

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle maturation (GO:0016188) | 6.01775367 |
| 2 | layer formation in cerebral cortex (GO:0021819) | 5.99012363 |
| 3 | locomotory exploration behavior (GO:0035641) | 5.93678499 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.52492982 |
| 5 | vocalization behavior (GO:0071625) | 5.21696677 |
| 6 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.21014752 |
| 7 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.13685248 |
| 8 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.12977936 |
| 9 | dendritic spine morphogenesis (GO:0060997) | 4.89797351 |
| 10 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.74553134 |
| 11 | exploration behavior (GO:0035640) | 4.69288742 |
| 12 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.67325050 |
| 13 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.65733590 |
| 14 | regulation of synapse structural plasticity (GO:0051823) | 4.65193490 |
| 15 | glutamate secretion (GO:0014047) | 4.61919920 |
| 16 | protein localization to synapse (GO:0035418) | 4.54625943 |
| 17 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.43242114 |
| 18 | synaptic vesicle exocytosis (GO:0016079) | 4.42712692 |
| 19 | neuron cell-cell adhesion (GO:0007158) | 4.34968130 |
| 20 | cell migration in hindbrain (GO:0021535) | 4.28983975 |
| 21 | positive regulation of synapse maturation (GO:0090129) | 4.22039064 |
| 22 | dendrite morphogenesis (GO:0048813) | 4.21338668 |
| 23 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.00301426 |
| 24 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.98264885 |
| 25 | proline transport (GO:0015824) | 3.98253222 |
| 26 | axonal fasciculation (GO:0007413) | 3.89648030 |
| 27 | postsynaptic membrane organization (GO:0001941) | 3.88247492 |
| 28 | neuron recognition (GO:0008038) | 3.88206550 |
| 29 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.88197735 |
| 30 | nucleobase catabolic process (GO:0046113) | 3.87327866 |
| 31 | neurotransmitter secretion (GO:0007269) | 3.86507015 |
| 32 | planar cell polarity pathway involved in neural tube closure (GO:0090179) | 3.80461478 |
| 33 | regulation of synaptic vesicle transport (GO:1902803) | 3.79296704 |
| 34 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.76080937 |
| 35 | activation of protein kinase A activity (GO:0034199) | 3.73543079 |
| 36 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.72585249 |
| 37 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.61679249 |
| 38 | neuromuscular process controlling balance (GO:0050885) | 3.61241552 |
| 39 | gamma-aminobutyric acid transport (GO:0015812) | 3.60679720 |
| 40 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.60364426 |
| 41 | auditory behavior (GO:0031223) | 3.55916854 |
| 42 | presynaptic membrane assembly (GO:0097105) | 3.54988111 |
| 43 | clathrin coat assembly (GO:0048268) | 3.51956869 |
| 44 | cell communication by electrical coupling (GO:0010644) | 3.47133424 |
| 45 | presynaptic membrane organization (GO:0097090) | 3.44871337 |
| 46 | cerebellar Purkinje cell layer development (GO:0021680) | 3.40131256 |
| 47 | regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) | 3.39425577 |
| 48 | establishment of nucleus localization (GO:0040023) | 3.39409676 |
| 49 | sodium ion export (GO:0071436) | 3.39228211 |
| 50 | synaptic transmission, glutamatergic (GO:0035249) | 3.37029709 |
| 51 | cell-cell junction maintenance (GO:0045217) | 3.33545166 |
| 52 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.33366732 |
| 53 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.29962436 |
| 54 | mitochondrion transport along microtubule (GO:0047497) | 3.29962436 |
| 55 | dendritic spine organization (GO:0097061) | 3.29551469 |
| 56 | axon extension (GO:0048675) | 3.28547192 |
| 57 | convergent extension (GO:0060026) | 3.27180232 |
| 58 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 3.26140068 |
| 59 | positive regulation of membrane potential (GO:0045838) | 3.25765620 |
| 60 | glutamate receptor signaling pathway (GO:0007215) | 3.22284404 |
| 61 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.21321413 |
| 62 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.20776113 |
| 63 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.18151813 |
| 64 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.17678323 |
| 65 | long-term memory (GO:0007616) | 3.15990517 |
| 66 | positive regulation of axon extension (GO:0045773) | 3.15507072 |
| 67 | neuron projection extension involved in neuron projection guidance (GO:1902284) | 3.14292926 |
| 68 | axon extension involved in axon guidance (GO:0048846) | 3.14292926 |
| 69 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.10159262 |
| 70 | positive regulation of dendritic spine development (GO:0060999) | 3.09023149 |
| 71 | cellular potassium ion homeostasis (GO:0030007) | 3.08344494 |
| 72 | response to auditory stimulus (GO:0010996) | 3.08207945 |
| 73 | negative regulation of microtubule polymerization (GO:0031115) | 3.07844666 |
| 74 | regulation of synapse maturation (GO:0090128) | 3.07763243 |
| 75 | organelle transport along microtubule (GO:0072384) | 3.05596533 |
| 76 | positive regulation of synapse assembly (GO:0051965) | 3.05372357 |
| 77 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.02614178 |
| 78 | camera-type eye morphogenesis (GO:0048593) | 3.01424317 |
| 79 | establishment of mitochondrion localization (GO:0051654) | 3.00895833 |
| 80 | regulation of synaptic plasticity (GO:0048167) | 3.00141477 |
| 81 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.99218253 |
| 82 | regulation of dendritic spine development (GO:0060998) | 2.99061911 |
| 83 | spinal cord development (GO:0021510) | 2.98850137 |
| 84 | neuron projection extension (GO:1990138) | 2.98539926 |
| 85 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.98196080 |
| 86 | neuron-neuron synaptic transmission (GO:0007270) | 2.97787815 |
| 87 | synapse assembly (GO:0007416) | 2.94930034 |
| 88 | transmission of nerve impulse (GO:0019226) | 2.94477946 |
| 89 | innervation (GO:0060384) | 2.93975707 |
| 90 | dopamine receptor signaling pathway (GO:0007212) | 2.93713613 |
| 91 | cytoskeletal anchoring at plasma membrane (GO:0007016) | 2.93528818 |
| 92 | regulation of postsynaptic membrane potential (GO:0060078) | 2.93406807 |
| 93 | neuronal ion channel clustering (GO:0045161) | 2.93242202 |
| 94 | regulation of ARF protein signal transduction (GO:0032012) | 2.90397338 |
| 95 | prepulse inhibition (GO:0060134) | 2.90041702 |
| 96 | synapse organization (GO:0050808) | 2.89643600 |
| 97 | central nervous system neuron axonogenesis (GO:0021955) | 2.88833990 |
| 98 | cerebellar granule cell differentiation (GO:0021707) | 2.87125299 |
| 99 | axon cargo transport (GO:0008088) | 2.85690616 |
| 100 | cranial nerve morphogenesis (GO:0021602) | 2.85546260 |
| 101 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.85305341 |
| 102 | vesicle transport along microtubule (GO:0047496) | 2.85098821 |
| 103 | regulation of neurotransmitter secretion (GO:0046928) | 2.83393083 |
| 104 | neurotransmitter transport (GO:0006836) | 2.83219535 |
| 105 | cerebellum development (GO:0021549) | 2.82332706 |
| 106 | regulation of axon extension (GO:0030516) | 2.80093477 |
| 107 | synaptic vesicle endocytosis (GO:0048488) | 2.79637836 |
| 108 | neuromuscular process (GO:0050905) | 2.77125807 |
| 109 | glycine transport (GO:0015816) | 2.76501314 |
| 110 | social behavior (GO:0035176) | 2.74789783 |
| 111 | intraspecies interaction between organisms (GO:0051703) | 2.74789783 |
| 112 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.74576107 |
| 113 | negative regulation of catenin import into nucleus (GO:0035414) | 2.74030445 |
| 114 | positive regulation of dendrite development (GO:1900006) | 2.71254196 |
| 115 | cell communication involved in cardiac conduction (GO:0086065) | 2.68619555 |
| 116 | neuronal action potential propagation (GO:0019227) | 2.68522056 |
| 117 | body morphogenesis (GO:0010171) | 2.66990665 |
| 118 | cell junction maintenance (GO:0034331) | 2.65301795 |
| 119 | Wnt signaling pathway, planar cell polarity pathway (GO:0060071) | 2.61822462 |
| 120 | regulation of glycogen (starch) synthase activity (GO:2000465) | 2.55358941 |
| 121 | behavioral response to nicotine (GO:0035095) | 2.54993054 |
| 122 | regulation of respiratory system process (GO:0044065) | 2.53981195 |
| 123 | axon ensheathment in central nervous system (GO:0032291) | 2.52460077 |
| 124 | central nervous system myelination (GO:0022010) | 2.52460077 |
| 125 | skeletal muscle organ development (GO:0060538) | 2.49692125 |
| 126 | developmental cell growth (GO:0048588) | 2.49271237 |
| 127 | regulation of axon extension involved in axon guidance (GO:0048841) | 2.47758003 |
| 128 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.46067604 |
| 129 | apical protein localization (GO:0045176) | 2.46060392 |
| 130 | response to parathyroid hormone (GO:0071107) | 2.44735278 |
| 131 | mating behavior (GO:0007617) | 2.42879330 |
| 132 | regulation of establishment of planar polarity (GO:0090175) | 2.42002306 |
| 133 | regulation of synapse assembly (GO:0051963) | 2.41674602 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.00875007 |
| 2 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.40533588 |
| 3 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.99108730 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.85978347 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.83441873 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.79113517 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.79113517 |
| 8 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.79048582 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.65181272 |
| 10 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.63176640 |
| 11 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.61921014 |
| 12 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.56964062 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.44364978 |
| 14 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.43811954 |
| 15 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.43379947 |
| 16 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.41939846 |
| 17 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.41179181 |
| 18 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.38305341 |
| 19 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.36792040 |
| 20 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.34365364 |
| 21 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.34076061 |
| 22 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.32917284 |
| 23 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.29158080 |
| 24 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 2.22668692 |
| 25 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.19768813 |
| 26 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 2.17695242 |
| 27 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.15689867 |
| 28 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 2.08360561 |
| 29 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.06336489 |
| 30 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.93311862 |
| 31 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.90161450 |
| 32 | KDM2B_26808549_Chip-Seq_K562_Human | 1.86011350 |
| 33 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.84476217 |
| 34 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.81018509 |
| 35 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.69403056 |
| 36 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.62777352 |
| 37 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.60533352 |
| 38 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.58513009 |
| 39 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.57280901 |
| 40 | * ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.55601750 |
| 41 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.52614270 |
| 42 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.51030841 |
| 43 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 1.48927897 |
| 44 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.43048652 |
| 45 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.42215249 |
| 46 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.40953700 |
| 47 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.39452790 |
| 48 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.35939107 |
| 49 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.35320486 |
| 50 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.33878555 |
| 51 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.33323751 |
| 52 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.33060740 |
| 53 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.30925492 |
| 54 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.26787599 |
| 55 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.26154209 |
| 56 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.25756352 |
| 57 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.24861699 |
| 58 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.24434263 |
| 59 | * DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 1.23658096 |
| 60 | AR_19668381_ChIP-Seq_PC3_Human | 1.20128893 |
| 61 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.19870467 |
| 62 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.19372111 |
| 63 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.19299234 |
| 64 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.18864318 |
| 65 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.18717392 |
| 66 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.17375432 |
| 67 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.16514525 |
| 68 | LXR_22292898_ChIP-Seq_THP-1_Human | 1.14763447 |
| 69 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.14174848 |
| 70 | P68_20966046_ChIP-Seq_HELA_Human | 1.12001093 |
| 71 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.11804789 |
| 72 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.11347216 |
| 73 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.10772516 |
| 74 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 1.10025242 |
| 75 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.09142081 |
| 76 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.08166094 |
| 77 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.07374100 |
| 78 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 1.06686891 |
| 79 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.05423662 |
| 80 | SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.05387381 |
| 81 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.04893117 |
| 82 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 1.04359563 |
| 83 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.03964392 |
| 84 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.03753936 |
| 85 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.01220784 |
| 86 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 0.99482968 |
| 87 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.99001884 |
| 88 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.98808484 |
| 89 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 0.97853586 |
| 90 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.97731318 |
| 91 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.97408804 |
| 92 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 0.97071174 |
| 93 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 0.97059074 |
| 94 | AHR_22903824_ChIP-Seq_MCF-7_Human | 0.96666728 |
| 95 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 0.95277843 |
| 96 | * SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.94788229 |
| 97 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 0.94316380 |
| 98 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.93954428 |
| 99 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.92906792 |
| 100 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.92037451 |
| 101 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 0.91956838 |
| 102 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.91903691 |
| 103 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.91592345 |
| 104 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.91301139 |
| 105 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.91161160 |
| 106 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.90697185 |
| 107 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.90651727 |
| 108 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.90135602 |
| 109 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.89998820 |
| 110 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.86831956 |
| 111 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.85708240 |
| 112 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.85597220 |
| 113 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.85465162 |
| 114 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.85379823 |
| 115 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 0.84718226 |
| 116 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 0.84547342 |
| 117 | RUNX1_26923725_Chip-Seq_HPCs_Mouse | 0.84376217 |
| 118 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.84156449 |
| 119 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 0.83891540 |
| 120 | STAT3_19079543_ChIP-ChIP_MESCs_Mouse | 0.83790017 |
| 121 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.83777767 |
| 122 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.83753325 |
| 123 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 0.83691254 |
| 124 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.83401909 |
| 125 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.82270199 |
| 126 | TP53_23651856_ChIP-Seq_MEFs_Mouse | 0.82222864 |
| 127 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.81285508 |
| 128 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.80764203 |
| 129 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.80519416 |
| 130 | AR_25329375_ChIP-Seq_VCAP_Human | 0.80173626 |
| 131 | * MYC_27129775_Chip-Seq_CORNEA_Mouse | 0.80160963 |
| 132 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 0.79684829 |
| 133 | SMC4_20622854_ChIP-Seq_HELA_Human | 0.79360450 |
| 134 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.78509541 |
| 135 | TP53_16413492_ChIP-PET_HCT116_Human | 0.78259163 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.63265333 |
| 2 | MP0004270_analgesia | 4.18426359 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.87265594 |
| 4 | MP0003880_abnormal_central_pattern | 3.18929213 |
| 5 | MP0002063_abnormal_learning/memory/cond | 3.15060986 |
| 6 | MP0005423_abnormal_somatic_nervous | 3.01699395 |
| 7 | MP0009780_abnormal_chondrocyte_physiolo | 2.76164132 |
| 8 | MP0009745_abnormal_behavioral_response | 2.75252976 |
| 9 | MP0004858_abnormal_nervous_system | 2.67702164 |
| 10 | MP0002734_abnormal_mechanical_nocicepti | 2.66005362 |
| 11 | MP0000778_abnormal_nervous_system | 2.53235960 |
| 12 | MP0002064_seizures | 2.40065614 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.38361941 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.26085609 |
| 15 | MP0009046_muscle_twitch | 2.16291379 |
| 16 | MP0004811_abnormal_neuron_physiology | 2.06606533 |
| 17 | MP0002184_abnormal_innervation | 2.05560862 |
| 18 | MP0002733_abnormal_thermal_nociception | 2.00809074 |
| 19 | MP0003121_genomic_imprinting | 2.00315066 |
| 20 | MP0003329_amyloid_beta_deposits | 1.98447380 |
| 21 | MP0001486_abnormal_startle_reflex | 1.96147404 |
| 22 | MP0000955_abnormal_spinal_cord | 1.88110575 |
| 23 | MP0002735_abnormal_chemical_nociception | 1.87529104 |
| 24 | MP0010030_abnormal_orbit_morphology | 1.85574574 |
| 25 | MP0002822_catalepsy | 1.85503587 |
| 26 | MP0002249_abnormal_larynx_morphology | 1.83434719 |
| 27 | MP0001440_abnormal_grooming_behavior | 1.78254709 |
| 28 | MP0006292_abnormal_olfactory_placode | 1.77572509 |
| 29 | MP0000569_abnormal_digit_pigmentation | 1.77068592 |
| 30 | MP0002909_abnormal_adrenal_gland | 1.73252227 |
| 31 | MP0004885_abnormal_endolymph | 1.70961310 |
| 32 | MP0001970_abnormal_pain_threshold | 1.69958720 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.66862729 |
| 34 | MP0002736_abnormal_nociception_after | 1.66352796 |
| 35 | MP0002272_abnormal_nervous_system | 1.64516413 |
| 36 | MP0008569_lethality_at_weaning | 1.60799326 |
| 37 | MP0000751_myopathy | 1.59151956 |
| 38 | MP0000049_abnormal_middle_ear | 1.55189435 |
| 39 | MP0009379_abnormal_foot_pigmentation | 1.53432794 |
| 40 | MP0003283_abnormal_digestive_organ | 1.52860743 |
| 41 | MP0000566_synostosis | 1.51388049 |
| 42 | MP0005386_behavior/neurological_phenoty | 1.48716854 |
| 43 | MP0004924_abnormal_behavior | 1.48716854 |
| 44 | MP0005623_abnormal_meninges_morphology | 1.47872606 |
| 45 | MP0002882_abnormal_neuron_morphology | 1.46911130 |
| 46 | MP0002067_abnormal_sensory_capabilities | 1.45837019 |
| 47 | MP0001348_abnormal_lacrimal_gland | 1.43965358 |
| 48 | MP0000537_abnormal_urethra_morphology | 1.38075330 |
| 49 | MP0003122_maternal_imprinting | 1.37203639 |
| 50 | MP0001188_hyperpigmentation | 1.35192953 |
| 51 | MP0001501_abnormal_sleep_pattern | 1.33895265 |
| 52 | MP0002152_abnormal_brain_morphology | 1.33734151 |
| 53 | MP0003879_abnormal_hair_cell | 1.33160031 |
| 54 | MP0002066_abnormal_motor_capabilities/c | 1.30484931 |
| 55 | MP0003787_abnormal_imprinting | 1.29428706 |
| 56 | MP0003938_abnormal_ear_development | 1.28764044 |
| 57 | MP0009053_abnormal_anal_canal | 1.21048441 |
| 58 | MP0005187_abnormal_penis_morphology | 1.19782682 |
| 59 | MP0004233_abnormal_muscle_weight | 1.16240380 |
| 60 | MP0004133_heterotaxia | 1.14049427 |
| 61 | MP0008961_abnormal_basal_metabolism | 1.13731323 |
| 62 | MP0004145_abnormal_muscle_electrophysio | 1.11027756 |
| 63 | MP0002234_abnormal_pharynx_morphology | 1.10974284 |
| 64 | MP0010234_abnormal_vibrissa_follicle | 1.09147671 |
| 65 | MP0001529_abnormal_vocalization | 1.08714295 |
| 66 | MP0003861_abnormal_nervous_system | 1.08210078 |
| 67 | MP0003633_abnormal_nervous_system | 1.07136473 |
| 68 | MP0003937_abnormal_limbs/digits/tail_de | 1.07075283 |
| 69 | MP0002697_abnormal_eye_size | 1.06411216 |
| 70 | MP0001293_anophthalmia | 1.05462679 |
| 71 | MP0001346_abnormal_lacrimal_gland | 1.04362925 |
| 72 | MP0003705_abnormal_hypodermis_morpholog | 1.04042037 |
| 73 | MP0002116_abnormal_craniofacial_bone | 1.03207409 |
| 74 | MP0005409_darkened_coat_color | 1.01954800 |
| 75 | MP0006276_abnormal_autonomic_nervous | 1.00907145 |
| 76 | MP0000428_abnormal_craniofacial_morphol | 0.96349050 |
| 77 | MP0000534_abnormal_ureter_morphology | 0.96059295 |
| 78 | MP0001299_abnormal_eye_distance/ | 0.95795300 |
| 79 | MP0002233_abnormal_nose_morphology | 0.95470900 |
| 80 | MP0003755_abnormal_palate_morphology | 0.95455983 |
| 81 | MP0002092_abnormal_eye_morphology | 0.95204787 |
| 82 | MP0003119_abnormal_digestive_system | 0.94653956 |
| 83 | MP0000026_abnormal_inner_ear | 0.94634694 |
| 84 | MP0003631_nervous_system_phenotype | 0.94040668 |
| 85 | MP0003136_yellow_coat_color | 0.91462667 |
| 86 | MP0002163_abnormal_gland_morphology | 0.91368008 |
| 87 | MP0001177_atelectasis | 0.90751563 |
| 88 | MP0003137_abnormal_impulse_conducting | 0.90400529 |
| 89 | MP0002638_abnormal_pupillary_reflex | 0.90221001 |
| 90 | MP0000631_abnormal_neuroendocrine_gland | 0.88527682 |
| 91 | MP0003634_abnormal_glial_cell | 0.88321566 |
| 92 | MP0004085_abnormal_heartbeat | 0.87975185 |
| 93 | MP0009250_abnormal_appendicular_skeleto | 0.87936163 |
| 94 | MP0008789_abnormal_olfactory_epithelium | 0.86946437 |
| 95 | MP0001984_abnormal_olfaction | 0.86338551 |
| 96 | MP0005257_abnormal_intraocular_pressure | 0.86160428 |
| 97 | MP0002089_abnormal_postnatal_growth/wei | 0.86133966 |
| 98 | MP0002069_abnormal_eating/drinking_beha | 0.85659622 |
| 99 | MP0000013_abnormal_adipose_tissue | 0.84818661 |
| 100 | MP0005499_abnormal_olfactory_system | 0.84755833 |
| 101 | MP0005394_taste/olfaction_phenotype | 0.84755833 |
| 102 | MP0004130_abnormal_muscle_cell | 0.83793702 |
| 103 | MP0001286_abnormal_eye_development | 0.83074467 |
| 104 | MP0003385_abnormal_body_wall | 0.82964702 |
| 105 | MP0009672_abnormal_birth_weight | 0.79751514 |
| 106 | MP0001502_abnormal_circadian_rhythm | 0.79679222 |
| 107 | MP0005645_abnormal_hypothalamus_physiol | 0.78746756 |
| 108 | MP0004142_abnormal_muscle_tone | 0.78572078 |
| 109 | MP0003115_abnormal_respiratory_system | 0.77628364 |
| 110 | MP0003632_abnormal_nervous_system | 0.75579843 |
| 111 | MP0003935_abnormal_craniofacial_develop | 0.75203745 |
| 112 | MP0001905_abnormal_dopamine_level | 0.75185240 |
| 113 | MP0000604_amyloidosis | 0.73773180 |
| 114 | MP0002081_perinatal_lethality | 0.72926880 |
| 115 | MP0002752_abnormal_somatic_nervous | 0.71413592 |
| 116 | MP0003303_peritoneal_inflammation | 0.70331551 |
| 117 | MP0003075_altered_response_to | 0.69670231 |
| 118 | MP0002653_abnormal_ependyma_morphology | 0.69230903 |
| 119 | MP0003942_abnormal_urinary_system | 0.67977608 |
| 120 | MP0005646_abnormal_pituitary_gland | 0.67203053 |
| 121 | MP0001943_abnormal_respiration | 0.66567016 |
| 122 | MP0003123_paternal_imprinting | 0.65964186 |
| 123 | MP0000747_muscle_weakness | 0.65275135 |
| 124 | MP0005167_abnormal_blood-brain_barrier | 0.65044369 |
| 125 | MP0005248_abnormal_Harderian_gland | 0.64398328 |
| 126 | MP0005076_abnormal_cell_differentiation | 0.63386357 |
| 127 | MP0010769_abnormal_survival | 0.62092190 |
| 128 | MP0004215_abnormal_myocardial_fiber | 0.61683238 |
| 129 | MP0008874_decreased_physiological_sensi | 0.61486315 |
| 130 | MP0004087_abnormal_muscle_fiber | 0.59733327 |
| 131 | MP0002896_abnormal_bone_mineralization | 0.58740477 |
| 132 | MP0002082_postnatal_lethality | 0.58652529 |
| 133 | MP0010770_preweaning_lethality | 0.58652529 |
| 134 | MP0010768_mortality/aging | 0.56856002 |
| 135 | MP0001849_ear_inflammation | 0.56683246 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 5.21673000 |
| 2 | Visual hallucinations (HP:0002367) | 3.95780313 |
| 3 | Focal motor seizures (HP:0011153) | 3.83562985 |
| 4 | Focal seizures (HP:0007359) | 3.77207732 |
| 5 | Papilledema (HP:0001085) | 3.67672399 |
| 6 | Mutism (HP:0002300) | 3.64636405 |
| 7 | Supranuclear gaze palsy (HP:0000605) | 3.53679024 |
| 8 | Ankle clonus (HP:0011448) | 3.32966828 |
| 9 | Akinesia (HP:0002304) | 3.13899813 |
| 10 | Amyotrophic lateral sclerosis (HP:0007354) | 3.10606040 |
| 11 | Abnormality of the lower motor neuron (HP:0002366) | 3.06781601 |
| 12 | Turricephaly (HP:0000262) | 3.06494494 |
| 13 | Insomnia (HP:0100785) | 3.05174824 |
| 14 | Epileptic encephalopathy (HP:0200134) | 3.00479364 |
| 15 | Action tremor (HP:0002345) | 2.99913664 |
| 16 | Fetal akinesia sequence (HP:0001989) | 2.95015525 |
| 17 | Hyperacusis (HP:0010780) | 2.85755241 |
| 18 | Poor eye contact (HP:0000817) | 2.82771133 |
| 19 | Progressive cerebellar ataxia (HP:0002073) | 2.73648310 |
| 20 | Cerebral inclusion bodies (HP:0100314) | 2.69357680 |
| 21 | Megalencephaly (HP:0001355) | 2.69305591 |
| 22 | Torticollis (HP:0000473) | 2.68222862 |
| 23 | Pointed chin (HP:0000307) | 2.67708591 |
| 24 | Termporal pattern (HP:0011008) | 2.66569309 |
| 25 | Insidious onset (HP:0003587) | 2.66569309 |
| 26 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.65716467 |
| 27 | Abnormality of the corticospinal tract (HP:0002492) | 2.63116392 |
| 28 | Genetic anticipation (HP:0003743) | 2.62882347 |
| 29 | Obstructive sleep apnea (HP:0002870) | 2.62322248 |
| 30 | Depression (HP:0000716) | 2.59100988 |
| 31 | Broad-based gait (HP:0002136) | 2.58662048 |
| 32 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.56382193 |
| 33 | Impaired social interactions (HP:0000735) | 2.55888502 |
| 34 | Abnormal social behavior (HP:0012433) | 2.55888502 |
| 35 | Urinary urgency (HP:0000012) | 2.54983957 |
| 36 | Elfin facies (HP:0004428) | 2.52186905 |
| 37 | Neurofibrillary tangles (HP:0002185) | 2.49540595 |
| 38 | Excessive salivation (HP:0003781) | 2.46456365 |
| 39 | Drooling (HP:0002307) | 2.46456365 |
| 40 | Hyperthyroidism (HP:0000836) | 2.43778058 |
| 41 | Apathy (HP:0000741) | 2.42488660 |
| 42 | Abnormality of the aortic arch (HP:0012303) | 2.42336899 |
| 43 | Shallow orbits (HP:0000586) | 2.40616200 |
| 44 | Limb dystonia (HP:0002451) | 2.40352187 |
| 45 | Lower limb amyotrophy (HP:0007210) | 2.39082835 |
| 46 | Focal dystonia (HP:0004373) | 2.33096055 |
| 47 | Partial duplication of thumb phalanx (HP:0009944) | 2.32468886 |
| 48 | Overriding aorta (HP:0002623) | 2.31332002 |
| 49 | High anterior hairline (HP:0009890) | 2.28477890 |
| 50 | Inappropriate behavior (HP:0000719) | 2.27871095 |
| 51 | Generalized tonic-clonic seizures (HP:0002069) | 2.27608901 |
| 52 | Renal duplication (HP:0000075) | 2.26879924 |
| 53 | Amblyopia (HP:0000646) | 2.25489995 |
| 54 | Partial duplication of the phalanx of hand (HP:0009999) | 2.24771212 |
| 55 | Hemiparesis (HP:0001269) | 2.22336220 |
| 56 | Aplasia involving bones of the extremities (HP:0009825) | 2.18968220 |
| 57 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.18968220 |
| 58 | Aplasia of the phalanges of the hand (HP:0009802) | 2.18968220 |
| 59 | Absence seizures (HP:0002121) | 2.18311787 |
| 60 | Renovascular hypertension (HP:0100817) | 2.17491455 |
| 61 | Diminished motivation (HP:0000745) | 2.16983737 |
| 62 | Ankyloglossia (HP:0010296) | 2.16650279 |
| 63 | Craniofacial dystonia (HP:0012179) | 2.15251847 |
| 64 | Stereotypic behavior (HP:0000733) | 2.14244155 |
| 65 | Postural instability (HP:0002172) | 2.14129537 |
| 66 | Hemiplegia (HP:0002301) | 2.14111457 |
| 67 | Atonic seizures (HP:0010819) | 2.13809834 |
| 68 | Abnormal eating behavior (HP:0100738) | 2.13768565 |
| 69 | Diastasis recti (HP:0001540) | 2.10021955 |
| 70 | Cutaneous syndactyly (HP:0012725) | 2.09302373 |
| 71 | Calcaneovalgus deformity (HP:0001848) | 2.09057072 |
| 72 | Spastic gait (HP:0002064) | 2.08392119 |
| 73 | Hepatoblastoma (HP:0002884) | 2.07142417 |
| 74 | Overgrowth (HP:0001548) | 2.06556625 |
| 75 | Trigonocephaly (HP:0000243) | 2.06134522 |
| 76 | Lower limb muscle weakness (HP:0007340) | 2.05921313 |
| 77 | Abnormality of binocular vision (HP:0011514) | 2.04857518 |
| 78 | Diplopia (HP:0000651) | 2.04857518 |
| 79 | Anxiety (HP:0000739) | 2.03756661 |
| 80 | Coronal craniosynostosis (HP:0004440) | 2.02698357 |
| 81 | Agitation (HP:0000713) | 2.02598996 |
| 82 | Truncus arteriosus (HP:0001660) | 2.01987726 |
| 83 | Abnormality of the 4th metacarpal (HP:0010012) | 2.00475877 |
| 84 | Sleep apnea (HP:0010535) | 1.98189980 |
| 85 | Pachygyria (HP:0001302) | 1.98048897 |
| 86 | Rib fusion (HP:0000902) | 1.98002559 |
| 87 | Dysdiadochokinesis (HP:0002075) | 1.97522501 |
| 88 | Annular pancreas (HP:0001734) | 1.96928786 |
| 89 | Cutaneous finger syndactyly (HP:0010554) | 1.96591561 |
| 90 | Neoplasm of the heart (HP:0100544) | 1.96240497 |
| 91 | Truncal ataxia (HP:0002078) | 1.95100606 |
| 92 | Bronchomalacia (HP:0002780) | 1.94834267 |
| 93 | Septo-optic dysplasia (HP:0100842) | 1.94477915 |
| 94 | Macroorchidism (HP:0000053) | 1.94270423 |
| 95 | Sacral dimple (HP:0000960) | 1.94043119 |
| 96 | Hypoplasia of the brainstem (HP:0002365) | 1.93967845 |
| 97 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 1.93967845 |
| 98 | Ventricular fibrillation (HP:0001663) | 1.93437932 |
| 99 | Febrile seizures (HP:0002373) | 1.93159431 |
| 100 | Shawl scrotum (HP:0000049) | 1.92457670 |
| 101 | Aqueductal stenosis (HP:0002410) | 1.91442743 |
| 102 | Flat cornea (HP:0007720) | 1.91394499 |
| 103 | Megalocornea (HP:0000485) | 1.87862477 |
| 104 | Thin ribs (HP:0000883) | 1.87554932 |
| 105 | Dialeptic seizures (HP:0011146) | 1.86956227 |
| 106 | Hypsarrhythmia (HP:0002521) | 1.85769178 |
| 107 | Intention tremor (HP:0002080) | 1.85044921 |
| 108 | EEG with generalized epileptiform discharges (HP:0011198) | 1.84235135 |
| 109 | Double outlet right ventricle (HP:0001719) | 1.82537069 |
| 110 | Congenital malformation of the right heart (HP:0011723) | 1.82537069 |
| 111 | Dysmetria (HP:0001310) | 1.82535353 |
| 112 | Abnormality of the diencephalon (HP:0010662) | 1.82253900 |
| 113 | Impaired smooth pursuit (HP:0007772) | 1.82180456 |
| 114 | Bowel diverticulosis (HP:0005222) | 1.81776116 |
| 115 | Deformed tarsal bones (HP:0008119) | 1.81407618 |
| 116 | Polyphagia (HP:0002591) | 1.81153167 |
| 117 | Difficulty running (HP:0009046) | 1.81090985 |
| 118 | Epileptiform EEG discharges (HP:0011182) | 1.80919904 |
| 119 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.80731022 |
| 120 | Short 4th metacarpal (HP:0010044) | 1.80593067 |
| 121 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.80593067 |
| 122 | Bradykinesia (HP:0002067) | 1.80225987 |
| 123 | Ulnar bowing (HP:0003031) | 1.79161302 |
| 124 | Deep palmar crease (HP:0006191) | 1.78949736 |
| 125 | Intellectual disability, profound (HP:0002187) | 1.78364539 |
| 126 | Progressive inability to walk (HP:0002505) | 1.78041891 |
| 127 | Broad metatarsal (HP:0001783) | 1.77444524 |
| 128 | Broad distal phalanx of finger (HP:0009836) | 1.77414075 |
| 129 | Hypoventilation (HP:0002791) | 1.77321287 |
| 130 | Adducted thumb (HP:0001181) | 1.76328764 |
| 131 | Genu recurvatum (HP:0002816) | 1.75366141 |
| 132 | Enlarged penis (HP:0000040) | 1.74698946 |
| 133 | Arnold-Chiari malformation (HP:0002308) | 1.73804958 |
| 134 | Lower limb asymmetry (HP:0100559) | 1.73690999 |
| 135 | Abnormality of the calcaneus (HP:0008364) | 1.72707017 |
| 136 | Generalized hypotonia (HP:0001290) | 1.72688734 |
| 137 | Bladder diverticulum (HP:0000015) | 1.72683153 |
| 138 | Gaze-evoked nystagmus (HP:0000640) | 1.72317125 |
| 139 | Patellar dislocation (HP:0002999) | 1.72264589 |
| 140 | Abnormal number of incisors (HP:0011064) | 1.67008017 |
| 141 | Broad thumb (HP:0011304) | 1.64700872 |
| 142 | Broad phalanges of the hand (HP:0009768) | 1.63431091 |
| 143 | Anophthalmia (HP:0000528) | 1.63089100 |
| 144 | Vitreoretinal degeneration (HP:0000655) | 1.61984918 |
| 145 | Broad finger (HP:0001500) | 1.60597533 |
| 146 | Long palpebral fissure (HP:0000637) | 1.60484638 |
| 147 | Asymmetric growth (HP:0100555) | 1.58254037 |
| 148 | Spina bifida occulta (HP:0003298) | 1.57978031 |
| 149 | Deviation of the hallux (HP:0010051) | 1.56984987 |
| 150 | Hypercalcemia (HP:0003072) | 1.55558515 |
| 151 | Cortical dysplasia (HP:0002539) | 1.54342868 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MARK1 | 6.12794786 |
| 2 | MAP3K9 | 4.08375582 |
| 3 | NTRK3 | 2.90654093 |
| 4 | EPHA4 | 2.86250015 |
| 5 | MINK1 | 2.63223906 |
| 6 | PAK6 | 2.43534088 |
| 7 | DAPK2 | 2.34847768 |
| 8 | LATS2 | 2.32076558 |
| 9 | MAP3K4 | 2.26902613 |
| 10 | NTRK2 | 2.16051071 |
| 11 | PRKD3 | 2.13597373 |
| 12 | CAMKK1 | 2.02237010 |
| 13 | KSR2 | 1.97099745 |
| 14 | PHKG1 | 1.95785816 |
| 15 | PHKG2 | 1.95785816 |
| 16 | KSR1 | 1.88361123 |
| 17 | TRIB3 | 1.86333215 |
| 18 | SIK2 | 1.84952596 |
| 19 | NTRK1 | 1.74629479 |
| 20 | TYRO3 | 1.55719558 |
| 21 | CDK5 | 1.48426838 |
| 22 | MAP2K7 | 1.48274301 |
| 23 | TAOK1 | 1.46401873 |
| 24 | MAPK13 | 1.44403337 |
| 25 | RIPK1 | 1.42814587 |
| 26 | PKN2 | 1.33967676 |
| 27 | DYRK2 | 1.31035951 |
| 28 | EPHB2 | 1.26764117 |
| 29 | ALK | 1.25412121 |
| 30 | MAP2K4 | 1.25289219 |
| 31 | ARAF | 1.22486476 |
| 32 | SCYL2 | 1.21888003 |
| 33 | RET | 1.15089654 |
| 34 | ERBB3 | 1.15033220 |
| 35 | MARK2 | 1.08582578 |
| 36 | CDK15 | 1.06927998 |
| 37 | BRAF | 1.06881983 |
| 38 | DAPK1 | 1.05308360 |
| 39 | MAP3K2 | 1.05261995 |
| 40 | CDK18 | 1.04588896 |
| 41 | SMG1 | 1.04073282 |
| 42 | CDK14 | 1.03256719 |
| 43 | ICK | 1.01735506 |
| 44 | UHMK1 | 1.00494912 |
| 45 | PLK2 | 0.99218230 |
| 46 | STK38 | 0.97650260 |
| 47 | STK11 | 0.97248274 |
| 48 | PAK3 | 0.97048555 |
| 49 | SIK1 | 0.96716704 |
| 50 | CAMK1D | 0.95055570 |
| 51 | CSNK1G2 | 0.94391349 |
| 52 | CDK11A | 0.94256878 |
| 53 | LMTK2 | 0.93319850 |
| 54 | DYRK1B | 0.92993234 |
| 55 | PRKCG | 0.89263953 |
| 56 | PDGFRA | 0.86771673 |
| 57 | DDR2 | 0.85701932 |
| 58 | PRPF4B | 0.78161590 |
| 59 | NEK1 | 0.76447845 |
| 60 | LIMK1 | 0.75519816 |
| 61 | PRKCH | 0.75194795 |
| 62 | MTOR | 0.73343551 |
| 63 | DMPK | 0.73112026 |
| 64 | RPS6KA2 | 0.69291485 |
| 65 | PRKCZ | 0.68751709 |
| 66 | GRK5 | 0.68669484 |
| 67 | MAP3K11 | 0.65317745 |
| 68 | CDK19 | 0.62353300 |
| 69 | AURKA | 0.60052926 |
| 70 | EEF2K | 0.59711458 |
| 71 | CAMK1 | 0.58974842 |
| 72 | FGFR2 | 0.58068443 |
| 73 | DYRK1A | 0.57657305 |
| 74 | CAMK1G | 0.55663181 |
| 75 | FYN | 0.54095585 |
| 76 | CAMK2A | 0.53945683 |
| 77 | CSNK1E | 0.53828646 |
| 78 | PKN1 | 0.52224093 |
| 79 | BCR | 0.51913708 |
| 80 | CAMKK2 | 0.51354450 |
| 81 | FGFR4 | 0.51007635 |
| 82 | MAPK12 | 0.50878643 |
| 83 | PNCK | 0.50761764 |
| 84 | TNIK | 0.50651793 |
| 85 | SGK2 | 0.50222181 |
| 86 | MAP3K10 | 0.47598258 |
| 87 | CDC42BPA | 0.47217123 |
| 88 | FER | 0.47095821 |
| 89 | ILK | 0.46870362 |
| 90 | DAPK3 | 0.46599859 |
| 91 | CAMK2B | 0.46212636 |
| 92 | MAP2K1 | 0.46173093 |
| 93 | ERBB2 | 0.46100338 |
| 94 | RAF1 | 0.45559107 |
| 95 | FES | 0.45346661 |
| 96 | AKT2 | 0.44640760 |
| 97 | ROCK1 | 0.44092830 |
| 98 | SGK1 | 0.44016141 |
| 99 | CSNK1G1 | 0.43952777 |
| 100 | BRSK1 | 0.43126446 |
| 101 | RPS6KA3 | 0.42679253 |
| 102 | PTK2 | 0.42610876 |
| 103 | CSNK1A1L | 0.41872447 |
| 104 | CSNK1G3 | 0.41867156 |
| 105 | CASK | 0.41756831 |
| 106 | RPS6KC1 | 0.41684538 |
| 107 | RPS6KL1 | 0.41684538 |
| 108 | MAPK10 | 0.41393831 |
| 109 | PRKCI | 0.41067569 |
| 110 | PDPK1 | 0.40587500 |
| 111 | MAP2K2 | 0.40469160 |
| 112 | MAP3K12 | 0.40452988 |
| 113 | PDK1 | 0.39762342 |
| 114 | GSK3B | 0.39257025 |
| 115 | MAPK8 | 0.39228247 |
| 116 | PRKAA1 | 0.39157282 |
| 117 | ABL2 | 0.39043761 |
| 118 | SGK3 | 0.38769843 |
| 119 | SGK223 | 0.38695303 |
| 120 | SGK494 | 0.38695303 |
| 121 | MAP3K7 | 0.38064672 |
| 122 | BMX | 0.37941284 |
| 123 | MAP2K6 | 0.37789379 |
| 124 | PTK6 | 0.37708082 |
| 125 | CAMK4 | 0.37306091 |
| 126 | MAP3K6 | 0.36795781 |
| 127 | MAPK9 | 0.36334818 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.64465642 |
| 2 | Nicotine addiction_Homo sapiens_hsa05033 | 2.48053764 |
| 3 | Circadian entrainment_Homo sapiens_hsa04713 | 2.34069675 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.33106047 |
| 5 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.27785196 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 2.17963779 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.16312576 |
| 8 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.12287193 |
| 9 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.97137512 |
| 10 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.95947208 |
| 11 | Morphine addiction_Homo sapiens_hsa05032 | 1.94491789 |
| 12 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.87035902 |
| 13 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.86823405 |
| 14 | Axon guidance_Homo sapiens_hsa04360 | 1.80725341 |
| 15 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.79981480 |
| 16 | Salivary secretion_Homo sapiens_hsa04970 | 1.77971657 |
| 17 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.73675645 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.70919533 |
| 19 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.68925577 |
| 20 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.66297840 |
| 21 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.61645517 |
| 22 | Insulin secretion_Homo sapiens_hsa04911 | 1.59450047 |
| 23 | Gap junction_Homo sapiens_hsa04540 | 1.57448520 |
| 24 | Glioma_Homo sapiens_hsa05214 | 1.55885250 |
| 25 | Cocaine addiction_Homo sapiens_hsa05030 | 1.49612333 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.45292305 |
| 27 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.44150856 |
| 28 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.43494749 |
| 29 | Long-term depression_Homo sapiens_hsa04730 | 1.42426026 |
| 30 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.41970998 |
| 31 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.33588128 |
| 32 | Melanogenesis_Homo sapiens_hsa04916 | 1.28828642 |
| 33 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.27861083 |
| 34 | Endometrial cancer_Homo sapiens_hsa05213 | 1.27625035 |
| 35 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.26557457 |
| 36 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.22444193 |
| 37 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.15579900 |
| 38 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.15385940 |
| 39 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.14993697 |
| 40 | Taste transduction_Homo sapiens_hsa04742 | 1.11782301 |
| 41 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.11384360 |
| 42 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 1.09592907 |
| 43 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 1.06485311 |
| 44 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 1.05519975 |
| 45 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 1.04224915 |
| 46 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.04099302 |
| 47 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.03683853 |
| 48 | mTOR signaling pathway_Homo sapiens_hsa04150 | 1.00327967 |
| 49 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.98945281 |
| 50 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.98381065 |
| 51 | Colorectal cancer_Homo sapiens_hsa05210 | 0.97643069 |
| 52 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.97504492 |
| 53 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.96150775 |
| 54 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.95789587 |
| 55 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.92872230 |
| 56 | Sulfur relay system_Homo sapiens_hsa04122 | 0.92848183 |
| 57 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.92745812 |
| 58 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.87619517 |
| 59 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.87075973 |
| 60 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.86427855 |
| 61 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.86232005 |
| 62 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.85244854 |
| 63 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.83502199 |
| 64 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.80154174 |
| 65 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.79695031 |
| 66 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.78449126 |
| 67 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.77787006 |
| 68 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.76999486 |
| 69 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.76614226 |
| 70 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.75629700 |
| 71 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.74641961 |
| 72 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.74590938 |
| 73 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.73682482 |
| 74 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.73246630 |
| 75 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.71574579 |
| 76 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.71522152 |
| 77 | Adherens junction_Homo sapiens_hsa04520 | 0.71458709 |
| 78 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.71295078 |
| 79 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.71091139 |
| 80 | Endocytosis_Homo sapiens_hsa04144 | 0.70994993 |
| 81 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.67495008 |
| 82 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.67476871 |
| 83 | Tight junction_Homo sapiens_hsa04530 | 0.67465195 |
| 84 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.67271395 |
| 85 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65865013 |
| 86 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.65675083 |
| 87 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.65329639 |
| 88 | Focal adhesion_Homo sapiens_hsa04510 | 0.64289893 |
| 89 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.63757784 |
| 90 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.63526655 |
| 91 | Alcoholism_Homo sapiens_hsa05034 | 0.63241427 |
| 92 | Melanoma_Homo sapiens_hsa05218 | 0.62400771 |
| 93 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.60732578 |
| 94 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.60202350 |
| 95 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.59583021 |
| 96 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.59317038 |
| 97 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.59011000 |
| 98 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.58754857 |
| 99 | Bile secretion_Homo sapiens_hsa04976 | 0.58189016 |
| 100 | Prion diseases_Homo sapiens_hsa05020 | 0.57000010 |
| 101 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.56575882 |
| 102 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.56215471 |
| 103 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.55410622 |
| 104 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.53728579 |
| 105 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.51896026 |
| 106 | Ribosome_Homo sapiens_hsa03010 | 0.50431329 |
| 107 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.49512328 |
| 108 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.48431516 |
| 109 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.48421575 |
| 110 | Phototransduction_Homo sapiens_hsa04744 | 0.48071765 |
| 111 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.48006583 |
| 112 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.47982403 |
| 113 | Platelet activation_Homo sapiens_hsa04611 | 0.46872931 |
| 114 | Pathways in cancer_Homo sapiens_hsa05200 | 0.46536278 |
| 115 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.44879799 |
| 116 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.44455362 |
| 117 | Amoebiasis_Homo sapiens_hsa05146 | 0.44402751 |
| 118 | Bladder cancer_Homo sapiens_hsa05219 | 0.43621660 |

