FAM175B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)5.43359668
2doxorubicin metabolic process (GO:0044598)5.43359668
3daunorubicin metabolic process (GO:0044597)5.43359668
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.88035661
5neutrophil activation involved in immune response (GO:0002283)4.76039964
6establishment of integrated proviral latency (GO:0075713)4.48033640
7ribosome assembly (GO:0042255)4.45111112
8protein localization to kinetochore (GO:0034501)4.29692591
9mitotic metaphase plate congression (GO:0007080)4.28945377
10protein localization to chromosome, centromeric region (GO:0071459)4.20586491
11CENP-A containing nucleosome assembly (GO:0034080)4.11390029
12nuclear pore complex assembly (GO:0051292)4.03918368
13primary alcohol catabolic process (GO:0034310)4.03082788
14chromatin remodeling at centromere (GO:0031055)3.94678824
15establishment of viral latency (GO:0019043)3.88286485
16nuclear pore organization (GO:0006999)3.86265956
17negative regulation of mast cell activation (GO:0033004)3.84567090
18ventricular cardiac muscle cell development (GO:0055015)3.84539685
19mitotic G2/M transition checkpoint (GO:0044818)3.83840400
20metaphase plate congression (GO:0051310)3.79427796
21endosome to pigment granule transport (GO:0043485)3.79334237
22endosome to melanosome transport (GO:0035646)3.79334237
23mitotic chromosome condensation (GO:0007076)3.78993737
24attachment of spindle microtubules to kinetochore (GO:0008608)3.78660362
25hydrogen peroxide biosynthetic process (GO:0050665)3.75012556
26reactive oxygen species biosynthetic process (GO:1903409)3.74999985
27establishment of chromosome localization (GO:0051303)3.74658916
28DNA strand elongation involved in DNA replication (GO:0006271)3.71622481
29proteasome assembly (GO:0043248)3.69752931
30superoxide anion generation (GO:0042554)3.69746236
31mitochondrial calcium ion transport (GO:0006851)3.69235937
32DNA strand elongation (GO:0022616)3.65278587
33signal peptide processing (GO:0006465)3.63352654
34COPI coating of Golgi vesicle (GO:0048205)3.60825977
35Golgi transport vesicle coating (GO:0048200)3.60825977
36mitotic sister chromatid segregation (GO:0000070)3.59761685
37DNA unwinding involved in DNA replication (GO:0006268)3.55225749
38respiratory burst (GO:0045730)3.55193442
39sister chromatid segregation (GO:0000819)3.54883920
40positive regulation of B cell differentiation (GO:0045579)3.53865593
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.53368353
42anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52442019
43aminoglycoside antibiotic metabolic process (GO:0030647)3.45681498
44DNA replication checkpoint (GO:0000076)3.45114315
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.43944610
46regulation of B cell receptor signaling pathway (GO:0050855)3.41040161
47response to peptidoglycan (GO:0032494)3.40563497
48mitotic sister chromatid cohesion (GO:0007064)3.39918187
49telomere maintenance via semi-conservative replication (GO:0032201)3.38247092
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32447213
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31674713
52double-strand break repair via nonhomologous end joining (GO:0006303)3.27301104
53non-recombinational repair (GO:0000726)3.27301104
54spindle checkpoint (GO:0031577)3.25636565
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.25514173
56regulation of mitotic metaphase/anaphase transition (GO:0030071)3.25514173
57definitive hemopoiesis (GO:0060216)3.24485338
58pore complex assembly (GO:0046931)3.21716798
59mitotic G2 DNA damage checkpoint (GO:0007095)3.21050047
60mitotic nuclear envelope disassembly (GO:0007077)3.20839218
61histone exchange (GO:0043486)3.19693694
62regulation of mitotic spindle checkpoint (GO:1903504)3.19073504
63regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.19073504
64positive regulation by symbiont of host defense response (GO:0052509)3.17147828
65modulation by symbiont of host defense response (GO:0052031)3.17147828
66modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.17147828
67modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.17147828
68positive regulation by organism of defense response of other organism involved in symbiotic interact3.17147828
69modulation by symbiont of host immune response (GO:0052553)3.17147828
70antigen processing and presentation via MHC class Ib (GO:0002475)3.16766293
71telomere maintenance via recombination (GO:0000722)3.16386870
72ribonucleoprotein complex disassembly (GO:0032988)3.15130408
73positive regulation of interferon-alpha production (GO:0032727)3.15099260
74mitotic spindle checkpoint (GO:0071174)3.14177638
75production of molecular mediator involved in inflammatory response (GO:0002532)3.13875770
76positive regulation of protein sumoylation (GO:0033235)3.13504118
77mitotic recombination (GO:0006312)3.12987229
78neutrophil activation (GO:0042119)3.12346965
79organelle disassembly (GO:1903008)3.12119999
80cellular protein complex localization (GO:0034629)3.11726247
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.09727066
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.09727066
83isotype switching (GO:0045190)3.09727066
84regulation of RIG-I signaling pathway (GO:0039535)3.05865542
85positive regulation of interferon-beta production (GO:0032728)3.05232135
86negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05170772
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05170772
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05170772
89negative regulation of mitotic sister chromatid separation (GO:2000816)3.05170772
90negative regulation of sister chromatid segregation (GO:0033046)3.05170772
91negative regulation of ligase activity (GO:0051352)3.04409393
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.04409393
93regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.04287378
94immunoglobulin mediated immune response (GO:0016064)3.01569941
95nuclear envelope disassembly (GO:0051081)3.01167105
96membrane disassembly (GO:0030397)3.01167105
97cullin deneddylation (GO:0010388)2.98012574
98negative regulation of chromosome segregation (GO:0051985)2.97924629
99ribosome biogenesis (GO:0042254)2.97351210
100protein deneddylation (GO:0000338)2.95309750
101regulation of mitotic sister chromatid separation (GO:0010965)2.95202264
102regulation of mitotic sister chromatid segregation (GO:0033047)2.95202264
103regulation of sister chromatid segregation (GO:0033045)2.95202264
104positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.95105073
105granulocyte activation (GO:0036230)2.95024073
106formation of translation preinitiation complex (GO:0001731)2.94965848
107DNA replication-independent nucleosome assembly (GO:0006336)2.94837187
108DNA replication-independent nucleosome organization (GO:0034724)2.94837187
109positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.94807154
110positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.94807154
111positive regulation of mitotic sister chromatid separation (GO:1901970)2.94807154
112mitotic spindle assembly checkpoint (GO:0007094)2.94657532
113G1/S transition of mitotic cell cycle (GO:0000082)2.92353839
114cell cycle G1/S phase transition (GO:0044843)2.92353839
115regulation of B cell differentiation (GO:0045577)2.91290136
116centriole replication (GO:0007099)2.90769901
117DNA double-strand break processing (GO:0000729)2.90682953
118spindle assembly checkpoint (GO:0071173)2.90131124
119negative regulation of phagocytosis (GO:0050765)2.88764793
120regulation of interferon-alpha production (GO:0032647)2.88171365
121positive regulation of ligase activity (GO:0051351)2.87334090
122regulation of mast cell activation (GO:0033003)2.87265461
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.86977759
124signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.86900922
125signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.86900922
126signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86900922
127response to X-ray (GO:0010165)2.86862302
128DNA catabolic process, exonucleolytic (GO:0000738)2.86464754
129detection of other organism (GO:0098543)2.85741764
130intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85023732
131signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85023732
132protein localization to chromosome (GO:0034502)2.84054037
133poly(A)+ mRNA export from nucleus (GO:0016973)2.83936141
134positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.82500406
135positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.82016883
136positive regulation of chromosome segregation (GO:0051984)2.81576457
137regulation of chromosome segregation (GO:0051983)2.80976431
138response to UV-C (GO:0010225)2.80524314
139nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.80298762
140positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.78767076
141neural tube formation (GO:0001841)2.78083205
142negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.77654746
143signal transduction involved in DNA damage checkpoint (GO:0072422)2.77628377
144signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77628377
145regulation of mast cell degranulation (GO:0043304)2.74230698
146regulation of mast cell activation involved in immune response (GO:0033006)2.71484628
147regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71125529
148negative regulation of myeloid cell apoptotic process (GO:0033033)2.70965718
149I-kappaB kinase/NF-kappaB signaling (GO:0007249)2.67212390
150ethanol oxidation (GO:0006069)2.66626373
151detection of molecule of bacterial origin (GO:0032490)2.63270541
152necroptotic process (GO:0070266)2.60192922
153response to host immune response (GO:0052572)2.60047536
154response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60047536
155antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59328043
156positive regulation of cellular amide metabolic process (GO:0034250)2.58269925
157antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.57156913
158regulation of interferon-beta biosynthetic process (GO:0045357)2.57153149
159tryptophan metabolic process (GO:0006568)2.54827319
160programmed necrotic cell death (GO:0097300)2.54019455
161positive regulation of gamma-delta T cell activation (GO:0046645)2.53324238
162protein carboxylation (GO:0018214)2.51651512
163peptidyl-glutamic acid carboxylation (GO:0017187)2.51651512
164indole-containing compound catabolic process (GO:0042436)2.51450144
165indolalkylamine catabolic process (GO:0046218)2.51450144
166tryptophan catabolic process (GO:0006569)2.51450144
167toxin transport (GO:1901998)2.49792339
168regulation of lipoprotein particle clearance (GO:0010984)2.44238940
169antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.43937559
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.43930862
171hepatocyte apoptotic process (GO:0097284)2.43553043
172UDP-N-acetylglucosamine metabolic process (GO:0006047)2.43474110
173glucosamine-containing compound catabolic process (GO:1901072)2.43081426
174regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.42433857
175positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.42408035
176ER overload response (GO:0006983)2.42358299
177glycoside metabolic process (GO:0016137)2.42074767
178organelle membrane fusion (GO:0090174)2.41764309
179intra-S DNA damage checkpoint (GO:0031573)2.38780103
180necrotic cell death (GO:0070265)2.37851810
181detection of external biotic stimulus (GO:0098581)2.35844634
182aldehyde catabolic process (GO:0046185)2.35721861
183positive regulation of respiratory burst (GO:0060267)2.35562254
184response to type I interferon (GO:0034340)2.32742098
185type I interferon signaling pathway (GO:0060337)2.31212166
186cellular response to type I interferon (GO:0071357)2.31212166
187regulation of hexokinase activity (GO:1903299)2.31181560
188regulation of glucokinase activity (GO:0033131)2.31181560
189autophagic vacuole fusion (GO:0000046)2.30905374
190myeloid cell activation involved in immune response (GO:0002275)2.30464906
191detection of bacterium (GO:0016045)2.30453210
192microglial cell activation (GO:0001774)2.29277123
193negative regulation of viral genome replication (GO:0045071)2.26639991
194DNA ligation (GO:0006266)2.26006431
195L-fucose catabolic process (GO:0042355)2.22768061
196fucose catabolic process (GO:0019317)2.22768061
197L-fucose metabolic process (GO:0042354)2.22768061
198ribosomal small subunit assembly (GO:0000028)2.21677077
199positive regulation of macrophage differentiation (GO:0045651)2.21486843

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.44194444
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.45264519
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.42249412
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10149446
5ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82028239
6GATA1_22025678_ChIP-Seq_K562_Human2.77326641
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67381733
8FOXM1_23109430_ChIP-Seq_U2OS_Human2.61491423
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.53013146
10SCL_19346495_ChIP-Seq_HPC-7_Human2.43825883
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.41612134
12AR_21909140_ChIP-Seq_LNCAP_Human2.35670637
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.33384261
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.32044409
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29896354
16BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29576240
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.26703896
18SALL1_21062744_ChIP-ChIP_HESCs_Human2.23703524
19SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.22421575
20SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.16785575
21IRF8_27001747_Chip-Seq_BMDM_Mouse2.15900347
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.15013327
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.12127336
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.11466541
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.08993465
26ELK1_19687146_ChIP-ChIP_HELA_Human2.08352799
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.07234629
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.06591303
29HOXB4_20404135_ChIP-ChIP_EML_Mouse2.05086931
30FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.01233623
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98931464
32MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98540270
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.97635558
34* ETS1_20019798_ChIP-Seq_JURKAT_Human1.97540461
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.97002246
36E2F7_22180533_ChIP-Seq_HELA_Human1.95973921
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.93643532
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93204314
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91962396
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.84634856
41* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.82297392
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.79981591
43MYB_21317192_ChIP-Seq_ERMYB_Mouse1.79430442
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.77670581
45FOXP3_21729870_ChIP-Seq_TREG_Human1.76650606
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.76245182
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73804942
48POU3F2_20337985_ChIP-ChIP_501MEL_Human1.71709329
49* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.66109842
50VDR_23849224_ChIP-Seq_CD4+_Human1.64450599
51MYC_18358816_ChIP-ChIP_MESCs_Mouse1.64442742
52ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.63296211
53* SPI1_23547873_ChIP-Seq_NB4_Human1.61458415
54* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.60006052
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.58622638
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.54028288
57MYC_19079543_ChIP-ChIP_MESCs_Mouse1.53105864
58TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.52341798
59E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51419702
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.51245121
61STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.50564684
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50084190
63* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48579809
64SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.45793692
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45115234
66TFEB_21752829_ChIP-Seq_HELA_Human1.44605903
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.44361169
68GABP_19822575_ChIP-Seq_HepG2_Human1.43854906
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43543421
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43416574
71TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42400307
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41527765
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41462469
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41308727
75FUS_26573619_Chip-Seq_HEK293_Human1.39045755
76EWS_26573619_Chip-Seq_HEK293_Human1.38809414
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36159592
78STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35982283
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35359205
80RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34838229
81TP63_19390658_ChIP-ChIP_HaCaT_Human1.34537236
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31295447
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31135401
84TTF2_22483619_ChIP-Seq_HELA_Human1.30186282
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27324241
86* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26825957
87* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26112983
88EGR1_19374776_ChIP-ChIP_THP-1_Human1.22786767
89RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.21147869
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.18715960
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16379997
92* DCP1A_22483619_ChIP-Seq_HELA_Human1.14832573
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.14658480
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14243873
95* KDM5A_27292631_Chip-Seq_BREAST_Human1.13948926
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.13732457
97ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12583687
98CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12532646
99* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11708007
100WT1_19549856_ChIP-ChIP_CCG9911_Human1.11590455
101CIITA_25753668_ChIP-Seq_RAJI_Human1.09768720
102XRN2_22483619_ChIP-Seq_HELA_Human1.07746213
103FLI1_27457419_Chip-Seq_LIVER_Mouse1.07436981
104AR_20517297_ChIP-Seq_VCAP_Human1.07121330
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05839329
106FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.04769845
107EZH2_27294783_Chip-Seq_NPCs_Mouse1.04678684
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.04445049
109SOX17_20123909_ChIP-Seq_XEN_Mouse1.04219849
110TAF15_26573619_Chip-Seq_HEK293_Human1.03909900
111RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02891877
112FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.02676225
113IRF1_19129219_ChIP-ChIP_H3396_Human1.02027926
114MYC_18940864_ChIP-ChIP_HL60_Human1.01985947
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00653606
116GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00503086
117HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.00402119
118MYB_26560356_Chip-Seq_TH2_Human1.00030088
119PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99794968
120GATA3_26560356_Chip-Seq_TH2_Human0.99755140
121MYB_26560356_Chip-Seq_TH1_Human0.97701644
122PU_27001747_Chip-Seq_BMDM_Mouse0.97462402
123* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97202275
124GATA2_21666600_ChIP-Seq_HMVEC_Human0.97168837
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.95969028
126MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95284304
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.94571613
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94395472
129PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94349985
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93136474
131CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.92618545
132SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92075221
133P53_22387025_ChIP-Seq_ESCs_Mouse0.91713690
134FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.91180879
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90992582
136PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90772162
137GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89288624
138SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89029668
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88512743
140CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.88423105
141SALL4_22934838_ChIP-ChIP_CD34+_Human0.88420546
142CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85409646
143ELF5_23300383_ChIP-Seq_T47D_Human0.82472410
144PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81930160
145SALL4_18804426_ChIP-ChIP_XEN_Mouse0.78442272
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.77692848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.80335233
2MP0003111_abnormal_nucleus_morphology3.52072341
3MP0004957_abnormal_blastocyst_morpholog3.28197992
4MP0001835_abnormal_antigen_presentation3.23102060
5MP0000569_abnormal_digit_pigmentation3.19975480
6MP0003195_calcinosis3.18359372
7MP0003077_abnormal_cell_cycle3.04618069
8MP0010352_gastrointestinal_tract_polyps3.02307374
9MP0005058_abnormal_lysosome_morphology2.64677068
10MP0002139_abnormal_hepatobiliary_system2.61485879
11MP0010386_abnormal_urinary_bladder2.60144407
12MP0003221_abnormal_cardiomyocyte_apopto2.47977339
13MP0008932_abnormal_embryonic_tissue2.39952457
14MP0005360_urolithiasis2.39888205
15MP0008875_abnormal_xenobiotic_pharmacok2.36779583
16MP0009697_abnormal_copulation2.27834234
17MP0002419_abnormal_innate_immunity2.21480506
18MP0003718_maternal_effect2.20904227
19MP0001853_heart_inflammation2.20870231
20MP0003172_abnormal_lysosome_physiology2.16511302
21MP0005365_abnormal_bile_salt1.97712507
22MP0005670_abnormal_white_adipose1.93905038
23MP0003436_decreased_susceptibility_to1.92971881
24MP0005464_abnormal_platelet_physiology1.92573457
25MP0003890_abnormal_embryonic-extraembry1.90891148
26MP0002148_abnormal_hypersensitivity_rea1.89833958
27MP0005085_abnormal_gallbladder_physiolo1.89726338
28MP0000350_abnormal_cell_proliferation1.89435039
29MP0003724_increased_susceptibility_to1.85922615
30MP0009785_altered_susceptibility_to1.85604017
31MP0000015_abnormal_ear_pigmentation1.84664432
32MP0003806_abnormal_nucleotide_metabolis1.80060612
33MP0003656_abnormal_erythrocyte_physiolo1.76078443
34MP0009764_decreased_sensitivity_to1.74641289
35MP0001730_embryonic_growth_arrest1.72877406
36MP0001764_abnormal_homeostasis1.72078577
37MP0005025_abnormal_response_to1.70940721
38MP0010234_abnormal_vibrissa_follicle1.66543778
39MP0002452_abnormal_antigen_presenting1.64552035
40MP0002396_abnormal_hematopoietic_system1.61437128
41MP0003252_abnormal_bile_duct1.60894168
42MP0001800_abnormal_humoral_immune1.60713117
43MP0001790_abnormal_immune_system1.59634999
44MP0005387_immune_system_phenotype1.59634999
45MP0000013_abnormal_adipose_tissue1.59135122
46MP0003303_peritoneal_inflammation1.57736365
47MP0004019_abnormal_vitamin_homeostasis1.56223146
48MP0005000_abnormal_immune_tolerance1.54995114
49MP0005174_abnormal_tail_pigmentation1.54918280
50MP0005671_abnormal_response_to1.54649839
51MP0004233_abnormal_muscle_weight1.53086478
52MP0002132_abnormal_respiratory_system1.52607451
53MP0001529_abnormal_vocalization1.51393356
54MP0002723_abnormal_immune_serum1.51376069
55MP0004510_myositis1.48515030
56MP0000313_abnormal_cell_death1.46417778
57MP0010307_abnormal_tumor_latency1.45259409
58MP0002420_abnormal_adaptive_immunity1.44168886
59MP0005647_abnormal_sex_gland1.43796077
60MP0001819_abnormal_immune_cell1.43765421
61MP0004808_abnormal_hematopoietic_stem1.41214852
62MP0006292_abnormal_olfactory_placode1.40047708
63MP0001986_abnormal_taste_sensitivity1.38646725
64MP0003950_abnormal_plasma_membrane1.38633437
65MP0008469_abnormal_protein_level1.37940319
66MP0005451_abnormal_body_composition1.34495380
67MP0004264_abnormal_extraembryonic_tissu1.33586828
68MP0008057_abnormal_DNA_replication1.32917021
69MP0002138_abnormal_hepatobiliary_system1.28852580
70MP0003186_abnormal_redox_activity1.28637065
71MP0000465_gastrointestinal_hemorrhage1.27140202
72MP0004782_abnormal_surfactant_physiolog1.26945133
73MP0002693_abnormal_pancreas_physiology1.26666817
74MP0002876_abnormal_thyroid_physiology1.24961021
75MP0001293_anophthalmia1.24513279
76MP0005646_abnormal_pituitary_gland1.24024345
77MP0001672_abnormal_embryogenesis/_devel1.23735463
78MP0005380_embryogenesis_phenotype1.23735463
79MP0001697_abnormal_embryo_size1.22054307
80MP0001845_abnormal_inflammatory_respons1.22024872
81MP0008058_abnormal_DNA_repair1.21188406
82MP0002877_abnormal_melanocyte_morpholog1.20492411
83MP0002398_abnormal_bone_marrow1.17153296
84MP0001186_pigmentation_phenotype1.16195051
85MP0004185_abnormal_adipocyte_glucose1.15700358
86MP0000371_diluted_coat_color1.15544114
87MP0001188_hyperpigmentation1.15538501
88MP0000716_abnormal_immune_system1.13931064
89MP0002928_abnormal_bile_duct1.13889222
90MP0001879_abnormal_lymphatic_vessel1.11784908
91MP0000358_abnormal_cell_content/1.11399762
92MP0004197_abnormal_fetal_growth/weight/1.11113045
93MP0006082_CNS_inflammation1.10882935
94MP0002095_abnormal_skin_pigmentation1.09215313
95MP0003943_abnormal_hepatobiliary_system1.09013455
96MP0002080_prenatal_lethality1.08602598
97MP0008260_abnormal_autophagy1.08497719
98MP0000538_abnormal_urinary_bladder1.07141796
99MP0006035_abnormal_mitochondrial_morpho1.05925354
100MP0002277_abnormal_respiratory_mucosa1.05640918
101MP0003646_muscle_fatigue1.05420328
102MP0002332_abnormal_exercise_endurance1.04845132
103MP0005379_endocrine/exocrine_gland_phen1.04794755
104MP0000689_abnormal_spleen_morphology1.04723463
105MP0003191_abnormal_cellular_cholesterol1.02968026
106MP0001533_abnormal_skeleton_physiology1.02792287
107MP0000516_abnormal_urinary_system1.00834449
108MP0005367_renal/urinary_system_phenotyp1.00834449
109MP0003763_abnormal_thymus_physiology1.00613559
110MP0002429_abnormal_blood_cell1.00450612
111MP0003984_embryonic_growth_retardation1.00113653
112MP0005266_abnormal_metabolism0.99808291
113MP0004215_abnormal_myocardial_fiber0.98983111
114MP0003448_altered_tumor_morphology0.98547550
115MP0002088_abnormal_embryonic_growth/wei0.96420065
116MP0004147_increased_porphyrin_level0.95558370
117MP0001666_abnormal_nutrient_absorption0.95557928
118MP0008007_abnormal_cellular_replicative0.94668284
119MP0006054_spinal_hemorrhage0.94411578
120MP0002084_abnormal_developmental_patter0.93955612
121MP0010329_abnormal_lipoprotein_level0.93283919
122MP0010094_abnormal_chromosome_stability0.93263018
123MP0000609_abnormal_liver_physiology0.93113655
124MP0002009_preneoplasia0.92495364
125MP0003693_abnormal_embryo_hatching0.92124646
126MP0002796_impaired_skin_barrier0.91563910
127MP0002405_respiratory_system_inflammati0.90633415
128MP0008789_abnormal_olfactory_epithelium0.90020227
129MP0003787_abnormal_imprinting0.89691998
130MP0002019_abnormal_tumor_incidence0.89250486
131MP0001545_abnormal_hematopoietic_system0.89173259
132MP0005397_hematopoietic_system_phenotyp0.89173259
133MP0003786_premature_aging0.87626830
134MP0005319_abnormal_enzyme/_coenzyme0.87457657
135MP0003828_pulmonary_edema0.87447433
136MP0000490_abnormal_crypts_of0.87414722
137MP0002638_abnormal_pupillary_reflex0.86600129
138MP0005084_abnormal_gallbladder_morpholo0.86347696
139MP0002075_abnormal_coat/hair_pigmentati0.86187252
140MP0003453_abnormal_keratinocyte_physiol0.85320972
141MP0005623_abnormal_meninges_morphology0.84415524
142MP0006036_abnormal_mitochondrial_physio0.83627356
143MP0000598_abnormal_liver_morphology0.83174667
144MP0005645_abnormal_hypothalamus_physiol0.83111060
145MP0005220_abnormal_exocrine_pancreas0.82495589
146MP0002722_abnormal_immune_system0.82082741
147MP0004043_abnormal_pH_regulation0.81524448
148MP0003941_abnormal_skin_development0.81282896
149MP0000685_abnormal_immune_system0.80616328
150MP0002085_abnormal_embryonic_tissue0.80414190
151MP0005384_cellular_phenotype0.79854507
152MP0002006_tumorigenesis0.79482520
153MP0001243_abnormal_dermal_layer0.78420537
154MP0005621_abnormal_cell_physiology0.77605882
155MP0000749_muscle_degeneration0.77284383
156MP0001915_intracranial_hemorrhage0.76310733
157MP0001727_abnormal_embryo_implantation0.76086538
158MP0002269_muscular_atrophy0.75751523
159MP0005395_other_phenotype0.75097922
160MP0001216_abnormal_epidermal_layer0.74301262
161MP0010368_abnormal_lymphatic_system0.70190303
162MP0002102_abnormal_ear_morphology0.69730777
163MP0002086_abnormal_extraembryonic_tissu0.69066191
164MP0002092_abnormal_eye_morphology0.68152859
165MP0005501_abnormal_skin_physiology0.66267520
166MP0002233_abnormal_nose_morphology0.65998356
167MP0000703_abnormal_thymus_morphology0.65548996
168MP0005376_homeostasis/metabolism_phenot0.64949537
169MP0009765_abnormal_xenobiotic_induced0.62780358
170MP0009115_abnormal_fat_cell0.60804417

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.01434581
2Joint hemorrhage (HP:0005261)3.85728904
3Papillary thyroid carcinoma (HP:0002895)3.77175813
4Recurrent gram-negative bacterial infections (HP:0005420)3.66221979
5Reduced antithrombin III activity (HP:0001976)3.64875741
6Chromsome breakage (HP:0040012)3.59048192
7Recurrent bacterial skin infections (HP:0005406)3.58476429
8Recurrent abscess formation (HP:0002722)3.54587697
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.52832836
10Renal cortical cysts (HP:0000803)3.37263143
11Mutism (HP:0002300)3.36585089
12Medulloblastoma (HP:0002885)3.30358407
13Abnormality of chromosome stability (HP:0003220)3.24730780
14Disinhibition (HP:0000734)3.18066717
15Eczematoid dermatitis (HP:0000976)3.15756762
16Gonadotropin excess (HP:0000837)3.11685548
17Cortical dysplasia (HP:0002539)3.09086470
18Neoplasm of the adrenal gland (HP:0100631)3.02750101
19Neoplasm of the adrenal cortex (HP:0100641)3.01574250
20Hypoglycemic coma (HP:0001325)2.98723153
21Thyroid carcinoma (HP:0002890)2.96490601
22Abnormality of the intrinsic pathway (HP:0010989)2.93263480
23Rhabdomyosarcoma (HP:0002859)2.91800146
24Hypothermia (HP:0002045)2.79550543
25Nemaline bodies (HP:0003798)2.78923823
26Abnormality of the preputium (HP:0100587)2.75809782
27Limb hypertonia (HP:0002509)2.73421056
28Generalized aminoaciduria (HP:0002909)2.70300494
29Vacuolated lymphocytes (HP:0001922)2.68323099
30Meckel diverticulum (HP:0002245)2.67118200
31Exercise-induced muscle cramps (HP:0003710)2.66413058
32Hypoglycemic seizures (HP:0002173)2.66054016
33Type I transferrin isoform profile (HP:0003642)2.64356752
34Abnormal lung lobation (HP:0002101)2.61568790
35Abnormality of fatty-acid metabolism (HP:0004359)2.58989613
36Agnosia (HP:0010524)2.58573422
37Increased serum pyruvate (HP:0003542)2.56476838
38Multiple enchondromatosis (HP:0005701)2.56038332
39Abnormality of DNA repair (HP:0003254)2.51140877
40Increased neuronal autofluorescent lipopigment (HP:0002074)2.50043752
41Embryonal renal neoplasm (HP:0011794)2.49051285
42Dyschromatopsia (HP:0007641)2.48878957
43Abnormality of the common coagulation pathway (HP:0010990)2.45456262
44Curly hair (HP:0002212)2.44994575
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.44420146
46Abnormality of the ileum (HP:0001549)2.43527000
47Retrobulbar optic neuritis (HP:0100654)2.43132152
48Optic neuritis (HP:0100653)2.43132152
49Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41090185
50Colon cancer (HP:0003003)2.40643421
51Nephroblastoma (Wilms tumor) (HP:0002667)2.40214891
52Thrombocytosis (HP:0001894)2.39235321
53Abnormality of macrophages (HP:0004311)2.39031755
54Muscle fiber inclusion bodies (HP:0100299)2.36578836
55Prostate neoplasm (HP:0100787)2.34267850
56Periodontitis (HP:0000704)2.34132487
57Orchitis (HP:0100796)2.31651733
58Abnormality of the anterior horn cell (HP:0006802)2.30503800
59Degeneration of anterior horn cells (HP:0002398)2.30503800
60Myositis (HP:0100614)2.29824919
61Abnormality of lateral ventricle (HP:0030047)2.27867147
62Neoplasm of the colon (HP:0100273)2.27686648
63Aplastic anemia (HP:0001915)2.25101754
64Capillary hemangiomas (HP:0005306)2.25098500
65Pigmentary retinal degeneration (HP:0001146)2.22081706
66IgM deficiency (HP:0002850)2.21167519
67Increased cerebral lipofuscin (HP:0011813)2.20416173
68Nausea (HP:0002018)2.20279832
69Gingivitis (HP:0000230)2.19583171
70Oral leukoplakia (HP:0002745)2.19395419
71Entropion (HP:0000621)2.18173523
72Abnormality of the left ventricular outflow tract (HP:0011103)2.17249444
73Subaortic stenosis (HP:0001682)2.17249444
74Abnormality of glycolysis (HP:0004366)2.16895278
75Loss of speech (HP:0002371)2.16442056
76Abnormality of the fetal cardiovascular system (HP:0010948)2.16412597
77Abnormal umbilical cord blood vessels (HP:0011403)2.16412597
78Single umbilical artery (HP:0001195)2.16412597
79Hypoplasia of the thymus (HP:0000778)2.16241427
80Symptomatic seizures (HP:0011145)2.15351168
81Microglossia (HP:0000171)2.15066468
82Cystic hygroma (HP:0000476)2.14853028
83Proximal tubulopathy (HP:0000114)2.14349754
84Small intestinal stenosis (HP:0012848)2.13625366
85Duodenal stenosis (HP:0100867)2.13625366
86Abnormality of the renal cortex (HP:0011035)2.12535672
87Mediastinal lymphadenopathy (HP:0100721)2.11856715
88Abnormality of aromatic amino acid family metabolism (HP:0004338)2.11829899
89Increased hepatocellular lipid droplets (HP:0006565)2.11499843
90Sensorimotor neuropathy (HP:0007141)2.09313892
91Abnormal hair whorl (HP:0010721)2.08876305
92Deep philtrum (HP:0002002)2.07716684
93Basal ganglia calcification (HP:0002135)2.07132934
94Recurrent skin infections (HP:0001581)2.03473261
95Palpitations (HP:0001962)2.03191105
963-Methylglutaconic aciduria (HP:0003535)2.02952243
97Acute necrotizing encephalopathy (HP:0006965)2.02299305
98Acute myeloid leukemia (HP:0004808)2.01500772
99Type 2 muscle fiber atrophy (HP:0003554)2.01238397
100Impaired platelet aggregation (HP:0003540)2.01182425
101Abnormal platelet function (HP:0011869)2.01182425
102Syringomyelia (HP:0003396)2.00601324
103Spinal cord lesions (HP:0100561)2.00601324
104Abnormality of methionine metabolism (HP:0010901)2.00428985
105Freckling (HP:0001480)2.00264768
106Hyperinsulinemic hypoglycemia (HP:0000825)1.99657521
107Osteomyelitis (HP:0002754)1.99217667
108Abnormality of the prostate (HP:0008775)1.98235997
109Menorrhagia (HP:0000132)1.97889281
110Gingival bleeding (HP:0000225)1.97871772
111Progressive muscle weakness (HP:0003323)1.96933597
112Encephalitis (HP:0002383)1.96637667
113Volvulus (HP:0002580)1.96404149
114Keratoconjunctivitis sicca (HP:0001097)1.95504748
115Facial hemangioma (HP:0000329)1.95265220
116Upper motor neuron abnormality (HP:0002127)1.94810114
117Shoulder girdle muscle weakness (HP:0003547)1.94569985
118Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.94155371
119Abnormal protein N-linked glycosylation (HP:0012347)1.94155371
120Abnormal protein glycosylation (HP:0012346)1.94155371
121Abnormal glycosylation (HP:0012345)1.94155371
122Secondary amenorrhea (HP:0000869)1.93347111
123Hypobetalipoproteinemia (HP:0003563)1.93199911
124Constricted visual fields (HP:0001133)1.91789173
125Recurrent fungal infections (HP:0002841)1.91648666
126Abnormality of alanine metabolism (HP:0010916)1.91423586
127Hyperalaninemia (HP:0003348)1.91423586
128Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.91423586
129Premature ovarian failure (HP:0008209)1.91005371
130Microvesicular hepatic steatosis (HP:0001414)1.90795001
131Abnormality of urine glucose concentration (HP:0011016)1.89983534
132Glycosuria (HP:0003076)1.89983534
133Melanoma (HP:0002861)1.89922531
134Neoplasm of the small intestine (HP:0100833)1.89783985
135Retinal atrophy (HP:0001105)1.88807949
136Myelodysplasia (HP:0002863)1.87856099
137Neuroblastoma (HP:0003006)1.87646514
138Primitive neuroectodermal tumor (HP:0030065)1.87646514
139Neuroblastic tumors (HP:0004376)1.87646514
140Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.87646514
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87315655
142Progressive external ophthalmoplegia (HP:0000590)1.87115483
143Viral hepatitis (HP:0006562)1.86884313
144Short middle phalanx of the 5th finger (HP:0004220)1.86526466
145Posterior subcapsular cataract (HP:0007787)1.85585104
146Cutaneous melanoma (HP:0012056)1.85243243
147Keratitis (HP:0000491)1.84338166
148Epistaxis (HP:0000421)1.83635337
149Subacute progressive viral hepatitis (HP:0006572)1.82589004
150Acute encephalopathy (HP:0006846)1.82535326
151Abnormality of the septum pellucidum (HP:0007375)1.82534742
152Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.82176639
153Obstructive lung disease (HP:0006536)1.82088405
154Chronic obstructive pulmonary disease (HP:0006510)1.82088405
155Autoamputation (HP:0001218)1.81408702
156Spontaneous hematomas (HP:0007420)1.81159813
157Alveolar cell carcinoma (HP:0006519)1.80634200
158Inappropriate behavior (HP:0000719)1.80276417
159Abnormal foot bone ossification (HP:0010675)1.80023894
160Prolonged bleeding time (HP:0003010)1.79605422
161Biliary tract neoplasm (HP:0100574)1.77963562
162Neuroendocrine neoplasm (HP:0100634)1.77963254
163Fair hair (HP:0002286)1.76511061
164Vasculitis (HP:0002633)1.76330865
165Lipid accumulation in hepatocytes (HP:0006561)1.75413048
166Meningitis (HP:0001287)1.74196146
167Apathy (HP:0000741)1.74084342
168Uterine neoplasm (HP:0010784)1.73790824
169Hepatosplenomegaly (HP:0001433)1.72722629
170Recurrent sinusitis (HP:0011108)1.72584175
171Osteomalacia (HP:0002749)1.72111130
172Abnormality of the basal ganglia (HP:0002134)1.71427363
173Abnormal mitochondria in muscle tissue (HP:0008316)1.71336422
174Tetany (HP:0001281)1.71129193
175Dysostosis multiplex (HP:0000943)1.71076046
176B lymphocytopenia (HP:0010976)1.69855030
177Abnormality of B cell number (HP:0010975)1.69855030
178Renal Fanconi syndrome (HP:0001994)1.69734199
179Keratoconjunctivitis (HP:0001096)1.69469354
180Abnormality of aspartate family amino acid metabolism (HP:0010899)1.69139754
181Cerebral palsy (HP:0100021)1.67994051
182Hepatic necrosis (HP:0002605)1.67603579
183Progressive macrocephaly (HP:0004481)1.66783824

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.60114294
2TAOK33.46186724
3IRAK43.15450707
4PBK3.08748627
5TRIM283.07708213
6IRAK32.91490790
7CDC72.75988705
8KIT2.72644863
9TTK2.42512353
10SGK22.22685004
11NEK12.21657286
12STK162.17161787
13PLK42.13353641
14RIPK42.12758293
15ZAK2.12119750
16WEE12.05277702
17TEC2.03304544
18VRK22.02641114
19INSRR2.00388966
20MAP2K31.99706320
21MAP3K31.83252954
22ERBB31.82342698
23MAP3K141.77701518
24AKT31.76839446
25BRD41.72309199
26NEK91.70056357
27MAP2K71.62346275
28NME21.59707579
29TNIK1.52297177
30PASK1.50947876
31TGFBR21.47116149
32YES11.45614728
33BCR1.44393467
34SGK31.44007045
35STK31.42965930
36STK101.42929973
37TXK1.38096506
38TYK21.37526554
39STK38L1.36113229
40CAMKK21.35144031
41BCKDK1.34239675
42BRSK21.33332542
43BTK1.32518632
44SYK1.29378086
45EIF2AK21.26870483
46PLK11.21393407
47CSNK1G11.19644274
48MST41.16480739
49MKNK21.15287859
50TRPM71.13102729
51MAP3K121.12931770
52VRK11.11579648
53ERBB41.10145904
54BLK1.09863389
55SIK11.07642242
56TAF11.07524860
57SIK21.07293437
58CLK11.06899133
59BMPR21.05418279
60NUAK11.03365036
61MAP4K11.02394028
62FLT30.99358229
63CASK0.98887750
64TBK10.96196901
65TESK20.93367238
66CHEK20.92975120
67LYN0.92092056
68ACVR1B0.91870498
69SGK2230.91547691
70SGK4940.91547691
71CSNK1G30.91474820
72BMPR1B0.91401837
73MOS0.91351599
74JAK30.89414769
75PIK3CG0.89388602
76PDK30.89033946
77PDK40.89033946
78RPS6KA40.87989880
79MAP3K80.83088568
80EIF2AK30.82527008
81FRK0.82216217
82ZAP700.80524246
83MAP3K100.79681176
84ATM0.78794423
85PLK20.77945528
86SRPK10.77393344
87OBSCN0.76955010
88MARK30.76659172
89CSNK1A1L0.76281251
90ADRBK20.75942749
91CCNB10.75371253
92CHUK0.75308151
93IKBKB0.74453299
94PIM10.73325438
95EIF2AK10.73269317
96CHEK10.73226888
97TSSK60.71911860
98MKNK10.71586230
99KSR10.68991529
100CSNK1G20.68461529
101STK240.66758411
102BRSK10.66117505
103GRK70.65313592
104TAOK20.63865741
105MYLK0.63711309
106IKBKE0.62748179
107PAK40.62114455
108JAK10.61677388
109TNK20.61370172
110PIM20.59248965
111AURKB0.56372126
112CDK90.55987423
113PLK30.53841360
114BRAF0.53724867
115WNK30.52840047
116CDK70.51724072
117PRPF4B0.51489757
118ATR0.51110592
119CSF1R0.50729814
120MELK0.50640055
121DYRK30.50256178
122BUB10.48809611
123TGFBR10.47505751
124CDK60.47138782
125PRKCD0.46095594
126RPS6KA60.45345445
127RPS6KL10.44989710
128RPS6KC10.44989710
129STK40.43818955
130FES0.42703881
131MAP3K50.40821343
132ARAF0.40145867
133CDK30.39828315
134CSNK2A10.39676734
135MATK0.39378300
136RPS6KB10.38470793
137LATS10.37785535
138MAPK130.36722497
139KDR0.35850953
140HCK0.35831733
141MAP3K130.34847163
142PRKCE0.34731771
143IGF1R0.34191821
144MAP3K90.30007919
145AKT20.28928700
146CSNK2A20.28509873
147RAF10.27885408
148CDK20.25792630
149CDK10.23917655
150DAPK10.23327326
151MAP3K40.23100189

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.49606752
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.13460821
3Protein export_Homo sapiens_hsa030602.99973093
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.68154697
5RNA transport_Homo sapiens_hsa030132.43689875
6Spliceosome_Homo sapiens_hsa030402.43321930
7Cell cycle_Homo sapiens_hsa041102.42719146
8Proteasome_Homo sapiens_hsa030502.22483950
9Caffeine metabolism_Homo sapiens_hsa002322.19082584
10Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07297538
11Sulfur metabolism_Homo sapiens_hsa009201.96819886
12Staphylococcus aureus infection_Homo sapiens_hsa051501.92070572
13Complement and coagulation cascades_Homo sapiens_hsa046101.83866531
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.82360418
15Cysteine and methionine metabolism_Homo sapiens_hsa002701.79233531
16Steroid biosynthesis_Homo sapiens_hsa001001.74988019
17NF-kappa B signaling pathway_Homo sapiens_hsa040641.70879038
18Fatty acid degradation_Homo sapiens_hsa000711.68447437
19Phenylalanine metabolism_Homo sapiens_hsa003601.66341682
20Leishmaniasis_Homo sapiens_hsa051401.63042486
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62118686
22Tyrosine metabolism_Homo sapiens_hsa003501.61541470
23Homologous recombination_Homo sapiens_hsa034401.56323969
24Nucleotide excision repair_Homo sapiens_hsa034201.55753963
25SNARE interactions in vesicular transport_Homo sapiens_hsa041301.53736434
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48490739
27Legionellosis_Homo sapiens_hsa051341.47365209
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46116646
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.45021813
30Lysosome_Homo sapiens_hsa041421.44592525
31Selenocompound metabolism_Homo sapiens_hsa004501.43384110
32Peroxisome_Homo sapiens_hsa041461.40658153
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39603200
34Fatty acid elongation_Homo sapiens_hsa000621.38431146
35mRNA surveillance pathway_Homo sapiens_hsa030151.37982793
36Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37226349
37Non-homologous end-joining_Homo sapiens_hsa034501.33897699
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.32683137
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.32577156
40Histidine metabolism_Homo sapiens_hsa003401.31894877
41Chemical carcinogenesis_Homo sapiens_hsa052041.31619813
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.29360620
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26725602
44Folate biosynthesis_Homo sapiens_hsa007901.26043071
45Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25660634
46Regulation of autophagy_Homo sapiens_hsa041401.25256800
47RNA degradation_Homo sapiens_hsa030181.23244367
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18929592
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.18170562
50Phagosome_Homo sapiens_hsa041451.18151828
51One carbon pool by folate_Homo sapiens_hsa006701.14957180
52Starch and sucrose metabolism_Homo sapiens_hsa005001.14501912
53Tryptophan metabolism_Homo sapiens_hsa003801.13602759
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.12354790
55Measles_Homo sapiens_hsa051621.10296112
56DNA replication_Homo sapiens_hsa030301.09834392
57RNA polymerase_Homo sapiens_hsa030201.08619010
58Herpes simplex infection_Homo sapiens_hsa051681.08458579
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08451526
60Hematopoietic cell lineage_Homo sapiens_hsa046401.07189989
61Base excision repair_Homo sapiens_hsa034101.06525842
62Oxidative phosphorylation_Homo sapiens_hsa001901.06470046
63Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03425762
64Collecting duct acid secretion_Homo sapiens_hsa049661.02368281
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.02342246
66Pertussis_Homo sapiens_hsa051331.00946939
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.98516747
68beta-Alanine metabolism_Homo sapiens_hsa004100.98410226
69N-Glycan biosynthesis_Homo sapiens_hsa005100.98112353
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.97586820
71Rheumatoid arthritis_Homo sapiens_hsa053230.97039592
72Thyroid cancer_Homo sapiens_hsa052160.96579045
73Circadian rhythm_Homo sapiens_hsa047100.95231391
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.94924122
75Oocyte meiosis_Homo sapiens_hsa041140.93931282
76Pyrimidine metabolism_Homo sapiens_hsa002400.93503880
77Other glycan degradation_Homo sapiens_hsa005110.92849442
78Fanconi anemia pathway_Homo sapiens_hsa034600.91777849
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90542946
80Osteoclast differentiation_Homo sapiens_hsa043800.88284441
81Mismatch repair_Homo sapiens_hsa034300.87479303
82ABC transporters_Homo sapiens_hsa020100.84738371
83Shigellosis_Homo sapiens_hsa051310.84188766
84Tuberculosis_Homo sapiens_hsa051520.83865334
85Influenza A_Homo sapiens_hsa051640.82400435
86Antigen processing and presentation_Homo sapiens_hsa046120.82029796
87Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80599791
88Propanoate metabolism_Homo sapiens_hsa006400.79541482
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76609390
90Parkinsons disease_Homo sapiens_hsa050120.76463184
91Carbon metabolism_Homo sapiens_hsa012000.74783816
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74499585
93Alzheimers disease_Homo sapiens_hsa050100.73765463
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73076294
95Galactose metabolism_Homo sapiens_hsa000520.72964384
96Hepatitis B_Homo sapiens_hsa051610.72048101
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71834542
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71797380
99Primary immunodeficiency_Homo sapiens_hsa053400.71572706
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.68717022
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67591226
102Retinol metabolism_Homo sapiens_hsa008300.65386678
103Basal transcription factors_Homo sapiens_hsa030220.65295989
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.63771565
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.60827942
106TGF-beta signaling pathway_Homo sapiens_hsa043500.60550449
107Viral carcinogenesis_Homo sapiens_hsa052030.58833638
108Glutathione metabolism_Homo sapiens_hsa004800.58122183
109Vitamin digestion and absorption_Homo sapiens_hsa049770.57068254
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55061339
111Malaria_Homo sapiens_hsa051440.53935247
112Renin-angiotensin system_Homo sapiens_hsa046140.52567635
113Epstein-Barr virus infection_Homo sapiens_hsa051690.51939649
114MicroRNAs in cancer_Homo sapiens_hsa052060.51761359
115Pyruvate metabolism_Homo sapiens_hsa006200.50513912
116Sphingolipid metabolism_Homo sapiens_hsa006000.50146688
117TNF signaling pathway_Homo sapiens_hsa046680.50127825
118Biosynthesis of amino acids_Homo sapiens_hsa012300.50037420
119Huntingtons disease_Homo sapiens_hsa050160.49912299
120Viral myocarditis_Homo sapiens_hsa054160.49864706
121Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49717848
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48412533
123Prostate cancer_Homo sapiens_hsa052150.47958422
124B cell receptor signaling pathway_Homo sapiens_hsa046620.46770664
125HTLV-I infection_Homo sapiens_hsa051660.46046859
126p53 signaling pathway_Homo sapiens_hsa041150.45851085
127Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45062100
128Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45008069
129Purine metabolism_Homo sapiens_hsa002300.44687968
130Bladder cancer_Homo sapiens_hsa052190.44242360
131Adherens junction_Homo sapiens_hsa045200.44087665
132Pentose phosphate pathway_Homo sapiens_hsa000300.37870371
133Allograft rejection_Homo sapiens_hsa053300.37793123
134Asthma_Homo sapiens_hsa053100.36854951
135Apoptosis_Homo sapiens_hsa042100.32130875
136Chronic myeloid leukemia_Homo sapiens_hsa052200.30945485
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28898844
138Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.27761666
139Salmonella infection_Homo sapiens_hsa051320.26934641
140African trypanosomiasis_Homo sapiens_hsa051430.26299157
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25918034
142Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25132055

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