FAM170B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.93305103
2spermatid development (GO:0007286)9.87791947
3epithelial cilium movement (GO:0003351)9.87420012
4motile cilium assembly (GO:0044458)9.74536095
5reproduction (GO:0000003)9.39776872
6regulation of cilium movement (GO:0003352)8.78634315
7cilium or flagellum-dependent cell motility (GO:0001539)8.75576260
8cilium movement (GO:0003341)7.93626823
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.45381170
10negative regulation of inclusion body assembly (GO:0090084)7.36346190
11single fertilization (GO:0007338)7.36037065
12sperm capacitation (GO:0048240)7.24287160
13synaptonemal complex organization (GO:0070193)7.09919174
14piRNA metabolic process (GO:0034587)6.97202195
15synaptonemal complex assembly (GO:0007130)6.92324579
16male meiosis (GO:0007140)6.86637939
17spermatogenesis (GO:0007283)6.82311335
18male gamete generation (GO:0048232)6.79799936
19organic cation transport (GO:0015695)6.78118159
20microtubule depolymerization (GO:0007019)6.63478078
21fertilization (GO:0009566)6.27606430
22gamete generation (GO:0007276)6.24672325
23regulation of inclusion body assembly (GO:0090083)6.11233729
24calcium ion-dependent exocytosis (GO:0017156)5.72259346
25germ cell development (GO:0007281)5.47296432
26cellular process involved in reproduction in multicellular organism (GO:0022412)5.40538109
27chromosome condensation (GO:0030261)5.34906270
28regulation of microtubule-based movement (GO:0060632)5.16082064
29spermatid nucleus differentiation (GO:0007289)5.15656599
30DNA packaging (GO:0006323)5.08702205
31ventricular system development (GO:0021591)5.06753965
32cell recognition (GO:0008037)5.03331504
33glycerol ether metabolic process (GO:0006662)4.98513833
34multicellular organismal reproductive process (GO:0048609)4.90999292
35microtubule severing (GO:0051013)4.79643916
36male meiosis I (GO:0007141)4.76908602
37chromosome organization involved in meiosis (GO:0070192)4.68922274
38seminiferous tubule development (GO:0072520)4.62291827
39ether metabolic process (GO:0018904)4.60730862
40DNA methylation involved in gamete generation (GO:0043046)4.49404298
41sexual reproduction (GO:0019953)4.46888426
42left/right pattern formation (GO:0060972)4.44418604
43single strand break repair (GO:0000012)4.24520630
44meiotic nuclear division (GO:0007126)4.14099161
45chaperone-mediated protein complex assembly (GO:0051131)4.11119179
46multicellular organismal development (GO:0007275)3.97764914
47meiosis I (GO:0007127)3.79467657
48sequestering of actin monomers (GO:0042989)3.67200190
49genitalia morphogenesis (GO:0035112)3.52141662
50protein polyglutamylation (GO:0018095)3.50736483
51protein K11-linked deubiquitination (GO:0035871)3.46073120
52regulation of spindle checkpoint (GO:0090231)3.42705754
53microtubule polymerization or depolymerization (GO:0031109)3.37287339
54meiotic cell cycle (GO:0051321)3.34562927
55protein refolding (GO:0042026)3.33434004
56monoubiquitinated protein deubiquitination (GO:0035520)3.30887699
57amino-acid betaine transport (GO:0015838)3.20190308
58carnitine transport (GO:0015879)3.20190308
59interferon-gamma secretion (GO:0072643)3.19741304
60protein localization to cilium (GO:0061512)3.19658788
61glycolytic process (GO:0006096)3.10311686
62nucleus organization (GO:0006997)3.08380812
63mitotic sister chromatid cohesion (GO:0007064)3.05282135
64carnitine transmembrane transport (GO:1902603)3.03201307
65polyol catabolic process (GO:0046174)3.01591088
66RNA localization (GO:0006403)2.99020014
67RNA destabilization (GO:0050779)2.97659766
68alditol metabolic process (GO:0019400)2.97407886
69nucleoside diphosphate phosphorylation (GO:0006165)2.97153050
70positive regulation of macrophage activation (GO:0043032)2.97021875
71polyamine biosynthetic process (GO:0006596)2.85093034
72cilium organization (GO:0044782)2.79123061
73meiotic cell cycle process (GO:1903046)2.72783417
74regulation of cilium assembly (GO:1902017)2.71168796
75synapsis (GO:0007129)2.70496144
76cilium morphogenesis (GO:0060271)2.68746683
77cilium assembly (GO:0042384)2.68531538
78microtubule-based movement (GO:0007018)2.68299417
79chromatin silencing (GO:0006342)2.68132079
80GTP biosynthetic process (GO:0006183)2.66984146
81cellular component assembly involved in morphogenesis (GO:0010927)2.64840322
82axoneme assembly (GO:0035082)2.62709648
83intraciliary transport (GO:0042073)2.54437698
84peptidyl-glutamic acid modification (GO:0018200)2.52442732
85negative regulation of organelle assembly (GO:1902116)2.52013373
86glycerol metabolic process (GO:0006071)2.48287050
87mitochondrion degradation (GO:0000422)2.48065598
88lactate metabolic process (GO:0006089)2.45005442
89protein-DNA complex disassembly (GO:0032986)2.44574839
90sperm motility (GO:0030317)14.1300303
91cell wall macromolecule catabolic process (GO:0016998)13.2551182
92cell wall macromolecule metabolic process (GO:0044036)13.2551182
93fusion of sperm to egg plasma membrane (GO:0007342)13.1948244
94acrosome reaction (GO:0007340)12.5417967
95sperm-egg recognition (GO:0035036)11.6370176
96acrosome assembly (GO:0001675)11.4078631
97multicellular organism reproduction (GO:0032504)10.8060214
98binding of sperm to zona pellucida (GO:0007339)10.6024330
99cell-cell recognition (GO:0009988)10.4180971
100plasma membrane fusion (GO:0045026)10.0558563

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.41872835
2EZH2_22144423_ChIP-Seq_EOC_Human4.09518777
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.94506946
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.08258199
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95964643
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.86733560
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78445632
8VDR_22108803_ChIP-Seq_LS180_Human2.45307394
9GATA1_26923725_Chip-Seq_HPCs_Mouse2.23248939
10CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.22695727
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.12312497
12EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.07899861
13ZNF274_21170338_ChIP-Seq_K562_Hela1.95421318
14FLI1_27457419_Chip-Seq_LIVER_Mouse1.92861891
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.77736818
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77366669
17KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.76940403
18FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76757495
19STAT1_17558387_ChIP-Seq_HELA_Human1.73314838
20MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68537262
21TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.66903216
22SOX2_22085726_ChIP-Seq_NPCs_Mouse1.64521422
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60269040
24GATA3_21867929_ChIP-Seq_CD8_Mouse1.58130651
25GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.52783445
26WDR5_24793694_ChIP-Seq_LNCAP_Human1.51277851
27FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.46056590
28KDM2B_26808549_Chip-Seq_REH_Human1.44847741
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44450210
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.43697660
31PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.42949419
32RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.40800139
33KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40679957
34CBP_20019798_ChIP-Seq_JUKART_Human1.37210916
35IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37210916
36P53_21459846_ChIP-Seq_SAOS-2_Human1.36444484
37LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.34328013
38REST_21632747_ChIP-Seq_MESCs_Mouse1.31984067
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30808616
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.30721398
41SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.29950624
42GATA3_21867929_ChIP-Seq_TH1_Mouse1.28284379
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.26939960
44RAD21_21589869_ChIP-Seq_MESCs_Mouse1.24777338
45GF1_26923725_Chip-Seq_HPCs_Mouse1.23243189
46NFE2_27457419_Chip-Seq_LIVER_Mouse1.20974212
47CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19323711
48FLI1_21867929_ChIP-Seq_TH2_Mouse1.18854166
49TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17988270
50SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17836220
51CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15899382
52TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15551105
53SPI1_26923725_Chip-Seq_HPCs_Mouse1.15103786
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.14408283
55ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.14042819
56SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13519059
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12965477
58RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11453864
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.10348077
60RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10014673
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08786270
62TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08786270
63SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08003468
64MYC_27129775_Chip-Seq_CORNEA_Mouse1.07999407
65EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06466610
66ESET_19884257_ChIP-Seq_ESCs_Mouse1.05454449
67ERG_20517297_ChIP-Seq_VCAP_Human1.05024444
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.04334480
69GATA1_19941827_ChIP-Seq_MEL86_Mouse1.04287593
70YY1_22570637_ChIP-Seq_MALME-3M_Human1.04061217
71RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04058178
72EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.03890712
73JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.02788521
74RARA_24833708_ChIP-Seq_LIVER_Mouse1.02288762
75PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01525471
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00695080
77* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00132524
78NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99980596
79CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.99739926
80NANOG_18555785_Chip-Seq_ESCs_Mouse0.99686234
81PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99664057
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99588033
83LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97203548
84CTCF_20526341_ChIP-Seq_ESCs_Human0.96290530
85ELF1_20517297_ChIP-Seq_JURKAT_Human0.96262697
86SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93390926
87KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.93331075
88SOX11_22085726_ChIP-Seq_ESNs_Mouse0.93109526
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.92756476
90P53_22387025_ChIP-Seq_ESCs_Mouse0.91052254
91FLI1_21867929_ChIP-Seq_CD8_Mouse0.90781216
92NFYB_21822215_ChIP-Seq_K562_Human0.90773422
93PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.89782974
94TAF15_26573619_Chip-Seq_HEK293_Human0.89639688
95BCOR_27268052_Chip-Seq_Bcells_Human0.87615101
96OCT4_21477851_ChIP-Seq_ESCs_Mouse0.87123817
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86916010
98SOX2_21211035_ChIP-Seq_LN229_Human0.86525089
99CMYC_18555785_Chip-Seq_ESCs_Mouse0.85877136
100EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85229306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.08136818
2MP0001929_abnormal_gametogenesis5.53820067
3MP0008877_abnormal_DNA_methylation3.86112740
4MP0002210_abnormal_sex_determination3.32443691
5MP0002161_abnormal_fertility/fecundity3.31754941
6MP0005670_abnormal_white_adipose3.10131418
7MP0001145_abnormal_male_reproductive2.82667148
8MP0000653_abnormal_sex_gland2.43964893
9MP0002653_abnormal_ependyma_morphology2.06382648
10MP0005410_abnormal_fertilization16.7542084
11MP0002160_abnormal_reproductive_system1.58694560
12MP0003646_muscle_fatigue1.50128271
13MP0004233_abnormal_muscle_weight1.48301688
14MP0005623_abnormal_meninges_morphology1.24880804
15MP0001765_abnormal_ion_homeostasis1.14505962
16MP0002282_abnormal_trachea_morphology1.10834029
17MP0001984_abnormal_olfaction1.03323043
18MP0002234_abnormal_pharynx_morphology0.87919593
19MP0005647_abnormal_sex_gland0.83143335
20MP0005389_reproductive_system_phenotype0.77270270
21MP0008058_abnormal_DNA_repair0.77100545
22MP0003011_delayed_dark_adaptation0.73250289
23MP0003115_abnormal_respiratory_system0.73215110
24MP0008995_early_reproductive_senescence0.72544780
25MP0009046_muscle_twitch0.67655117
26MP0005636_abnormal_mineral_homeostasis0.63707034
27MP0005666_abnormal_adipose_tissue0.62312112
28MP0005377_hearing/vestibular/ear_phenot0.60457362
29MP0003878_abnormal_ear_physiology0.60457362
30MP0001324_abnormal_eye_pigmentation0.52972203
31MP0003329_amyloid_beta_deposits0.51823649
32MP0009278_abnormal_bone_marrow0.49720340
33MP0000358_abnormal_cell_content/0.48882721
34MP0002269_muscular_atrophy0.48623975
35MP0001764_abnormal_homeostasis0.48290396
36MP0001545_abnormal_hematopoietic_system0.46283708
37MP0005397_hematopoietic_system_phenotyp0.46283708
38MP0004036_abnormal_muscle_relaxation0.45336924
39MP0002736_abnormal_nociception_after0.45247133
40MP0000569_abnormal_digit_pigmentation0.45034412
41MP0002928_abnormal_bile_duct0.43617933
42MP0003699_abnormal_female_reproductive0.43248736
43MP0001293_anophthalmia0.42119309
44MP0009115_abnormal_fat_cell0.39802965
45MP0006036_abnormal_mitochondrial_physio0.39797490
46MP0005253_abnormal_eye_physiology0.39256716
47MP0000534_abnormal_ureter_morphology0.38195378
48MP0003950_abnormal_plasma_membrane0.37521648
49MP0010094_abnormal_chromosome_stability0.37101773
50MP0005551_abnormal_eye_electrophysiolog0.36652520
51MP0003879_abnormal_hair_cell0.34627735
52MP0002971_abnormal_brown_adipose0.33809112
53MP0000604_amyloidosis0.30347557
54MP0004019_abnormal_vitamin_homeostasis0.30251819
55MP0003111_abnormal_nucleus_morphology0.29968438
56MP0003942_abnormal_urinary_system0.29646435
57MP0005391_vision/eye_phenotype0.29534596
58MP0004133_heterotaxia0.28868250
59MP0003633_abnormal_nervous_system0.28064186
60MP0002102_abnormal_ear_morphology0.27167161
61MP0001968_abnormal_touch/_nociception0.26799111
62MP0002139_abnormal_hepatobiliary_system0.26535695
63MP0004811_abnormal_neuron_physiology0.26419500
64MP0006035_abnormal_mitochondrial_morpho0.24317873
65MP0002295_abnormal_pulmonary_circulatio0.23951094
66MP0001661_extended_life_span0.23370163
67MP0001119_abnormal_female_reproductive0.23001445
68MP0003948_abnormal_gas_homeostasis0.22959376
69MP0008961_abnormal_basal_metabolism0.22189848
70MP0002169_no_abnormal_phenotype0.21831882
71MP0002873_normal_phenotype0.21558082
72MP0003631_nervous_system_phenotype0.20701936
73MP0001730_embryonic_growth_arrest0.20525203
74MP0003861_abnormal_nervous_system0.20494835
75MP0005375_adipose_tissue_phenotype0.20438045
76MP0004742_abnormal_vestibular_system0.19359675
77MP0002796_impaired_skin_barrier0.19293012
78MP0002152_abnormal_brain_morphology0.19039994
79MP0010307_abnormal_tumor_latency0.18420858
80MP0001849_ear_inflammation0.18207607
81MP0001986_abnormal_taste_sensitivity0.17575961
82MP0002693_abnormal_pancreas_physiology0.16965096
83MP0003959_abnormal_lean_body0.16409901
84MP0003786_premature_aging0.15979856
85MP0003045_fibrosis0.15942250
86MP0002405_respiratory_system_inflammati0.15558225
87MP0001727_abnormal_embryo_implantation0.15362383
88MP0002092_abnormal_eye_morphology0.14705685
89MP0002132_abnormal_respiratory_system0.14477388
90MP0004145_abnormal_muscle_electrophysio0.14466635
91MP0002118_abnormal_lipid_homeostasis0.14124680
92MP0008875_abnormal_xenobiotic_pharmacok0.13967689
93MP0005319_abnormal_enzyme/_coenzyme0.13880385
94MP0004808_abnormal_hematopoietic_stem0.13524882
95MP0000001_mammalian_phenotype0.13435356
96MP0000313_abnormal_cell_death0.12907823
97MP0005423_abnormal_somatic_nervous0.12836437
98MP0005174_abnormal_tail_pigmentation0.12566145
99MP0008569_lethality_at_weaning0.12497434
100MP0002229_neurodegeneration0.12149266

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory epithelium morphology (HP:0012253)9.34974025
2Abnormal respiratory motile cilium morphology (HP:0005938)9.34974025
3Abnormal respiratory motile cilium physiology (HP:0012261)9.27023551
4Rhinitis (HP:0012384)7.47953141
5Chronic bronchitis (HP:0004469)7.41426537
6Abnormal ciliary motility (HP:0012262)7.18707838
7Infertility (HP:0000789)7.02411460
8Nasal polyposis (HP:0100582)6.45957369
9Abnormality of the nasal mucosa (HP:0000433)5.31864736
10Male infertility (HP:0003251)4.85567124
11Bronchitis (HP:0012387)4.61751911
12Bronchiectasis (HP:0002110)4.43894305
13Nephronophthisis (HP:0000090)4.13560950
14Abnormal spermatogenesis (HP:0008669)3.66058613
15Recurrent otitis media (HP:0000403)3.30593419
16Recurrent sinusitis (HP:0011108)3.23504223
17Abnormality of the renal medulla (HP:0100957)3.11120239
18Impulsivity (HP:0100710)2.77028917
19Tubulointerstitial nephritis (HP:0001970)2.76213453
20Recurrent bronchitis (HP:0002837)2.75302160
21Tubular atrophy (HP:0000092)2.61973384
22Cholecystitis (HP:0001082)2.51099573
23Abnormal gallbladder physiology (HP:0012438)2.51099573
24Molar tooth sign on MRI (HP:0002419)2.51049828
25Abnormality of midbrain morphology (HP:0002418)2.51049828
26Tubulointerstitial abnormality (HP:0001969)2.42835618
27Medial flaring of the eyebrow (HP:0010747)2.40278292
28Gonadotropin excess (HP:0000837)2.34755983
29Azoospermia (HP:0000027)2.28339372
30Dyschromatopsia (HP:0007641)2.16129084
31Choroideremia (HP:0001139)2.03683005
32Spastic tetraparesis (HP:0001285)2.02551339
33Tubulointerstitial fibrosis (HP:0005576)2.02178999
34Absent/shortened dynein arms (HP:0200106)13.5466154
35Dynein arm defect of respiratory motile cilia (HP:0012255)13.5466154
36Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0050642
37Decreased central vision (HP:0007663)1.89946722
38Stage 5 chronic kidney disease (HP:0003774)1.78068959
39Abnormal drinking behavior (HP:0030082)1.76407689
40Polydipsia (HP:0001959)1.76407689
41Hemorrhage of the eye (HP:0011885)1.75823521
42Postaxial foot polydactyly (HP:0001830)1.75804878
43Heterotopia (HP:0002282)1.75411500
44Hypoplasia of the capital femoral epiphysis (HP:0003090)1.68420912
45Congenital hepatic fibrosis (HP:0002612)1.65639040
46Neurofibrillary tangles (HP:0002185)1.64394718
47Abnormality of the renal cortex (HP:0011035)1.63020834
48Bile duct proliferation (HP:0001408)1.62781645
49Abnormal biliary tract physiology (HP:0012439)1.62781645
50Abnormality of renal excretion (HP:0011036)1.62709080
51Congenital malformation of the right heart (HP:0011723)1.60705883
52Double outlet right ventricle (HP:0001719)1.60705883
53Asymmetric septal hypertrophy (HP:0001670)1.55391005
54Decreased electroretinogram (ERG) amplitude (HP:0000654)1.54848824
55Bell-shaped thorax (HP:0001591)1.53554424
56Aplasia/Hypoplasia of the lens (HP:0008063)1.53433458
57Short ribs (HP:0000773)1.51648722
58Oculomotor apraxia (HP:0000657)1.50902286
59Abnormality of permanent molar morphology (HP:0011071)1.44928553
60Abnormality of the dental root (HP:0006486)1.44928553
61Taurodontia (HP:0000679)1.44928553
62Renal dysplasia (HP:0000110)1.41733231
63Bundle branch block (HP:0011710)1.41066166
64Easy fatigability (HP:0003388)1.37909879
65Postaxial hand polydactyly (HP:0001162)1.37835703
66Chronic sinusitis (HP:0011109)1.37393359
67Abnormality of dentin (HP:0010299)1.36345771
68Loss of speech (HP:0002371)1.36171433
69Cystic liver disease (HP:0006706)1.35496882
70Abnormality of the dental pulp (HP:0006479)1.34675459
71Abnormality of molar (HP:0011077)1.34379461
72Abnormality of molar morphology (HP:0011070)1.34379461
73Abnormal urine output (HP:0012590)1.34298767
74Fibular hypoplasia (HP:0003038)1.33422722
75Facial cleft (HP:0002006)1.33356716
76Cerebral inclusion bodies (HP:0100314)1.32783833
77Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.31598873
78Absent epiphyses (HP:0010577)1.31598873
79Hemiparesis (HP:0001269)1.29406104
80Congenital primary aphakia (HP:0007707)1.29194266
81Cerebellar dysplasia (HP:0007033)1.28856592
82Gait imbalance (HP:0002141)1.28341859
83Deformed sella turcica (HP:0002681)1.28175853
84Exercise-induced myalgia (HP:0003738)1.27878715
85Abnormality of the lower motor neuron (HP:0002366)1.27664285
86Fatigable weakness (HP:0003473)1.26953655
87Abnormality of the neuromuscular junction (HP:0003398)1.26953655
88Hypercholesterolemia (HP:0003124)1.26089957
89Sensory axonal neuropathy (HP:0003390)1.25041419
90Myoglobinuria (HP:0002913)1.22952596
91Constricted visual fields (HP:0001133)1.22857646
92Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.20486853
93Nephropathy (HP:0000112)1.17770427
94Broad distal phalanx of finger (HP:0009836)1.15357306
95Abnormality of saccadic eye movements (HP:0000570)1.15005289
96Short femoral neck (HP:0100864)1.14869328
97Short thorax (HP:0010306)1.14104108
98Amyotrophic lateral sclerosis (HP:0007354)1.13975156
99Pancreatic fibrosis (HP:0100732)1.12627383
100Retinal dysplasia (HP:0007973)1.12274322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.05601441
2PDK38.05601441
3TESK16.68077532
4PRKD35.47695483
5PDK25.21165802
6ICK4.60933266
7PTK2B2.17971192
8WNK41.99646731
9STK381.91773357
10STK391.85539702
11PNCK1.68837172
12DYRK1B1.66258141
13NEK21.58188475
14PDK11.20324409
15DYRK30.88573958
16MAPK150.86508429
17IRAK10.82676065
18TYRO30.80312593
19RIPK40.76119732
20PDPK10.75739930
21WNK10.75474113
22PASK0.68607032
23TESK20.68381301
24STK30.62477040
25EEF2K0.61721526
26TTK0.61121546
27CCNB10.59864318
28CHEK20.56301648
29PINK10.51945875
30MUSK0.50826808
31CAMK1G0.49701261
32MAP2K60.48612885
33IRAK20.47064283
34STK38L0.45352234
35LMTK20.45019782
36PAK10.39806096
37NTRK20.38171289
38CHEK10.33188220
39MAP3K100.32712253
40PRKCG0.32626825
41PAK20.28451101
42CAMKK10.27502694
43MARK20.26975741
44PAK40.26175312
45MAPKAPK50.24893910
46MTOR0.23856354
47ATM0.23688650
48PLK40.20853248
49ATR0.20795218
50PRKAA10.19091900
51PRKCZ0.17304694
52NEK60.15051651
53PRKCQ0.13331429
54CDK150.11976802
55BRAF0.10894458
56RPS6KB10.10870253
57WEE10.10221095
58BRSK20.10124538
59MARK30.09802151
60CDK180.09303324
61PLK10.08962116
62PRKG20.08265156
63CDK11A0.08151508
64RPS6KA10.08146752
65CSF1R0.07103835
66CDK60.06628639
67TRIB30.06200106
68STK100.05836796
69PKN10.05444593
70CDK140.05423464
71CSNK2A10.05343148
72PIM10.04960007
73GSK3B0.04332826
74BRSK10.03251288
75CDC70.03106454
76PRKACG0.02924439
77PRKCD0.02845784
78STK110.02615686
79PRKG10.02463275
80CDK120.02313191
81CAMK2A0.01843208
82MAP3K50.01264371
83CSNK1D0.01263090
84CLK10.00483506
85EPHB10.00344095
86MAPK80.00329729
87PRKCB0.00109427
88PRKACA-0.0455480
89CSK-0.0413113
90RPS6KA3-0.0388745
91CDK4-0.0297930
92MAP3K1-0.0296134
93AURKA-0.0291179
94YES1-0.0250489
95EGFR-0.0135431
96CSNK2A2-0.0129648
97ZAP70-0.0116534
98CDK1-0.0067384
99CDK2-0.0040502
100PRKCA-0.0013717

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000614.68796254
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.39794628
3Vitamin B6 metabolism_Homo sapiens_hsa007503.61011674
4Pyruvate metabolism_Homo sapiens_hsa006203.32037204
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.24218360
6Linoleic acid metabolism_Homo sapiens_hsa005913.14920374
7Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.72614227
8Propanoate metabolism_Homo sapiens_hsa006402.54105969
9Glucagon signaling pathway_Homo sapiens_hsa049222.53424672
10Carbohydrate digestion and absorption_Homo sapiens_hsa049732.43892632
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.43801069
12Selenocompound metabolism_Homo sapiens_hsa004502.31194196
13Basal transcription factors_Homo sapiens_hsa030222.14466077
14Glycerolipid metabolism_Homo sapiens_hsa005612.01207334
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.96176399
16PPAR signaling pathway_Homo sapiens_hsa033201.92096878
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.87794811
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.77108270
19Fructose and mannose metabolism_Homo sapiens_hsa000511.63007903
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.61814866
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.59368995
22Oocyte meiosis_Homo sapiens_hsa041141.57156479
23Mineral absorption_Homo sapiens_hsa049781.52611705
24Fat digestion and absorption_Homo sapiens_hsa049751.50489439
25Ether lipid metabolism_Homo sapiens_hsa005651.49772545
26Amphetamine addiction_Homo sapiens_hsa050311.48574634
27Dorso-ventral axis formation_Homo sapiens_hsa043201.46520408
28Pentose phosphate pathway_Homo sapiens_hsa000301.46105059
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.46026360
30Fatty acid degradation_Homo sapiens_hsa000711.41584188
31Fatty acid metabolism_Homo sapiens_hsa012121.38922232
32Carbon metabolism_Homo sapiens_hsa012001.27679962
33Cardiac muscle contraction_Homo sapiens_hsa042601.21971648
34Fanconi anemia pathway_Homo sapiens_hsa034601.19180018
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15224090
36Antigen processing and presentation_Homo sapiens_hsa046121.15065554
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.10931233
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.04739833
39Renin secretion_Homo sapiens_hsa049241.04226411
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04068423
41Collecting duct acid secretion_Homo sapiens_hsa049661.00997835
42Glutathione metabolism_Homo sapiens_hsa004801.00164511
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.95861597
44Purine metabolism_Homo sapiens_hsa002300.94589139
45Hedgehog signaling pathway_Homo sapiens_hsa043400.91400623
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.89151525
47Arachidonic acid metabolism_Homo sapiens_hsa005900.89033421
48Huntingtons disease_Homo sapiens_hsa050160.83524373
49mRNA surveillance pathway_Homo sapiens_hsa030150.83333005
50Chemical carcinogenesis_Homo sapiens_hsa052040.80380852
51Insulin secretion_Homo sapiens_hsa049110.79029121
52Bile secretion_Homo sapiens_hsa049760.72411120
53Estrogen signaling pathway_Homo sapiens_hsa049150.72193734
54Biosynthesis of amino acids_Homo sapiens_hsa012300.69657033
55Thyroid hormone synthesis_Homo sapiens_hsa049180.69099005
56Long-term potentiation_Homo sapiens_hsa047200.68980705
57RNA transport_Homo sapiens_hsa030130.68825261
58cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66674670
59Systemic lupus erythematosus_Homo sapiens_hsa053220.66664107
60Legionellosis_Homo sapiens_hsa051340.66108651
61ABC transporters_Homo sapiens_hsa020100.61247341
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.57457583
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54932316
64Pancreatic secretion_Homo sapiens_hsa049720.54338574
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53946326
66Renin-angiotensin system_Homo sapiens_hsa046140.51561482
67Synaptic vesicle cycle_Homo sapiens_hsa047210.49462904
68Calcium signaling pathway_Homo sapiens_hsa040200.48895961
69Salivary secretion_Homo sapiens_hsa049700.48290955
70Protein digestion and absorption_Homo sapiens_hsa049740.47572235
71Endocytosis_Homo sapiens_hsa041440.47368198
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.45760429
73AMPK signaling pathway_Homo sapiens_hsa041520.44000488
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.43976549
75Inositol phosphate metabolism_Homo sapiens_hsa005620.43313685
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41155405
77Gastric acid secretion_Homo sapiens_hsa049710.39232871
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38877358
79VEGF signaling pathway_Homo sapiens_hsa043700.38264908
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37829097
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37287007
82Metabolic pathways_Homo sapiens_hsa011000.35406891
83Sulfur metabolism_Homo sapiens_hsa009200.32444113
84Alcoholism_Homo sapiens_hsa050340.32435717
85Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.31770902
86cAMP signaling pathway_Homo sapiens_hsa040240.31631179
87Taste transduction_Homo sapiens_hsa047420.30940637
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.26839794
89Circadian entrainment_Homo sapiens_hsa047130.26002263
90Pyrimidine metabolism_Homo sapiens_hsa002400.21588791
91Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20150355
92Cocaine addiction_Homo sapiens_hsa050300.19201551
93B cell receptor signaling pathway_Homo sapiens_hsa046620.16162449
94HIF-1 signaling pathway_Homo sapiens_hsa040660.12824523
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09290380
96Salmonella infection_Homo sapiens_hsa051320.09144337
97Basal cell carcinoma_Homo sapiens_hsa052170.08443322
98Wnt signaling pathway_Homo sapiens_hsa043100.06344066
99Viral carcinogenesis_Homo sapiens_hsa052030.05855883
100Retinol metabolism_Homo sapiens_hsa008300.04454636

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