FAM177B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1diacylglycerol metabolic process (GO:0046339)5.56573256
2maintenance of gastrointestinal epithelium (GO:0030277)4.97152525
3regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)4.73015361
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.95302598
5L-fucose catabolic process (GO:0042355)3.95099659
6fucose catabolic process (GO:0019317)3.95099659
7L-fucose metabolic process (GO:0042354)3.95099659
8macrophage activation involved in immune response (GO:0002281)3.80018559
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.71141438
10angiotensin maturation (GO:0002003)3.70730236
11fatty acid derivative transport (GO:1901571)3.69861529
12icosanoid transport (GO:0071715)3.69861529
13negative regulation of transcription by competitive promoter binding (GO:0010944)3.68123260
14glycerol metabolic process (GO:0006071)3.59516065
15digestion (GO:0007586)3.50043940
16response to folic acid (GO:0051593)3.39757326
17modulation by symbiont of host immune response (GO:0052553)3.38427702
18positive regulation by symbiont of host defense response (GO:0052509)3.38427702
19modulation by symbiont of host defense response (GO:0052031)3.38427702
20modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38427702
21modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38427702
22positive regulation by organism of defense response of other organism involved in symbiotic interact3.38427702
23microglial cell activation (GO:0001774)3.36785120
24cellular ketone body metabolic process (GO:0046950)3.28801901
25icosanoid secretion (GO:0032309)3.27770676
26arachidonic acid secretion (GO:0050482)3.27770676
27phosphatidylinositol acyl-chain remodeling (GO:0036149)3.26512742
28epithelial structure maintenance (GO:0010669)3.18287132
29immunoglobulin mediated immune response (GO:0016064)3.17892493
30alditol metabolic process (GO:0019400)3.15473673
31regulation of interferon-beta biosynthetic process (GO:0045357)3.12615055
32negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.11557988
33negative regulation of T-helper cell differentiation (GO:0045623)3.11557988
34antigen processing and presentation of endogenous antigen (GO:0019883)3.05746508
35heme transport (GO:0015886)3.03708637
36digestive system process (GO:0022600)3.02542039
37vitamin A metabolic process (GO:0006776)3.01240610
38regulation of guanylate cyclase activity (GO:0031282)2.99536135
39regulation of systemic arterial blood pressure by hormone (GO:0001990)2.99495280
40regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.99495280
41endocrine process (GO:0050886)2.99495280
42regulation of T-helper 2 cell differentiation (GO:0045628)2.96991190
43histamine secretion (GO:0001821)2.95045817
44post-embryonic morphogenesis (GO:0009886)2.94566816
45regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93118944
46positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.91997984
47antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86947652
48mitochondrial calcium ion transport (GO:0006851)2.85712533
49I-kappaB phosphorylation (GO:0007252)2.85660129
50intestinal absorption (GO:0050892)2.85626961
51neutrophil activation involved in immune response (GO:0002283)2.85249403
52macrophage activation (GO:0042116)2.83944837
53low-density lipoprotein particle remodeling (GO:0034374)2.82696653
54negative regulation of glycoprotein biosynthetic process (GO:0010561)2.82159204
55ketone body metabolic process (GO:1902224)2.81773653
56auditory receptor cell differentiation (GO:0042491)2.81449675
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.81367601
58negative regulation of digestive system process (GO:0060457)2.79007315
59B cell receptor signaling pathway (GO:0050853)2.75456723
60leukocyte migration involved in inflammatory response (GO:0002523)2.72360129
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.70865310
62bile acid and bile salt transport (GO:0015721)2.69797035
63negative regulation of gluconeogenesis (GO:0045721)2.69301088
64superoxide anion generation (GO:0042554)2.66279211
65cellular response to ethanol (GO:0071361)2.65915102
66receptor guanylyl cyclase signaling pathway (GO:0007168)2.63205570
67G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60609621
68lipoprotein transport (GO:0042953)2.59568878
69transcytosis (GO:0045056)2.57851301
70respiratory burst (GO:0045730)2.55960974
71myeloid cell activation involved in immune response (GO:0002275)2.55316767
72adenosine receptor signaling pathway (GO:0001973)2.55101171
73O-glycan processing (GO:0016266)2.54584912
74positive regulation of gamma-delta T cell activation (GO:0046645)2.53985937
75antimicrobial humoral response (GO:0019730)2.53908777
76production of molecular mediator involved in inflammatory response (GO:0002532)2.53610807
77drug transport (GO:0015893)2.52099043
78high-density lipoprotein particle remodeling (GO:0034375)2.51549816
79antibacterial humoral response (GO:0019731)2.50607416
80regulation of myeloid leukocyte mediated immunity (GO:0002886)2.48455110
81regulation of antigen processing and presentation (GO:0002577)2.47776573
82positive regulation of guanylate cyclase activity (GO:0031284)2.45471542
83histamine transport (GO:0051608)2.44665072
84purinergic nucleotide receptor signaling pathway (GO:0035590)2.44066843
85neurotransmitter catabolic process (GO:0042135)2.43659827
86protein targeting to Golgi (GO:0000042)2.43393212
87drug transmembrane transport (GO:0006855)2.42677939
88regulation of T-helper 1 cell differentiation (GO:0045625)2.41509000
89positive regulation of chemokine secretion (GO:0090197)2.41229805
90leukotriene metabolic process (GO:0006691)2.41107436
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.40534794
92phosphatidylcholine acyl-chain remodeling (GO:0036151)2.40088399
93regulation of cellular extravasation (GO:0002691)2.39499928
94positive regulation of antigen processing and presentation (GO:0002579)2.39406127
95response to host immune response (GO:0052572)2.38906056
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.38906056
97negative regulation of epidermal cell differentiation (GO:0045605)2.38674615
98negative regulation of cell killing (GO:0031342)2.38601173
99negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.38601173
100amine catabolic process (GO:0009310)2.38485243

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.40057628
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.54879037
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.23563176
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.10159705
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.93599683
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.91773549
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.68484827
8VDR_22108803_ChIP-Seq_LS180_Human2.54577274
9FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16632975
10CDX2_20551321_ChIP-Seq_CACO-2_Human1.87978428
11SCL_19346495_ChIP-Seq_HPC-7_Human1.82651307
12RUNX_20019798_ChIP-Seq_JUKART_Human1.79585868
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.68590649
14IRF8_27001747_Chip-Seq_BMDM_Mouse1.68173963
15DROSHA_22980978_ChIP-Seq_HELA_Human1.62586578
16BCAT_22108803_ChIP-Seq_LS180_Human1.58116524
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51899437
18GATA4_25053715_ChIP-Seq_YYC3_Human1.50991250
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.43798356
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42444746
21E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.40138967
22PRDM14_20953172_ChIP-Seq_ESCs_Human1.38487440
23STAT1_20625510_ChIP-Seq_HELA_Human1.36645048
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33713169
25IKZF1_21737484_ChIP-ChIP_HCT116_Human1.32476516
26NANOG_20526341_ChIP-Seq_ESCs_Human1.30801940
27SPI1_23127762_ChIP-Seq_K562_Human1.29555480
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.28496264
29ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26925845
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26863717
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.26821619
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.24087514
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22182596
34RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21788342
35SOX2_20726797_ChIP-Seq_SW620_Human1.20720214
36LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20494753
37GATA3_21878914_ChIP-Seq_MCF-7_Human1.20046715
38VDR_24787735_ChIP-Seq_THP-1_Human1.19895787
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19843648
40PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.19839018
41AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18330332
42RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17212855
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16362372
44FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15271346
45LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15077047
46CEBPB_22108803_ChIP-Seq_LS180_Human1.13076661
47SOX2_27498859_Chip-Seq_STOMACH_Mouse1.12582338
48KAP1_22055183_ChIP-Seq_ESCs_Mouse1.12397893
49GATA3_26560356_Chip-Seq_TH2_Human1.12010860
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11941252
51GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.11355317
52MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11144893
53FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08728931
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08651324
55VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.08143008
56CDX2_22108803_ChIP-Seq_LS180_Human1.07737519
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.05559506
58P300_27268052_Chip-Seq_Bcells_Human1.05047269
59TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04169001
60POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04169001
61STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03863539
62PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.02032906
63MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.01395601
64TAF2_19829295_ChIP-Seq_ESCs_Human1.00020529
65AHR_22903824_ChIP-Seq_MCF-7_Human0.99748147
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99552238
67BCL6_27268052_Chip-Seq_Bcells_Human0.99544956
68* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96587889
69* TCF4_22108803_ChIP-Seq_LS180_Human0.96150594
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95851154
71BMI1_23680149_ChIP-Seq_NPCS_Mouse0.95508879
72GATA3_27048872_Chip-Seq_THYMUS_Human0.92723807
73ARNT_22903824_ChIP-Seq_MCF-7_Human0.91953460
74GATA2_21666600_ChIP-Seq_HMVEC_Human0.91402945
75SMRT_27268052_Chip-Seq_Bcells_Human0.90928229
76MYC_19829295_ChIP-Seq_ESCs_Human0.90432126
77CTBP1_25329375_ChIP-Seq_LNCAP_Human0.90397268
78RXR_22108803_ChIP-Seq_LS180_Human0.90289846
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90269345
80NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89665318
81GATA1_22025678_ChIP-Seq_K562_Human0.89422691
82* SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88313446
83FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87754653
84FOXA1_25329375_ChIP-Seq_VCAP_Human0.87754653
85VDR_24763502_ChIP-Seq_THP-1_Human0.87068139
86MYB_26560356_Chip-Seq_TH2_Human0.86386026
87AR_25329375_ChIP-Seq_VCAP_Human0.86176459
88EZH2_22144423_ChIP-Seq_EOC_Human0.85723206
89AR_20517297_ChIP-Seq_VCAP_Human0.85665591
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.85548644
91ER_23166858_ChIP-Seq_MCF-7_Human0.85347575
92SPI1_23547873_ChIP-Seq_NB4_Human0.85118100
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.84787498
94GATA1_19941826_ChIP-Seq_K562_Human0.83793399
95E2F1_20622854_ChIP-Seq_HELA_Human0.83448973
96GATA6_25053715_ChIP-Seq_YYC3_Human0.83413725
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.83393827
98GATA1_19941827_ChIP-Seq_MEL_Mouse0.83380221
99BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.82983125
100KLF5_25053715_ChIP-Seq_YYC3_Human0.82362739

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot3.57453834
2MP0003878_abnormal_ear_physiology3.57453834
3MP0004147_increased_porphyrin_level3.39580774
4MP0005085_abnormal_gallbladder_physiolo3.20398674
5MP0003806_abnormal_nucleotide_metabolis2.67105783
6MP0003724_increased_susceptibility_to2.66721004
7MP0005360_urolithiasis2.61179812
8MP0001835_abnormal_antigen_presentation2.36363724
9MP0004019_abnormal_vitamin_homeostasis2.32772549
10MP0001666_abnormal_nutrient_absorption2.30542079
11MP0001664_abnormal_digestion2.29446237
12MP0003879_abnormal_hair_cell2.26346438
13MP0010155_abnormal_intestine_physiology2.14146140
14MP0005451_abnormal_body_composition2.08276266
15MP0010329_abnormal_lipoprotein_level2.02839943
16MP0003183_abnormal_peptide_metabolism1.92170546
17MP0005671_abnormal_response_to1.87366569
18MP0001986_abnormal_taste_sensitivity1.84795656
19MP0003866_abnormal_defecation1.84145708
20MP0002138_abnormal_hepatobiliary_system1.79435151
21MP0001800_abnormal_humoral_immune1.78991132
22MP0005365_abnormal_bile_salt1.73303658
23MP0008004_abnormal_stomach_pH1.72873618
24MP0005387_immune_system_phenotype1.72677744
25MP0001790_abnormal_immune_system1.72677744
26MP0001663_abnormal_digestive_system1.72554525
27MP0009785_altered_susceptibility_to1.62913046
28MP0005332_abnormal_amino_acid1.62530833
29MP0001485_abnormal_pinna_reflex1.60375906
30MP0005025_abnormal_response_to1.58525740
31MP0005464_abnormal_platelet_physiology1.57710651
32MP0002132_abnormal_respiratory_system1.55806313
33MP0000685_abnormal_immune_system1.55576690
34MP0003195_calcinosis1.52760726
35MP0003303_peritoneal_inflammation1.51717397
36MP0002139_abnormal_hepatobiliary_system1.49406627
37MP0002419_abnormal_innate_immunity1.45582481
38MP0000372_irregular_coat_pigmentation1.44739518
39MP0005381_digestive/alimentary_phenotyp1.43955503
40MP0002723_abnormal_immune_serum1.42538538
41MP0002452_abnormal_antigen_presenting1.41254912
42MP0003252_abnormal_bile_duct1.38459805
43MP0004883_abnormal_blood_vessel1.38159116
44MP0005310_abnormal_salivary_gland1.34505074
45MP0002396_abnormal_hematopoietic_system1.34030809
46MP0002420_abnormal_adaptive_immunity1.32791649
47MP0009379_abnormal_foot_pigmentation1.32338489
48MP0005058_abnormal_lysosome_morphology1.31427421
49MP0001819_abnormal_immune_cell1.30402560
50MP0005448_abnormal_energy_balance1.29888075
51MP0001765_abnormal_ion_homeostasis1.29026148
52MP0005410_abnormal_fertilization1.27273031
53MP0001845_abnormal_inflammatory_respons1.25103615
54MP0005000_abnormal_immune_tolerance1.25051761
55MP0003638_abnormal_response/metabolism_1.23834240
56MP0001879_abnormal_lymphatic_vessel1.21697969
57MP0001661_extended_life_span1.21556756
58MP0000490_abnormal_crypts_of1.20358894
59MP0005220_abnormal_exocrine_pancreas1.20129362
60MP0001756_abnormal_urination1.19741309
61MP0009643_abnormal_urine_homeostasis1.19685252
62MP0008872_abnormal_physiological_respon1.16330724
63MP0000465_gastrointestinal_hemorrhage1.16275410
64MP0008469_abnormal_protein_level1.15226301
65MP0000230_abnormal_systemic_arterial1.12627534
66MP0005535_abnormal_body_temperature1.11095434
67MP0005084_abnormal_gallbladder_morpholo1.08970173
68MP0001873_stomach_inflammation1.08890616
69MP0000343_altered_response_to1.08759566
70MP0001764_abnormal_homeostasis1.08550549
71MP0005164_abnormal_response_to1.08467672
72MP0002971_abnormal_brown_adipose1.06752458
73MP0002405_respiratory_system_inflammati1.04004275
74MP0005551_abnormal_eye_electrophysiolog1.03935785
75MP0002148_abnormal_hypersensitivity_rea1.02184074
76MP0005584_abnormal_enzyme/coenzyme_acti1.01623291
77MP0005266_abnormal_metabolism1.01485327
78MP0005636_abnormal_mineral_homeostasis1.01399448
79MP0009764_decreased_sensitivity_to1.01318122
80MP0005166_decreased_susceptibility_to0.98549300
81MP0000470_abnormal_stomach_morphology0.98016443
82MP0005376_homeostasis/metabolism_phenot0.96728606
83MP0004742_abnormal_vestibular_system0.96538192
84MP0000716_abnormal_immune_system0.96290953
85MP0000249_abnormal_blood_vessel0.95683704
86MP0010234_abnormal_vibrissa_follicle0.95558038
87MP0002693_abnormal_pancreas_physiology0.95018569
88MP0000569_abnormal_digit_pigmentation0.92388354
89MP0003436_decreased_susceptibility_to0.91595401
90MP0002118_abnormal_lipid_homeostasis0.89173790
91MP0005187_abnormal_penis_morphology0.88414372
92MP0001486_abnormal_startle_reflex0.87200064
93MP0002398_abnormal_bone_marrow0.84703520
94MP0002136_abnormal_kidney_physiology0.83272317
95MP0006082_CNS_inflammation0.80690532
96MP0000477_abnormal_intestine_morphology0.79060209
97MP0002166_altered_tumor_susceptibility0.78457575
98MP0002272_abnormal_nervous_system0.77013246
99MP0003011_delayed_dark_adaptation0.76902678
100MP0003959_abnormal_lean_body0.75148135

Predicted human phenotypes

RankGene SetZ-score
1Azoospermia (HP:0000027)3.83336892
2Bilateral sensorineural hearing impairment (HP:0008619)3.73223816
3Eczematoid dermatitis (HP:0000976)3.61484568
4Systemic lupus erythematosus (HP:0002725)3.58380617
5Congenital, generalized hypertrichosis (HP:0004540)3.37405077
6Abnormal spermatogenesis (HP:0008669)3.27317639
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.19596303
8Abnormality of glutamine family amino acid metabolism (HP:0010902)3.07801615
9Agammaglobulinemia (HP:0004432)3.03177110
10Abnormality of macrophages (HP:0004311)2.99999295
11Glomerulonephritis (HP:0000099)2.94416717
12Hyperlipoproteinemia (HP:0010980)2.90171502
13Polyphagia (HP:0002591)2.82488260
14Congenital sensorineural hearing impairment (HP:0008527)2.79582959
15Congenital stationary night blindness (HP:0007642)2.78606924
16Malnutrition (HP:0004395)2.76835012
17Recurrent fungal infections (HP:0002841)2.75048275
18Gingivitis (HP:0000230)2.74426705
19Severe visual impairment (HP:0001141)2.74080455
20Decreased circulating renin level (HP:0003351)2.61260400
21Hyperactive renin-angiotensin system (HP:0000841)2.58423944
22Chronic diarrhea (HP:0002028)2.58301943
23Recurrent cutaneous fungal infections (HP:0011370)2.49673665
24Chronic mucocutaneous candidiasis (HP:0002728)2.49673665
25Recurrent abscess formation (HP:0002722)2.47203696
263-Methylglutaconic aciduria (HP:0003535)2.43583875
27Meningitis (HP:0001287)2.43580205
28Prolonged bleeding time (HP:0003010)2.42153097
29Gastrointestinal infarctions (HP:0005244)2.41691178
30Recurrent bacterial skin infections (HP:0005406)2.36078336
31Colitis (HP:0002583)2.34830586
32Increased IgE level (HP:0003212)2.30445341
33Pigmentary retinal degeneration (HP:0001146)2.30023966
34Inflammation of the large intestine (HP:0002037)2.28530561
35Abnormality of dental color (HP:0011073)2.24814195
36Complement deficiency (HP:0004431)2.22018361
37Abnormality of renal excretion (HP:0011036)2.21726448
38Hydroxyprolinuria (HP:0003080)2.21284790
39Abnormality of proline metabolism (HP:0010907)2.21284790
40Abnormality of renin-angiotensin system (HP:0000847)2.19675094
41Abnormality of B cell number (HP:0010975)2.18512796
42Nephritis (HP:0000123)2.17885518
43Nasal polyposis (HP:0100582)2.16744743
44Hyperventilation (HP:0002883)2.16407982
45Autoimmune thrombocytopenia (HP:0001973)2.15620195
46Retinal atrophy (HP:0001105)2.14822338
47Pustule (HP:0200039)2.14165446
48Recurrent gram-negative bacterial infections (HP:0005420)2.13735021
49Abolished electroretinogram (ERG) (HP:0000550)2.13682926
50Osteomyelitis (HP:0002754)2.13657899
51Cellulitis (HP:0100658)2.13415033
52Stomach cancer (HP:0012126)2.10970098
53Vascular calcification (HP:0004934)2.08905885
54Cheilitis (HP:0100825)2.06768005
55Delayed CNS myelination (HP:0002188)2.06494469
56Abnormality of the nasal mucosa (HP:0000433)2.06048487
57Abnormality of small intestinal villus morphology (HP:0011472)2.05878957
58Villous atrophy (HP:0011473)2.05878957
59Large for gestational age (HP:0001520)2.05653381
60Chronic sinusitis (HP:0011109)2.05593958
6111 pairs of ribs (HP:0000878)2.05228908
62Recurrent skin infections (HP:0001581)2.02563707
63Gastrointestinal inflammation (HP:0004386)2.01358940
64Exocrine pancreatic insufficiency (HP:0001738)2.01276245
65Fair hair (HP:0002286)1.97067020
66Glycosuria (HP:0003076)1.93955208
67Abnormality of urine glucose concentration (HP:0011016)1.93955208
68Alkalosis (HP:0001948)1.92507811
69Radial bowing (HP:0002986)1.92248203
70Focal segmental glomerulosclerosis (HP:0000097)1.92097144
71Abnormality of renal resorption (HP:0011038)1.91817362
72Recurrent pneumonia (HP:0006532)1.90966541
73Chronic obstructive pulmonary disease (HP:0006510)1.87272679
74Obstructive lung disease (HP:0006536)1.87272679
75Widely patent fontanelles and sutures (HP:0004492)1.87075421
76Short nail (HP:0001799)1.87069068
77Amelogenesis imperfecta (HP:0000705)1.86550544
78Panhypogammaglobulinemia (HP:0003139)1.85270877
79Chronic hepatic failure (HP:0100626)1.85002519
80Generalized hypopigmentation of hair (HP:0011358)1.84336868
81Recurrent viral infections (HP:0004429)1.84330618
82Abnormality of transition element cation homeostasis (HP:0011030)1.83654482
83Encephalitis (HP:0002383)1.82112523
84Metabolic alkalosis (HP:0200114)1.81850464
85Impulsivity (HP:0100710)1.81655994
86Abnormality of complement system (HP:0005339)1.81353769
87Axonal loss (HP:0003447)1.81067411
88Abnormal eating behavior (HP:0100738)1.80736013
89Fat malabsorption (HP:0002630)1.79958631
90Abnormality of chloride homeostasis (HP:0011422)1.79884160
91Decreased central vision (HP:0007663)1.79293278
92Absent/shortened dynein arms (HP:0200106)1.79145071
93Dynein arm defect of respiratory motile cilia (HP:0012255)1.79145071
94Vacuolated lymphocytes (HP:0001922)1.78717137
95Abnormality of T cell physiology (HP:0011840)1.78296910
96Skin rash (HP:0000988)1.77527988
97Glomerulosclerosis (HP:0000096)1.77347604
98Hypothermia (HP:0002045)1.76694880
99Hyperkalemia (HP:0002153)1.76318673
100Abnormality of iron homeostasis (HP:0011031)1.76288686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.59708966
2RIPK43.52031874
3ACVR1B3.37548021
4MAP3K103.05006473
5TNK22.62019449
6CSF1R2.52687986
7MAP4K12.52461626
8NTRK32.38538997
9BMPR22.20142426
10TXK2.17199044
11BMPR1B2.10654422
12FRK2.08331726
13MAPK151.91349939
14SYK1.84709176
15ERN11.82116236
16TYK21.81993118
17MAP3K21.80912153
18PRKG21.79069405
19TAOK11.68416607
20GRK11.64563307
21AKT31.62901234
22LYN1.59553190
23MST1R1.59288524
24ADRBK21.54904956
25KIT1.53963128
26CSK1.53515183
27ZAP701.53496299
28FES1.48203280
29CDK81.40074127
30NEK11.38979127
31STK391.35210092
32TEC1.35163967
33ZAK1.33836147
34MAP3K121.29496311
35TIE11.23726346
36BTK1.21424850
37ITK1.18900590
38MAP2K61.10368440
39IRAK41.07365780
40INSRR1.05808128
41JAK31.05516725
42OXSR11.03827682
43NLK0.99922229
44PIK3CA0.97338759
45PNCK0.96732367
46GRK60.96391906
47CAMK1G0.93191569
48PDK10.90876970
49IKBKE0.90602499
50MAP3K140.90292792
51MET0.88529447
52PIM10.85876823
53HCK0.84836989
54CAMK1D0.81097128
55WNK40.79372874
56MAPKAPK30.78448647
57KSR20.78307399
58RET0.73500250
59JAK10.72418878
60PASK0.72382529
61LCK0.71905928
62IGF1R0.71094635
63JAK20.70986164
64PRKCQ0.70446916
65FGR0.66395959
66PRKG10.64536015
67PIK3CG0.62958466
68CDK30.60152540
69MARK20.59850141
70PDPK10.59301700
71ADRBK10.56488877
72MAP3K40.56410755
73MAPK130.52691936
74PRKAA20.52347757
75MAPK120.51362275
76EGFR0.49498740
77IKBKB0.49135471
78MAPKAPK50.48869280
79TBK10.47892915
80MAP3K10.47717335
81FYN0.47291437
82CAMKK20.46307909
83PRKCZ0.45942053
84WNK10.45780274
85FGFR30.45387422
86MYLK0.45100864
87NEK90.44772069
88PINK10.43929835
89DYRK1B0.43408472
90LMTK20.41537779
91GRK70.41175198
92MAP3K70.41024577
93PRKCE0.39671385
94MAPK70.39060380
95YES10.38819428
96PRKCD0.38486413
97PTK2B0.37953971
98TESK10.37302251
99TAOK30.37219739
100BMX0.36781202

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.77340380
2Staphylococcus aureus infection_Homo sapiens_hsa051502.67486423
3Fat digestion and absorption_Homo sapiens_hsa049752.60147547
4Linoleic acid metabolism_Homo sapiens_hsa005912.41363959
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.28878032
6Nitrogen metabolism_Homo sapiens_hsa009102.25258444
7Vitamin digestion and absorption_Homo sapiens_hsa049772.22293254
8Allograft rejection_Homo sapiens_hsa053302.21179065
9Asthma_Homo sapiens_hsa053102.16705978
10Autoimmune thyroid disease_Homo sapiens_hsa053202.13366965
11Graft-versus-host disease_Homo sapiens_hsa053322.06399414
12Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.06252767
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.03028828
14Type I diabetes mellitus_Homo sapiens_hsa049401.84978305
15Carbohydrate digestion and absorption_Homo sapiens_hsa049731.83693155
16Mineral absorption_Homo sapiens_hsa049781.78204821
17Arachidonic acid metabolism_Homo sapiens_hsa005901.70524764
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69842532
19Leishmaniasis_Homo sapiens_hsa051401.58955284
20Glycerolipid metabolism_Homo sapiens_hsa005611.58217627
21Histidine metabolism_Homo sapiens_hsa003401.56604571
22Ether lipid metabolism_Homo sapiens_hsa005651.54543066
23Renin-angiotensin system_Homo sapiens_hsa046141.46325488
24Caffeine metabolism_Homo sapiens_hsa002321.43187575
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.42347941
26Antigen processing and presentation_Homo sapiens_hsa046121.40111966
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36502016
28Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.35334150
29Primary immunodeficiency_Homo sapiens_hsa053401.33983614
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.29172750
31Chemical carcinogenesis_Homo sapiens_hsa052041.28960618
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26427732
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24899537
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.23722175
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.23427801
36Pancreatic secretion_Homo sapiens_hsa049721.23001910
37ABC transporters_Homo sapiens_hsa020101.21043620
38Bile secretion_Homo sapiens_hsa049761.20666550
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.08312059
40Hematopoietic cell lineage_Homo sapiens_hsa046401.05449961
41B cell receptor signaling pathway_Homo sapiens_hsa046621.05244833
42Protein digestion and absorption_Homo sapiens_hsa049741.00353085
43Tuberculosis_Homo sapiens_hsa051520.95854358
44Osteoclast differentiation_Homo sapiens_hsa043800.94833213
45Sulfur metabolism_Homo sapiens_hsa009200.94770065
46Serotonergic synapse_Homo sapiens_hsa047260.94218105
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89872076
48Oxidative phosphorylation_Homo sapiens_hsa001900.86889666
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.86878700
50Retinol metabolism_Homo sapiens_hsa008300.85217693
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84746617
52Gastric acid secretion_Homo sapiens_hsa049710.82922765
53Platelet activation_Homo sapiens_hsa046110.82064900
54PPAR signaling pathway_Homo sapiens_hsa033200.81796322
55Starch and sucrose metabolism_Homo sapiens_hsa005000.80731745
56Influenza A_Homo sapiens_hsa051640.80216355
57Fatty acid degradation_Homo sapiens_hsa000710.78841871
58Chemokine signaling pathway_Homo sapiens_hsa040620.78017557
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.76567681
60Toxoplasmosis_Homo sapiens_hsa051450.73105585
61Tryptophan metabolism_Homo sapiens_hsa003800.72358902
62Collecting duct acid secretion_Homo sapiens_hsa049660.68927306
63Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.68859197
64Rheumatoid arthritis_Homo sapiens_hsa053230.68725055
65Butanoate metabolism_Homo sapiens_hsa006500.65859365
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60488956
67Pertussis_Homo sapiens_hsa051330.60444912
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.60403847
69Long-term depression_Homo sapiens_hsa047300.60352209
70Arginine biosynthesis_Homo sapiens_hsa002200.59195641
71Phagosome_Homo sapiens_hsa041450.59094324
72Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57625978
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57596993
74Folate biosynthesis_Homo sapiens_hsa007900.56928047
75Peroxisome_Homo sapiens_hsa041460.55770547
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53951857
77Taste transduction_Homo sapiens_hsa047420.53783138
78Glycerophospholipid metabolism_Homo sapiens_hsa005640.53132123
79Viral myocarditis_Homo sapiens_hsa054160.52976512
80African trypanosomiasis_Homo sapiens_hsa051430.50564342
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.50108226
82Thyroid hormone synthesis_Homo sapiens_hsa049180.49786300
83Ovarian steroidogenesis_Homo sapiens_hsa049130.49700800
84Complement and coagulation cascades_Homo sapiens_hsa046100.48292056
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.48290621
86NF-kappa B signaling pathway_Homo sapiens_hsa040640.47394198
87Salivary secretion_Homo sapiens_hsa049700.47392203
88Sphingolipid metabolism_Homo sapiens_hsa006000.46208826
89Parkinsons disease_Homo sapiens_hsa050120.46180696
90Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.44863005
91Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43863202
92Galactose metabolism_Homo sapiens_hsa000520.42822296
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42750756
94Phenylalanine metabolism_Homo sapiens_hsa003600.40276661
95Cholinergic synapse_Homo sapiens_hsa047250.40185543
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39785346
97Renin secretion_Homo sapiens_hsa049240.39176748
98Glutamatergic synapse_Homo sapiens_hsa047240.37501982
99Fatty acid biosynthesis_Homo sapiens_hsa000610.35203945
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.34794035

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