FAM173B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)7.96772320
2central nervous system myelination (GO:0022010)7.96772320
3fatty acid elongation (GO:0030497)6.26133704
4presynaptic membrane assembly (GO:0097105)5.25530044
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.11594659
6glycerophospholipid catabolic process (GO:0046475)4.90852954
7myelination (GO:0042552)4.88721990
8long-chain fatty acid biosynthetic process (GO:0042759)4.82731958
9presynaptic membrane organization (GO:0097090)4.79089680
10ensheathment of neurons (GO:0007272)4.79059987
11axon ensheathment (GO:0008366)4.79059987
12cholesterol biosynthetic process (GO:0006695)4.40782672
13oligodendrocyte differentiation (GO:0048709)4.28518483
14chromatin remodeling at centromere (GO:0031055)4.24749448
15GPI anchor biosynthetic process (GO:0006506)4.24666024
16response to redox state (GO:0051775)4.24261072
17response to pheromone (GO:0019236)4.23046746
18DNA double-strand break processing (GO:0000729)4.22294535
19L-amino acid import (GO:0043092)4.18692472
20CENP-A containing nucleosome assembly (GO:0034080)4.18130965
21cullin deneddylation (GO:0010388)4.15167855
22limb bud formation (GO:0060174)4.12317168
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08542305
24neuron cell-cell adhesion (GO:0007158)4.03608008
25activated T cell proliferation (GO:0050798)4.00062951
26replication fork processing (GO:0031297)3.99927594
27GPI anchor metabolic process (GO:0006505)3.88622312
28positive regulation of cellular amine metabolic process (GO:0033240)3.84722512
29histone H2B ubiquitination (GO:0033523)3.83939409
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.82563760
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.82492598
32ATP synthesis coupled proton transport (GO:0015986)3.82492598
33protein deneddylation (GO:0000338)3.82166989
34regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.80538177
35preassembly of GPI anchor in ER membrane (GO:0016254)3.79659351
36histone exchange (GO:0043486)3.78733241
37respiratory electron transport chain (GO:0022904)3.78601245
38mitotic metaphase plate congression (GO:0007080)3.78365858
39sterol biosynthetic process (GO:0016126)3.72874765
40positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.72178024
41photoreceptor cell differentiation (GO:0046530)3.70956310
42eye photoreceptor cell differentiation (GO:0001754)3.70956310
43respiratory chain complex IV assembly (GO:0008535)3.69026269
44isoprenoid biosynthetic process (GO:0008299)3.68621107
45amino acid import (GO:0043090)3.68247405
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68146629
47substantia nigra development (GO:0021762)3.67478945
48kinetochore organization (GO:0051383)3.67120615
49electron transport chain (GO:0022900)3.64997879
50metaphase plate congression (GO:0051310)3.56962418
51chaperone-mediated protein transport (GO:0072321)3.55507562
52protein localization to kinetochore (GO:0034501)3.51253956
53kinetochore assembly (GO:0051382)3.50346845
54regulation of collateral sprouting (GO:0048670)3.48748084
55nucleotide transmembrane transport (GO:1901679)3.48000046
56negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.47409170
57negative regulation of ligase activity (GO:0051352)3.47409170
58mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.43268324
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.43268324
60NADH dehydrogenase complex assembly (GO:0010257)3.43268324
61rRNA modification (GO:0000154)3.42891556
62regulation of cellular amino acid metabolic process (GO:0006521)3.42572750
63DNA replication-independent nucleosome organization (GO:0034724)3.34317213
64DNA replication-independent nucleosome assembly (GO:0006336)3.34317213
65negative regulation of protein localization to cell surface (GO:2000009)3.32675701
66positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.31894905
67spindle checkpoint (GO:0031577)3.28494260
68resolution of meiotic recombination intermediates (GO:0000712)3.28326619
69cytochrome complex assembly (GO:0017004)3.25942728
70protein complex biogenesis (GO:0070271)3.23762722
71DNA replication checkpoint (GO:0000076)3.23595645
72termination of RNA polymerase III transcription (GO:0006386)3.22096522
73transcription elongation from RNA polymerase III promoter (GO:0006385)3.22096522
74import into cell (GO:0098657)3.21831554
75cellular response to epinephrine stimulus (GO:0071872)3.21305243
76regulation of transmission of nerve impulse (GO:0051969)3.20334623
77DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.20051505
78positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19612060
79signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.19401146
80signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.19401146
81signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.19401146
82DNA replication-dependent nucleosome organization (GO:0034723)3.18250061
83DNA replication-dependent nucleosome assembly (GO:0006335)3.18250061
84establishment of protein localization to mitochondrial membrane (GO:0090151)3.17550995
85histone H2A acetylation (GO:0043968)3.17485720
86telomere maintenance via semi-conservative replication (GO:0032201)3.17387874
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16936275
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16936275
89maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.15407625
90regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.13043967
91regulation of mitotic spindle checkpoint (GO:1903504)3.13043967
92mitotic spindle checkpoint (GO:0071174)3.10577406
93negative regulation of execution phase of apoptosis (GO:1900118)3.10419851
94synapsis (GO:0007129)3.09343726
95DNA catabolic process, exonucleolytic (GO:0000738)3.09261901
96protein K6-linked ubiquitination (GO:0085020)3.08668069
97signal transduction involved in cell cycle checkpoint (GO:0072395)3.08422281
98signal transduction involved in DNA integrity checkpoint (GO:0072401)3.07989783
99signal transduction involved in DNA damage checkpoint (GO:0072422)3.07989783
100negative regulation of DNA-dependent DNA replication (GO:2000104)3.07182432
101positive regulation of ligase activity (GO:0051351)3.05474933
102DNA strand elongation involved in DNA replication (GO:0006271)3.03122615
103protein neddylation (GO:0045116)3.01039613
104negative regulation of leukocyte chemotaxis (GO:0002689)3.00786123
105regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.00024373
106proteasome assembly (GO:0043248)2.99694859
107transmission of nerve impulse (GO:0019226)2.99341378
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.98226086
109nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.96462188
110regulation of centriole replication (GO:0046599)2.95175258
111mitotic sister chromatid segregation (GO:0000070)2.94773427
112negative regulation of neurotransmitter secretion (GO:0046929)2.94544727
113negative regulation of axon extension (GO:0030517)2.94384066
114DNA strand elongation (GO:0022616)2.92120693
115regulation of ubiquitin-protein transferase activity (GO:0051438)2.91617450
116negative regulation of DNA recombination (GO:0045910)2.90931340
117negative regulation of sister chromatid segregation (GO:0033046)2.90348627
118negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90348627
119negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.90348627
120negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90348627
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.90348627
122protein localization to chromosome, centromeric region (GO:0071459)2.89840746
123DNA ligation (GO:0006266)2.88780763
124purine nucleobase biosynthetic process (GO:0009113)2.86254485
125somatic hypermutation of immunoglobulin genes (GO:0016446)2.86135069
126somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86135069
127mannosylation (GO:0097502)2.86131147
128C-terminal protein lipidation (GO:0006501)2.85830326
129negative regulation of chromosome segregation (GO:0051985)2.84553621
130mitotic recombination (GO:0006312)2.83918841
131establishment of chromosome localization (GO:0051303)2.83710690
132response to epinephrine (GO:0071871)2.83606295
133microtubule depolymerization (GO:0007019)2.82942577
134amyloid precursor protein metabolic process (GO:0042982)2.82579707
135nucleotide transport (GO:0006862)2.82506283
136sister chromatid segregation (GO:0000819)2.81658470
137regulation of ligase activity (GO:0051340)2.80902445
138spindle assembly checkpoint (GO:0071173)2.79768745
139mitotic spindle assembly checkpoint (GO:0007094)2.79599368
140attachment of spindle microtubules to kinetochore (GO:0008608)2.79145177
141postsynaptic membrane organization (GO:0001941)2.76698283
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.76669568
143regulation of mitotic metaphase/anaphase transition (GO:0030071)2.76669568
144telomere maintenance via recombination (GO:0000722)2.76038854
145non-recombinational repair (GO:0000726)2.74436082
146DNA damage response, detection of DNA damage (GO:0042769)2.73828974
147mitochondrial respiratory chain complex assembly (GO:0033108)2.73268928
148peripheral nervous system development (GO:0007422)2.72333879
149positive regulation of neurological system process (GO:0031646)2.70599561
150retina vasculature morphogenesis in camera-type eye (GO:0061299)2.70318140
151response to methylmercury (GO:0051597)2.69786916
152glycolipid biosynthetic process (GO:0009247)2.68638857
153nucleoside diphosphate catabolic process (GO:0009134)2.68144409
154regulation of rhodopsin mediated signaling pathway (GO:0022400)2.67389834
155creatine metabolic process (GO:0006600)2.66904876
156negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.66098970
157long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.64792022
158long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.64642449
159positive regulation of meiosis (GO:0045836)2.64264570
160righting reflex (GO:0060013)2.63742429
161regulation of mitochondrial translation (GO:0070129)2.58755611
162detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.58328632
163neural nucleus development (GO:0048857)2.57109780
164cyclic nucleotide catabolic process (GO:0009214)2.56464444
165positive regulation of oligodendrocyte differentiation (GO:0048714)2.56164604
166positive regulation of interleukin-4 production (GO:0032753)2.55238133
167adult walking behavior (GO:0007628)2.54923542
168positive regulation of action potential (GO:0045760)2.54575060
169regulation of phospholipid biosynthetic process (GO:0071071)2.54164984
170rhodopsin mediated signaling pathway (GO:0016056)2.53982198
171organ growth (GO:0035265)2.52631206
172negative regulation of neurotransmitter transport (GO:0051589)2.52526296
173membrane assembly (GO:0071709)2.52287001
174astrocyte development (GO:0014002)2.51661111
175C-terminal protein amino acid modification (GO:0018410)2.51060635
176regulation of catecholamine metabolic process (GO:0042069)2.50708900
177regulation of dopamine metabolic process (GO:0042053)2.50708900
178intracellular protein transmembrane import (GO:0044743)2.50096780
179deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.50010094
180glial cell development (GO:0021782)2.49278401
181very long-chain fatty acid metabolic process (GO:0000038)2.48786294
182positive regulation of meiotic cell cycle (GO:0051446)2.48723031
183interleukin-6-mediated signaling pathway (GO:0070102)2.43544245
184negative regulation of acute inflammatory response (GO:0002674)2.43447256

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.38802827
2E2F7_22180533_ChIP-Seq_HELA_Human4.57144699
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.97775135
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.62024768
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.01103401
6TAF15_26573619_Chip-Seq_HEK293_Human2.83080912
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.82238755
8GBX2_23144817_ChIP-Seq_PC3_Human2.82057285
9ELK1_19687146_ChIP-ChIP_HELA_Human2.79457112
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77217663
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69422096
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67229891
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.58200828
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.46851938
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.39954760
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34714835
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.33687599
18ER_23166858_ChIP-Seq_MCF-7_Human2.17273228
19VDR_23849224_ChIP-Seq_CD4+_Human2.15706012
20AR_21909140_ChIP-Seq_LNCAP_Human2.15355261
21* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.14383279
22VDR_22108803_ChIP-Seq_LS180_Human2.06875956
23FUS_26573619_Chip-Seq_HEK293_Human2.04269024
24PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00697772
25ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98732740
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96190318
27* FOXP3_21729870_ChIP-Seq_TREG_Human1.90870708
28EWS_26573619_Chip-Seq_HEK293_Human1.90582785
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89328493
30IRF1_19129219_ChIP-ChIP_H3396_Human1.86915882
31HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.86042149
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.85886930
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.83958460
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82267734
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.81383480
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81335774
37DCP1A_22483619_ChIP-Seq_HELA_Human1.80073707
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79752264
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75969814
40MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72912449
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70354222
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.67622640
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66415167
44KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65993309
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.63584057
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63225315
47SUZ12_18555785_Chip-Seq_ESCs_Mouse1.63126791
48EZH2_22144423_ChIP-Seq_EOC_Human1.62555931
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.62440369
50MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62241559
51SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61362869
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.60656299
53P300_18555785_Chip-Seq_ESCs_Mouse1.59020462
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.58509611
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57168987
56EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57018879
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.56794880
58E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56747821
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.56372333
60NANOG_18555785_Chip-Seq_ESCs_Mouse1.56274223
61ZNF274_21170338_ChIP-Seq_K562_Hela1.55324439
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.55082833
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54602948
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54109981
65* GABP_19822575_ChIP-Seq_HepG2_Human1.53569196
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.53426153
67EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.52794659
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.51442018
69MYC_18940864_ChIP-ChIP_HL60_Human1.49453031
70P53_22387025_ChIP-Seq_ESCs_Mouse1.48727453
71P300_19829295_ChIP-Seq_ESCs_Human1.47837544
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46159703
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45896031
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.45889066
75JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.45583348
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.44741274
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.44729694
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.44584998
79CMYC_18555785_Chip-Seq_ESCs_Mouse1.44087915
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.43214985
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42536606
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.41397859
83TTF2_22483619_ChIP-Seq_HELA_Human1.40243916
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.39335040
85IGF1R_20145208_ChIP-Seq_DFB_Human1.39144000
86SMAD3_21741376_ChIP-Seq_EPCs_Human1.36568441
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.36153303
88SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.35418943
89EED_16625203_ChIP-ChIP_MESCs_Mouse1.35409799
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.34931570
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.34256181
92SOX2_18555785_Chip-Seq_ESCs_Mouse1.34206150
93CREB1_15753290_ChIP-ChIP_HEK293T_Human1.33129061
94NMYC_18555785_Chip-Seq_ESCs_Mouse1.32625559
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32176724
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.31020987
97SMAD1_18555785_Chip-Seq_ESCs_Mouse1.30836247
98PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29762594
99ZFX_18555785_Chip-Seq_ESCs_Mouse1.28646458
100SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.27951060
101EOMES_21245162_ChIP-Seq_HESCs_Human1.27688902
102MYC_19079543_ChIP-ChIP_MESCs_Mouse1.26334313
103EST1_17652178_ChIP-ChIP_JURKAT_Human1.25592081
104SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.24625762
105EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.24381988
106EZH2_27294783_Chip-Seq_ESCs_Mouse1.24118496
107GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23968288
108HTT_18923047_ChIP-ChIP_STHdh_Human1.23338284
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.23244722
110CRX_20693478_ChIP-Seq_RETINA_Mouse1.21757214
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.21344885
112RBPJ_22232070_ChIP-Seq_NCS_Mouse1.20843095
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.19485310
114KLF4_18555785_Chip-Seq_ESCs_Mouse1.19165593
115ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18024956
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17964691
117NOTCH1_21737748_ChIP-Seq_TLL_Human1.16841750
118PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14996263
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14918165
120POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14680444
121* TAL1_26923725_Chip-Seq_HPCs_Mouse1.14285052
122CTCF_18555785_Chip-Seq_ESCs_Mouse1.13733757
123CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.12958413
124RNF2_27304074_Chip-Seq_NSC_Mouse1.12252428
125SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11405067
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11323774
127EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11226017
128RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11226017
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.10858492
130NANOG_16153702_ChIP-ChIP_HESCs_Human1.10180921
131PU1_27457419_Chip-Seq_LIVER_Mouse1.09916990
132GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.09361561
133SRF_21415370_ChIP-Seq_HL-1_Mouse1.08638363
134JARID2_20075857_ChIP-Seq_MESCs_Mouse1.07937986
135SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07666631
136SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07174638
137SOX2_16153702_ChIP-ChIP_HESCs_Human1.06200140
138MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06123951
139AR_21572438_ChIP-Seq_LNCaP_Human1.05270633
140MTF2_20144788_ChIP-Seq_MESCs_Mouse1.04440686
141PHF8_20622853_ChIP-Seq_HELA_Human1.01700503
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.00351834
143RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.00338941
144XRN2_22483619_ChIP-Seq_HELA_Human1.00195106
145ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99601207
146HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.99039834
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98827743
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97665376
149HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96792432
150MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.96750801
151POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95324438
152AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94712235
153KDM5A_27292631_Chip-Seq_BREAST_Human0.92950661
154PIAS1_25552417_ChIP-Seq_VCAP_Human0.89949663
155NANOG_19829295_ChIP-Seq_ESCs_Human0.88482890
156SOX2_19829295_ChIP-Seq_ESCs_Human0.88482890
157CBP_20019798_ChIP-Seq_JUKART_Human0.87760473
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87760473
159SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87113121
160EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.86139579
161ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84153360
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.84043789
163ELK1_22589737_ChIP-Seq_MCF10A_Human0.83699920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.91975092
2MP0010094_abnormal_chromosome_stability3.91682886
3MP0003136_yellow_coat_color3.86004602
4MP0000920_abnormal_myelination3.69532878
5MP0000372_irregular_coat_pigmentation3.31713686
6MP0005171_absent_coat_pigmentation3.21401745
7MP0003693_abnormal_embryo_hatching3.19991284
8MP0001529_abnormal_vocalization3.13631247
9MP0004381_abnormal_hair_follicle2.88965851
10MP0004957_abnormal_blastocyst_morpholog2.63786920
11MP0004742_abnormal_vestibular_system2.57428587
12MP0003111_abnormal_nucleus_morphology2.50926188
13MP0001905_abnormal_dopamine_level2.39447661
14MP0003077_abnormal_cell_cycle2.39208459
15MP0001485_abnormal_pinna_reflex2.34976735
16MP0003950_abnormal_plasma_membrane2.31566686
17MP0004142_abnormal_muscle_tone2.30851092
18MP0002876_abnormal_thyroid_physiology2.27985516
19MP0002102_abnormal_ear_morphology2.19148645
20MP0008057_abnormal_DNA_replication2.15420593
21MP0003690_abnormal_glial_cell2.13578513
22MP0008007_abnormal_cellular_replicative2.08502303
23MP0002272_abnormal_nervous_system2.08344566
24MP0001486_abnormal_startle_reflex1.97032321
25MP0005187_abnormal_penis_morphology1.94835680
26MP0005379_endocrine/exocrine_gland_phen1.90245110
27MP0000566_synostosis1.90084528
28MP0009046_muscle_twitch1.88272985
29MP0006035_abnormal_mitochondrial_morpho1.86963488
30MP0004270_analgesia1.85602337
31MP0003806_abnormal_nucleotide_metabolis1.84158215
32MP0003186_abnormal_redox_activity1.82461690
33MP0009379_abnormal_foot_pigmentation1.78574258
34MP0006036_abnormal_mitochondrial_physio1.76308179
35MP0001188_hyperpigmentation1.72367000
36MP0000462_abnormal_digestive_system1.71727508
37MP0000778_abnormal_nervous_system1.69637087
38MP0006276_abnormal_autonomic_nervous1.66509704
39MP0002064_seizures1.65976006
40MP0005409_darkened_coat_color1.65642333
41MP0003121_genomic_imprinting1.64003892
42MP0008789_abnormal_olfactory_epithelium1.63070610
43MP0005408_hypopigmentation1.62038852
44MP0004145_abnormal_muscle_electrophysio1.61371724
45MP0005551_abnormal_eye_electrophysiolog1.59384560
46MP0001984_abnormal_olfaction1.56297513
47MP0006072_abnormal_retinal_apoptosis1.51828869
48MP0003868_abnormal_feces_composition1.51628523
49MP0001963_abnormal_hearing_physiology1.48184811
50MP0001293_anophthalmia1.46516404
51MP0003786_premature_aging1.46177318
52MP0001346_abnormal_lacrimal_gland1.44998144
53MP0009745_abnormal_behavioral_response1.43963947
54MP0001440_abnormal_grooming_behavior1.38100020
55MP0002090_abnormal_vision1.38035728
56MP0008875_abnormal_xenobiotic_pharmacok1.37181496
57MP0002938_white_spotting1.36778730
58MP0005253_abnormal_eye_physiology1.34922447
59MP0004134_abnormal_chest_morphology1.34688123
60MP0001661_extended_life_span1.34341219
61MP0003195_calcinosis1.32092980
62MP0002234_abnormal_pharynx_morphology1.31427202
63MP0003938_abnormal_ear_development1.31303301
64MP0002229_neurodegeneration1.30936854
65MP0006292_abnormal_olfactory_placode1.28409093
66MP0003890_abnormal_embryonic-extraembry1.28389051
67MP0000383_abnormal_hair_follicle1.28183336
68MP0002638_abnormal_pupillary_reflex1.25960418
69MP0002163_abnormal_gland_morphology1.25140334
70MP0005451_abnormal_body_composition1.25028288
71MP0004924_abnormal_behavior1.24964775
72MP0005386_behavior/neurological_phenoty1.24964775
73MP0002734_abnormal_mechanical_nocicepti1.24800615
74MP0004885_abnormal_endolymph1.23946991
75MP0002095_abnormal_skin_pigmentation1.23647037
76MP0002067_abnormal_sensory_capabilities1.19029736
77MP0005423_abnormal_somatic_nervous1.18795813
78MP0000358_abnormal_cell_content/1.17600495
79MP0001324_abnormal_eye_pigmentation1.16626785
80MP0001177_atelectasis1.14232596
81MP0003315_abnormal_perineum_morphology1.14222765
82MP0003634_abnormal_glial_cell1.13060481
83MP0001929_abnormal_gametogenesis1.12642545
84MP0002160_abnormal_reproductive_system1.12100809
85MP0002572_abnormal_emotion/affect_behav1.11552726
86MP0001348_abnormal_lacrimal_gland1.10997268
87MP0002277_abnormal_respiratory_mucosa1.10730626
88MP0005499_abnormal_olfactory_system1.10721172
89MP0005394_taste/olfaction_phenotype1.10721172
90MP0003718_maternal_effect1.10403527
91MP0003122_maternal_imprinting1.08959211
92MP0002210_abnormal_sex_determination1.07623413
93MP0005084_abnormal_gallbladder_morpholo1.07289590
94MP0002752_abnormal_somatic_nervous1.06579530
95MP0000026_abnormal_inner_ear1.05404456
96MP0004147_increased_porphyrin_level1.04806539
97MP0002736_abnormal_nociception_after1.04762013
98MP0004133_heterotaxia1.02269551
99MP0001851_eye_inflammation1.02142936
100MP0003635_abnormal_synaptic_transmissio1.00992276
101MP0000427_abnormal_hair_cycle0.99614243
102MP0003787_abnormal_imprinting0.99439053
103MP0002882_abnormal_neuron_morphology0.99194479
104MP0002233_abnormal_nose_morphology0.98671809
105MP0009697_abnormal_copulation0.96011155
106MP0001727_abnormal_embryo_implantation0.95693946
107MP0010307_abnormal_tumor_latency0.95563247
108MP0000569_abnormal_digit_pigmentation0.95270155
109MP0008877_abnormal_DNA_methylation0.94760384
110MP0005195_abnormal_posterior_eye0.93099955
111MP0000613_abnormal_salivary_gland0.93040675
112MP0005410_abnormal_fertilization0.92973309
113MP0000653_abnormal_sex_gland0.92672752
114MP0004215_abnormal_myocardial_fiber0.92388838
115MP0002751_abnormal_autonomic_nervous0.91431982
116MP0003123_paternal_imprinting0.91173294
117MP0003632_abnormal_nervous_system0.90883826
118MP0001697_abnormal_embryo_size0.90233854
119MP0001968_abnormal_touch/_nociception0.90209587
120MP0002295_abnormal_pulmonary_circulatio0.90114961
121MP0002066_abnormal_motor_capabilities/c0.87723972
122MP0005389_reproductive_system_phenotype0.87588578
123MP0001986_abnormal_taste_sensitivity0.87065360
124MP0000350_abnormal_cell_proliferation0.86987827
125MP0001145_abnormal_male_reproductive0.86772165
126MP0005075_abnormal_melanosome_morpholog0.86253414
127MP0002063_abnormal_learning/memory/cond0.82823108
128MP0001119_abnormal_female_reproductive0.82372736
129MP0005391_vision/eye_phenotype0.81926095
130MP0008932_abnormal_embryonic_tissue0.81412906
131MP0005646_abnormal_pituitary_gland0.80615419
132MP0003755_abnormal_palate_morphology0.80589671
133MP0005085_abnormal_gallbladder_physiolo0.80424201
134MP0002877_abnormal_melanocyte_morpholog0.80412466
135MP0005395_other_phenotype0.80328757
136MP0003646_muscle_fatigue0.80071574
137MP0000762_abnormal_tongue_morphology0.78643226
138MP0000647_abnormal_sebaceous_gland0.78135929
139MP0003937_abnormal_limbs/digits/tail_de0.77399633
140MP0005248_abnormal_Harderian_gland0.77141201
141MP0001286_abnormal_eye_development0.77050409
142MP0001764_abnormal_homeostasis0.76610635
143MP0010386_abnormal_urinary_bladder0.76471466
144MP0001970_abnormal_pain_threshold0.75453717
145MP0000049_abnormal_middle_ear0.75450925
146MP0003698_abnormal_male_reproductive0.74311983
147MP0002735_abnormal_chemical_nociception0.72882066
148MP0003567_abnormal_fetal_cardiomyocyte0.71890739
149MP0002837_dystrophic_cardiac_calcinosis0.70912401
150MP0002111_abnormal_tail_morphology0.68828229
151MP0009703_decreased_birth_body0.66860093
152MP0002084_abnormal_developmental_patter0.66589056
153MP0005174_abnormal_tail_pigmentation0.66522360
154MP0002557_abnormal_social/conspecific_i0.65692776
155MP0001299_abnormal_eye_distance/0.64181536
156MP0003011_delayed_dark_adaptation0.63469413
157MP0000631_abnormal_neuroendocrine_gland0.61811582
158MP0002733_abnormal_thermal_nociception0.61595138
159MP0005332_abnormal_amino_acid0.61394990
160MP0008058_abnormal_DNA_repair0.61349269

Predicted human phenotypes

RankGene SetZ-score
1Parakeratosis (HP:0001036)4.88192616
2Renal Fanconi syndrome (HP:0001994)4.54125260
3Increased hepatocellular lipid droplets (HP:0006565)4.12270928
4Sensory axonal neuropathy (HP:0003390)3.85268671
5Stenosis of the external auditory canal (HP:0000402)3.76319225
6Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.75025714
7Acute necrotizing encephalopathy (HP:0006965)3.72615736
8Mitochondrial inheritance (HP:0001427)3.67568163
9Lipid accumulation in hepatocytes (HP:0006561)3.58229780
10Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.57759237
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.57759237
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.50637761
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.44384517
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.39930450
15Split foot (HP:0001839)3.39260964
16Chromsome breakage (HP:0040012)3.38795884
17Peripheral hypomyelination (HP:0007182)3.24162120
18Meckel diverticulum (HP:0002245)3.22692076
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.22555292
20Increased CSF lactate (HP:0002490)3.17484498
21Acute encephalopathy (HP:0006846)3.10989609
22Abnormality of chromosome stability (HP:0003220)3.06988592
23Progressive macrocephaly (HP:0004481)3.04495103
24Abnormality of the ileum (HP:0001549)3.03672487
25Increased intramyocellular lipid droplets (HP:0012240)3.02757740
26Abnormal mitochondria in muscle tissue (HP:0008316)2.99213401
27Abnormality of renal resorption (HP:0011038)2.98930879
28Abnormality of the labia minora (HP:0012880)2.98020141
29Alacrima (HP:0000522)2.96804233
30Leukodystrophy (HP:0002415)2.91251869
31Cerebral hypomyelination (HP:0006808)2.86448321
32Spastic paraparesis (HP:0002313)2.86396770
33Hypoplastic pelvis (HP:0008839)2.83023523
34Type I transferrin isoform profile (HP:0003642)2.79521776
35Abnormality of the preputium (HP:0100587)2.76893718
36Hepatocellular necrosis (HP:0001404)2.68774713
37White forelock (HP:0002211)2.66611526
38Exertional dyspnea (HP:0002875)2.62941763
39Volvulus (HP:0002580)2.62659228
40Decreased lacrimation (HP:0000633)2.62354826
41Patchy hypopigmentation of hair (HP:0011365)2.59511538
42Medial flaring of the eyebrow (HP:0010747)2.56696666
43Optic disc pallor (HP:0000543)2.55099217
44Small intestinal stenosis (HP:0012848)2.50440113
45Duodenal stenosis (HP:0100867)2.50440113
46Abnormality of methionine metabolism (HP:0010901)2.50293852
47Focal motor seizures (HP:0011153)2.45537690
48Congenital sensorineural hearing impairment (HP:0008527)2.45164088
49Congenital ichthyosiform erythroderma (HP:0007431)2.41733767
50Adrenal hypoplasia (HP:0000835)2.40116063
51Congenital primary aphakia (HP:0007707)2.38237995
52Increased muscle lipid content (HP:0009058)2.38059643
53Abnormal lung lobation (HP:0002101)2.36793702
54Colon cancer (HP:0003003)2.36394674
55Glioma (HP:0009733)2.35073338
56Cupped ear (HP:0000378)2.34571498
57Cerebral edema (HP:0002181)2.33966216
58Abnormality of the duodenum (HP:0002246)2.31671782
59Median cleft lip (HP:0000161)2.30815008
60Absent/shortened dynein arms (HP:0200106)2.29254982
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.29254982
62Neurofibrillary tangles (HP:0002185)2.29214141
63Progressive external ophthalmoplegia (HP:0000590)2.28290838
64Small epiphyses (HP:0010585)2.28134165
65Gait imbalance (HP:0002141)2.27830189
66Oligodactyly (hands) (HP:0001180)2.27513793
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26433222
683-Methylglutaconic aciduria (HP:0003535)2.26408071
69Pancreatic cysts (HP:0001737)2.26232842
70Septo-optic dysplasia (HP:0100842)2.25703377
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25417598
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25417598
73Respiratory difficulties (HP:0002880)2.23628959
74Renal cortical cysts (HP:0000803)2.23223570
75Polyphagia (HP:0002591)2.21709567
76Nephrogenic diabetes insipidus (HP:0009806)2.20469632
77True hermaphroditism (HP:0010459)2.20111989
78Prolonged partial thromboplastin time (HP:0003645)2.19775915
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18855313
80Abnormal protein N-linked glycosylation (HP:0012347)2.18855313
81Abnormal protein glycosylation (HP:0012346)2.18855313
82Abnormal glycosylation (HP:0012345)2.18855313
83Nasolacrimal duct obstruction (HP:0000579)2.16884443
84Duplicated collecting system (HP:0000081)2.16319678
85Abnormality of the corticospinal tract (HP:0002492)2.15918282
86Pancreatic fibrosis (HP:0100732)2.14556601
87Abnormality of urine glucose concentration (HP:0011016)2.13934037
88Glycosuria (HP:0003076)2.13934037
89Hepatic necrosis (HP:0002605)2.13635345
90Abnormality of the renal collecting system (HP:0004742)2.13183955
91Sloping forehead (HP:0000340)2.10270051
92Morphological abnormality of the inner ear (HP:0011390)2.09981143
93Methylmalonic acidemia (HP:0002912)2.09625277
94Absent septum pellucidum (HP:0001331)2.09459808
95Retinal dysplasia (HP:0007973)2.08824261
96Neoplasm of the adrenal gland (HP:0100631)2.07174682
97Abnormality of midbrain morphology (HP:0002418)2.06591687
98Molar tooth sign on MRI (HP:0002419)2.06591687
99Abnormality of alanine metabolism (HP:0010916)2.06199988
100Hyperalaninemia (HP:0003348)2.06199988
101Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06199988
102Muscle hypertrophy of the lower extremities (HP:0008968)2.06063844
103Abnormality of the septum pellucidum (HP:0007375)2.05907297
104Birth length less than 3rd percentile (HP:0003561)2.05163038
105Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.04962131
106Absent epiphyses (HP:0010577)2.04962131
107Congenital malformation of the right heart (HP:0011723)2.03710720
108Double outlet right ventricle (HP:0001719)2.03710720
109Abnormality of the fovea (HP:0000493)2.01464056
110Abnormality of aspartate family amino acid metabolism (HP:0010899)2.00977865
111Abnormality of the carotid arteries (HP:0005344)1.99949604
112Dysmetria (HP:0001310)1.99587170
113Thickened helices (HP:0000391)1.99332276
114Abnormality of the astrocytes (HP:0100707)1.99290111
115Astrocytoma (HP:0009592)1.99290111
116Premature skin wrinkling (HP:0100678)1.98949012
117Aplasia/Hypoplasia of the fovea (HP:0008060)1.98919466
118Hypoplasia of the fovea (HP:0007750)1.98919466
119Astigmatism (HP:0000483)1.98731130
120Abnormal urine phosphate concentration (HP:0012599)1.98590182
121Akinesia (HP:0002304)1.97396663
122Ependymoma (HP:0002888)1.96738226
123Abnormality of the anterior horn cell (HP:0006802)1.95349199
124Degeneration of anterior horn cells (HP:0002398)1.95349199
125Lethargy (HP:0001254)1.94869461
126Tubulointerstitial nephritis (HP:0001970)1.94546886
127Exercise intolerance (HP:0003546)1.93922475
128Genital tract atresia (HP:0001827)1.93740623
129Clubbing of toes (HP:0100760)1.93378263
130Submucous cleft hard palate (HP:0000176)1.93321674
131Vaginal atresia (HP:0000148)1.92172944
132Hyperphosphaturia (HP:0003109)1.91400142
133Aplasia/Hypoplasia involving the musculature (HP:0001460)1.89281950
134Hypophosphatemic rickets (HP:0004912)1.88459573
135Generalized myoclonic seizures (HP:0002123)1.88362314
136Steppage gait (HP:0003376)1.88129737
137Breast hypoplasia (HP:0003187)1.86270825
138Rhabdomyosarcoma (HP:0002859)1.86086164
139Anomalous pulmonary venous return (HP:0010772)1.86029075
140Increased serum lactate (HP:0002151)1.85201473
141Intestinal atresia (HP:0011100)1.84598260
142Cortical dysplasia (HP:0002539)1.83185967
143Respiratory failure (HP:0002878)1.82463406
144Irregular epiphyses (HP:0010582)1.82359689
145Nephronophthisis (HP:0000090)1.80518246
146Reduced antithrombin III activity (HP:0001976)1.80481074
147Renal tubular dysfunction (HP:0000124)1.80444221
148Abnormality of incisor morphology (HP:0011063)1.80025809
149Medulloblastoma (HP:0002885)1.79685640
150Esotropia (HP:0000565)1.78694434
151Ureteral duplication (HP:0000073)1.78461776
152Delayed epiphyseal ossification (HP:0002663)1.77966874
153Delayed puberty (HP:0000823)1.77578197
154CNS demyelination (HP:0007305)1.75431231
155Increased serum pyruvate (HP:0003542)1.74935091
156Abnormality of glycolysis (HP:0004366)1.74935091
157Postaxial hand polydactyly (HP:0001162)1.74656588
158Sclerocornea (HP:0000647)1.74572000
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.74418195
160Triphalangeal thumb (HP:0001199)1.74353903
161Aganglionic megacolon (HP:0002251)1.72733007
162CNS hypomyelination (HP:0003429)1.72393537
163Lactic acidosis (HP:0003128)1.71160940
164Abnormal ciliary motility (HP:0012262)1.71079335
165Myelodysplasia (HP:0002863)1.69575239
166Conical tooth (HP:0000698)1.69414886
167Partial duplication of thumb phalanx (HP:0009944)1.69302193
168Mixed hearing impairment (HP:0000410)1.68792905
169Overfolded helix (HP:0000396)1.68434518
170Preaxial hand polydactyly (HP:0001177)1.68243860
171Bifid tongue (HP:0010297)1.68080851
172Intrahepatic cholestasis (HP:0001406)1.67215273
173Hyperinsulinemic hypoglycemia (HP:0000825)1.66333419
174X-linked dominant inheritance (HP:0001423)1.65593064

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.99586939
2EPHB13.98756300
3CASK3.25012112
4STK163.18703996
5OXSR13.13812965
6WEE12.89043725
7TNIK2.75701026
8TSSK62.68548058
9PKN12.61243684
10PLK32.58352908
11TRIM282.55639936
12PLK42.51263365
13NEK12.49973295
14CDK192.48857887
15FES2.39563158
16PNCK2.25872555
17CDC72.25011353
18BRSK22.20718543
19EIF2AK32.18111268
20WNK32.14889329
21CLK12.07524262
22IRAK32.06377571
23FRK2.05147702
24BCR2.04764649
25IRAK21.93028911
26VRK21.92974888
27PDK21.90370983
28BUB11.75104399
29NEK61.72903252
30PBK1.72038106
31MET1.71001406
32IRAK41.63189196
33PLK21.54004583
34WNK41.52989693
35PLK11.50934956
36IRAK11.46630758
37ERBB31.41544450
38TYRO31.41218857
39SRPK11.39860375
40CSNK1G31.37950878
41BMPR1B1.33261332
42FER1.32129105
43INSRR1.31325151
44NUAK11.25755063
45MARK11.25332806
46BRSK11.23688286
47PRPF4B1.22804924
48TLK11.18423975
49FGR1.18305248
50MST41.17120058
51GRK71.15749064
52CSNK1A1L1.14683797
53UHMK11.12465159
54CCNB11.12080826
55BRAF1.11614174
56NME11.10217649
57NME21.08987472
58MAP2K21.08222051
59MAP4K21.06345821
60CAMK2B0.99541109
61CSNK1G10.98354545
62EPHA40.97669221
63AURKB0.97378823
64MAP3K40.94883842
65MAPK130.93854730
66MAP3K120.92160669
67PRKCQ0.91223811
68ATR0.90076300
69CAMK2D0.87344555
70BMPR20.85776914
71BCKDK0.85127253
72CHEK20.84389394
73DYRK20.82885456
74ZAK0.82611465
75ROCK20.80439067
76RPS6KA40.75240546
77YES10.74844594
78ICK0.74410710
79TNK20.74288192
80ATM0.74106150
81CSNK1G20.71914729
82WNK10.71571285
83MAPK150.67360029
84MKNK20.66696182
85ADRBK20.66337126
86MINK10.64480106
87OBSCN0.64280737
88EIF2AK20.64131892
89ABL20.63754542
90MKNK10.63576690
91CAMK2A0.62788324
92BLK0.62573732
93PRKCG0.61176654
94MAP2K70.61095441
95VRK10.60160981
96TTK0.58550582
97PAK30.57232657
98CSK0.56769817
99STK38L0.56237623
100SGK2230.56025442
101SGK4940.56025442
102TGFBR10.55450890
103EIF2AK10.55075852
104CHEK10.54715467
105CDK80.52265924
106CAMK2G0.51703342
107TAF10.49485066
108CSNK2A10.46839547
109LIMK10.46833984
110PIK3CG0.46545865
111ERBB40.46415770
112GRK10.46210313
113DYRK1A0.45999840
114PRKCE0.45595278
115PINK10.43858869
116PRKG10.43537904
117PRKCI0.43104564
118MARK20.41181857
119FGFR20.41096596
120CDK50.40335975
121ACVR1B0.39494692
122LCK0.38941406
123CSNK2A20.38496664
124MARK30.38390318
125NEK20.38129427
126MAP3K140.38056821
127CSNK1E0.36463000
128RAF10.36339532
129AURKA0.36074093
130CDK140.35881877
131STK30.35580538
132PRKACA0.35278019
133CDK10.33339898
134NLK0.32318305
135INSR0.31879489
136DYRK30.31768708
137LYN0.30933394
138MUSK0.30660011
139RPS6KA50.30621772
140BRD40.30582469
141CSNK1A10.30232455
142CDK30.30095276
143ADRBK10.29020500
144FYN0.28949490
145MAPKAPK50.28948969
146AKT30.28869737
147STK40.28618862
148PRKD20.28385012
149CDK11A0.27457789
150PDGFRB0.27362174
151CAMKK20.26238043
152PRKDC0.25506851
153MYLK0.25037680
154ILK0.22719167
155TIE10.22687402
156PASK0.22008668
157CSNK1D0.21841681

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.70015966
2Oxidative phosphorylation_Homo sapiens_hsa001904.24778924
3Steroid biosynthesis_Homo sapiens_hsa001003.76515949
4Fatty acid elongation_Homo sapiens_hsa000623.63609491
5Mismatch repair_Homo sapiens_hsa034303.21534987
6Parkinsons disease_Homo sapiens_hsa050123.02965455
7DNA replication_Homo sapiens_hsa030302.75291421
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.72320072
9Protein export_Homo sapiens_hsa030602.71209370
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.66937417
11RNA polymerase_Homo sapiens_hsa030202.53965075
12Ether lipid metabolism_Homo sapiens_hsa005652.42654916
13Alzheimers disease_Homo sapiens_hsa050102.41127502
14Ribosome_Homo sapiens_hsa030102.24148791
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08283998
16Sulfur metabolism_Homo sapiens_hsa009202.08202511
17Huntingtons disease_Homo sapiens_hsa050162.03843057
18Base excision repair_Homo sapiens_hsa034102.01999738
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.92615882
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.80452701
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79379816
22RNA transport_Homo sapiens_hsa030131.70243743
23Butanoate metabolism_Homo sapiens_hsa006501.68007612
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.67479147
25Linoleic acid metabolism_Homo sapiens_hsa005911.58713175
26Collecting duct acid secretion_Homo sapiens_hsa049661.53859025
27Cell cycle_Homo sapiens_hsa041101.53503719
28One carbon pool by folate_Homo sapiens_hsa006701.52382578
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.51978578
30Proteasome_Homo sapiens_hsa030501.51758271
31Vitamin B6 metabolism_Homo sapiens_hsa007501.48781747
32Sphingolipid metabolism_Homo sapiens_hsa006001.48077489
33Peroxisome_Homo sapiens_hsa041461.41784330
34Axon guidance_Homo sapiens_hsa043601.35980152
35Pyruvate metabolism_Homo sapiens_hsa006201.34700913
36Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.33126765
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28154225
38Phototransduction_Homo sapiens_hsa047441.24126261
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.22759987
40beta-Alanine metabolism_Homo sapiens_hsa004101.18277756
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.17945264
42Selenocompound metabolism_Homo sapiens_hsa004501.17868641
43Arachidonic acid metabolism_Homo sapiens_hsa005901.14431719
44Histidine metabolism_Homo sapiens_hsa003401.10576232
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.10116080
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08306538
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07734788
48Serotonergic synapse_Homo sapiens_hsa047261.06450310
49Vibrio cholerae infection_Homo sapiens_hsa051101.04918337
50Cardiac muscle contraction_Homo sapiens_hsa042601.04038735
51Arginine and proline metabolism_Homo sapiens_hsa003301.03648229
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97089672
53Sulfur relay system_Homo sapiens_hsa041220.95684463
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.93615854
55Oocyte meiosis_Homo sapiens_hsa041140.93282765
56Pyrimidine metabolism_Homo sapiens_hsa002400.93272504
57Glutathione metabolism_Homo sapiens_hsa004800.93092576
58Non-homologous end-joining_Homo sapiens_hsa034500.93044044
59Rheumatoid arthritis_Homo sapiens_hsa053230.91279602
60Homologous recombination_Homo sapiens_hsa034400.89937250
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88647059
62Metabolic pathways_Homo sapiens_hsa011000.85563381
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85084966
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85033088
65Propanoate metabolism_Homo sapiens_hsa006400.82117480
66Other glycan degradation_Homo sapiens_hsa005110.81026378
67Phenylalanine metabolism_Homo sapiens_hsa003600.80861384
68Purine metabolism_Homo sapiens_hsa002300.79789802
69Fatty acid degradation_Homo sapiens_hsa000710.78473430
70Tyrosine metabolism_Homo sapiens_hsa003500.78400516
71Folate biosynthesis_Homo sapiens_hsa007900.77721549
72Chemical carcinogenesis_Homo sapiens_hsa052040.72178690
73Nicotine addiction_Homo sapiens_hsa050330.71710931
74Carbon metabolism_Homo sapiens_hsa012000.70518457
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.70384419
76N-Glycan biosynthesis_Homo sapiens_hsa005100.69514036
77Retinol metabolism_Homo sapiens_hsa008300.66863875
78p53 signaling pathway_Homo sapiens_hsa041150.66826944
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65752794
80ABC transporters_Homo sapiens_hsa020100.65115333
81Fanconi anemia pathway_Homo sapiens_hsa034600.65071713
82Basal transcription factors_Homo sapiens_hsa030220.63632340
83Glutamatergic synapse_Homo sapiens_hsa047240.63392279
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.62299410
85Morphine addiction_Homo sapiens_hsa050320.61087362
86mRNA surveillance pathway_Homo sapiens_hsa030150.60587780
87Long-term depression_Homo sapiens_hsa047300.59611607
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58642347
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.57703912
90Autoimmune thyroid disease_Homo sapiens_hsa053200.57486026
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.56820010
92Prion diseases_Homo sapiens_hsa050200.56349037
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55156117
94GABAergic synapse_Homo sapiens_hsa047270.54227006
95Fatty acid metabolism_Homo sapiens_hsa012120.53569823
96Biosynthesis of amino acids_Homo sapiens_hsa012300.53071653
97Caffeine metabolism_Homo sapiens_hsa002320.52987961
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50785175
99Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49012650
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48780000
101Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48105638
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47017911
103Taste transduction_Homo sapiens_hsa047420.46807047
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46000909
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45623591
106Vitamin digestion and absorption_Homo sapiens_hsa049770.45464323
107Nucleotide excision repair_Homo sapiens_hsa034200.41831399
108Fatty acid biosynthesis_Homo sapiens_hsa000610.38317075
109Ovarian steroidogenesis_Homo sapiens_hsa049130.37973707
110Spliceosome_Homo sapiens_hsa030400.35957261
111Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33112099
112Hedgehog signaling pathway_Homo sapiens_hsa043400.31351661
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.30673743
114RNA degradation_Homo sapiens_hsa030180.29111696
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26957381
116Alcoholism_Homo sapiens_hsa050340.26654283
117Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25674631
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.25572417
119TGF-beta signaling pathway_Homo sapiens_hsa043500.24207945
120Cholinergic synapse_Homo sapiens_hsa047250.24118478
121Tryptophan metabolism_Homo sapiens_hsa003800.23852555
122Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22934956
123Complement and coagulation cascades_Homo sapiens_hsa046100.22229461
124Nitrogen metabolism_Homo sapiens_hsa009100.21395409
125Regulation of autophagy_Homo sapiens_hsa041400.20314297
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20130734
127Phagosome_Homo sapiens_hsa041450.18482151
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.16360339
129Glycerolipid metabolism_Homo sapiens_hsa005610.15919113
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.12157199
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.11619112
132Ras signaling pathway_Homo sapiens_hsa040140.11508244
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.07978682
134Choline metabolism in cancer_Homo sapiens_hsa052310.07012422
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.05250414

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