FAM173A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adenosine receptor signaling pathway (GO:0001973)6.28731965
2ribosomal small subunit assembly (GO:0000028)5.92339632
3cellular response to ATP (GO:0071318)5.56612360
4UV protection (GO:0009650)5.49127596
5regulation of synapse structural plasticity (GO:0051823)5.11744492
6modulation by virus of host process (GO:0019054)4.93009658
7adenine nucleotide transport (GO:0051503)4.76744033
8DNA strand renaturation (GO:0000733)4.67678357
9pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.67621863
10regulation of translational fidelity (GO:0006450)4.60064486
11DNA deamination (GO:0045006)4.59935125
12base-excision repair, AP site formation (GO:0006285)4.59498490
13protein insertion into membrane (GO:0051205)4.53830569
14regulation of skeletal muscle contraction (GO:0014819)4.45130787
15negative regulation of cell aging (GO:0090344)4.39878097
16G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.38563916
17cellular response to interferon-beta (GO:0035458)4.38011074
18negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.36347493
19modulation by symbiont of host cellular process (GO:0044068)4.35029891
20regulation of mitochondrial translation (GO:0070129)4.25572469
21protein retention in ER lumen (GO:0006621)4.21393858
22response to interferon-beta (GO:0035456)4.18349959
23protein complex biogenesis (GO:0070271)4.13835560
24proline biosynthetic process (GO:0006561)4.09830405
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.06936567
26negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.05406860
27regulation of cytokine production involved in inflammatory response (GO:1900015)4.01853751
28purine ribonucleotide transport (GO:0015868)3.95943716
29cytochrome complex assembly (GO:0017004)3.93638841
30signal peptide processing (GO:0006465)3.90704632
31pyrimidine nucleotide catabolic process (GO:0006244)3.89897344
32metallo-sulfur cluster assembly (GO:0031163)3.89270411
33iron-sulfur cluster assembly (GO:0016226)3.89270411
34mitochondrial respiratory chain complex assembly (GO:0033108)3.86940289
35purinergic nucleotide receptor signaling pathway (GO:0035590)3.86821848
36oxidative phosphorylation (GO:0006119)3.79377393
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.78711954
38deoxyribonucleotide catabolic process (GO:0009264)3.71688836
39respiratory chain complex IV assembly (GO:0008535)3.68925462
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.67887766
41NADH dehydrogenase complex assembly (GO:0010257)3.67887766
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.67887766
43purine nucleotide transport (GO:0015865)3.67646207
44deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.64033712
45rRNA modification (GO:0000154)3.63335749
46positive regulation of protein kinase C signaling (GO:0090037)3.55474086
47G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.52928970
48rRNA methylation (GO:0031167)3.52310087
49SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.51819543
50sulfur amino acid catabolic process (GO:0000098)3.51664428
51negative regulation of glycoprotein biosynthetic process (GO:0010561)3.51255169
52purine deoxyribonucleotide catabolic process (GO:0009155)3.50560924
53viral transcription (GO:0019083)3.47321926
54phosphatidylglycerol biosynthetic process (GO:0006655)3.47196509
55cotranslational protein targeting to membrane (GO:0006613)3.44607138
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.43324276
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.43324276
58purinergic receptor signaling pathway (GO:0035587)3.42667401
59protein targeting to ER (GO:0045047)3.40409597
60deoxyribose phosphate catabolic process (GO:0046386)3.39812004
61tRNA modification (GO:0006400)3.38749321
62protein carboxylation (GO:0018214)3.38712041
63peptidyl-glutamic acid carboxylation (GO:0017187)3.38712041
64nucleoside transmembrane transport (GO:1901642)3.37397467
65positive regulation of respiratory burst (GO:0060267)3.35665593
66lens fiber cell differentiation (GO:0070306)3.34318114
67protein localization to endoplasmic reticulum (GO:0070972)3.32280858
68translational termination (GO:0006415)3.27139261
69peptidyl-histidine modification (GO:0018202)3.25006128
70nucleotide salvage (GO:0043173)3.23953389
71regulation of oxidative phosphorylation (GO:0002082)3.23077799
72pseudouridine synthesis (GO:0001522)3.21957880
73meiotic chromosome segregation (GO:0045132)3.20119281
74mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.17541300
75establishment of protein localization to endoplasmic reticulum (GO:0072599)3.15464849
76GDP-mannose metabolic process (GO:0019673)3.14072951
77ATP synthesis coupled proton transport (GO:0015986)3.13953829
78energy coupled proton transport, down electrochemical gradient (GO:0015985)3.13953829
79regulation of hydrogen peroxide metabolic process (GO:0010310)3.13050292
80positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11630807
81respiratory electron transport chain (GO:0022904)3.11238253
82regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.10652429
83phospholipid scrambling (GO:0017121)3.10544794
84negative regulation of Notch signaling pathway (GO:0045746)3.10176493
85regulation of type B pancreatic cell apoptotic process (GO:2000674)3.09858407
86regulation of mammary gland epithelial cell proliferation (GO:0033599)3.09590294
87mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09499530
88sequestering of actin monomers (GO:0042989)3.08746459
89L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.08745293
90electron transport chain (GO:0022900)3.07338387
91aerobic respiration (GO:0009060)3.05799532
92translational elongation (GO:0006414)3.04627353
93regulation of protein kinase A signaling (GO:0010738)3.02779662
94response to ATP (GO:0033198)2.99728099
95pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.99046184
96regulation of beta-amyloid formation (GO:1902003)2.99004932
97regulation of respiratory burst (GO:0060263)2.98744817
98mannose metabolic process (GO:0006013)2.97012818
99antigen processing and presentation of endogenous antigen (GO:0019883)2.96900889
100sensory perception of taste (GO:0050909)2.96873236
101melanin biosynthetic process (GO:0042438)2.93784004
102regulation of metalloenzyme activity (GO:0048552)2.92357713
103negative regulation of phagocytosis (GO:0050765)2.91656821
104galactose catabolic process (GO:0019388)2.88903269
105negative regulation of glycoprotein metabolic process (GO:1903019)2.88863146
106proline metabolic process (GO:0006560)2.88345705
107pyrimidine-containing compound salvage (GO:0008655)2.87265109
108pyrimidine nucleoside salvage (GO:0043097)2.87265109
109chaperone-mediated protein transport (GO:0072321)2.85706458
110mitotic cell cycle arrest (GO:0071850)2.82713261
111inner mitochondrial membrane organization (GO:0007007)2.82689264
112respiratory burst (GO:0045730)2.82355756
113grooming behavior (GO:0007625)2.82126879
114activation of MAPKKK activity (GO:0000185)2.79305536
115positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.77711778
116viral life cycle (GO:0019058)2.77519737
117positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77336604
118antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.76722206
119cell migration in hindbrain (GO:0021535)2.75887794
120proteasome assembly (GO:0043248)2.75734679
121mast cell activation (GO:0045576)2.73572333
122negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.72580937
123negative regulation of tumor necrosis factor production (GO:0032720)2.72417969
124antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.72199584
125regulation of cholesterol biosynthetic process (GO:0045540)2.71028219
126negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.70787014
127mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.70171825
128DNA replication checkpoint (GO:0000076)2.69456996
129phospholipid efflux (GO:0033700)2.69317122
130oxaloacetate metabolic process (GO:0006107)2.68901864
131glutathione biosynthetic process (GO:0006750)2.67879097
1322-deoxyribonucleotide metabolic process (GO:0009394)2.67702391
133regulation of cell aging (GO:0090342)2.65949326
134purine-containing compound salvage (GO:0043101)2.64904223
135NADH metabolic process (GO:0006734)2.63498292
136daunorubicin metabolic process (GO:0044597)2.63202591
137polyketide metabolic process (GO:0030638)2.63202591
138doxorubicin metabolic process (GO:0044598)2.63202591
139cellular protein complex disassembly (GO:0043624)2.63024125
140negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.61823747
141positive regulation of gamma-delta T cell activation (GO:0046645)2.61067749
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.60116615
143regulation of cholesterol metabolic process (GO:0090181)2.59116861
144granulocyte differentiation (GO:0030851)2.58589168
145positive thymic T cell selection (GO:0045059)2.58024876
146melanin metabolic process (GO:0006582)2.57268011
147negative regulation of mitochondrion organization (GO:0010823)2.57012791
148nucleoside salvage (GO:0043174)2.56656439
149semaphorin-plexin signaling pathway (GO:0071526)2.56584441
150nucleoside transport (GO:0015858)2.56088012
151protein autoprocessing (GO:0016540)2.55829300
152response to UV-B (GO:0010224)2.54452322
153sialylation (GO:0097503)2.54104175
154deoxyribose phosphate biosynthetic process (GO:0046385)2.51896346
1552-deoxyribonucleotide biosynthetic process (GO:0009265)2.51896346
156ribosomal small subunit biogenesis (GO:0042274)2.51871974
157ribosomal large subunit biogenesis (GO:0042273)2.51544642
158translation (GO:0006412)2.51141767
159ribonucleoprotein complex biogenesis (GO:0022613)2.50975094
160L-methionine salvage (GO:0071267)2.49975487
161L-methionine biosynthetic process (GO:0071265)2.49975487
162amino acid salvage (GO:0043102)2.49975487
163sphingosine metabolic process (GO:0006670)2.49186351
164heme biosynthetic process (GO:0006783)2.49077223
165amino sugar catabolic process (GO:0046348)2.48435899
166regulation of cellular amide metabolic process (GO:0034248)2.47188315
167ncRNA 3-end processing (GO:0043628)2.46138659
168cellular anion homeostasis (GO:0030002)2.45931544
169positive regulation of protein homooligomerization (GO:0032464)2.45685629
170misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.45675650
171regulation of amyloid precursor protein catabolic process (GO:1902991)2.45256842
172nonribosomal peptide biosynthetic process (GO:0019184)2.43466794
173negative regulation of myeloid cell apoptotic process (GO:0033033)2.41786789
174glycoside metabolic process (GO:0016137)2.40333450
175negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.39182680
176cellular metabolic compound salvage (GO:0043094)2.38041128
177cellular response to exogenous dsRNA (GO:0071360)2.36093706
178antigen processing and presentation via MHC class Ib (GO:0002475)2.35410905
179CTP biosynthetic process (GO:0006241)2.33519157
180CTP metabolic process (GO:0046036)2.33519157
181regulation of synaptic vesicle exocytosis (GO:2000300)2.33160394
182mitochondrial calcium ion transport (GO:0006851)2.32147396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.82731032
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.37002609
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30621128
4E2F7_22180533_ChIP-Seq_HELA_Human3.19408277
5* FLI1_20887958_ChIP-Seq_HPC-7_Mouse3.06624652
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92781603
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.90651097
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87122705
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86347222
10SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.70691480
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.67548631
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63851223
13P68_20966046_ChIP-Seq_HELA_Human2.55744098
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.51410895
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.42457694
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.37685324
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.31755573
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28131723
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.20752686
20SRF_21415370_ChIP-Seq_HL-1_Mouse2.18597204
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18534582
22SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.14337405
23* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14221070
24GATA1_22025678_ChIP-Seq_K562_Human2.13449842
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.13180035
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12555138
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06300064
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.05628311
29IRF8_21731497_ChIP-ChIP_J774_Mouse2.04058159
30MYC_18358816_ChIP-ChIP_MESCs_Mouse1.99331017
31DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.97725517
32MYC_22102868_ChIP-Seq_BL_Human1.96860448
33RACK7_27058665_Chip-Seq_MCF-7_Human1.96849514
34BCOR_27268052_Chip-Seq_Bcells_Human1.92217138
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89191644
36CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.88525992
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.88027559
38ELF1_20517297_ChIP-Seq_JURKAT_Human1.86639262
39* MAF_26560356_Chip-Seq_TH2_Human1.86357775
40EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.85879299
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.85429709
42VDR_23849224_ChIP-Seq_CD4+_Human1.84694537
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82619848
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.79840144
45MYC_18555785_ChIP-Seq_MESCs_Mouse1.79338712
46CTCF_27219007_Chip-Seq_Bcells_Human1.78314923
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.76763651
48* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76458112
49E2F1_20622854_ChIP-Seq_HELA_Human1.76094228
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75408327
51* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.74999819
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74452141
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73490206
54CTCF_27219007_Chip-Seq_ERYTHROID_Human1.73009751
55STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71827594
56FOXP3_21729870_ChIP-Seq_TREG_Human1.71494863
57CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70060948
58SPI1_23547873_ChIP-Seq_NB4_Human1.69349148
59PHF8_20622854_ChIP-Seq_HELA_Human1.69316654
60THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67259745
61* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.66147946
62DCP1A_22483619_ChIP-Seq_HELA_Human1.64389483
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.64178446
64VDR_21846776_ChIP-Seq_THP-1_Human1.62610915
65* FOXP1_21924763_ChIP-Seq_HESCs_Human1.62476864
66* SMC4_20622854_ChIP-Seq_HELA_Human1.60545582
67SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.60505333
68* KDM2B_26808549_Chip-Seq_DND41_Human1.59694292
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58367713
70CTCF_18555785_ChIP-Seq_MESCs_Mouse1.57984451
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.56209717
72XRN2_22483619_ChIP-Seq_HELA_Human1.54688860
73* GABP_19822575_ChIP-Seq_HepG2_Human1.53894993
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.53215847
75CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53154396
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52719156
77BP1_19119308_ChIP-ChIP_Hs578T_Human1.52560403
78RARB_24833708_ChIP-Seq_LIVER_Mouse1.52282983
79E2F1_18555785_ChIP-Seq_MESCs_Mouse1.50982427
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.47313999
81* MAF_26560356_Chip-Seq_TH1_Human1.45888157
82CTCF_21964334_Chip-Seq_Bcells_Human1.44710444
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.44179231
84CTCF_20526341_ChIP-Seq_ESCs_Human1.42335333
85BCL6_27268052_Chip-Seq_Bcells_Human1.41914739
86RARA_24833708_ChIP-Seq_LIVER_Mouse1.41851799
87SA1_27219007_Chip-Seq_Bcells_Human1.41367550
88EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40476532
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.36832225
90DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34546970
91CTCF_21964334_ChIP-Seq_BJAB-B_Human1.32056368
92VDR_24763502_ChIP-Seq_THP-1_Human1.31541576
93UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31514700
94PU.1_20513432_ChIP-Seq_Bcells_Mouse1.30904460
95UTX_26944678_Chip-Seq_JUKART_Human1.30562226
96* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30157292
97CREB1_26743006_Chip-Seq_LNCaP_Human1.29809684
98TP53_22127205_ChIP-Seq_IMR90_Human1.29394875
99ZNF263_19887448_ChIP-Seq_K562_Human1.28943914
100SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.28057211
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26841150
102CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.26770412
103GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25289577
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25208793
105RXRA_24833708_ChIP-Seq_LIVER_Mouse1.25207073
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.25128737
107CIITA_25753668_ChIP-Seq_RAJI_Human1.24765492
108* TET1_21451524_ChIP-Seq_MESCs_Mouse1.23152001
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22869493
110MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21834719
111SCL_19346495_ChIP-Seq_HPC-7_Human1.21662699
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21358666
113SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20548124
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.20190455
115TCF7_22412390_ChIP-Seq_EML_Mouse1.19684644
116ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.19436904
117* ETS1_21867929_ChIP-Seq_TH2_Mouse1.17944897
118CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17431318
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17225197
120PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17213041
121FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.16673002
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16507155
123E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16459346
124RUNX1_22412390_ChIP-Seq_EML_Mouse1.16413069
125SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.15338955
126SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14873245
127ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14865474
128RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14217812
129PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13144447
130KDM2B_26808549_Chip-Seq_K562_Human1.12986375
131SMC3_22415368_ChIP-Seq_MEFs_Mouse1.11418722
132IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11311883
133GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09693265
134SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09042511
135CTCF_26484167_Chip-Seq_Bcells_Mouse1.08642555
136YY1_22570637_ChIP-Seq_MALME-3M_Human1.08088430
137GATA3_21867929_ChIP-Seq_CD8_Mouse1.07453717
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06791063
139* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06564523
140SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06323945
141E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06051619
142NCOR1_26117541_ChIP-Seq_K562_Human1.05775915
143SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05620658
144MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04998370
145ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03992972
146* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.03952243
147MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.03765681
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03267595
149BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.02342768
150EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00240826
151TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99754113
152LXR_22292898_ChIP-Seq_THP-1_Human0.99593577
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99268378
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98809499
155ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97733439

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation5.49834533
2MP0005423_abnormal_somatic_nervous4.60748985
3MP0003136_yellow_coat_color3.50244757
4MP0001835_abnormal_antigen_presentation3.28106136
5MP0005671_abnormal_response_to2.84094324
6MP0003011_delayed_dark_adaptation2.83267593
7MP0000750_abnormal_muscle_regeneration2.79862133
8MP0000685_abnormal_immune_system2.74491458
9MP0001188_hyperpigmentation2.54843672
10MP0009785_altered_susceptibility_to2.49677566
11MP0009379_abnormal_foot_pigmentation2.47105903
12MP0003724_increased_susceptibility_to2.34878053
13MP0002148_abnormal_hypersensitivity_rea2.22918799
14MP0005409_darkened_coat_color2.18712826
15MP0000015_abnormal_ear_pigmentation2.17109836
16MP0003303_peritoneal_inflammation2.14625812
17MP0006036_abnormal_mitochondrial_physio2.13654302
18MP0003763_abnormal_thymus_physiology2.13604525
19MP0001502_abnormal_circadian_rhythm2.07827545
20MP0002876_abnormal_thyroid_physiology2.06620196
21MP0003186_abnormal_redox_activity2.05692617
22MP0005025_abnormal_response_to2.04471291
23MP0004858_abnormal_nervous_system1.99855075
24MP0000751_myopathy1.99723246
25MP0001986_abnormal_taste_sensitivity1.99296033
26MP0001756_abnormal_urination1.97580015
27MP0003806_abnormal_nucleotide_metabolis1.96431415
28MP0005000_abnormal_immune_tolerance1.96124760
29MP0003436_decreased_susceptibility_to1.93908026
30MP0001661_extended_life_span1.90840219
31MP0005058_abnormal_lysosome_morphology1.86881975
32MP0002419_abnormal_innate_immunity1.82260683
33MP0001790_abnormal_immune_system1.81990009
34MP0005387_immune_system_phenotype1.81990009
35MP0001764_abnormal_homeostasis1.80195821
36MP0003705_abnormal_hypodermis_morpholog1.77132873
37MP0005330_cardiomyopathy1.74523494
38MP0003693_abnormal_embryo_hatching1.73877076
39MP0002420_abnormal_adaptive_immunity1.71968707
40MP0002723_abnormal_immune_serum1.70060147
41MP0004130_abnormal_muscle_cell1.69719459
42MP0001819_abnormal_immune_cell1.69596061
43MP0003453_abnormal_keratinocyte_physiol1.69132066
44MP0005220_abnormal_exocrine_pancreas1.66169599
45MP0001800_abnormal_humoral_immune1.66106100
46MP0000538_abnormal_urinary_bladder1.61242368
47MP0002736_abnormal_nociception_after1.59999317
48MP0002396_abnormal_hematopoietic_system1.59321888
49MP0002452_abnormal_antigen_presenting1.59020137
50MP0005464_abnormal_platelet_physiology1.57537135
51MP0004381_abnormal_hair_follicle1.57338998
52MP0002132_abnormal_respiratory_system1.54107158
53MP0008875_abnormal_xenobiotic_pharmacok1.50108944
54MP0004043_abnormal_pH_regulation1.49798558
55MP0000858_altered_metastatic_potential1.48463557
56MP0003866_abnormal_defecation1.45438671
57MP0001270_distended_abdomen1.44472025
58MP0002638_abnormal_pupillary_reflex1.43574826
59MP0000747_muscle_weakness1.41924508
60MP0002398_abnormal_bone_marrow1.41842521
61MP0000003_abnormal_adipose_tissue1.41181702
62MP0000465_gastrointestinal_hemorrhage1.39261323
63MP0001545_abnormal_hematopoietic_system1.38545845
64MP0005397_hematopoietic_system_phenotyp1.38545845
65MP0006035_abnormal_mitochondrial_morpho1.38500334
66MP0002405_respiratory_system_inflammati1.38094821
67MP0000716_abnormal_immune_system1.37898376
68MP0003329_amyloid_beta_deposits1.37254867
69MP0003879_abnormal_hair_cell1.36652137
70MP0001845_abnormal_inflammatory_respons1.36498511
71MP0004859_abnormal_synaptic_plasticity1.35957298
72MP0008469_abnormal_protein_level1.35045057
73MP0000013_abnormal_adipose_tissue1.34722681
74MP0002909_abnormal_adrenal_gland1.33605349
75MP0001905_abnormal_dopamine_level1.32513093
76MP0003137_abnormal_impulse_conducting1.32454296
77MP0003191_abnormal_cellular_cholesterol1.32200241
78MP0000689_abnormal_spleen_morphology1.32099370
79MP0002139_abnormal_hepatobiliary_system1.30433804
80MP0001663_abnormal_digestive_system1.29892349
81MP0010329_abnormal_lipoprotein_level1.28319780
82MP0002693_abnormal_pancreas_physiology1.28027880
83MP0005075_abnormal_melanosome_morpholog1.27497365
84MP0001853_heart_inflammation1.26910366
85MP0003880_abnormal_central_pattern1.26152608
86MP0005636_abnormal_mineral_homeostasis1.24720759
87MP0001968_abnormal_touch/_nociception1.23354988
88MP0005584_abnormal_enzyme/coenzyme_acti1.22062801
89MP0002722_abnormal_immune_system1.22060115
90MP0005451_abnormal_body_composition1.20943562
91MP0010155_abnormal_intestine_physiology1.20896568
92MP0003183_abnormal_peptide_metabolism1.20659126
93MP0009840_abnormal_foam_cell1.19822238
94MP0005365_abnormal_bile_salt1.18799390
95MP0002429_abnormal_blood_cell1.18595761
96MP0009278_abnormal_bone_marrow1.18373900
97MP0001984_abnormal_olfaction1.18224268
98MP0005501_abnormal_skin_physiology1.17944718
99MP0001348_abnormal_lacrimal_gland1.17385108
100MP0001873_stomach_inflammation1.16978934
101MP0002160_abnormal_reproductive_system1.13831619
102MP0009333_abnormal_splenocyte_physiolog1.13017118
103MP0005379_endocrine/exocrine_gland_phen1.10978936
104MP0001664_abnormal_digestion1.10831901
105MP0002166_altered_tumor_susceptibility1.10369618
106MP0008260_abnormal_autophagy1.09612012
107MP0000604_amyloidosis1.05470527
108MP0000678_abnormal_parathyroid_gland1.04266311
109MP0005645_abnormal_hypothalamus_physiol1.02522260
110MP0004782_abnormal_surfactant_physiolog1.02418435
111MP0002735_abnormal_chemical_nociception1.02244542
112MP0005310_abnormal_salivary_gland1.02080576
113MP0002733_abnormal_thermal_nociception1.01181025
114MP0008872_abnormal_physiological_respon0.99289103
115MP0000343_altered_response_to0.98448528
116MP0006082_CNS_inflammation0.97908921
117MP0003786_premature_aging0.96757044
118MP0002249_abnormal_larynx_morphology0.95951471
119MP0000681_abnormal_thyroid_gland0.95891829
120MP0003111_abnormal_nucleus_morphology0.95373063
121MP0000358_abnormal_cell_content/0.92953637
122MP0002006_tumorigenesis0.91783319
123MP0009643_abnormal_urine_homeostasis0.90678245
124MP0009764_decreased_sensitivity_to0.89970004
125MP0004185_abnormal_adipocyte_glucose0.89656019
126MP0004808_abnormal_hematopoietic_stem0.89125026
127MP0005084_abnormal_gallbladder_morpholo0.88705070
128MP0003656_abnormal_erythrocyte_physiolo0.87867421
129MP0003646_muscle_fatigue0.87731886
130MP0005083_abnormal_biliary_tract0.87659946
131MP0001919_abnormal_reproductive_system0.87299845
132MP0005332_abnormal_amino_acid0.86657603
133MP0003172_abnormal_lysosome_physiology0.86360361
134MP0004147_increased_porphyrin_level0.86019181
135MP0000367_abnormal_coat/_hair0.84468257
136MP0009745_abnormal_behavioral_response0.84428913
137MP0005174_abnormal_tail_pigmentation0.83061486
138MP0008874_decreased_physiological_sensi0.82968328
139MP0004142_abnormal_muscle_tone0.82947712
140MP0002089_abnormal_postnatal_growth/wei0.82487270
141MP0005375_adipose_tissue_phenotype0.82330540
142MP0004019_abnormal_vitamin_homeostasis0.81713299
143MP0000372_irregular_coat_pigmentation0.81633175
144MP0005381_digestive/alimentary_phenotyp0.81449302
145MP0008789_abnormal_olfactory_epithelium0.81381233
146MP0000703_abnormal_thymus_morphology0.80972090
147MP0006292_abnormal_olfactory_placode0.80810649
148MP0005410_abnormal_fertilization0.80755083
149MP0005623_abnormal_meninges_morphology0.80590394
150MP0001958_emphysema0.80023927
151MP0001765_abnormal_ion_homeostasis0.78217726
152MP0009384_cardiac_valve_regurgitation0.76930851
153MP0001970_abnormal_pain_threshold0.75042098
154MP0003635_abnormal_synaptic_transmissio0.66104030
155MP0005257_abnormal_intraocular_pressure0.64493384
156MP0009931_abnormal_skin_appearance0.64004038
157MP0002653_abnormal_ependyma_morphology0.62403123
158MP0005076_abnormal_cell_differentiation0.61587495
159MP0005551_abnormal_eye_electrophysiolog0.59883736
160MP0000470_abnormal_stomach_morphology0.58883827
161MP0003123_paternal_imprinting0.58834449
162MP0000490_abnormal_crypts_of0.58658097
163MP0000759_abnormal_skeletal_muscle0.58528594
164MP0005666_abnormal_adipose_tissue0.57753769
165MP0004947_skin_inflammation0.57061780
166MP0003448_altered_tumor_morphology0.54686495
167MP0002075_abnormal_coat/hair_pigmentati0.53918141
168MP0002933_joint_inflammation0.53204970
169MP0002063_abnormal_learning/memory/cond0.52591493
170MP0002019_abnormal_tumor_incidence0.52235062

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)6.27881121
2Rib fusion (HP:0000902)5.18417890
3Large eyes (HP:0001090)4.52763946
4Ulnar bowing (HP:0003031)4.29088938
5Annular pancreas (HP:0001734)4.28470095
6Poikiloderma (HP:0001029)4.27580515
7Acute necrotizing encephalopathy (HP:0006965)4.25313523
8Abnormal mitochondria in muscle tissue (HP:0008316)4.17485666
9Thin bony cortex (HP:0002753)4.07317501
10Mitochondrial inheritance (HP:0001427)3.80803660
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.76908614
12Hepatocellular necrosis (HP:0001404)3.68305435
13Vaginal fistula (HP:0004320)3.66399401
14Mesangial abnormality (HP:0001966)3.65908113
15Acute encephalopathy (HP:0006846)3.63521656
16Turricephaly (HP:0000262)3.59302324
17Microretrognathia (HP:0000308)3.57849080
18Hepatic necrosis (HP:0002605)3.57255020
19Rectovaginal fistula (HP:0000143)3.56578319
20Rectal fistula (HP:0100590)3.56578319
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.47346418
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47290918
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47290918
24Akinesia (HP:0002304)3.42016678
25Progressive macrocephaly (HP:0004481)3.38396613
26Increased CSF lactate (HP:0002490)3.34580963
27Ragged-red muscle fibers (HP:0003200)3.30553261
28Recurrent abscess formation (HP:0002722)3.30278935
29Intestinal fistula (HP:0100819)3.24795441
30Dyschromatopsia (HP:0007641)3.23662615
31Squamous cell carcinoma (HP:0002860)3.23408416
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.22368975
33Aplastic anemia (HP:0001915)3.20022743
34Reduced antithrombin III activity (HP:0001976)3.11705286
35Fetal akinesia sequence (HP:0001989)3.09643971
36Type I transferrin isoform profile (HP:0003642)3.06529693
37Decreased electroretinogram (ERG) amplitude (HP:0000654)3.03426508
38Facial hemangioma (HP:0000329)3.00156782
39Hemorrhage of the eye (HP:0011885)2.96098776
40Vacuolated lymphocytes (HP:0001922)2.95824096
41Chronic otitis media (HP:0000389)2.95136035
42Petechiae (HP:0000967)2.93554999
43Delayed epiphyseal ossification (HP:0002663)2.92000413
44Esophageal neoplasm (HP:0100751)2.90505175
45Neoplasm of head and neck (HP:0012288)2.90505175
46Abnormal number of erythroid precursors (HP:0012131)2.89596645
47Nasal polyposis (HP:0100582)2.89396514
48Recurrent bacterial skin infections (HP:0005406)2.84616019
49Patent foramen ovale (HP:0001655)2.84241469
50Elevated erythrocyte sedimentation rate (HP:0003565)2.83856294
51Joint stiffness (HP:0001387)2.83774310
52Thrombocytosis (HP:0001894)2.82954564
53Abnormality of cells of the erythroid lineage (HP:0012130)2.79595867
54Hypoplasia of the thymus (HP:0000778)2.79114208
55IgM deficiency (HP:0002850)2.77754967
56Broad distal phalanx of finger (HP:0009836)2.77323122
57Myopathic facies (HP:0002058)2.75926834
58Aplasia of the musculature (HP:0100854)2.74845743
59Generalized aminoaciduria (HP:0002909)2.68695492
60Lactic acidosis (HP:0003128)2.68327856
61Attenuation of retinal blood vessels (HP:0007843)2.67492483
62Progressive external ophthalmoplegia (HP:0000590)2.61874467
63Bowed forearm bones (HP:0003956)2.59244853
64Bowing of the arm (HP:0006488)2.59244853
65Abnormal protein glycosylation (HP:0012346)2.58515496
66Abnormal glycosylation (HP:0012345)2.58515496
67Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58515496
68Abnormal protein N-linked glycosylation (HP:0012347)2.58515496
69Cerebral edema (HP:0002181)2.55741073
70Facial diplegia (HP:0001349)2.55707475
71Cerebral palsy (HP:0100021)2.54334464
72Hypothermia (HP:0002045)2.54096157
73Hypochromic anemia (HP:0001931)2.48209933
74Gastrointestinal infarctions (HP:0005244)2.46332409
75Increased serum lactate (HP:0002151)2.45473490
76Popliteal pterygium (HP:0009756)2.44880504
77Patellar aplasia (HP:0006443)2.44838183
78Aplasia/Hypoplasia of the patella (HP:0006498)2.44822536
79Eczematoid dermatitis (HP:0000976)2.43327911
80Abnormality of the nasal mucosa (HP:0000433)2.41644271
81Neonatal onset (HP:0003623)2.40821009
82Panhypogammaglobulinemia (HP:0003139)2.38356435
83Congenital stationary night blindness (HP:0007642)2.35195633
84Dysostosis multiplex (HP:0000943)2.35057007
85Myotonia (HP:0002486)2.30758483
86Abnormality of aromatic amino acid family metabolism (HP:0004338)2.30557334
873-Methylglutaconic aciduria (HP:0003535)2.29926283
88Axonal loss (HP:0003447)2.27802268
89Premature graying of hair (HP:0002216)2.27556917
90Coronal craniosynostosis (HP:0004440)2.26800590
91Diminished movement (HP:0002374)2.26454656
92Absent thumb (HP:0009777)2.24376464
93Abnormality of the intrinsic pathway (HP:0010989)2.20792364
94Reticulocytopenia (HP:0001896)2.19380860
95Choanal stenosis (HP:0000452)2.17915826
96Exercise intolerance (HP:0003546)2.17770187
97Respiratory failure (HP:0002878)2.14474008
98Recurrent skin infections (HP:0001581)2.13933484
99Increased intramyocellular lipid droplets (HP:0012240)2.13251157
100Abnormality of glycolipid metabolism (HP:0010969)2.11718716
101Abnormality of liposaccharide metabolism (HP:0010968)2.11718716
102Abnormality of glycosphingolipid metabolism (HP:0004343)2.11718716
103Hypoalbuminemia (HP:0003073)2.11441777
104Abnormal albumin level (HP:0012116)2.11441777
105Anteriorly placed anus (HP:0001545)2.11139630
106Optic disc pallor (HP:0000543)2.10779208
107Increased muscle lipid content (HP:0009058)2.10767760
108Joint hemorrhage (HP:0005261)2.10611307
109Recurrent gram-negative bacterial infections (HP:0005420)2.10233413
110Amniotic constriction ring (HP:0009775)2.10145701
111Abnormality of placental membranes (HP:0011409)2.10145701
112Dry hair (HP:0011359)2.10065353
113Abnormality of the costochondral junction (HP:0000919)2.09874456
114B lymphocytopenia (HP:0010976)2.08583174
115Abnormality of B cell number (HP:0010975)2.08583174
116Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.07150656
117Prolonged bleeding time (HP:0003010)2.06134379
118Chronic mucocutaneous candidiasis (HP:0002728)2.05351673
119Recurrent cutaneous fungal infections (HP:0011370)2.05351673
120Urinary glycosaminoglycan excretion (HP:0003541)2.04954232
121Mucopolysacchariduria (HP:0008155)2.04954232
122External ophthalmoplegia (HP:0000544)2.02941121
123Rectal prolapse (HP:0002035)1.99253445
124Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98541186
125Meningitis (HP:0001287)1.98370031
126Progressive microcephaly (HP:0000253)1.98305435
127Retinal dysplasia (HP:0007973)1.97574156
128Abnormality of macrophages (HP:0004311)1.97536875
129Male infertility (HP:0003251)1.97217277
130Neutropenia (HP:0001875)1.94666596
131Hypoplasia of the pons (HP:0012110)1.93347822
132Short chin (HP:0000331)1.92459443
133Poor suck (HP:0002033)1.90741637
134Esotropia (HP:0000565)1.89870519
135Recurrent bronchitis (HP:0002837)1.89429346
136Exertional dyspnea (HP:0002875)1.89031668
137Cholelithiasis (HP:0001081)1.86745268
138Retinal atrophy (HP:0001105)1.86248271
139Dicarboxylic aciduria (HP:0003215)1.86159059
140Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86159059
141Recurrent fungal infections (HP:0002841)1.85487612
142Atrioventricular block (HP:0001678)1.84637331
143Abnormal epiphyseal ossification (HP:0010656)1.84143726
144Lethargy (HP:0001254)1.83994430
145Agammaglobulinemia (HP:0004432)1.83612712
146Systemic lupus erythematosus (HP:0002725)1.83279329
147Lipid accumulation in hepatocytes (HP:0006561)1.83090917
148Renal Fanconi syndrome (HP:0001994)1.82750195
149Bony spicule pigmentary retinopathy (HP:0007737)1.81873211
150Progressive neurologic deterioration (HP:0002344)1.81818499
151Hypophosphatemic rickets (HP:0004912)1.81289829
152Purpura (HP:0000979)1.81236324
153Abnormality of T cell physiology (HP:0011840)1.80888801
154Abnormal delayed hypersensitivity skin test (HP:0002963)1.79531992
155Abnormal urine phosphate concentration (HP:0012599)1.78194616
156Pancytopenia (HP:0001876)1.77941086
157Abnormality of polysaccharide metabolism (HP:0011012)1.77656449
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77656449
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77656449
160Breast hypoplasia (HP:0003187)1.77500920
161Increased hepatocellular lipid droplets (HP:0006565)1.76132680
162Macrocytic anemia (HP:0001972)1.76100742
163Hypertensive crisis (HP:0100735)1.75809840
164Muscle fiber atrophy (HP:0100295)1.75761956
165Abnormal trabecular bone morphology (HP:0100671)1.75316079
166Chronic sinusitis (HP:0011109)1.75217148
167Widely patent fontanelles and sutures (HP:0004492)1.75167664
168Opisthotonus (HP:0002179)1.74914046
169Mediastinal lymphadenopathy (HP:0100721)1.74578424
170Chorioretinal atrophy (HP:0000533)1.74515568
171Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74303296
172Obstructive lung disease (HP:0006536)1.73083711
173Chronic obstructive pulmonary disease (HP:0006510)1.73083711
174CNS demyelination (HP:0007305)1.72664513
175Microvesicular hepatic steatosis (HP:0001414)1.71816594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.21757266
2STK163.86318212
3TRIB33.61067634
4CDK193.18824736
5NME22.88928844
6SIK22.55093295
7BCKDK2.37157158
8TXK2.21027240
9SIK12.16973600
10LIMK12.16383454
11MAP2K72.15898683
12TNIK2.12988117
13MAP4K11.94037968
14IRAK41.93220586
15WNK41.88289787
16NME11.84479230
17KIT1.83520923
18TEC1.79565224
19MAP3K21.72807038
20MYLK1.68224009
21ZAP701.65599833
22BLK1.61183250
23TBK11.57571738
24MUSK1.55998059
25ACVR1B1.55539866
26EIF2AK31.54658227
27RIPK41.47509994
28MAPKAPK31.47262252
29BTK1.45621683
30IKBKE1.45292336
31DAPK11.39529294
32SIK31.36260380
33PIM21.35103102
34KDR1.32160958
35LMTK21.31664122
36SYK1.27841941
37PKN21.23620064
38RPS6KA41.23436926
39CASK1.22438864
40ARAF1.22042599
41TYK21.21581137
42TAOK21.20889734
43FLT31.20700642
44MAPK121.16862803
45BUB11.16044437
46VRK11.12709185
47TLK11.12420106
48MAP3K141.11469753
49FES1.09742230
50IRAK21.08501702
51CAMKK21.08183743
52PDPK11.07750913
53CCNB11.07669374
54PRKD31.05788529
55CDK11A1.05033521
56PRPF4B1.03433732
57PRKD21.02907821
58PIK3CG1.02829904
59AURKA1.02773993
60SMG11.02638888
61CDK151.01835154
62IRAK31.01819361
63CDC42BPA1.00836820
64CAMKK11.00241513
65CSF1R0.99989445
66ADRBK20.98132079
67MAP3K110.96053959
68MST40.95695516
69MAP2K20.95656262
70EEF2K0.94341922
71TNK20.92027324
72CDK180.91581163
73NLK0.89242969
74PASK0.88939736
75LYN0.88473214
76RPS6KA20.88094750
77GRK70.87855282
78TSSK60.87535130
79MAPK110.86508762
80CDK140.83364759
81CAMK10.82675844
82PINK10.82125027
83ICK0.81920826
84NEK20.81090124
85BMPR20.80828710
86MAP2K40.79379429
87MAPKAPK50.78791126
88EPHA20.77597605
89DYRK1B0.77239399
90CDK80.76611606
91PAK10.75044436
92MAP2K60.74470364
93DAPK30.72881085
94PDK20.71617210
95PRKG20.70557488
96INSRR0.69937013
97MAP3K100.69869768
98CDK40.68108981
99BRAF0.67330040
100SCYL20.66434755
101MARK20.65391607
102ZAK0.65330557
103ILK0.64061931
104EIF2AK10.63489049
105ERN10.61369903
106TGFBR20.61220006
107GRK60.59781580
108STK110.58661895
109CSNK1G30.58274850
110RPS6KA50.57744982
111LCK0.57443507
112RPS6KB10.56753830
113RPS6KA60.56324929
114JAK30.54043507
115MARK30.53906720
116LRRK20.53639209
117PRKD10.53625330
118TTN0.53442912
119RPS6KL10.53162189
120RPS6KC10.53162189
121CLK10.52704692
122BMX0.51585668
123TESK20.51427959
124PAK60.49714181
125YES10.49169366
126ADRBK10.48967756
127DYRK20.48455790
128BRSK10.48218570
129PRKCQ0.47439731
130IKBKB0.46429543
131JAK10.45612861
132DAPK20.45016650
133PTK60.44957747
134AKT20.44902318
135PRKCD0.43769673
136MAPK40.42370503
137NTRK10.42234316
138TAOK30.41307279
139RPS6KB20.40938775
140CAMK2G0.40849215
141MAP3K130.40765914
142CSNK1A1L0.39242776
143TESK10.38758066
144PRKCI0.38367064
145CSK0.37816835
146PAK40.37324917
147EPHB20.37251779
148ABL20.34559830
149MAP3K10.33608685
150IRAK10.31358685
151MAPK150.31305370
152CSNK2A10.31125142
153MINK10.28989708
154MAP2K30.28579368
155MAPK130.28565931
156JAK20.27657246

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.00662249
2Oxidative phosphorylation_Homo sapiens_hsa001903.56575390
3Parkinsons disease_Homo sapiens_hsa050122.96480132
4Protein export_Homo sapiens_hsa030602.86994953
5Proteasome_Homo sapiens_hsa030502.67629021
6Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.45536829
7Other glycan degradation_Homo sapiens_hsa005112.40168328
8Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.37056727
9Primary immunodeficiency_Homo sapiens_hsa053402.14807918
10DNA replication_Homo sapiens_hsa030302.09837290
11Alzheimers disease_Homo sapiens_hsa050102.04581654
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.92190000
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.89388261
14Caffeine metabolism_Homo sapiens_hsa002321.84662744
15Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81078976
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.80635354
17Huntingtons disease_Homo sapiens_hsa050161.75483185
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.74947214
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.68335548
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65838746
21Pyrimidine metabolism_Homo sapiens_hsa002401.65746334
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56036228
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55746664
24Collecting duct acid secretion_Homo sapiens_hsa049661.53519968
25Pentose phosphate pathway_Homo sapiens_hsa000301.52706271
26Folate biosynthesis_Homo sapiens_hsa007901.51665767
27Galactose metabolism_Homo sapiens_hsa000521.44510313
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.44369662
29Sulfur relay system_Homo sapiens_hsa041221.42172460
30Mismatch repair_Homo sapiens_hsa034301.41507815
31Sphingolipid metabolism_Homo sapiens_hsa006001.39831607
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38860391
33Drug metabolism - other enzymes_Homo sapiens_hsa009831.38424308
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.32106982
35Sulfur metabolism_Homo sapiens_hsa009201.30395571
36Base excision repair_Homo sapiens_hsa034101.28675932
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.17425925
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.17211216
39Synaptic vesicle cycle_Homo sapiens_hsa047211.15974052
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.11851499
41Fructose and mannose metabolism_Homo sapiens_hsa000511.09561897
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09418638
43N-Glycan biosynthesis_Homo sapiens_hsa005101.07748977
44Nucleotide excision repair_Homo sapiens_hsa034201.07217433
45Vitamin B6 metabolism_Homo sapiens_hsa007501.06184265
46Vibrio cholerae infection_Homo sapiens_hsa051101.05518462
47Hematopoietic cell lineage_Homo sapiens_hsa046401.05415532
48Antigen processing and presentation_Homo sapiens_hsa046121.03198757
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03075621
50RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01116870
51Fanconi anemia pathway_Homo sapiens_hsa034600.99652564
52Lysosome_Homo sapiens_hsa041420.97913390
53RNA polymerase_Homo sapiens_hsa030200.96826720
54Asthma_Homo sapiens_hsa053100.96057884
55Regulation of autophagy_Homo sapiens_hsa041400.95617291
56Bladder cancer_Homo sapiens_hsa052190.95439292
57ABC transporters_Homo sapiens_hsa020100.94776276
58Peroxisome_Homo sapiens_hsa041460.94121252
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.92365617
60VEGF signaling pathway_Homo sapiens_hsa043700.92227806
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92145750
62Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91153060
63Leishmaniasis_Homo sapiens_hsa051400.91114194
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90498338
65Legionellosis_Homo sapiens_hsa051340.89447451
66Rheumatoid arthritis_Homo sapiens_hsa053230.89160180
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88324763
68Pyruvate metabolism_Homo sapiens_hsa006200.86621332
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.85719205
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83735356
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.83455893
72Phenylalanine metabolism_Homo sapiens_hsa003600.80077779
73Homologous recombination_Homo sapiens_hsa034400.77224882
74Purine metabolism_Homo sapiens_hsa002300.76164441
75Alcoholism_Homo sapiens_hsa050340.74051806
76Staphylococcus aureus infection_Homo sapiens_hsa051500.73835312
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.73220503
78Metabolic pathways_Homo sapiens_hsa011000.72141030
79Chemical carcinogenesis_Homo sapiens_hsa052040.71977977
80Type I diabetes mellitus_Homo sapiens_hsa049400.69978929
81Notch signaling pathway_Homo sapiens_hsa043300.68232829
82Nicotine addiction_Homo sapiens_hsa050330.68097279
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67733752
84Carbon metabolism_Homo sapiens_hsa012000.67341293
85Starch and sucrose metabolism_Homo sapiens_hsa005000.65212452
86Allograft rejection_Homo sapiens_hsa053300.64539727
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.63643385
88Arginine biosynthesis_Homo sapiens_hsa002200.63592279
89Pertussis_Homo sapiens_hsa051330.63106325
90beta-Alanine metabolism_Homo sapiens_hsa004100.63044373
91Measles_Homo sapiens_hsa051620.59830019
92Biosynthesis of amino acids_Homo sapiens_hsa012300.57245305
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.54927353
94Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52226326
95Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50773342
96Cardiac muscle contraction_Homo sapiens_hsa042600.50696517
97Systemic lupus erythematosus_Homo sapiens_hsa053220.50232577
98Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49296407
99Selenocompound metabolism_Homo sapiens_hsa004500.48811274
100Endocytosis_Homo sapiens_hsa041440.47747526
101African trypanosomiasis_Homo sapiens_hsa051430.47503928
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.47123713
103Phagosome_Homo sapiens_hsa041450.45151992
104Glutathione metabolism_Homo sapiens_hsa004800.44709750
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44676712
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44562118
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44037757
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44032706
109Histidine metabolism_Homo sapiens_hsa003400.43149723
110Spliceosome_Homo sapiens_hsa030400.41287114
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41194318
112Arginine and proline metabolism_Homo sapiens_hsa003300.40307244
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36888087
114Non-homologous end-joining_Homo sapiens_hsa034500.36753540
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36579891
116Insulin secretion_Homo sapiens_hsa049110.36522126
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.36475207
118Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.36461766
119Cocaine addiction_Homo sapiens_hsa050300.36222637
120Hedgehog signaling pathway_Homo sapiens_hsa043400.35705738
121Renin-angiotensin system_Homo sapiens_hsa046140.35171112
122Tuberculosis_Homo sapiens_hsa051520.35035727
123Apoptosis_Homo sapiens_hsa042100.34526536
124Arachidonic acid metabolism_Homo sapiens_hsa005900.33798112
125Cyanoamino acid metabolism_Homo sapiens_hsa004600.33647654
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33300178
127Fatty acid degradation_Homo sapiens_hsa000710.32958597
128Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.32530491
129Prion diseases_Homo sapiens_hsa050200.32170921
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32023759
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31496286
132mTOR signaling pathway_Homo sapiens_hsa041500.29207561
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.27032346
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.26685241
135Salmonella infection_Homo sapiens_hsa051320.26622011
136Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20486955
137Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17609540
138Hepatitis C_Homo sapiens_hsa051600.16721860
139Vitamin digestion and absorption_Homo sapiens_hsa049770.16563199
140Osteoclast differentiation_Homo sapiens_hsa043800.14819141
141Tyrosine metabolism_Homo sapiens_hsa003500.14742987
142Shigellosis_Homo sapiens_hsa051310.13983184
143Inositol phosphate metabolism_Homo sapiens_hsa005620.13687787
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.13457861
145PPAR signaling pathway_Homo sapiens_hsa033200.11801756
146Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.11277363
147Acute myeloid leukemia_Homo sapiens_hsa052210.10705346
148Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.10407318
149Calcium signaling pathway_Homo sapiens_hsa040200.09598844

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