FAM162B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to parathyroid hormone (GO:0071107)9.22183296
2positive regulation of hair cycle (GO:0042635)8.70133458
3positive regulation of hair follicle development (GO:0051798)8.70133458
4gonadal mesoderm development (GO:0007506)7.89878843
5positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)7.74644589
6positive regulation of cell cycle G2/M phase transition (GO:1902751)7.74644589
7synapsis (GO:0007129)7.67971760
8positive regulation of meiosis (GO:0045836)7.32558345
9glycine transport (GO:0015816)7.30164081
10positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)7.23974884
11positive regulation of meiotic cell cycle (GO:0051446)6.81706157
12male meiosis I (GO:0007141)6.81499615
13positive regulation of DNA-templated transcription, initiation (GO:2000144)6.63765248
14glomerulus development (GO:0032835)6.38023123
15response to water (GO:0009415)6.37986698
16detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)6.37220213
17hematopoietic stem cell proliferation (GO:0071425)6.27439041
18positive regulation of fibroblast migration (GO:0010763)6.25079541
19regulation of hair follicle development (GO:0051797)6.03972573
20NAD biosynthetic process (GO:0009435)6.02445021
21male meiosis (GO:0007140)5.94846417
22respiratory tube development (GO:0030323)5.82640617
23negative regulation of meiosis (GO:0045835)5.73774609
24L-amino acid import (GO:0043092)5.56411390
25centriole assembly (GO:0098534)5.50691137
26meiosis I (GO:0007127)5.44612021
27chromosome organization involved in meiosis (GO:0070192)5.41718648
28detection of calcium ion (GO:0005513)5.41087741
29regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)5.39581281
30exogenous drug catabolic process (GO:0042738)5.33121477
31inner ear receptor cell development (GO:0060119)5.29485404
32lung vasculature development (GO:0060426)5.17299483
33oogenesis (GO:0048477)4.95001844
34reflex (GO:0060004)4.92393733
35nicotinamide nucleotide biosynthetic process (GO:0019359)4.87792929
36pyridine nucleotide biosynthetic process (GO:0019363)4.87792929
37ribosomal small subunit assembly (GO:0000028)4.72511847
38resolution of meiotic recombination intermediates (GO:0000712)4.71441537
39regulation of DNA-templated transcription, initiation (GO:2000142)4.68146931
40myoblast differentiation (GO:0045445)4.67486057
41meiotic nuclear division (GO:0007126)4.63021027
42meiotic chromosome segregation (GO:0045132)4.50678281
43mitotic sister chromatid cohesion (GO:0007064)4.46635382
44regulation of meiosis (GO:0040020)4.41386631
45synaptonemal complex assembly (GO:0007130)4.39427304
46drug catabolic process (GO:0042737)4.38216504
47negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)4.32291360
48negative regulation of telomere maintenance (GO:0032205)4.30582213
49regulation of nuclear cell cycle DNA replication (GO:0033262)4.30334577
50response to hepatocyte growth factor (GO:0035728)4.30276801
51cellular response to hepatocyte growth factor stimulus (GO:0035729)4.30276801
52superoxide anion generation (GO:0042554)4.28474291
53endothelium development (GO:0003158)4.26735759
54negative regulation of androgen receptor signaling pathway (GO:0060766)4.23596289
55skeletal muscle fiber development (GO:0048741)4.23380918
56amino acid import (GO:0043090)4.22090800
57mesenchymal cell differentiation involved in kidney development (GO:0072161)4.16489861
58mesenchymal cell differentiation involved in renal system development (GO:2001012)4.16489861
59cellular response to vitamin D (GO:0071305)4.11946155
60proteasome assembly (GO:0043248)4.11780991
61midgut development (GO:0007494)4.11055651
62synaptonemal complex organization (GO:0070193)4.05258644
63DNA methylation involved in gamete generation (GO:0043046)4.04760786
64phosphorelay signal transduction system (GO:0000160)4.01068253
65detection of mechanical stimulus involved in sensory perception (GO:0050974)3.99431066
66regulation of meiotic cell cycle (GO:0051445)3.96974088
67regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.95077179
68sister chromatid cohesion (GO:0007062)3.92585472
69myotube cell development (GO:0014904)3.91280489
70negative regulation of myoblast differentiation (GO:0045662)3.90290573
71DNA synthesis involved in DNA repair (GO:0000731)3.90191788
72germ cell migration (GO:0008354)3.88320860
73meiotic cell cycle process (GO:1903046)3.88283962
74positive regulation of male gonad development (GO:2000020)3.87424022
75mesenchymal cell development (GO:0014031)3.85595005
76trabecula formation (GO:0060343)3.79946641
77pyridine-containing compound biosynthetic process (GO:0072525)3.78958988
78female gamete generation (GO:0007292)3.75195359
79gene silencing by RNA (GO:0031047)3.74820228
80regulation of hair cycle (GO:0042634)3.71078684
81labyrinthine layer development (GO:0060711)3.70999098
82lung-associated mesenchyme development (GO:0060484)3.70302875
83kinetochore assembly (GO:0051382)3.66092668
84neural crest cell development (GO:0014032)3.64321847
85piRNA metabolic process (GO:0034587)3.64050849
86regulation of RIG-I signaling pathway (GO:0039535)3.58027877
87regulation of G2/M transition of mitotic cell cycle (GO:0010389)3.57874943
88embryonic foregut morphogenesis (GO:0048617)3.57828176
89negative regulation of meiotic cell cycle (GO:0051447)3.57725599
90sex differentiation (GO:0007548)3.55779226
91regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.54684026
92negative regulation of protein localization to cell surface (GO:2000009)3.53252987
93positive regulation of DNA-dependent DNA replication (GO:2000105)3.52789137
94regulation of non-canonical Wnt signaling pathway (GO:2000050)3.50926512
95detection of mechanical stimulus (GO:0050982)3.49448972
96mitotic chromosome condensation (GO:0007076)3.46692598
97somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46644420
98somatic hypermutation of immunoglobulin genes (GO:0016446)3.46644420
99kinetochore organization (GO:0051383)3.46455282
100neurotransmitter biosynthetic process (GO:0042136)3.45932289
101lung morphogenesis (GO:0060425)3.43164015
102positive regulation of catenin import into nucleus (GO:0035413)3.40689148
103exocrine pancreas development (GO:0031017)3.38368704
104diacylglycerol metabolic process (GO:0046339)3.36792237
105positive regulation of calcium ion import (GO:0090280)3.36559317
106positive regulation of smooth muscle cell migration (GO:0014911)3.35788059
107RNA-dependent DNA replication (GO:0006278)3.33926759
108cell differentiation involved in metanephros development (GO:0072202)3.31538638
109cell migration involved in gastrulation (GO:0042074)3.31034670
110regulation of cell cycle G2/M phase transition (GO:1902749)3.30596619
111ribosomal small subunit biogenesis (GO:0042274)3.30368864
112response to gravity (GO:0009629)3.30122765
113formation of translation preinitiation complex (GO:0001731)3.27390958
114chromatin remodeling at centromere (GO:0031055)3.22249086
115enteric nervous system development (GO:0048484)3.21522534
116regulation of male gonad development (GO:2000018)3.20771717
117skeletal muscle contraction (GO:0003009)3.20396404
118regulation of smooth muscle cell differentiation (GO:0051150)3.18976008
119mitotic metaphase plate congression (GO:0007080)3.17750513
120meiotic cell cycle (GO:0051321)3.16845689
121stem cell development (GO:0048864)3.16358560
122lymphangiogenesis (GO:0001946)3.15413948
123protein K6-linked ubiquitination (GO:0085020)3.14876365
124CENP-A containing nucleosome assembly (GO:0034080)3.13631361
125positive regulation of cAMP-mediated signaling (GO:0043950)3.13331365
126negative regulation of signal transduction by p53 class mediator (GO:1901797)3.10840221
127multicellular organism reproduction (GO:0032504)3.10661571
128ncRNA 3-end processing (GO:0043628)3.08346484
129vitamin A metabolic process (GO:0006776)3.06482290
130SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)3.03584085
131negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.01401365
132DNA integration (GO:0015074)3.01007071
133establishment of protein localization to mitochondrial membrane (GO:0090151)3.00773161
134photoreceptor cell differentiation (GO:0046530)3.00719358
135eye photoreceptor cell differentiation (GO:0001754)3.00719358
136RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00278807
137tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00278807
138response to lipoprotein particle (GO:0055094)3.00234813
139cell migration involved in heart development (GO:0060973)2.99493643
140mesenchyme development (GO:0060485)2.97742921
141regulation of cardioblast differentiation (GO:0051890)2.97274295
142endocardial cushion morphogenesis (GO:0003203)2.96049594
143left/right axis specification (GO:0070986)2.95603537
144telomere maintenance via telomerase (GO:0007004)2.94202895
145DNA replication checkpoint (GO:0000076)2.93826341
146metaphase plate congression (GO:0051310)2.92291275
147cAMP catabolic process (GO:0006198)2.91651219
148paraxial mesoderm development (GO:0048339)2.90885362
149outer ear morphogenesis (GO:0042473)2.89259709
150spindle assembly involved in mitosis (GO:0090307)2.88553233
151epithelial cell maturation (GO:0002070)2.88197856
152exploration behavior (GO:0035640)2.87511058
153regulation of DNA endoreduplication (GO:0032875)2.86866460
154sensory perception of taste (GO:0050909)2.85355743
155protein maturation by protein folding (GO:0022417)2.84887063
156positive regulation of epidermis development (GO:0045684)2.84862061
157cyclic nucleotide catabolic process (GO:0009214)2.84581213
158regulation of secondary heart field cardioblast proliferation (GO:0003266)2.83435666
159regulation of cardioblast proliferation (GO:0003264)2.83435666
160regulation of gene silencing by RNA (GO:0060966)2.82468299
161regulation of posttranscriptional gene silencing (GO:0060147)2.82468299
162regulation of gene silencing by miRNA (GO:0060964)2.82468299
163lung lobe morphogenesis (GO:0060463)2.81529933
164oocyte maturation (GO:0001556)2.81144371
165positive regulation of interleukin-8 secretion (GO:2000484)2.80564694
166ventricular cardiac muscle cell development (GO:0055015)2.80022017
167positive regulation of osteoblast proliferation (GO:0033690)2.79604336
168negative regulation of T cell mediated immunity (GO:0002710)2.78693434
169regulation of exit from mitosis (GO:0007096)2.78355781
170regulation of apoptotic process involved in morphogenesis (GO:1902337)2.76559429
171regulation of protein polyubiquitination (GO:1902914)2.72498353
172histone exchange (GO:0043486)2.71632766
173translational termination (GO:0006415)2.69346529
174viral transcription (GO:0019083)2.69054833
175regulation of activin receptor signaling pathway (GO:0032925)2.67154540
176positive regulation of SMAD protein import into nucleus (GO:0060391)2.66944699
177cell fate commitment involved in formation of primary germ layer (GO:0060795)2.65466327
178nucleotide transmembrane transport (GO:1901679)2.64229057
179male sex determination (GO:0030238)2.63234152
180germ cell development (GO:0007281)2.57829893
181chaperone-mediated protein transport (GO:0072321)2.56612938
182folic acid transport (GO:0015884)2.52809838
183regulation of vasculogenesis (GO:2001212)2.48686389
184DNA catabolic process, exonucleolytic (GO:0000738)2.48234552
185regulation of retinoic acid receptor signaling pathway (GO:0048385)2.48210170
186translational initiation (GO:0006413)2.47677843
187negative regulation of gene silencing (GO:0060969)2.46628834
188positive regulation of cardiac muscle cell proliferation (GO:0060045)2.41460578
189heart contraction (GO:0060047)2.41004672
190heart process (GO:0003015)2.41004672
191negative regulation of fibroblast apoptotic process (GO:2000270)2.40181151
192negative regulation of nuclear division (GO:0051784)2.38638615
193parturition (GO:0007567)2.38531509
194reciprocal DNA recombination (GO:0035825)2.34993611
195regulation of meiosis I (GO:0060631)11.0697639
196bone trabecula formation (GO:0060346)10.5900353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.68678760
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.34915213
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.34915213
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.34915213
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.12430540
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.65960186
7GBX2_23144817_ChIP-Seq_PC3_Human3.25626099
8EZH2_22144423_ChIP-Seq_EOC_Human3.24258810
9HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse3.15796433
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.14152997
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95172663
12IGF1R_20145208_ChIP-Seq_DFB_Human2.88583177
13HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79090123
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.66399110
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.65301543
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.53613717
17FOXM1_23109430_ChIP-Seq_U2OS_Human2.51577815
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.47610080
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44327171
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.41759275
21ZNF274_21170338_ChIP-Seq_K562_Hela2.40731965
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.40553788
23PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36497132
24CBX2_27304074_Chip-Seq_ESCs_Mouse2.32992094
25SUZ12_27294783_Chip-Seq_NPCs_Mouse2.32139386
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27776828
27ESR1_21235772_ChIP-Seq_MCF-7_Human2.25729776
28SALL1_21062744_ChIP-ChIP_HESCs_Human2.19321905
29GABP_17652178_ChIP-ChIP_JURKAT_Human2.18990846
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.13310138
31BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13127619
32NFE2_27457419_Chip-Seq_LIVER_Mouse2.10747849
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07903247
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.07056652
35SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99742792
36SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.99667673
37RNF2_18974828_ChIP-Seq_MESCs_Mouse1.98697645
38EZH2_18974828_ChIP-Seq_MESCs_Mouse1.98697645
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.98465535
40JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96521697
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.96285788
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94723630
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.92387634
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91983260
45* EZH2_27294783_Chip-Seq_NPCs_Mouse1.91621218
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.85587932
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.85243765
48GATA1_26923725_Chip-Seq_HPCs_Mouse1.80638564
49E2F7_22180533_ChIP-Seq_HELA_Human1.79528285
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78673201
51VDR_22108803_ChIP-Seq_LS180_Human1.76825548
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.75099294
53STAT3_18555785_Chip-Seq_ESCs_Mouse1.75042632
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74472404
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72738091
56TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71129182
57P53_22387025_ChIP-Seq_ESCs_Mouse1.68733995
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68116800
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.68014674
60SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63091703
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.60932773
62ZNF263_19887448_ChIP-Seq_K562_Human1.60818683
63MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60773432
64* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60071201
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.59397473
66TTF2_22483619_ChIP-Seq_HELA_Human1.58815394
67SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58631961
68NMYC_18555785_Chip-Seq_ESCs_Mouse1.57520859
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.53884953
70CMYC_18555785_Chip-Seq_ESCs_Mouse1.53737499
71EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.51586709
72E2F1_18555785_Chip-Seq_ESCs_Mouse1.50325609
73SOX2_16153702_ChIP-ChIP_HESCs_Human1.48189834
74DROSHA_22980978_ChIP-Seq_HELA_Human1.47876614
75SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.47343703
76RNF2_27304074_Chip-Seq_NSC_Mouse1.45836491
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43463989
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.43284578
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.42958727
80IRF1_19129219_ChIP-ChIP_H3396_Human1.42919213
81SOX2_18555785_Chip-Seq_ESCs_Mouse1.41237203
82P300_18555785_Chip-Seq_ESCs_Mouse1.41057198
83TCF3_18692474_ChIP-Seq_MESCs_Mouse1.40822637
84PU1_27457419_Chip-Seq_LIVER_Mouse1.40032047
85CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39821557
86CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38941233
87EST1_17652178_ChIP-ChIP_JURKAT_Human1.38284475
88ZFX_18555785_Chip-Seq_ESCs_Mouse1.37961426
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37266785
90OCT4_18555785_Chip-Seq_ESCs_Mouse1.36810924
91TP53_18474530_ChIP-ChIP_U2OS_Human1.36728611
92TP53_20018659_ChIP-ChIP_R1E_Mouse1.36323642
93JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35908108
94DCP1A_22483619_ChIP-Seq_HELA_Human1.34548779
95HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33318296
96PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32295017
97AR_21909140_ChIP-Seq_LNCAP_Human1.31694499
98KDM2B_26808549_Chip-Seq_REH_Human1.31475054
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31317656
100TAF15_26573619_Chip-Seq_HEK293_Human1.29950526
101* CRX_20693478_ChIP-Seq_RETINA_Mouse1.28779136
102ESRRB_18555785_Chip-Seq_ESCs_Mouse1.28284924
103LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27928614
104TCF3_18692474_ChIP-Seq_MEFs_Mouse1.27049083
105CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27021175
106PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.26895584
107CTCF_18555785_Chip-Seq_ESCs_Mouse1.26825880
108* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26797767
109EWS_26573619_Chip-Seq_HEK293_Human1.26578563
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.26256787
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25556215
112RUNX1_27457419_Chip-Seq_LIVER_Mouse1.25375634
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25088597
114POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22623036
115KLF4_18555785_Chip-Seq_ESCs_Mouse1.22340770
116SMAD3_21741376_ChIP-Seq_EPCs_Human1.22215813
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22137064
118OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19750853
119SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19699823
120CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19478471
121E2F1_18555785_ChIP-Seq_MESCs_Mouse1.19445499
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17523532
123* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17092170
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16974493
125RING1B_27294783_Chip-Seq_ESCs_Mouse1.16186081
126ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16034388
127KAP1_22055183_ChIP-Seq_ESCs_Mouse1.15357017
128WT1_19549856_ChIP-ChIP_CCG9911_Human1.14682856
129PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14470706
130VDR_23849224_ChIP-Seq_CD4+_Human1.13126741
131ELK4_26923725_Chip-Seq_MESODERM_Mouse1.12715055
132TAL1_26923725_Chip-Seq_HPCs_Mouse1.10686577
133IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.10669961
134TP63_19390658_ChIP-ChIP_HaCaT_Human1.09886244
135RING1B_27294783_Chip-Seq_NPCs_Mouse1.08920983
136GF1_26923725_Chip-Seq_HPCs_Mouse1.08778961
137MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08550232
138THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08372868
139SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07489385
140ZFX_18555785_ChIP-Seq_MESCs_Mouse1.07417706
141SOX2_18555785_ChIP-Seq_MESCs_Mouse1.06651407
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06530040
143CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06165404
144ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05899900
145BCAT_22108803_ChIP-Seq_LS180_Human1.05697379
146SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05517120
147FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05309755
148LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04741850
149RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04300823
150FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04201087
151FOXH1_21741376_ChIP-Seq_EPCs_Human1.03778019
152POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02862251
153RUNX2_22187159_ChIP-Seq_PCA_Human1.02315255
154CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02245688
155NFYA_21822215_ChIP-Seq_K562_Human1.01955135
156MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01842647
157MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00978361
158SALL4_18804426_ChIP-ChIP_XEN_Mouse1.00248764
159ELK1_19687146_ChIP-ChIP_HELA_Human1.00151387
160NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98936257
161CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.98888922
162AR_19668381_ChIP-Seq_PC3_Human0.98722395
163CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97978144
164TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.97889514
165HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.96749835
166ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95407103
167EP300_21415370_ChIP-Seq_HL-1_Mouse0.95322393
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.94911685
169MYCN_18555785_ChIP-Seq_MESCs_Mouse0.94068082
170SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93610440
171NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93362219
172CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91948353
173TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91163320
174NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90611235
175ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.90173933
176ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.89544079
177NANOG_16518401_ChIP-PET_MESCs_Mouse0.86487115
178TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86028803
179FUS_26573619_Chip-Seq_HEK293_Human0.85414378
180NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83728488
181PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.83711229
182SMAD4_21741376_ChIP-Seq_EPCs_Human0.81389347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology8.47122523
2MP0003195_calcinosis5.06508061
3MP0005623_abnormal_meninges_morphology5.01057054
4MP0009384_cardiac_valve_regurgitation3.80249737
5MP0010030_abnormal_orbit_morphology3.55154452
6MP0001188_hyperpigmentation3.52659375
7MP0008877_abnormal_DNA_methylation3.34144207
8MP0003122_maternal_imprinting3.33801686
9MP0010368_abnormal_lymphatic_system3.11965800
10MP0000678_abnormal_parathyroid_gland2.87489346
11MP0005451_abnormal_body_composition2.65630906
12MP0008058_abnormal_DNA_repair2.64198674
13MP0010386_abnormal_urinary_bladder2.57412678
14MP0001986_abnormal_taste_sensitivity2.54683730
15MP0000579_abnormal_nail_morphology2.53980254
16MP0003123_paternal_imprinting2.50773255
17MP0000750_abnormal_muscle_regeneration2.47902209
18MP0006072_abnormal_retinal_apoptosis2.42501036
19MP0002210_abnormal_sex_determination2.41324736
20MP0008057_abnormal_DNA_replication2.28223636
21MP0008438_abnormal_cutaneous_collagen2.27764042
22MP0004957_abnormal_blastocyst_morpholog2.26602177
23MP0003693_abnormal_embryo_hatching2.25750868
24MP0004782_abnormal_surfactant_physiolog2.16357632
25MP0004484_altered_response_of2.13158110
26MP0003011_delayed_dark_adaptation1.98570614
27MP0001929_abnormal_gametogenesis1.97962768
28MP0001145_abnormal_male_reproductive1.87954735
29MP0003941_abnormal_skin_development1.86820127
30MP0003950_abnormal_plasma_membrane1.86143767
31MP0002160_abnormal_reproductive_system1.84024489
32MP0000653_abnormal_sex_gland1.83651623
33MP0000462_abnormal_digestive_system1.79741594
34MP0005275_abnormal_skin_tensile1.77407132
35MP0002249_abnormal_larynx_morphology1.72947566
36MP0000751_myopathy1.71999886
37MP0003121_genomic_imprinting1.68600007
38MP0004215_abnormal_myocardial_fiber1.67521236
39MP0003283_abnormal_digestive_organ1.65222368
40MP0009697_abnormal_copulation1.58227702
41MP0002638_abnormal_pupillary_reflex1.55525466
42MP0005174_abnormal_tail_pigmentation1.53699423
43MP0003698_abnormal_male_reproductive1.50576883
44MP0005171_absent_coat_pigmentation1.49081690
45MP0000749_muscle_degeneration1.47412723
46MP0002108_abnormal_muscle_morphology1.45224957
47MP0001879_abnormal_lymphatic_vessel1.43743633
48MP0002168_other_aberrant_phenotype1.35116034
49MP0003385_abnormal_body_wall1.34028956
50MP0005670_abnormal_white_adipose1.33823200
51MP0001542_abnormal_bone_strength1.32524622
52MP0005423_abnormal_somatic_nervous1.31725727
53MP0003567_abnormal_fetal_cardiomyocyte1.31625238
54MP0001661_extended_life_span1.29695481
55MP0003186_abnormal_redox_activity1.29451261
56MP0005503_abnormal_tendon_morphology1.27688650
57MP0000767_abnormal_smooth_muscle1.27653074
58MP0005410_abnormal_fertilization1.25850724
59MP0009764_decreased_sensitivity_to1.25367534
60MP0004036_abnormal_muscle_relaxation1.25057632
61MP0002282_abnormal_trachea_morphology1.23048138
62MP0003119_abnormal_digestive_system1.23012655
63MP0003942_abnormal_urinary_system1.21186794
64MP0001730_embryonic_growth_arrest1.20530586
65MP0004142_abnormal_muscle_tone1.20490947
66MP0003111_abnormal_nucleus_morphology1.19880388
67MP0003646_muscle_fatigue1.19459349
68MP0005165_increased_susceptibility_to1.18506839
69MP0003938_abnormal_ear_development1.17828462
70MP0004742_abnormal_vestibular_system1.16194852
71MP0009379_abnormal_foot_pigmentation1.15424911
72MP0000383_abnormal_hair_follicle1.14158610
73MP0002736_abnormal_nociception_after1.13175431
74MP0001486_abnormal_startle_reflex1.12707099
75MP0002163_abnormal_gland_morphology1.11610499
76MP0002106_abnormal_muscle_physiology1.07236540
77MP0004019_abnormal_vitamin_homeostasis1.05049446
78MP0002084_abnormal_developmental_patter1.03909142
79MP0005330_cardiomyopathy1.03884465
80MP0005253_abnormal_eye_physiology1.03705021
81MP0010094_abnormal_chromosome_stability1.03457349
82MP0003718_maternal_effect1.03002914
83MP0003077_abnormal_cell_cycle1.02120144
84MP0003935_abnormal_craniofacial_develop1.01278402
85MP0002085_abnormal_embryonic_tissue0.99756693
86MP0004885_abnormal_endolymph0.98832995
87MP0000490_abnormal_crypts_of0.96467872
88MP0005395_other_phenotype0.96402688
89MP0010307_abnormal_tumor_latency0.95130906
90MP0004858_abnormal_nervous_system0.92442485
91MP0002161_abnormal_fertility/fecundity0.92111389
92MP0003936_abnormal_reproductive_system0.92095130
93MP0004084_abnormal_cardiac_muscle0.91449327
94MP0001958_emphysema0.90942172
95MP0000534_abnormal_ureter_morphology0.89431213
96MP0005385_cardiovascular_system_phenoty0.89190455
97MP0001544_abnormal_cardiovascular_syste0.89190455
98MP0005389_reproductive_system_phenotype0.87848951
99MP0000733_abnormal_muscle_development0.87584385
100MP0008932_abnormal_embryonic_tissue0.85880493
101MP0002269_muscular_atrophy0.85349704
102MP0010678_abnormal_skin_adnexa0.83132140
103MP0003806_abnormal_nucleotide_metabolis0.82671895
104MP0006054_spinal_hemorrhage0.82339522
105MP0005551_abnormal_eye_electrophysiolog0.81730513
106MP0000049_abnormal_middle_ear0.81016531
107MP0004147_increased_porphyrin_level0.80456667
108MP0002127_abnormal_cardiovascular_syste0.80384870
109MP0000013_abnormal_adipose_tissue0.79712864
110MP0000163_abnormal_cartilage_morphology0.79522333
111MP0010352_gastrointestinal_tract_polyps0.79326450
112MP0000762_abnormal_tongue_morphology0.79297876
113MP0008004_abnormal_stomach_pH0.79009233
114MP0005167_abnormal_blood-brain_barrier0.78595007
115MP0008775_abnormal_heart_ventricle0.77776438
116MP0001502_abnormal_circadian_rhythm0.76986837
117MP0008995_early_reproductive_senescence0.76193905
118MP0005388_respiratory_system_phenotype0.74660128
119MP0002133_abnormal_respiratory_system0.74660128
120MP0000358_abnormal_cell_content/0.73965276
121MP0005380_embryogenesis_phenotype0.73499834
122MP0001672_abnormal_embryogenesis/_devel0.73499834
123MP0001177_atelectasis0.73303473
124MP0002837_dystrophic_cardiac_calcinosis0.72992884
125MP0000266_abnormal_heart_morphology0.71955299
126MP0001119_abnormal_female_reproductive0.70725569
127MP0005379_endocrine/exocrine_gland_phen0.70235736
128MP0005595_abnormal_vascular_smooth0.70017058
129MP0005369_muscle_phenotype0.69986990
130MP0002972_abnormal_cardiac_muscle0.69719955
131MP0002938_white_spotting0.69387024
132MP0004145_abnormal_muscle_electrophysio0.69133052
133MP0005197_abnormal_uvea_morphology0.68008785
134MP0002697_abnormal_eye_size0.66558503
135MP0003699_abnormal_female_reproductive0.66389741
136MP0000026_abnormal_inner_ear0.65291149
137MP0006035_abnormal_mitochondrial_morpho0.64850447
138MP0002932_abnormal_joint_morphology0.64554384
139MP0004133_heterotaxia0.63550645
140MP0000427_abnormal_hair_cycle0.59751125
141MP0008260_abnormal_autophagy0.58784176
142MP0002184_abnormal_innervation0.58566973
143MP0009785_altered_susceptibility_to0.58355428
144MP0001968_abnormal_touch/_nociception0.57038142
145MP0002060_abnormal_skin_morphology0.55914979
146MP0000516_abnormal_urinary_system0.55830165
147MP0005367_renal/urinary_system_phenotyp0.55830165
148MP0006138_congestive_heart_failure0.55647381
149MP0001664_abnormal_digestion0.55461351
150MP0000230_abnormal_systemic_arterial0.55007119
151MP0003755_abnormal_palate_morphology0.54429598
152MP0003279_aneurysm0.53660504
153MP0002295_abnormal_pulmonary_circulatio0.52579252
154MP0005085_abnormal_gallbladder_physiolo0.52226127
155MP0001919_abnormal_reproductive_system0.51499218
156MP0002876_abnormal_thyroid_physiology0.50867931
157MP0001346_abnormal_lacrimal_gland0.48432297
158MP0003937_abnormal_limbs/digits/tail_de0.47135569
159MP0009250_abnormal_appendicular_skeleto0.46230677
160MP0004272_abnormal_basement_membrane0.44358784
161MP0002752_abnormal_somatic_nervous0.44029261
162MP0005645_abnormal_hypothalamus_physiol0.42607499
163MP0005391_vision/eye_phenotype0.41936026
164MP0002896_abnormal_bone_mineralization0.41898837
165MP0005620_abnormal_muscle_contractility0.40950381

Predicted human phenotypes

RankGene SetZ-score
1Split foot (HP:0001839)9.87538207
2Oligodactyly (hands) (HP:0001180)9.32280277
3Severe visual impairment (HP:0001141)8.02267767
4Absent hand (HP:0004050)7.40637587
5Oligodactyly (HP:0012165)6.50878427
6Pendular nystagmus (HP:0012043)6.44192732
7Abnormality of macular pigmentation (HP:0008002)5.55916218
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.76852714
9Shoulder girdle muscle weakness (HP:0003547)3.97651053
10Stenosis of the external auditory canal (HP:0000402)3.81270685
11Osteomalacia (HP:0002749)3.81149955
12Abnormality of abdominal situs (HP:0011620)3.80903403
13Abdominal situs inversus (HP:0003363)3.80903403
14Severe Myopia (HP:0011003)3.80614816
15Mesangial abnormality (HP:0001966)3.74340336
16Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.70361519
17Degeneration of the lateral corticospinal tracts (HP:0002314)3.70361519
18Increased circulating renin level (HP:0000848)3.65160697
19Agitation (HP:0000713)3.63047820
20Mesomelia (HP:0003027)3.59116313
21Renal duplication (HP:0000075)3.35371382
22Abnormality of the renal collecting system (HP:0004742)3.33778043
23Striae distensae (HP:0001065)3.32163330
24Abnormality of the costochondral junction (HP:0000919)3.23581416
25Meckel diverticulum (HP:0002245)3.22160243
26Recurrent corneal erosions (HP:0000495)3.18966863
27Reticulocytopenia (HP:0001896)3.18645238
28Abnormality of the lower motor neuron (HP:0002366)3.05869022
29Rimmed vacuoles (HP:0003805)3.04829538
30Abnormality of the corticospinal tract (HP:0002492)3.03073926
31Hyperphosphatemia (HP:0002905)3.02949652
32Abnormality of the ileum (HP:0001549)3.02295830
33Asymmetry of the thorax (HP:0001555)2.97937842
34Alveolar cell carcinoma (HP:0006519)2.97205201
35Ectopic kidney (HP:0000086)2.90329889
36Tetany (HP:0001281)2.88962628
37Scotoma (HP:0000575)2.88931267
38Duplication of thumb phalanx (HP:0009942)2.85704789
39Abnormality of the vocal cords (HP:0008777)2.82775729
40Metaphyseal irregularity (HP:0003025)2.82187325
41Short tibia (HP:0005736)2.81856752
42Hydroureter (HP:0000072)2.79991095
43Hypomagnesemia (HP:0002917)2.75996156
44Absent toe (HP:0010760)2.75916829
45Conical tooth (HP:0000698)2.71455052
46Horizontal nystagmus (HP:0000666)2.70095843
47Flat capital femoral epiphysis (HP:0003370)2.69566890
48Type 1 muscle fiber predominance (HP:0003803)2.69559529
49Ankle contracture (HP:0006466)2.68707210
50Type 2 muscle fiber atrophy (HP:0003554)2.62688524
51Cerebral hypomyelination (HP:0006808)2.61309980
52Neoplasm of the tracheobronchial system (HP:0100552)2.59097895
53Hyperglycinuria (HP:0003108)2.52268332
54Hypercortisolism (HP:0001578)2.49444926
55Upper limb muscle weakness (HP:0003484)2.47630646
56Limb-girdle muscle weakness (HP:0003325)2.46607102
57Aplasia/Hypoplasia of the spleen (HP:0010451)2.45250857
58Gonadotropin excess (HP:0000837)2.43354466
59Nephroblastoma (Wilms tumor) (HP:0002667)2.39924893
60Abnormality of the shoulder girdle musculature (HP:0001435)2.37728482
61Aplasia/Hypoplasia of the tibia (HP:0005772)2.37374664
62Agnosia (HP:0010524)2.37172663
63Abnormal umbilical cord blood vessels (HP:0011403)2.34312436
64Single umbilical artery (HP:0001195)2.34312436
65Abnormality of the fetal cardiovascular system (HP:0010948)2.34312436
66Muscle stiffness (HP:0003552)2.33588043
67Aortic aneurysm (HP:0004942)2.33459337
68Embryonal renal neoplasm (HP:0011794)2.33387059
69Abnormality of calcium-phosphate metabolism (HP:0100530)2.31798498
70Ependymoma (HP:0002888)2.30153778
71Facial cleft (HP:0002006)2.28959753
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28792566
73Absent radius (HP:0003974)2.28612123
74Optic neuritis (HP:0100653)2.27977555
75Retrobulbar optic neuritis (HP:0100654)2.27977555
76Duplicated collecting system (HP:0000081)2.26840573
77Partial duplication of the phalanx of hand (HP:0009999)2.25125528
78Supernumerary spleens (HP:0009799)2.24607860
79Abnormality of B cell number (HP:0010975)2.23434800
80B lymphocytopenia (HP:0010976)2.23434800
81Abnormality of magnesium homeostasis (HP:0004921)2.23146886
82Muscle fiber splitting (HP:0003555)2.23106205
83Carpal bone hypoplasia (HP:0001498)2.22398601
84Intellectual disability, moderate (HP:0002342)2.21699406
85Muscle fiber atrophy (HP:0100295)2.21491279
86Anomalous pulmonary venous return (HP:0010772)2.21194574
87Fused cervical vertebrae (HP:0002949)2.12665301
88Asplenia (HP:0001746)2.11091447
89Abnormality of renin-angiotensin system (HP:0000847)2.10113437
90CNS hypomyelination (HP:0003429)2.07932315
91Abnormality of cells of the erythroid lineage (HP:0012130)2.07087309
92Aplasia involving forearm bones (HP:0009822)2.06892746
93Absent forearm bone (HP:0003953)2.06892746
94Neonatal short-limb short stature (HP:0008921)2.06342887
95Absent thumb (HP:0009777)2.06189513
96Abnormality of the phalanges of the hallux (HP:0010057)2.04890931
97Amyotrophic lateral sclerosis (HP:0007354)2.03458964
98Polydipsia (HP:0001959)2.02508502
99Abnormal drinking behavior (HP:0030082)2.02508502
100Hypoplasia of the uterus (HP:0000013)2.01446146
101Horseshoe kidney (HP:0000085)1.99768459
102Cutaneous finger syndactyly (HP:0010554)1.98827322
103Truncal obesity (HP:0001956)1.98352354
104Upper motor neuron abnormality (HP:0002127)1.97977092
105Shawl scrotum (HP:0000049)1.97676419
106Duodenal stenosis (HP:0100867)1.97393166
107Small intestinal stenosis (HP:0012848)1.97393166
108Short hallux (HP:0010109)1.95962609
109Orchitis (HP:0100796)1.95951309
110Secondary amenorrhea (HP:0000869)1.95400407
111Abnormal connection of the cardiac segments (HP:0011545)1.95111119
112Abnormal ventriculo-arterial connection (HP:0011563)1.95111119
113Transposition of the great arteries (HP:0001669)1.95111119
114Tongue fasciculations (HP:0001308)1.94501729
115Hypoplastic left heart (HP:0004383)1.94295446
116Distal lower limb amyotrophy (HP:0008944)1.93802196
117Distal lower limb muscle weakness (HP:0009053)1.93295609
118Abnormal urine phosphate concentration (HP:0012599)1.92971919
119Basal ganglia calcification (HP:0002135)1.91598024
120Akinesia (HP:0002304)1.89485828
121Midline defect of the nose (HP:0004122)1.88745200
122Hypophosphatemic rickets (HP:0004912)1.87982160
123Absent phalangeal crease (HP:0006109)1.87006302
124Aplasia/Hypoplasia of the hallux (HP:0008362)1.85934346
125Delayed epiphyseal ossification (HP:0002663)1.85021292
126Redundant skin (HP:0001582)1.83366310
127Chromsome breakage (HP:0040012)1.83253661
128Absent/shortened dynein arms (HP:0200106)1.82970190
129Dynein arm defect of respiratory motile cilia (HP:0012255)1.82970190
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.82795006
131Triphalangeal thumb (HP:0001199)1.82709863
132Incomplete penetrance (HP:0003829)1.82466241
133Volvulus (HP:0002580)1.80907008
134Abnormality of the labia minora (HP:0012880)1.79707720
135Annular pancreas (HP:0001734)1.77949551
136Aplasia/hypoplasia of the uterus (HP:0008684)1.76538756
137Premature rupture of membranes (HP:0001788)1.76245697
138Aplasia/Hypoplasia involving the musculature (HP:0001460)1.76065659
139Rectovaginal fistula (HP:0000143)1.76063944
140Rectal fistula (HP:0100590)1.76063944
141Adrenal overactivity (HP:0002717)1.75547188
142Cortical dysplasia (HP:0002539)1.75079745
143Macular degeneration (HP:0000608)1.74801157
144Anteriorly placed anus (HP:0001545)1.74653576
145Aplasia/Hypoplasia of the uvula (HP:0010293)1.74626072
146Male pseudohermaphroditism (HP:0000037)1.74560547
147Aplasia/Hypoplasia of the sacrum (HP:0008517)1.73096737
148Ureteral duplication (HP:0000073)1.73085503
149Corneal erosion (HP:0200020)1.72963552
150Muscle fibrillation (HP:0010546)1.72593568
151Pili torti (HP:0003777)1.72507760
152Bilateral microphthalmos (HP:0007633)1.72187836
153Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71907503
154Neonatal respiratory distress (HP:0002643)1.71715767
155Microvesicular hepatic steatosis (HP:0001414)1.71647482
156Aortic valve stenosis (HP:0001650)1.70612738
157Nemaline bodies (HP:0003798)1.70269239
158Partial duplication of thumb phalanx (HP:0009944)1.69956053
159Congenital sensorineural hearing impairment (HP:0008527)1.69482780
160Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.69139588
161Resting tremor (HP:0002322)1.68864251
162Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68612479
163Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68612479
164Opisthotonus (HP:0002179)1.67881670
165Keratoconus (HP:0000563)1.67654584
166Increased corneal curvature (HP:0100692)1.67654584
167Generalized myoclonic seizures (HP:0002123)1.67604262
168Depression (HP:0000716)1.67566663
169Abnormal number of erythroid precursors (HP:0012131)1.67503080
170Urinary urgency (HP:0000012)1.67342974
171Split hand (HP:0001171)1.67024328
172Abnormality of the pulmonary veins (HP:0011718)1.65970489
173Congenital, generalized hypertrichosis (HP:0004540)1.64068040
174Lower limb amyotrophy (HP:0007210)1.63010253
175Restlessness (HP:0000711)1.62440727
176Abnormality of the preputium (HP:0100587)1.61547901
177Stage 5 chronic kidney disease (HP:0003774)1.60981721
178Abnormal lung lobation (HP:0002101)1.60624732
179Hepatoblastoma (HP:0002884)1.58140118
180Anxiety (HP:0000739)1.57066684
181Myositis (HP:0100614)1.56088330
182Keratoconjunctivitis sicca (HP:0001097)1.55767023
183Hypophosphatemia (HP:0002148)1.55573756
184Hyperphosphaturia (HP:0003109)1.54382788

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.55418484
2PNCK5.46195061
3BUB14.75779195
4EIF2AK24.56792586
5CDK194.53429589
6MYLK3.15934166
7EPHA32.69767788
8PBK2.39958719
9STK162.37701687
10BLK2.33288413
11TNK22.21793871
12WEE12.17292226
13LATS22.09071011
14MAP3K142.04789620
15CDC72.04571403
16UHMK12.01251631
17FRK1.96716261
18STK241.84370850
19CDK81.79798078
20STK38L1.77693257
21TNIK1.75958993
22PRKCG1.68642132
23PAK31.61670034
24BMX1.58983527
25TTK1.55355440
26PAK21.46384823
27PTK2B1.43982964
28NEK21.43018540
29STK31.42789734
30CSF1R1.39274271
31IRAK11.35893310
32NEK91.33564561
33STK391.32087649
34ZAK1.31142867
35PASK1.28714254
36PRPF4B1.27700604
37NME21.27035370
38AKT31.25333972
39GRK11.25087158
40PRKD31.24074785
41MKNK21.21998509
42KSR21.19190229
43SRPK11.16779114
44WNK11.16172648
45TLK11.12931608
46LIMK11.09998770
47CAMK11.07760408
48BRSK21.06815496
49CAMK2G1.06578105
50TGFBR11.04878789
51AURKA1.04112568
52ADRBK11.04008734
53KDR1.03742367
54OBSCN1.02051414
55PRKCH1.00422435
56KIT1.00332381
57CAMK40.99727365
58PDGFRA0.97365163
59ADRBK20.96125253
60MATK0.95381041
61BRAF0.94307171
62DDR20.93252082
63MAP3K20.92713519
64CAMK2A0.91528616
65EPHA20.90057403
66PKN10.89743032
67PDK20.88995474
68JAK10.88849436
69EPHA40.88683919
70TIE10.88041259
71MAP3K120.87550089
72PLK40.87390022
73MAP2K60.84390694
74STK380.83850455
75PRKCE0.83635202
76ACVR1B0.83507505
77BMPR1B0.79268559
78ERBB40.78736532
79DYRK30.78415356
80ALK0.76534152
81CHEK20.73479068
82MET0.72237378
83DYRK20.71723124
84PINK10.70479146
85TAOK20.70416774
86PIK3CA0.70235161
87CDK70.70010050
88WNK40.69358926
89EPHB20.67442538
90STK110.66861669
91PLK10.65711784
92IKBKE0.64861285
93TBK10.63716299
94PRKG10.63468303
95PIK3CG0.62235488
96PTK20.61307215
97RPS6KC10.61168600
98RPS6KL10.61168600
99CHEK10.60370850
100TESK10.60279214
101STK40.58433345
102ITK0.58195701
103PHKG10.58115039
104PHKG20.58115039
105MKNK10.57661448
106ATM0.56750132
107INSR0.56073343
108PLK20.55888246
109CDK30.52276125
110SGK20.52132386
111MAP3K70.51193512
112OXSR10.51155706
113PRKACA0.50686249
114NTRK20.50677622
115TEC0.48485490
116SCYL20.48439910
117ABL20.48012004
118VRK10.47619125
119RAF10.47317647
120PDGFRB0.47011841
121RPS6KA60.46435176
122AKT20.46247726
123PRKG20.45385925
124PTK60.45266621
125ROCK10.44823294
126AURKB0.43622844
127NTRK30.43489458
128TRPM70.42904260
129FER0.42812230
130PLK30.42225619
131IRAK30.41824002
132ATR0.41594896
133MUSK0.40904316
134INSRR0.40287964
135PRKCA0.39149726
136MELK0.38594437
137CSNK2A10.38571607
138FGR0.38531388
139BRSK10.38104966
140MAP3K40.37877758
141CAMK1G0.37685619
142MARK10.37535249
143PAK40.37416892
144PRKCB0.37349093
145BMPR20.37249736
146MAP3K60.34883920
147CAMK1D0.34280879
148PIM10.33932045
149CSNK2A20.33843789
150TYRO30.33419702
151PRKCD0.33403697
152RPS6KA10.33152865
153DAPK30.31806812
154MAP3K80.31736828
155CSNK1G20.31508403
156LATS10.31143442
157MAPK130.29554182
158DMPK0.27939029
159YES10.27828233
160LYN0.26512458
161CSNK1D0.26182361

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007604.35677590
2Folate biosynthesis_Homo sapiens_hsa007904.24407349
3Ribosome_Homo sapiens_hsa030103.94422587
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.37002056
5Hedgehog signaling pathway_Homo sapiens_hsa043403.26470795
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.09353105
7Mismatch repair_Homo sapiens_hsa034303.06300158
8Basal cell carcinoma_Homo sapiens_hsa052173.01601366
9DNA replication_Homo sapiens_hsa030302.76852302
10beta-Alanine metabolism_Homo sapiens_hsa004102.67009581
11Histidine metabolism_Homo sapiens_hsa003402.64158720
12Vascular smooth muscle contraction_Homo sapiens_hsa042702.58570839
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49914232
14Arginine and proline metabolism_Homo sapiens_hsa003302.28989829
15RNA transport_Homo sapiens_hsa030132.27852847
16Tryptophan metabolism_Homo sapiens_hsa003802.22195886
17Hippo signaling pathway_Homo sapiens_hsa043902.18917063
18RNA polymerase_Homo sapiens_hsa030202.14712439
19Autoimmune thyroid disease_Homo sapiens_hsa053202.00184307
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.98002341
21Basal transcription factors_Homo sapiens_hsa030221.91906679
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.84550359
23Small cell lung cancer_Homo sapiens_hsa052221.84100708
24Ovarian steroidogenesis_Homo sapiens_hsa049131.84092729
25Insulin secretion_Homo sapiens_hsa049111.79329784
26Sulfur relay system_Homo sapiens_hsa041221.73473401
27Morphine addiction_Homo sapiens_hsa050321.67423796
28Dorso-ventral axis formation_Homo sapiens_hsa043201.65942059
29Calcium signaling pathway_Homo sapiens_hsa040201.61210034
30Nucleotide excision repair_Homo sapiens_hsa034201.59662617
31Fatty acid elongation_Homo sapiens_hsa000621.58176250
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48658935
33Retinol metabolism_Homo sapiens_hsa008301.45663724
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.40474989
35Melanogenesis_Homo sapiens_hsa049161.37233439
36RNA degradation_Homo sapiens_hsa030181.35228935
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.32855887
38Fatty acid degradation_Homo sapiens_hsa000711.29398874
39mRNA surveillance pathway_Homo sapiens_hsa030151.26667818
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24340121
41Circadian entrainment_Homo sapiens_hsa047131.23864555
42ECM-receptor interaction_Homo sapiens_hsa045121.22888291
43Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.20914786
44Glycosaminoglycan degradation_Homo sapiens_hsa005311.20366786
45Caffeine metabolism_Homo sapiens_hsa002321.19504906
46Wnt signaling pathway_Homo sapiens_hsa043101.19255880
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16073457
48Cell cycle_Homo sapiens_hsa041101.13515759
49ABC transporters_Homo sapiens_hsa020101.11907349
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09310995
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.09289474
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08909607
53cAMP signaling pathway_Homo sapiens_hsa040241.08893261
54Pyrimidine metabolism_Homo sapiens_hsa002401.06490877
55Nicotine addiction_Homo sapiens_hsa050331.02847457
56Protein digestion and absorption_Homo sapiens_hsa049741.02733291
57Pathways in cancer_Homo sapiens_hsa052001.01992983
58Proteoglycans in cancer_Homo sapiens_hsa052050.95208645
59Arachidonic acid metabolism_Homo sapiens_hsa005900.94663259
60Protein export_Homo sapiens_hsa030600.94658710
61p53 signaling pathway_Homo sapiens_hsa041150.94144156
62Propanoate metabolism_Homo sapiens_hsa006400.92816976
63Intestinal immune network for IgA production_Homo sapiens_hsa046720.92478277
64Huntingtons disease_Homo sapiens_hsa050160.91967527
65Axon guidance_Homo sapiens_hsa043600.90325237
66Dilated cardiomyopathy_Homo sapiens_hsa054140.85033215
67Renin secretion_Homo sapiens_hsa049240.84313667
68Steroid biosynthesis_Homo sapiens_hsa001000.84312170
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.83784910
70Long-term depression_Homo sapiens_hsa047300.83712909
71Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83068632
72Cardiac muscle contraction_Homo sapiens_hsa042600.81934191
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80388477
74Fanconi anemia pathway_Homo sapiens_hsa034600.79937648
75Selenocompound metabolism_Homo sapiens_hsa004500.76049170
76Arginine biosynthesis_Homo sapiens_hsa002200.75141059
77Complement and coagulation cascades_Homo sapiens_hsa046100.74949096
78Glutamatergic synapse_Homo sapiens_hsa047240.74665281
79Parkinsons disease_Homo sapiens_hsa050120.72873708
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72351076
81HTLV-I infection_Homo sapiens_hsa051660.72340977
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.72114357
83Glutathione metabolism_Homo sapiens_hsa004800.68496540
84Fatty acid biosynthesis_Homo sapiens_hsa000610.68420343
85Oxidative phosphorylation_Homo sapiens_hsa001900.67975862
86Oocyte meiosis_Homo sapiens_hsa041140.67114788
87One carbon pool by folate_Homo sapiens_hsa006700.66293562
88Cholinergic synapse_Homo sapiens_hsa047250.63115924
89Spliceosome_Homo sapiens_hsa030400.63058505
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62858900
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61680876
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61386421
93Purine metabolism_Homo sapiens_hsa002300.61172101
94Proteasome_Homo sapiens_hsa030500.60773016
95Circadian rhythm_Homo sapiens_hsa047100.60310386
96Focal adhesion_Homo sapiens_hsa045100.59035145
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58933466
98TNF signaling pathway_Homo sapiens_hsa046680.58592121
99Ether lipid metabolism_Homo sapiens_hsa005650.58540359
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.56755433
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55405317
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54775780
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.54731986
104Vitamin B6 metabolism_Homo sapiens_hsa007500.54558567
105Butanoate metabolism_Homo sapiens_hsa006500.54378426
106Phagosome_Homo sapiens_hsa041450.54341766
107mTOR signaling pathway_Homo sapiens_hsa041500.53487028
108Regulation of autophagy_Homo sapiens_hsa041400.52005424
109Homologous recombination_Homo sapiens_hsa034400.51680230
110Fatty acid metabolism_Homo sapiens_hsa012120.51153294
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.49362832
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49135683
113Phototransduction_Homo sapiens_hsa047440.49107422
114Base excision repair_Homo sapiens_hsa034100.46404934
115Ras signaling pathway_Homo sapiens_hsa040140.46181578
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.45955925
117Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45707175
118TGF-beta signaling pathway_Homo sapiens_hsa043500.45689868
119Lysine degradation_Homo sapiens_hsa003100.45497276
120Inositol phosphate metabolism_Homo sapiens_hsa005620.45465884
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45004976
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.44800826
123Melanoma_Homo sapiens_hsa052180.44042621
124Non-homologous end-joining_Homo sapiens_hsa034500.43881801
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.42936570
126Prostate cancer_Homo sapiens_hsa052150.41878341
127Gap junction_Homo sapiens_hsa045400.41742368
128Rap1 signaling pathway_Homo sapiens_hsa040150.41500353
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.40290712
130Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38362798
131Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37595284
132Alzheimers disease_Homo sapiens_hsa050100.37505700
133Malaria_Homo sapiens_hsa051440.37479443
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35134768
135Platelet activation_Homo sapiens_hsa046110.35076269
136Linoleic acid metabolism_Homo sapiens_hsa005910.34933183
137GABAergic synapse_Homo sapiens_hsa047270.33649280
138Olfactory transduction_Homo sapiens_hsa047400.33560397
139Adherens junction_Homo sapiens_hsa045200.33005155
140Starch and sucrose metabolism_Homo sapiens_hsa005000.32562740
141MicroRNAs in cancer_Homo sapiens_hsa052060.32117581
142Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.31811364
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.31760831
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31272361
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.30089801
146Tyrosine metabolism_Homo sapiens_hsa003500.28909890
147Amoebiasis_Homo sapiens_hsa051460.28360567
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27298408
149Herpes simplex infection_Homo sapiens_hsa051680.27192891
150Collecting duct acid secretion_Homo sapiens_hsa049660.26808038
151Tight junction_Homo sapiens_hsa045300.24079968

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