ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of DNA methylation (GO:0044030)	9.41122858
2	regulation of female gonad development (GO:2000194)	9.11707480
3	regulation of acrosome reaction (GO:0060046)	7.45945681
4	meiotic cell cycle (GO:0051321)	7.08323241
5	positive regulation of humoral immune response (GO:0002922)	7.00760891
6	regulation of meiosis I (GO:0060631)	6.99189167
7	piRNA metabolic process (GO:0034587)	6.91965520
8	regulation of histone H3-K9 methylation (GO:0051570)	6.47143870
9	retinal cone cell development (GO:0046549)	6.18718565
10	oocyte development (GO:0048599)	6.08566127
11	multicellular organism reproduction (GO:0032504)	6.04917133
12	positive regulation of histone H3-K4 methylation (GO:0051571)	5.87844824
13	protein kinase C signaling (GO:0070528)	5.76666143
14	DNA methylation involved in gamete generation (GO:0043046)	5.75996334
15	negative regulation of histone methylation (GO:0031061)	5.49677213
16	female gamete generation (GO:0007292)	5.47483423
17	regulation of steroid hormone secretion (GO:2000831)	5.01695951
18	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	5.01204118
19	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	5.01204118
20	positive regulation of mitotic sister chromatid separation (GO:1901970)	5.01204118
21	negative regulation of reproductive process (GO:2000242)	4.90367172
22	regulation of cell maturation (GO:1903429)	4.85039701
23	mitotic chromosome condensation (GO:0007076)	4.65776747
24	gene silencing by RNA (GO:0031047)	4.63290195
25	glycine transport (GO:0015816)	4.61924117
26	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	4.57138428
27	negative regulation of execution phase of apoptosis (GO:1900118)	4.47809601
28	positive regulation of histone methylation (GO:0031062)	4.16054210
29	protein localization to kinetochore (GO:0034501)	4.14754826
30	negative regulation of cAMP-mediated signaling (GO:0043951)	4.10136629
31	positive regulation of chromosome segregation (GO:0051984)	4.07827406
32	protein localization to chromosome, centromeric region (GO:0071459)	4.05728392
33	establishment of chromosome localization (GO:0051303)	4.04993296
34	positive regulation of isotype switching (GO:0045830)	4.00877591
35	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	4.00752976
36	reproduction (GO:0000003)	3.99086444
37	centriole replication (GO:0007099)	3.88574667
38	regulation of retinoic acid receptor signaling pathway (GO:0048385)	3.86794783
39	positive regulation of gastrulation (GO:2000543)	3.79280093
40	mitotic metaphase plate congression (GO:0007080)	3.78634845
41	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	3.75060138
42	primitive streak formation (GO:0090009)	3.73364559
43	citrulline biosynthetic process (GO:0019240)	3.68100154
44	regulation of histone methylation (GO:0031060)	3.67186375
45	regulation of histone H3-K4 methylation (GO:0051569)	3.64137540
46	synapsis (GO:0007129)	3.52681604
47	male meiosis I (GO:0007141)	3.52200248
48	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.48181092
49	regulation of isotype switching to IgG isotypes (GO:0048302)	3.47943209
50	positive regulation of DNA recombination (GO:0045911)	3.44400635
51	DNA methylation (GO:0006306)	3.44239145
52	DNA alkylation (GO:0006305)	3.44239145
53	stress granule assembly (GO:0034063)	3.42237907
54	regulation of meiosis (GO:0040020)	3.40549308
55	synaptonemal complex assembly (GO:0007130)	3.39091151
56	positive regulation of uterine smooth muscle contraction (GO:0070474)	3.35576023
57	regulation of steroid hormone biosynthetic process (GO:0090030)	3.30893283
58	negative regulation of histone modification (GO:0031057)	3.23677614
59	gene silencing (GO:0016458)	3.20989806
60	regulation of hypersensitivity (GO:0002883)	3.19568421
61	protein localization to chromosome (GO:0034502)	3.18534477
62	tolerance induction (GO:0002507)	3.17349649
63	binding of sperm to zona pellucida (GO:0007339)	3.16768985
64	male meiosis (GO:0007140)	3.15965197
65	fertilization (GO:0009566)	3.13816148
66	regulation of chronic inflammatory response (GO:0002676)	3.13102107
67	chromosome organization involved in meiosis (GO:0070192)	3.13020723
68	regulation of isotype switching (GO:0045191)	3.06222750
69	negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736)	3.06091451
70	oogenesis (GO:0048477)	3.03149105
71	metaphase plate congression (GO:0051310)	3.02352827
72	synaptonemal complex organization (GO:0070193)	3.00279955
73	regulation of interleukin-13 production (GO:0032656)	3.00107353
74	regulation of gamma-delta T cell differentiation (GO:0045586)	2.99581381
75	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.97344608
76	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.96892137
77	negative thymic T cell selection (GO:0045060)	2.96399716
78	negative T cell selection (GO:0043383)	2.95813450
79	somite rostral/caudal axis specification (GO:0032525)	2.94170584
80	nucleus organization (GO:0006997)	2.93975264
81	meiotic nuclear division (GO:0007126)	2.92535822
82	positive regulation of reproductive process (GO:2000243)	2.92427400
83	CENP-A containing nucleosome assembly (GO:0034080)	2.92246673
84	centrosome duplication (GO:0051298)	2.90558173
85	phosphorelay signal transduction system (GO:0000160)	2.89736674
86	meiosis I (GO:0007127)	2.89666398
87	regulation of spindle checkpoint (GO:0090231)	2.89476473
88	N-terminal protein amino acid acetylation (GO:0006474)	2.88361784
89	regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)	2.87985732
90	negative regulation of chromatin modification (GO:1903309)	2.87200751
91	positive regulation of immunoglobulin production (GO:0002639)	2.84395969
92	phosphatidylinositol dephosphorylation (GO:0046856)	2.82516150
93	positive regulation of interleukin-2 biosynthetic process (GO:0045086)	2.80408181
94	meiotic cell cycle process (GO:1903046)	2.80135192
95	regulation of meiotic cell cycle (GO:0051445)	2.79285992
96	L-amino acid import (GO:0043092)	2.79214986
97	regulation of chromatin silencing (GO:0031935)	2.78749732
98	attachment of spindle microtubules to kinetochore (GO:0008608)	2.76577584
99	labyrinthine layer development (GO:0060711)	2.73542253
100	DNA damage induced protein phosphorylation (GO:0006975)	2.73095816

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	6.37260357
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.26371418
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.48966485
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.21523173
5	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	3.94740995
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.68338310
7	E2F7_22180533_ChIP-Seq_HELA_Human	3.50881849
8	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	3.01514188
9	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	2.96155460
10	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	2.96155460
11	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	2.96155460
12	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.58843912
13	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.38723991
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.36874781
15	RUNX_20019798_ChIP-Seq_JUKART_Human	2.21051043
16	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.10265776
17	EZH2_22144423_ChIP-Seq_EOC_Human	12.3602292
18	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.96233054
19	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.81009534
20	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.79775002
21	MYB_26560356_Chip-Seq_TH2_Human	1.51190722
22	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.49940745
23	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.47170453
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.46333149
25	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.41496970
26	MYB_26560356_Chip-Seq_TH1_Human	1.35341310
27	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.33790102
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30113759
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.29623091
30	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.29083366
31	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	1.28025267
32	PKCTHETA_26484144_Chip-Seq_BREAST_Human	1.23026667
33	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.20778218
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.20512411
35	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.17752581
36	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.16506878
37	VDR_23849224_ChIP-Seq_CD4+_Human	1.11296863
38	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.11230147
39	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.10217190
40	SMRT_27268052_Chip-Seq_Bcells_Human	1.07864631
41	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.07814026
42	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.03068054
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.01782111
44	GATA3_26560356_Chip-Seq_TH1_Human	0.98641333
45	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.97429186
46	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.96185374
47	GATA3_27048872_Chip-Seq_THYMUS_Human	0.95882049
48	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.94466551
49	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.92225908
50	GBX2_23144817_ChIP-Seq_PC3_Human	0.90530556
51	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.90019525
52	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.89100871
53	NANOG_20526341_ChIP-Seq_ESCs_Human	0.88790993
54	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.85734892
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.84675691
56	CBP_20019798_ChIP-Seq_JUKART_Human	0.84675691
57	GATA3_26560356_Chip-Seq_TH2_Human	0.83073337
58	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.80224671
59	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.79502426
60	TCF4_23295773_ChIP-Seq_U87_Human	0.79209656
61	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.78894742
62	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.78246337
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.77303727
64	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	0.76213800
65	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.76182026
66	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.72508062
67	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.72488344
68	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	0.72033894
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.71871687
70	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.71755411
71	GF1_26923725_Chip-Seq_HPCs_Mouse	0.71183950
72	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.71126156
73	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	0.70228913
74	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.69196112
75	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.69156323
76	EST1_17652178_ChIP-ChIP_JURKAT_Human	0.68471198
77	UTX_26944678_Chip-Seq_JUKART_Human	0.67648820
78	MYC_18940864_ChIP-ChIP_HL60_Human	0.66762939
79	BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human	0.66722197
80	AR_21909140_ChIP-Seq_LNCAP_Human	0.66692248
81	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.65687247
82	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.65670579
83	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.65529857
84	KLF4_19829295_ChIP-Seq_ESCs_Human	0.64987005
85	STAT3_23295773_ChIP-Seq_U87_Human	0.62694749
86	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.62437314
87	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.61960999
88	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.60479029
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.57317569
90	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.57247750
91	ELK4_26923725_Chip-Seq_MESODERM_Mouse	0.55457057
92	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.55167799
93	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.54795493
94	AR_25329375_ChIP-Seq_VCAP_Human	0.54203824
95	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.53076753
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.52906190
97	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.52491678
98	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.52491678
99	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	0.52473871
100	NANOG_18555785_ChIP-Seq_MESCs_Mouse	0.51891319

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003718_maternal_effect	7.66532373
2	MP0002138_abnormal_hepatobiliary_system	4.52654792
3	MP0008877_abnormal_DNA_methylation	4.13172463
4	MP0008789_abnormal_olfactory_epithelium	3.72576907
5	MP0006292_abnormal_olfactory_placode	3.48345063
6	MP0005394_taste/olfaction_phenotype	3.32385727
7	MP0005499_abnormal_olfactory_system	3.32385727
8	MP0002139_abnormal_hepatobiliary_system	3.17255372
9	MP0005395_other_phenotype	3.06687598
10	MP0008057_abnormal_DNA_replication	2.92680232
11	MP0001873_stomach_inflammation	2.77586200
12	MP0003890_abnormal_embryonic-extraembry	2.64329957
13	MP0003693_abnormal_embryo_hatching	2.50544899
14	MP0003699_abnormal_female_reproductive	2.49870138
15	MP0003183_abnormal_peptide_metabolism	2.23141926
16	MP0005360_urolithiasis	2.21161094
17	MP0003077_abnormal_cell_cycle	2.04987759
18	MP0010094_abnormal_chromosome_stability	1.99048495
19	MP0002234_abnormal_pharynx_morphology	1.96905927
20	MP0001929_abnormal_gametogenesis	1.95979896
21	MP0010030_abnormal_orbit_morphology	1.87226266
22	MP0002210_abnormal_sex_determination	1.87208601
23	MP0008058_abnormal_DNA_repair	1.84992627
24	MP0003763_abnormal_thymus_physiology	1.84321851
25	MP0010234_abnormal_vibrissa_follicle	1.75241999
26	MP0003252_abnormal_bile_duct	1.74992646
27	MP0009840_abnormal_foam_cell	1.62163627
28	MP0003111_abnormal_nucleus_morphology	1.60988672
29	MP0000685_abnormal_immune_system	1.57974405
30	MP0005410_abnormal_fertilization	1.54322136
31	MP0000653_abnormal_sex_gland	1.48715563
32	MP0001730_embryonic_growth_arrest	1.47536796
33	MP0002161_abnormal_fertility/fecundity	1.46407519
34	MP0001348_abnormal_lacrimal_gland	1.44692666
35	MP0003950_abnormal_plasma_membrane	1.37027747
36	MP0001119_abnormal_female_reproductive	1.33925346
37	MP0005671_abnormal_response_to	1.29345720
38	MP0010307_abnormal_tumor_latency	1.29057622
39	MP0003879_abnormal_hair_cell	1.28852991
40	MP0005310_abnormal_salivary_gland	1.26967035
41	MP0009333_abnormal_splenocyte_physiolog	1.21902902
42	MP0001800_abnormal_humoral_immune	1.17295731
43	MP0005647_abnormal_sex_gland	1.16327134
44	MP0002160_abnormal_reproductive_system	1.13050803
45	MP0001145_abnormal_male_reproductive	1.12230552
46	MP0000703_abnormal_thymus_morphology	1.08906870
47	MP0002396_abnormal_hematopoietic_system	1.08292548
48	MP0005389_reproductive_system_phenotype	1.06059638
49	MP0008995_early_reproductive_senescence	1.04448852
50	MP0000350_abnormal_cell_proliferation	1.02402820
51	MP0010368_abnormal_lymphatic_system	1.02208444
52	MP0002398_abnormal_bone_marrow	1.02008641
53	MP0002420_abnormal_adaptive_immunity	0.94239793
54	MP0005000_abnormal_immune_tolerance	0.93077083
55	MP0001819_abnormal_immune_cell	0.91095377
56	MP0003436_decreased_susceptibility_to	0.89900415
57	MP0001293_anophthalmia	0.88566496
58	MP0002723_abnormal_immune_serum	0.86987457
59	MP0000762_abnormal_tongue_morphology	0.86600892
60	MP0008932_abnormal_embryonic_tissue	0.86013219
61	MP0005646_abnormal_pituitary_gland	0.85366357
62	MP0002452_abnormal_antigen_presenting	0.84963694
63	MP0003698_abnormal_male_reproductive	0.84808238
64	MP0002163_abnormal_gland_morphology	0.83781350
65	MP0001666_abnormal_nutrient_absorption	0.82697140
66	MP0005387_immune_system_phenotype	0.82395407
67	MP0001790_abnormal_immune_system	0.82395407
68	MP0001672_abnormal_embryogenesis/_devel	0.82050347
69	MP0005380_embryogenesis_phenotype	0.82050347
70	MP0003786_premature_aging	0.80954676
71	MP0000678_abnormal_parathyroid_gland	0.80162087
72	MP0003868_abnormal_feces_composition	0.79628685
73	MP0001919_abnormal_reproductive_system	0.79042980
74	MP0000716_abnormal_immune_system	0.78856198
75	MP0004947_skin_inflammation	0.78770385
76	MP0004381_abnormal_hair_follicle	0.78313507
77	MP0000689_abnormal_spleen_morphology	0.77765664
78	MP0006082_CNS_inflammation	0.77729934
79	MP0003121_genomic_imprinting	0.76604812
80	MP0002722_abnormal_immune_system	0.75733470
81	MP0002019_abnormal_tumor_incidence	0.75153655
82	MP0004957_abnormal_blastocyst_morpholog	0.74487837
83	MP0000631_abnormal_neuroendocrine_gland	0.74065969
84	MP0000465_gastrointestinal_hemorrhage	0.73894692
85	MP0000427_abnormal_hair_cycle	0.73337782
86	MP0001984_abnormal_olfaction	0.72276801
87	MP0002006_tumorigenesis	0.71235042
88	MP0002254_reproductive_system_inflammat	0.70150578
89	MP0005085_abnormal_gallbladder_physiolo	0.70020719
90	MP0010678_abnormal_skin_adnexa	0.68305465
91	MP0005076_abnormal_cell_differentiation	0.67312782
92	MP0000566_synostosis	0.64478656
93	MP0002089_abnormal_postnatal_growth/wei	0.64051727
94	MP0001986_abnormal_taste_sensitivity	0.60834502
95	MP0003959_abnormal_lean_body	0.59625119
96	MP0002429_abnormal_blood_cell	0.59112232
97	MP0009785_altered_susceptibility_to	0.58749474
98	MP0002405_respiratory_system_inflammati	0.58218386
99	MP0010155_abnormal_intestine_physiology	0.53068831
100	MP0002928_abnormal_bile_duct	0.52971127

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Supernumerary spleens (HP:0009799)	5.64538591
2	Abdominal situs inversus (HP:0003363)	5.31643538
3	Abnormality of abdominal situs (HP:0011620)	5.31643538
4	Facial hemangioma (HP:0000329)	5.17721418
5	Impulsivity (HP:0100710)	4.86932858
6	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	4.79053866
7	Abnormal gallbladder physiology (HP:0012438)	4.48131445
8	Cholecystitis (HP:0001082)	4.48131445
9	Aplasia/Hypoplasia of the fovea (HP:0008060)	4.32610399
10	Hypoplasia of the fovea (HP:0007750)	4.32610399
11	Lip pit (HP:0100267)	4.03506456
12	Hypophosphatemic rickets (HP:0004912)	3.98853546
13	Anterior segment dysgenesis (HP:0007700)	3.91895072
14	Oligodactyly (hands) (HP:0001180)	3.67854026
15	Osteomalacia (HP:0002749)	3.63607341
16	Abnormality of the fovea (HP:0000493)	3.58422555
17	Chromsome breakage (HP:0040012)	3.44573190
18	Male infertility (HP:0003251)	3.41037885
19	Capillary hemangiomas (HP:0005306)	3.40999969
20	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.37108284
21	Azoospermia (HP:0000027)	3.30213035
22	Septo-optic dysplasia (HP:0100842)	3.22991897
23	Infertility (HP:0000789)	3.17933620
24	Stomatitis (HP:0010280)	3.14222268
25	Malnutrition (HP:0004395)	3.12784483
26	Premature ovarian failure (HP:0008209)	3.07318402
27	Prostate neoplasm (HP:0100787)	2.96332591
28	Dysmetric saccades (HP:0000641)	2.93440563
29	Short tibia (HP:0005736)	2.92273504
30	Combined immunodeficiency (HP:0005387)	2.90335914
31	Elevated circulating parathyroid hormone (PTH) level (HP:0003165)	2.85981122
32	Absent septum pellucidum (HP:0001331)	2.81669648
33	Fair hair (HP:0002286)	2.81492494
34	Abnormality of the septum pellucidum (HP:0007375)	2.76620069
35	Gonadotropin excess (HP:0000837)	2.74337537
36	Hypokinesia (HP:0002375)	2.73284511
37	Aplasia/Hypoplasia of the macula (HP:0008059)	2.71572061
38	Dysdiadochokinesis (HP:0002075)	2.70404773
39	Papillary thyroid carcinoma (HP:0002895)	2.69574014
40	Median cleft lip (HP:0000161)	2.62752050
41	Oligodactyly (HP:0012165)	2.58566006
42	Wrist flexion contracture (HP:0001239)	2.57820562
43	Abnormal spermatogenesis (HP:0008669)	2.55840597
44	Stillbirth (HP:0003826)	2.52696116
45	Severe combined immunodeficiency (HP:0004430)	2.52015966
46	Anhidrosis (HP:0000970)	2.51339864
47	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.50984450
48	Apathy (HP:0000741)	2.49239324
49	Striae distensae (HP:0001065)	2.48077897
50	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.47573713
51	Abnormality of the labia minora (HP:0012880)	2.39391074
52	Hypercortisolism (HP:0001578)	2.34704071
53	Metaphyseal irregularity (HP:0003025)	2.33789920
54	Truncal obesity (HP:0001956)	2.32863195
55	Diminished motivation (HP:0000745)	2.30829962
56	Spinal cord compression (HP:0002176)	2.29291442
57	Urethral obstruction (HP:0000796)	2.29169007
58	IgG deficiency (HP:0004315)	2.24746753
59	Heterotopia (HP:0002282)	2.20349169
60	Enlarged penis (HP:0000040)	2.18928470
61	Lower limb hyperreflexia (HP:0002395)	2.16586632
62	Pustule (HP:0200039)	2.15253861
63	Impaired smooth pursuit (HP:0007772)	2.15128834
64	Posterior subcapsular cataract (HP:0007787)	2.12492977
65	Nephroblastoma (Wilms tumor) (HP:0002667)	2.10114140
66	Aplastic anemia (HP:0001915)	2.08241399
67	Abnormality of the phalanges of the hallux (HP:0010057)	2.07986266
68	Hypergonadotropic hypogonadism (HP:0000815)	2.06388468
69	Maternal diabetes (HP:0009800)	2.05278571
70	Generalized hypopigmentation of hair (HP:0011358)	2.03332750
71	Hypoplasia of the uterus (HP:0000013)	2.02670541
72	Skin pits (HP:0100276)	1.99553376
73	Congenital sensorineural hearing impairment (HP:0008527)	1.98072047
74	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	1.97283488
75	T lymphocytopenia (HP:0005403)	1.97262060
76	IgA deficiency (HP:0002720)	1.97256039
77	Abnormality of chromosome segregation (HP:0002916)	1.95846298
78	Generalized aminoaciduria (HP:0002909)	1.95264908
79	Embryonal renal neoplasm (HP:0011794)	1.94945326
80	Cleft eyelid (HP:0000625)	1.94518168
81	Intrahepatic cholestasis (HP:0001406)	1.93376133
82	Abnormal biliary tract physiology (HP:0012439)	1.86360370
83	Bile duct proliferation (HP:0001408)	1.86360370
84	Abnormal lung lobation (HP:0002101)	1.84424175
85	Abnormality of the prostate (HP:0008775)	1.81091784
86	Limb hypertonia (HP:0002509)	1.81022861
87	Abnormality of T cell number (HP:0011839)	1.78952215
88	Muscle stiffness (HP:0003552)	1.77805318
89	Clubbing of toes (HP:0100760)	1.76601305
90	Gaze-evoked nystagmus (HP:0000640)	1.73023030
91	Peripheral hypomyelination (HP:0007182)	1.72156140
92	Abnormality of the preputium (HP:0100587)	1.70700738
93	Bicornuate uterus (HP:0000813)	1.70495587
94	Abnormality of chromosome stability (HP:0003220)	1.70081843
95	Cafe-au-lait spot (HP:0000957)	1.69277608
96	Abnormal foot bone ossification (HP:0010675)	1.68855370
97	Hyperactive renin-angiotensin system (HP:0000841)	1.68682206
98	Slow saccadic eye movements (HP:0000514)	1.67411776
99	Hypohidrosis (HP:0000966)	1.67234512
100	Conjunctival telangiectasia (HP:0000524)	1.67171543

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP3K9	5.80011899
2	MAP3K13	5.27743878
3	ARAF	4.53157024
4	CDK12	3.42909703
5	NEK6	3.19113070
6	CDK9	3.06656421
7	TAOK3	2.90327760
8	STK24	2.74531299
9	BRAF	2.35811365
10	TTK	2.08837676
11	PASK	2.04309027
12	TXK	1.95654077
13	MOS	1.91840784
14	AURKA	1.83164954
15	MAP3K14	1.83023144
16	MELK	1.81789834
17	EIF2AK3	1.76052718
18	CDK19	1.69347558
19	MET	1.67032766
20	MAP4K1	1.62976079
21	NTRK2	1.56544883
22	PRKCI	1.54439972
23	KSR2	1.52139307
24	CDK8	1.47119792
25	RAF1	1.46613939
26	MAP3K10	1.39546894
27	CDK7	1.39434047
28	CDC7	1.34623402
29	BRD4	1.32367844
30	CHUK	1.17094828
31	TNIK	1.11959129
32	STK3	1.11477969
33	PIM1	1.11222960
34	PRPF4B	1.06347836
35	ZAP70	1.04037526
36	MARK3	1.02882887
37	NUAK1	1.01926097
38	NEK9	1.00766053
39	ZAK	1.00526162
40	RIPK1	0.97096082
41	MST4	0.96383748
42	TNK2	0.94991933
43	CAMKK1	0.88813020
44	CHEK1	0.84506199
45	CAMKK2	0.83443158
46	ITK	0.83429328
47	IKBKB	0.80906574
48	IKBKE	0.80565038
49	PLK1	0.79940376
50	MAP3K8	0.77974243
51	KSR1	0.76469181
52	TRIM28	0.72240038
53	CDK2	0.70697330
54	PBK	0.67292988
55	CDK4	0.64632821
56	SRPK1	0.63042132
57	LCK	0.62748859
58	CHEK2	0.62429599
59	JAK3	0.59324465
60	WNK1	0.59022199
61	CSF1R	0.58011140
62	PDK1	0.56960150
63	FES	0.56879463
64	CSNK1D	0.55177060
65	BUB1	0.54803752
66	TGFBR1	0.54200289
67	EEF2K	0.54112667
68	TYRO3	0.52784670
69	ATM	0.52015799
70	AURKB	0.50860797
71	PRKCQ	0.50058584
72	TIE1	0.48329524
73	BRSK1	0.46755266
74	CSK	0.46425164
75	MTOR	0.46134999
76	ATR	0.45631336
77	NLK	0.45002448
78	MAP3K7	0.44880448
79	MAPK11	0.44171286
80	CDK1	0.39919287
81	LATS1	0.39700413
82	VRK1	0.39576294
83	TEC	0.35768509
84	PRKG1	0.35761020
85	STK4	0.35390371
86	NEK2	0.35217025
87	TRPM7	0.32888816
88	MAPKAPK3	0.31299050
89	MAPK1	0.29436575
90	DMPK	0.29369023
91	OXSR1	0.28411800
92	SIK2	0.26313741
93	PAK1	0.26052074
94	EGFR	0.25182293
95	EIF2AK2	0.25021245
96	CSNK1E	0.24476009
97	PKN1	0.24431777
98	RPS6KB2	0.22376977
99	PTK2	0.22106619
100	PLK3	0.20929362

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Basal transcription factors_Homo sapiens_hsa03022	4.20331513
2	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	4.03823633
3	Cell cycle_Homo sapiens_hsa04110	3.74567237
4	Primary immunodeficiency_Homo sapiens_hsa05340	2.71070684
5	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.60973968
6	Caffeine metabolism_Homo sapiens_hsa00232	2.59702479
7	Ovarian steroidogenesis_Homo sapiens_hsa04913	2.58034665
8	RNA degradation_Homo sapiens_hsa03018	2.52179739
9	T cell receptor signaling pathway_Homo sapiens_hsa04660	2.37707600
10	Oocyte meiosis_Homo sapiens_hsa04114	2.30218858
11	Mismatch repair_Homo sapiens_hsa03430	2.15857997
12	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	2.10669434
13	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.91754457
14	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.88253399
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.80644330
16	Homologous recombination_Homo sapiens_hsa03440	1.75536592
17	Allograft rejection_Homo sapiens_hsa05330	1.68040320
18	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.66291540
19	RNA transport_Homo sapiens_hsa03013	1.63400742
20	Nucleotide excision repair_Homo sapiens_hsa03420	1.60585406
21	Circadian rhythm_Homo sapiens_hsa04710	1.59575423
22	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.58191060
23	p53 signaling pathway_Homo sapiens_hsa04115	1.57025306
24	Base excision repair_Homo sapiens_hsa03410	1.55863827
25	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.53022314
26	Herpes simplex infection_Homo sapiens_hsa05168	1.44485839
27	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35105373
28	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31307313
29	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.28995172
30	Measles_Homo sapiens_hsa05162	1.27846393
31	DNA replication_Homo sapiens_hsa03030	1.26719498
32	Viral carcinogenesis_Homo sapiens_hsa05203	1.26626205
33	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	1.24525389
34	Asthma_Homo sapiens_hsa05310	1.22789205
35	RNA polymerase_Homo sapiens_hsa03020	1.22134907
36	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.20245380
37	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.17198343
38	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	1.16072439
39	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.14177945
40	Olfactory transduction_Homo sapiens_hsa04740	1.13602032
41	mTOR signaling pathway_Homo sapiens_hsa04150	1.11948431
42	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.07405190
43	mRNA surveillance pathway_Homo sapiens_hsa03015	1.07202132
44	B cell receptor signaling pathway_Homo sapiens_hsa04662	1.06487371
45	Thyroid cancer_Homo sapiens_hsa05216	1.05897253
46	Folate biosynthesis_Homo sapiens_hsa00790	1.02449370
47	HTLV-I infection_Homo sapiens_hsa05166	0.97873422
48	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.94106558
49	FoxO signaling pathway_Homo sapiens_hsa04068	0.91951744
50	Influenza A_Homo sapiens_hsa05164	0.87487585
51	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87414820
52	Phototransduction_Homo sapiens_hsa04744	0.86090533
53	TNF signaling pathway_Homo sapiens_hsa04668	0.85507230
54	Small cell lung cancer_Homo sapiens_hsa05222	0.83230986
55	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.82914791
56	Hepatitis B_Homo sapiens_hsa05161	0.77334870
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.76036804
58	Acute myeloid leukemia_Homo sapiens_hsa05221	0.75761502
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.74653735
60	Pancreatic cancer_Homo sapiens_hsa05212	0.72164389
61	Renal cell carcinoma_Homo sapiens_hsa05211	0.72020901
62	Spliceosome_Homo sapiens_hsa03040	0.69969789
63	Non-small cell lung cancer_Homo sapiens_hsa05223	0.67874977
64	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.67756648
65	ABC transporters_Homo sapiens_hsa02010	0.65083950
66	Chemokine signaling pathway_Homo sapiens_hsa04062	0.63804629
67	Colorectal cancer_Homo sapiens_hsa05210	0.59963032
68	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.58564326
69	Osteoclast differentiation_Homo sapiens_hsa04380	0.58239437
70	Gap junction_Homo sapiens_hsa04540	0.55981664
71	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.50263875
72	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.49637655
73	Endometrial cancer_Homo sapiens_hsa05213	0.46929113
74	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.44684556
75	MicroRNAs in cancer_Homo sapiens_hsa05206	0.44352495
76	Apoptosis_Homo sapiens_hsa04210	0.43266447
77	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.43055798
78	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.42057288
79	ErbB signaling pathway_Homo sapiens_hsa04012	0.41423844
80	Graft-versus-host disease_Homo sapiens_hsa05332	0.39119134
81	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.38679745
82	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.38317399
83	Ras signaling pathway_Homo sapiens_hsa04014	0.38016150
84	MAPK signaling pathway_Homo sapiens_hsa04010	0.37748508
85	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.37661688
86	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.36910694
87	Purine metabolism_Homo sapiens_hsa00230	0.36398020
88	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.36076162
89	Prolactin signaling pathway_Homo sapiens_hsa04917	0.36026190
90	Prostate cancer_Homo sapiens_hsa05215	0.33945825
91	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.29474970
92	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.28981190
93	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.28884212
94	Toxoplasmosis_Homo sapiens_hsa05145	0.26747159
95	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.25038587
96	Shigellosis_Homo sapiens_hsa05131	0.22526301
97	Morphine addiction_Homo sapiens_hsa05032	0.22432470
98	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.22134817
99	Hepatitis C_Homo sapiens_hsa05160	0.20917328
100	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.17940203

FAM172BP

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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