FAM167A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)7.28243664
2thyroid hormone generation (GO:0006590)6.88753083
3thyroid hormone metabolic process (GO:0042403)5.96670443
4keratinization (GO:0031424)5.00221298
5hair cycle (GO:0042633)4.88553633
6molting cycle (GO:0042303)4.88553633
7desmosome organization (GO:0002934)4.58950449
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.42710598
9gland morphogenesis (GO:0022612)4.31602691
10negative regulation of hormone biosynthetic process (GO:0032353)4.21960290
11establishment of skin barrier (GO:0061436)4.19193794
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.18033427
13antigen processing and presentation of endogenous antigen (GO:0019883)4.06427234
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.02164930
15cellular response to vitamin D (GO:0071305)3.93144104
16cellular potassium ion homeostasis (GO:0030007)3.91398176
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.90035958
18pericardium development (GO:0060039)3.84619078
19regulation of water loss via skin (GO:0033561)3.82587949
20negative regulation of bone remodeling (GO:0046851)3.59060870
21negative regulation of hormone metabolic process (GO:0032351)3.53534409
22intermediate filament organization (GO:0045109)3.53529999
23regulation of transforming growth factor beta2 production (GO:0032909)3.51535350
24dendritic spine morphogenesis (GO:0060997)3.47892142
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47003724
26regulation of type B pancreatic cell apoptotic process (GO:2000674)3.46610024
27membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.41427628
28negative regulation of keratinocyte proliferation (GO:0010839)3.39237548
29bundle of His cell to Purkinje myocyte communication (GO:0086069)3.37709028
30lung epithelium development (GO:0060428)3.37053007
31cilium or flagellum-dependent cell motility (GO:0001539)3.34025937
32regulation of short-term neuronal synaptic plasticity (GO:0048172)3.33788352
33positive thymic T cell selection (GO:0045059)3.29978550
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.27821818
35potassium ion homeostasis (GO:0055075)3.26920290
36regulation of sister chromatid cohesion (GO:0007063)3.26105731
37insulin secretion (GO:0030073)3.26095531
38glutamate secretion (GO:0014047)3.25497038
39epidermis development (GO:0008544)3.21553877
40keratinocyte differentiation (GO:0030216)3.19375723
41synaptic vesicle maturation (GO:0016188)3.16683152
42mesenchymal cell differentiation involved in kidney development (GO:0072161)3.16569812
43mesenchymal cell differentiation involved in renal system development (GO:2001012)3.16569812
44negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13741988
45surfactant homeostasis (GO:0043129)3.13490150
46regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13035284
47regulation of respiratory system process (GO:0044065)3.13022759
48keratinocyte proliferation (GO:0043616)3.12070172
49cilium movement (GO:0003341)3.08787529
50positive regulation of Cdc42 GTPase activity (GO:0043089)3.08438878
51positive regulation of hair cycle (GO:0042635)3.07408216
52positive regulation of hair follicle development (GO:0051798)3.07408216
53negative regulation of dendrite morphogenesis (GO:0050774)3.06188037
54enteric nervous system development (GO:0048484)3.04995027
55cytoplasmic mRNA processing body assembly (GO:0033962)3.03560698
56positive regulation of growth hormone secretion (GO:0060124)3.03288592
57membrane repolarization during action potential (GO:0086011)3.02536074
58negative regulation of bone resorption (GO:0045779)3.01701254
59innervation (GO:0060384)2.99663204
60glycerophospholipid catabolic process (GO:0046475)2.98708569
61phosphatidylinositol dephosphorylation (GO:0046856)2.98393615
62phospholipid dephosphorylation (GO:0046839)2.96737209
63regulation of cardioblast proliferation (GO:0003264)2.95953064
64regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95953064
65peptide cross-linking (GO:0018149)2.94058814
66neuron cell-cell adhesion (GO:0007158)2.93671260
67negative regulation of tissue remodeling (GO:0034104)2.91572366
68behavioral response to nicotine (GO:0035095)2.91562889
69proline transport (GO:0015824)2.91528573
70auditory behavior (GO:0031223)2.91281875
71fusion of sperm to egg plasma membrane (GO:0007342)2.91133697
72locomotory exploration behavior (GO:0035641)2.90704741
73postsynaptic membrane organization (GO:0001941)2.90604619
74presynaptic membrane assembly (GO:0097105)2.89023874
75nephron tubule formation (GO:0072079)2.88759319
76macroautophagy (GO:0016236)2.88461085
77G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.88348831
78multicellular organismal water homeostasis (GO:0050891)2.88335936
79regulation of dendritic cell antigen processing and presentation (GO:0002604)2.87951273
80epithelial cell differentiation involved in prostate gland development (GO:0060742)2.87321882
81regulation of hair follicle development (GO:0051797)2.86687996
82astrocyte differentiation (GO:0048708)2.85622067
83cellular response to vitamin (GO:0071295)2.83862485
84regulation of neurotransmitter uptake (GO:0051580)2.83417396
85metanephric nephron tubule development (GO:0072234)2.82888306
86metanephric tubule development (GO:0072170)2.82888306
87establishment of planar polarity (GO:0001736)2.82345351
88establishment of tissue polarity (GO:0007164)2.82345351
89lung-associated mesenchyme development (GO:0060484)2.81424317
90negative regulation of cell fate specification (GO:0009996)2.81176644
91regulation of hair cycle (GO:0042634)2.80070594
92NIK/NF-kappaB signaling (GO:0038061)2.79944142
93ectoderm development (GO:0007398)2.79225774
94regulation of respiratory gaseous exchange (GO:0043576)2.77329696
95dorsal/ventral axis specification (GO:0009950)2.77293456
96axonemal dynein complex assembly (GO:0070286)2.77127762
97presynaptic membrane organization (GO:0097090)2.74118212
98positive regulation of neurotransmitter transport (GO:0051590)2.73336920
99embryonic foregut morphogenesis (GO:0048617)2.73139468
100cerebellar Purkinje cell layer development (GO:0021680)2.71340120
101epidermal cell differentiation (GO:0009913)2.70468109
102water homeostasis (GO:0030104)2.69088604
103germ cell migration (GO:0008354)2.67960246
104auditory receptor cell differentiation (GO:0042491)2.67784437
105lateral sprouting from an epithelium (GO:0060601)2.67431760
106tolerance induction (GO:0002507)2.67198513
107axonal fasciculation (GO:0007413)2.65982837
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.65282359
109detection of calcium ion (GO:0005513)2.64691036
110membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63585733
111hair follicle morphogenesis (GO:0031069)2.63292171
112lung lobe morphogenesis (GO:0060463)2.62992662
113neurotransmitter secretion (GO:0007269)2.62986560
114cell wall macromolecule metabolic process (GO:0044036)2.62948422
115cell wall macromolecule catabolic process (GO:0016998)2.62948422
116regulation of calcium ion-dependent exocytosis (GO:0017158)2.61457751
117chemosensory behavior (GO:0007635)2.61157144
118phosphorylated carbohydrate dephosphorylation (GO:0046838)2.59075470
119inositol phosphate dephosphorylation (GO:0046855)2.59075470
120peptide hormone processing (GO:0016486)2.57369412
121endothelial tube morphogenesis (GO:0061154)2.56183751
122morphogenesis of an endothelium (GO:0003159)2.56183751
123membrane repolarization (GO:0086009)2.53662968
124regulation of hippo signaling (GO:0035330)2.53345992
125thymic T cell selection (GO:0045061)2.52411427
126glial cell proliferation (GO:0014009)2.52045748
127positive regulation of granulocyte chemotaxis (GO:0071624)2.51955506
128cell-substrate junction assembly (GO:0007044)2.51577386
129non-canonical Wnt signaling pathway (GO:0035567)2.51385544
130regulation of Cdc42 GTPase activity (GO:0043088)2.50840067
131regulation of neurotransmitter transport (GO:0051588)2.50733629
132antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.50638826
133antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.50638826
134osteoblast development (GO:0002076)2.50566210
135limb bud formation (GO:0060174)2.50504147
136synapse assembly (GO:0007416)2.49139149
137peptide hormone secretion (GO:0030072)2.49034706
138response to dietary excess (GO:0002021)2.48657851
139positive regulation of meiosis (GO:0045836)2.47474187
140suckling behavior (GO:0001967)2.47135113
141cochlea development (GO:0090102)2.46912553
142potassium ion import (GO:0010107)2.46419249
143cellular response to prostaglandin stimulus (GO:0071379)2.46031646
144regulation of cardioblast differentiation (GO:0051890)2.44851265
145Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.44735911
146inositol phosphate catabolic process (GO:0071545)2.44422211
147multicellular organism reproduction (GO:0032504)2.44300655
148regulation of establishment of planar polarity (GO:0090175)2.44197798
149endocardial cushion morphogenesis (GO:0003203)2.42909946
150hair follicle development (GO:0001942)2.41624586
151regulation of steroid hormone biosynthetic process (GO:0090030)2.41596043
152epithelial cilium movement (GO:0003351)2.40955236
153regulation of podosome assembly (GO:0071801)2.40918359
154acrosome assembly (GO:0001675)2.40835818
155peptide secretion (GO:0002790)2.40670048
156molting cycle process (GO:0022404)2.39897467
157hair cycle process (GO:0022405)2.39897467
158response to gravity (GO:0009629)2.39761398
159chemical homeostasis within a tissue (GO:0048875)2.39004110
160negative regulation of dendrite development (GO:2000171)2.38615174
161regulation of neuronal synaptic plasticity (GO:0048168)2.37307115
162regulation of synaptic vesicle exocytosis (GO:2000300)2.36825699
163neuronal ion channel clustering (GO:0045161)2.36717829
164negative regulation of interleukin-8 production (GO:0032717)2.35856206
165neuron recognition (GO:0008038)2.34026487
166genitalia morphogenesis (GO:0035112)2.33681565
167regulation of myelination (GO:0031641)2.33657360
168metanephric nephron epithelium development (GO:0072243)2.33207602
169negative regulation of chondrocyte differentiation (GO:0032331)2.33057175
170reproduction (GO:0000003)2.32564707
171positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.32408127
172sodium ion export (GO:0071436)2.31690889
173oocyte development (GO:0048599)2.31470811
174dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31106392
175body morphogenesis (GO:0010171)2.30891212
176atrioventricular valve morphogenesis (GO:0003181)2.28697183
177regulation of neurotransmitter secretion (GO:0046928)2.28549280
178regulation of Rac protein signal transduction (GO:0035020)2.28319993
179regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.28216815
180dendritic cell chemotaxis (GO:0002407)2.27030039
181axon ensheathment in central nervous system (GO:0032291)2.26200598
182central nervous system myelination (GO:0022010)2.26200598
183mesenchyme morphogenesis (GO:0072132)2.25997537
184positive regulation of meiotic cell cycle (GO:0051446)2.25875449
185regulation of acrosome reaction (GO:0060046)2.25800704
186regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.25645288
187endocrine pancreas development (GO:0031018)2.24840899
188calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.24762132
189positive regulation of transcription regulatory region DNA binding (GO:2000679)2.24421907
190relaxation of smooth muscle (GO:0044557)2.24090810
191dendritic spine organization (GO:0097061)2.24089697
192regulation of synaptic vesicle transport (GO:1902803)2.22831785
193synaptic vesicle exocytosis (GO:0016079)2.21788308
194positive regulation of insulin secretion (GO:0032024)2.20955904
195neurotransmitter transport (GO:0006836)2.19624194
196positive regulation of amine transport (GO:0051954)2.18583765
197signal release (GO:0023061)2.18020845
198regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.16588542

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.33280518
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.89062776
3GBX2_23144817_ChIP-Seq_PC3_Human2.82551742
4* SOX9_24532713_ChIP-Seq_HFSC_Mouse2.80465961
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.68587861
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.64288153
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.48599348
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43407986
9SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.34564578
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.33096479
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.16264668
12REST_21632747_ChIP-Seq_MESCs_Mouse2.15973097
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09575654
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.01385650
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00569972
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.00287203
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.00287203
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.95398091
19REST_18959480_ChIP-ChIP_MESCs_Mouse1.78172499
20BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76344820
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.70212519
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70082983
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.67813024
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67697561
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.67644711
26AHR_22903824_ChIP-Seq_MCF-7_Human1.67360307
27* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.65706329
28FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.64755158
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.63683632
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.62378020
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60422835
32SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.57231145
33SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.57231145
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.55978952
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.55760797
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55288736
37CJUN_26792858_Chip-Seq_BT549_Human1.55236156
38RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.54921759
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.54526058
40DROSHA_22980978_ChIP-Seq_HELA_Human1.48483169
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47390634
42RUNX1_27514584_Chip-Seq_MCF-7_Human1.46252775
43TCF4_18268006_ChIP-ChIP_LS174T_Human1.42819693
44ARNT_22903824_ChIP-Seq_MCF-7_Human1.42386701
45* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41252743
46TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39548458
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.39330163
48RARB_27405468_Chip-Seq_BRAIN_Mouse1.38908438
49VDR_24787735_ChIP-Seq_THP-1_Human1.38167615
50TCF7_22412390_ChIP-Seq_EML_Mouse1.37674340
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.36925855
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36468052
53STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.36458338
54EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34155353
55TP53_18474530_ChIP-ChIP_U2OS_Human1.33145789
56* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30771462
57ELK4_26923725_Chip-Seq_MESODERM_Mouse1.30658766
58SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30411583
59* SMAD3_21741376_ChIP-Seq_HESCs_Human1.29221997
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28028937
61STAT3_23295773_ChIP-Seq_U87_Human1.26742809
62TP63_23658742_ChIP-Seq_EP156T_Human1.26119675
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26064405
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26039698
65RNF2_27304074_Chip-Seq_ESCs_Mouse1.25406066
66BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.25018474
67* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.24882587
68OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24657951
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.24017795
70MYC_22102868_ChIP-Seq_BL_Human1.20894728
71P63_26484246_Chip-Seq_KERATINOCYTES_Human1.20852287
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20424833
73TRIM28_21343339_ChIP-Seq_HEK293_Human1.19534954
74AR_25329375_ChIP-Seq_VCAP_Human1.18810650
75TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17896268
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16181320
77TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16109055
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16025910
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13983223
80EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13871210
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13404190
82RUNX_20019798_ChIP-Seq_JUKART_Human1.13349078
83TCF4_23295773_ChIP-Seq_U87_Human1.13179115
84KDM2B_26808549_Chip-Seq_K562_Human1.11721054
85UBF1/2_26484160_Chip-Seq_HMECs_Human1.11440614
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.09600281
87* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09189619
88ISL1_27105846_Chip-Seq_CPCs_Mouse1.09080290
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.09037220
90* RNF2_27304074_Chip-Seq_NSC_Mouse1.08806386
91NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08584625
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08581273
93KLF5_25053715_ChIP-Seq_YYC3_Human1.08568417
94RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07484147
95SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07298595
96AR_19668381_ChIP-Seq_PC3_Human1.06097331
97NANOG_18555785_Chip-Seq_ESCs_Mouse1.05218444
98VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.05132537
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04100120
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04003328
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.03893135
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03833432
103* SMAD4_21741376_ChIP-Seq_HESCs_Human1.03357208
104* P300_19829295_ChIP-Seq_ESCs_Human1.03296642
105KDM2B_26808549_Chip-Seq_DND41_Human1.02718234
106EZH2_22144423_ChIP-Seq_EOC_Human1.01746356
107PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00788045
108BCAT_22108803_ChIP-Seq_LS180_Human0.99752527
109* RUNX2_22187159_ChIP-Seq_PCA_Human0.99644470
110WT1_19549856_ChIP-ChIP_CCG9911_Human0.99368889
111RING1B_27294783_Chip-Seq_ESCs_Mouse0.99355106
112TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99339327
113CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99279717
114TAF15_26573619_Chip-Seq_HEK293_Human0.98686368
115KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98356752
116AR_21572438_ChIP-Seq_LNCaP_Human0.97847612
117SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96181072
118CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95491329
119STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95279442
120ZNF263_19887448_ChIP-Seq_K562_Human0.95139830
121* EZH2_27294783_Chip-Seq_ESCs_Mouse0.95115164
122CBP_20019798_ChIP-Seq_JUKART_Human0.94965764
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.94965764
124SCL_19346495_ChIP-Seq_HPC-7_Human0.94883733
125MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94879425
126ZFP281_27345836_Chip-Seq_ESCs_Mouse0.94548713
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93527993
128TP63_22573176_ChIP-Seq_HFKS_Human0.93233207
129ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92597961
130STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.92428786
131CTNNB1_20460455_ChIP-Seq_HCT116_Human0.91559962
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91200825
133KDM2B_26808549_Chip-Seq_REH_Human0.91025911
134WDR5_24793694_ChIP-Seq_LNCAP_Human0.90787757
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90569955
136ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90552951
137JARID2_20064375_ChIP-Seq_MESCs_Mouse0.89565361
138VDR_24763502_ChIP-Seq_THP-1_Human0.88733830
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88399202
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88324195
141SALL1_21062744_ChIP-ChIP_HESCs_Human0.88006656
142WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86898601
143EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.86608979
144TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86398369
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86304768
146SMAD3_21741376_ChIP-Seq_ESCs_Human0.85748573
147TBX20_22328084_ChIP-Seq_HEART_Mouse0.85072518
148TBX20_22080862_ChIP-Seq_HEART_Mouse0.85072518
149CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84767672
150TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.84162091
151SOX2_20726797_ChIP-Seq_SW620_Human0.83137451
152TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82064498
153POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.82064498
154EP300_21415370_ChIP-Seq_HL-1_Mouse0.82045727
155EZH2_27304074_Chip-Seq_ESCs_Mouse0.81655386
156RUNX1_26923725_Chip-Seq_HPCs_Mouse0.80910464
157FOXM1_26456572_ChIP-Seq_MCF-7_Human0.80733824
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.79920383
159ELK3_25401928_ChIP-Seq_HUVEC_Human0.79745010
160MTF2_20144788_ChIP-Seq_MESCs_Mouse0.78323339
161WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.78076466
162GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.77909887
163RING1B_27294783_Chip-Seq_NPCs_Mouse0.77861436
164JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77671030
165SMC4_20622854_ChIP-Seq_HELA_Human0.76524559
166SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.76468665
167CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76095299
168PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74898044

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat5.64877173
2MP0010234_abnormal_vibrissa_follicle4.08149429
3MP0000579_abnormal_nail_morphology3.94980218
4MP0009780_abnormal_chondrocyte_physiolo3.50285802
5MP0002796_impaired_skin_barrier3.19359560
6MP0010386_abnormal_urinary_bladder3.17800365
7MP0001346_abnormal_lacrimal_gland3.08798495
8MP0002163_abnormal_gland_morphology3.04304296
9MP0000685_abnormal_immune_system2.96007273
10MP0005379_endocrine/exocrine_gland_phen2.90006303
11MP0004885_abnormal_endolymph2.77850239
12MP0004859_abnormal_synaptic_plasticity2.76363806
13MP0000383_abnormal_hair_follicle2.74071189
14MP0010678_abnormal_skin_adnexa2.68456809
15MP0004270_analgesia2.62946943
16MP0003283_abnormal_digestive_organ2.60899827
17MP0005248_abnormal_Harderian_gland2.53526843
18MP0001849_ear_inflammation2.44537848
19MP0000681_abnormal_thyroid_gland2.40929464
20MP0002822_catalepsy2.37358095
21MP0003453_abnormal_keratinocyte_physiol2.35091158
22MP0002098_abnormal_vibrissa_morphology2.33711009
23MP0000427_abnormal_hair_cycle2.24893009
24MP0002876_abnormal_thyroid_physiology2.22047418
25MP0005275_abnormal_skin_tensile2.18950802
26MP0001348_abnormal_lacrimal_gland2.17610301
27MP0001216_abnormal_epidermal_layer2.09389404
28MP0002234_abnormal_pharynx_morphology2.06881944
29MP0003787_abnormal_imprinting2.06224797
30MP0000537_abnormal_urethra_morphology2.05792462
31MP0001984_abnormal_olfaction2.03652068
32MP0003705_abnormal_hypodermis_morpholog2.02466918
33MP0003879_abnormal_hair_cell2.01814660
34MP0005076_abnormal_cell_differentiation2.00894136
35MP0002877_abnormal_melanocyte_morpholog1.97648540
36MP0002060_abnormal_skin_morphology1.95862383
37MP0005501_abnormal_skin_physiology1.91223875
38MP0010352_gastrointestinal_tract_polyps1.89855503
39MP0009046_muscle_twitch1.88475070
40MP0000762_abnormal_tongue_morphology1.83497101
41MP0003635_abnormal_synaptic_transmissio1.82325933
42MP0003122_maternal_imprinting1.79791312
43MP0005423_abnormal_somatic_nervous1.77270523
44MP0009745_abnormal_behavioral_response1.73877395
45MP0003300_gastrointestinal_ulcer1.73132212
46MP0002734_abnormal_mechanical_nocicepti1.71942755
47MP0001944_abnormal_pancreas_morphology1.69420550
48MP0003880_abnormal_central_pattern1.69210314
49MP0001501_abnormal_sleep_pattern1.68665254
50MP0004947_skin_inflammation1.67093686
51MP0002272_abnormal_nervous_system1.65657993
52MP0002064_seizures1.65228481
53MP0002638_abnormal_pupillary_reflex1.64358534
54MP0000377_abnormal_hair_follicle1.63187949
55MP0003566_abnormal_cell_adhesion1.63010526
56MP0000013_abnormal_adipose_tissue1.61886143
57MP0000647_abnormal_sebaceous_gland1.60713509
58MP0001835_abnormal_antigen_presentation1.60010167
59MP0005387_immune_system_phenotype1.59318674
60MP0001790_abnormal_immune_system1.59318674
61MP0002837_dystrophic_cardiac_calcinosis1.55002180
62MP0002282_abnormal_trachea_morphology1.54234067
63MP0000467_abnormal_esophagus_morphology1.54131400
64MP0000462_abnormal_digestive_system1.54063564
65MP0004043_abnormal_pH_regulation1.50639916
66MP0002063_abnormal_learning/memory/cond1.50596063
67MP0010771_integument_phenotype1.50157123
68MP0005646_abnormal_pituitary_gland1.48963789
69MP0002572_abnormal_emotion/affect_behav1.48957717
70MP0003303_peritoneal_inflammation1.46208770
71MP0002928_abnormal_bile_duct1.44669393
72MP0001502_abnormal_circadian_rhythm1.40199449
73MP0006054_spinal_hemorrhage1.39167860
74MP0005645_abnormal_hypothalamus_physiol1.36994565
75MP0002653_abnormal_ependyma_morphology1.36729611
76MP0001800_abnormal_humoral_immune1.36225578
77MP0001970_abnormal_pain_threshold1.35418493
78MP0000778_abnormal_nervous_system1.35233256
79MP0008789_abnormal_olfactory_epithelium1.32889734
80MP0006276_abnormal_autonomic_nervous1.32090961
81MP0000566_synostosis1.31372693
82MP0002735_abnormal_chemical_nociception1.30937588
83MP0000631_abnormal_neuroendocrine_gland1.28645433
84MP0000465_gastrointestinal_hemorrhage1.27915377
85MP0003950_abnormal_plasma_membrane1.27093618
86MP0003183_abnormal_peptide_metabolism1.25883741
87MP0008569_lethality_at_weaning1.25770598
88MP0003763_abnormal_thymus_physiology1.25549667
89MP0002733_abnormal_thermal_nociception1.25351352
90MP0008961_abnormal_basal_metabolism1.21655146
91MP0000678_abnormal_parathyroid_gland1.20621506
92MP0002557_abnormal_social/conspecific_i1.19990922
93MP0004782_abnormal_surfactant_physiolog1.18544463
94MP0002184_abnormal_innervation1.18503263
95MP0003123_paternal_imprinting1.18145406
96MP0002896_abnormal_bone_mineralization1.17258108
97MP0002693_abnormal_pancreas_physiology1.17254420
98MP0005410_abnormal_fertilization1.15030103
99MP0000613_abnormal_salivary_gland1.13581463
100MP0002751_abnormal_autonomic_nervous1.09451062
101MP0001851_eye_inflammation1.09286927
102MP0003633_abnormal_nervous_system1.07269440
103MP0005623_abnormal_meninges_morphology1.07147475
104MP0001756_abnormal_urination1.06438563
105MP0006072_abnormal_retinal_apoptosis1.05502043
106MP0002909_abnormal_adrenal_gland1.05494971
107MP0009053_abnormal_anal_canal1.04506466
108MP0001486_abnormal_startle_reflex1.03407657
109MP0002277_abnormal_respiratory_mucosa1.00296948
110MP0001664_abnormal_digestion0.98573476
111MP0001873_stomach_inflammation0.98557669
112MP0009250_abnormal_appendicular_skeleto0.98484923
113MP0001485_abnormal_pinna_reflex0.98222747
114MP0003755_abnormal_palate_morphology0.98140427
115MP0004858_abnormal_nervous_system0.97718685
116MP0008877_abnormal_DNA_methylation0.96868659
117MP0002295_abnormal_pulmonary_circulatio0.96413528
118MP0000538_abnormal_urinary_bladder0.96409217
119MP0009384_cardiac_valve_regurgitation0.96394646
120MP0003890_abnormal_embryonic-extraembry0.96206822
121MP0001270_distended_abdomen0.95147013
122MP0003868_abnormal_feces_composition0.95124662
123MP0001968_abnormal_touch/_nociception0.94635492
124MP0001340_abnormal_eyelid_morphology0.94284316
125MP0001963_abnormal_hearing_physiology0.93269104
126MP0005000_abnormal_immune_tolerance0.92951198
127MP0005220_abnormal_exocrine_pancreas0.92944829
128MP0002882_abnormal_neuron_morphology0.90463870
129MP0000955_abnormal_spinal_cord0.90388907
130MP0009931_abnormal_skin_appearance0.90138586
131MP0003329_amyloid_beta_deposits0.89916548
132MP0000003_abnormal_adipose_tissue0.89867307
133MP0001905_abnormal_dopamine_level0.89418212
134MP0005551_abnormal_eye_electrophysiolog0.89155955
135MP0003953_abnormal_hormone_level0.88943285
136MP0003091_abnormal_cell_migration0.88342285
137MP0004134_abnormal_chest_morphology0.87951774
138MP0010030_abnormal_orbit_morphology0.87852915
139MP0004510_myositis0.86691895
140MP0000367_abnormal_coat/_hair0.86656148
141MP0002009_preneoplasia0.85662280
142MP0002405_respiratory_system_inflammati0.85618699
143MP0002078_abnormal_glucose_homeostasis0.85258132
144MP0001440_abnormal_grooming_behavior0.84299452
145MP0000534_abnormal_ureter_morphology0.83655896
146MP0005503_abnormal_tendon_morphology0.83531216
147MP0004381_abnormal_hair_follicle0.83383930
148MP0001958_emphysema0.82589410
149MP0000639_abnormal_adrenal_gland0.82544111
150MP0003045_fibrosis0.82352121
151MP0003634_abnormal_glial_cell0.80916522
152MP0002233_abnormal_nose_morphology0.80331157
153MP0001188_hyperpigmentation0.80008752
154MP0005386_behavior/neurological_phenoty0.79037935
155MP0004924_abnormal_behavior0.79037935
156MP0002452_abnormal_antigen_presenting0.79021242
157MP0008004_abnormal_stomach_pH0.78174415
158MP0000470_abnormal_stomach_morphology0.78153767
159MP0003690_abnormal_glial_cell0.78126547
160MP0002116_abnormal_craniofacial_bone0.77746794
161MP0003195_calcinosis0.77106754
162MP0002066_abnormal_motor_capabilities/c0.76436524
163MP0000428_abnormal_craniofacial_morphol0.75235953
164MP0001299_abnormal_eye_distance/0.74422492
165MP0004811_abnormal_neuron_physiology0.73992430
166MP0003121_genomic_imprinting0.73824774
167MP0002067_abnormal_sensory_capabilities0.73458678
168MP0005023_abnormal_wound_healing0.73080976
169MP0003631_nervous_system_phenotype0.71825157
170MP0002697_abnormal_eye_size0.70049038
171MP0000432_abnormal_head_morphology0.69466414
172MP0002109_abnormal_limb_morphology0.68811117
173MP0001881_abnormal_mammary_gland0.67334806
174MP0005394_taste/olfaction_phenotype0.66931047
175MP0005499_abnormal_olfactory_system0.66931047
176MP0000733_abnormal_muscle_development0.66052753
177MP0003935_abnormal_craniofacial_develop0.65333884
178MP0005310_abnormal_salivary_gland0.64775803
179MP0005257_abnormal_intraocular_pressure0.63826931
180MP0010155_abnormal_intestine_physiology0.63582168
181MP0003115_abnormal_respiratory_system0.63289802
182MP0001191_abnormal_skin_condition0.63014819
183MP0002177_abnormal_outer_ear0.62060056
184MP0000627_abnormal_mammary_gland0.60904586
185MP0003937_abnormal_limbs/digits/tail_de0.59811844
186MP0002138_abnormal_hepatobiliary_system0.59247725

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)5.33401998
2Goiter (HP:0000853)5.07901680
3Fragile nails (HP:0001808)5.02886549
4Milia (HP:0001056)4.84814797
5Plantar hyperkeratosis (HP:0007556)4.64357708
6Thyroid-stimulating hormone excess (HP:0002925)4.08554623
7Asymmetry of the thorax (HP:0001555)4.06171513
8Abnormality of nail color (HP:0100643)3.97542814
9Congenital sensorineural hearing impairment (HP:0008527)3.97142836
10Nasal polyposis (HP:0100582)3.68857841
11Right ventricular cardiomyopathy (HP:0011663)3.50275105
12Increased IgE level (HP:0003212)3.47425304
13Hyperthyroidism (HP:0000836)3.43031380
14Thyroid carcinoma (HP:0002890)3.37707733
15Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.36230226
16Hypothermia (HP:0002045)3.31890300
17Woolly hair (HP:0002224)3.24606320
18Hyperinsulinemic hypoglycemia (HP:0000825)3.14621809
19Palmoplantar hyperkeratosis (HP:0000972)3.13388480
20Hypotrichosis (HP:0001006)3.11719452
21Atrophic scars (HP:0001075)3.05367475
22Hypoglycemic seizures (HP:0002173)3.02627410
23Abnormality of the nasal mucosa (HP:0000433)2.98489706
24Rhinitis (HP:0012384)2.95960054
25Palmar hyperkeratosis (HP:0010765)2.95334921
26Rectal prolapse (HP:0002035)2.86901012
27Nail dystrophy (HP:0008404)2.85974241
28Natal tooth (HP:0000695)2.85374203
29Enlarged penis (HP:0000040)2.82848536
30Hypoglycemic coma (HP:0001325)2.80772607
31Xerostomia (HP:0000217)2.79843044
32Large for gestational age (HP:0001520)2.79428889
33Hypoventilation (HP:0002791)2.77017299
34Abnormal respiratory motile cilium physiology (HP:0012261)2.75260415
35Action tremor (HP:0002345)2.74179528
36Abnormal pancreas size (HP:0012094)2.74079519
37Hemiparesis (HP:0001269)2.72355103
38Pili torti (HP:0003777)2.70491253
39Lip pit (HP:0100267)2.70188363
40Mild short stature (HP:0003502)2.67920497
41Agammaglobulinemia (HP:0004432)2.64623980
42Hyperglycemia (HP:0003074)2.62688253
43Increased circulating renin level (HP:0000848)2.61943766
44Hyperparathyroidism (HP:0000843)2.60556803
45Epileptiform EEG discharges (HP:0011182)2.56069309
46Recurrent bronchitis (HP:0002837)2.53734902
47EEG with generalized epileptiform discharges (HP:0011198)2.53157953
48Advanced eruption of teeth (HP:0006288)2.52045031
49Abnormality of the gastric mucosa (HP:0004295)2.50193695
50Intestinal atresia (HP:0011100)2.49585242
51Agitation (HP:0000713)2.48027895
52Abnormal ciliary motility (HP:0012262)2.46469277
53Myokymia (HP:0002411)2.44853612
54Abnormal blistering of the skin (HP:0008066)2.44426282
55Bronchitis (HP:0012387)2.41635054
56Late onset (HP:0003584)2.40544473
57Hypoplasia of dental enamel (HP:0006297)2.36189847
58Chronic otitis media (HP:0000389)2.36119522
59Urethral obstruction (HP:0000796)2.34926786
60Viral hepatitis (HP:0006562)2.33383053
61Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.33231529
62Buphthalmos (HP:0000557)2.32456015
63Chronic sinusitis (HP:0011109)2.31794768
64Amelogenesis imperfecta (HP:0000705)2.30402667
65Bowel diverticulosis (HP:0005222)2.29136840
66Follicular hyperkeratosis (HP:0007502)2.29114745
67Keratoconjunctivitis (HP:0001096)2.26062508
68Ketoacidosis (HP:0001993)2.25992513
69Hypsarrhythmia (HP:0002521)2.24610686
70Chronic bronchitis (HP:0004469)2.23485283
71Volvulus (HP:0002580)2.22064483
72Neoplasm of the thyroid gland (HP:0100031)2.21126347
73Interstitial pulmonary disease (HP:0006530)2.19058075
74Abnormality of proline metabolism (HP:0010907)2.16783416
75Hydroxyprolinuria (HP:0003080)2.16783416
76Absent/shortened dynein arms (HP:0200106)2.16405808
77Dynein arm defect of respiratory motile cilia (HP:0012255)2.16405808
78Abnormality of calcium-phosphate metabolism (HP:0100530)2.12812235
79Germ cell neoplasia (HP:0100728)2.12289900
80Abnormality of abdominal situs (HP:0011620)2.11547231
81Abdominal situs inversus (HP:0003363)2.11547231
82Insulin-resistant diabetes mellitus (HP:0000831)2.11325059
83Blepharitis (HP:0000498)2.06976694
84Anxiety (HP:0000739)2.04382377
85Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.04268933
86Postural tremor (HP:0002174)2.03841413
87Generalized tonic-clonic seizures (HP:0002069)2.03773673
88Abnormality of dentin (HP:0010299)2.03264983
89Increased density of long bones (HP:0006392)2.03088578
90Bronchiectasis (HP:0002110)2.02251049
91Pheochromocytoma (HP:0002666)2.02246859
92Hamartoma of the eye (HP:0010568)2.02095838
93Hypercortisolism (HP:0001578)2.01705432
94Intention tremor (HP:0002080)2.00278695
95Subacute progressive viral hepatitis (HP:0006572)1.99800068
96Congenital malformation of the right heart (HP:0011723)1.98471167
97Double outlet right ventricle (HP:0001719)1.98471167
98Eczematoid dermatitis (HP:0000976)1.98193176
99Coronal craniosynostosis (HP:0004440)1.97648808
100Recurrent sinusitis (HP:0011108)1.96656352
101Tracheomalacia (HP:0002779)1.96441460
102Supranuclear gaze palsy (HP:0000605)1.96006697
103Congenital glaucoma (HP:0001087)1.94671237
104Fibular hypoplasia (HP:0003038)1.93599613
105Abnormal respiratory epithelium morphology (HP:0012253)1.93431653
106Abnormal respiratory motile cilium morphology (HP:0005938)1.93431653
107Torticollis (HP:0000473)1.91678269
108Failure to thrive in infancy (HP:0001531)1.91397674
109Small epiphyses (HP:0010585)1.91003499
110Fatigable weakness (HP:0003473)1.90675256
111Abnormality of the neuromuscular junction (HP:0003398)1.90675256
112Hyperphosphatemia (HP:0002905)1.90045699
113Shallow orbits (HP:0000586)1.88863136
114Neoplasm of the adrenal cortex (HP:0100641)1.86992230
115Hypoplasia of the fovea (HP:0007750)1.86847576
116Aplasia/Hypoplasia of the fovea (HP:0008060)1.86847576
117Focal seizures (HP:0007359)1.85748265
118Amblyopia (HP:0000646)1.85510360
119Progressive cerebellar ataxia (HP:0002073)1.83777813
120Orchitis (HP:0100796)1.82607092
121Gastrointestinal stroma tumor (HP:0100723)1.82570993
122Hypothyroidism (HP:0000821)1.80975023
123Neoplasm of the heart (HP:0100544)1.80125236
124Bronchomalacia (HP:0002780)1.79404520
125Down-sloping shoulders (HP:0200021)1.78311774
126Ridged nail (HP:0001807)1.77941502
127Thoracolumbar scoliosis (HP:0002944)1.77604591
128Turricephaly (HP:0000262)1.77033385
129Aqueductal stenosis (HP:0002410)1.76625186
130Craniofacial hyperostosis (HP:0004493)1.76252504
131Shawl scrotum (HP:0000049)1.76154290
132Carious teeth (HP:0000670)1.75953480
133Colitis (HP:0002583)1.75707544
134Macroorchidism (HP:0000053)1.75584230
135Optic neuritis (HP:0100653)1.75550397
136Retrobulbar optic neuritis (HP:0100654)1.75550397
137Synostosis involving the elbow (HP:0003938)1.75200710
138Humeroradial synostosis (HP:0003041)1.75200710
139Alopecia of scalp (HP:0002293)1.74206261
140Abnormality of molar morphology (HP:0011070)1.73317419
141Abnormality of molar (HP:0011077)1.73317419
142Abnormality of the aortic arch (HP:0012303)1.73261091
143Neuroendocrine neoplasm (HP:0100634)1.71997291
144Epiphyseal dysplasia (HP:0002656)1.71991512
145Erythema (HP:0010783)1.71865757
146Testicular neoplasm (HP:0010788)1.71525570
147Abnormality of cochlea (HP:0000375)1.70866277
148Round ear (HP:0100830)1.70852576
149Hypodontia (HP:0000668)1.70197558
150Hypokinesia (HP:0002375)1.69207173
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.68829831
152Short 4th metacarpal (HP:0010044)1.68829831
153Emphysema (HP:0002097)1.68634311
154Atrioventricular canal defect (HP:0006695)1.67570685
155Broad ribs (HP:0000885)1.67157850
156Abnormality of the fingertips (HP:0001211)1.66907777
157Hepatoblastoma (HP:0002884)1.65831366
158Truncus arteriosus (HP:0001660)1.64565397
159Dysdiadochokinesis (HP:0002075)1.64403363
160Hypercalciuria (HP:0002150)1.63742316
161Inflammation of the large intestine (HP:0002037)1.63446173
162Cellulitis (HP:0100658)1.62816511
163Ankyloglossia (HP:0010296)1.62727040
164Metabolic alkalosis (HP:0200114)1.62543540
165Myositis (HP:0100614)1.62260600
166Unilateral renal agenesis (HP:0000122)1.61387027
167Neurofibrillary tangles (HP:0002185)1.61359265
168Insulin resistance (HP:0000855)1.61094866
169Megalencephaly (HP:0001355)1.60181237
170Abnormality of permanent molar morphology (HP:0011071)1.59920670
171Abnormality of the dental root (HP:0006486)1.59920670
172Taurodontia (HP:0000679)1.59920670
173Increased nuchal translucency (HP:0010880)1.59604527
174Coarse facial features (HP:0000280)1.56244660
175Mixed hearing impairment (HP:0000410)1.56158279
176Abnormal hair laboratory examination (HP:0003328)1.55828163
177Gastrointestinal inflammation (HP:0004386)1.55556057
178Orthostatic hypotension (HP:0001278)1.53274631
179Menstrual irregularities (HP:0000858)1.53250834
180Abnormality of renin-angiotensin system (HP:0000847)1.53027163
181Laryngomalacia (HP:0001601)1.51678720
182Abnormality of the fingernails (HP:0001231)1.51341708
183Gastrointestinal carcinoma (HP:0002672)1.50889834
184Malignant gastrointestinal tract tumors (HP:0006749)1.50889834
185Parakeratosis (HP:0001036)1.50334102
186Papilloma (HP:0012740)1.49677756
187Verrucae (HP:0200043)1.49677756
188Occipital encephalocele (HP:0002085)1.48408860
189Premature loss of primary teeth (HP:0006323)1.48351405
190Hyperacusis (HP:0010780)1.47683666

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK23.75968745
2NTRK33.59205653
3AKT33.29168514
4EPHA32.85614020
5EPHB22.85306387
6MAPK152.79807158
7LATS12.65730911
8NTRK12.53963327
9SIK32.38909222
10SIK12.33413533
11EEF2K2.28234551
12EPHB12.25087342
13FRK2.23480652
14CASK2.13455328
15MAP3K142.12704587
16PTK62.12238772
17NTRK22.09933190
18MAP4K12.05969201
19INSRR2.00137800
20LRRK21.85762512
21FER1.78663320
22UHMK11.76493609
23FGFR31.70450670
24CHUK1.69761171
25LIMK11.68945560
26ERN11.68502427
27MAP3K41.68428732
28DAPK21.63435668
29PHKG21.60908523
30PHKG11.60908523
31NLK1.58768326
32TRIB31.55333852
33HIPK21.49589105
34LATS21.48878711
35PASK1.45917601
36FGFR41.42623408
37PRKG21.42597151
38PAK31.40862698
39TRPM71.40394487
40PAK61.38437617
41MAP3K131.37691967
42GRK61.37548073
43STK241.35724339
44BMPR21.34404224
45STK38L1.32080010
46PRKCG1.31425500
47MAP3K91.29039956
48TAOK31.26300915
49DYRK1B1.24854215
50STK101.24703096
51BTK1.23932209
52PINK11.19727514
53PNCK1.18279143
54MAP3K101.14206150
55SIK21.13670644
56PRKCH1.11716144
57MAP2K71.11165832
58CDK61.11162257
59SGK21.10475806
60NEK61.06952659
61SGK2231.02565332
62SGK4941.02565332
63STK31.01990674
64IRAK31.01635205
65MELK1.00021803
66CDK50.99709459
67PLK20.98777294
68TGFBR10.97722736
69DYRK20.97658785
70MARK10.95572942
71FGFR20.93847519
72KSR10.90825629
73JAK30.90699696
74IRAK10.87658295
75CDC42BPA0.87475733
76PTK20.87454116
77ERBB30.87102359
78MAPKAPK30.86948102
79CAMK2D0.86866158
80PRKD20.86464506
81IKBKB0.86413126
82RET0.85411497
83EPHA40.85339020
84STK380.85321795
85MST40.84848387
86JAK10.84180447
87TNIK0.82681976
88PRKCE0.82565091
89CSNK1G30.80585728
90PDGFRA0.79842362
91GSK3A0.79596358
92PAK40.78751006
93CDK120.77925165
94CSNK1A1L0.77890244
95CSNK1G20.77069086
96ITK0.76814334
97PRKAA10.75926529
98SGK30.75856383
99ROCK10.74579272
100DYRK30.72845874
101CSNK1G10.72591013
102STK110.71947157
103BMPR1B0.70941333
104TESK10.69718545
105ERBB20.69638695
106RPS6KA10.69429922
107KSR20.68418316
108RIPK10.68413404
109CAMK2B0.67372171
110CAMK1G0.65488602
111MAPKAPK50.64394212
112MAPKAPK20.63116182
113EPHA20.61787733
114HCK0.61480785
115MET0.61455897
116FGFR10.59994877
117SYK0.59904446
118MATK0.59732956
119ROCK20.59601574
120RPS6KB20.59594228
121CAMK2A0.59528587
122PIK3CG0.59498860
123ARAF0.59313797
124MAP3K10.59083246
125CDK90.58830505
126WNK10.58515692
127MAP3K70.58431752
128PRKCI0.57744383
129PKN10.57384590
130CSNK1D0.57213936
131MAP2K20.56486039
132ICK0.56301674
133MARK20.55444301
134DDR20.55210957
135PRKCZ0.53056583
136ALK0.52721338
137MAP3K30.52197171
138CSF1R0.50422603
139TBK10.48316263
140MAP2K10.48271310
141GRK10.48081210
142BRAF0.47382969
143MAP2K60.47159105
144PRKG10.47102335
145MAP3K20.47074898
146ERBB40.46418990
147MTOR0.46173420
148CSNK1A10.46062784
149PDGFRB0.44985752
150PRKD30.43165852
151DYRK1A0.43116515
152JAK20.43024785
153SGK10.41777154
154RPS6KA20.40832095
155MOS0.39880382
156AKT20.39843653
157TYK20.39700682
158WNK30.39557799
159CAMK2G0.38173687
160CAMKK10.36712344
161MAPK100.36455401
162MAP4K20.35716593
163ADRBK10.35670881
164RPS6KA30.34888206
165RPS6KB10.33264063

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.65874352
2Insulin secretion_Homo sapiens_hsa049113.25713327
3Thyroid hormone synthesis_Homo sapiens_hsa049183.00915378
4Vitamin B6 metabolism_Homo sapiens_hsa007502.51348544
5B cell receptor signaling pathway_Homo sapiens_hsa046622.36231293
6Synaptic vesicle cycle_Homo sapiens_hsa047212.25269296
7Basal cell carcinoma_Homo sapiens_hsa052172.09987299
8Circadian entrainment_Homo sapiens_hsa047132.08793128
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.02375079
10GABAergic synapse_Homo sapiens_hsa047271.99742054
11Nicotine addiction_Homo sapiens_hsa050331.95101588
12Dorso-ventral axis formation_Homo sapiens_hsa043201.95088300
13Glutamatergic synapse_Homo sapiens_hsa047241.77253443
14Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.70649786
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.70115553
16Hippo signaling pathway_Homo sapiens_hsa043901.68042920
17Primary immunodeficiency_Homo sapiens_hsa053401.67648491
18Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.67603134
19Morphine addiction_Homo sapiens_hsa050321.66184742
20Vibrio cholerae infection_Homo sapiens_hsa051101.63155150
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62889815
22Osteoclast differentiation_Homo sapiens_hsa043801.57567931
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.57109434
24Antigen processing and presentation_Homo sapiens_hsa046121.56490903
25Hedgehog signaling pathway_Homo sapiens_hsa043401.54087721
26Pancreatic cancer_Homo sapiens_hsa052121.52664381
27TGF-beta signaling pathway_Homo sapiens_hsa043501.51908286
28Toxoplasmosis_Homo sapiens_hsa051451.51510497
29Sphingolipid metabolism_Homo sapiens_hsa006001.50103802
30Colorectal cancer_Homo sapiens_hsa052101.49124554
31Cholinergic synapse_Homo sapiens_hsa047251.48177734
32ECM-receptor interaction_Homo sapiens_hsa045121.44038207
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.42388943
34Prolactin signaling pathway_Homo sapiens_hsa049171.38835890
35Salivary secretion_Homo sapiens_hsa049701.38279798
36Small cell lung cancer_Homo sapiens_hsa052221.38106310
37Chronic myeloid leukemia_Homo sapiens_hsa052201.37795296
38MicroRNAs in cancer_Homo sapiens_hsa052061.36572094
39Adherens junction_Homo sapiens_hsa045201.35179787
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34651636
41Wnt signaling pathway_Homo sapiens_hsa043101.34017210
42Serotonergic synapse_Homo sapiens_hsa047261.33700329
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30825454
44cAMP signaling pathway_Homo sapiens_hsa040241.26272598
45Endometrial cancer_Homo sapiens_hsa052131.25207772
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24216027
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.22062971
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.19881265
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17709667
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.16150880
51TNF signaling pathway_Homo sapiens_hsa046681.16145504
52VEGF signaling pathway_Homo sapiens_hsa043701.14805221
53HTLV-I infection_Homo sapiens_hsa051661.13964768
54Axon guidance_Homo sapiens_hsa043601.13292424
55Pancreatic secretion_Homo sapiens_hsa049721.12234603
56Acute myeloid leukemia_Homo sapiens_hsa052211.12129668
57Proteoglycans in cancer_Homo sapiens_hsa052051.12062108
58Melanogenesis_Homo sapiens_hsa049161.12049456
59Collecting duct acid secretion_Homo sapiens_hsa049661.11982522
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11291773
61Estrogen signaling pathway_Homo sapiens_hsa049151.09891438
62Inositol phosphate metabolism_Homo sapiens_hsa005621.08793707
63Leishmaniasis_Homo sapiens_hsa051401.06867287
64T cell receptor signaling pathway_Homo sapiens_hsa046601.05166017
65Pathways in cancer_Homo sapiens_hsa052001.04502465
66Butanoate metabolism_Homo sapiens_hsa006501.04437116
67Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04307463
68Amoebiasis_Homo sapiens_hsa051461.03544719
69Focal adhesion_Homo sapiens_hsa045101.00361591
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00274483
71Protein export_Homo sapiens_hsa030600.99027519
72Chemokine signaling pathway_Homo sapiens_hsa040620.98205775
73Bladder cancer_Homo sapiens_hsa052190.97332022
74GnRH signaling pathway_Homo sapiens_hsa049120.97221880
75Notch signaling pathway_Homo sapiens_hsa043300.96329583
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95586546
77Hematopoietic cell lineage_Homo sapiens_hsa046400.93944794
78Glycosaminoglycan degradation_Homo sapiens_hsa005310.93389103
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93052833
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92689218
81MAPK signaling pathway_Homo sapiens_hsa040100.92535762
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.92338440
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.92135121
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92045497
85Cocaine addiction_Homo sapiens_hsa050300.88835019
86Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88059753
87Bile secretion_Homo sapiens_hsa049760.87956653
88Renin secretion_Homo sapiens_hsa049240.86206085
89Thyroid cancer_Homo sapiens_hsa052160.85087651
90Ovarian steroidogenesis_Homo sapiens_hsa049130.84920119
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.84621326
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84576598
93Viral myocarditis_Homo sapiens_hsa054160.84109620
94Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83994068
95Renal cell carcinoma_Homo sapiens_hsa052110.83377246
96Phototransduction_Homo sapiens_hsa047440.83194486
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.81896686
98Hepatitis B_Homo sapiens_hsa051610.81777301
99Oxytocin signaling pathway_Homo sapiens_hsa049210.81169396
100Calcium signaling pathway_Homo sapiens_hsa040200.80751049
101Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.79983872
102Insulin resistance_Homo sapiens_hsa049310.79501343
103Malaria_Homo sapiens_hsa051440.78811844
104Linoleic acid metabolism_Homo sapiens_hsa005910.78753305
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77421545
106Sulfur metabolism_Homo sapiens_hsa009200.75921055
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74919257
108Protein digestion and absorption_Homo sapiens_hsa049740.74190511
109ErbB signaling pathway_Homo sapiens_hsa040120.73005199
110Apoptosis_Homo sapiens_hsa042100.72671869
111Amphetamine addiction_Homo sapiens_hsa050310.72321078
112FoxO signaling pathway_Homo sapiens_hsa040680.70925037
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70429274
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70406654
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70139569
116Type II diabetes mellitus_Homo sapiens_hsa049300.70015235
117Non-small cell lung cancer_Homo sapiens_hsa052230.69373627
118p53 signaling pathway_Homo sapiens_hsa041150.69240802
119Olfactory transduction_Homo sapiens_hsa047400.67756987
120Long-term potentiation_Homo sapiens_hsa047200.66559095
121Glioma_Homo sapiens_hsa052140.66047410
122Prostate cancer_Homo sapiens_hsa052150.66015843
123Taste transduction_Homo sapiens_hsa047420.65864362
124Phospholipase D signaling pathway_Homo sapiens_hsa040720.65443406
125Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.64045205
126Viral carcinogenesis_Homo sapiens_hsa052030.63715371
127Rap1 signaling pathway_Homo sapiens_hsa040150.63680320
128Glucagon signaling pathway_Homo sapiens_hsa049220.63569839
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63296885
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62816210
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62762945
132Tuberculosis_Homo sapiens_hsa051520.61838444
133cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60284118
134Platelet activation_Homo sapiens_hsa046110.59925676
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.59922661
136Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59616172
137Sphingolipid signaling pathway_Homo sapiens_hsa040710.59412114
138Gastric acid secretion_Homo sapiens_hsa049710.59170121
139Gap junction_Homo sapiens_hsa045400.59086723
140Long-term depression_Homo sapiens_hsa047300.58817254
141Intestinal immune network for IgA production_Homo sapiens_hsa046720.58622756
142Folate biosynthesis_Homo sapiens_hsa007900.57787053
143Circadian rhythm_Homo sapiens_hsa047100.57239171
144Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57222502
145mTOR signaling pathway_Homo sapiens_hsa041500.56400536
146Melanoma_Homo sapiens_hsa052180.56397680
147Ras signaling pathway_Homo sapiens_hsa040140.56233432
148ABC transporters_Homo sapiens_hsa020100.55299879
149beta-Alanine metabolism_Homo sapiens_hsa004100.55224470
150Endocytosis_Homo sapiens_hsa041440.54626751
151Dopaminergic synapse_Homo sapiens_hsa047280.54231279
152Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54025440
153Ether lipid metabolism_Homo sapiens_hsa005650.49919001
154Dilated cardiomyopathy_Homo sapiens_hsa054140.49728582
155Oocyte meiosis_Homo sapiens_hsa041140.49561270
156AMPK signaling pathway_Homo sapiens_hsa041520.49354882
157N-Glycan biosynthesis_Homo sapiens_hsa005100.46931397
158Tight junction_Homo sapiens_hsa045300.45454963
159Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43996936
160Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43699133
161Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42587811
162Alcoholism_Homo sapiens_hsa050340.41440524

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