BRAF	0.63558029
108	MAP3K10	0.60535194
109	MAP2K2	0.58567913
110	AURKA	0.58485593
111	STK4	0.57611099
112	ATR	0.57575098
113	PIM1	0.57474993
114	STK3	0.56602127
115	AKT2	0.56114568
116	TYK2	0.56057501
117	MAP3K5	0.55981630
118	PNCK	0.55701937
119	MAP2K7	0.55634827
120	BLK	0.55336411
121	TSSK6	0.55295509
122	CSNK1A1L	0.54549627
123	DYRK3	0.54023208
124	BRSK1	0.53931750
125	PIK3CG	0.52874074
126	EPHA2	0.52209756
127	PAK3	0.52038239
128	EEF2K	0.51110740
129	PRKCE	0.50758454
130	MKNK1	0.50415827
131	CSNK1E	0.49873680
132	CHEK2	0.48405789
133	PASK	0.48363548
134	PAK2	0.48213729
135	RAF1	0.48098459
136	CSNK2A1	0.47967463
137	RPS6KA5	0.45178462
138	FGFR1	0.44698112
139	MARK3	0.43760457
140	MAP2K6	0.43449430
141	RIPK1	0.42655603
142	MAPK11	0.41737166
143	CSNK1A1	0.41619804
144	CAMKK2	0.41537114
145	EIF2AK2	0.41523118
146	MUSK	0.41443419
147	NTRK2	0.41371739
148	ADRBK2	0.40246440
149	FRK	0.39398955
150	MAPKAPK5	0.39089145
151	NLK	0.38990247
152	MARK1	0.36733191
153	MAPK13	0.34091585
154	ATM	0.31809551
155	CDK11A	0.31414443
156	PRKACA	0.30384085

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.11447701
2	Parkinsons disease_Homo sapiens_hsa05012	3.22345504
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.17760842
4	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.04640377
5	DNA replication_Homo sapiens_hsa03030	2.99489779
6	Proteasome_Homo sapiens_hsa03050	2.50181807
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.29974328
8	Huntingtons disease_Homo sapiens_hsa05016	2.27745635
9	Mismatch repair_Homo sapiens_hsa03430	2.20082651
10	Carbon metabolism_Homo sapiens_hsa01200	2.15167984
11	Alzheimers disease_Homo sapiens_hsa05010	2.09613624
12	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.02112456
13	Sulfur metabolism_Homo sapiens_hsa00920	2.01446410
14	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.93561121
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.90891059
16	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.80042052
17	RNA polymerase_Homo sapiens_hsa03020	1.78864262
18	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.76388156
19	Pyrimidine metabolism_Homo sapiens_hsa00240	1.75777782
20	One carbon pool by folate_Homo sapiens_hsa00670	1.73558149
21	Base excision repair_Homo sapiens_hsa03410	1.66531061
22	Propanoate metabolism_Homo sapiens_hsa00640	1.57326950
23	Homologous recombination_Homo sapiens_hsa03440	1.50835658
24	Spliceosome_Homo sapiens_hsa03040	1.47524614
25	Pentose phosphate pathway_Homo sapiens_hsa00030	1.46789359
26	Nucleotide excision repair_Homo sapiens_hsa03420	1.44516948
27	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.43553370
28	Galactose metabolism_Homo sapiens_hsa00052	1.41440529
29	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.40659983
30	Sulfur relay system_Homo sapiens_hsa04122	1.35132109
31	Fatty acid degradation_Homo sapiens_hsa00071	1.34966428
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34747991
33	Pyruvate metabolism_Homo sapiens_hsa00620	1.34664606
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.33875382
35	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.31592382
36	Fatty acid elongation_Homo sapiens_hsa00062	1.27705450
37	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24229968
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.22705168
39	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.19972904
40	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.19515147
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.19396976
42	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.18496895
43	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.10990249
44	RNA transport_Homo sapiens_hsa03013	1.10281632
45	Folate biosynthesis_Homo sapiens_hsa00790	1.08021322
46	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.06082617
47	Nitrogen metabolism_Homo sapiens_hsa00910	1.02789128
48	Steroid biosynthesis_Homo sapiens_hsa00100	1.02775923
49	Glutathione metabolism_Homo sapiens_hsa00480	1.00589662
50	Selenocompound metabolism_Homo sapiens_hsa00450	0.97385394
51	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.97304911
52	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.96364516
53	Cell cycle_Homo sapiens_hsa04110	0.94564452
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.93158265
55	p53 signaling pathway_Homo sapiens_hsa04115	0.92154845
56	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.92126811
57	Legionellosis_Homo sapiens_hsa05134	0.88944349
58	RNA degradation_Homo sapiens_hsa03018	0.85632455
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85629305
60	Phenylalanine metabolism_Homo sapiens_hsa00360	0.83154453
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.81300483
62	Protein export_Homo sapiens_hsa03060	0.81268895
63	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.79047026
64	Purine metabolism_Homo sapiens_hsa00230	0.78305483
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.77742968
66	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.74739091
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73146318
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.72390151
69	Peroxisome_Homo sapiens_hsa04146	0.71958534
70	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.71823412
71	Metabolic pathways_Homo sapiens_hsa01100	0.70839281
72	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.70395612
73	Fat digestion and absorption_Homo sapiens_hsa04975	0.69667933
74	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.67323169
75	Linoleic acid metabolism_Homo sapiens_hsa00591	0.66938990
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.65463424
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.65462861
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.65194022
79	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.64293572
80	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.63104286
81	Fatty acid metabolism_Homo sapiens_hsa01212	0.61653126
82	Tyrosine metabolism_Homo sapiens_hsa00350	0.61650931
83	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.60576483
84	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.59580907
85	Non-homologous end-joining_Homo sapiens_hsa03450	0.58978257
86	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.57216657
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.53528851
88	Arginine and proline metabolism_Homo sapiens_hsa00330	0.53478928
89	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.52303235
90	Thyroid cancer_Homo sapiens_hsa05216	0.52171464
91	Caffeine metabolism_Homo sapiens_hsa00232	0.50885120
92	Mineral absorption_Homo sapiens_hsa04978	0.50338356
93	PPAR signaling pathway_Homo sapiens_hsa03320	0.50197431
94	Phototransduction_Homo sapiens_hsa04744	0.49213177
95	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.47765370
96	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.45939097
97	Tryptophan metabolism_Homo sapiens_hsa00380	0.44400499
98	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.43117816
99	Retinol metabolism_Homo sapiens_hsa00830	0.41345848
100	Bladder cancer_Homo sapiens_hsa05219	0.41006335
101	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.37292748
102	Nicotine addiction_Homo sapiens_hsa05033	0.35212308
103	Antigen processing and presentation_Homo sapiens_hsa04612	0.35198101
104	beta-Alanine metabolism_Homo sapiens_hsa00410	0.34922799
105	Arginine biosynthesis_Homo sapiens_hsa00220	0.34789713
106	Fanconi anemia pathway_Homo sapiens_hsa03460	0.33575758
107	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.29950866
108	Butanoate metabolism_Homo sapiens_hsa00650	0.29941523
109	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.29232673
110	mRNA surveillance pathway_Homo sapiens_hsa03015	0.28959903
111	Oocyte meiosis_Homo sapiens_hsa04114	0.28764564
112	Viral myocarditis_Homo sapiens_hsa05416	0.28279422
113	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.27410029
114	Basal transcription factors_Homo sapiens_hsa03022	0.26881498
115	Regulation of autophagy_Homo sapiens_hsa04140	0.26811615
116	Circadian rhythm_Homo sapiens_hsa04710	0.26593700
117	Small cell lung cancer_Homo sapiens_hsa05222	0.24677796
118	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.22631608
119	Herpes simplex infection_Homo sapiens_hsa05168	0.21678705
120	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.21572013
121	Apoptosis_Homo sapiens_hsa04210	0.21529293

FAM162A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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