FAM171B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.45980395
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.22029655
3synaptic vesicle maturation (GO:0016188)5.20695572
4vocalization behavior (GO:0071625)5.12815010
5synaptic vesicle exocytosis (GO:0016079)5.08352881
6locomotory exploration behavior (GO:0035641)5.03257258
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90038965
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.88507635
9glutamate secretion (GO:0014047)4.81173251
10protein localization to synapse (GO:0035418)4.76854240
11neuron cell-cell adhesion (GO:0007158)4.75530410
12regulation of synaptic vesicle exocytosis (GO:2000300)4.68887658
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.55445010
14regulation of glutamate receptor signaling pathway (GO:1900449)4.52476377
15glutamate receptor signaling pathway (GO:0007215)4.29535476
16neuronal action potential propagation (GO:0019227)4.19600596
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.17550458
18regulation of neuronal synaptic plasticity (GO:0048168)4.16635742
19exploration behavior (GO:0035640)4.15414929
20regulation of synaptic vesicle transport (GO:1902803)4.13480588
21neurotransmitter-gated ion channel clustering (GO:0072578)4.09387245
22synaptic transmission, glutamatergic (GO:0035249)4.06517350
23regulation of long-term neuronal synaptic plasticity (GO:0048169)4.05264609
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.02371935
25pyrimidine nucleobase catabolic process (GO:0006208)3.99918142
26layer formation in cerebral cortex (GO:0021819)3.95418166
27neuron-neuron synaptic transmission (GO:0007270)3.93713647
28neurotransmitter secretion (GO:0007269)3.91036294
29dendritic spine morphogenesis (GO:0060997)3.90257131
30regulation of synapse structural plasticity (GO:0051823)3.85470709
31cellular potassium ion homeostasis (GO:0030007)3.82909622
32neuron recognition (GO:0008038)3.81672711
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.70269144
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67334465
35long-term memory (GO:0007616)3.66768267
36regulation of excitatory postsynaptic membrane potential (GO:0060079)3.63988428
37presynaptic membrane assembly (GO:0097105)3.60652620
38gamma-aminobutyric acid transport (GO:0015812)3.59496800
39G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.57914080
40long-term synaptic potentiation (GO:0060291)3.53894749
41L-amino acid import (GO:0043092)3.53157432
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.52327001
43transmission of nerve impulse (GO:0019226)3.52225762
44positive regulation of membrane potential (GO:0045838)3.50728150
45axonal fasciculation (GO:0007413)3.49753956
46regulation of postsynaptic membrane potential (GO:0060078)3.48595778
47nucleobase catabolic process (GO:0046113)3.45900783
48presynaptic membrane organization (GO:0097090)3.45842900
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45629470
50DNA double-strand break processing (GO:0000729)3.44991226
51regulation of dendritic spine morphogenesis (GO:0061001)3.44962955
52regulation of synaptic plasticity (GO:0048167)3.42966993
53positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40024398
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.39968801
55response to pheromone (GO:0019236)3.39946929
56synaptic vesicle endocytosis (GO:0048488)3.39201613
57postsynaptic membrane organization (GO:0001941)3.38022293
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36962905
59neurotransmitter transport (GO:0006836)3.36950078
60positive regulation of synapse maturation (GO:0090129)3.35043197
61C4-dicarboxylate transport (GO:0015740)3.33592547
62proline transport (GO:0015824)3.31295353
63negative regulation of dendrite development (GO:2000171)3.28720585
64sodium ion export (GO:0071436)3.28077271
65response to histamine (GO:0034776)3.27541429
66regulation of neurotransmitter secretion (GO:0046928)3.24257590
67cerebral cortex radially oriented cell migration (GO:0021799)3.22054185
68startle response (GO:0001964)3.20840481
69auditory behavior (GO:0031223)3.20743145
70dendrite morphogenesis (GO:0048813)3.18961121
71olfactory bulb development (GO:0021772)3.17983570
72limb bud formation (GO:0060174)3.17332186
73response to auditory stimulus (GO:0010996)3.15395623
74behavioral fear response (GO:0001662)3.13034895
75behavioral defense response (GO:0002209)3.13034895
76innervation (GO:0060384)3.11082849
77regulation of vesicle fusion (GO:0031338)3.08596796
78membrane hyperpolarization (GO:0060081)3.06933974
79neuromuscular process controlling balance (GO:0050885)3.06510916
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06055720
81regulation of neurotransmitter levels (GO:0001505)3.05113336
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.04867844
83positive regulation of synaptic transmission, GABAergic (GO:0032230)3.02702226
84regulation of neurotransmitter transport (GO:0051588)3.02395220
85synapse assembly (GO:0007416)3.02020352
86learning (GO:0007612)3.01967373
87regulation of dendritic spine development (GO:0060998)3.01940709
88positive regulation of dendritic spine development (GO:0060999)3.00471379
89central nervous system myelination (GO:0022010)2.99532928
90axon ensheathment in central nervous system (GO:0032291)2.99532928
91regulation of timing of cell differentiation (GO:0048505)2.98508562
92membrane depolarization (GO:0051899)2.97312250
93fear response (GO:0042596)2.95776090
94retinal cone cell development (GO:0046549)2.91699808
95positive regulation of synaptic transmission (GO:0050806)2.91399984
96cerebellar Purkinje cell differentiation (GO:0021702)2.90970660
97adult walking behavior (GO:0007628)2.90853597
98regulation of synaptic transmission (GO:0050804)2.90806224
99activation of protein kinase A activity (GO:0034199)2.90730524
100cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.90707069
101glial cell proliferation (GO:0014009)2.90060930
102regulation of voltage-gated calcium channel activity (GO:1901385)2.89059926
103vesicle transport along microtubule (GO:0047496)2.88825429
104neuronal ion channel clustering (GO:0045161)2.88609129
105positive regulation of neurotransmitter secretion (GO:0001956)2.88186640
106synaptic transmission (GO:0007268)2.87286348
107mechanosensory behavior (GO:0007638)2.87034573
108behavioral response to cocaine (GO:0048148)2.86323229
109negative regulation of neurotransmitter transport (GO:0051589)2.86154143
110dendritic spine organization (GO:0097061)2.85781842
111membrane depolarization during action potential (GO:0086010)2.85727857
112G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.85101467
113cerebellar granule cell differentiation (GO:0021707)2.84936634
114water-soluble vitamin biosynthetic process (GO:0042364)2.82995340
115intraciliary transport (GO:0042073)2.81215955
116protein localization to cilium (GO:0061512)2.78561999
117nonmotile primary cilium assembly (GO:0035058)2.74863551
118regulation of development, heterochronic (GO:0040034)2.72900202
119regulation of respiratory system process (GO:0044065)2.71026701
120righting reflex (GO:0060013)2.69526904
121central nervous system projection neuron axonogenesis (GO:0021952)2.68832135
122regulation of glucokinase activity (GO:0033131)2.68647137
123regulation of hexokinase activity (GO:1903299)2.68647137
124glycosphingolipid biosynthetic process (GO:0006688)2.66687915
125negative regulation of astrocyte differentiation (GO:0048712)2.65579428
126central nervous system neuron axonogenesis (GO:0021955)2.63187869
127cilium morphogenesis (GO:0060271)2.60531369
128neurotransmitter uptake (GO:0001504)2.58668236
129dentate gyrus development (GO:0021542)2.57395239
130negative regulation of cytosolic calcium ion concentration (GO:0051481)2.56409498
131inositol phosphate catabolic process (GO:0071545)2.54437460
132positive regulation of amino acid transport (GO:0051957)2.54004849
133retinal ganglion cell axon guidance (GO:0031290)2.53844647
134replication fork processing (GO:0031297)2.51327544
135regulation of neurotransmitter uptake (GO:0051580)2.50663437
136brain morphogenesis (GO:0048854)2.48451409
137lactate metabolic process (GO:0006089)2.47630505
138response to lipoprotein particle (GO:0055094)2.46335576
139oligodendrocyte differentiation (GO:0048709)2.40338263
140inner ear receptor stereocilium organization (GO:0060122)2.40065348
141detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.36191960
142neural tube formation (GO:0001841)2.34707896
143establishment of mitochondrion localization (GO:0051654)2.34081360
144regulation of cilium movement (GO:0003352)2.33829944
145cerebral cortex cell migration (GO:0021795)2.33414497
146cilium organization (GO:0044782)2.32604396
147negative regulation of transcription regulatory region DNA binding (GO:2000678)2.32433911
148protein K6-linked ubiquitination (GO:0085020)2.32075947
149cilium assembly (GO:0042384)2.31854140
150keratinocyte development (GO:0003334)2.29949791
151positive regulation of synapse assembly (GO:0051965)2.29002522
152negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.27731920
153regulation of collateral sprouting (GO:0048670)2.27227461
154L-fucose catabolic process (GO:0042355)2.25765264
155fucose catabolic process (GO:0019317)2.25765264
156L-fucose metabolic process (GO:0042354)2.25765264
157positive regulation of protein autophosphorylation (GO:0031954)2.24787657
158photoreceptor cell development (GO:0042461)2.22347073
159atrial cardiac muscle cell action potential (GO:0086014)2.21453327

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76710610
2GBX2_23144817_ChIP-Seq_PC3_Human3.72771659
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12950849
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05256605
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.04671597
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.96532589
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.66993083
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.66993083
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61148108
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.60483451
11REST_21632747_ChIP-Seq_MESCs_Mouse2.58267744
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.58190042
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.50912656
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.48923878
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47818809
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.45703456
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.35964756
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.35616441
19DROSHA_22980978_ChIP-Seq_HELA_Human2.32490521
20EWS_26573619_Chip-Seq_HEK293_Human2.21565686
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.21335488
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.19553388
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.19250785
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.06846747
25AR_21572438_ChIP-Seq_LNCaP_Human2.01922719
26TAF15_26573619_Chip-Seq_HEK293_Human1.87702687
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.86798900
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.85704810
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85623399
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84696831
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84087581
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80194467
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79287847
34NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.77324950
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.73639511
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68887196
37SMAD4_21799915_ChIP-Seq_A2780_Human1.67381985
38* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.65360677
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.55348969
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54708718
41P300_19829295_ChIP-Seq_ESCs_Human1.53127647
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52827848
43BCAT_22108803_ChIP-Seq_LS180_Human1.51411801
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47765229
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.45354295
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44987493
47EZH2_27294783_Chip-Seq_NPCs_Mouse1.43945339
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.43622085
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.43586246
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.41029677
51CBP_20019798_ChIP-Seq_JUKART_Human1.41029677
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40370429
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.40094097
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38830374
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38343083
56TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37849869
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37798709
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.37488120
59ERG_21242973_ChIP-ChIP_JURKAT_Human1.36651501
60* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35889549
61* P53_22387025_ChIP-Seq_ESCs_Mouse1.33435015
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31206162
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.30112677
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.29260016
65TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29106926
66AR_25329375_ChIP-Seq_VCAP_Human1.29048365
67RING1B_27294783_Chip-Seq_ESCs_Mouse1.28377747
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28052894
69TCF4_22108803_ChIP-Seq_LS180_Human1.27386601
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26608444
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26586810
72STAT3_23295773_ChIP-Seq_U87_Human1.26046899
73FLI1_21867929_ChIP-Seq_TH2_Mouse1.25763002
74IGF1R_20145208_ChIP-Seq_DFB_Human1.25279797
75RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24971858
76FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24786515
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23821321
78ZNF274_21170338_ChIP-Seq_K562_Hela1.23672911
79NFE2_27457419_Chip-Seq_LIVER_Mouse1.22798518
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.20554135
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.19190689
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.19141620
83FUS_26573619_Chip-Seq_HEK293_Human1.19086330
84HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18641301
85BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.18245956
86KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.17305036
87AR_19668381_ChIP-Seq_PC3_Human1.16321135
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15083490
89* CMYC_18555785_Chip-Seq_ESCs_Mouse1.14777309
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.13476918
91RING1B_27294783_Chip-Seq_NPCs_Mouse1.12856054
92TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.12787939
93* E2F1_18555785_Chip-Seq_ESCs_Mouse1.12736328
94RNF2_27304074_Chip-Seq_NSC_Mouse1.12364081
95P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12315838
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.12043151
97TCF4_23295773_ChIP-Seq_U87_Human1.11883604
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11077657
99RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10955148
100PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10786416
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.10210896
102* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10202667
103SOX9_26525672_Chip-Seq_HEART_Mouse1.09901929
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.08200466
105TAL1_26923725_Chip-Seq_HPCs_Mouse1.07824216
106PRDM14_20953172_ChIP-Seq_ESCs_Human1.07684521
107SOX2_19829295_ChIP-Seq_ESCs_Human1.07575775
108NANOG_19829295_ChIP-Seq_ESCs_Human1.07575775
109KDM2B_26808549_Chip-Seq_REH_Human1.06866201
110ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05510557
111NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04733101
112LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04633663
113VDR_22108803_ChIP-Seq_LS180_Human1.04609498
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04580671
115* P300_18555785_Chip-Seq_ESCs_Mouse1.04370543
116FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04138035
117YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04022237
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03885051
119CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02962424
120TP53_16413492_ChIP-PET_HCT116_Human1.02205592
121* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01971374
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.01854278
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01814109
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01800299
125RUNX2_22187159_ChIP-Seq_PCA_Human1.01335717
126VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01299148
127AHR_22903824_ChIP-Seq_MCF-7_Human1.01214612
128ER_23166858_ChIP-Seq_MCF-7_Human0.99825575
129DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99072299
130* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98835968
131TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97310484
132TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94542699
133JUN_21703547_ChIP-Seq_K562_Human0.92786350
134SMAD3_21741376_ChIP-Seq_ESCs_Human0.92597736
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91774273
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91774273
137WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90995610
138SMAD4_21741376_ChIP-Seq_HESCs_Human0.90586894
139* NANOG_18555785_Chip-Seq_ESCs_Mouse0.90439840
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89883031
141TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89262275
142SMAD3_21741376_ChIP-Seq_HESCs_Human0.88181963
143TP53_18474530_ChIP-ChIP_U2OS_Human0.87958336
144* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83267647

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03100018
2MP0003880_abnormal_central_pattern4.94765470
3MP0003635_abnormal_synaptic_transmissio3.97878504
4MP0004270_analgesia3.83688958
5MP0009745_abnormal_behavioral_response3.29301431
6MP0002063_abnormal_learning/memory/cond3.25850228
7MP0002064_seizures3.12516725
8MP0001968_abnormal_touch/_nociception2.87445371
9MP0009046_muscle_twitch2.86438190
10MP0005423_abnormal_somatic_nervous2.85928101
11MP0002572_abnormal_emotion/affect_behav2.75646766
12MP0001486_abnormal_startle_reflex2.74389786
13MP0002272_abnormal_nervous_system2.65756755
14MP0002734_abnormal_mechanical_nocicepti2.61050304
15MP0002822_catalepsy2.51446889
16MP0002736_abnormal_nociception_after2.27229972
17MP0002735_abnormal_chemical_nociception2.19385003
18MP0003329_amyloid_beta_deposits2.18711554
19MP0002102_abnormal_ear_morphology2.15714811
20MP0001501_abnormal_sleep_pattern2.14122207
21MP0000778_abnormal_nervous_system2.07359075
22MP0001440_abnormal_grooming_behavior2.06358593
23MP0002067_abnormal_sensory_capabilities1.96128611
24MP0002733_abnormal_thermal_nociception1.93154704
25MP0009780_abnormal_chondrocyte_physiolo1.91840147
26MP0001970_abnormal_pain_threshold1.91128588
27MP0000516_abnormal_urinary_system1.83592068
28MP0005367_renal/urinary_system_phenotyp1.83592068
29MP0008569_lethality_at_weaning1.82380005
30MP0008877_abnormal_DNA_methylation1.82157101
31MP0002184_abnormal_innervation1.80128598
32MP0005646_abnormal_pituitary_gland1.78490846
33MP0003121_genomic_imprinting1.76479224
34MP0001984_abnormal_olfaction1.72683311
35MP0004885_abnormal_endolymph1.72680322
36MP0004858_abnormal_nervous_system1.71374649
37MP0005248_abnormal_Harderian_gland1.70552482
38MP0002557_abnormal_social/conspecific_i1.69855301
39MP0004924_abnormal_behavior1.68262382
40MP0005386_behavior/neurological_phenoty1.68262382
41MP0005551_abnormal_eye_electrophysiolog1.67508845
42MP0006276_abnormal_autonomic_nervous1.64355287
43MP0004811_abnormal_neuron_physiology1.61928620
44MP0001529_abnormal_vocalization1.60120493
45MP0000955_abnormal_spinal_cord1.59939910
46MP0002882_abnormal_neuron_morphology1.54669332
47MP0008789_abnormal_olfactory_epithelium1.52197422
48MP0001502_abnormal_circadian_rhythm1.46753262
49MP0005645_abnormal_hypothalamus_physiol1.44831685
50MP0002066_abnormal_motor_capabilities/c1.42600401
51MP0001905_abnormal_dopamine_level1.42182536
52MP0000569_abnormal_digit_pigmentation1.41514439
53MP0003633_abnormal_nervous_system1.41354238
54MP0002751_abnormal_autonomic_nervous1.38163666
55MP0002234_abnormal_pharynx_morphology1.36638790
56MP0002909_abnormal_adrenal_gland1.35664793
57MP0004142_abnormal_muscle_tone1.34500005
58MP0003195_calcinosis1.31017509
59MP0002938_white_spotting1.30328578
60MP0003879_abnormal_hair_cell1.29014692
61MP0000920_abnormal_myelination1.28951825
62MP0003631_nervous_system_phenotype1.25544718
63MP0002229_neurodegeneration1.23364923
64MP0003787_abnormal_imprinting1.22745216
65MP0005187_abnormal_penis_morphology1.21911408
66MP0003011_delayed_dark_adaptation1.17288856
67MP0003690_abnormal_glial_cell1.16976482
68MP0003634_abnormal_glial_cell1.16967751
69MP0001188_hyperpigmentation1.15877094
70MP0002152_abnormal_brain_morphology1.15657585
71MP0004742_abnormal_vestibular_system1.13907668
72MP0000647_abnormal_sebaceous_gland1.09889756
73MP0008058_abnormal_DNA_repair1.05603630
74MP0002233_abnormal_nose_morphology1.04598641
75MP0000427_abnormal_hair_cycle1.03539139
76MP0002653_abnormal_ependyma_morphology1.02841643
77MP0003632_abnormal_nervous_system0.99798224
78MP0002090_abnormal_vision0.98829199
79MP0000604_amyloidosis0.98215321
80MP0002752_abnormal_somatic_nervous0.98007442
81MP0004147_increased_porphyrin_level0.97919923
82MP0003122_maternal_imprinting0.97554549
83MP0003755_abnormal_palate_morphology0.96837576
84MP0001963_abnormal_hearing_physiology0.94910519
85MP0004133_heterotaxia0.93775824
86MP0001177_atelectasis0.93512192
87MP0005394_taste/olfaction_phenotype0.93493484
88MP0005499_abnormal_olfactory_system0.93493484
89MP0000631_abnormal_neuroendocrine_gland0.91011728
90MP0002069_abnormal_eating/drinking_beha0.90627319
91MP0006072_abnormal_retinal_apoptosis0.89431884
92MP0001485_abnormal_pinna_reflex0.88854428
93MP0002928_abnormal_bile_duct0.87844474
94MP0005409_darkened_coat_color0.87715637
95MP0003937_abnormal_limbs/digits/tail_de0.87566714
96MP0005391_vision/eye_phenotype0.87478164
97MP0010234_abnormal_vibrissa_follicle0.86294792
98MP0000751_myopathy0.85627180
99MP0004145_abnormal_muscle_electrophysio0.85164685
100MP0001986_abnormal_taste_sensitivity0.84522047
101MP0002638_abnormal_pupillary_reflex0.83701053
102MP0005253_abnormal_eye_physiology0.83224903
103MP0000566_synostosis0.82498387
104MP0008872_abnormal_physiological_respon0.81607263
105MP0010386_abnormal_urinary_bladder0.81407120
106MP0000049_abnormal_middle_ear0.80593516
107MP0001293_anophthalmia0.79703671
108MP0004085_abnormal_heartbeat0.79134638
109MP0000013_abnormal_adipose_tissue0.77806583
110MP0003119_abnormal_digestive_system0.77524117
111MP0008874_decreased_physiological_sensi0.77265707
112MP0003075_altered_response_to0.74411223
113MP0005171_absent_coat_pigmentation0.73353836
114MP0005535_abnormal_body_temperature0.71997364
115MP0004043_abnormal_pH_regulation0.67986852
116MP0001664_abnormal_digestion0.66361741
117MP0003137_abnormal_impulse_conducting0.65952419
118MP0004215_abnormal_myocardial_fiber0.63762275
119MP0006292_abnormal_olfactory_placode0.63138620
120MP0005195_abnormal_posterior_eye0.63135195
121MP0000026_abnormal_inner_ear0.62949508
122MP0002837_dystrophic_cardiac_calcinosis0.61639903
123MP0001299_abnormal_eye_distance/0.61410734
124MP0003861_abnormal_nervous_system0.60289253
125MP0004233_abnormal_muscle_weight0.58103003
126MP0001943_abnormal_respiration0.56658500
127MP0004484_altered_response_of0.54401983
128MP0003283_abnormal_digestive_organ0.54011565
129MP0002876_abnormal_thyroid_physiology0.53843629
130MP0005623_abnormal_meninges_morphology0.50490918
131MP0010769_abnormal_survival0.50477055

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.26008544
2Myokymia (HP:0002411)6.26273392
3Focal seizures (HP:0007359)5.31050543
4Epileptic encephalopathy (HP:0200134)4.89242640
5Visual hallucinations (HP:0002367)4.55974779
6Atonic seizures (HP:0010819)4.23266691
7Febrile seizures (HP:0002373)4.08575469
8Progressive cerebellar ataxia (HP:0002073)4.00641490
9Absence seizures (HP:0002121)3.95584115
10Neurofibrillary tangles (HP:0002185)3.94814656
11Supranuclear gaze palsy (HP:0000605)3.94463087
12Dialeptic seizures (HP:0011146)3.72071115
13Action tremor (HP:0002345)3.71170289
14Generalized tonic-clonic seizures (HP:0002069)3.64748743
15Cerebral inclusion bodies (HP:0100314)3.59911916
16Hyperventilation (HP:0002883)3.49126667
17Broad-based gait (HP:0002136)3.41332196
18Ankle clonus (HP:0011448)3.38064533
19True hermaphroditism (HP:0010459)3.35273531
20Dysmetria (HP:0001310)3.17582826
21Dysdiadochokinesis (HP:0002075)3.16291096
22Pancreatic fibrosis (HP:0100732)3.15177851
23Abnormality of the labia minora (HP:0012880)3.11710310
24Truncal ataxia (HP:0002078)3.08765107
25Intestinal atresia (HP:0011100)3.07414152
26Impaired vibration sensation in the lower limbs (HP:0002166)3.02905062
27Medial flaring of the eyebrow (HP:0010747)3.02624783
28Gaze-evoked nystagmus (HP:0000640)3.02541928
29Abnormality of the corticospinal tract (HP:0002492)2.98720109
30Hemiparesis (HP:0001269)2.98301630
31Pancreatic cysts (HP:0001737)2.97105995
32Depression (HP:0000716)2.94594794
33Megalencephaly (HP:0001355)2.94583911
34Poor eye contact (HP:0000817)2.93052077
35Insidious onset (HP:0003587)2.91784194
36Termporal pattern (HP:0011008)2.91784194
37Urinary bladder sphincter dysfunction (HP:0002839)2.87969908
38Anxiety (HP:0000739)2.86586282
39Abnormality of midbrain morphology (HP:0002418)2.85060752
40Molar tooth sign on MRI (HP:0002419)2.85060752
41Excessive salivation (HP:0003781)2.78311338
42Drooling (HP:0002307)2.78311338
43Spastic gait (HP:0002064)2.78205546
44Abnormal eating behavior (HP:0100738)2.76170271
45Hypoglycemic seizures (HP:0002173)2.74214256
46Astrocytoma (HP:0009592)2.74038889
47Abnormality of the astrocytes (HP:0100707)2.74038889
48Mutism (HP:0002300)2.71203591
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.71044030
50Degeneration of the lateral corticospinal tracts (HP:0002314)2.71044030
51Nephronophthisis (HP:0000090)2.70573146
52Scanning speech (HP:0002168)2.70141555
53Amblyopia (HP:0000646)2.68394525
54Abnormal social behavior (HP:0012433)2.65093582
55Impaired social interactions (HP:0000735)2.65093582
56Congenital primary aphakia (HP:0007707)2.64680166
57Diplopia (HP:0000651)2.64481435
58Abnormality of binocular vision (HP:0011514)2.64481435
59Urinary urgency (HP:0000012)2.63224800
60Hyperinsulinemic hypoglycemia (HP:0000825)2.62797220
61Epileptiform EEG discharges (HP:0011182)2.62304718
62Postural instability (HP:0002172)2.61170157
63Intention tremor (HP:0002080)2.58433510
64Volvulus (HP:0002580)2.57019999
65EEG with generalized epileptiform discharges (HP:0011198)2.50096337
66Aqueductal stenosis (HP:0002410)2.46132620
67Genital tract atresia (HP:0001827)2.45645256
68Pheochromocytoma (HP:0002666)2.42828027
69Abnormality of the metopic suture (HP:0005556)2.42322824
70Neoplasm of the adrenal cortex (HP:0100641)2.42257285
71Nephrogenic diabetes insipidus (HP:0009806)2.42031713
72Progressive inability to walk (HP:0002505)2.39994999
73Hypoglycemic coma (HP:0001325)2.38244444
74Absent speech (HP:0001344)2.35616668
75Hypsarrhythmia (HP:0002521)2.34259244
76Lower limb muscle weakness (HP:0007340)2.33569218
77Hypothermia (HP:0002045)2.33210182
78Glioma (HP:0009733)2.30015925
79Ependymoma (HP:0002888)2.28820280
80Genetic anticipation (HP:0003743)2.27704987
81Abnormality of the renal medulla (HP:0100957)2.27471096
82Vaginal atresia (HP:0000148)2.27185845
83Colon cancer (HP:0003003)2.26905883
84Impaired smooth pursuit (HP:0007772)2.22979476
85Stereotypic behavior (HP:0000733)2.22818618
86Torticollis (HP:0000473)2.21831953
87Papilledema (HP:0001085)2.21826765
88Bradykinesia (HP:0002067)2.21549915
89Renal hypoplasia (HP:0000089)2.20676140
90Generalized myoclonic seizures (HP:0002123)2.19756828
91Methylmalonic acidemia (HP:0002912)2.17605229
92Retinal dysplasia (HP:0007973)2.16804757
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.16252147
94Polyphagia (HP:0002591)2.15997268
95Postaxial hand polydactyly (HP:0001162)2.14156997
96Neuroendocrine neoplasm (HP:0100634)2.09982942
97Chronic hepatic failure (HP:0100626)2.08620675
98Gait imbalance (HP:0002141)2.06984890
99Aplasia involving bones of the extremities (HP:0009825)2.06810121
100Aplasia involving bones of the upper limbs (HP:0009823)2.06810121
101Aplasia of the phalanges of the hand (HP:0009802)2.06810121
102Focal dystonia (HP:0004373)2.06450062
103Impaired vibratory sensation (HP:0002495)2.05889278
104Limb dystonia (HP:0002451)2.04586510
105Fetal akinesia sequence (HP:0001989)2.03640421
106Hemiplegia (HP:0002301)2.01524536
107Inability to walk (HP:0002540)1.99985492
108Peripheral hypomyelination (HP:0007182)1.98820849
109Thickened helices (HP:0000391)1.98447886
110Blue irides (HP:0000635)1.98257261
111Hepatoblastoma (HP:0002884)1.98100301
112Postaxial foot polydactyly (HP:0001830)1.96952128
113Clumsiness (HP:0002312)1.96660951
114Gastrointestinal atresia (HP:0002589)1.96600332
115Status epilepticus (HP:0002133)1.96312192
116Abnormality of ocular smooth pursuit (HP:0000617)1.95751182
117Neuronal loss in central nervous system (HP:0002529)1.95724215
118Abnormality of the renal cortex (HP:0011035)1.95567675
119Gait ataxia (HP:0002066)1.94178095
120Abnormality of the lower motor neuron (HP:0002366)1.93495775
121Progressive macrocephaly (HP:0004481)1.93469651
122Abnormality of salivation (HP:0100755)1.93230665
123Cystic liver disease (HP:0006706)1.92993888
124Delusions (HP:0000746)1.92708324
125Optic nerve hypoplasia (HP:0000609)1.92589747
126Hyperglycinemia (HP:0002154)1.90435671
127Oligodactyly (hands) (HP:0001180)1.89826081
128Central scotoma (HP:0000603)1.88733187
129Narrow forehead (HP:0000341)1.86148893
130Specific learning disability (HP:0001328)1.86027677
131Dyskinesia (HP:0100660)1.85756572
132Neoplasm of the oral cavity (HP:0100649)1.85533318
133Abolished electroretinogram (ERG) (HP:0000550)1.85488350
134Adrenal hypoplasia (HP:0000835)1.84249070
135Renal cortical cysts (HP:0000803)1.83536937
136Psychosis (HP:0000709)1.82262296
137Ketoacidosis (HP:0001993)1.81911888
138Craniofacial dystonia (HP:0012179)1.81570386
139Amyotrophic lateral sclerosis (HP:0007354)1.80155831
140Clonus (HP:0002169)1.79924810
141Poor coordination (HP:0002370)1.79315133
142Agitation (HP:0000713)1.78580439
143Congenital stationary night blindness (HP:0007642)1.78555089
144Incomplete penetrance (HP:0003829)1.77985215
145Prominent metopic ridge (HP:0005487)1.77942439
146Lissencephaly (HP:0001339)1.77461299
147Scrotal hypoplasia (HP:0000046)1.77011740
148Broad foot (HP:0001769)1.76825751
149Sclerocornea (HP:0000647)1.76564321
150Rigidity (HP:0002063)1.75952261
151Akinesia (HP:0002304)1.73620087
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.71689303
153Hypomagnesemia (HP:0002917)1.71458278
154Widely spaced teeth (HP:0000687)1.71337449
155Preaxial hand polydactyly (HP:0001177)1.71124674
156Abnormality of saccadic eye movements (HP:0000570)1.70636116
157Pachygyria (HP:0001302)1.69227092
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69165863
159Rapidly progressive (HP:0003678)1.68973368
160Abnormality of the pancreatic islet cells (HP:0006476)1.68678083
161Abnormality of endocrine pancreas physiology (HP:0012093)1.68678083
162Thyroiditis (HP:0100646)1.68321464
163Oligodactyly (HP:0012165)1.67668108
164Insomnia (HP:0100785)1.66550186
165Agnosia (HP:0010524)1.66507065
166Type II lissencephaly (HP:0007260)1.65405541
167Increased corneal curvature (HP:0100692)1.65356675
168Keratoconus (HP:0000563)1.65356675
169Occipital encephalocele (HP:0002085)1.65068415
170Epidermoid cyst (HP:0200040)1.65017587
171Male pseudohermaphroditism (HP:0000037)1.62903207
172Muscular hypotonia of the trunk (HP:0008936)1.61677981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.66958860
2FRK4.65056431
3NTRK34.22151363
4MARK13.26521719
5MAP3K93.22089287
6TRIM283.21590601
7MAP3K42.83375174
8MINK12.56251051
9MAP4K22.54491834
10MAP2K72.43623549
11CASK2.42780485
12BMPR1B2.36761376
13PAK62.24838581
14ERBB32.20007691
15DAPK22.12440144
16NTRK22.08850320
17KSR21.94212551
18NTRK11.88140693
19PRKD31.87684693
20RIPK41.76812699
21CCNB11.72683670
22PRPF4B1.69648292
23PNCK1.65817476
24NUAK11.63971961
25TNIK1.63382387
26MAP2K41.62563968
27MKNK21.62139693
28CDK51.56541673
29PLK21.53233867
30KSR11.51316830
31MAP3K121.46986730
32MAPK131.45127676
33ACVR1B1.44487510
34CSNK1G11.43497901
35CAMKK11.42625343
36CDK191.31934065
37GRK51.31111233
38MAP3K131.27691644
39OXSR11.27450235
40PHKG11.26995225
41PHKG21.26995225
42SGK4941.26798383
43SGK2231.26798383
44ARAF1.25980435
45CSNK1G31.25545997
46EIF2AK31.22137144
47UHMK11.21950241
48SIK31.21249927
49INSRR1.21247662
50DAPK11.20887412
51PLK31.19375047
52PRKCG1.16343405
53CSNK1A1L1.15233578
54CAMK2A1.14696672
55GRK11.11564722
56NEK11.11236589
57CAMK2B1.08427380
58FES1.08333236
59STK391.08256988
60SIK21.08225942
61MAP3K21.04854728
62DYRK21.02694386
63TYRO31.01809561
64WEE10.95924843
65MKNK10.94275556
66CDK140.92795234
67CDK180.92553129
68PAK30.91536216
69CDK150.91070535
70BMPR20.90881352
71STK380.89680119
72CAMKK20.87848297
73SGK20.87001762
74PTK2B0.86977534
75DYRK1A0.85657791
76MST40.85309743
77ADRBK20.82447659
78EPHA30.81574184
79CAMK10.80391773
80CDK11A0.78709616
81PINK10.77697959
82CSNK1G20.76938565
83FGR0.76658026
84LMTK20.76182759
85CAMK2D0.74026189
86PRKCH0.73361845
87RET0.72263937
88STK110.72159441
89SGK10.70824493
90NME10.70069632
91PRKCE0.68406734
92PKN10.67359290
93BUB10.66985773
94YES10.66602537
95MARK20.66521956
96SGK30.65963192
97STK38L0.64587134
98PLK40.63942370
99RAF10.63842133
100CAMK1G0.63687041
101FGFR20.63029853
102LATS20.60619019
103CAMK2G0.58806143
104NEK60.58328545
105MAPKAPK50.56111832
106ROCK10.56018218
107ROCK20.55921419
108BCR0.55850609
109PDPK10.54219160
110EPHB20.54195843
111ZAK0.53631899
112PDK10.53062077
113PRKCZ0.52970185
114CDK30.52242507
115AKT30.52045077
116WNK10.51609034
117NLK0.51404573
118PLK10.50684987
119CSNK1A10.50488461
120MUSK0.49896087
121BCKDK0.49059346
122TNK20.47813573
123FYN0.47381334
124RPS6KA30.46519069
125MAPK100.44484964
126MAP3K10.44027693
127FER0.43623524
128ATM0.42958231
129CSNK1D0.42069201
130WNK30.39251872
131BRSK20.38913540
132WNK40.38827790
133VRK10.37943373
134STK160.36873347
135MAP2K10.36742479
136IRAK20.36668023
137MAP3K70.36385880
138STK30.36215406
139TAOK10.35692322
140ADRBK10.35239849
141TSSK60.35097152
142TIE10.34779497
143PRKG10.34584307
144TGFBR10.34271353
145PRKDC0.33847549
146BRAF0.33770866
147MAPK120.33589262
148PRKACA0.32815431
149PRKACB0.30144983
150IRAK10.29399124
151CSNK1E0.29278732
152FGFR10.29059288

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.87450277
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09927013
3GABAergic synapse_Homo sapiens_hsa047272.85909419
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79489217
5Circadian entrainment_Homo sapiens_hsa047132.71104514
6Glutamatergic synapse_Homo sapiens_hsa047242.71094415
7Olfactory transduction_Homo sapiens_hsa047402.64659684
8Morphine addiction_Homo sapiens_hsa050322.59211492
9Long-term potentiation_Homo sapiens_hsa047202.55698562
10Protein export_Homo sapiens_hsa030602.36675400
11Amphetamine addiction_Homo sapiens_hsa050312.32279971
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.23648834
13Vitamin B6 metabolism_Homo sapiens_hsa007502.21710868
14Steroid biosynthesis_Homo sapiens_hsa001002.21132948
15Salivary secretion_Homo sapiens_hsa049702.16821994
16Dopaminergic synapse_Homo sapiens_hsa047282.13765936
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10922998
18Propanoate metabolism_Homo sapiens_hsa006402.03041509
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.94721046
20Insulin secretion_Homo sapiens_hsa049111.93958771
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91396016
22Cholinergic synapse_Homo sapiens_hsa047251.88288408
23Gastric acid secretion_Homo sapiens_hsa049711.83958023
24Serotonergic synapse_Homo sapiens_hsa047261.83003125
25Taste transduction_Homo sapiens_hsa047421.82557083
26Long-term depression_Homo sapiens_hsa047301.74148783
27Renin secretion_Homo sapiens_hsa049241.70991838
28Non-homologous end-joining_Homo sapiens_hsa034501.69547174
29Phototransduction_Homo sapiens_hsa047441.68004606
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.65640857
31Cocaine addiction_Homo sapiens_hsa050301.62632313
32Fanconi anemia pathway_Homo sapiens_hsa034601.61979012
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56249856
34Calcium signaling pathway_Homo sapiens_hsa040201.54901349
35Oxytocin signaling pathway_Homo sapiens_hsa049211.54745723
36Collecting duct acid secretion_Homo sapiens_hsa049661.50381628
37Nitrogen metabolism_Homo sapiens_hsa009101.47130655
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.41196203
39Basal transcription factors_Homo sapiens_hsa030221.35904665
40Fatty acid elongation_Homo sapiens_hsa000621.33037260
41Gap junction_Homo sapiens_hsa045401.31511081
42GnRH signaling pathway_Homo sapiens_hsa049121.31452557
43Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30784535
44Axon guidance_Homo sapiens_hsa043601.25498669
45Regulation of autophagy_Homo sapiens_hsa041401.24031074
46cAMP signaling pathway_Homo sapiens_hsa040241.22145409
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21282700
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.18483929
49Fatty acid metabolism_Homo sapiens_hsa012121.13546149
50Selenocompound metabolism_Homo sapiens_hsa004501.11599645
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11351616
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04820775
53Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04786030
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.04600325
55Peroxisome_Homo sapiens_hsa041461.00742377
56Glioma_Homo sapiens_hsa052140.99364620
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99083245
58Melanogenesis_Homo sapiens_hsa049160.98848040
59Cardiac muscle contraction_Homo sapiens_hsa042600.98440806
60Estrogen signaling pathway_Homo sapiens_hsa049150.98362969
61ErbB signaling pathway_Homo sapiens_hsa040120.98173257
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.96976501
63Vibrio cholerae infection_Homo sapiens_hsa051100.95460576
64Type II diabetes mellitus_Homo sapiens_hsa049300.94628797
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.93225842
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89360178
67Tryptophan metabolism_Homo sapiens_hsa003800.87817485
68Pancreatic secretion_Homo sapiens_hsa049720.84912352
69Dorso-ventral axis formation_Homo sapiens_hsa043200.83642853
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81576435
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.81271221
72Hedgehog signaling pathway_Homo sapiens_hsa043400.80463795
73beta-Alanine metabolism_Homo sapiens_hsa004100.79700282
74RNA degradation_Homo sapiens_hsa030180.76963284
75Homologous recombination_Homo sapiens_hsa034400.75350080
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72729255
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72356657
78Oocyte meiosis_Homo sapiens_hsa041140.70754477
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70071368
80Caffeine metabolism_Homo sapiens_hsa002320.69660502
81Choline metabolism in cancer_Homo sapiens_hsa052310.69461522
82Thyroid hormone synthesis_Homo sapiens_hsa049180.68867583
83Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68400713
84Primary bile acid biosynthesis_Homo sapiens_hsa001200.66936110
85Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66192543
86Fatty acid degradation_Homo sapiens_hsa000710.65436736
87Dilated cardiomyopathy_Homo sapiens_hsa054140.65230785
88MAPK signaling pathway_Homo sapiens_hsa040100.65124618
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64888446
90Hippo signaling pathway_Homo sapiens_hsa043900.64631554
91Ras signaling pathway_Homo sapiens_hsa040140.62590851
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61877029
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.59900244
94Lysine degradation_Homo sapiens_hsa003100.59025540
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.56156986
96Linoleic acid metabolism_Homo sapiens_hsa005910.55615110
97Alzheimers disease_Homo sapiens_hsa050100.53636843
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.53099570
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.53068573
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51647933
101Rap1 signaling pathway_Homo sapiens_hsa040150.50992449
102Alcoholism_Homo sapiens_hsa050340.50428413
103VEGF signaling pathway_Homo sapiens_hsa043700.50174510
104Renal cell carcinoma_Homo sapiens_hsa052110.49897745
105Circadian rhythm_Homo sapiens_hsa047100.48294040
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48184549
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.46145065
108Basal cell carcinoma_Homo sapiens_hsa052170.45559693
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45001433
110Inositol phosphate metabolism_Homo sapiens_hsa005620.44859579
111Cysteine and methionine metabolism_Homo sapiens_hsa002700.44793684
112Glucagon signaling pathway_Homo sapiens_hsa049220.44571548
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.44091506
114Endocytosis_Homo sapiens_hsa041440.43115885
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43016936
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42950394
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42771300
118Wnt signaling pathway_Homo sapiens_hsa043100.42466302
119Prion diseases_Homo sapiens_hsa050200.42259080
120Bile secretion_Homo sapiens_hsa049760.41227284
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40961224
122Fatty acid biosynthesis_Homo sapiens_hsa000610.40729902
123Retinol metabolism_Homo sapiens_hsa008300.40706748
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40423528
125African trypanosomiasis_Homo sapiens_hsa051430.39301482
126Mismatch repair_Homo sapiens_hsa034300.38919959
127Type I diabetes mellitus_Homo sapiens_hsa049400.38837587
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37310085
129Ether lipid metabolism_Homo sapiens_hsa005650.37184413
130ABC transporters_Homo sapiens_hsa020100.36506762
131Metabolic pathways_Homo sapiens_hsa011000.36105729
132Pyruvate metabolism_Homo sapiens_hsa006200.35919771
133Butanoate metabolism_Homo sapiens_hsa006500.35062519
134TGF-beta signaling pathway_Homo sapiens_hsa043500.35010368
135Ovarian steroidogenesis_Homo sapiens_hsa049130.34585252
136Oxidative phosphorylation_Homo sapiens_hsa001900.33743335
137Parkinsons disease_Homo sapiens_hsa050120.33561784
138Purine metabolism_Homo sapiens_hsa002300.33208796
139Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31186928
140Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30803060
141mTOR signaling pathway_Homo sapiens_hsa041500.30285872
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.29682015
143Endometrial cancer_Homo sapiens_hsa052130.29606528
144Mineral absorption_Homo sapiens_hsa049780.28142872

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