FAM172A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.15272536
2negative regulation of phagocytosis (GO:0050765)4.64492923
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.60347981
4presynaptic membrane assembly (GO:0097105)4.53386879
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44901893
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.44901893
7nucleobase catabolic process (GO:0046113)4.29251813
8epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.22273761
9mast cell activation (GO:0045576)4.13589828
10presynaptic membrane organization (GO:0097090)4.11089807
11DNA double-strand break processing (GO:0000729)4.10702267
12positive regulation of gamma-delta T cell activation (GO:0046645)4.10072661
13definitive hemopoiesis (GO:0060216)4.01334892
14intraciliary transport (GO:0042073)3.96821010
15neuron cell-cell adhesion (GO:0007158)3.81367041
16mast cell degranulation (GO:0043303)3.81352749
17mast cell activation involved in immune response (GO:0002279)3.81352749
18platelet dense granule organization (GO:0060155)3.77394076
19antigen processing and presentation of endogenous antigen (GO:0019883)3.74630876
20regulation of B cell receptor signaling pathway (GO:0050855)3.69248121
21epithelial cilium movement (GO:0003351)3.67016531
22megakaryocyte development (GO:0035855)3.64230878
23protein localization to cilium (GO:0061512)3.62143707
24cilium morphogenesis (GO:0060271)3.57854303
25limb bud formation (GO:0060174)3.55651527
26axoneme assembly (GO:0035082)3.48508304
27leukocyte aggregation (GO:0070486)3.44958025
28gamma-aminobutyric acid transport (GO:0015812)3.44925035
29Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43936981
30positive regulation of B cell differentiation (GO:0045579)3.42186759
31postsynaptic membrane organization (GO:0001941)3.35530595
32negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.32221814
33cilium movement (GO:0003341)3.28495048
34positive regulation of granulocyte differentiation (GO:0030854)3.24507602
35cilium or flagellum-dependent cell motility (GO:0001539)3.22322586
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.16248258
37regulation of B cell differentiation (GO:0045577)3.16052359
38B cell receptor signaling pathway (GO:0050853)3.14278582
39lymphoid progenitor cell differentiation (GO:0002320)3.12746071
40protein prenylation (GO:0018342)3.11304016
41prenylation (GO:0097354)3.11304016
42nonmotile primary cilium assembly (GO:0035058)3.08611359
43secretory granule organization (GO:0033363)3.06084890
44olfactory bulb development (GO:0021772)3.05460280
45T cell homeostasis (GO:0043029)3.05133974
46T cell migration (GO:0072678)3.05107138
47myeloid dendritic cell activation (GO:0001773)3.04799413
48DNA integration (GO:0015074)3.03414914
49cilium organization (GO:0044782)3.01953794
50cilium assembly (GO:0042384)3.01178109
51retinal ganglion cell axon guidance (GO:0031290)2.98191645
52regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.97830623
53interferon-gamma production (GO:0032609)2.95564341
54establishment of protein localization to Golgi (GO:0072600)2.94545797
55alternative mRNA splicing, via spliceosome (GO:0000380)2.94448957
56central nervous system projection neuron axonogenesis (GO:0021952)2.93023007
57regulation of cilium movement (GO:0003352)2.93016555
58necroptotic process (GO:0070266)2.92850670
59phagocytosis, engulfment (GO:0006911)2.88437581
60negative T cell selection (GO:0043383)2.88303494
61startle response (GO:0001964)2.87681157
62protein targeting to Golgi (GO:0000042)2.87480775
63glycosphingolipid biosynthetic process (GO:0006688)2.86536230
64regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.86353506
65dendritic spine morphogenesis (GO:0060997)2.83071071
66endosome to pigment granule transport (GO:0043485)2.81964056
67endosome to melanosome transport (GO:0035646)2.81964056
68negative thymic T cell selection (GO:0045060)2.81806717
69regulation of timing of cell differentiation (GO:0048505)2.81141896
70glucocorticoid receptor signaling pathway (GO:0042921)2.80991821
71regulation of development, heterochronic (GO:0040034)2.80353028
72barbed-end actin filament capping (GO:0051016)2.79141919
73central nervous system neuron axonogenesis (GO:0021955)2.78366422
74neural tube formation (GO:0001841)2.77372125
75B cell homeostasis (GO:0001782)2.77094973
76positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.75378324
77fucose catabolic process (GO:0019317)2.74904480
78L-fucose metabolic process (GO:0042354)2.74904480
79L-fucose catabolic process (GO:0042355)2.74904480
80telomere maintenance via recombination (GO:0000722)2.73588739
81positive regulation of amino acid transport (GO:0051957)2.73027503
82regulation of neurotransmitter uptake (GO:0051580)2.72126136
83retrograde transport, vesicle recycling within Golgi (GO:0000301)2.70971606
84telomere maintenance via semi-conservative replication (GO:0032201)2.70813727
85neuron fate determination (GO:0048664)2.70223060
86fatty acid elongation (GO:0030497)2.70025462
87protein polyglutamylation (GO:0018095)2.69585841
88regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68980114
89DNA topological change (GO:0006265)2.68873026
90translesion synthesis (GO:0019985)2.68232550
91negative regulation of oligodendrocyte differentiation (GO:0048715)2.68092471
92DNA strand elongation involved in DNA replication (GO:0006271)2.67794804
93axonal fasciculation (GO:0007413)2.67418564
94actin nucleation (GO:0045010)2.67205231
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.66729233
96mitotic recombination (GO:0006312)2.66372188
97regulation of gamma-delta T cell differentiation (GO:0045586)2.66182326
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.65047568
99respiratory burst (GO:0045730)2.64565696
100proline transport (GO:0015824)2.64220420
101membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.63095892
102positive regulation of histone H3-K4 methylation (GO:0051571)2.62981956
103defense response to protozoan (GO:0042832)2.62887125
104response to protozoan (GO:0001562)2.62771587
105positive regulation of synapse assembly (GO:0051965)2.62331758
106DNA deamination (GO:0045006)2.62266189
107response to pheromone (GO:0019236)2.62028088
108positive regulation of lamellipodium assembly (GO:0010592)2.61912392
109negative regulation of erythrocyte differentiation (GO:0045647)2.61792488
110negative regulation of cell killing (GO:0031342)2.61414892
111negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.61414892
112cartilage morphogenesis (GO:0060536)2.61323260
113water-soluble vitamin biosynthetic process (GO:0042364)2.60790542
114regulation of erythrocyte differentiation (GO:0045646)2.59818352
115leukocyte degranulation (GO:0043299)2.59668805
116vocalization behavior (GO:0071625)2.59270437
117sequestering of actin monomers (GO:0042989)2.58720374
118axonemal dynein complex assembly (GO:0070286)2.58176152
119behavioral response to nicotine (GO:0035095)2.57979930
120lymphocyte homeostasis (GO:0002260)2.57698774
121leukocyte homeostasis (GO:0001776)2.57693179
122DNA strand elongation (GO:0022616)2.57442029
123positive regulation of meiosis (GO:0045836)2.56175352
124calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.55677937
125dentate gyrus development (GO:0021542)2.55275795
126embryonic hemopoiesis (GO:0035162)2.55136885
127fucosylation (GO:0036065)2.54970922
128behavioral defense response (GO:0002209)2.53991257
129behavioral fear response (GO:0001662)2.53991257
130synapse assembly (GO:0007416)2.53953551
131signal peptide processing (GO:0006465)2.53574555
132neuron recognition (GO:0008038)2.53064571
133smoothened signaling pathway (GO:0007224)2.52298927
134ribosomal small subunit assembly (GO:0000028)2.51948157
135retinal cone cell development (GO:0046549)2.51943630
136positive regulation of glycolytic process (GO:0045821)2.51701572
137viral mRNA export from host cell nucleus (GO:0046784)2.51551573
138aggressive behavior (GO:0002118)2.51357909
139regulation of synapse assembly (GO:0051963)2.51298758
140negative regulation of synaptic transmission, GABAergic (GO:0032229)2.50283026
141regulation of oligodendrocyte differentiation (GO:0048713)2.49907925
142neutrophil activation involved in immune response (GO:0002283)2.49544483
143V(D)J recombination (GO:0033151)2.49330108
144cellular component assembly involved in morphogenesis (GO:0010927)2.48468732
145negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48442522
146positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.48333925
147myeloid cell activation involved in immune response (GO:0002275)2.47837642
148anterograde synaptic vesicle transport (GO:0048490)2.46508827
149regulation of T cell receptor signaling pathway (GO:0050856)2.46028903
150lysosome localization (GO:0032418)2.45963524
151deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45286141
152cerebral cortex radially oriented cell migration (GO:0021799)2.44091349
153regulation of gamma-delta T cell activation (GO:0046643)2.43633596
154auditory behavior (GO:0031223)2.42357417
155glutamate receptor signaling pathway (GO:0007215)2.42013287
156antigen receptor-mediated signaling pathway (GO:0050851)2.42012085
157antigen processing and presentation via MHC class Ib (GO:0002475)2.41856319
158glial cell proliferation (GO:0014009)2.41852313
159positive regulation of oligodendrocyte differentiation (GO:0048714)2.41805702
160DNA unwinding involved in DNA replication (GO:0006268)2.41451552
161positive regulation of macrophage differentiation (GO:0045651)2.40691736
162positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.40689379
163regulation of sarcomere organization (GO:0060297)2.39182105
164positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.39139592
165membrane invagination (GO:0010324)2.39070273
166reflex (GO:0060004)2.38485563
167ionotropic glutamate receptor signaling pathway (GO:0035235)2.38048377
168fear response (GO:0042596)2.37678148
169prostate gland growth (GO:0060736)2.37167082
170protein localization to Golgi apparatus (GO:0034067)2.36381667
171vascular smooth muscle contraction (GO:0014829)2.35723442
172positive regulation of lamellipodium organization (GO:1902745)2.35344255
173behavioral response to ethanol (GO:0048149)2.35266771
174protein neddylation (GO:0045116)2.34887395
175transmission of nerve impulse (GO:0019226)2.34454656
176negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34361094
177inner ear receptor stereocilium organization (GO:0060122)2.33848115
178regulation of respiratory system process (GO:0044065)2.33523316
179cornea development in camera-type eye (GO:0061303)2.33210367
180histone H2A acetylation (GO:0043968)2.33109973
181histamine secretion (GO:0001821)2.32724857
182microtubule nucleation (GO:0007020)2.32485424
183myeloid dendritic cell differentiation (GO:0043011)2.32427238
184regulation of necroptotic process (GO:0060544)2.32327851
185detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.31850107
186negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.31533002
187hindbrain development (GO:0030902)2.31395239
188cellular response to interleukin-15 (GO:0071350)2.29960336
189regulation of MHC class II biosynthetic process (GO:0045346)2.29871558
190response to interleukin-15 (GO:0070672)2.27358553
191corticosteroid receptor signaling pathway (GO:0031958)2.25677658
192negative regulation of B cell proliferation (GO:0030889)2.25621116
193tolerance induction (GO:0002507)2.23720330
194myeloid cell development (GO:0061515)2.20294542
195negative regulation of immunoglobulin mediated immune response (GO:0002890)2.19405355
196negative regulation of B cell mediated immunity (GO:0002713)2.19405355
197neutrophil mediated immunity (GO:0002446)2.19319289
198necrotic cell death (GO:0070265)2.19253997
199DNA synthesis involved in DNA repair (GO:0000731)2.19119416
200regulation of interleukin-12 biosynthetic process (GO:0045075)2.18874302

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.93175690
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.34833077
3SCL_19346495_ChIP-Seq_HPC-7_Human4.13002944
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.57530668
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.52126738
6GBX2_23144817_ChIP-Seq_PC3_Human3.36931488
7* ZFP57_27257070_Chip-Seq_ESCs_Mouse3.15399181
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.11042439
9TAF15_26573619_Chip-Seq_HEK293_Human2.90034246
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86967020
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.79588774
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.74868753
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.66970947
14ZNF274_21170338_ChIP-Seq_K562_Hela2.62345147
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61165998
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53178506
17FUS_26573619_Chip-Seq_HEK293_Human2.51345144
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.45872609
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.42038862
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.36334448
21MYC_22102868_ChIP-Seq_BL_Human2.36158703
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.35481004
23IRF8_21731497_ChIP-ChIP_J774_Mouse2.33894523
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.26106808
25RUNX_20019798_ChIP-Seq_JUKART_Human2.24344972
26MYB_26560356_Chip-Seq_TH2_Human2.23381462
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.22876757
28P300_19829295_ChIP-Seq_ESCs_Human2.22864310
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.21729184
30FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.19096696
31SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15922706
32HOXB4_20404135_ChIP-ChIP_EML_Mouse2.12308048
33SPI1_23547873_ChIP-Seq_NB4_Human2.10981254
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08893168
35FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.03269091
36SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.03121377
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse2.00332110
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98063199
39TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.96394275
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.96062905
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.95192171
42VDR_21846776_ChIP-Seq_THP-1_Human1.94299088
43* SMAD4_21799915_ChIP-Seq_A2780_Human1.94194593
44SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.93806094
45* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.91774974
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91361019
47* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91359516
48PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.90470279
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.89410761
50OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.87263808
51IRF8_27001747_Chip-Seq_BMDM_Mouse1.86746861
52CIITA_25753668_ChIP-Seq_RAJI_Human1.86281764
53GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.83472159
54EZH2_22144423_ChIP-Seq_EOC_Human1.81459144
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.79884987
56PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79876084
57VDR_22108803_ChIP-Seq_LS180_Human1.79738481
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.79089790
59GATA1_22025678_ChIP-Seq_K562_Human1.79036512
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.78291167
61VDR_24763502_ChIP-Seq_THP-1_Human1.77815564
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.76770008
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.76730717
64MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.75371345
65* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74708437
66ER_23166858_ChIP-Seq_MCF-7_Human1.73565855
67FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70710600
68SPI1_23127762_ChIP-Seq_K562_Human1.66611802
69BCAT_22108803_ChIP-Seq_LS180_Human1.65843109
70MYB_26560356_Chip-Seq_TH1_Human1.63213132
71UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63115980
72IGF1R_20145208_ChIP-Seq_DFB_Human1.62197442
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.61793985
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.59758287
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.58303842
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57557500
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.56680339
78AR_25329375_ChIP-Seq_VCAP_Human1.56520128
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55925420
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.55251474
81NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.55144117
82TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53445317
83TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51973575
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51893909
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.51891542
86STAT3_23295773_ChIP-Seq_U87_Human1.51155749
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.50304385
88MAF_26560356_Chip-Seq_TH1_Human1.50263358
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.45182885
90CBP_20019798_ChIP-Seq_JUKART_Human1.44686193
91IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44686193
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.42287317
93UTX_26944678_Chip-Seq_JUKART_Human1.41405053
94TCF7_22412390_ChIP-Seq_EML_Mouse1.41021197
95MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40612288
96PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39829925
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.39429988
98GATA3_27048872_Chip-Seq_THYMUS_Human1.38466699
99SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36574908
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34612366
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.34515992
102FOXP3_21729870_ChIP-Seq_TREG_Human1.34154670
103DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.33885118
104* RNF2_27304074_Chip-Seq_NSC_Mouse1.32794738
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.32729820
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.32507837
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32395578
108* TCF4_23295773_ChIP-Seq_U87_Human1.32124046
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31558164
110* FLI1_21867929_ChIP-Seq_TH2_Mouse1.30927960
111P53_22387025_ChIP-Seq_ESCs_Mouse1.30869557
112VDR_23849224_ChIP-Seq_CD4+_Human1.30706780
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30240139
114TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.29943442
115PU_27001747_Chip-Seq_BMDM_Mouse1.29853289
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28534448
117NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.26799740
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.26292098
119ELK1_19687146_ChIP-ChIP_HELA_Human1.26171071
120TCF4_22108803_ChIP-Seq_LS180_Human1.25875810
121NOTCH1_21737748_ChIP-Seq_TLL_Human1.25196619
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24604702
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24265656
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23666739
125TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23666739
126NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23643917
127NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23643917
128E2F1_18555785_Chip-Seq_ESCs_Mouse1.22475850
129RUNX2_22187159_ChIP-Seq_PCA_Human1.22227354
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21196014
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.20704682
132BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18112765
133* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.17239113
134FOXM1_23109430_ChIP-Seq_U2OS_Human1.15872196
135AR_21572438_ChIP-Seq_LNCaP_Human1.15811688
136RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15480236
137* TAL1_26923725_Chip-Seq_HPCs_Mouse1.15269278
138SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14342475
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.13701903
140NANOG_19829295_ChIP-Seq_ESCs_Human1.13561521
141SOX2_19829295_ChIP-Seq_ESCs_Human1.13561521
142SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13454284
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13392825
144JUN_21703547_ChIP-Seq_K562_Human1.13056884
145TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12931918
146BP1_19119308_ChIP-ChIP_Hs578T_Human1.12705062
147KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12505996
148CMYC_18555785_Chip-Seq_ESCs_Mouse1.12374378
149THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09664863
150P300_18555785_Chip-Seq_ESCs_Mouse1.09160246
151EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.09132035
152* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08495499
153FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08474906
154OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07844147
155E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.07611481
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.07425020
157KDM2B_26808549_Chip-Seq_REH_Human1.07325922
158NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.07055575
159EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06879709
160KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06647840
161STAT3_18555785_Chip-Seq_ESCs_Mouse1.05302355
162REST_21632747_ChIP-Seq_MESCs_Mouse1.05224963
163LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04245134
164* PRDM14_20953172_ChIP-Seq_ESCs_Human1.03881425
165CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.03266403
166SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.02956840
167GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02864742
168IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.99488694
169GATA3_26560356_Chip-Seq_TH2_Human0.98595778
170PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98580666
171EWS_26573619_Chip-Seq_HEK293_Human0.96082384
172E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95024786
173ETS1_22383799_ChIP-Seq_G1ME_Mouse0.94894095
174SRF_21415370_ChIP-Seq_HL-1_Mouse0.94027961
175KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93430362
176GATA1_19941827_ChIP-Seq_MEL_Mouse0.92048978
177GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91459494
178POU3F2_20337985_ChIP-ChIP_501MEL_Human0.90936314
179* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86880379
180* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86112181
181TFEB_21752829_ChIP-Seq_HELA_Human0.85998313
182RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85500783
183ZFX_18555785_ChIP-Seq_MESCs_Mouse0.82474526
184FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81265251
185SMAD_19615063_ChIP-ChIP_OVARY_Human0.77913843
186GABP_17652178_ChIP-ChIP_JURKAT_Human0.76435417
187LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76341530
188MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.74461888
189NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.73930897
190KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73538525
191XRN2_22483619_ChIP-Seq_HELA_Human0.73365150

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.10107087
2MP0002396_abnormal_hematopoietic_system3.45969334
3MP0001835_abnormal_antigen_presentation3.12277113
4MP0003183_abnormal_peptide_metabolism3.02074185
5MP0003880_abnormal_central_pattern2.99978267
6MP0005174_abnormal_tail_pigmentation2.90923025
7MP0003763_abnormal_thymus_physiology2.88056393
8MP0005671_abnormal_response_to2.81198544
9MP0008877_abnormal_DNA_methylation2.53148908
10MP0000465_gastrointestinal_hemorrhage2.48640458
11MP0002166_altered_tumor_susceptibility2.46435894
12MP0002398_abnormal_bone_marrow2.27547927
13MP0006072_abnormal_retinal_apoptosis2.26572327
14MP0000015_abnormal_ear_pigmentation2.25568744
15MP0005253_abnormal_eye_physiology2.22780817
16MP0002420_abnormal_adaptive_immunity2.17160920
17MP0005464_abnormal_platelet_physiology2.16818101
18MP0000778_abnormal_nervous_system2.14914907
19MP0001819_abnormal_immune_cell2.13742272
20MP0002452_abnormal_antigen_presenting2.04902382
21MP0005000_abnormal_immune_tolerance2.04185702
22MP0002095_abnormal_skin_pigmentation2.03602923
23MP0002006_tumorigenesis2.00173831
24MP0005187_abnormal_penis_morphology1.99244803
25MP0006054_spinal_hemorrhage1.98933587
26MP0001800_abnormal_humoral_immune1.96475396
27MP0002419_abnormal_innate_immunity1.95163784
28MP0006276_abnormal_autonomic_nervous1.94573614
29MP0001486_abnormal_startle_reflex1.94457957
30MP0000685_abnormal_immune_system1.93991954
31MP0005248_abnormal_Harderian_gland1.92709538
32MP0005551_abnormal_eye_electrophysiolog1.90666882
33MP0002723_abnormal_immune_serum1.89885528
34MP0001545_abnormal_hematopoietic_system1.86913480
35MP0005397_hematopoietic_system_phenotyp1.86913480
36MP0000716_abnormal_immune_system1.86180485
37MP0004808_abnormal_hematopoietic_stem1.85691902
38MP0005646_abnormal_pituitary_gland1.82159637
39MP0002638_abnormal_pupillary_reflex1.81705253
40MP0003172_abnormal_lysosome_physiology1.81619377
41MP0003121_genomic_imprinting1.79063895
42MP0002272_abnormal_nervous_system1.77732923
43MP0005645_abnormal_hypothalamus_physiol1.75374437
44MP0003122_maternal_imprinting1.74693177
45MP0008057_abnormal_DNA_replication1.70266907
46MP0009745_abnormal_behavioral_response1.68853782
47MP0000689_abnormal_spleen_morphology1.68031012
48MP0010094_abnormal_chromosome_stability1.67763667
49MP0009785_altered_susceptibility_to1.67186262
50MP0005025_abnormal_response_to1.65701630
51MP0000703_abnormal_thymus_morphology1.64021180
52MP0000516_abnormal_urinary_system1.63356632
53MP0005367_renal/urinary_system_phenotyp1.63356632
54MP0002429_abnormal_blood_cell1.62520849
55MP0009046_muscle_twitch1.62448451
56MP0002722_abnormal_immune_system1.60762186
57MP0001968_abnormal_touch/_nociception1.60325722
58MP0003635_abnormal_synaptic_transmissio1.60156025
59MP0005084_abnormal_gallbladder_morpholo1.59571917
60MP0002148_abnormal_hypersensitivity_rea1.59205295
61MP0005075_abnormal_melanosome_morpholog1.59086200
62MP0002837_dystrophic_cardiac_calcinosis1.58635553
63MP0003943_abnormal_hepatobiliary_system1.58580235
64MP0003303_peritoneal_inflammation1.56767485
65MP0002736_abnormal_nociception_after1.55147925
66MP0002234_abnormal_pharynx_morphology1.54465892
67MP0002282_abnormal_trachea_morphology1.54407507
68MP0004270_analgesia1.54174953
69MP0008007_abnormal_cellular_replicative1.52144283
70MP0002572_abnormal_emotion/affect_behav1.51348477
71MP0008789_abnormal_olfactory_epithelium1.51123793
72MP0004142_abnormal_muscle_tone1.47665482
73MP0005387_immune_system_phenotype1.45066945
74MP0001790_abnormal_immune_system1.45066945
75MP0002751_abnormal_autonomic_nervous1.44984994
76MP0009333_abnormal_splenocyte_physiolog1.43602336
77MP0002009_preneoplasia1.42479852
78MP0000427_abnormal_hair_cycle1.41518304
79MP0002909_abnormal_adrenal_gland1.40172888
80MP0004859_abnormal_synaptic_plasticity1.38866403
81MP0002557_abnormal_social/conspecific_i1.38512463
82MP0002822_catalepsy1.37496701
83MP0003436_decreased_susceptibility_to1.36931645
84MP0000490_abnormal_crypts_of1.35622270
85MP0005423_abnormal_somatic_nervous1.34671299
86MP0002405_respiratory_system_inflammati1.34432886
87MP0002064_seizures1.32879214
88MP0004133_heterotaxia1.31517298
89MP0002734_abnormal_mechanical_nocicepti1.29916615
90MP0004134_abnormal_chest_morphology1.29746751
91MP0004215_abnormal_myocardial_fiber1.27501881
92MP0002090_abnormal_vision1.26825574
93MP0004885_abnormal_endolymph1.26813475
94MP0002735_abnormal_chemical_nociception1.26495268
95MP0003724_increased_susceptibility_to1.25748466
96MP0005386_behavior/neurological_phenoty1.24813016
97MP0004924_abnormal_behavior1.24813016
98MP0003195_calcinosis1.22642217
99MP0001299_abnormal_eye_distance/1.22020718
100MP0002102_abnormal_ear_morphology1.21680264
101MP0001485_abnormal_pinna_reflex1.20864869
102MP0005409_darkened_coat_color1.19313539
103MP0001986_abnormal_taste_sensitivity1.18288424
104MP0010386_abnormal_urinary_bladder1.17062275
105MP0001177_atelectasis1.16835181
106MP0005058_abnormal_lysosome_morphology1.16625826
107MP0000647_abnormal_sebaceous_gland1.16475852
108MP0002067_abnormal_sensory_capabilities1.16390584
109MP0003866_abnormal_defecation1.15573800
110MP0002928_abnormal_bile_duct1.14541786
111MP0001501_abnormal_sleep_pattern1.13241585
112MP0005195_abnormal_posterior_eye1.12287187
113MP0006292_abnormal_olfactory_placode1.11634408
114MP0003937_abnormal_limbs/digits/tail_de1.11522731
115MP0005391_vision/eye_phenotype1.11453883
116MP0000920_abnormal_myelination1.10252196
117MP0003300_gastrointestinal_ulcer1.09179201
118MP0001970_abnormal_pain_threshold1.08651957
119MP0000955_abnormal_spinal_cord1.08210285
120MP0005379_endocrine/exocrine_gland_phen1.07761564
121MP0010155_abnormal_intestine_physiology1.06840905
122MP0001853_heart_inflammation1.05636076
123MP0003755_abnormal_palate_morphology1.05216437
124MP0002295_abnormal_pulmonary_circulatio1.03140395
125MP0005171_absent_coat_pigmentation1.02889335
126MP0003890_abnormal_embryonic-extraembry1.02769863
127MP0002233_abnormal_nose_morphology1.02719474
128MP0001873_stomach_inflammation1.02714126
129MP0001984_abnormal_olfaction1.02021332
130MP0002877_abnormal_melanocyte_morpholog1.01901915
131MP0005499_abnormal_olfactory_system1.01824440
132MP0005394_taste/olfaction_phenotype1.01824440
133MP0002184_abnormal_innervation1.00731536
134MP0005310_abnormal_salivary_gland1.00674803
135MP0002752_abnormal_somatic_nervous0.99369028
136MP0003656_abnormal_erythrocyte_physiolo0.98928302
137MP0002089_abnormal_postnatal_growth/wei0.98531565
138MP0008058_abnormal_DNA_repair0.98462209
139MP0003077_abnormal_cell_cycle0.98213468
140MP0008569_lethality_at_weaning0.97415250
141MP0003136_yellow_coat_color0.96996235
142MP0003633_abnormal_nervous_system0.96821524
143MP0002882_abnormal_neuron_morphology0.96182978
144MP0003011_delayed_dark_adaptation0.94860548
145MP0001440_abnormal_grooming_behavior0.92090503
146MP0000049_abnormal_middle_ear0.91717947
147MP0001845_abnormal_inflammatory_respons0.89799470
148MP0002733_abnormal_thermal_nociception0.89227803
149MP0004147_increased_porphyrin_level0.88030244
150MP0000383_abnormal_hair_follicle0.86887653
151MP0002019_abnormal_tumor_incidence0.85884938
152MP0000631_abnormal_neuroendocrine_gland0.85338168
153MP0000013_abnormal_adipose_tissue0.85191746
154MP0002933_joint_inflammation0.84793274
155MP0010678_abnormal_skin_adnexa0.84700216
156MP0002876_abnormal_thyroid_physiology0.84414514
157MP0001533_abnormal_skeleton_physiology0.83989849
158MP0002152_abnormal_brain_morphology0.82621393
159MP0002938_white_spotting0.82153645
160MP0001502_abnormal_circadian_rhythm0.81579007
161MP0003787_abnormal_imprinting0.80793140
162MP0000681_abnormal_thyroid_gland0.78213492
163MP0002075_abnormal_coat/hair_pigmentati0.76379223
164MP0002163_abnormal_gland_morphology0.76036372
165MP0006082_CNS_inflammation0.75055827
166MP0009697_abnormal_copulation0.74330937
167MP0002063_abnormal_learning/memory/cond0.74242671
168MP0003075_altered_response_to0.71223164
169MP0001188_hyperpigmentation0.71016508
170MP0000858_altered_metastatic_potential0.70718574
171MP0010307_abnormal_tumor_latency0.70242916
172MP0004811_abnormal_neuron_physiology0.68849731
173MP0000372_irregular_coat_pigmentation0.67961604
174MP0009780_abnormal_chondrocyte_physiolo0.64253760
175MP0001905_abnormal_dopamine_level0.63829946
176MP0003567_abnormal_fetal_cardiomyocyte0.61235222
177MP0001186_pigmentation_phenotype0.61136288
178MP0001529_abnormal_vocalization0.60931599
179MP0000313_abnormal_cell_death0.60375748
180MP0002998_abnormal_bone_remodeling0.59157123
181MP0003690_abnormal_glial_cell0.58753078

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.51810609
2Papilledema (HP:0001085)4.00658789
3Pancreatic fibrosis (HP:0100732)3.83218124
4True hermaphroditism (HP:0010459)3.82506246
5Intestinal atresia (HP:0011100)3.65493891
6Pancreatic cysts (HP:0001737)3.64565891
7Thrombocytosis (HP:0001894)3.55755654
8IgM deficiency (HP:0002850)3.46830253
9Hyperventilation (HP:0002883)3.46583150
10Medial flaring of the eyebrow (HP:0010747)3.41128201
11Recurrent viral infections (HP:0004429)3.39684842
12Gait imbalance (HP:0002141)3.38937987
13Myositis (HP:0100614)3.25791683
14Congenital primary aphakia (HP:0007707)3.22361335
15Nephrogenic diabetes insipidus (HP:0009806)3.20012953
16Recurrent abscess formation (HP:0002722)3.17884709
17Aplastic anemia (HP:0001915)3.08820711
18Abnormality of midbrain morphology (HP:0002418)3.05283713
19Molar tooth sign on MRI (HP:0002419)3.05283713
20Genital tract atresia (HP:0001827)2.93897410
21Nephronophthisis (HP:0000090)2.91557779
22Drooling (HP:0002307)2.88947499
23Hypothermia (HP:0002045)2.88211058
24Elevated erythrocyte sedimentation rate (HP:0003565)2.88207981
25Recurrent bronchitis (HP:0002837)2.87427494
26Panhypogammaglobulinemia (HP:0003139)2.87055489
27Agammaglobulinemia (HP:0004432)2.85368199
28Recurrent bacterial skin infections (HP:0005406)2.85017390
29Cellulitis (HP:0100658)2.82461488
30Vaginal atresia (HP:0000148)2.79520552
31Petechiae (HP:0000967)2.75134220
32Abnormal respiratory motile cilium morphology (HP:0005938)2.72947647
33Abnormal respiratory epithelium morphology (HP:0012253)2.72947647
34Hypoplasia of the thymus (HP:0000778)2.61435179
35Excessive salivation (HP:0003781)2.60821149
36Aplasia/Hypoplasia of the tongue (HP:0010295)2.58642796
37Mediastinal lymphadenopathy (HP:0100721)2.58640741
38Cutaneous melanoma (HP:0012056)2.56190929
39Meningitis (HP:0001287)2.55795263
40Spinal cord lesions (HP:0100561)2.55723638
41Syringomyelia (HP:0003396)2.55723638
42Volvulus (HP:0002580)2.55273007
43Aplasia/Hypoplasia of the tibia (HP:0005772)2.54960552
44Postaxial hand polydactyly (HP:0001162)2.54044608
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.53058119
46Prolonged bleeding time (HP:0003010)2.50393540
47Recurrent fungal infections (HP:0002841)2.50041868
48Asymmetry of the thorax (HP:0001555)2.48152719
49Disinhibition (HP:0000734)2.48004965
50Pulmonary infiltrates (HP:0002113)2.47982091
51Methylmalonic acidemia (HP:0002912)2.47161115
52Abnormality of the renal medulla (HP:0100957)2.42711604
53Postaxial foot polydactyly (HP:0001830)2.42508310
54Focal motor seizures (HP:0011153)2.40486207
55Short tibia (HP:0005736)2.38890677
56Broad-based gait (HP:0002136)2.38415984
57Short 4th metacarpal (HP:0010044)2.38384906
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.38384906
59Thyroiditis (HP:0100646)2.36529780
60Limb dystonia (HP:0002451)2.35241227
61Oligodactyly (hands) (HP:0001180)2.33268342
62Occipital encephalocele (HP:0002085)2.32641384
63Focal seizures (HP:0007359)2.32543844
64Increased cerebral lipofuscin (HP:0011813)2.31740743
65Retrobulbar optic neuritis (HP:0100654)2.31566799
66Optic neuritis (HP:0100653)2.31566799
67Action tremor (HP:0002345)2.31286053
68Reduced antithrombin III activity (HP:0001976)2.28676929
69Abnormality of the columella (HP:0009929)2.28548741
70Abnormal ciliary motility (HP:0012262)2.27230974
71Atonic seizures (HP:0010819)2.27200874
72Chronic hepatic failure (HP:0100626)2.25915181
73Progressive macrocephaly (HP:0004481)2.24249788
74Hemiparesis (HP:0001269)2.23457247
75IgG deficiency (HP:0004315)2.23428073
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.21746202
77Absent/shortened dynein arms (HP:0200106)2.21746202
78Cystic liver disease (HP:0006706)2.21489794
79Inappropriate behavior (HP:0000719)2.20832369
80Type II lissencephaly (HP:0007260)2.19992131
81Orchitis (HP:0100796)2.19668342
82Optic nerve hypoplasia (HP:0000609)2.19430687
83Febrile seizures (HP:0002373)2.18886195
84Abnormality of T cells (HP:0002843)2.18548128
85Type I transferrin isoform profile (HP:0003642)2.18183792
86Abnormality of B cell number (HP:0010975)2.16290821
87B lymphocytopenia (HP:0010976)2.16290821
88Lymphopenia (HP:0001888)2.15173525
89Chest pain (HP:0100749)2.15147255
90Myelodysplasia (HP:0002863)2.12875576
91T lymphocytopenia (HP:0005403)2.12295827
92Poor coordination (HP:0002370)2.11929821
93Abnormality of oral frenula (HP:0000190)2.11206180
94Abnormal delayed hypersensitivity skin test (HP:0002963)2.10299397
95Gastrointestinal atresia (HP:0002589)2.09418073
96Macroorchidism (HP:0000053)2.09240077
97Abnormality of the thoracic spine (HP:0100711)2.08118549
98Absent speech (HP:0001344)2.07831497
99Abnormality of the renal cortex (HP:0011035)2.07721807
100Eczematoid dermatitis (HP:0000976)2.07043359
101Heterochromia iridis (HP:0001100)2.06798318
102Colon cancer (HP:0003003)2.06722217
103Abnormality of T cell physiology (HP:0011840)2.05604884
104Septo-optic dysplasia (HP:0100842)2.05488135
105Progressive cerebellar ataxia (HP:0002073)2.05443780
106Anencephaly (HP:0002323)2.05353244
107Poikiloderma (HP:0001029)2.05020151
108Abnormality of the fingertips (HP:0001211)2.04495959
109Pachygyria (HP:0001302)2.03750282
110Progressive neurologic deterioration (HP:0002344)2.03617244
111Spondylolisthesis (HP:0003302)2.03551966
112Abnormality of the labia minora (HP:0012880)2.02836643
113Facial hemangioma (HP:0000329)2.02313679
114Birth length less than 3rd percentile (HP:0003561)2.01914034
115Recurrent skin infections (HP:0001581)2.01872942
116Renal cortical cysts (HP:0000803)2.01008348
117Narrow forehead (HP:0000341)2.00227057
118Gonadotropin excess (HP:0000837)1.99777606
119Abnormality of the lumbar spine (HP:0100712)1.99562192
120Medulloblastoma (HP:0002885)1.98935562
121Specific learning disability (HP:0001328)1.98223891
122Median cleft lip (HP:0000161)1.97448474
123Entropion (HP:0000621)1.97104325
124Abnormality of cells of the lymphoid lineage (HP:0012140)1.96104747
125Sclerocornea (HP:0000647)1.95094340
126Acute necrotizing encephalopathy (HP:0006965)1.95069161
127Aqueductal stenosis (HP:0002410)1.94959862
128Acute myeloid leukemia (HP:0004808)1.94159091
129Tented upper lip vermilion (HP:0010804)1.93747944
130Type 2 muscle fiber atrophy (HP:0003554)1.93346459
131Progressive inability to walk (HP:0002505)1.93159241
132Broad foot (HP:0001769)1.92863891
133Arterial thrombosis (HP:0004420)1.92663835
134Hypoplastic pelvis (HP:0008839)1.92268756
135Encephalitis (HP:0002383)1.91959786
136Hyperglycinemia (HP:0002154)1.90411180
137Aplasia/Hypoplasia of the lens (HP:0008063)1.90257652
138Abnormal respiratory motile cilium physiology (HP:0012261)1.89767155
139Polyphagia (HP:0002591)1.89424565
140Preaxial hand polydactyly (HP:0001177)1.88921185
141Gaze-evoked nystagmus (HP:0000640)1.88458919
142Vasculitis (HP:0002633)1.88175824
143Neutropenia (HP:0001875)1.87248006
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86933210
145Abnormality of the prostate (HP:0008775)1.85536468
146Abnormality of T cell number (HP:0011839)1.85430326
147Thoracic kyphosis (HP:0002942)1.83992728
148Hypsarrhythmia (HP:0002521)1.83563984
149Dysdiadochokinesis (HP:0002075)1.83533946
150Short foot (HP:0001773)1.83468715
151Recurrent cutaneous fungal infections (HP:0011370)1.83388439
152Chronic mucocutaneous candidiasis (HP:0002728)1.83388439
153Abnormality of glycolipid metabolism (HP:0010969)1.83236424
154Abnormality of liposaccharide metabolism (HP:0010968)1.83236424
155Abnormality of glycosphingolipid metabolism (HP:0004343)1.83236424
156Renal hypoplasia (HP:0000089)1.83073786
157Abnormality of the metopic suture (HP:0005556)1.83036265
158Increased hepatocellular lipid droplets (HP:0006565)1.82415203
159Rhinitis (HP:0012384)1.82006302
160Inability to walk (HP:0002540)1.80889437
161Neoplasm of the oral cavity (HP:0100649)1.80810456
162EEG with generalized epileptiform discharges (HP:0011198)1.80642164
163Male pseudohermaphroditism (HP:0000037)1.80376454
164Muscle fiber atrophy (HP:0100295)1.79545606
165Chronic obstructive pulmonary disease (HP:0006510)1.79495587
166Obstructive lung disease (HP:0006536)1.79495587
167Epileptiform EEG discharges (HP:0011182)1.79325766
168Spinal canal stenosis (HP:0003416)1.79166683
169Abnormal protein glycosylation (HP:0012346)1.78999918
170Abnormal glycosylation (HP:0012345)1.78999918
171Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78999918
172Abnormal protein N-linked glycosylation (HP:0012347)1.78999918
173Thyroid-stimulating hormone excess (HP:0002925)1.78847890
174Chronic sinusitis (HP:0011109)1.78253736
175Bifid tongue (HP:0010297)1.78212750
176Long clavicles (HP:0000890)1.77458920
177Viral hepatitis (HP:0006562)1.76514830
178Hip dysplasia (HP:0001385)1.76433539
179Recurrent pneumonia (HP:0006532)1.76432675
1803-Methylglutaconic aciduria (HP:0003535)1.76255899
181Periodontitis (HP:0000704)1.74373401
182Lissencephaly (HP:0001339)1.71942007
183Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.70743388
184Premature skin wrinkling (HP:0100678)1.70390048
185Stomach cancer (HP:0012126)1.70188916
186Lymphoma (HP:0002665)1.70037310
187Gastrointestinal inflammation (HP:0004386)1.68738874
188Mitochondrial inheritance (HP:0001427)1.67755912
189Akinesia (HP:0002304)1.67121706
190Abnormal hair whorl (HP:0010721)1.66518243
191Papillary thyroid carcinoma (HP:0002895)1.66437998
192Supernumerary spleens (HP:0009799)1.65994440
193Decreased testicular size (HP:0008734)1.65899567
194Increased density of long bones (HP:0006392)1.65706355
195Amyotrophic lateral sclerosis (HP:0007354)1.65697190
196Lipid accumulation in hepatocytes (HP:0006561)1.64566957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.47327673
2SIK33.34076358
3WNK33.28229913
4MAP4K12.90097344
5CCNB12.89815973
6MAP3K122.85357106
7MAP4K22.74389723
8TRIM282.68040563
9EPHA42.48348312
10TXK2.44535456
11TNIK2.42059807
12PRPF4B2.41413349
13KIT2.32837503
14BCR2.27030873
15IRAK42.26107906
16PLK22.09322081
17CLK12.06168667
18NUAK12.01431552
19MAP3K41.93314200
20PNCK1.87373580
21TEC1.83615449
22ACVR1B1.81341273
23BTK1.77647594
24JAK31.77398842
25PAK31.75173359
26STK38L1.74579881
27PIM21.70230099
28FES1.61868818
29EPHA31.61681140
30EEF2K1.59963259
31ERBB31.59366594
32SCYL21.56831490
33TGFBR11.53968516
34CDK191.53007949
35CAMKK21.52649380
36ITK1.49829545
37EIF2AK31.49518532
38CSNK1G11.48121622
39SYK1.46407807
40STK391.44907955
41UHMK11.44720502
42CSNK1G21.41509394
43MKNK11.40406377
44MKNK21.38445591
45PINK11.36146263
46CDC71.35794191
47RAF11.28098833
48STK101.27136214
49TNK21.25545004
50DYRK21.23251604
51CSNK1G31.23132596
52CDK81.18994280
53CSNK1A1L1.18249200
54TBK11.16433028
55FER1.13760996
56MAPK131.12656251
57MAP2K71.12235344
58BMPR1B1.11266073
59KSR11.07989305
60MST41.07207002
61STK161.06018483
62GRK11.05029226
63PRKCE1.03353885
64ZAP701.02920097
65OXSR11.00765806
66MARK11.00458696
67PKN21.00207745
68FGFR21.00173408
69AKT30.99305654
70INSRR0.98862032
71IKBKE0.97501935
72PASK0.97226074
73TAOK30.96687344
74FGFR30.94853809
75DAPK10.92954098
76NTRK30.92724811
77BRSK20.92707931
78CSF1R0.92349860
79BLK0.89441481
80HIPK20.88354696
81WEE10.87950828
82VRK10.86721690
83LCK0.85804611
84FRK0.85785976
85TAF10.85147764
86PLK30.84347629
87MAP3K140.83962794
88MAP3K130.83623358
89PKN10.81249409
90LYN0.79942527
91TYK20.78936608
92ADRBK20.78145264
93MARK30.77421328
94SRPK10.77174654
95PRKCG0.76287582
96DYRK30.76145346
97SIK20.75049660
98IRAK10.75046635
99NEK60.73572477
100CAMKK10.73215463
101RPS6KA20.73028470
102BCKDK0.72620911
103MAPKAPK50.72223093
104WNK40.72194848
105ZAK0.72023651
106HCK0.71627482
107CDK180.71468739
108EIF2AK10.70381698
109FLT30.68615299
110PIM10.67865523
111ATR0.67122590
112CDK60.64179017
113LRRK20.60506789
114CAMK2A0.59573536
115MINK10.59349337
116EPHB20.59130322
117RIPK40.58011787
118VRK20.57932313
119CDK150.57828413
120SGK20.55869098
121CDK11A0.54558292
122ERN10.53857840
123NEK90.53121251
124CDK90.52872486
125EPHB10.52756786
126MAPK40.52478059
127GRK50.52258793
128CDK140.52209844
129RPS6KB10.50304519
130MAP2K40.49940685
131JAK20.49214319
132ILK0.49040171
133PRKCQ0.49012211
134ADRBK10.48988876
135PAK60.48332126
136PRKCH0.47931810
137CDK40.47765235
138MARK20.46965972
139TRPM70.46860815
140RPS6KA40.43704000
141DAPK20.41883697
142STK110.41199833
143RPS6KA60.41178768
144CDK50.41171597
145CHUK0.40759435
146EIF2AK20.40738763
147PRKCI0.40508163
148LIMK10.40409448
149DYRK1A0.40275467
150MAP3K60.40233678
151CSNK1D0.39508615
152PRKACA0.39452644
153BRSK10.39169221
154YES10.38487009
155NTRK20.37996409
156CDK30.37090806
157NLK0.36736821
158ROCK10.36266012
159PHKG20.36137299
160PHKG10.36137299
161PRKACB0.35998522
162PRKG10.35503469
163CSNK1A10.35494742
164ERBB20.35327604
165PTK2B0.34804186
166SGK2230.34428348
167SGK4940.34428348
168SGK10.31093269
169ROCK20.30466944
170PLK10.27798692

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.67882177
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.99746045
3Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.65714263
4DNA replication_Homo sapiens_hsa030302.61194307
5Nicotine addiction_Homo sapiens_hsa050332.57149170
6Butanoate metabolism_Homo sapiens_hsa006502.32727068
7Propanoate metabolism_Homo sapiens_hsa006402.27937919
8Steroid biosynthesis_Homo sapiens_hsa001002.20434549
9Primary immunodeficiency_Homo sapiens_hsa053402.18990949
10Phototransduction_Homo sapiens_hsa047442.04403534
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.00496200
12B cell receptor signaling pathway_Homo sapiens_hsa046621.96026316
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.88597130
14Leishmaniasis_Homo sapiens_hsa051401.84562307
15Base excision repair_Homo sapiens_hsa034101.83705331
16Basal transcription factors_Homo sapiens_hsa030221.81349032
17Mismatch repair_Homo sapiens_hsa034301.80578705
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75657151
19Circadian rhythm_Homo sapiens_hsa047101.75592678
20Oxidative phosphorylation_Homo sapiens_hsa001901.75029019
21Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71658551
22Fatty acid elongation_Homo sapiens_hsa000621.69148619
23Regulation of autophagy_Homo sapiens_hsa041401.62364200
24Cell cycle_Homo sapiens_hsa041101.62219103
25GABAergic synapse_Homo sapiens_hsa047271.58435454
26Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.57884696
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.57569202
28Non-homologous end-joining_Homo sapiens_hsa034501.55514427
29T cell receptor signaling pathway_Homo sapiens_hsa046601.52633379
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.48681953
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.46624949
32Taste transduction_Homo sapiens_hsa047421.41661054
33Colorectal cancer_Homo sapiens_hsa052101.41599231
34Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.39820380
35Osteoclast differentiation_Homo sapiens_hsa043801.39398515
36N-Glycan biosynthesis_Homo sapiens_hsa005101.37468533
37Pancreatic cancer_Homo sapiens_hsa052121.36394936
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.34458246
39Insulin secretion_Homo sapiens_hsa049111.33976598
40Glutamatergic synapse_Homo sapiens_hsa047241.33748860
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32447960
42Hepatitis B_Homo sapiens_hsa051611.31151926
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30751248
44Chronic myeloid leukemia_Homo sapiens_hsa052201.29670000
45Platelet activation_Homo sapiens_hsa046111.29556178
46Measles_Homo sapiens_hsa051621.29277375
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27922624
48Neurotrophin signaling pathway_Homo sapiens_hsa047221.27858798
49Shigellosis_Homo sapiens_hsa051311.26523674
50Hedgehog signaling pathway_Homo sapiens_hsa043401.26375745
51beta-Alanine metabolism_Homo sapiens_hsa004101.22850491
52Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.21640883
53Antigen processing and presentation_Homo sapiens_hsa046121.20665503
54Chemokine signaling pathway_Homo sapiens_hsa040621.19585080
55Parkinsons disease_Homo sapiens_hsa050121.19242871
56NF-kappa B signaling pathway_Homo sapiens_hsa040641.17611531
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16922537
58Non-small cell lung cancer_Homo sapiens_hsa052231.15705850
59Collecting duct acid secretion_Homo sapiens_hsa049661.15104010
60Hematopoietic cell lineage_Homo sapiens_hsa046401.14677281
61Amphetamine addiction_Homo sapiens_hsa050311.14103115
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.12053680
63Peroxisome_Homo sapiens_hsa041461.11804824
64Spliceosome_Homo sapiens_hsa030401.09081189
65Nitrogen metabolism_Homo sapiens_hsa009101.08298785
66Protein export_Homo sapiens_hsa030601.04324945
67Serotonergic synapse_Homo sapiens_hsa047261.03355486
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.03300026
69Basal cell carcinoma_Homo sapiens_hsa052171.03273919
70Huntingtons disease_Homo sapiens_hsa050161.02673852
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02016213
72Ether lipid metabolism_Homo sapiens_hsa005651.00717389
73Sphingolipid signaling pathway_Homo sapiens_hsa040711.00224546
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98707974
75Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.97996579
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97924062
77Tuberculosis_Homo sapiens_hsa051520.96990993
78Fatty acid metabolism_Homo sapiens_hsa012120.95928674
79Nucleotide excision repair_Homo sapiens_hsa034200.95077511
80Herpes simplex infection_Homo sapiens_hsa051680.94035117
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93643521
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.91302895
83Alzheimers disease_Homo sapiens_hsa050100.91302088
84Salivary secretion_Homo sapiens_hsa049700.90665468
85Synaptic vesicle cycle_Homo sapiens_hsa047210.90621103
86Olfactory transduction_Homo sapiens_hsa047400.90476484
87RNA polymerase_Homo sapiens_hsa030200.90385479
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90347383
89Pertussis_Homo sapiens_hsa051330.90318347
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89055749
91Linoleic acid metabolism_Homo sapiens_hsa005910.88743814
92Toxoplasmosis_Homo sapiens_hsa051450.88692244
93Caffeine metabolism_Homo sapiens_hsa002320.88201596
94Cocaine addiction_Homo sapiens_hsa050300.88192526
95NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87657471
96RNA degradation_Homo sapiens_hsa030180.87182247
97Renin secretion_Homo sapiens_hsa049240.86351300
98p53 signaling pathway_Homo sapiens_hsa041150.84728606
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83649096
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.83517525
101Endometrial cancer_Homo sapiens_hsa052130.81737642
102Acute myeloid leukemia_Homo sapiens_hsa052210.81270332
103Salmonella infection_Homo sapiens_hsa051320.81212989
104Homologous recombination_Homo sapiens_hsa034400.80769755
105Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80385313
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80231717
107Cardiac muscle contraction_Homo sapiens_hsa042600.79967247
108Morphine addiction_Homo sapiens_hsa050320.79780882
109Malaria_Homo sapiens_hsa051440.78361932
110Legionellosis_Homo sapiens_hsa051340.77730659
111Cholinergic synapse_Homo sapiens_hsa047250.75965699
112Allograft rejection_Homo sapiens_hsa053300.75884890
113Viral myocarditis_Homo sapiens_hsa054160.75824084
114Glioma_Homo sapiens_hsa052140.74902847
115Apoptosis_Homo sapiens_hsa042100.74517259
116Axon guidance_Homo sapiens_hsa043600.73699138
117Hippo signaling pathway_Homo sapiens_hsa043900.72853899
118Long-term potentiation_Homo sapiens_hsa047200.71999604
119HTLV-I infection_Homo sapiens_hsa051660.71733699
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.71297108
121VEGF signaling pathway_Homo sapiens_hsa043700.70714952
122Viral carcinogenesis_Homo sapiens_hsa052030.70238326
123Selenocompound metabolism_Homo sapiens_hsa004500.70206962
124Thyroid cancer_Homo sapiens_hsa052160.69443568
125Other glycan degradation_Homo sapiens_hsa005110.68797041
126Lysosome_Homo sapiens_hsa041420.68740749
127TNF signaling pathway_Homo sapiens_hsa046680.68307065
128MicroRNAs in cancer_Homo sapiens_hsa052060.67171331
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67015896
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65871668
131Type I diabetes mellitus_Homo sapiens_hsa049400.64681165
132Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64644921
133Influenza A_Homo sapiens_hsa051640.63997452
134Circadian entrainment_Homo sapiens_hsa047130.62975025
135Wnt signaling pathway_Homo sapiens_hsa043100.62804780
136Endocytosis_Homo sapiens_hsa041440.62698179
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62592232
138cAMP signaling pathway_Homo sapiens_hsa040240.61671487
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61483367
140Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.60803226
141Prolactin signaling pathway_Homo sapiens_hsa049170.59785375
142Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59111463
143Gastric acid secretion_Homo sapiens_hsa049710.59072794
144Phagosome_Homo sapiens_hsa041450.58616477
145Epstein-Barr virus infection_Homo sapiens_hsa051690.58543187
146Dopaminergic synapse_Homo sapiens_hsa047280.58433598
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57927906
148TGF-beta signaling pathway_Homo sapiens_hsa043500.57795531
149Pyrimidine metabolism_Homo sapiens_hsa002400.56440245
150Tryptophan metabolism_Homo sapiens_hsa003800.56182749
151Oocyte meiosis_Homo sapiens_hsa041140.55539270
152Chemical carcinogenesis_Homo sapiens_hsa052040.55388840
153Sulfur metabolism_Homo sapiens_hsa009200.54732965
154Small cell lung cancer_Homo sapiens_hsa052220.54610294
155Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54075036
156Fanconi anemia pathway_Homo sapiens_hsa034600.53537474
157mRNA surveillance pathway_Homo sapiens_hsa030150.53138531
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.53114120
159Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52394839
160Phospholipase D signaling pathway_Homo sapiens_hsa040720.51523551
161Gap junction_Homo sapiens_hsa045400.51448526
162Alcoholism_Homo sapiens_hsa050340.51334339
163Glycerolipid metabolism_Homo sapiens_hsa005610.50519054
164Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49971378
165Calcium signaling pathway_Homo sapiens_hsa040200.49796781
166Oxytocin signaling pathway_Homo sapiens_hsa049210.46686681
167Long-term depression_Homo sapiens_hsa047300.46297868
168Phosphatidylinositol signaling system_Homo sapiens_hsa040700.46066127
169cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45924782
170Dorso-ventral axis formation_Homo sapiens_hsa043200.45463935
171ErbB signaling pathway_Homo sapiens_hsa040120.45349175
172Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45059193
173Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44272363
174Melanoma_Homo sapiens_hsa052180.43695425
175Melanogenesis_Homo sapiens_hsa049160.41239879
176Steroid hormone biosynthesis_Homo sapiens_hsa001400.41221584
177Primary bile acid biosynthesis_Homo sapiens_hsa001200.40907708
178Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40458961
179Vascular smooth muscle contraction_Homo sapiens_hsa042700.38281767
180Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37636476
181Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37404484
182Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37086586

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