FAM170A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.66771332
2motile cilium assembly (GO:0044458)9.56587124
3spermatid development (GO:0007286)9.44303047
4piRNA metabolic process (GO:0034587)9.11632939
5cilium movement (GO:0003341)8.41971220
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.19119747
7male meiosis (GO:0007140)8.15452460
8synaptonemal complex organization (GO:0070193)7.82620064
9regulation of cilium movement (GO:0003352)7.78264879
10synaptonemal complex assembly (GO:0007130)7.61346521
11single fertilization (GO:0007338)7.55027709
12sperm capacitation (GO:0048240)6.81861314
13negative regulation of inclusion body assembly (GO:0090084)6.56573250
14fertilization (GO:0009566)6.41474734
15spermatogenesis (GO:0007283)6.33901978
16male gamete generation (GO:0048232)6.31790090
17microtubule depolymerization (GO:0007019)5.92824541
18DNA methylation involved in gamete generation (GO:0043046)5.89873830
19gamete generation (GO:0007276)5.80766483
20organic cation transport (GO:0015695)5.68033625
21male meiosis I (GO:0007141)5.39969256
22regulation of inclusion body assembly (GO:0090083)5.38175899
23germ cell development (GO:0007281)5.35606926
24chromosome organization involved in meiosis (GO:0070192)5.33711495
25cellular process involved in reproduction in multicellular organism (GO:0022412)5.30846450
26calcium ion-dependent exocytosis (GO:0017156)5.22271851
27ventricular system development (GO:0021591)5.22163158
28spermatid nucleus differentiation (GO:0007289)4.99316471
29cell recognition (GO:0008037)4.97016228
30meiotic nuclear division (GO:0007126)4.77527514
31seminiferous tubule development (GO:0072520)4.75920508
32regulation of microtubule-based movement (GO:0060632)4.55902863
33multicellular organismal reproductive process (GO:0048609)4.55378443
34microtubule severing (GO:0051013)4.52688690
35meiosis I (GO:0007127)4.34372881
36glycerol ether metabolic process (GO:0006662)4.32413511
37left/right pattern formation (GO:0060972)4.14540290
38chromosome condensation (GO:0030261)4.13852049
39meiotic cell cycle (GO:0051321)4.11186405
40ether metabolic process (GO:0018904)3.99406345
41DNA packaging (GO:0006323)3.94564468
42chaperone-mediated protein complex assembly (GO:0051131)3.90980433
43protein localization to cilium (GO:0061512)3.84714741
44monoubiquitinated protein deubiquitination (GO:0035520)3.81005027
45genitalia morphogenesis (GO:0035112)3.79415514
46single strand break repair (GO:0000012)3.76953312
47multicellular organismal development (GO:0007275)3.68112537
48sexual reproduction (GO:0019953)3.65868362
49protein K11-linked deubiquitination (GO:0035871)3.44500310
50centriole assembly (GO:0098534)3.35589181
51protein polyglutamylation (GO:0018095)3.32746938
52gene silencing by RNA (GO:0031047)3.27000762
53intraciliary transport (GO:0042073)3.24406649
54synapsis (GO:0007129)3.19806432
55carnitine transport (GO:0015879)3.14059599
56amino-acid betaine transport (GO:0015838)3.14059599
57alditol metabolic process (GO:0019400)3.13899554
58meiotic cell cycle process (GO:1903046)3.12851481
59lactate metabolic process (GO:0006089)3.10427048
60regulation of spindle checkpoint (GO:0090231)3.09589436
61sequestering of actin monomers (GO:0042989)3.08301525
62microtubule polymerization or depolymerization (GO:0031109)3.08061410
63axoneme assembly (GO:0035082)3.07910626
64nucleoside diphosphate phosphorylation (GO:0006165)3.07025672
65microtubule-based movement (GO:0007018)3.06858042
66carnitine transmembrane transport (GO:1902603)3.05955096
67polyol catabolic process (GO:0046174)3.03614703
68protein refolding (GO:0042026)3.01854118
69cilium organization (GO:0044782)2.99415226
70glycolytic process (GO:0006096)2.90482304
71negative regulation of organelle assembly (GO:1902116)2.90166163
72nucleus organization (GO:0006997)2.88937424
73cilium assembly (GO:0042384)2.86540836
74GTP biosynthetic process (GO:0006183)2.84951482
75mitotic sister chromatid cohesion (GO:0007064)2.84235011
76cilium morphogenesis (GO:0060271)2.82628066
77cellular component assembly involved in morphogenesis (GO:0010927)2.82115584
78centriole replication (GO:0007099)2.79073947
79glycerol metabolic process (GO:0006071)2.75781133
80regulation of centriole replication (GO:0046599)2.71805952
81interferon-gamma secretion (GO:0072643)2.63990869
82regulation of meiosis I (GO:0060631)2.63133670
83gene silencing (GO:0016458)2.62035547
84UTP biosynthetic process (GO:0006228)2.52794625
85nuclear pore complex assembly (GO:0051292)2.43804168
86peptidyl-glutamic acid modification (GO:0018200)2.39822936
87fusion of sperm to egg plasma membrane (GO:0007342)13.7640374
88sperm motility (GO:0030317)13.0047404
89cilium or flagellum-dependent cell motility (GO:0001539)12.4899646
90cell wall macromolecule catabolic process (GO:0016998)12.4116404
91cell wall macromolecule metabolic process (GO:0044036)12.4116404
92acrosome assembly (GO:0001675)11.6562229
93sperm-egg recognition (GO:0035036)11.4933250
94multicellular organism reproduction (GO:0032504)11.3845789
95acrosome reaction (GO:0007340)11.2521050
96plasma membrane fusion (GO:0045026)10.4871766
97binding of sperm to zona pellucida (GO:0007339)10.4102817
98axonemal dynein complex assembly (GO:0070286)10.3572974
99cell-cell recognition (GO:0009988)10.2870162
100epithelial cilium movement (GO:0003351)10.0962841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.81674260
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.19701372
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.50079235
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.76050471
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.64347660
6FLI1_27457419_Chip-Seq_LIVER_Mouse2.49202322
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.28011704
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.18196269
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.11766898
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.11752306
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.09825591
12ZNF274_21170338_ChIP-Seq_K562_Hela2.09028865
13VDR_22108803_ChIP-Seq_LS180_Human2.08269600
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.08122387
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.05452342
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse10.3329335
17ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83133581
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76570503
19TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68774989
20STAT1_17558387_ChIP-Seq_HELA_Human1.66326384
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65568284
22KAP1_22055183_ChIP-Seq_ESCs_Mouse1.63563070
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62963831
24CBX2_27304074_Chip-Seq_ESCs_Mouse1.60246464
25KDM2B_26808549_Chip-Seq_REH_Human1.54019175
26MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.53776565
27TAL1_26923725_Chip-Seq_HPCs_Mouse1.53342087
28NFE2_27457419_Chip-Seq_LIVER_Mouse1.53181540
29GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52727353
30WDR5_24793694_ChIP-Seq_LNCAP_Human1.48955945
31FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48418830
32SOX2_22085726_ChIP-Seq_NPCs_Mouse1.47247668
33SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47118825
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.39349384
35GATA3_21867929_ChIP-Seq_CD8_Mouse1.38400548
36CBP_20019798_ChIP-Seq_JUKART_Human1.34914779
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34914779
38GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30432755
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28576085
40* REST_21632747_ChIP-Seq_MESCs_Mouse1.26114760
41LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.25896104
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.23841554
43P53_21459846_ChIP-Seq_SAOS-2_Human1.22708525
44FLI1_21867929_ChIP-Seq_TH2_Mouse1.22272295
45GATA3_21867929_ChIP-Seq_TH1_Mouse1.21270992
46NANOG_18555785_Chip-Seq_ESCs_Mouse1.20817466
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20552462
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19356567
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.17983167
50EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17407500
51PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.16771443
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16313289
53GF1_26923725_Chip-Seq_HPCs_Mouse1.16158910
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15594776
55FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14971157
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14543456
57OCT4_18555785_Chip-Seq_ESCs_Mouse1.13756582
58CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13298163
59SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.12663577
60P53_22387025_ChIP-Seq_ESCs_Mouse1.12186794
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10538712
62RAD21_21589869_ChIP-Seq_MESCs_Mouse1.09813890
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.09654138
64TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07833889
65POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07833889
66PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07315924
67CMYC_18555785_Chip-Seq_ESCs_Mouse1.07003660
68P300_18555785_Chip-Seq_ESCs_Mouse1.05768456
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04467218
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.03848358
71NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03235851
72KLF4_18555785_Chip-Seq_ESCs_Mouse1.03094181
73OCT4_21477851_ChIP-Seq_ESCs_Mouse1.02768118
74EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01124436
75RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00555111
76ESET_19884257_ChIP-Seq_ESCs_Mouse0.99540449
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.99094147
78SPI1_26923725_Chip-Seq_HPCs_Mouse0.99016717
79ESRRB_18555785_Chip-Seq_ESCs_Mouse0.98396112
80PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97395623
81STAT3_18555785_Chip-Seq_ESCs_Mouse0.97336739
82SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96803555
83TAF15_26573619_Chip-Seq_HEK293_Human0.96079810
84SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95311589
85ERG_20517297_ChIP-Seq_VCAP_Human0.93815580
86PU1_27457419_Chip-Seq_LIVER_Mouse0.93461019
87RNF2_27304074_Chip-Seq_NSC_Mouse0.93055141
88CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.92744114
89RXRA_24833708_ChIP-Seq_LIVER_Mouse0.92431187
90RARA_24833708_ChIP-Seq_LIVER_Mouse0.90681557
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.90012951
92SOX2_18555785_Chip-Seq_ESCs_Mouse0.89895414
93YY1_22570637_ChIP-Seq_MALME-3M_Human0.89404479
94NFYB_21822215_ChIP-Seq_K562_Human0.89229120
95MYC_27129775_Chip-Seq_CORNEA_Mouse0.89201883
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88842226
97LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.88688400
98PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88211085
99EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.86968683
100* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86078874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.09410229
2MP0001929_abnormal_gametogenesis5.60075556
3MP0008877_abnormal_DNA_methylation4.77843815
4MP0002210_abnormal_sex_determination3.69573540
5MP0002161_abnormal_fertility/fecundity3.28871413
6MP0001145_abnormal_male_reproductive3.10774086
7MP0000653_abnormal_sex_gland2.69703605
8MP0002653_abnormal_ependyma_morphology2.65167663
9MP0005670_abnormal_white_adipose2.20841346
10MP0005410_abnormal_fertilization16.0119341
11MP0002160_abnormal_reproductive_system1.84532616
12MP0005623_abnormal_meninges_morphology1.84042986
13MP0003646_muscle_fatigue1.47739672
14MP0008057_abnormal_DNA_replication1.39287180
15MP0004233_abnormal_muscle_weight1.34895805
16MP0002282_abnormal_trachea_morphology1.21474560
17MP0008058_abnormal_DNA_repair1.19991798
18MP0002102_abnormal_ear_morphology1.14913289
19MP0005647_abnormal_sex_gland1.13472005
20MP0001765_abnormal_ion_homeostasis1.07639900
21MP0009046_muscle_twitch1.00690895
22MP0001984_abnormal_olfaction0.98647261
23MP0005389_reproductive_system_phenotype0.94882219
24MP0003011_delayed_dark_adaptation0.94725412
25MP0010094_abnormal_chromosome_stability0.87163292
26MP0002234_abnormal_pharynx_morphology0.85403716
27MP0008995_early_reproductive_senescence0.82800992
28MP0000569_abnormal_digit_pigmentation0.59345014
29MP0003786_premature_aging0.56918512
30MP0005636_abnormal_mineral_homeostasis0.56182725
31MP0000358_abnormal_cell_content/0.53638833
32MP0003878_abnormal_ear_physiology0.53210946
33MP0005377_hearing/vestibular/ear_phenot0.53210946
34MP0003115_abnormal_respiratory_system0.51711587
35MP0005551_abnormal_eye_electrophysiolog0.49823026
36MP0003111_abnormal_nucleus_morphology0.49814503
37MP0005253_abnormal_eye_physiology0.48698008
38MP0008007_abnormal_cellular_replicative0.48441095
39MP0002928_abnormal_bile_duct0.45943175
40MP0003699_abnormal_female_reproductive0.45587597
41MP0005666_abnormal_adipose_tissue0.44382250
42MP0005397_hematopoietic_system_phenotyp0.43500871
43MP0001545_abnormal_hematopoietic_system0.43500871
44MP0002736_abnormal_nociception_after0.42666901
45MP0009278_abnormal_bone_marrow0.41952488
46MP0004036_abnormal_muscle_relaxation0.41500165
47MP0004019_abnormal_vitamin_homeostasis0.41490117
48MP0001119_abnormal_female_reproductive0.41280865
49MP0001324_abnormal_eye_pigmentation0.41251819
50MP0002269_muscular_atrophy0.39641983
51MP0003950_abnormal_plasma_membrane0.39015346
52MP0006072_abnormal_retinal_apoptosis0.38840627
53MP0001764_abnormal_homeostasis0.38809897
54MP0003329_amyloid_beta_deposits0.38289161
55MP0004808_abnormal_hematopoietic_stem0.35676329
56MP0006036_abnormal_mitochondrial_physio0.34847966
57MP0001293_anophthalmia0.34547328
58MP0005391_vision/eye_phenotype0.33070339
59MP0004133_heterotaxia0.32099711
60MP0010307_abnormal_tumor_latency0.31769111
61MP0002971_abnormal_brown_adipose0.27932541
62MP0004742_abnormal_vestibular_system0.27716852
63MP0009115_abnormal_fat_cell0.27175176
64MP0004134_abnormal_chest_morphology0.25715703
65MP0003633_abnormal_nervous_system0.24438940
66MP0001730_embryonic_growth_arrest0.23952756
67MP0004811_abnormal_neuron_physiology0.22603632
68MP0003861_abnormal_nervous_system0.22052148
69MP0002108_abnormal_muscle_morphology0.21926856
70MP0003045_fibrosis0.21803495
71MP0001968_abnormal_touch/_nociception0.20537834
72MP0002152_abnormal_brain_morphology0.20450234
73MP0003879_abnormal_hair_cell0.19807367
74MP0004043_abnormal_pH_regulation0.19593803
75MP0002139_abnormal_hepatobiliary_system0.19335193
76MP0001727_abnormal_embryo_implantation0.19177240
77MP0003195_calcinosis0.18045813
78MP0000313_abnormal_cell_death0.17633905
79MP0006035_abnormal_mitochondrial_morpho0.17159103
80MP0003631_nervous_system_phenotype0.16954170
81MP0002169_no_abnormal_phenotype0.16645582
82MP0002873_normal_phenotype0.16379667
83MP0003942_abnormal_urinary_system0.16091901
84MP0002229_neurodegeneration0.15771018
85MP0000534_abnormal_ureter_morphology0.15633502
86MP0001661_extended_life_span0.15575656
87MP0000604_amyloidosis0.14638324
88MP0001440_abnormal_grooming_behavior0.14195615
89MP0005195_abnormal_posterior_eye0.14119740
90MP0003077_abnormal_cell_cycle0.13290359
91MP0001919_abnormal_reproductive_system0.13015873
92MP0002092_abnormal_eye_morphology0.12304225
93MP0002084_abnormal_developmental_patter0.12239759
94MP0008961_abnormal_basal_metabolism0.12212787
95MP0000001_mammalian_phenotype0.11811582
96MP0000427_abnormal_hair_cycle0.11618910
97MP0000751_myopathy0.11539856
98MP0003948_abnormal_gas_homeostasis0.10733502
99MP0002168_other_aberrant_phenotype0.10513128
100MP0003936_abnormal_reproductive_system0.10440789

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.49431301
2Abnormal respiratory epithelium morphology (HP:0012253)9.28447787
3Abnormal respiratory motile cilium morphology (HP:0005938)9.28447787
4Rhinitis (HP:0012384)7.80823131
5Abnormal ciliary motility (HP:0012262)7.68275330
6Chronic bronchitis (HP:0004469)7.44604800
7Infertility (HP:0000789)6.51549804
8Nasal polyposis (HP:0100582)6.39573791
9Abnormality of the nasal mucosa (HP:0000433)5.24580216
10Bronchiectasis (HP:0002110)4.52077088
11Bronchitis (HP:0012387)4.46393865
12Nephronophthisis (HP:0000090)4.21064513
13Male infertility (HP:0003251)3.70065864
14Recurrent sinusitis (HP:0011108)3.46962305
15Recurrent otitis media (HP:0000403)3.24596123
16Abnormality of the renal medulla (HP:0100957)3.21594282
17Abnormal spermatogenesis (HP:0008669)3.05633405
18Tubulointerstitial nephritis (HP:0001970)2.98799029
19Gonadotropin excess (HP:0000837)2.77279128
20Medial flaring of the eyebrow (HP:0010747)2.73674995
21Abnormality of the lower motor neuron (HP:0002366)2.52238950
22Molar tooth sign on MRI (HP:0002419)2.50379094
23Abnormality of midbrain morphology (HP:0002418)2.50379094
24Recurrent bronchitis (HP:0002837)2.47586575
25Tubular atrophy (HP:0000092)2.45261855
26Tubulointerstitial abnormality (HP:0001969)2.37466450
27Impulsivity (HP:0100710)2.26019928
28Azoospermia (HP:0000027)2.19220765
29Amyotrophic lateral sclerosis (HP:0007354)2.02980536
30Fibular hypoplasia (HP:0003038)2.01568521
31Postaxial foot polydactyly (HP:0001830)2.00724621
32Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.4176729
33Absent/shortened dynein arms (HP:0200106)13.3345634
34Dynein arm defect of respiratory motile cilia (HP:0012255)13.3345634
35Stage 5 chronic kidney disease (HP:0003774)1.95220892
36Polydipsia (HP:0001959)1.83456003
37Abnormal drinking behavior (HP:0030082)1.83456003
38Congenital hepatic fibrosis (HP:0002612)1.80272900
39Hypoplasia of the capital femoral epiphysis (HP:0003090)1.78783511
40Cholecystitis (HP:0001082)1.77674970
41Abnormal gallbladder physiology (HP:0012438)1.77674970
42Tubulointerstitial fibrosis (HP:0005576)1.76925926
43Abnormality of the renal cortex (HP:0011035)1.72807081
44Abnormality of the dental root (HP:0006486)1.70215508
45Taurodontia (HP:0000679)1.70215508
46Abnormality of permanent molar morphology (HP:0011071)1.70215508
47Spastic tetraparesis (HP:0001285)1.68532274
48Impaired proprioception (HP:0010831)1.67611300
49Congenital primary aphakia (HP:0007707)1.67206452
50Gait imbalance (HP:0002141)1.66781419
51Abnormality of renal excretion (HP:0011036)1.65149335
52Chronic sinusitis (HP:0011109)1.64311129
53Oculomotor apraxia (HP:0000657)1.61577307
54Heterotopia (HP:0002282)1.61376800
55Facial cleft (HP:0002006)1.61227938
56Short ribs (HP:0000773)1.59515380
57Renal dysplasia (HP:0000110)1.58680668
58Abnormality of molar (HP:0011077)1.58476684
59Abnormality of molar morphology (HP:0011070)1.58476684
60Postaxial hand polydactyly (HP:0001162)1.57606010
61Dyschromatopsia (HP:0007641)1.55585614
62Abnormality of the dental pulp (HP:0006479)1.55446609
63Abnormality of dentin (HP:0010299)1.55142079
64Absent frontal sinuses (HP:0002688)1.52914578
65Supernumerary spleens (HP:0009799)1.49006825
66Aplasia/Hypoplasia of the lens (HP:0008063)1.46455743
67Bell-shaped thorax (HP:0001591)1.45422353
68Microglossia (HP:0000171)1.45251517
69Nephrogenic diabetes insipidus (HP:0009806)1.43693759
70Bile duct proliferation (HP:0001408)1.43252859
71Abnormal biliary tract physiology (HP:0012439)1.43252859
72J-shaped sella turcica (HP:0002680)1.42180538
73Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40405848
74Absent epiphyses (HP:0010577)1.40405848
75Decreased central vision (HP:0007663)1.37961382
76Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.35917140
77Choroideremia (HP:0001139)1.35362290
78Upper motor neuron abnormality (HP:0002127)1.34895572
79Cystic liver disease (HP:0006706)1.32392029
80Short thorax (HP:0010306)1.30468850
81Abnormality of ocular smooth pursuit (HP:0000617)1.28434683
82Asymmetric septal hypertrophy (HP:0001670)1.28366481
83Aplasia/Hypoplasia of the tongue (HP:0010295)1.28055483
84Abnormal urine output (HP:0012590)1.27387661
85Median cleft lip (HP:0000161)1.27049791
86Deformed sella turcica (HP:0002681)1.26578739
87Aplasia/Hypoplasia of the fibula (HP:0006492)1.25426911
88Vaginal atresia (HP:0000148)1.25310869
89Poor coordination (HP:0002370)1.24792146
90Broad distal phalanx of finger (HP:0009836)1.22769962
91Genital tract atresia (HP:0001827)1.22761470
92Nephropathy (HP:0000112)1.22669353
93Pancreatic fibrosis (HP:0100732)1.21357356
94Vascular calcification (HP:0004934)1.21125134
95Cerebellar dysplasia (HP:0007033)1.20703891
96Bundle branch block (HP:0011710)1.18917596
97Easy fatigability (HP:0003388)1.17326896
98Breast carcinoma (HP:0003002)1.15023283
99Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.14345943
100Fatigable weakness (HP:0003473)1.14163589

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.18948736
2PDK39.18948736
3PDK25.96098740
4TESK14.77179941
5PRKD33.84411010
6ICK3.49382487
7WNK42.19495270
8PTK2B2.15024734
9STK392.14320687
10PNCK2.10440299
11NEK21.69669356
12STK381.42369251
13DYRK1B1.09384007
14PDK11.02721175
15WNK10.94034616
16MAPK150.92964914
17IRAK10.91986663
18TYRO30.81279742
19CCNB10.78592439
20PASK0.77692175
21STK30.74642020
22DYRK30.72906780
23TTK0.59006843
24LMTK20.58181985
25PINK10.55062878
26CHEK20.54341769
27CDC70.52445795
28PLK40.51662003
29CAMK1G0.50391724
30TESK20.47152997
31PDPK10.45808153
32MAP2K60.44541575
33CHEK10.44299525
34WEE10.42214061
35STK38L0.40036091
36RIPK40.36433491
37PRKCG0.35809365
38ATR0.35803993
39MUSK0.34603184
40EEF2K0.34191632
41NTRK20.33131642
42IRAK20.31663100
43ATM0.29409596
44PAK10.28977047
45MAPKAPK50.27610426
46CDK120.25160924
47MTOR0.24178351
48BMPR1B0.22370057
49CAMKK10.22178203
50PLK10.19013425
51PAK20.18221584
52PRKAA10.17352628
53RPS6KB10.16655057
54MARK20.13012547
55BRSK20.12551655
56PRKCZ0.10945202
57MAP3K100.10105144
58PRKCQ0.09882216
59NEK60.08565097
60CDK150.08187953
61BRAF0.06865511
62CSF1R0.06596992
63CSNK2A10.06424064
64BRSK10.06245149
65WNK30.06101690
66CDK180.05748936
67CSNK1D0.05648587
68PRKG20.05259002
69PRKACG0.05181109
70PRKG10.05109987
71STK110.05079937
72CDK11A0.04685876
73YES10.04562265
74GSK3B0.04173429
75RPS6KA10.03778670
76MARK30.03636738
77CAMK2A0.03359586
78BUB10.03248775
79PKN10.03084419
80CDK20.02908168
81CDK10.02521064
82CDK140.01980425
83PRKCB0.01527673
84PAK40.01188878
85CSNK2A20.00660701
86MAPK80.00519052
87EGFR0.00156411
88CDK4-0.0399521
89STK10-0.0388024
90MAP3K5-0.0355612
91PRKCD-0.0313576
92PRKACA-0.0240575
93RPS6KA3-0.0235533
94PDGFRB-0.0173299
95ZAP70-0.0135907
96MAP3K4-0.0124407
97PRKCA-0.0054512
98PRKDC-0.0048923
99PRKACB-0.0042994
100CDK3-0.0007704

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.53662062
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39182325
3Pyruvate metabolism_Homo sapiens_hsa006204.17994604
4Fatty acid biosynthesis_Homo sapiens_hsa000613.78916860
5Propanoate metabolism_Homo sapiens_hsa006403.29056449
6Glucagon signaling pathway_Homo sapiens_hsa049222.81129438
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76311163
8Linoleic acid metabolism_Homo sapiens_hsa005912.66733242
9Basal transcription factors_Homo sapiens_hsa030222.55920832
10Selenocompound metabolism_Homo sapiens_hsa004502.38766742
11Dorso-ventral axis formation_Homo sapiens_hsa043202.19714252
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.03754085
13Pentose phosphate pathway_Homo sapiens_hsa000302.02669705
14Glycerolipid metabolism_Homo sapiens_hsa005612.01171954
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.97899274
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.90612252
17Oocyte meiosis_Homo sapiens_hsa041141.90058377
18Fanconi anemia pathway_Homo sapiens_hsa034601.89112703
19Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.79734555
20Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.69662229
21PPAR signaling pathway_Homo sapiens_hsa033201.66348595
22Amphetamine addiction_Homo sapiens_hsa050311.56646497
23Huntingtons disease_Homo sapiens_hsa050161.49789632
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49076644
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.46432676
26Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.41201591
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.40089946
28Carbon metabolism_Homo sapiens_hsa012001.34674114
29Fructose and mannose metabolism_Homo sapiens_hsa000511.33091341
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.31907642
31Cardiac muscle contraction_Homo sapiens_hsa042601.30972664
32Renin secretion_Homo sapiens_hsa049241.21986342
33Ether lipid metabolism_Homo sapiens_hsa005651.21854626
34Fat digestion and absorption_Homo sapiens_hsa049751.19415626
35Mineral absorption_Homo sapiens_hsa049781.19325653
36Fatty acid degradation_Homo sapiens_hsa000711.13726185
37Fatty acid metabolism_Homo sapiens_hsa012121.08556533
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.07877826
39Purine metabolism_Homo sapiens_hsa002301.07012464
40mRNA surveillance pathway_Homo sapiens_hsa030151.05085079
41Antigen processing and presentation_Homo sapiens_hsa046121.00612999
42RNA transport_Homo sapiens_hsa030130.93542707
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91513193
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87955670
45Biosynthesis of amino acids_Homo sapiens_hsa012300.85960251
46Hedgehog signaling pathway_Homo sapiens_hsa043400.84650836
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84528901
48Glutathione metabolism_Homo sapiens_hsa004800.82357285
49Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81402738
50Collecting duct acid secretion_Homo sapiens_hsa049660.81288791
51Long-term potentiation_Homo sapiens_hsa047200.78622058
52ABC transporters_Homo sapiens_hsa020100.75972480
53Insulin secretion_Homo sapiens_hsa049110.75308917
54Chemical carcinogenesis_Homo sapiens_hsa052040.69803544
55Calcium signaling pathway_Homo sapiens_hsa040200.68214532
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67337057
57Estrogen signaling pathway_Homo sapiens_hsa049150.66300814
58Arachidonic acid metabolism_Homo sapiens_hsa005900.66057712
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63318901
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61024861
61Inositol phosphate metabolism_Homo sapiens_hsa005620.58960852
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.58612816
63Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55677583
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.54707403
65Bile secretion_Homo sapiens_hsa049760.50540910
66Thyroid hormone synthesis_Homo sapiens_hsa049180.47618741
67Legionellosis_Homo sapiens_hsa051340.46663086
68N-Glycan biosynthesis_Homo sapiens_hsa005100.45919157
69Systemic lupus erythematosus_Homo sapiens_hsa053220.44574128
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.43472351
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43297859
72Synaptic vesicle cycle_Homo sapiens_hsa047210.42262143
73Metabolic pathways_Homo sapiens_hsa011000.41697358
74VEGF signaling pathway_Homo sapiens_hsa043700.40652311
75Protein digestion and absorption_Homo sapiens_hsa049740.37453675
76Endocytosis_Homo sapiens_hsa041440.36157100
77AMPK signaling pathway_Homo sapiens_hsa041520.35140990
78Pancreatic secretion_Homo sapiens_hsa049720.34061781
79Salivary secretion_Homo sapiens_hsa049700.31996006
80Circadian entrainment_Homo sapiens_hsa047130.31963922
81Renin-angiotensin system_Homo sapiens_hsa046140.31855984
82Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31111202
83Taste transduction_Homo sapiens_hsa047420.30303309
84Pyrimidine metabolism_Homo sapiens_hsa002400.29691373
85cAMP signaling pathway_Homo sapiens_hsa040240.29324155
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25086455
87Gastric acid secretion_Homo sapiens_hsa049710.22725968
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.22664259
89Wnt signaling pathway_Homo sapiens_hsa043100.21868062
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21025964
91B cell receptor signaling pathway_Homo sapiens_hsa046620.20722757
92Basal cell carcinoma_Homo sapiens_hsa052170.20191387
93Retinol metabolism_Homo sapiens_hsa008300.19961764
94Alcoholism_Homo sapiens_hsa050340.16491543
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.14658527
96Cocaine addiction_Homo sapiens_hsa050300.12715416
97Homologous recombination_Homo sapiens_hsa034400.11161650
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.10005988
99Glutamatergic synapse_Homo sapiens_hsa047240.08490829
100Sulfur metabolism_Homo sapiens_hsa009200.07864651

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