FAM163A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1phenol-containing compound catabolic process (GO:0019336)7.19951800
2enteric nervous system development (GO:0048484)6.35326656
3locomotory exploration behavior (GO:0035641)5.78707402
4neuron cell-cell adhesion (GO:0007158)5.70730233
5sperm motility (GO:0030317)5.60945717
6response to pheromone (GO:0019236)5.29042033
7acrosome reaction (GO:0007340)5.16270337
8centriole replication (GO:0007099)4.98736728
9protein polyglutamylation (GO:0018095)4.96821685
10amino acid import (GO:0043090)4.58427909
11L-amino acid import (GO:0043092)4.41621160
12positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.36654581
13behavioral response to nicotine (GO:0035095)4.34521925
14regulation of short-term neuronal synaptic plasticity (GO:0048172)4.28595716
15microtubule depolymerization (GO:0007019)4.26053449
16C4-dicarboxylate transport (GO:0015740)4.14983238
17exploration behavior (GO:0035640)4.13850018
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.00396839
19single strand break repair (GO:0000012)3.98735484
20regulation of secondary heart field cardioblast proliferation (GO:0003266)3.98317523
21regulation of cardioblast proliferation (GO:0003264)3.98317523
22establishment of protein localization to Golgi (GO:0072600)3.92260383
23sympathetic nervous system development (GO:0048485)3.87233430
24synaptic vesicle exocytosis (GO:0016079)3.86850373
25spermatid development (GO:0007286)3.86387121
26protein targeting to Golgi (GO:0000042)3.84901756
27regulation of synaptic vesicle exocytosis (GO:2000300)3.83948375
28epithelial cilium movement (GO:0003351)3.81540083
29auditory behavior (GO:0031223)3.77592701
30neurotransmitter secretion (GO:0007269)3.76598174
31sperm-egg recognition (GO:0035036)3.72736815
32neurotransmitter catabolic process (GO:0042135)3.68891596
33fusion of sperm to egg plasma membrane (GO:0007342)3.68724805
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.66076734
35regulation of beta-amyloid formation (GO:1902003)3.64490106
36synaptic vesicle maturation (GO:0016188)3.63387272
37centriole assembly (GO:0098534)3.58987516
38positive regulation of glomerulus development (GO:0090193)3.56598106
39regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.56146048
40response to auditory stimulus (GO:0010996)3.55555551
41regulation of amyloid precursor protein catabolic process (GO:1902991)3.53921129
42rRNA methylation (GO:0031167)3.53573159
43detection of light stimulus involved in visual perception (GO:0050908)3.53435591
44detection of light stimulus involved in sensory perception (GO:0050962)3.53435591
45calcium ion-dependent exocytosis (GO:0017156)3.51847709
46multicellular organism reproduction (GO:0032504)3.51422401
47retrograde transport, vesicle recycling within Golgi (GO:0000301)3.47880039
48regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.46727208
49phosphatidylethanolamine metabolic process (GO:0046337)3.44285472
50microtubule polymerization or depolymerization (GO:0031109)3.40771711
51regulation of synaptic vesicle transport (GO:1902803)3.40193192
52neurotransmitter-gated ion channel clustering (GO:0072578)3.39138318
53positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.38555847
54vocalization behavior (GO:0071625)3.38191846
55positive regulation of transcription regulatory region DNA binding (GO:2000679)3.37714941
56regulation of synaptic transmission, glutamatergic (GO:0051966)3.37112696
57phosphatidylethanolamine biosynthetic process (GO:0006646)3.36066241
58pyrimidine nucleobase catabolic process (GO:0006208)3.35673918
59postsynaptic membrane organization (GO:0001941)3.33688153
60neuromuscular synaptic transmission (GO:0007274)3.33564690
61cellular ketone body metabolic process (GO:0046950)3.31442272
62seminiferous tubule development (GO:0072520)3.30852966
63axoneme assembly (GO:0035082)3.28698749
64regulation of cilium movement (GO:0003352)3.28483635
65presynaptic membrane assembly (GO:0097105)3.28311633
66long-term synaptic potentiation (GO:0060291)3.27502270
67protein localization to synapse (GO:0035418)3.27299852
68dopamine metabolic process (GO:0042417)3.27257329
69neurotransmitter transport (GO:0006836)3.26905234
70mechanosensory behavior (GO:0007638)3.26831909
71cardiac ventricle formation (GO:0003211)3.26817204
72dendritic spine morphogenesis (GO:0060997)3.26314004
73negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.25955186
74piRNA metabolic process (GO:0034587)3.24022523
75negative regulation of cytosolic calcium ion concentration (GO:0051481)3.21172580
76rRNA modification (GO:0000154)3.21028263
77catecholamine transport (GO:0051937)3.20907700
78proline transport (GO:0015824)3.20871367
79fat-soluble vitamin catabolic process (GO:0042363)3.20480983
80vitamin catabolic process (GO:0009111)3.20480983
81glutamate secretion (GO:0014047)3.15279568
82regulation of respiratory system process (GO:0044065)3.15226221
83protein localization to Golgi apparatus (GO:0034067)3.15141200
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.14284428
85regulation of respiratory gaseous exchange (GO:0043576)3.14106659
86ketone body metabolic process (GO:1902224)3.10426225
87atrial cardiac muscle cell action potential (GO:0086014)3.08846464
88primary amino compound metabolic process (GO:1901160)3.08738086
89cilium or flagellum-dependent cell motility (GO:0001539)3.08047481
90positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06457439
91detection of calcium ion (GO:0005513)3.03487610
92cell migration in hindbrain (GO:0021535)3.03314211
93plasma membrane fusion (GO:0045026)3.02318523
94behavioral response to ethanol (GO:0048149)3.02035029
95regulation of action potential (GO:0098900)3.00138062
96cilium movement (GO:0003341)2.98536802
97cardiac chamber formation (GO:0003207)2.98316210
98binding of sperm to zona pellucida (GO:0007339)2.98054785
99positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.97466065
100regulation of glutamate receptor signaling pathway (GO:1900449)2.97396517
101cell-cell recognition (GO:0009988)2.97169939
102negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96640870
103male gamete generation (GO:0048232)2.96492701
104G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.96426145
105spermatogenesis (GO:0007283)2.96343423
106regulation of neurotransmitter secretion (GO:0046928)2.96192414
107synaptic vesicle docking involved in exocytosis (GO:0016081)2.96169358
108regulation of neurotransmitter levels (GO:0001505)2.95052001
109male meiosis (GO:0007140)2.94674197
110cell migration involved in heart development (GO:0060973)2.94615849
111single fertilization (GO:0007338)2.94416026
112epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93004998
113urinary tract smooth muscle contraction (GO:0014848)2.92946043
114organic cation transport (GO:0015695)2.92789767
115norepinephrine metabolic process (GO:0042415)2.91728422
116nucleobase catabolic process (GO:0046113)2.91173965
117tachykinin receptor signaling pathway (GO:0007217)2.89977918
118spinal cord motor neuron differentiation (GO:0021522)2.88927403
119regulation of vesicle fusion (GO:0031338)2.88096674
120coronary vasculature morphogenesis (GO:0060977)2.87174222
121spermatid nucleus differentiation (GO:0007289)2.84781922
122peripheral nervous system neuron development (GO:0048935)2.84131870
123DNA double-strand break processing (GO:0000729)2.82821204
124innervation (GO:0060384)2.82426582
125neuron recognition (GO:0008038)2.82178834
126indolalkylamine metabolic process (GO:0006586)2.82053292
127positive regulation of cellular amide metabolic process (GO:0034250)2.82014665
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.81739750
129positive regulation of synaptic transmission, GABAergic (GO:0032230)2.81476129
130microtubule severing (GO:0051013)2.80697073
131regulation of neurotransmitter transport (GO:0051588)2.80678951
132regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.77393795
133tongue development (GO:0043586)2.77248351
134membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76739141
135reproduction (GO:0000003)2.74915266
136regulation of neuronal synaptic plasticity (GO:0048168)2.74642059
137DNA methylation involved in gamete generation (GO:0043046)2.74417358
138positive regulation of insulin secretion (GO:0032024)2.72537796
139potassium ion homeostasis (GO:0055075)2.72479612
140gamete generation (GO:0007276)2.71627954
141presynaptic membrane organization (GO:0097090)2.69162033
142regulation of neuron projection regeneration (GO:0070570)2.69142020
143regulation of axon regeneration (GO:0048679)2.69142020
144axonemal dynein complex assembly (GO:0070286)2.68312839
145glycine transport (GO:0015816)2.66684598
146sperm capacitation (GO:0048240)2.65914559
147regulation of synapse structural plasticity (GO:0051823)2.65022908
148axonal fasciculation (GO:0007413)2.64378587
149catechol-containing compound biosynthetic process (GO:0009713)2.62566933
150catecholamine biosynthetic process (GO:0042423)2.62566933
151response to pain (GO:0048265)2.62205221
152cartilage morphogenesis (GO:0060536)2.61631094
153long-term memory (GO:0007616)2.61188245
154positive regulation of cell size (GO:0045793)2.61153207
155dendrite morphogenesis (GO:0048813)2.60673340
156positive regulation of synaptic transmission (GO:0050806)2.60611408
157synaptic transmission, glutamatergic (GO:0035249)2.60034632
158neurotransmitter biosynthetic process (GO:0042136)2.59982649
159positive regulation of synapse assembly (GO:0051965)2.58698681
160positive regulation of vesicle fusion (GO:0031340)2.58337613
161insulin secretion (GO:0030073)2.58254563
162positive regulation of potassium ion transport (GO:0043268)2.57879399
163startle response (GO:0001964)2.56639839
164neuron-neuron synaptic transmission (GO:0007270)2.54267144
165regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.53795527
166DNA packaging (GO:0006323)2.53382228
167DNA integration (GO:0015074)2.52695802
168ionotropic glutamate receptor signaling pathway (GO:0035235)2.52405695
169cell communication by electrical coupling (GO:0010644)2.52357103
170regulation of meiosis I (GO:0060631)2.52243857
171microtubule nucleation (GO:0007020)2.51825896
172synaptic transmission, cholinergic (GO:0007271)2.51489157
173synapse assembly (GO:0007416)2.50268293
174retinal cone cell development (GO:0046549)2.50072875
175alanine transport (GO:0032328)2.49712193
176regulation of membrane repolarization (GO:0060306)2.49702454
177regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.49685512
178fucose catabolic process (GO:0019317)2.48988473
179L-fucose metabolic process (GO:0042354)2.48988473
180L-fucose catabolic process (GO:0042355)2.48988473
181maternal behavior (GO:0042711)2.48957168
182fertilization (GO:0009566)2.48636538
183embryonic epithelial tube formation (GO:0001838)2.48402381
184cell wall macromolecule metabolic process (GO:0044036)2.47677780
185positive regulation of action potential (GO:0045760)2.47029841
186signal release (GO:0023061)2.46978637
187regulation of insulin secretion (GO:0050796)2.46716625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.70871601
2GBX2_23144817_ChIP-Seq_PC3_Human3.58287428
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15262292
4IGF1R_20145208_ChIP-Seq_DFB_Human3.05693305
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.94910831
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.72587664
7SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.61378334
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60462173
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55452337
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51754222
11* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.45828231
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.43874361
13VDR_22108803_ChIP-Seq_LS180_Human2.42366342
14REST_21632747_ChIP-Seq_MESCs_Mouse2.42277175
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.40718110
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36027847
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.25975255
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.25975255
19EED_16625203_ChIP-ChIP_MESCs_Mouse2.20088140
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.13547532
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.09368498
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08628928
23AR_21572438_ChIP-Seq_LNCaP_Human2.08624932
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07938867
25* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06131123
26NR3C1_23031785_ChIP-Seq_PC12_Mouse2.06030016
27CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01689544
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.99627940
29PIAS1_25552417_ChIP-Seq_VCAP_Human1.98765869
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.97084710
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96754821
32IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.94470953
33CBP_20019798_ChIP-Seq_JUKART_Human1.94470953
34IKZF1_21737484_ChIP-ChIP_HCT116_Human1.91468285
35DROSHA_22980978_ChIP-Seq_HELA_Human1.82091180
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76856720
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75334837
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74787588
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74337863
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.69396893
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68712776
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68169764
43P300_19829295_ChIP-Seq_ESCs_Human1.64687707
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.61093686
45GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.58310453
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53871955
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.53834371
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.53549560
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53248225
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53248225
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.51109283
52* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.49739793
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49523174
54NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.48079122
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.47163667
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45666271
57AR_25329375_ChIP-Seq_VCAP_Human1.43614725
58FLI1_27457419_Chip-Seq_LIVER_Mouse1.43043441
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.42145863
60SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38676591
61SOX2_19829295_ChIP-Seq_ESCs_Human1.38614600
62NANOG_19829295_ChIP-Seq_ESCs_Human1.38614600
63E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38347478
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.37274127
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37180315
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.35809988
67TCF4_22108803_ChIP-Seq_LS180_Human1.35162026
68BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35124681
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.34866361
70ERG_21242973_ChIP-ChIP_JURKAT_Human1.34687492
71RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33146592
72* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32828677
73* SMAD4_21741376_ChIP-Seq_EPCs_Human1.32185665
74STAT3_23295773_ChIP-Seq_U87_Human1.29853724
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27401764
76EWS_26573619_Chip-Seq_HEK293_Human1.27397247
77ZNF274_21170338_ChIP-Seq_K562_Hela1.26483597
78PCGF2_27294783_Chip-Seq_NPCs_Mouse1.26268948
79MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24824636
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.24721858
81IRF1_19129219_ChIP-ChIP_H3396_Human1.24020386
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23786139
83NCOR_22424771_ChIP-Seq_293T_Human1.23062806
84ETV2_25802403_ChIP-Seq_MESCs_Mouse1.20977572
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20318192
86PCGF2_27294783_Chip-Seq_ESCs_Mouse1.20219681
87TCF4_23295773_ChIP-Seq_U87_Human1.19930710
88FUS_26573619_Chip-Seq_HEK293_Human1.19593725
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19428206
90TP53_22573176_ChIP-Seq_HFKS_Human1.19121947
91BCAT_22108803_ChIP-Seq_LS180_Human1.17360278
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16185307
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16021405
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15058099
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14812302
96NANOG_20526341_ChIP-Seq_ESCs_Human1.14667025
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14078925
98* TBL1_22424771_ChIP-Seq_293T_Human1.13998394
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.13730958
100OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13377847
101RUNX2_22187159_ChIP-Seq_PCA_Human1.13187712
102MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11827309
103RNF2_27304074_Chip-Seq_NSC_Mouse1.11820750
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.11401602
105AR_19668381_ChIP-Seq_PC3_Human1.11254370
106* RING1B_27294783_Chip-Seq_ESCs_Mouse1.10960361
107ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.10828150
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10567198
109WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10128518
110NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09962125
111FOXA1_25329375_ChIP-Seq_VCAP_Human1.09613799
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09613799
113* NFYB_21822215_ChIP-Seq_K562_Human1.09441853
114HOXB7_26014856_ChIP-Seq_BT474_Human1.09132583
115TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07883960
116PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07142924
117* ETV1_20927104_ChIP-Seq_GIST48_Human1.05859581
118EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05840818
119RING1B_27294783_Chip-Seq_NPCs_Mouse1.05570773
120* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05281371
121* NFE2_27457419_Chip-Seq_LIVER_Mouse1.05047393
122* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05041122
123CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04765838
124FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04323605
125* ER_23166858_ChIP-Seq_MCF-7_Human1.03627196
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02898845
127MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02537519
128LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01400883
129MYC_19829295_ChIP-Seq_ESCs_Human1.01375880
130TAF15_26573619_Chip-Seq_HEK293_Human1.00645459
131* GATA3_21878914_ChIP-Seq_MCF-7_Human0.99883926
132* CBX2_22325352_ChIP-Seq_293T-Rex_Human0.99234245
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.99183001
134* EZH2_27294783_Chip-Seq_NPCs_Mouse0.98756329
135AHR_22903824_ChIP-Seq_MCF-7_Human0.97949874
136* NANOG_18555785_Chip-Seq_ESCs_Mouse0.97313184
137* RBPJ_21746931_ChIP-Seq_IB4_Human0.97274416
138ERA_21632823_ChIP-Seq_H3396_Human0.96992967
139RAC3_21632823_ChIP-Seq_H3396_Human0.96282502
140* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96257180
141* SMAD4_21741376_ChIP-Seq_HESCs_Human0.96176206
142* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93739852
143TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93250590
144* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92467430
145PRDM14_20953172_ChIP-Seq_ESCs_Human0.92359032
146* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90420611
147CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86983303
148TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86964843
149TAL1_26923725_Chip-Seq_HPCs_Mouse0.86511864
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85403208
151CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84943557
152* E2F1_18555785_Chip-Seq_ESCs_Mouse0.84040641
153SMAD3_21741376_ChIP-Seq_HESCs_Human0.83598585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.47689960
2MP0005410_abnormal_fertilization3.83393168
3MP0002638_abnormal_pupillary_reflex3.65649283
4MP0010386_abnormal_urinary_bladder3.51196985
5MP0004859_abnormal_synaptic_plasticity3.11621418
6MP0004270_analgesia3.02739258
7MP0005670_abnormal_white_adipose2.99308820
8MP0003183_abnormal_peptide_metabolism2.80697096
9MP0009780_abnormal_chondrocyte_physiolo2.79228428
10MP0003635_abnormal_synaptic_transmissio2.59138963
11MP0002909_abnormal_adrenal_gland2.53225331
12MP0003880_abnormal_central_pattern2.47429395
13MP0009745_abnormal_behavioral_response2.46696247
14MP0002734_abnormal_mechanical_nocicepti2.45585194
15MP0004858_abnormal_nervous_system2.40058881
16MP0000013_abnormal_adipose_tissue2.38338383
17MP0008877_abnormal_DNA_methylation2.30225054
18MP0002572_abnormal_emotion/affect_behav2.27212826
19MP0005646_abnormal_pituitary_gland2.26022798
20MP0002064_seizures2.23307200
21MP0005645_abnormal_hypothalamus_physiol2.17291596
22MP0002063_abnormal_learning/memory/cond2.15721811
23MP0001529_abnormal_vocalization2.12119433
24MP0000372_irregular_coat_pigmentation2.08694522
25MP0005423_abnormal_somatic_nervous2.07548020
26MP0002733_abnormal_thermal_nociception2.00913870
27MP0003698_abnormal_male_reproductive1.95828905
28MP0006276_abnormal_autonomic_nervous1.95654642
29MP0003122_maternal_imprinting1.94296749
30MP0002272_abnormal_nervous_system1.92032038
31MP0003567_abnormal_fetal_cardiomyocyte1.91215209
32MP0001905_abnormal_dopamine_level1.87077285
33MP0001486_abnormal_startle_reflex1.79602071
34MP0001970_abnormal_pain_threshold1.75298453
35MP0002009_preneoplasia1.73930262
36MP0003172_abnormal_lysosome_physiology1.72565789
37MP0001501_abnormal_sleep_pattern1.71201168
38MP0009046_muscle_twitch1.70805869
39MP0000516_abnormal_urinary_system1.67904678
40MP0005367_renal/urinary_system_phenotyp1.67904678
41MP0001929_abnormal_gametogenesis1.65524205
42MP0001440_abnormal_grooming_behavior1.64799709
43MP0005379_endocrine/exocrine_gland_phen1.64667396
44MP0008058_abnormal_DNA_repair1.62114330
45MP0002557_abnormal_social/conspecific_i1.57367962
46MP0001502_abnormal_circadian_rhythm1.56371747
47MP0001270_distended_abdomen1.56114143
48MP0002751_abnormal_autonomic_nervous1.55784572
49MP0006072_abnormal_retinal_apoptosis1.55452048
50MP0008569_lethality_at_weaning1.51305366
51MP0000778_abnormal_nervous_system1.48390382
52MP0002184_abnormal_innervation1.47568687
53MP0004885_abnormal_endolymph1.47475870
54MP0004924_abnormal_behavior1.46946816
55MP0005386_behavior/neurological_phenoty1.46946816
56MP0001188_hyperpigmentation1.44631860
57MP0000538_abnormal_urinary_bladder1.41782221
58MP0002735_abnormal_chemical_nociception1.40925212
59MP0005083_abnormal_biliary_tract1.40847588
60MP0003329_amyloid_beta_deposits1.39005826
61MP0003787_abnormal_imprinting1.37473136
62MP0005551_abnormal_eye_electrophysiolog1.36643902
63MP0001968_abnormal_touch/_nociception1.36226185
64MP0002067_abnormal_sensory_capabilities1.35806376
65MP0003011_delayed_dark_adaptation1.34228280
66MP0000955_abnormal_spinal_cord1.32202537
67MP0001984_abnormal_olfaction1.29711764
68MP0000678_abnormal_parathyroid_gland1.28888549
69MP0003633_abnormal_nervous_system1.27878728
70MP0002102_abnormal_ear_morphology1.23834711
71MP0002882_abnormal_neuron_morphology1.23563790
72MP0002090_abnormal_vision1.18970405
73MP0003631_nervous_system_phenotype1.17757873
74MP0002876_abnormal_thyroid_physiology1.14966112
75MP0002693_abnormal_pancreas_physiology1.11829175
76MP0003878_abnormal_ear_physiology1.11784998
77MP0005377_hearing/vestibular/ear_phenot1.11784998
78MP0001986_abnormal_taste_sensitivity1.11395089
79MP0004811_abnormal_neuron_physiology1.09743367
80MP0003195_calcinosis1.09601927
81MP0008961_abnormal_basal_metabolism1.09339957
82MP0003718_maternal_effect1.08457957
83MP0000631_abnormal_neuroendocrine_gland1.08302367
84MP0002877_abnormal_melanocyte_morpholog1.08266275
85MP0008995_early_reproductive_senescence1.07772561
86MP0001944_abnormal_pancreas_morphology1.06638839
87MP0005253_abnormal_eye_physiology1.06293062
88MP0002837_dystrophic_cardiac_calcinosis1.04926584
89MP0005187_abnormal_penis_morphology1.04070525
90MP0003632_abnormal_nervous_system1.02737432
91MP0002066_abnormal_motor_capabilities/c1.02083900
92MP0005167_abnormal_blood-brain_barrier0.99897954
93MP0001348_abnormal_lacrimal_gland0.98721122
94MP0005409_darkened_coat_color0.98581031
95MP0002736_abnormal_nociception_after0.94872792
96MP0004043_abnormal_pH_regulation0.94537811
97MP0003634_abnormal_glial_cell0.94504276
98MP0003646_muscle_fatigue0.94109662
99MP0009379_abnormal_foot_pigmentation0.93549628
100MP0006292_abnormal_olfactory_placode0.92859215
101MP0004142_abnormal_muscle_tone0.92695066
102MP0000681_abnormal_thyroid_gland0.91732879
103MP0002069_abnormal_eating/drinking_beha0.90164571
104MP0002161_abnormal_fertility/fecundity0.89863793
105MP0002229_neurodegeneration0.89813434
106MP0000653_abnormal_sex_gland0.89661660
107MP0002210_abnormal_sex_determination0.89526624
108MP0008872_abnormal_physiological_respon0.89015821
109MP0000613_abnormal_salivary_gland0.88285061
110MP0000534_abnormal_ureter_morphology0.86938079
111MP0002752_abnormal_somatic_nervous0.85689846
112MP0001664_abnormal_digestion0.85213215
113MP0002152_abnormal_brain_morphology0.84634328
114MP0002163_abnormal_gland_morphology0.84148755
115MP0002078_abnormal_glucose_homeostasis0.82626163
116MP0003953_abnormal_hormone_level0.81583184
117MP0001145_abnormal_male_reproductive0.81060188
118MP0002127_abnormal_cardiovascular_syste0.80354064
119MP0000427_abnormal_hair_cycle0.79024717
120MP0003879_abnormal_hair_cell0.78830237
121MP0000003_abnormal_adipose_tissue0.78788928
122MP0002653_abnormal_ependyma_morphology0.77958556
123MP0003283_abnormal_digestive_organ0.77597907
124MP0000049_abnormal_middle_ear0.77489128
125MP0005171_absent_coat_pigmentation0.77303104
126MP0005394_taste/olfaction_phenotype0.77012449
127MP0005499_abnormal_olfactory_system0.77012449
128MP0001963_abnormal_hearing_physiology0.75996127
129MP0005535_abnormal_body_temperature0.75460728
130MP0004742_abnormal_vestibular_system0.74456036
131MP0003786_premature_aging0.73645525
132MP0005084_abnormal_gallbladder_morpholo0.72309983
133MP0004085_abnormal_heartbeat0.69554892
134MP0001299_abnormal_eye_distance/0.68882264
135MP0005365_abnormal_bile_salt0.68768125
136MP0004215_abnormal_myocardial_fiber0.67851072
137MP0004145_abnormal_muscle_electrophysio0.67613851
138MP0000647_abnormal_sebaceous_gland0.67433188

Predicted human phenotypes

RankGene SetZ-score
1Hypothermia (HP:0002045)6.03082579
2Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.01716300
3Focal motor seizures (HP:0011153)4.41061998
4Attenuation of retinal blood vessels (HP:0007843)4.20661264
5Myokymia (HP:0002411)4.09311781
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.04436802
7Abnormality of the parathyroid morphology (HP:0011766)3.95510114
8Potter facies (HP:0002009)3.93249708
9Facial shape deformation (HP:0011334)3.93249708
10Chronic hepatic failure (HP:0100626)3.91990222
11Hyperinsulinemic hypoglycemia (HP:0000825)3.68021701
12Abnormality of the phalanges of the 2nd finger (HP:0009541)3.63414155
13Hyperventilation (HP:0002883)3.63372869
14Agitation (HP:0000713)3.53347343
15Abnormality of macular pigmentation (HP:0008002)3.51851586
16Occipital encephalocele (HP:0002085)3.49292489
17Bony spicule pigmentary retinopathy (HP:0007737)3.44841079
18Orthostatic hypotension (HP:0001278)3.40986788
19Nephronophthisis (HP:0000090)3.34782784
20Pancreatic cysts (HP:0001737)3.34151015
21Pheochromocytoma (HP:0002666)3.31086885
22Intestinal atresia (HP:0011100)3.30653456
23Abnormal rod and cone electroretinograms (HP:0008323)3.23861132
24Congenital stationary night blindness (HP:0007642)3.23365555
25Progressive cerebellar ataxia (HP:0002073)3.22500068
26Visual hallucinations (HP:0002367)3.20854826
27Epileptic encephalopathy (HP:0200134)3.15123967
28Pancreatic fibrosis (HP:0100732)3.12160893
29Limb dystonia (HP:0002451)3.10078218
30Severe visual impairment (HP:0001141)3.07861868
31True hermaphroditism (HP:0010459)3.02307708
32Febrile seizures (HP:0002373)3.01955982
33Abnormal autonomic nervous system physiology (HP:0012332)3.00289530
34Action tremor (HP:0002345)3.00272274
35Tubulointerstitial nephritis (HP:0001970)2.98188533
36Symptomatic seizures (HP:0011145)2.97166571
37Abnormality of the renal medulla (HP:0100957)2.97046370
38Neurofibrillary tangles (HP:0002185)2.94890880
39Hypoglycemic seizures (HP:0002173)2.91279207
40Supranuclear gaze palsy (HP:0000605)2.88471097
41Abnormality of midbrain morphology (HP:0002418)2.87457846
42Molar tooth sign on MRI (HP:0002419)2.87457846
43Anxiety (HP:0000739)2.83023606
44Atonic seizures (HP:0010819)2.81706678
45Menstrual irregularities (HP:0000858)2.78660271
46Neuroendocrine neoplasm (HP:0100634)2.75937955
47Depression (HP:0000716)2.75053868
48Postural instability (HP:0002172)2.73537785
49Aplasia involving bones of the upper limbs (HP:0009823)2.72000017
50Aplasia of the phalanges of the hand (HP:0009802)2.72000017
51Aplasia involving bones of the extremities (HP:0009825)2.72000017
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.70437760
53Abnormality of the renal cortex (HP:0011035)2.70146844
54Focal seizures (HP:0007359)2.69860042
55Supernumerary spleens (HP:0009799)2.66905610
56Increased circulating renin level (HP:0000848)2.63424317
57Dysdiadochokinesis (HP:0002075)2.58663908
58Hyperthyroidism (HP:0000836)2.57653876
59Pendular nystagmus (HP:0012043)2.56362587
60Dynein arm defect of respiratory motile cilia (HP:0012255)2.47656543
61Absent/shortened dynein arms (HP:0200106)2.47656543
62Bicornuate uterus (HP:0000813)2.46686185
63Amblyopia (HP:0000646)2.44457156
64Blue irides (HP:0000635)2.42546464
65Hyperparathyroidism (HP:0000843)2.41502948
66Type II lissencephaly (HP:0007260)2.39525748
67Cerebral inclusion bodies (HP:0100314)2.39137056
68Megalencephaly (HP:0001355)2.37176253
69Renal dysplasia (HP:0000110)2.34944370
70Exotropia (HP:0000577)2.33905975
71Aplasia/Hypoplasia of the fovea (HP:0008060)2.33379841
72Hypoplasia of the fovea (HP:0007750)2.33379841
73Hemiparesis (HP:0001269)2.32986766
74Absence seizures (HP:0002121)2.31756537
75Genital tract atresia (HP:0001827)2.31125528
76Generalized tonic-clonic seizures (HP:0002069)2.29747707
77EEG with generalized epileptiform discharges (HP:0011198)2.25459279
78Epileptiform EEG discharges (HP:0011182)2.24361444
79Vaginal atresia (HP:0000148)2.23886425
80Hypercortisolism (HP:0001578)2.23820201
81Tubulointerstitial abnormality (HP:0001969)2.23609900
82Cystic liver disease (HP:0006706)2.21843934
83Abolished electroretinogram (ERG) (HP:0000550)2.21599144
84Hypotension (HP:0002615)2.20995315
85Retinal atrophy (HP:0001105)2.20858414
86Medial flaring of the eyebrow (HP:0010747)2.20839386
87Abnormality of the fovea (HP:0000493)2.20686196
88Drooling (HP:0002307)2.19776779
89Excessive salivation (HP:0003781)2.19776779
90Congenital sensorineural hearing impairment (HP:0008527)2.19517343
91Asplenia (HP:0001746)2.19482170
92Neonatal hypoglycemia (HP:0001998)2.19368584
93Decreased central vision (HP:0007663)2.19005597
94Abnormal respiratory motile cilium morphology (HP:0005938)2.18049565
95Abnormal respiratory epithelium morphology (HP:0012253)2.18049565
96Papilledema (HP:0001085)2.16912619
97Truncal ataxia (HP:0002078)2.16651182
98Clumsiness (HP:0002312)2.16132455
99Tubular atrophy (HP:0000092)2.16038307
100Prolonged QT interval (HP:0001657)2.14194989
101Central scotoma (HP:0000603)2.11255113
102Aplasia/Hypoplasia of the macula (HP:0008059)2.10557086
103Hypsarrhythmia (HP:0002521)2.10088156
104Abnormal eating behavior (HP:0100738)2.08987708
105Hypoventilation (HP:0002791)2.07773508
106Scotoma (HP:0000575)2.06104535
107Gaze-evoked nystagmus (HP:0000640)2.03742287
108Restlessness (HP:0000711)2.03275038
109Postural tremor (HP:0002174)2.03118574
110Polydipsia (HP:0001959)2.02437612
111Abnormal drinking behavior (HP:0030082)2.02437612
112Broad-based gait (HP:0002136)2.02387947
113Bradykinesia (HP:0002067)2.01439303
114Polyphagia (HP:0002591)2.01425925
115Dysostosis multiplex (HP:0000943)1.99689647
116Ketoacidosis (HP:0001993)1.99233491
117Dialeptic seizures (HP:0011146)1.98988624
118Failure to thrive in infancy (HP:0001531)1.97893088
119Genetic anticipation (HP:0003743)1.96103667
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.95513271
121Abnormality of dental color (HP:0011073)1.94791922
122Renal cortical cysts (HP:0000803)1.94099506
123Polyuria (HP:0000103)1.92401736
124Late onset (HP:0003584)1.87341669
125Congenital hepatic fibrosis (HP:0002612)1.86987734
126Abnormal ciliary motility (HP:0012262)1.86881342
127Large for gestational age (HP:0001520)1.86039238
128Type II diabetes mellitus (HP:0005978)1.85645383
129Impaired smooth pursuit (HP:0007772)1.85351387
130Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.85323955
131Sclerocornea (HP:0000647)1.84246971
132Goiter (HP:0000853)1.84157688
133Adrenal overactivity (HP:0002717)1.83948704
134Hypoglycemic coma (HP:0001325)1.83637996
135Impulsivity (HP:0100710)1.83184115
136Absent speech (HP:0001344)1.82248302
137Aplasia/Hypoplasia affecting the retina (HP:0008061)1.82161829
138Rigidity (HP:0002063)1.81677084
139Chorioretinal atrophy (HP:0000533)1.79912444
140Photophobia (HP:0000613)1.79403063
141Bile duct proliferation (HP:0001408)1.78530740
142Abnormal biliary tract physiology (HP:0012439)1.78530740
143Hyperphosphatemia (HP:0002905)1.77698877
144Progressive inability to walk (HP:0002505)1.77408375
145Increased corneal curvature (HP:0100692)1.77384103
146Keratoconus (HP:0000563)1.77384103
147Oligohydramnios (HP:0001562)1.77295934
148Short tibia (HP:0005736)1.76306952
149Gastrointestinal atresia (HP:0002589)1.76298577
150Hypokalemia (HP:0002900)1.76262899
151Abnormality of the epiphysis of the femoral head (HP:0010574)1.75766655
152Macroorchidism (HP:0000053)1.75702528
153Abnormality of the femoral head (HP:0003368)1.73847345
154Constricted visual fields (HP:0001133)1.73270504
155Gait imbalance (HP:0002141)1.73245082
156Anencephaly (HP:0002323)1.73076175
157Abnormal urine output (HP:0012590)1.72580557
158Gait ataxia (HP:0002066)1.72107831
159Retinal dysplasia (HP:0007973)1.71894625
160Abnormality of alanine metabolism (HP:0010916)1.71721085
161Hyperalaninemia (HP:0003348)1.71721085
162Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71721085
163Dysautonomia (HP:0002459)1.71076857
164Hypocalcemia (HP:0002901)1.70628460
165Inability to walk (HP:0002540)1.69354324
166Abnormal EKG (HP:0003115)1.68921512
167Spastic tetraplegia (HP:0002510)1.68277196
168Postaxial foot polydactyly (HP:0001830)1.67436360
169Abnormality of renin-angiotensin system (HP:0000847)1.67305675
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.67043186
171Aplasia/hypoplasia of the uterus (HP:0008684)1.66670976
172Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65392710
173Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.65298926
174Poor suck (HP:0002033)1.64611901
175Abnormality of ocular smooth pursuit (HP:0000617)1.64600167
176Aplasia/Hypoplasia of the lens (HP:0008063)1.63878351
177Dysmetria (HP:0001310)1.63760912
178Aganglionic megacolon (HP:0002251)1.63755167
179Abnormality of the aortic arch (HP:0012303)1.63739218
180Abnormality of aromatic amino acid family metabolism (HP:0004338)1.60533561
181Abnormality of salivation (HP:0100755)1.59212762

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK44.66422078
2CASK4.12374164
3WNK33.82817099
4MAP4K23.73989906
5NTRK13.70178039
6NTRK33.09471383
7CCNB13.01328398
8MAP2K72.72277510
9INSRR2.66499811
10MAP3K42.63506244
11MAPK152.60627722
12GRK72.32008341
13NTRK22.30607319
14TYRO32.12971693
15TNIK2.10882587
16MARK12.02561384
17CSNK1A1L2.01619603
18BMPR1B2.01103119
19FES2.01060196
20NUAK12.00201517
21ZAK1.90576763
22EPHA41.88773332
23UHMK11.84331995
24CSNK1G11.81034522
25BRD41.78317528
26PRKD31.78001262
27WNK41.69886992
28NEK21.68049371
29PHKG11.68013180
30PHKG21.68013180
31PRPF4B1.66894837
32MINK11.65356682
33MUSK1.64594992
34ADRBK21.61489937
35SGK4941.59941256
36SGK2231.59941256
37ACVR1B1.56662106
38TESK11.53001244
39GRK51.52894975
40SGK21.49626259
41MAPK131.34480079
42MAP2K41.34240147
43AKT31.32777701
44PLK21.30334241
45MAP3K21.30325844
46IRAK21.30192937
47GRK11.16410215
48DYRK21.14161202
49PRKCG1.13832306
50STK38L1.13002742
51PNCK1.09537327
52CDK51.09477846
53PINK11.06697193
54EIF2AK31.04019092
55HIPK21.03258807
56MATK1.03226640
57SGK30.99627164
58ERBB30.97513096
59PRKCE0.97495186
60TAF10.95307912
61DYRK30.94876847
62DAPK20.93679189
63TRIM280.92913201
64NME10.92897329
65PIK3CG0.92572043
66CAMK1G0.92258881
67PTK2B0.92224346
68TESK20.91787500
69ADRBK10.91152782
70EIF2AK10.90312415
71ERBB40.87441964
72DYRK1A0.86606060
73RET0.84927219
74CDC42BPA0.83332599
75VRK20.82015517
76CAMK1D0.79629277
77CAMK2A0.78277339
78DDR20.77501848
79PAK30.75804440
80IRAK10.75234834
81FLT30.74631981
82STK390.73504743
83PAK60.72097830
84PRKCH0.71166726
85CAMK40.70744189
86LMTK20.70728927
87SIK30.65688341
88WNK10.65106966
89CAMKK10.62917040
90BCKDK0.62457834
91PASK0.62454787
92CAMK2B0.61908431
93CSNK1G20.61376443
94SGK10.59838611
95CAMKK20.59381727
96CAMK10.58973202
97TSSK60.57995845
98CAMK2D0.57686881
99SRPK10.57299638
100ERBB20.57285090
101NEK60.57207366
102PKN10.57161496
103VRK10.55724302
104FER0.55707016
105PTK20.54465874
106TIE10.54079057
107MAP2K10.53847533
108CDK30.53721587
109FGFR20.53430410
110CDK140.52218766
111PLK30.52209447
112DYRK1B0.52029323
113PRKAA20.51208965
114PRKACA0.51197315
115TAOK30.50923425
116MAP3K90.50898513
117CSNK1G30.49297196
118OXSR10.48979212
119CAMK2G0.48891757
120CSNK1D0.46580423
121PDGFRA0.46451604
122MKNK10.45054634
123RPS6KA30.44722636
124RPS6KB10.44115788
125DAPK10.43585995
126MKNK20.43525220
127FRK0.43472319
128MAP3K120.43403962
129PRKACG0.41574598
130BMPR20.41082359
131CDK180.40784648
132PRKCI0.40697659
133PRKG10.39622511
134PDGFRB0.39616354
135STK380.38730891
136TLK10.37697252
137MAPK70.36882492
138PBK0.36763218
139CDK150.36339957
140BCR0.34819004
141ATR0.34730755
142PRKCA0.34374702
143IGF1R0.34232845
144CSNK1A10.33727818
145MAPKAPK50.32529205
146KSR10.31564523
147ATM0.31384360
148CDK11A0.31227454
149CSNK1E0.30225328

Predicted pathways (KEGG)

RankGene SetZ-score
1Insulin secretion_Homo sapiens_hsa049112.92671289
2Synaptic vesicle cycle_Homo sapiens_hsa047212.88487661
3Nitrogen metabolism_Homo sapiens_hsa009102.83192789
4Maturity onset diabetes of the young_Homo sapiens_hsa049502.75086517
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.63600817
6Cocaine addiction_Homo sapiens_hsa050302.54465173
7GABAergic synapse_Homo sapiens_hsa047272.32308760
8Cholinergic synapse_Homo sapiens_hsa047252.28535018
9Amphetamine addiction_Homo sapiens_hsa050312.25933893
10Nicotine addiction_Homo sapiens_hsa050332.24599725
11Glutamatergic synapse_Homo sapiens_hsa047242.21891227
12Circadian entrainment_Homo sapiens_hsa047132.18162150
13Dopaminergic synapse_Homo sapiens_hsa047282.16626478
14Serotonergic synapse_Homo sapiens_hsa047262.12137913
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.09431450
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.03345071
17Morphine addiction_Homo sapiens_hsa050321.86761159
18Vibrio cholerae infection_Homo sapiens_hsa051101.86001869
19Fanconi anemia pathway_Homo sapiens_hsa034601.83249758
20Collecting duct acid secretion_Homo sapiens_hsa049661.81056530
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.80512940
22Olfactory transduction_Homo sapiens_hsa047401.79345524
23Propanoate metabolism_Homo sapiens_hsa006401.71953977
24Selenocompound metabolism_Homo sapiens_hsa004501.71591595
25Non-homologous end-joining_Homo sapiens_hsa034501.63691563
26Long-term depression_Homo sapiens_hsa047301.62540717
27Sulfur metabolism_Homo sapiens_hsa009201.57176251
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54983426
29Long-term potentiation_Homo sapiens_hsa047201.54932443
30Taste transduction_Homo sapiens_hsa047421.53937104
31Linoleic acid metabolism_Homo sapiens_hsa005911.48978728
32Fatty acid biosynthesis_Homo sapiens_hsa000611.47747356
33Caffeine metabolism_Homo sapiens_hsa002321.45558663
34Salivary secretion_Homo sapiens_hsa049701.45301513
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.41711223
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.39237762
37Basal transcription factors_Homo sapiens_hsa030221.37634397
38Gastric acid secretion_Homo sapiens_hsa049711.35583382
39Protein export_Homo sapiens_hsa030601.34795838
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.34099989
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33918460
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30052229
43Renin secretion_Homo sapiens_hsa049241.28209691
44Circadian rhythm_Homo sapiens_hsa047101.27112347
45Type I diabetes mellitus_Homo sapiens_hsa049401.20834308
46Homologous recombination_Homo sapiens_hsa034401.13527491
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.13176599
48Phototransduction_Homo sapiens_hsa047441.12938997
49Type II diabetes mellitus_Homo sapiens_hsa049301.12533702
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12505693
51RNA transport_Homo sapiens_hsa030131.10424657
52Gap junction_Homo sapiens_hsa045401.08849947
53Butanoate metabolism_Homo sapiens_hsa006501.07386514
54Retinol metabolism_Homo sapiens_hsa008301.05621304
55Pancreatic secretion_Homo sapiens_hsa049721.05285480
56Primary bile acid biosynthesis_Homo sapiens_hsa001201.04573820
57RNA polymerase_Homo sapiens_hsa030201.03000971
58Oxidative phosphorylation_Homo sapiens_hsa001901.02235904
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.00775963
60Cyanoamino acid metabolism_Homo sapiens_hsa004601.00724330
61Tyrosine metabolism_Homo sapiens_hsa003500.96666840
62Calcium signaling pathway_Homo sapiens_hsa040200.96476753
63cAMP signaling pathway_Homo sapiens_hsa040240.95971263
64Thyroid hormone synthesis_Homo sapiens_hsa049180.95871367
65Phenylalanine metabolism_Homo sapiens_hsa003600.95596491
66Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95567382
67ABC transporters_Homo sapiens_hsa020100.94726125
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94369159
69GnRH signaling pathway_Homo sapiens_hsa049120.94053539
70Axon guidance_Homo sapiens_hsa043600.92742052
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91842060
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91612812
73Estrogen signaling pathway_Homo sapiens_hsa049150.90257173
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.89131067
75Oxytocin signaling pathway_Homo sapiens_hsa049210.88195353
76Peroxisome_Homo sapiens_hsa041460.87711670
77Regulation of autophagy_Homo sapiens_hsa041400.86526033
78Glucagon signaling pathway_Homo sapiens_hsa049220.86365615
79Fat digestion and absorption_Homo sapiens_hsa049750.85615522
80Glycerolipid metabolism_Homo sapiens_hsa005610.85254238
81Lysine degradation_Homo sapiens_hsa003100.85110065
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.84749265
83Prion diseases_Homo sapiens_hsa050200.81898744
84Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81370925
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80290360
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77804592
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.75822718
88Fatty acid degradation_Homo sapiens_hsa000710.75106555
89Metabolic pathways_Homo sapiens_hsa011000.74337085
90Melanogenesis_Homo sapiens_hsa049160.73809057
91Renin-angiotensin system_Homo sapiens_hsa046140.73723335
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73718465
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73153940
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73039533
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72964649
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72329621
97Alzheimers disease_Homo sapiens_hsa050100.72274686
98Parkinsons disease_Homo sapiens_hsa050120.72236660
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71597467
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71162525
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70558001
102Alcoholism_Homo sapiens_hsa050340.69798377
103Base excision repair_Homo sapiens_hsa034100.69658382
104Purine metabolism_Homo sapiens_hsa002300.69514181
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69258819
106Cardiac muscle contraction_Homo sapiens_hsa042600.69143454
107RNA degradation_Homo sapiens_hsa030180.67959358
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.66402480
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.65571255
110One carbon pool by folate_Homo sapiens_hsa006700.65221239
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65085373
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.62686025
113Chemical carcinogenesis_Homo sapiens_hsa052040.60888465
114beta-Alanine metabolism_Homo sapiens_hsa004100.60417960
115Glioma_Homo sapiens_hsa052140.60338427
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60114563
117Dorso-ventral axis formation_Homo sapiens_hsa043200.58616788
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.57340340
119mRNA surveillance pathway_Homo sapiens_hsa030150.57213884
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54050979
121Other glycan degradation_Homo sapiens_hsa005110.54013312
122Pyrimidine metabolism_Homo sapiens_hsa002400.52968268
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52811999
124Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.52798800
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52725860
126Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51524244
127Arachidonic acid metabolism_Homo sapiens_hsa005900.50785642
128Sphingolipid metabolism_Homo sapiens_hsa006000.49579813
129Ether lipid metabolism_Homo sapiens_hsa005650.49474037
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.48378835
131Fatty acid metabolism_Homo sapiens_hsa012120.48028810
132ErbB signaling pathway_Homo sapiens_hsa040120.47340322
133Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45918562
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.44262956
135Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.43510862
136Choline metabolism in cancer_Homo sapiens_hsa052310.42179225
137alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42067968
138Fructose and mannose metabolism_Homo sapiens_hsa000510.41526563
139Tryptophan metabolism_Homo sapiens_hsa003800.41075165
140Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40506856
141Histidine metabolism_Homo sapiens_hsa003400.40053552
142Ras signaling pathway_Homo sapiens_hsa040140.39569186
143Fatty acid elongation_Homo sapiens_hsa000620.38767734
144Arginine and proline metabolism_Homo sapiens_hsa003300.38504856
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38208385
146Wnt signaling pathway_Homo sapiens_hsa043100.35066261
147Huntingtons disease_Homo sapiens_hsa050160.34899281
148Bile secretion_Homo sapiens_hsa049760.34630077
149Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34115149
150Ovarian steroidogenesis_Homo sapiens_hsa049130.34079569
151Glycerophospholipid metabolism_Homo sapiens_hsa005640.33652831
152Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31756980

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