FAM166B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1progesterone metabolic process (GO:0042448)7.55465379
2cellular response to follicle-stimulating hormone stimulus (GO:0071372)7.18748371
3left/right pattern formation (GO:0060972)6.90424120
4cellular response to antibiotic (GO:0071236)6.90368736
5androgen biosynthetic process (GO:0006702)6.74811408
6negative regulation of execution phase of apoptosis (GO:1900118)6.26706281
7glucocorticoid biosynthetic process (GO:0006704)6.26650991
8C21-steroid hormone biosynthetic process (GO:0006700)6.19917108
9vitamin transmembrane transport (GO:0035461)6.15959366
10negative regulation of neurotransmitter secretion (GO:0046929)6.10068665
11central nervous system myelination (GO:0022010)6.09298978
12axon ensheathment in central nervous system (GO:0032291)6.09298978
13regulation of cilium movement (GO:0003352)6.00713278
14primary alcohol catabolic process (GO:0034310)5.87912851
15skeletal muscle contraction (GO:0003009)5.69989544
16C21-steroid hormone metabolic process (GO:0008207)5.69933230
17estrogen biosynthetic process (GO:0006703)5.51283354
18response to follicle-stimulating hormone (GO:0032354)5.35481266
19negative regulation of neurotransmitter transport (GO:0051589)5.31999532
20ethanol metabolic process (GO:0006067)5.26702072
21glucocorticoid metabolic process (GO:0008211)5.18605851
22cellular response to toxic substance (GO:0097237)5.09790682
23microtubule bundle formation (GO:0001578)5.01803959
24response to insecticide (GO:0017085)4.94968053
25sarcoplasmic reticulum calcium ion transport (GO:0070296)4.78468954
26diterpenoid biosynthetic process (GO:0016102)4.74900919
27actin-myosin filament sliding (GO:0033275)4.66853605
28muscle filament sliding (GO:0030049)4.66853605
29benzene-containing compound metabolic process (GO:0042537)4.65488822
30intraciliary transport (GO:0042073)4.46907184
31hormone biosynthetic process (GO:0042446)4.44567467
32positive regulation of action potential (GO:0045760)4.40277482
33neuron cell-cell adhesion (GO:0007158)4.33941101
34cilium organization (GO:0044782)4.29934662
35regulation of pigment cell differentiation (GO:0050932)4.29289634
36regulation of skeletal muscle contraction (GO:0014819)4.29036931
37presynaptic membrane assembly (GO:0097105)4.25577945
38limb bud formation (GO:0060174)4.22615529
39Leydig cell differentiation (GO:0033327)4.17705320
40cilium assembly (GO:0042384)4.14347780
41one-carbon compound transport (GO:0019755)4.12877585
42pyrimidine-containing compound transmembrane transport (GO:0072531)4.06740173
43ethanol oxidation (GO:0006069)4.05495359
44cellular response to gonadotropin stimulus (GO:0071371)4.04713433
45presynaptic membrane organization (GO:0097090)3.98439796
46sperm capacitation (GO:0048240)3.95782691
47cilium movement (GO:0003341)3.94408839
48actin-mediated cell contraction (GO:0070252)3.87067432
49lung epithelium development (GO:0060428)3.79485468
50androgen metabolic process (GO:0008209)3.78883888
51cytoplasmic microtubule organization (GO:0031122)3.75862443
52cellular response to cadmium ion (GO:0071276)3.69662951
53ketone biosynthetic process (GO:0042181)3.68942541
54cellular component assembly involved in morphogenesis (GO:0010927)3.65546497
55regulation of sequestering of triglyceride (GO:0010889)3.64334223
56terpenoid biosynthetic process (GO:0016114)3.61544910
57ventricular system development (GO:0021591)3.58931994
58response to xenobiotic stimulus (GO:0009410)3.58485173
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.51744391
60cerebral cortex radially oriented cell migration (GO:0021799)3.51524982
61regulation of germinal center formation (GO:0002634)3.50560277
62negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.50488253
63regulation of microtubule-based movement (GO:0060632)3.49545005
64vocalization behavior (GO:0071625)3.48157928
65microtubule-based movement (GO:0007018)3.47423995
66negative regulation of multicellular organism growth (GO:0040015)3.43873241
67transmission of nerve impulse (GO:0019226)3.43712108
68neuron recognition (GO:0008038)3.42938889
69import into cell (GO:0098657)3.41096547
70tolerance induction (GO:0002507)3.41077586
71protein localization to cilium (GO:0061512)3.40068754
72neuronal action potential propagation (GO:0019227)3.39981031
73ionotropic glutamate receptor signaling pathway (GO:0035235)3.38348902
74negative regulation of inclusion body assembly (GO:0090084)3.36881401
75striated muscle contraction (GO:0006941)3.36166587
76carnitine metabolic process (GO:0009437)3.34057012
77retina layer formation (GO:0010842)3.32907465
78negative regulation of immunoglobulin mediated immune response (GO:0002890)3.32629810
79negative regulation of B cell mediated immunity (GO:0002713)3.32629810
80skeletal muscle adaptation (GO:0043501)3.32616681
81myelination (GO:0042552)3.30076392
82mating behavior (GO:0007617)3.27974394
83organ growth (GO:0035265)3.27614842
84negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.27353648
85positive regulation of hormone biosynthetic process (GO:0046886)3.26605440
86glomerular epithelial cell development (GO:0072310)3.25827900
87negative regulation of humoral immune response (GO:0002921)3.25277188
88axon ensheathment (GO:0008366)3.24472958
89ensheathment of neurons (GO:0007272)3.24472958
90establishment of apical/basal cell polarity (GO:0035089)3.24059143
91centriole assembly (GO:0098534)3.23230400
92response to phenylpropanoid (GO:0080184)3.22722785
93postsynaptic membrane organization (GO:0001941)3.22137432
94regulation of interleukin-5 production (GO:0032674)3.21023745
95positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.19992284
96GTP biosynthetic process (GO:0006183)3.18657913
97regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18561304
98cellular response to epinephrine stimulus (GO:0071872)3.17945642
99negative regulation of T cell differentiation in thymus (GO:0033085)3.17183318
100regulation of execution phase of apoptosis (GO:1900117)3.15126484
101axonemal dynein complex assembly (GO:0070286)3.13468675
102primary alcohol metabolic process (GO:0034308)3.13317819
103forebrain neuron development (GO:0021884)3.11804959
104carnitine transmembrane transport (GO:1902603)3.10638696
105axoneme assembly (GO:0035082)3.09301018
106astrocyte development (GO:0014002)3.09072573
107L-amino acid import (GO:0043092)3.08884033
108retinoic acid metabolic process (GO:0042573)3.08860642
109protein localization to synapse (GO:0035418)3.08404337
110short-term memory (GO:0007614)3.04484489
111glutamate receptor signaling pathway (GO:0007215)3.03569776
112toxin metabolic process (GO:0009404)3.01493584
113regulation of relaxation of muscle (GO:1901077)3.00496647
114cell projection assembly (GO:0030031)2.99139930
115cellular response to growth hormone stimulus (GO:0071378)2.97475615
116actin filament-based movement (GO:0030048)2.96162413
117epithelial cilium movement (GO:0003351)2.94816498
118negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94367640
119retinol metabolic process (GO:0042572)2.91428155
120cerebellar granule cell differentiation (GO:0021707)2.89207417
121gamma-aminobutyric acid signaling pathway (GO:0007214)2.87380979
122positive regulation of synapse assembly (GO:0051965)2.86865682
123response to epinephrine (GO:0071871)2.85424975
124cilium morphogenesis (GO:0060271)2.85385012
125glutathione derivative biosynthetic process (GO:1901687)2.84626858
126glutathione derivative metabolic process (GO:1901685)2.84626858
127positive regulation of tolerance induction (GO:0002645)2.83629514
128exogenous drug catabolic process (GO:0042738)2.82547701
129establishment of monopolar cell polarity (GO:0061162)2.81172401
130establishment or maintenance of monopolar cell polarity (GO:0061339)2.81172401
131carnitine transport (GO:0015879)2.79850042
132amino-acid betaine transport (GO:0015838)2.79850042
133positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.79548391
134amino acid import (GO:0043090)2.78927659
135oligodendrocyte differentiation (GO:0048709)2.76791357
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75945305
137establishment of mitochondrion localization (GO:0051654)2.75262131
138regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.74801273
139response to acidic pH (GO:0010447)2.74518975
140response to muscle activity (GO:0014850)2.74237058
141positive regulation of protein kinase C signaling (GO:0090037)2.72369575
142regulation of interleukin-13 production (GO:0032656)2.72260402
143positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.69076198
144regulation of microtubule depolymerization (GO:0031114)2.68616241
145eye photoreceptor cell differentiation (GO:0001754)2.68575118
146photoreceptor cell differentiation (GO:0046530)2.68575118
147axonal fasciculation (GO:0007413)2.68499145
148regulation of glutamate receptor signaling pathway (GO:1900449)2.68367746
149nucleoside diphosphate phosphorylation (GO:0006165)2.66399344
150regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65859014
151pyrimidine nucleobase catabolic process (GO:0006208)2.63888702
152negative regulation of synaptic transmission (GO:0050805)2.63735594
153adult walking behavior (GO:0007628)2.62640045
154regulation of clathrin-mediated endocytosis (GO:2000369)2.62614382
155regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62268627
156dendritic spine morphogenesis (GO:0060997)2.61519107
157cilium or flagellum-dependent cell motility (GO:0001539)2.59330009
158neuron remodeling (GO:0016322)2.58919162
159membrane assembly (GO:0071709)2.57296809
160UTP biosynthetic process (GO:0006228)2.55869881
161spinal cord motor neuron differentiation (GO:0021522)2.54193973
162regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53055976
163response to methylmercury (GO:0051597)2.52094563
164regulation of synapse assembly (GO:0051963)2.51523608
165myelination in peripheral nervous system (GO:0022011)2.50841287
166peripheral nervous system axon ensheathment (GO:0032292)2.50841287
167glycine transport (GO:0015816)2.50237701
168gamma-aminobutyric acid transport (GO:0015812)2.49264522
169oligosaccharide biosynthetic process (GO:0009312)2.47791129
170substrate-independent telencephalic tangential migration (GO:0021826)2.47400494
171substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.47400494
172CTP biosynthetic process (GO:0006241)2.47392509
173CTP metabolic process (GO:0046036)2.47392509
174positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.47291787
175long-chain fatty acid biosynthetic process (GO:0042759)2.47080468
176synapse assembly (GO:0007416)2.46934562
177respiratory electron transport chain (GO:0022904)2.46924370
178negative regulation of astrocyte differentiation (GO:0048712)2.46568088
179positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.46350543
180electron transport chain (GO:0022900)2.45290704
181left/right axis specification (GO:0070986)2.44411350
182cerebral cortex cell migration (GO:0021795)2.43990108
183forebrain neuron differentiation (GO:0021879)2.43696525
184neurotransmitter catabolic process (GO:0042135)2.43466258
185inner mitochondrial membrane organization (GO:0007007)2.42458806
186cellular response to pH (GO:0071467)2.41039579
187regulation of synaptic transmission, GABAergic (GO:0032228)2.40846381
188membrane hyperpolarization (GO:0060081)2.39943043
189lateral sprouting from an epithelium (GO:0060601)2.39390107
190synaptic transmission, glutamatergic (GO:0035249)2.39347229
191G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39267311
192motile cilium assembly (GO:0044458)11.7364202
193epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.8622610

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.16233996
2GBX2_23144817_ChIP-Seq_PC3_Human3.75181760
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.56985122
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.44156765
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.27999797
6ESR1_20079471_ChIP-ChIP_T-47D_Human3.14476917
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.03294978
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.77329286
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.74181380
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71929982
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.57193381
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.51294324
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.48778825
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.48778825
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40820167
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36932191
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.36658031
18VDR_22108803_ChIP-Seq_LS180_Human2.36292942
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.34504919
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32389867
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27989627
22TRIM28_21343339_ChIP-Seq_HEK293_Human2.21888937
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.20403902
24TAF15_26573619_Chip-Seq_HEK293_Human2.18388027
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.15963274
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.15672314
27PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse2.12751258
28CBX2_27304074_Chip-Seq_ESCs_Mouse2.08303822
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.06641372
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.04742862
31AR_21572438_ChIP-Seq_LNCaP_Human2.03429317
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99661019
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.94127775
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91677827
35PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.90106893
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.89126671
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87177980
38TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.86185467
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.84861838
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.82204450
41ESR1_21235772_ChIP-Seq_MCF-7_Human1.78242596
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78081466
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.76827536
44REST_21632747_ChIP-Seq_MESCs_Mouse1.71508928
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67686991
46STAT1_20625510_ChIP-Seq_HELA_Human1.65658569
47SMC4_20622854_ChIP-Seq_HELA_Human1.65190536
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.62371478
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.61488074
50P300_19829295_ChIP-Seq_ESCs_Human1.61040151
51SMAD4_21799915_ChIP-Seq_A2780_Human1.58213590
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.57834231
53TBX20_22080862_ChIP-Seq_HEART_Mouse1.56493005
54TBX20_22328084_ChIP-Seq_HEART_Mouse1.56493005
55POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55517355
56RNF2_27304074_Chip-Seq_NSC_Mouse1.53508167
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53336377
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53156064
59FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.52885411
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49464349
61HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48995156
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48489744
63RUNX1_27514584_Chip-Seq_MCF-7_Human1.48068512
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.47458161
65ER_23166858_ChIP-Seq_MCF-7_Human1.46151014
66DROSHA_22980978_ChIP-Seq_HELA_Human1.44252406
67CTCF_27219007_Chip-Seq_Bcells_Human1.43219674
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42130427
69SOX2_27498859_Chip-Seq_STOMACH_Mouse1.41591792
70SRY_22984422_ChIP-ChIP_TESTIS_Rat1.41567077
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41516297
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39195588
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.39028441
74AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.37732317
75TP63_22573176_ChIP-Seq_HFKS_Human1.37606162
76FUS_26573619_Chip-Seq_HEK293_Human1.36821008
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.36594776
78TP53_18474530_ChIP-ChIP_U2OS_Human1.34832913
79ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32092081
80FOXM1_26456572_ChIP-Seq_MCF-7_Human1.31290874
81TP53_16413492_ChIP-PET_HCT116_Human1.30314130
82CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29459786
83CLOCK_20551151_ChIP-Seq_293T_Human1.29253912
84IGF1R_20145208_ChIP-Seq_DFB_Human1.29157183
85TP63_17297297_ChIP-ChIP_HaCaT_Human1.28906821
86* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.28708052
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28537342
88SMAD_19615063_ChIP-ChIP_OVARY_Human1.27278351
89GATA1_19941826_ChIP-Seq_K562_Human1.26895422
90P63_26484246_Chip-Seq_KERATINOCYTES_Human1.26682999
91* LXR_22158963_ChIP-Seq_LIVER_Mouse1.24789055
92TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24603278
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.24392626
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23800993
95NANOG_18555785_Chip-Seq_ESCs_Mouse1.22547318
96ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22546962
97RING1B_27294783_Chip-Seq_NPCs_Mouse1.20634411
98TP63_23658742_ChIP-Seq_EP156T_Human1.19649913
99UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19473548
100KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.18820655
101AHR_22903824_ChIP-Seq_MCF-7_Human1.17685351
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16236778
103AR_25329375_ChIP-Seq_VCAP_Human1.15478584
104TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15049291
105REST_18959480_ChIP-ChIP_MESCs_Mouse1.14643554
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14439745
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.13333674
108ZNF263_19887448_ChIP-Seq_K562_Human1.13098884
109STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12357763
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10636869
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10601543
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10165173
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.10064316
114CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.09720096
115NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08659302
116STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08574855
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.08470876
118RUNX2_22187159_ChIP-Seq_PCA_Human1.08220562
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07497076
120FOXA2_19822575_ChIP-Seq_HepG2_Human1.07358919
121SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07356159
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07045253
123MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.05559179
124ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04799897
125ETV1_20927104_ChIP-Seq_GIST48_Human1.04654620
126TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04430976
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04348056
128STAT3_23295773_ChIP-Seq_U87_Human1.04332162
129P68_20966046_ChIP-Seq_HELA_Human1.04199036
130* RXR_22158963_ChIP-Seq_LIVER_Mouse1.04068616
131ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03659676
132PHF8_20622853_ChIP-Seq_HELA_Human1.02742471
133RARB_27405468_Chip-Seq_BRAIN_Mouse1.02561175
134FOXA1_25552417_ChIP-Seq_VCAP_Human1.02318175
135TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02170139
136POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02170139
137HNFA_21074721_ChIP-Seq_CACO-2_Human1.01415091
138E2F1_18555785_Chip-Seq_ESCs_Mouse1.01291953
139SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01117318
140NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00825828
141SMAD3_21741376_ChIP-Seq_HESCs_Human1.00283228
142P53_22387025_ChIP-Seq_ESCs_Mouse0.99167996
143KDM2B_26808549_Chip-Seq_REH_Human0.99166140
144CMYC_18555785_Chip-Seq_ESCs_Mouse0.98805067
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98496989
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98386338
147SMRT_27268052_Chip-Seq_Bcells_Human0.97729607
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.97448951
149E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.97047151
150PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.96443014
151PRDM14_20953172_ChIP-Seq_ESCs_Human0.95770709
152SOX2_21211035_ChIP-Seq_LN229_Gbm0.95746900
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95735840
154TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95587927
155SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95081391
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.94994988
157CDX2_20551321_ChIP-Seq_CACO-2_Human0.94783161
158JUN_21703547_ChIP-Seq_K562_Human0.94733422
159RACK7_27058665_Chip-Seq_MCF-7_Human0.94689878
160KLF5_25053715_ChIP-Seq_YYC3_Human0.94653423
161FLI1_27457419_Chip-Seq_LIVER_Mouse0.94078301
162TCF4_23295773_ChIP-Seq_U87_Human0.93544669
163CREB1_26743006_Chip-Seq_LNCaP_Human0.93213029
164ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93184242
165LXR_22292898_ChIP-Seq_THP-1_Human0.93133513
166EP300_21415370_ChIP-Seq_HL-1_Mouse0.93093780
167SOX2_20726797_ChIP-Seq_SW620_Human0.93073765
168CEBPB_22108803_ChIP-Seq_LS180_Human0.93023053
169CBP_21632823_ChIP-Seq_H3396_Human0.91989875
170FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91555430
171STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91453060
172SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91130552
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.90710796
174EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90624664
175GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90048527
176ELF1_20517297_ChIP-Seq_JURKAT_Human0.89962018
177GATA6_21074721_ChIP-Seq_CACO-2_Human0.89885552
178MYC_27129775_Chip-Seq_CORNEA_Mouse0.88892478
179GATA2_19941826_ChIP-Seq_K562_Human0.85979531
180PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85754790
181NFYA_21822215_ChIP-Seq_K562_Human0.85549714
182NFYB_21822215_ChIP-Seq_K562_Human0.83863650
183CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.83461894
184CBX2_22325352_ChIP-Seq_293T-Rex_Human0.83431146
185RBPJ_21746931_ChIP-Seq_IB4_Human0.82729160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.14205530
2MP0004145_abnormal_muscle_electrophysio4.75794313
3MP0003880_abnormal_central_pattern4.08009107
4MP0002653_abnormal_ependyma_morphology3.92452684
5MP0002909_abnormal_adrenal_gland3.44214838
6MP0002132_abnormal_respiratory_system3.28396455
7MP0004859_abnormal_synaptic_plasticity3.19905045
8MP0000749_muscle_degeneration3.05963750
9MP0001984_abnormal_olfaction2.99083980
10MP0005083_abnormal_biliary_tract2.82834231
11MP0001486_abnormal_startle_reflex2.80812699
12MP0003941_abnormal_skin_development2.78774185
13MP0004742_abnormal_vestibular_system2.68930200
14MP0009046_muscle_twitch2.55968603
15MP0001346_abnormal_lacrimal_gland2.53961064
16MP0004036_abnormal_muscle_relaxation2.48034695
17MP0003136_yellow_coat_color2.41422492
18MP0003690_abnormal_glial_cell2.40967705
19MP0000747_muscle_weakness2.40831870
20MP0002277_abnormal_respiratory_mucosa2.37019874
21MP0003635_abnormal_synaptic_transmissio2.36807448
22MP0000639_abnormal_adrenal_gland2.36592135
23MP0009745_abnormal_behavioral_response2.34606722
24MP0002064_seizures2.33413434
25MP0005423_abnormal_somatic_nervous2.28791388
26MP0004270_analgesia2.22957617
27MP0010368_abnormal_lymphatic_system2.19303344
28MP0002269_muscular_atrophy2.16832574
29MP0000778_abnormal_nervous_system2.15260394
30MP0001188_hyperpigmentation2.14894074
31MP0008995_early_reproductive_senescence2.12204610
32MP0000920_abnormal_myelination2.09836040
33MP0002106_abnormal_muscle_physiology2.07889152
34MP0002272_abnormal_nervous_system2.06632603
35MP0001727_abnormal_embryo_implantation2.06596039
36MP0001765_abnormal_ion_homeostasis1.97696398
37MP0002102_abnormal_ear_morphology1.97189674
38MP0002638_abnormal_pupillary_reflex1.94800237
39MP0004087_abnormal_muscle_fiber1.94349825
40MP0008789_abnormal_olfactory_epithelium1.93857088
41MP0000759_abnormal_skeletal_muscle1.92313532
42MP0001440_abnormal_grooming_behavior1.92066539
43MP0004142_abnormal_muscle_tone1.88930402
44MP0005409_darkened_coat_color1.85697084
45MP0002063_abnormal_learning/memory/cond1.81363401
46MP0005369_muscle_phenotype1.80579243
47MP0009250_abnormal_appendicular_skeleto1.75782962
48MP0004133_heterotaxia1.75187785
49MP0003195_calcinosis1.73628536
50MP0006292_abnormal_olfactory_placode1.73365832
51MP0005451_abnormal_body_composition1.72178502
52MP0002572_abnormal_emotion/affect_behav1.70322137
53MP0005248_abnormal_Harderian_gland1.69669367
54MP0001968_abnormal_touch/_nociception1.65239177
55MP0002067_abnormal_sensory_capabilities1.63527161
56MP0002822_catalepsy1.61703456
57MP0006276_abnormal_autonomic_nervous1.61360489
58MP0006036_abnormal_mitochondrial_physio1.58193175
59MP0002971_abnormal_brown_adipose1.57560815
60MP0000026_abnormal_inner_ear1.56466415
61MP0005620_abnormal_muscle_contractility1.52963652
62MP0000013_abnormal_adipose_tissue1.52036695
63MP0002160_abnormal_reproductive_system1.51594876
64MP0005330_cardiomyopathy1.49169783
65MP0005623_abnormal_meninges_morphology1.49072226
66MP0002184_abnormal_innervation1.46151357
67MP0003011_delayed_dark_adaptation1.46013368
68MP0004043_abnormal_pH_regulation1.45524974
69MP0002734_abnormal_mechanical_nocicepti1.44057103
70MP0003950_abnormal_plasma_membrane1.42750196
71MP0001501_abnormal_sleep_pattern1.42068113
72MP0003646_muscle_fatigue1.41693097
73MP0004885_abnormal_endolymph1.40839897
74MP0001963_abnormal_hearing_physiology1.40519987
75MP0002882_abnormal_neuron_morphology1.39705297
76MP0002108_abnormal_muscle_morphology1.37696391
77MP0003938_abnormal_ear_development1.37226182
78MP0005636_abnormal_mineral_homeostasis1.35995083
79MP0003634_abnormal_glial_cell1.34839275
80MP0005551_abnormal_eye_electrophysiolog1.34516560
81MP0000733_abnormal_muscle_development1.33123407
82MP0003656_abnormal_erythrocyte_physiolo1.32743353
83MP0000750_abnormal_muscle_regeneration1.32030039
84MP0001485_abnormal_pinna_reflex1.31373416
85MP0002557_abnormal_social/conspecific_i1.30778893
86MP0001905_abnormal_dopamine_level1.30037798
87MP0005535_abnormal_body_temperature1.29712308
88MP0002752_abnormal_somatic_nervous1.28669732
89MP0002229_neurodegeneration1.27907790
90MP0004084_abnormal_cardiac_muscle1.27359336
91MP0009379_abnormal_foot_pigmentation1.26954801
92MP0000566_synostosis1.23350481
93MP0005187_abnormal_penis_morphology1.22668576
94MP0001661_extended_life_span1.22346525
95MP0002066_abnormal_motor_capabilities/c1.21468030
96MP0004019_abnormal_vitamin_homeostasis1.19576636
97MP0000955_abnormal_spinal_cord1.18671191
98MP0003329_amyloid_beta_deposits1.15679249
99MP0002972_abnormal_cardiac_muscle1.15475859
100MP0004233_abnormal_muscle_weight1.15320188
101MP0005645_abnormal_hypothalamus_physiol1.14943610
102MP0004924_abnormal_behavior1.13851685
103MP0005386_behavior/neurological_phenoty1.13851685
104MP0002736_abnormal_nociception_after1.09855185
105MP0002249_abnormal_larynx_morphology1.09603598
106MP0003137_abnormal_impulse_conducting1.09139882
107MP0009840_abnormal_foam_cell1.08767553
108MP0001879_abnormal_lymphatic_vessel1.07773455
109MP0000678_abnormal_parathyroid_gland1.07419620
110MP0004381_abnormal_hair_follicle1.06835957
111MP0002168_other_aberrant_phenotype1.06201309
112MP0004130_abnormal_muscle_cell1.05670325
113MP0002282_abnormal_trachea_morphology1.05582099
114MP0000751_myopathy1.01565019
115MP0001970_abnormal_pain_threshold1.00541409
116MP0002152_abnormal_brain_morphology0.99516471
117MP0008569_lethality_at_weaning0.98292840
118MP0005646_abnormal_pituitary_gland0.98147688
119MP0002733_abnormal_thermal_nociception0.96570067
120MP0003937_abnormal_limbs/digits/tail_de0.95969854
121MP0001851_eye_inflammation0.93357534
122MP0000631_abnormal_neuroendocrine_gland0.92301117
123MP0002735_abnormal_chemical_nociception0.91436385
124MP0004215_abnormal_myocardial_fiber0.90108822
125MP0003724_increased_susceptibility_to0.85930308
126MP0005499_abnormal_olfactory_system0.85455271
127MP0005394_taste/olfaction_phenotype0.85455271
128MP0005195_abnormal_posterior_eye0.84721655
129MP0003633_abnormal_nervous_system0.83384799
130MP0000383_abnormal_hair_follicle0.83265761
131MP0006138_congestive_heart_failure0.81901475
132MP0005165_increased_susceptibility_to0.81401788
133MP0004811_abnormal_neuron_physiology0.80549936
134MP0010234_abnormal_vibrissa_follicle0.79614255
135MP0010678_abnormal_skin_adnexa0.79248253
136MP0003631_nervous_system_phenotype0.78901051
137MP0010030_abnormal_orbit_morphology0.77837210
138MP0001177_atelectasis0.77529325
139MP0006072_abnormal_retinal_apoptosis0.76389839
140MP0010630_abnormal_cardiac_muscle0.75274789
141MP0002332_abnormal_exercise_endurance0.74149705
142MP0000462_abnormal_digestive_system0.72983305
143MP0002127_abnormal_cardiovascular_syste0.72105704
144MP0005595_abnormal_vascular_smooth0.71782996
145MP0005379_endocrine/exocrine_gland_phen0.71601688
146MP0001299_abnormal_eye_distance/0.71027526
147MP0002837_dystrophic_cardiac_calcinosis0.71027502
148MP0005253_abnormal_eye_physiology0.70934620
149MP0003632_abnormal_nervous_system0.70866384
150MP0004085_abnormal_heartbeat0.70839463
151MP0004134_abnormal_chest_morphology0.70230835
152MP0003755_abnormal_palate_morphology0.69915828
153MP0003122_maternal_imprinting0.69379052
154MP0000049_abnormal_middle_ear0.68525736
155MP0008872_abnormal_physiological_respon0.68034797
156MP0004484_altered_response_of0.67700018
157MP0001529_abnormal_vocalization0.67275535
158MP0005377_hearing/vestibular/ear_phenot0.65740046
159MP0003878_abnormal_ear_physiology0.65740046
160MP0009780_abnormal_chondrocyte_physiolo0.65379995
161MP0005266_abnormal_metabolism0.64405247
162MP0002876_abnormal_thyroid_physiology0.60894140
163MP0005385_cardiovascular_system_phenoty0.59640874
164MP0001544_abnormal_cardiovascular_syste0.59640874
165MP0005365_abnormal_bile_salt0.56980157
166MP0003953_abnormal_hormone_level0.56668348
167MP0009703_decreased_birth_body0.56241570
168MP0004883_abnormal_blood_vessel0.53876571
169MP0002896_abnormal_bone_mineralization0.51845875
170MP0009643_abnormal_urine_homeostasis0.51080105
171MP0002078_abnormal_glucose_homeostasis0.50546542
172MP0005395_other_phenotype0.49258415
173MP0005319_abnormal_enzyme/_coenzyme0.47815712
174MP0001929_abnormal_gametogenesis0.46825262
175MP0001849_ear_inflammation0.46345356
176MP0002118_abnormal_lipid_homeostasis0.44847026
177MP0000266_abnormal_heart_morphology0.44003157

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)6.88289474
2Bronchiectasis (HP:0002110)6.38211720
3Nasal polyposis (HP:0100582)5.98967093
4Degeneration of the lateral corticospinal tracts (HP:0002314)5.61983500
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.61983500
6Abnormal ciliary motility (HP:0012262)5.33961980
7Abnormal respiratory motile cilium physiology (HP:0012261)4.98406788
8Abnormality of the nasal mucosa (HP:0000433)4.98085745
9Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.76763786
10Renal salt wasting (HP:0000127)4.63645746
11Dynein arm defect of respiratory motile cilia (HP:0012255)4.62737175
12Absent/shortened dynein arms (HP:0200106)4.62737175
13Muscle fiber inclusion bodies (HP:0100299)4.53463297
14Nemaline bodies (HP:0003798)4.36963933
15Abnormality of the corticospinal tract (HP:0002492)4.32934265
16Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.23746248
17Abnormal respiratory motile cilium morphology (HP:0005938)4.16913238
18Abnormal respiratory epithelium morphology (HP:0012253)4.16913238
19Focal motor seizures (HP:0011153)4.01806277
20Exercise-induced myalgia (HP:0003738)3.97961502
21Termporal pattern (HP:0011008)3.85669100
22Insidious onset (HP:0003587)3.85669100
23Recurrent sinusitis (HP:0011108)3.79645993
24Infertility (HP:0000789)3.71888110
25Partial duplication of thumb phalanx (HP:0009944)3.71127677
26Bronchitis (HP:0012387)3.66658068
27Recurrent otitis media (HP:0000403)3.36239944
28Partial duplication of the phalanx of hand (HP:0009999)3.35336729
29Neurofibrillary tangles (HP:0002185)3.32263950
30Chronic sinusitis (HP:0011109)3.28069004
31Type 1 muscle fiber predominance (HP:0003803)3.27218775
32Hyperventilation (HP:0002883)3.21446305
33Abnormal sex determination (HP:0012244)3.20736303
34Sex reversal (HP:0012245)3.20736303
35Alacrima (HP:0000522)3.13277281
36Rhinitis (HP:0012384)3.12015134
37Muscle fiber splitting (HP:0003555)3.00673949
38Bronchomalacia (HP:0002780)3.00531006
39Hyperaldosteronism (HP:0000859)2.99581476
40Occipital encephalocele (HP:0002085)2.89955251
41Decreased circulating renin level (HP:0003351)2.86448964
42Focal seizures (HP:0007359)2.84049936
43Synostosis involving the elbow (HP:0003938)2.78732618
44Humeroradial synostosis (HP:0003041)2.78732618
45Exercise-induced muscle cramps (HP:0003710)2.78593703
46Decreased lacrimation (HP:0000633)2.78399264
47Pancreatic fibrosis (HP:0100732)2.62944793
48Duplication of thumb phalanx (HP:0009942)2.57586648
49Aplasia involving bones of the extremities (HP:0009825)2.54310661
50Aplasia involving bones of the upper limbs (HP:0009823)2.54310661
51Aplasia of the phalanges of the hand (HP:0009802)2.54310661
52Muscle hypertrophy of the lower extremities (HP:0008968)2.53662202
53True hermaphroditism (HP:0010459)2.53105017
54Submucous cleft hard palate (HP:0000176)2.51247927
55Hyperkalemia (HP:0002153)2.51060801
56Hyperactive renin-angiotensin system (HP:0000841)2.51059226
57Spastic gait (HP:0002064)2.50846217
58Urinary bladder sphincter dysfunction (HP:0002839)2.48879058
59Cerebral inclusion bodies (HP:0100314)2.48820389
60Myopathic facies (HP:0002058)2.45379219
61Genetic anticipation (HP:0003743)2.44306863
62Thickened helices (HP:0000391)2.40461659
63Agitation (HP:0000713)2.38066219
64Distal arthrogryposis (HP:0005684)2.36933603
65Septo-optic dysplasia (HP:0100842)2.33431213
66Abnormality of the calf musculature (HP:0001430)2.31056786
67Split foot (HP:0001839)2.29901288
68Ulnar deviation of the wrist (HP:0003049)2.27163216
69Chronic otitis media (HP:0000389)2.27129160
70Broad-based gait (HP:0002136)2.25170875
71Apathy (HP:0000741)2.24151237
72Epileptic encephalopathy (HP:0200134)2.23815366
73Dialeptic seizures (HP:0011146)2.23673656
74Abnormality of macular pigmentation (HP:0008002)2.21124754
75Nasolacrimal duct obstruction (HP:0000579)2.20608743
76Clumsiness (HP:0002312)2.19405955
77Tubulointerstitial nephritis (HP:0001970)2.19374476
78Male pseudohermaphroditism (HP:0000037)2.19366911
79Distal lower limb muscle weakness (HP:0009053)2.19081606
80Generalized tonic-clonic seizures (HP:0002069)2.17559999
81Calf muscle hypertrophy (HP:0008981)2.14150018
82Nephronophthisis (HP:0000090)2.13764086
83Hypokalemic alkalosis (HP:0001949)2.11663312
84Rhabdomyolysis (HP:0003201)2.10845576
85Myoglobinuria (HP:0002913)2.10750141
86Fetal akinesia sequence (HP:0001989)2.09690532
87Cystic liver disease (HP:0006706)2.09359394
88Optic nerve hypoplasia (HP:0000609)2.06645741
89Abnormality of midbrain morphology (HP:0002418)2.06573293
90Molar tooth sign on MRI (HP:0002419)2.06573293
91Bell-shaped thorax (HP:0001591)2.04695099
92Atonic seizures (HP:0010819)2.04080351
93Bowel incontinence (HP:0002607)2.03423899
94Overfolded helix (HP:0000396)2.00836826
95EMG: myopathic abnormalities (HP:0003458)2.00217901
96Chronic hepatic failure (HP:0100626)1.99050843
97Atelectasis (HP:0100750)1.98668371
98Absent septum pellucidum (HP:0001331)1.98630555
99Round ear (HP:0100830)1.97595359
100Absence seizures (HP:0002121)1.97084590
101Megalencephaly (HP:0001355)1.96966863
102Sensory axonal neuropathy (HP:0003390)1.95897824
103Pancreatic cysts (HP:0001737)1.95198911
104Concave nail (HP:0001598)1.94673670
105Restlessness (HP:0000711)1.92728282
106Diminished motivation (HP:0000745)1.92377674
107Mixed hearing impairment (HP:0000410)1.92176332
108Acute necrotizing encephalopathy (HP:0006965)1.91521348
109Optic disc pallor (HP:0000543)1.91072379
110Excessive salivation (HP:0003781)1.90982251
111Drooling (HP:0002307)1.90982251
112Supranuclear gaze palsy (HP:0000605)1.90794931
113Morphological abnormality of the pyramidal tract (HP:0002062)1.89156737
114Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87992595
115Abnormal large intestine physiology (HP:0012700)1.87542129
116Esotropia (HP:0000565)1.87166765
117Impaired vibration sensation in the lower limbs (HP:0002166)1.87135023
118Hemiparesis (HP:0001269)1.86110465
119Recurrent corneal erosions (HP:0000495)1.85975139
120Femoral bowing (HP:0002980)1.84830326
121Peripheral hypomyelination (HP:0007182)1.84112563
122Postaxial foot polydactyly (HP:0001830)1.83991051
123Cone-rod dystrophy (HP:0000548)1.83537412
124Hyperthyroidism (HP:0000836)1.82311340
125Limb-girdle muscle atrophy (HP:0003797)1.81911419
126Centrally nucleated skeletal muscle fibers (HP:0003687)1.80528866
127Rimmed vacuoles (HP:0003805)1.79878871
128Hypoplastic left heart (HP:0004383)1.78900433
129Progressive cerebellar ataxia (HP:0002073)1.78361292
130Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77244191
131Dysmetria (HP:0001310)1.77036037
132Progressive macrocephaly (HP:0004481)1.76505752
133Neck muscle weakness (HP:0000467)1.75279674
134Abnormality of the septum pellucidum (HP:0007375)1.73368961
135Asymmetric septal hypertrophy (HP:0001670)1.72803523
136Progressive inability to walk (HP:0002505)1.72695210
137Abnormality of the labia minora (HP:0012880)1.71926512
138Popliteal pterygium (HP:0009756)1.71774064
139Truncal ataxia (HP:0002078)1.71373271
140Myokymia (HP:0002411)1.71349624
141Abnormally folded helix (HP:0008544)1.70872536
142Supernumerary spleens (HP:0009799)1.70013181
143Anomalous pulmonary venous return (HP:0010772)1.69541200
144Congenital hepatic fibrosis (HP:0002612)1.69398763
145Absent speech (HP:0001344)1.68657997
146Abnormality of the pulmonary veins (HP:0011718)1.68396123
147Hyporeflexia of lower limbs (HP:0002600)1.66591550
148Abnormality of renin-angiotensin system (HP:0000847)1.66382405
149Psychosis (HP:0000709)1.65613475
150Male infertility (HP:0003251)1.65274915
151Hypoplasia of the iris (HP:0007676)1.64634337
152Coronal craniosynostosis (HP:0004440)1.64138725
153Adrenal overactivity (HP:0002717)1.63761885
154Retinal dysplasia (HP:0007973)1.63308278
155Abnormality of salivation (HP:0100755)1.61675771
156Parakeratosis (HP:0001036)1.61222222
157Visual hallucinations (HP:0002367)1.60889362
158Aplasia of the musculature (HP:0100854)1.60351405
159Abnormality of the renal medulla (HP:0100957)1.57968251
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.53887937
161Abnormality of skeletal muscle fiber size (HP:0012084)1.50329807
162Recurrent bronchitis (HP:0002837)1.45536476
163Hyponatremia (HP:0002902)1.45450482
164Muscle stiffness (HP:0003552)1.45184005
165Anencephaly (HP:0002323)1.43479420
166Medial flaring of the eyebrow (HP:0010747)1.43041847
167Difficulty running (HP:0009046)1.41456845
168Hip contracture (HP:0003273)1.40050774
169Calcaneovalgus deformity (HP:0001848)1.37370850
170Gait imbalance (HP:0002141)1.35636052
171Abnormality of the left ventricular outflow tract (HP:0011103)1.35086596
172Subaortic stenosis (HP:0001682)1.35086596
173Nonprogressive disorder (HP:0003680)1.34856379
174Sudden death (HP:0001699)1.34349782
175Absent frontal sinuses (HP:0002688)1.33786590
176Malignant hyperthermia (HP:0002047)1.33541822
177Congenital primary aphakia (HP:0007707)1.33163028
178Increased connective tissue (HP:0009025)1.31079101
179Vaginal atresia (HP:0000148)1.30711485
180Short thorax (HP:0010306)1.29957935
181Proximal amyotrophy (HP:0007126)1.29126997
182Myotonia (HP:0002486)1.27291790
183Genital tract atresia (HP:0001827)1.26951464
184Ventricular fibrillation (HP:0001663)1.26355505
185Mildly elevated creatine phosphokinase (HP:0008180)1.26076477
186Furrowed tongue (HP:0000221)1.23970243
187Tubular atrophy (HP:0000092)1.23034526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN6.89193567
2CASK4.24133322
3TNK24.23505017
4TTN3.14995166
5EPHA23.10506141
6TNIK2.87315390
7PNCK2.77351104
8STK392.76134082
9MAPKAPK32.51715785
10PRPF4B2.46031430
11NME12.44328203
12BMX2.21661116
13OXSR12.21169092
14NTRK32.18413973
15INSRR2.14299245
16EEF2K2.08526620
17MKNK22.06322321
18IRAK21.88518157
19PKN11.84280944
20MARK11.70461026
21UHMK11.66993289
22FES1.63808652
23AKT31.59384941
24MAP3K71.57448615
25MAPK121.54191263
26EPHA41.51036940
27MINK11.46204120
28IRAK11.44762595
29PAK61.44322430
30MAP3K21.40384825
31TRPM71.40090902
32BCR1.37424390
33MAPK151.37149205
34PAK31.36054899
35ERBB41.34455087
36MAP3K121.34046691
37ICK1.30690575
38PIK3CG1.28571373
39LIMK11.26826967
40GRK11.25427391
41DYRK21.25084033
42FGR1.24181659
43MAP3K131.16322228
44TRIB31.15211109
45STK241.14939316
46CAMK2A1.14381838
47MAPK131.13723172
48MAP2K71.13326360
49SMG11.11459859
50CAMK2B1.09759169
51NTRK21.09703534
52MST41.07251456
53CDK51.04081937
54PLK21.03954340
55MUSK1.02314473
56MAP3K31.02201099
57STK111.00576686
58ROCK21.00130857
59LRRK20.97874302
60TTK0.97704085
61AKT20.96258649
62GRK70.95951958
63FGFR20.92861265
64ERBB30.91555902
65BRAF0.89905724
66PRKCE0.88376867
67PHKG20.87036732
68PHKG10.87036732
69DYRK1A0.85939746
70CSK0.85874567
71CAMK1G0.85849634
72RIPK10.85509678
73BLK0.84880272
74TESK10.82867782
75TBK10.82212340
76CDK190.82122064
77MARK20.82082205
78NTRK10.82002517
79STK160.81748634
80EPHB10.81706128
81WNK40.81105162
82DDR20.79998659
83DYRK1B0.79405717
84CAMK2D0.76447110
85PRKCQ0.75938889
86TYRO30.75450666
87MAP2K40.75200697
88MKNK10.75111343
89ROCK10.74658348
90MAP2K30.71138182
91CDC42BPA0.69823518
92MAPKAPK50.68891309
93NEK60.68777647
94WNK30.67275308
95PDPK10.67004856
96STK100.66692971
97WNK10.65690059
98CAMK10.64659750
99CAMK2G0.64399950
100SGK4940.63591828
101SGK2230.63591828
102MAP3K40.62144020
103FER0.60783948
104PRKCG0.60379397
105PRKD20.59917801
106PRKD10.59626068
107FYN0.59154388
108CSNK1G30.58071359
109PRKAA10.56420338
110PRKG10.55047978
111SGK10.54517725
112MAP3K90.53725781
113NEK90.51887365
114MAPK100.50784479
115PRKAA20.50001886
116ABL20.49360336
117GRK50.49109543
118CDK30.47791681
119MAP2K10.47530566
120MST1R0.47002718
121ADRBK10.46875027
122MAP2K60.46810102
123PRKACA0.46141970
124CSNK1A1L0.45064832
125ADRBK20.44926694
126PTK2B0.44341325
127MET0.42011048
128EPHB20.41345570
129CSNK1G20.40414931
130CSNK1A10.40348144
131CCNB10.40193406
132SIK20.39796325
133ERBB20.39444424
134CSNK1G10.39275020
135BMPR20.38460650
136PINK10.37802411
137KSR20.37228627
138TLK10.35791919
139SGK30.33281239
140MAP2K20.33094887
141PRKCI0.32013286
142SGK20.31519618
143NLK0.30914218
144EPHA30.30525000
145STK380.29242984
146RPS6KB10.26181746
147RPS6KB20.25543281
148PDK10.25366175
149RPS6KA30.23072946
150MAP3K60.18967421
151DMPK0.18234994
152LATS10.18182389
153MAPK110.17828227
154RPS6KA20.17731710
155PRKCZ0.17354409
156PRKCA0.16929396
157LATS20.16138644
158CAMK40.15205909
159ZAP700.15131568
160ARAF0.14687381
161TAOK10.14653021
162CDK60.14251282

Predicted pathways (KEGG)

RankGene SetZ-score
1Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009804.32861237
2Phenylalanine metabolism_Homo sapiens_hsa003604.13286977
3Chemical carcinogenesis_Homo sapiens_hsa052043.50061387
4Tyrosine metabolism_Homo sapiens_hsa003503.04475284
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.03486145
6Nicotine addiction_Homo sapiens_hsa050332.94888460
7Fatty acid elongation_Homo sapiens_hsa000622.62255751
8Steroid hormone biosynthesis_Homo sapiens_hsa001402.60602830
9Oxidative phosphorylation_Homo sapiens_hsa001902.38421963
10GABAergic synapse_Homo sapiens_hsa047272.16094037
11Fatty acid degradation_Homo sapiens_hsa000712.11492144
12Glutamatergic synapse_Homo sapiens_hsa047242.08675089
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.05577533
14Glutathione metabolism_Homo sapiens_hsa004802.04313503
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.03516220
16Axon guidance_Homo sapiens_hsa043602.00851595
17Taste transduction_Homo sapiens_hsa047421.95347401
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93102611
19Cardiac muscle contraction_Homo sapiens_hsa042601.88265235
20Circadian rhythm_Homo sapiens_hsa047101.85484631
21Alzheimers disease_Homo sapiens_hsa050101.84677810
22Morphine addiction_Homo sapiens_hsa050321.80587984
23Parkinsons disease_Homo sapiens_hsa050121.80411669
24Salivary secretion_Homo sapiens_hsa049701.79846223
25Long-term depression_Homo sapiens_hsa047301.70469850
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.65103761
27Huntingtons disease_Homo sapiens_hsa050161.62758794
28Serotonergic synapse_Homo sapiens_hsa047261.58603283
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56392431
30Renin secretion_Homo sapiens_hsa049241.55210252
31Retinol metabolism_Homo sapiens_hsa008301.54555204
32Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.54133096
33Circadian entrainment_Homo sapiens_hsa047131.52415520
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51847643
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.49618444
36Pyruvate metabolism_Homo sapiens_hsa006201.49152295
37Long-term potentiation_Homo sapiens_hsa047201.47950438
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45799099
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.36193290
40Tight junction_Homo sapiens_hsa045301.34581081
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32826362
42Ovarian steroidogenesis_Homo sapiens_hsa049131.32530652
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.31801581
44Arginine and proline metabolism_Homo sapiens_hsa003301.31193017
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28633620
46Gastric acid secretion_Homo sapiens_hsa049711.28369770
47Gap junction_Homo sapiens_hsa045401.27291450
48Ether lipid metabolism_Homo sapiens_hsa005651.26724484
49Dorso-ventral axis formation_Homo sapiens_hsa043201.22975052
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22848875
51Cholinergic synapse_Homo sapiens_hsa047251.19933331
52ErbB signaling pathway_Homo sapiens_hsa040121.19818951
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19402083
54Phototransduction_Homo sapiens_hsa047441.19156853
55Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.18569284
56Renal cell carcinoma_Homo sapiens_hsa052111.18058287
57Amphetamine addiction_Homo sapiens_hsa050311.17955302
58Butanoate metabolism_Homo sapiens_hsa006501.14153511
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13544721
60Sulfur metabolism_Homo sapiens_hsa009201.13288059
61Peroxisome_Homo sapiens_hsa041461.13118666
62Dopaminergic synapse_Homo sapiens_hsa047281.12650435
63cAMP signaling pathway_Homo sapiens_hsa040241.12303637
64Calcium signaling pathway_Homo sapiens_hsa040201.11950438
65Cocaine addiction_Homo sapiens_hsa050301.11835354
66Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.09701192
67Vascular smooth muscle contraction_Homo sapiens_hsa042701.09607891
68Oxytocin signaling pathway_Homo sapiens_hsa049211.09151213
69Vitamin B6 metabolism_Homo sapiens_hsa007501.06873655
70Starch and sucrose metabolism_Homo sapiens_hsa005001.06566696
71Choline metabolism in cancer_Homo sapiens_hsa052311.05274023
72Melanogenesis_Homo sapiens_hsa049161.00482638
73Bile secretion_Homo sapiens_hsa049760.98692941
74PPAR signaling pathway_Homo sapiens_hsa033200.97551156
75Insulin secretion_Homo sapiens_hsa049110.96303779
76GnRH signaling pathway_Homo sapiens_hsa049120.94905045
77Propanoate metabolism_Homo sapiens_hsa006400.94710557
78Caffeine metabolism_Homo sapiens_hsa002320.92593954
79Collecting duct acid secretion_Homo sapiens_hsa049660.92056796
80Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90408845
81Olfactory transduction_Homo sapiens_hsa047400.90294497
82ABC transporters_Homo sapiens_hsa020100.87167902
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86115214
84Phospholipase D signaling pathway_Homo sapiens_hsa040720.84029807
85Synaptic vesicle cycle_Homo sapiens_hsa047210.83987716
86Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83042146
87Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81893287
88Insulin signaling pathway_Homo sapiens_hsa049100.81651238
89Arginine biosynthesis_Homo sapiens_hsa002200.81635632
90Ras signaling pathway_Homo sapiens_hsa040140.80270765
91Dilated cardiomyopathy_Homo sapiens_hsa054140.80190327
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79874758
93Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.79240160
94Glucagon signaling pathway_Homo sapiens_hsa049220.77888996
95Sphingolipid metabolism_Homo sapiens_hsa006000.76822038
96Insulin resistance_Homo sapiens_hsa049310.76610328
97Mineral absorption_Homo sapiens_hsa049780.75980763
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75371120
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74221132
100Pentose phosphate pathway_Homo sapiens_hsa000300.73640878
101Pancreatic secretion_Homo sapiens_hsa049720.71052433
102Carbon metabolism_Homo sapiens_hsa012000.69158779
103Steroid biosynthesis_Homo sapiens_hsa001000.66764930
104Tryptophan metabolism_Homo sapiens_hsa003800.65563152
105Fructose and mannose metabolism_Homo sapiens_hsa000510.62673963
106Estrogen signaling pathway_Homo sapiens_hsa049150.61958517
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.60620265
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60037429
109Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.56508482
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55798767
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.55615704
112Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55588556
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.55296073
114Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54629399
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.54246893
116Vibrio cholerae infection_Homo sapiens_hsa051100.54109728
117Vitamin digestion and absorption_Homo sapiens_hsa049770.53330415
118Fatty acid metabolism_Homo sapiens_hsa012120.52462346
119Melanoma_Homo sapiens_hsa052180.51842365
120beta-Alanine metabolism_Homo sapiens_hsa004100.50827361
121MAPK signaling pathway_Homo sapiens_hsa040100.49215435
122AMPK signaling pathway_Homo sapiens_hsa041520.48552858
123Prion diseases_Homo sapiens_hsa050200.48174486
124Adipocytokine signaling pathway_Homo sapiens_hsa049200.43841953
125Rap1 signaling pathway_Homo sapiens_hsa040150.42187397
126Hedgehog signaling pathway_Homo sapiens_hsa043400.41729202
127Adherens junction_Homo sapiens_hsa045200.41214770
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39711430
129Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39040241
130Metabolic pathways_Homo sapiens_hsa011000.38826538
131Histidine metabolism_Homo sapiens_hsa003400.38518801
132ECM-receptor interaction_Homo sapiens_hsa045120.38398686
133Linoleic acid metabolism_Homo sapiens_hsa005910.37936080
134Glioma_Homo sapiens_hsa052140.36866423
135Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36472802
136Hepatitis C_Homo sapiens_hsa051600.36434098
137Type II diabetes mellitus_Homo sapiens_hsa049300.36236626
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.35387238
139Basal cell carcinoma_Homo sapiens_hsa052170.35261515
140Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34696430
141Rheumatoid arthritis_Homo sapiens_hsa053230.34277865
142Phagosome_Homo sapiens_hsa041450.34133429
143Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.33434784
144Fatty acid biosynthesis_Homo sapiens_hsa000610.33238253
145Arachidonic acid metabolism_Homo sapiens_hsa005900.22490114
146Notch signaling pathway_Homo sapiens_hsa043300.22267797
147Amoebiasis_Homo sapiens_hsa051460.22109741
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.18595630
149Glycerolipid metabolism_Homo sapiens_hsa005610.18454238
150Nitrogen metabolism_Homo sapiens_hsa009100.18077708
151Complement and coagulation cascades_Homo sapiens_hsa046100.16304714
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14581341
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.10768614

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