

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 4.12063166 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 4.05015839 |
| 3 | vocalization behavior (GO:0071625) | 4.04499532 |
| 4 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.91797400 |
| 5 | synaptic vesicle maturation (GO:0016188) | 3.86242698 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 3.79790743 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.78991212 |
| 8 | neuron recognition (GO:0008038) | 3.78978460 |
| 9 | layer formation in cerebral cortex (GO:0021819) | 3.77634632 |
| 10 | dendritic spine morphogenesis (GO:0060997) | 3.75184516 |
| 11 | neuron cell-cell adhesion (GO:0007158) | 3.67250821 |
| 12 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.56246890 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.52954712 |
| 14 | axonal fasciculation (GO:0007413) | 3.51640332 |
| 15 | regulation of synapse structural plasticity (GO:0051823) | 3.50991467 |
| 16 | glutamate secretion (GO:0014047) | 3.45369985 |
| 17 | synaptic vesicle exocytosis (GO:0016079) | 3.44441496 |
| 18 | protein localization to synapse (GO:0035418) | 3.42766555 |
| 19 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.41375948 |
| 20 | regulation of synaptic vesicle exocytosis (GO:2000300) | 3.38605866 |
| 21 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.37271733 |
| 22 | positive regulation of synapse maturation (GO:0090129) | 3.36880628 |
| 23 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.35336040 |
| 24 | neuronal action potential propagation (GO:0019227) | 3.28040777 |
| 25 | exploration behavior (GO:0035640) | 3.25378243 |
| 26 | auditory behavior (GO:0031223) | 3.23476815 |
| 27 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.13401589 |
| 28 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.13088209 |
| 29 | dendrite morphogenesis (GO:0048813) | 3.12615205 |
| 30 | glutamate receptor signaling pathway (GO:0007215) | 3.11734844 |
| 31 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.11524514 |
| 32 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.11152472 |
| 33 | axon ensheathment in central nervous system (GO:0032291) | 3.10095440 |
| 34 | central nervous system myelination (GO:0022010) | 3.10095440 |
| 35 | cerebellar granule cell differentiation (GO:0021707) | 3.09367335 |
| 36 | postsynaptic membrane organization (GO:0001941) | 3.07025047 |
| 37 | synaptic transmission, glutamatergic (GO:0035249) | 3.06065090 |
| 38 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.03865930 |
| 39 | axon extension (GO:0048675) | 3.00064483 |
| 40 | establishment of mitochondrion localization (GO:0051654) | 2.96150151 |
| 41 | neuron-neuron synaptic transmission (GO:0007270) | 2.95605138 |
| 42 | potassium ion homeostasis (GO:0055075) | 2.92980874 |
| 43 | activation of protein kinase A activity (GO:0034199) | 2.92958338 |
| 44 | regulation of synaptic vesicle transport (GO:1902803) | 2.92658532 |
| 45 | transmission of nerve impulse (GO:0019226) | 2.90094163 |
| 46 | negative regulation of catenin import into nucleus (GO:0035414) | 2.89184072 |
| 47 | dendritic spine organization (GO:0097061) | 2.84587979 |
| 48 | cellular sodium ion homeostasis (GO:0006883) | 2.82120717 |
| 49 | neuromuscular process controlling balance (GO:0050885) | 2.81692401 |
| 50 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.81629814 |
| 51 | neuronal ion channel clustering (GO:0045161) | 2.80975231 |
| 52 | neurotransmitter secretion (GO:0007269) | 2.79402428 |
| 53 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.79096044 |
| 54 | response to auditory stimulus (GO:0010996) | 2.78934335 |
| 55 | long-term memory (GO:0007616) | 2.78895120 |
| 56 | presynaptic membrane assembly (GO:0097105) | 2.74645152 |
| 57 | amino acid import (GO:0043090) | 2.74465991 |
| 58 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.74410967 |
| 59 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.73987773 |
| 60 | neuron remodeling (GO:0016322) | 2.73257106 |
| 61 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.73057921 |
| 62 | cerebral cortex radially oriented cell migration (GO:0021799) | 2.72685559 |
| 63 | paraxial mesoderm development (GO:0048339) | 2.72423598 |
| 64 | presynaptic membrane organization (GO:0097090) | 2.70999921 |
| 65 | regulation of synapse maturation (GO:0090128) | 2.70908887 |
| 66 | neuron projection extension (GO:1990138) | 2.69297814 |
| 67 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.68680371 |
| 68 | regulation of dendritic spine development (GO:0060998) | 2.68296144 |
| 69 | synaptic vesicle endocytosis (GO:0048488) | 2.67283172 |
| 70 | prepulse inhibition (GO:0060134) | 2.66536309 |
| 71 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.66044720 |
| 72 | cell communication by electrical coupling (GO:0010644) | 2.65713818 |
| 73 | regulation of synaptic plasticity (GO:0048167) | 2.64575455 |
| 74 | peptidyl-tyrosine autophosphorylation (GO:0038083) | 2.62950788 |
| 75 | regulation of postsynaptic membrane potential (GO:0060078) | 2.62920704 |
| 76 | synapse assembly (GO:0007416) | 2.62482704 |
| 77 | establishment of nucleus localization (GO:0040023) | 2.62097593 |
| 78 | mechanosensory behavior (GO:0007638) | 2.61014214 |
| 79 | positive regulation of membrane potential (GO:0045838) | 2.60080024 |
| 80 | innervation (GO:0060384) | 2.60034024 |
| 81 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.58171582 |
| 82 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.57805236 |
| 83 | gamma-aminobutyric acid transport (GO:0015812) | 2.56597251 |
| 84 | L-amino acid import (GO:0043092) | 2.56149283 |
| 85 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.56100265 |
| 86 | cellular potassium ion homeostasis (GO:0030007) | 2.55368219 |
| 87 | positive regulation of dendritic spine development (GO:0060999) | 2.54520649 |
| 88 | synapse organization (GO:0050808) | 2.53847919 |
| 89 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.53710684 |
| 90 | mitochondrion transport along microtubule (GO:0047497) | 2.53091154 |
| 91 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 2.53091154 |
| 92 | long-term synaptic potentiation (GO:0060291) | 2.52009474 |
| 93 | cerebellar Purkinje cell layer development (GO:0021680) | 2.51688371 |
| 94 | membrane assembly (GO:0071709) | 2.51037129 |
| 95 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 2.49664290 |
| 96 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 2.49513333 |
| 97 | potassium ion import (GO:0010107) | 2.49111701 |
| 98 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.48785786 |
| 99 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.48142260 |
| 100 | ephrin receptor signaling pathway (GO:0048013) | 2.44503543 |
| 101 | cell migration in hindbrain (GO:0021535) | 2.43130864 |
| 102 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 2.42231637 |
| 103 | axon extension involved in axon guidance (GO:0048846) | 2.42231637 |
| 104 | learning (GO:0007612) | 2.41884692 |
| 105 | mating behavior (GO:0007617) | 2.41528117 |
| 106 | membrane hyperpolarization (GO:0060081) | 2.41441777 |
| 107 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.41313828 |
| 108 | glycine transport (GO:0015816) | 2.40477432 |
| 109 | protein retention in ER lumen (GO:0006621) | 2.40470739 |
| 110 | nerve growth factor signaling pathway (GO:0038180) | 2.40342239 |
| 111 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.40203064 |
| 112 | regulation of vesicle fusion (GO:0031338) | 2.39846601 |
| 113 | negative regulation of protein localization to cell surface (GO:2000009) | 2.38947842 |
| 114 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.38431924 |
| 115 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.38176683 |
| 116 | sodium ion export (GO:0071436) | 2.38124838 |
| 117 | vesicle transport along microtubule (GO:0047496) | 2.38099934 |
| 118 | positive regulation of synapse assembly (GO:0051965) | 2.37827746 |
| 119 | negative regulation of axon extension (GO:0030517) | 2.37179048 |
| 120 | myelination in peripheral nervous system (GO:0022011) | 2.37159921 |
| 121 | peripheral nervous system axon ensheathment (GO:0032292) | 2.37159921 |
| 122 | regulation of axon guidance (GO:1902667) | 2.36996838 |
| 123 | proline transport (GO:0015824) | 2.36647934 |
| 124 | neurotransmitter transport (GO:0006836) | 2.36643918 |
| 125 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 2.36533604 |
| 126 | regulation of neurotransmitter secretion (GO:0046928) | 2.34150034 |
| 127 | cAMP biosynthetic process (GO:0006171) | 2.34110935 |
| 128 | neuromuscular process (GO:0050905) | 2.33864158 |
| 129 | developmental cell growth (GO:0048588) | 2.33760994 |
| 130 | nucleobase catabolic process (GO:0046113) | 2.33241769 |
| 131 | organelle transport along microtubule (GO:0072384) | 2.33088376 |
| 132 | negative regulation of axonogenesis (GO:0050771) | 2.32301005 |
| 133 | positive regulation of dendrite development (GO:1900006) | 2.30986346 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.70626840 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.29852324 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.09610944 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.05253288 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.01460324 |
| 6 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.84117659 |
| 7 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.84117659 |
| 8 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.76418215 |
| 9 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.72441515 |
| 10 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.71018028 |
| 11 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.68714188 |
| 12 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.65961525 |
| 13 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.65595476 |
| 14 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.50473663 |
| 15 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.35323780 |
| 16 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.26067558 |
| 17 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.22694360 |
| 18 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.21220744 |
| 19 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.20174128 |
| 20 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.06242885 |
| 21 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.95023942 |
| 22 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.90829704 |
| 23 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.87911058 |
| 24 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.87345036 |
| 25 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.86970178 |
| 26 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77436069 |
| 27 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.70150062 |
| 28 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.67194211 |
| 29 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.65287126 |
| 30 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.65057798 |
| 31 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.62637481 |
| 32 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.62076302 |
| 33 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.61116685 |
| 34 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.57655142 |
| 35 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.55754415 |
| 36 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.55727235 |
| 37 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.53205770 |
| 38 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.50437609 |
| 39 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.47305550 |
| 40 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.44791525 |
| 41 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.44543148 |
| 42 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.42550621 |
| 43 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.42383497 |
| 44 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.41925128 |
| 45 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.41920729 |
| 46 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.41187494 |
| 47 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.40592697 |
| 48 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.39815277 |
| 49 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.39213753 |
| 50 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.38459357 |
| 51 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.38355185 |
| 52 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.37882575 |
| 53 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.37559835 |
| 54 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.36358691 |
| 55 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.36066640 |
| 56 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.35522454 |
| 57 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.35321630 |
| 58 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.35115742 |
| 59 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.35068937 |
| 60 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.34339789 |
| 61 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.34106611 |
| 62 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.34043136 |
| 63 | * P300_19829295_ChIP-Seq_ESCs_Human | 1.33717236 |
| 64 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.32488550 |
| 65 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.32470983 |
| 66 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.32274573 |
| 67 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.31671624 |
| 68 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.28077810 |
| 69 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.27914380 |
| 70 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.25645627 |
| 71 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.21973323 |
| 72 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.19807014 |
| 73 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.19438504 |
| 74 | * CTCF_27219007_Chip-Seq_Bcells_Human | 1.19349985 |
| 75 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.17807948 |
| 76 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.17122329 |
| 77 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16043295 |
| 78 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.15995920 |
| 79 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.14310394 |
| 80 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.13569267 |
| 81 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.12248930 |
| 82 | * AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.09190696 |
| 83 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.08870974 |
| 84 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.08391532 |
| 85 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.08088011 |
| 86 | STAT3_23295773_ChIP-Seq_U87_Human | 1.07915386 |
| 87 | AR_19668381_ChIP-Seq_PC3_Human | 1.07671493 |
| 88 | AR_25329375_ChIP-Seq_VCAP_Human | 1.07096208 |
| 89 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.07060707 |
| 90 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.05077955 |
| 91 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.04775760 |
| 92 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.04353182 |
| 93 | TP53_16413492_ChIP-PET_HCT116_Human | 1.03630253 |
| 94 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.03527493 |
| 95 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.03318166 |
| 96 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.02819520 |
| 97 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.02328552 |
| 98 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.01949448 |
| 99 | * SMAD4_21741376_ChIP-Seq_HESCs_Human | 1.00414164 |
| 100 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.99311143 |
| 101 | IGF1R_20145208_ChIP-Seq_DFB_Human | 0.98586232 |
| 102 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98294194 |
| 103 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.97929474 |
| 104 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.97769203 |
| 105 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 0.96035355 |
| 106 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.95880981 |
| 107 | SOX9_26525672_Chip-Seq_HEART_Mouse | 0.95312333 |
| 108 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.94506648 |
| 109 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.94401491 |
| 110 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 0.94350800 |
| 111 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.94210390 |
| 112 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.94126612 |
| 113 | * ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.93215747 |
| 114 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.91828751 |
| 115 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.91762512 |
| 116 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.91762512 |
| 117 | TCF4_23295773_ChIP-Seq_U87_Human | 0.91513775 |
| 118 | * KDM2B_26808549_Chip-Seq_K562_Human | 0.90825377 |
| 119 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 0.90658962 |
| 120 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.90342460 |
| 121 | FUS_26573619_Chip-Seq_HEK293_Human | 0.90278651 |
| 122 | * UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.89567112 |
| 123 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.89435541 |
| 124 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 0.89401598 |
| 125 | * KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 0.88979195 |
| 126 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.85988922 |
| 127 | NANOG_18347094_ChIP-ChIP_MESCs_Mouse | 0.81699884 |
| 128 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.81375458 |
| 129 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.81335929 |
| 130 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 0.80932578 |
| 131 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.79800100 |
| 132 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 0.79247106 |
| 133 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.79177879 |
| 134 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.78790667 |
| 135 | NFIB_24661679_ChIP-Seq_LUNG_Mouse | 0.78269305 |
| 136 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 0.77996838 |
| 137 | TCF3_18347094_ChIP-ChIP_MESCs_Mouse | 0.77376665 |
| 138 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.75716447 |
| 139 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.75563590 |
| 140 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.74923435 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 4.90046712 |
| 2 | MP0003880_abnormal_central_pattern | 3.95619037 |
| 3 | MP0004270_analgesia | 3.28850800 |
| 4 | MP0003635_abnormal_synaptic_transmissio | 3.19356296 |
| 5 | MP0002063_abnormal_learning/memory/cond | 2.58349328 |
| 6 | MP0009745_abnormal_behavioral_response | 2.56417986 |
| 7 | MP0000566_synostosis | 2.42598877 |
| 8 | MP0009780_abnormal_chondrocyte_physiolo | 2.28484154 |
| 9 | MP0002064_seizures | 2.27126764 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.24463250 |
| 11 | MP0003122_maternal_imprinting | 2.21318272 |
| 12 | MP0001486_abnormal_startle_reflex | 2.19714112 |
| 13 | MP0002572_abnormal_emotion/affect_behav | 2.15664705 |
| 14 | MP0000778_abnormal_nervous_system | 2.12842233 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.06311562 |
| 16 | MP0002272_abnormal_nervous_system | 2.03432331 |
| 17 | MP0005623_abnormal_meninges_morphology | 1.99747343 |
| 18 | MP0005423_abnormal_somatic_nervous | 1.98293635 |
| 19 | MP0002822_catalepsy | 1.96410487 |
| 20 | MP0003123_paternal_imprinting | 1.89835048 |
| 21 | MP0002736_abnormal_nociception_after | 1.81624054 |
| 22 | MP0009046_muscle_twitch | 1.81508247 |
| 23 | MP0004272_abnormal_basement_membrane | 1.76045611 |
| 24 | MP0004858_abnormal_nervous_system | 1.71987417 |
| 25 | MP0001440_abnormal_grooming_behavior | 1.66086751 |
| 26 | MP0002735_abnormal_chemical_nociception | 1.61582888 |
| 27 | MP0002733_abnormal_thermal_nociception | 1.60640802 |
| 28 | MP0001529_abnormal_vocalization | 1.57910759 |
| 29 | MP0001970_abnormal_pain_threshold | 1.53326706 |
| 30 | MP0004885_abnormal_endolymph | 1.51862128 |
| 31 | MP0002184_abnormal_innervation | 1.49863280 |
| 32 | MP0003283_abnormal_digestive_organ | 1.49148972 |
| 33 | MP0002067_abnormal_sensory_capabilities | 1.47309514 |
| 34 | MP0000955_abnormal_spinal_cord | 1.45182292 |
| 35 | MP0003329_amyloid_beta_deposits | 1.44341369 |
| 36 | MP0002557_abnormal_social/conspecific_i | 1.44089402 |
| 37 | MP0001501_abnormal_sleep_pattern | 1.44055686 |
| 38 | MP0000013_abnormal_adipose_tissue | 1.43830608 |
| 39 | MP0010368_abnormal_lymphatic_system | 1.42767557 |
| 40 | MP0000751_myopathy | 1.40069380 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.39424706 |
| 42 | MP0004811_abnormal_neuron_physiology | 1.37377108 |
| 43 | MP0005409_darkened_coat_color | 1.31762779 |
| 44 | MP0006276_abnormal_autonomic_nervous | 1.29810264 |
| 45 | MP0000049_abnormal_middle_ear | 1.29189496 |
| 46 | MP0008569_lethality_at_weaning | 1.28099245 |
| 47 | MP0003119_abnormal_digestive_system | 1.27423286 |
| 48 | MP0005646_abnormal_pituitary_gland | 1.27236503 |
| 49 | MP0005386_behavior/neurological_phenoty | 1.27031629 |
| 50 | MP0004924_abnormal_behavior | 1.27031629 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.26496576 |
| 52 | MP0001188_hyperpigmentation | 1.23135230 |
| 53 | MP0000920_abnormal_myelination | 1.22850829 |
| 54 | MP0009379_abnormal_foot_pigmentation | 1.21323900 |
| 55 | MP0004145_abnormal_muscle_electrophysio | 1.20710381 |
| 56 | MP0006292_abnormal_olfactory_placode | 1.20196702 |
| 57 | MP0005167_abnormal_blood-brain_barrier | 1.18986517 |
| 58 | MP0005257_abnormal_intraocular_pressure | 1.17654911 |
| 59 | MP0004085_abnormal_heartbeat | 1.17481875 |
| 60 | MP0001879_abnormal_lymphatic_vessel | 1.15462274 |
| 61 | MP0001346_abnormal_lacrimal_gland | 1.15420791 |
| 62 | MP0002066_abnormal_motor_capabilities/c | 1.15057690 |
| 63 | MP0003705_abnormal_hypodermis_morpholog | 1.14205624 |
| 64 | MP0003633_abnormal_nervous_system | 1.07823142 |
| 65 | MP0005394_taste/olfaction_phenotype | 1.07783437 |
| 66 | MP0005499_abnormal_olfactory_system | 1.07783437 |
| 67 | MP0003938_abnormal_ear_development | 1.07168092 |
| 68 | MP0002233_abnormal_nose_morphology | 1.06926010 |
| 69 | MP0001299_abnormal_eye_distance/ | 1.05612152 |
| 70 | MP0001177_atelectasis | 1.05547901 |
| 71 | MP0003385_abnormal_body_wall | 1.05387536 |
| 72 | MP0001293_anophthalmia | 1.05219244 |
| 73 | MP0010386_abnormal_urinary_bladder | 1.04921742 |
| 74 | MP0003634_abnormal_glial_cell | 1.04212850 |
| 75 | MP0002152_abnormal_brain_morphology | 1.03924859 |
| 76 | MP0003890_abnormal_embryonic-extraembry | 1.03861195 |
| 77 | MP0002249_abnormal_larynx_morphology | 1.02377772 |
| 78 | MP0001905_abnormal_dopamine_level | 1.00804581 |
| 79 | MP0000537_abnormal_urethra_morphology | 1.00367100 |
| 80 | MP0000534_abnormal_ureter_morphology | 0.99430346 |
| 81 | MP0005171_absent_coat_pigmentation | 0.99388035 |
| 82 | MP0001502_abnormal_circadian_rhythm | 0.99208475 |
| 83 | MP0003631_nervous_system_phenotype | 0.99030746 |
| 84 | MP0008438_abnormal_cutaneous_collagen | 0.94863929 |
| 85 | MP0002697_abnormal_eye_size | 0.94422743 |
| 86 | MP0004133_heterotaxia | 0.93832171 |
| 87 | MP0002653_abnormal_ependyma_morphology | 0.93110004 |
| 88 | MP0003937_abnormal_limbs/digits/tail_de | 0.92905402 |
| 89 | MP0004742_abnormal_vestibular_system | 0.91995110 |
| 90 | MP0005645_abnormal_hypothalamus_physiol | 0.91310768 |
| 91 | MP0002638_abnormal_pupillary_reflex | 0.90418198 |
| 92 | MP0004215_abnormal_myocardial_fiber | 0.90047644 |
| 93 | MP0003137_abnormal_impulse_conducting | 0.89496310 |
| 94 | MP0000428_abnormal_craniofacial_morphol | 0.89117534 |
| 95 | MP0000026_abnormal_inner_ear | 0.88701082 |
| 96 | MP0000762_abnormal_tongue_morphology | 0.88331002 |
| 97 | MP0000462_abnormal_digestive_system | 0.87217434 |
| 98 | MP0002081_perinatal_lethality | 0.87067902 |
| 99 | MP0004484_altered_response_of | 0.86953277 |
| 100 | MP0009053_abnormal_anal_canal | 0.86914400 |
| 101 | MP0003787_abnormal_imprinting | 0.86830760 |
| 102 | MP0002116_abnormal_craniofacial_bone | 0.85041950 |
| 103 | MP0005503_abnormal_tendon_morphology | 0.84621535 |
| 104 | MP0003632_abnormal_nervous_system | 0.83983971 |
| 105 | MP0002089_abnormal_postnatal_growth/wei | 0.83923014 |
| 106 | MP0002837_dystrophic_cardiac_calcinosis | 0.83773212 |
| 107 | MP0003690_abnormal_glial_cell | 0.81336021 |
| 108 | MP0003755_abnormal_palate_morphology | 0.80989776 |
| 109 | MP0002234_abnormal_pharynx_morphology | 0.80876408 |
| 110 | MP0002102_abnormal_ear_morphology | 0.78473405 |
| 111 | MP0001286_abnormal_eye_development | 0.78334092 |
| 112 | MP0003935_abnormal_craniofacial_develop | 0.78302614 |
| 113 | MP0005187_abnormal_penis_morphology | 0.78183068 |
| 114 | MP0001485_abnormal_pinna_reflex | 0.78142647 |
| 115 | MP0009250_abnormal_appendicular_skeleto | 0.77947400 |
| 116 | MP0001963_abnormal_hearing_physiology | 0.77439503 |
| 117 | MP0003942_abnormal_urinary_system | 0.77131142 |
| 118 | MP0004084_abnormal_cardiac_muscle | 0.76940790 |
| 119 | MP0003879_abnormal_hair_cell | 0.76474506 |
| 120 | MP0001664_abnormal_digestion | 0.76466855 |
| 121 | MP0004036_abnormal_muscle_relaxation | 0.75463977 |
| 122 | MP0006138_congestive_heart_failure | 0.75310773 |
| 123 | MP0005620_abnormal_muscle_contractility | 0.75189862 |
| 124 | MP0002752_abnormal_somatic_nervous | 0.74960211 |
| 125 | MP0005595_abnormal_vascular_smooth | 0.74823038 |
| 126 | MP0000631_abnormal_neuroendocrine_gland | 0.74788279 |
| 127 | MP0003121_genomic_imprinting | 0.74352672 |
| 128 | MP0001984_abnormal_olfaction | 0.74179879 |
| 129 | MP0004043_abnormal_pH_regulation | 0.73766720 |
| 130 | MP0003861_abnormal_nervous_system | 0.72772455 |
| 131 | MP0010030_abnormal_orbit_morphology | 0.71291368 |
| 132 | MP0002069_abnormal_eating/drinking_beha | 0.70715766 |
| 133 | MP0002972_abnormal_cardiac_muscle | 0.70111136 |
| 134 | MP0004142_abnormal_muscle_tone | 0.69660884 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.03589635 |
| 2 | Focal motor seizures (HP:0011153) | 4.94091487 |
| 3 | Focal seizures (HP:0007359) | 3.74102277 |
| 4 | Termporal pattern (HP:0011008) | 3.31450817 |
| 5 | Insidious onset (HP:0003587) | 3.31450817 |
| 6 | Epileptic encephalopathy (HP:0200134) | 3.28603936 |
| 7 | Neurofibrillary tangles (HP:0002185) | 3.17913636 |
| 8 | Ankle clonus (HP:0011448) | 3.10815311 |
| 9 | Action tremor (HP:0002345) | 3.02909622 |
| 10 | Neonatal short-limb short stature (HP:0008921) | 3.01937556 |
| 11 | Megalencephaly (HP:0001355) | 3.01219874 |
| 12 | Cerebral inclusion bodies (HP:0100314) | 2.90229878 |
| 13 | Aplasia of the phalanges of the hand (HP:0009802) | 2.79563664 |
| 14 | Aplasia involving bones of the extremities (HP:0009825) | 2.79563664 |
| 15 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.79563664 |
| 16 | Coronal craniosynostosis (HP:0004440) | 2.79154172 |
| 17 | Visual hallucinations (HP:0002367) | 2.78796216 |
| 18 | Supranuclear gaze palsy (HP:0000605) | 2.76438373 |
| 19 | Atonic seizures (HP:0010819) | 2.73357683 |
| 20 | Turricephaly (HP:0000262) | 2.66004311 |
| 21 | Abnormality of the lower motor neuron (HP:0002366) | 2.64963622 |
| 22 | Buphthalmos (HP:0000557) | 2.62954740 |
| 23 | Protrusio acetabuli (HP:0003179) | 2.59900547 |
| 24 | Broad-based gait (HP:0002136) | 2.55035006 |
| 25 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.51557414 |
| 26 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.51557414 |
| 27 | Hemiparesis (HP:0001269) | 2.41152949 |
| 28 | Generalized tonic-clonic seizures (HP:0002069) | 2.40911121 |
| 29 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.39786120 |
| 30 | Anxiety (HP:0000739) | 2.38267625 |
| 31 | Abnormality of the corticospinal tract (HP:0002492) | 2.37084041 |
| 32 | Hyperventilation (HP:0002883) | 2.33210310 |
| 33 | Poor eye contact (HP:0000817) | 2.32089055 |
| 34 | Progressive cerebellar ataxia (HP:0002073) | 2.31977752 |
| 35 | Depression (HP:0000716) | 2.31531223 |
| 36 | Lower limb muscle weakness (HP:0007340) | 2.28006814 |
| 37 | Absence seizures (HP:0002121) | 2.26087448 |
| 38 | Febrile seizures (HP:0002373) | 2.25699254 |
| 39 | Partial duplication of thumb phalanx (HP:0009944) | 2.25154167 |
| 40 | Premature rupture of membranes (HP:0001788) | 2.24528894 |
| 41 | Limb dystonia (HP:0002451) | 2.22101098 |
| 42 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.18680310 |
| 43 | Amblyopia (HP:0000646) | 2.17834972 |
| 44 | Abnormal eating behavior (HP:0100738) | 2.17721694 |
| 45 | Dysmetria (HP:0001310) | 2.16644716 |
| 46 | Bronchomalacia (HP:0002780) | 2.16587601 |
| 47 | Urinary urgency (HP:0000012) | 2.16148926 |
| 48 | Scanning speech (HP:0002168) | 2.14406591 |
| 49 | Agitation (HP:0000713) | 2.14004302 |
| 50 | Lower limb amyotrophy (HP:0007210) | 2.11552495 |
| 51 | Spastic gait (HP:0002064) | 2.10522543 |
| 52 | Torticollis (HP:0000473) | 2.10415008 |
| 53 | Elevated circulating parathyroid hormone (PTH) level (HP:0003165) | 2.09009940 |
| 54 | Dialeptic seizures (HP:0011146) | 2.08591642 |
| 55 | Partial duplication of the phalanx of hand (HP:0009999) | 2.07410563 |
| 56 | Papilledema (HP:0001085) | 2.04175020 |
| 57 | Sleep apnea (HP:0010535) | 2.03373710 |
| 58 | Septo-optic dysplasia (HP:0100842) | 2.02813340 |
| 59 | Hepatoblastoma (HP:0002884) | 2.02349780 |
| 60 | Drooling (HP:0002307) | 2.00063954 |
| 61 | Excessive salivation (HP:0003781) | 2.00063954 |
| 62 | Cortical dysplasia (HP:0002539) | 1.98437941 |
| 63 | Truncal ataxia (HP:0002078) | 1.98428048 |
| 64 | Abnormal social behavior (HP:0012433) | 1.98149446 |
| 65 | Impaired social interactions (HP:0000735) | 1.98149446 |
| 66 | Dysdiadochokinesis (HP:0002075) | 1.97280178 |
| 67 | Retinal dysplasia (HP:0007973) | 1.96968138 |
| 68 | Vitreoretinal degeneration (HP:0000655) | 1.96533480 |
| 69 | Broad metatarsal (HP:0001783) | 1.92295678 |
| 70 | Shallow orbits (HP:0000586) | 1.89552519 |
| 71 | Overgrowth (HP:0001548) | 1.89401287 |
| 72 | Hemiplegia (HP:0002301) | 1.88879823 |
| 73 | Trigonocephaly (HP:0000243) | 1.88795407 |
| 74 | Renal duplication (HP:0000075) | 1.88766543 |
| 75 | Type II lissencephaly (HP:0007260) | 1.88316264 |
| 76 | Overriding aorta (HP:0002623) | 1.87229850 |
| 77 | Pheochromocytoma (HP:0002666) | 1.86805619 |
| 78 | Cutaneous finger syndactyly (HP:0010554) | 1.83907721 |
| 79 | Intention tremor (HP:0002080) | 1.83558981 |
| 80 | Hypoventilation (HP:0002791) | 1.83136057 |
| 81 | Hydroureter (HP:0000072) | 1.82825855 |
| 82 | Arnold-Chiari malformation (HP:0002308) | 1.82731529 |
| 83 | Prolonged QT interval (HP:0001657) | 1.81550503 |
| 84 | Increased circulating renin level (HP:0000848) | 1.80065992 |
| 85 | Abnormality of dentin (HP:0010299) | 1.79271016 |
| 86 | Onion bulb formation (HP:0003383) | 1.79157952 |
| 87 | Wide anterior fontanel (HP:0000260) | 1.78767063 |
| 88 | Pointed chin (HP:0000307) | 1.78607589 |
| 89 | Annular pancreas (HP:0001734) | 1.78367535 |
| 90 | Insomnia (HP:0100785) | 1.77909755 |
| 91 | Focal dystonia (HP:0004373) | 1.77371451 |
| 92 | Progressive inability to walk (HP:0002505) | 1.76272533 |
| 93 | Congenital glaucoma (HP:0001087) | 1.74688751 |
| 94 | Increased variability in muscle fiber diameter (HP:0003557) | 1.74283639 |
| 95 | Short 4th metacarpal (HP:0010044) | 1.72639656 |
| 96 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.72639656 |
| 97 | Ankyloglossia (HP:0010296) | 1.72529805 |
| 98 | Stereotypic behavior (HP:0000733) | 1.72077519 |
| 99 | Hammertoe (HP:0001765) | 1.71559299 |
| 100 | Vascular tortuosity (HP:0004948) | 1.71473359 |
| 101 | Arterial tortuosity (HP:0005116) | 1.69341436 |
| 102 | Mutism (HP:0002300) | 1.69274669 |
| 103 | Hyperacusis (HP:0010780) | 1.68024258 |
| 104 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.68009444 |
| 105 | Hypoplasia of the brainstem (HP:0002365) | 1.68009444 |
| 106 | Genetic anticipation (HP:0003743) | 1.67803207 |
| 107 | Exotropia (HP:0000577) | 1.67708426 |
| 108 | Epileptiform EEG discharges (HP:0011182) | 1.66741397 |
| 109 | Postural instability (HP:0002172) | 1.64885934 |
| 110 | Abnormality of the 4th metacarpal (HP:0010012) | 1.63826412 |
| 111 | Absent speech (HP:0001344) | 1.63791728 |
| 112 | Ulnar bowing (HP:0003031) | 1.63191035 |
| 113 | Bladder diverticulum (HP:0000015) | 1.62737654 |
| 114 | Diplopia (HP:0000651) | 1.62041431 |
| 115 | Abnormality of binocular vision (HP:0011514) | 1.62041431 |
| 116 | Omphalocele (HP:0001539) | 1.61644591 |
| 117 | Obstructive sleep apnea (HP:0002870) | 1.61478992 |
| 118 | Bundle branch block (HP:0011710) | 1.60875863 |
| 119 | High anterior hairline (HP:0009890) | 1.60874361 |
| 120 | EEG with generalized epileptiform discharges (HP:0011198) | 1.60710178 |
| 121 | Craniofacial dystonia (HP:0012179) | 1.60357845 |
| 122 | Abnormality of the middle phalanges of the toes (HP:0010183) | 1.60119583 |
| 123 | Incomplete penetrance (HP:0003829) | 1.59508162 |
| 124 | Polyphagia (HP:0002591) | 1.59099116 |
| 125 | Cutaneous syndactyly (HP:0012725) | 1.58627940 |
| 126 | Abnormal EKG (HP:0003115) | 1.57648527 |
| 127 | Narrow nasal bridge (HP:0000446) | 1.57007223 |
| 128 | Thickened helices (HP:0000391) | 1.56931982 |
| 129 | Lower limb asymmetry (HP:0100559) | 1.56403125 |
| 130 | Choanal stenosis (HP:0000452) | 1.55689464 |
| 131 | Generalized hypotonia (HP:0001290) | 1.55249326 |
| 132 | Alacrima (HP:0000522) | 1.54588145 |
| 133 | Elfin facies (HP:0004428) | 1.54428856 |
| 134 | Split foot (HP:0001839) | 1.53949295 |
| 135 | Vertebral arch anomaly (HP:0008438) | 1.53942178 |
| 136 | Bowel diverticulosis (HP:0005222) | 1.48042126 |
| 137 | Mild short stature (HP:0003502) | 1.47624854 |
| 138 | Mitral regurgitation (HP:0001653) | 1.47005941 |
| 139 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 1.46152663 |
| 140 | Atrophic scars (HP:0001075) | 1.45987351 |
| 141 | Hyperextensible skin (HP:0000974) | 1.45622459 |
| 142 | Hand muscle atrophy (HP:0009130) | 1.45190135 |
| 143 | Mixed hearing impairment (HP:0000410) | 1.44603785 |
| 144 | Preaxial foot polydactyly (HP:0001841) | 1.43566429 |
| 145 | Abnormality of the aortic arch (HP:0012303) | 1.42754636 |
| 146 | Upper limb amyotrophy (HP:0009129) | 1.41560740 |
| 147 | Distal upper limb amyotrophy (HP:0007149) | 1.41560740 |
| 148 | Renovascular hypertension (HP:0100817) | 1.41387503 |
| 149 | Thin ribs (HP:0000883) | 1.40894546 |
| 150 | Abnormality of the diencephalon (HP:0010662) | 1.40645232 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 4.45459295 |
| 2 | NTRK3 | 3.54902262 |
| 3 | MARK1 | 3.01029819 |
| 4 | MAP3K9 | 2.37685258 |
| 5 | MINK1 | 2.31888311 |
| 6 | PRKD3 | 2.26158858 |
| 7 | NTRK1 | 2.18496213 |
| 8 | TIE1 | 1.98131509 |
| 9 | DAPK2 | 1.93221009 |
| 10 | PAK6 | 1.88291803 |
| 11 | MAP3K4 | 1.87333465 |
| 12 | NTRK2 | 1.74546471 |
| 13 | CASK | 1.69989125 |
| 14 | TNIK | 1.66769102 |
| 15 | UHMK1 | 1.62642490 |
| 16 | KSR2 | 1.57882264 |
| 17 | MAPK13 | 1.55150014 |
| 18 | KSR1 | 1.45900143 |
| 19 | BCR | 1.44879376 |
| 20 | CDK5 | 1.44803848 |
| 21 | STK39 | 1.44716387 |
| 22 | OXSR1 | 1.40503156 |
| 23 | PTK2B | 1.37352361 |
| 24 | MAP2K7 | 1.35678934 |
| 25 | ICK | 1.34910063 |
| 26 | LATS2 | 1.32882418 |
| 27 | EPHB2 | 1.31565169 |
| 28 | CAMKK1 | 1.31103672 |
| 29 | PLK2 | 1.26683424 |
| 30 | PHKG2 | 1.26508568 |
| 31 | PHKG1 | 1.26508568 |
| 32 | SIK2 | 1.23128641 |
| 33 | MAP3K12 | 1.22737604 |
| 34 | PAK3 | 1.22457759 |
| 35 | DMPK | 1.19470646 |
| 36 | DYRK2 | 1.17577824 |
| 37 | FER | 1.14282697 |
| 38 | WNK4 | 1.10681500 |
| 39 | MAP2K4 | 1.09765724 |
| 40 | CAMK2A | 1.06035424 |
| 41 | PNCK | 1.04414135 |
| 42 | LMTK2 | 1.03944976 |
| 43 | DDR2 | 1.02858752 |
| 44 | CAMK2B | 1.01396440 |
| 45 | PDGFRA | 1.00705181 |
| 46 | TYRO3 | 0.97960897 |
| 47 | PRPF4B | 0.97721322 |
| 48 | CDK14 | 0.97200660 |
| 49 | FGFR2 | 0.95761707 |
| 50 | MAP3K2 | 0.94378137 |
| 51 | GRK5 | 0.94077982 |
| 52 | MAPKAPK5 | 0.93284045 |
| 53 | SGK494 | 0.92277769 |
| 54 | SGK223 | 0.92277769 |
| 55 | CDK18 | 0.90968879 |
| 56 | ROCK2 | 0.90827087 |
| 57 | CDK15 | 0.88585437 |
| 58 | PRKCE | 0.84348984 |
| 59 | PRKCG | 0.82987173 |
| 60 | RET | 0.81555220 |
| 61 | PRKCH | 0.80999884 |
| 62 | CDK19 | 0.80740256 |
| 63 | PKN1 | 0.78641852 |
| 64 | WNK1 | 0.77157840 |
| 65 | CDK11A | 0.76902844 |
| 66 | ARAF | 0.76302227 |
| 67 | MARK2 | 0.75271431 |
| 68 | MAP3K10 | 0.74925657 |
| 69 | CAMK1 | 0.71943674 |
| 70 | SGK2 | 0.71925952 |
| 71 | PTK2 | 0.71281375 |
| 72 | CSNK1G2 | 0.71089527 |
| 73 | BRAF | 0.70441388 |
| 74 | LIMK1 | 0.70212173 |
| 75 | ROCK1 | 0.69978970 |
| 76 | PAK2 | 0.69881200 |
| 77 | CAMK2D | 0.69009331 |
| 78 | PINK1 | 0.68135689 |
| 79 | DAPK1 | 0.67767924 |
| 80 | CAMK2G | 0.67733417 |
| 81 | WNK3 | 0.66229101 |
| 82 | RIPK4 | 0.64592199 |
| 83 | RIPK1 | 0.63891541 |
| 84 | INSRR | 0.62673593 |
| 85 | CAMKK2 | 0.62392144 |
| 86 | BRSK1 | 0.62114959 |
| 87 | CSNK1A1L | 0.62079488 |
| 88 | CAMK1G | 0.61581966 |
| 89 | STK11 | 0.61544146 |
| 90 | MET | 0.61119818 |
| 91 | SIK3 | 0.61074553 |
| 92 | RPS6KA2 | 0.60879521 |
| 93 | NEK6 | 0.60565614 |
| 94 | SGK3 | 0.60495990 |
| 95 | MAPK10 | 0.59821582 |
| 96 | FGFR1 | 0.59478960 |
| 97 | STK38 | 0.59471351 |
| 98 | DYRK1A | 0.59151494 |
| 99 | MAP2K1 | 0.58202389 |
| 100 | ERBB2 | 0.57151406 |
| 101 | SGK1 | 0.56373280 |
| 102 | DYRK1B | 0.55859846 |
| 103 | PRKCZ | 0.55454750 |
| 104 | FES | 0.55427533 |
| 105 | ALK | 0.55146807 |
| 106 | KDR | 0.53880407 |
| 107 | CDC42BPA | 0.53210533 |
| 108 | PRKD1 | 0.52667852 |
| 109 | PDPK1 | 0.52382453 |
| 110 | CSNK1E | 0.52294439 |
| 111 | FGR | 0.51794457 |
| 112 | FYN | 0.50983614 |
| 113 | GRK7 | 0.50216934 |
| 114 | MOS | 0.50031857 |
| 115 | ERBB3 | 0.48622892 |
| 116 | ADRBK1 | 0.48494636 |
| 117 | RPS6KA3 | 0.46468803 |
| 118 | TRIB3 | 0.46046262 |
| 119 | MUSK | 0.44994448 |
| 120 | BMPR2 | 0.44641820 |
| 121 | CAMK1D | 0.41042109 |
| 122 | PDGFRB | 0.39931907 |
| 123 | LATS1 | 0.39008663 |
| 124 | CAMK4 | 0.38538429 |
| 125 | DAPK3 | 0.38327615 |
| 126 | MTOR | 0.36965772 |
| 127 | PRKDC | 0.34800299 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.66769412 |
| 2 | Circadian entrainment_Homo sapiens_hsa04713 | 2.36895066 |
| 3 | GABAergic synapse_Homo sapiens_hsa04727 | 2.29611090 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.28089306 |
| 5 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.18378557 |
| 6 | Morphine addiction_Homo sapiens_hsa05032 | 2.11218784 |
| 7 | Olfactory transduction_Homo sapiens_hsa04740 | 2.09225341 |
| 8 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.09121296 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.08510126 |
| 10 | Long-term potentiation_Homo sapiens_hsa04720 | 2.05205177 |
| 11 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.92323551 |
| 12 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.91342562 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 1.89640772 |
| 14 | Insulin secretion_Homo sapiens_hsa04911 | 1.87933681 |
| 15 | Cocaine addiction_Homo sapiens_hsa05030 | 1.87628251 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.79898379 |
| 17 | Axon guidance_Homo sapiens_hsa04360 | 1.77592279 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.77417033 |
| 19 | Renin secretion_Homo sapiens_hsa04924 | 1.74084849 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.69611901 |
| 21 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.68488446 |
| 22 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.62919292 |
| 23 | Gap junction_Homo sapiens_hsa04540 | 1.57807445 |
| 24 | Taste transduction_Homo sapiens_hsa04742 | 1.53963432 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.52753753 |
| 26 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.50566295 |
| 27 | Long-term depression_Homo sapiens_hsa04730 | 1.50409049 |
| 28 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.36292312 |
| 29 | Melanogenesis_Homo sapiens_hsa04916 | 1.35401172 |
| 30 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.32122260 |
| 31 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.27802205 |
| 32 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.25333891 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.25117709 |
| 34 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.17439465 |
| 35 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.16560468 |
| 36 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.14927300 |
| 37 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.14596802 |
| 38 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.14212664 |
| 39 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.13450259 |
| 40 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 1.10677557 |
| 41 | Glioma_Homo sapiens_hsa05214 | 1.08719067 |
| 42 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.06070285 |
| 43 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.05742893 |
| 44 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.03038515 |
| 45 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.00755474 |
| 46 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.97540046 |
| 47 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.97120097 |
| 48 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.95460284 |
| 49 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.95182078 |
| 50 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.94790513 |
| 51 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.94643920 |
| 52 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.94104439 |
| 53 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.92729388 |
| 54 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.91665888 |
| 55 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.91239017 |
| 56 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.90583837 |
| 57 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.90491455 |
| 58 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.88254626 |
| 59 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.85482587 |
| 60 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.85359445 |
| 61 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.85303944 |
| 62 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.84931974 |
| 63 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.84827424 |
| 64 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.84754015 |
| 65 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.84308142 |
| 66 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.82439583 |
| 67 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.80721135 |
| 68 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.80399173 |
| 69 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.80214134 |
| 70 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.80149211 |
| 71 | Tight junction_Homo sapiens_hsa04530 | 0.79759440 |
| 72 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.74026560 |
| 73 | Focal adhesion_Homo sapiens_hsa04510 | 0.72472258 |
| 74 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.72285663 |
| 75 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.69395926 |
| 76 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.68334856 |
| 77 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.68290565 |
| 78 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.67753380 |
| 79 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.67352037 |
| 80 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.66318004 |
| 81 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.65620251 |
| 82 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65239956 |
| 83 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.65039479 |
| 84 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.64001836 |
| 85 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.63715344 |
| 86 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.63316716 |
| 87 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.61698922 |
| 88 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.61636100 |
| 89 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61150062 |
| 90 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.59590376 |
| 91 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.58544239 |
| 92 | Endocytosis_Homo sapiens_hsa04144 | 0.53409180 |
| 93 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.53368815 |
| 94 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.52867392 |
| 95 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.52613252 |
| 96 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.51640435 |
| 97 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.51335029 |
| 98 | Endometrial cancer_Homo sapiens_hsa05213 | 0.50990492 |
| 99 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.50887750 |
| 100 | Alzheimers disease_Homo sapiens_hsa05010 | 0.50727845 |
| 101 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.50190913 |
| 102 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.47885703 |
| 103 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.47751905 |
| 104 | Histidine metabolism_Homo sapiens_hsa00340 | 0.47414383 |
| 105 | Bile secretion_Homo sapiens_hsa04976 | 0.47338992 |
| 106 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.47285943 |
| 107 | Alcoholism_Homo sapiens_hsa05034 | 0.47140859 |
| 108 | Platelet activation_Homo sapiens_hsa04611 | 0.45754075 |
| 109 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.44581002 |
| 110 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.43927731 |
| 111 | Phototransduction_Homo sapiens_hsa04744 | 0.43336443 |
| 112 | Adherens junction_Homo sapiens_hsa04520 | 0.43329344 |
| 113 | PI3K-Akt signaling pathway_Homo sapiens_hsa04151 | 0.43221107 |
| 114 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.42573843 |
| 115 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.41890623 |
| 116 | Melanoma_Homo sapiens_hsa05218 | 0.40272610 |
| 117 | Prion diseases_Homo sapiens_hsa05020 | 0.40250328 |
| 118 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.39788466 |
| 119 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.39503501 |
| 120 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.38186145 |

