FAM178B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.92409012
2acrosome reaction (GO:0007340)9.56395685
3sperm-egg recognition (GO:0035036)9.52118406
4axonemal dynein complex assembly (GO:0070286)9.28963732
5binding of sperm to zona pellucida (GO:0007339)9.01880646
6acrosome assembly (GO:0001675)8.90877301
7spermatid development (GO:0007286)8.56695407
8cell-cell recognition (GO:0009988)8.48543217
9multicellular organism reproduction (GO:0032504)8.47897311
10motile cilium assembly (GO:0044458)8.36228335
11male meiosis (GO:0007140)8.32626660
12cell wall macromolecule metabolic process (GO:0044036)8.31930559
13cell wall macromolecule catabolic process (GO:0016998)8.31930559
14epithelial cilium movement (GO:0003351)8.27041446
15synaptonemal complex organization (GO:0070193)8.19579117
16synaptonemal complex assembly (GO:0007130)8.04035717
17plasma membrane fusion (GO:0045026)7.89082483
18regulation of cilium movement (GO:0003352)7.65646398
19reproduction (GO:0000003)7.12043297
20cilium movement (GO:0003341)7.00129766
21epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.98883467
22DNA methylation involved in gamete generation (GO:0043046)6.92423428
23protoporphyrinogen IX metabolic process (GO:0046501)6.80479824
24negative regulation of inclusion body assembly (GO:0090084)6.10847652
25male meiosis I (GO:0007141)6.08463763
26protoporphyrinogen IX biosynthetic process (GO:0006782)6.06806951
27single fertilization (GO:0007338)6.00187890
28spermatogenesis (GO:0007283)5.92187827
29male gamete generation (GO:0048232)5.90610100
30chromosome organization involved in meiosis (GO:0070192)5.77165220
31microtubule depolymerization (GO:0007019)5.61416185
32fertilization (GO:0009566)5.60936534
33sperm capacitation (GO:0048240)5.49397761
34meiotic nuclear division (GO:0007126)5.48992140
35gamete generation (GO:0007276)5.46400889
36germ cell development (GO:0007281)5.27076005
37erythrocyte maturation (GO:0043249)5.18403066
38DNA replication checkpoint (GO:0000076)5.14238611
39oxygen transport (GO:0015671)5.10919488
40DNA topological change (GO:0006265)5.06343841
41meiosis I (GO:0007127)5.06340722
42regulation of inclusion body assembly (GO:0090083)5.04210184
43gas transport (GO:0015669)5.02564779
44cellular process involved in reproduction in multicellular organism (GO:0022412)4.96149175
45regulation of translational fidelity (GO:0006450)4.85485215
46seminiferous tubule development (GO:0072520)4.73781802
47regulation of microtubule-based movement (GO:0060632)4.72069089
48organic cation transport (GO:0015695)4.71901475
49meiotic cell cycle (GO:0051321)4.66159022
50regulation of histone H3-K4 methylation (GO:0051569)4.56675308
51microtubule severing (GO:0051013)4.54663965
52negative regulation of erythrocyte differentiation (GO:0045647)4.52339732
53DNA packaging (GO:0006323)4.47305577
54chromosome condensation (GO:0030261)4.47018598
55ventricular system development (GO:0021591)4.46553848
56DNA replication initiation (GO:0006270)4.44806319
57DNA unwinding involved in DNA replication (GO:0006268)4.41137587
58proline biosynthetic process (GO:0006561)4.39351705
59porphyrin-containing compound biosynthetic process (GO:0006779)4.35217323
60heme biosynthetic process (GO:0006783)4.29219773
61multicellular organismal reproductive process (GO:0048609)4.25636952
62regulation of meiosis I (GO:0060631)4.13881575
63granulocyte differentiation (GO:0030851)4.10227861
64erythrocyte development (GO:0048821)4.06954474
65oxidative phosphorylation (GO:0006119)4.06921011
66gene silencing by RNA (GO:0031047)4.05120700
67chaperone-mediated protein complex assembly (GO:0051131)3.99964196
68formation of translation preinitiation complex (GO:0001731)3.97806203
69potassium ion export (GO:0071435)3.97704940
70diterpenoid biosynthetic process (GO:0016102)3.93362649
71calcium ion-dependent exocytosis (GO:0017156)3.92822608
72cell recognition (GO:0008037)3.92249056
73DNA strand elongation involved in DNA replication (GO:0006271)3.92154547
74mitotic nuclear envelope disassembly (GO:0007077)3.91776706
75meiotic cell cycle process (GO:1903046)3.91164605
76tetrapyrrole biosynthetic process (GO:0033014)3.90205403
77nuclear pore complex assembly (GO:0051292)3.88244872
78mitotic sister chromatid segregation (GO:0000070)3.87190835
79folic acid-containing compound biosynthetic process (GO:0009396)3.84906967
80porphyrin-containing compound metabolic process (GO:0006778)3.84106526
81DNA strand elongation (GO:0022616)3.79290463
82regulation of spindle checkpoint (GO:0090231)3.79176212
83protein polyglutamylation (GO:0018095)3.78855323
84left/right pattern formation (GO:0060972)3.78767294
85membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.75420100
86purine nucleobase biosynthetic process (GO:0009113)3.71715589
87regulation of histone H3-K27 methylation (GO:0061085)3.69819541
88terpenoid biosynthetic process (GO:0016114)3.68429729
89heme metabolic process (GO:0042168)3.66394690
90meiotic chromosome segregation (GO:0045132)3.65534875
91sister chromatid segregation (GO:0000819)3.61919476
92synapsis (GO:0007129)3.61080834
93phosphorelay signal transduction system (GO:0000160)3.59097600
94membrane disassembly (GO:0030397)3.58210850
95nuclear envelope disassembly (GO:0051081)3.58210850
96single strand break repair (GO:0000012)3.58184111
97nucleobase biosynthetic process (GO:0046112)3.54265820
98creatine metabolic process (GO:0006600)3.53817786
99tRNA aminoacylation for protein translation (GO:0006418)3.51416124
100definitive hemopoiesis (GO:0060216)3.50476991
101oxaloacetate metabolic process (GO:0006107)3.47411138
102telomere maintenance via semi-conservative replication (GO:0032201)3.46486726
103DNA replication-dependent nucleosome organization (GO:0034723)3.45673528
104DNA replication-dependent nucleosome assembly (GO:0006335)3.45673528
105homocysteine metabolic process (GO:0050667)3.45423639
106negative regulation of potassium ion transmembrane transport (GO:1901380)3.44605882
107viral mRNA export from host cell nucleus (GO:0046784)3.42855734
108nuclear pore organization (GO:0006999)3.42457242
109tetrahydrofolate metabolic process (GO:0046653)3.41552209
110protein localization to cilium (GO:0061512)3.41482010
111IMP biosynthetic process (GO:0006188)3.38657538
112tRNA aminoacylation (GO:0043039)3.37999807
113amino acid activation (GO:0043038)3.37999807
114multicellular organismal development (GO:0007275)3.37689640
115genitalia morphogenesis (GO:0035112)3.34212761
116regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.34132778
117microtubule polymerization or depolymerization (GO:0031109)3.33130934
118glycerol ether metabolic process (GO:0006662)3.32322969
119resolution of meiotic recombination intermediates (GO:0000712)3.31543347
120monoubiquitinated protein deubiquitination (GO:0035520)3.30453884
121membrane repolarization during action potential (GO:0086011)3.28451012
122succinate metabolic process (GO:0006105)3.24862806
123ribosomal small subunit assembly (GO:0000028)3.24767795
124positive regulation of megakaryocyte differentiation (GO:0045654)3.23366841
125regulation of RNA export from nucleus (GO:0046831)3.22584272
126nucleus organization (GO:0006997)3.21986582
127mitotic sister chromatid cohesion (GO:0007064)3.21203694
128negative regulation of organelle assembly (GO:1902116)3.21050100
129heterochromatin organization (GO:0070828)3.20802148
130gene silencing (GO:0016458)3.20799122
131intra-S DNA damage checkpoint (GO:0031573)3.19114066
132pore complex assembly (GO:0046931)3.18060904
133spermatid nucleus differentiation (GO:0007289)3.17741535
134protein refolding (GO:0042026)3.16423385
135ribosome biogenesis (GO:0042254)3.15360805
136vitamin A metabolic process (GO:0006776)3.13644306
137regulation of histone H3-K9 methylation (GO:0051570)3.12879732
138DNA alkylation (GO:0006305)3.10714557
139DNA methylation (GO:0006306)3.10714557
140mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.09976316
141regulation of histone methylation (GO:0031060)3.09833371
142valine metabolic process (GO:0006573)3.09677939
143positive regulation of histone H3-K4 methylation (GO:0051571)3.08804107
144intraciliary transport (GO:0042073)3.06878182
145ether metabolic process (GO:0018904)3.05267559
146protein localization to chromosome, centromeric region (GO:0071459)2.99808070
147regulation of translational elongation (GO:0006448)2.99513067
148pigment biosynthetic process (GO:0046148)2.98914346
149telomere maintenance via recombination (GO:0000722)2.98348733
150regulation of centriole replication (GO:0046599)2.98145742
151chromosome segregation (GO:0007059)2.96689442
152histone exchange (GO:0043486)2.95195058
153mitotic recombination (GO:0006312)2.93760984
154protein complex localization (GO:0031503)2.93584723
155ATP biosynthetic process (GO:0006754)2.92261045
156negative regulation of histone methylation (GO:0031061)2.91273175
157aerobic respiration (GO:0009060)2.88956261
158proteasome assembly (GO:0043248)2.88869878
159purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.88622550
160purine nucleoside monophosphate biosynthetic process (GO:0009127)2.88622550
161IMP metabolic process (GO:0046040)2.87799671
162axoneme assembly (GO:0035082)2.86159549
163ribonucleoprotein complex biogenesis (GO:0022613)2.85226611
164ribosomal large subunit biogenesis (GO:0042273)2.82966123
165positive regulation of histone methylation (GO:0031062)2.81386688
166cellular response to thyroid hormone stimulus (GO:0097067)2.79400305
167response to thyroid hormone (GO:0097066)2.78301710
168Peyers patch development (GO:0048541)2.78153887
169mucosal-associated lymphoid tissue development (GO:0048537)2.78153887
170interferon-gamma secretion (GO:0072643)2.78056428
171proline metabolic process (GO:0006560)2.77425550
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75786096
173ATP synthesis coupled proton transport (GO:0015986)2.75786096
174mitotic chromosome condensation (GO:0007076)2.74958555
175pseudouridine synthesis (GO:0001522)2.74790799
176microtubule-based movement (GO:0007018)2.74142269
177sex differentiation (GO:0007548)2.72240382
178sister chromatid cohesion (GO:0007062)2.70679601
179regulation of erythrocyte differentiation (GO:0045646)2.70325873
180regulation of mitotic spindle organization (GO:0060236)2.70183851
181centriole assembly (GO:0098534)2.69432201
182DNA damage induced protein phosphorylation (GO:0006975)2.68709539
183RNA localization (GO:0006403)2.67684262
184reciprocal meiotic recombination (GO:0007131)2.62960458
185reciprocal DNA recombination (GO:0035825)2.62960458
186carnitine transport (GO:0015879)2.58088461
187amino-acid betaine transport (GO:0015838)2.58088461
188chromosome organization (GO:0051276)2.53516090
189carnitine transmembrane transport (GO:1902603)2.52954939
190centriole replication (GO:0007099)2.52387180
191sperm motility (GO:0030317)10.8584228
192fusion of sperm to egg plasma membrane (GO:0007342)10.5490583
193piRNA metabolic process (GO:0034587)10.2855060

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.72688986
2GATA1_22025678_ChIP-Seq_K562_Human3.32554744
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31137581
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29319977
5EZH2_22144423_ChIP-Seq_EOC_Human3.16074251
6HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.13405141
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.07892272
8GATA1_19941826_ChIP-Seq_K562_Human2.88016103
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76983707
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.75039184
11* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.65369913
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.63060447
13* NCOR1_26117541_ChIP-Seq_K562_Human2.51446013
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51437206
15GATA1_26923725_Chip-Seq_HPCs_Mouse2.49148626
16PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.41528062
17XRN2_22483619_ChIP-Seq_HELA_Human2.40271351
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26727327
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.23971238
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.23879513
21THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22684885
22MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21177668
23STAT6_21828071_ChIP-Seq_BEAS2B_Human2.15005009
24DCP1A_22483619_ChIP-Seq_HELA_Human2.09635542
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.08929793
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.00919040
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00612197
28VDR_22108803_ChIP-Seq_LS180_Human2.00068782
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse11.4283969
30TTF2_22483619_ChIP-Seq_HELA_Human1.94201560
31BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.93910520
32FOXP3_21729870_ChIP-Seq_TREG_Human1.84243572
33E2F7_22180533_ChIP-Seq_HELA_Human1.83125478
34* GATA2_19941826_ChIP-Seq_K562_Human1.79521924
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78406411
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.77068904
37SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76147759
38FOXM1_23109430_ChIP-Seq_U2OS_Human1.75597643
39GABP_19822575_ChIP-Seq_HepG2_Human1.75271528
40KDM5A_27292631_Chip-Seq_BREAST_Human1.75215882
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73648986
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.72424367
43FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72111498
44VDR_23849224_ChIP-Seq_CD4+_Human1.71628519
45YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71124634
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.70183495
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65266101
48SCL_19346495_ChIP-Seq_HPC-7_Human1.64391871
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64026194
50CIITA_25753668_ChIP-Seq_RAJI_Human1.63351046
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.62191995
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.62107198
53E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60601789
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60247105
55CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.57421999
56SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57002711
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.55395546
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53802763
59PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.51203188
60MYC_22102868_ChIP-Seq_BL_Human1.49096264
61SOX2_22085726_ChIP-Seq_NPCs_Mouse1.48679907
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.48599049
63TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48128477
64KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43616962
65YY1_22570637_ChIP-Seq_MALME-3M_Human1.42389982
66GATA3_21867929_ChIP-Seq_CD8_Mouse1.41615080
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41353121
68FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40217684
69SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.40194816
70SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.36579512
71ELK1_19687146_ChIP-ChIP_HELA_Human1.36489708
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.35889892
73KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.34867116
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34146695
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33803590
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33304142
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32256520
78PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.31868465
79FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.30509934
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30200112
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28467272
82* STAT1_17558387_ChIP-Seq_HELA_Human1.28430501
83CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24440061
84* FLI1_27457419_Chip-Seq_LIVER_Mouse1.24373156
85* SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.22077878
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.20225055
87SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19958900
88WDR5_24793694_ChIP-Seq_LNCAP_Human1.19320808
89FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19265860
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18816614
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18816614
92KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18816614
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18631898
94RXRA_24833708_ChIP-Seq_LIVER_Mouse1.17583407
95MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17492283
96CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16744411
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15780563
98SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13466095
99GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.13117999
100LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.11143800
101SPI1_23127762_ChIP-Seq_K562_Human1.10633073
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.09649676
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09602535
104SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09163864
105RUNX1_26923725_Chip-Seq_HPCs_Mouse1.08299452
106RARA_24833708_ChIP-Seq_LIVER_Mouse1.08237654
107SPI1_26923725_Chip-Seq_HPCs_Mouse1.08069585
108* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07977622
109GATA3_21867929_ChIP-Seq_TH1_Mouse1.07531747
110ZNF274_21170338_ChIP-Seq_K562_Hela1.07342940
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.05948971
112* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05756034
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05223531
114P53_21459846_ChIP-Seq_SAOS-2_Human1.05143266
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.05073355
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04522022
117SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04391049
118CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04198130
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02494550
120ESET_19884257_ChIP-Seq_ESCs_Mouse1.02377976
121E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02069172
122RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01934171
123TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01348961
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00723730
125RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00609042
126CTCF_20526341_ChIP-Seq_ESCs_Human1.00549440
127PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98482090
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.98222428
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.97888269
130POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.97288429
131PHF8_20622854_ChIP-Seq_HELA_Human0.97238467
132TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97184296
133TFEB_21752829_ChIP-Seq_HELA_Human0.96878087
134STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96746515
135ZNF263_19887448_ChIP-Seq_K562_Human0.96589886
136STAT3_18555785_ChIP-Seq_MESCs_Mouse0.95639630
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.95564456
138RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95539501
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95498885
140TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95042716
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94425988
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94073746
143DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94010772
144TAL1_26923725_Chip-Seq_HPCs_Mouse0.93548532
145STAT1_20625510_ChIP-Seq_HELA_Human0.93299980
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93287429
147EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92764824
148MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.92013015
149LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.91720320
150MYC_18358816_ChIP-ChIP_MESCs_Mouse0.91384347
151BCOR_27268052_Chip-Seq_Bcells_Human0.90888155
152ERG_20517297_ChIP-Seq_VCAP_Human0.90066447
153FLI1_21867929_ChIP-Seq_CD8_Mouse0.89697083
154CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88889551
155PCGF2_27294783_Chip-Seq_NPCs_Mouse0.88669339
156MYC_27129775_Chip-Seq_CORNEA_Mouse0.88562420
157YY1_21170310_ChIP-Seq_MESCs_Mouse0.88307231
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88000565
159SOX11_22085726_ChIP-Seq_ESNs_Mouse0.87532111
160CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.85844503
161AR_21909140_ChIP-Seq_LNCAP_Human0.84353257
162FOXP1_21924763_ChIP-Seq_HESCs_Human0.84128706
163GF1_26923725_Chip-Seq_HPCs_Mouse0.83380651
164PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83302954
165RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.82931666
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.82891224
167E2F1_20622854_ChIP-Seq_HELA_Human0.82625486
168CTCF_26484167_Chip-Seq_Bcells_Mouse0.82304402
169VDR_21846776_ChIP-Seq_THP-1_Human0.82219168
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.82197486
171KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82184620
172NANOG_20526341_ChIP-Seq_ESCs_Human0.82164718
173SOX2_21211035_ChIP-Seq_LN229_Human0.81324896
174SRY_22984422_ChIP-ChIP_TESTIS_Rat0.80708357
175MYC_18940864_ChIP-ChIP_HL60_Human0.79729625
176ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76654049
177ESR1_15608294_ChIP-ChIP_MCF-7_Human0.76458085
178SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.75687049
179MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.73715528

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004147_increased_porphyrin_level6.79065142
2MP0008877_abnormal_DNA_methylation5.70182478
3MP0003698_abnormal_male_reproductive5.47279216
4MP0001929_abnormal_gametogenesis5.28199533
5MP0003656_abnormal_erythrocyte_physiolo4.65257905
6MP0002210_abnormal_sex_determination3.87888259
7MP0001145_abnormal_male_reproductive3.29499141
8MP0002653_abnormal_ependyma_morphology3.19933480
9MP0004145_abnormal_muscle_electrophysio3.10076161
10MP0002161_abnormal_fertility/fecundity3.08253508
11MP0000653_abnormal_sex_gland2.85706876
12MP0005171_absent_coat_pigmentation2.69204872
13MP0005083_abnormal_biliary_tract2.58252246
14MP0002132_abnormal_respiratory_system2.44901475
15MP0000372_irregular_coat_pigmentation2.43067153
16MP0000678_abnormal_parathyroid_gland2.42073737
17MP0008057_abnormal_DNA_replication2.40492817
18MP0010094_abnormal_chromosome_stability2.35678856
19MP0005451_abnormal_body_composition2.24605953
20MP0002160_abnormal_reproductive_system2.24241719
21MP0009697_abnormal_copulation2.10822257
22MP0003111_abnormal_nucleus_morphology2.03967338
23MP0008058_abnormal_DNA_repair2.01806998
24MP0005410_abnormal_fertilization13.3487944
25MP0002396_abnormal_hematopoietic_system1.94516271
26MP0003186_abnormal_redox_activity1.88335777
27MP0005670_abnormal_white_adipose1.82050432
28MP0005636_abnormal_mineral_homeostasis1.66377213
29MP0005623_abnormal_meninges_morphology1.57820238
30MP0008995_early_reproductive_senescence1.53031194
31MP0003077_abnormal_cell_cycle1.46949705
32MP0002095_abnormal_skin_pigmentation1.42115536
33MP0003786_premature_aging1.39403735
34MP0004957_abnormal_blastocyst_morpholog1.38997392
35MP0003646_muscle_fatigue1.36912884
36MP0003693_abnormal_embryo_hatching1.35859474
37MP0008775_abnormal_heart_ventricle1.32552718
38MP0004233_abnormal_muscle_weight1.28515250
39MP0005389_reproductive_system_phenotype1.26145665
40MP0004133_heterotaxia1.24883320
41MP0001529_abnormal_vocalization1.21729776
42MP0001730_embryonic_growth_arrest1.20530899
43MP0005408_hypopigmentation1.18913953
44MP0000015_abnormal_ear_pigmentation1.10795597
45MP0008007_abnormal_cellular_replicative1.10185990
46MP0002837_dystrophic_cardiac_calcinosis1.07734624
47MP0001293_anophthalmia1.06770793
48MP0001873_stomach_inflammation1.04294620
49MP0003878_abnormal_ear_physiology1.03030918
50MP0005377_hearing/vestibular/ear_phenot1.03030918
51MP0003806_abnormal_nucleotide_metabolis1.01711668
52MP0002282_abnormal_trachea_morphology1.00802667
53MP0003011_delayed_dark_adaptation1.00533375
54MP0003959_abnormal_lean_body1.00467398
55MP0008932_abnormal_embryonic_tissue0.96437612
56MP0005647_abnormal_sex_gland0.96352215
57MP0005075_abnormal_melanosome_morpholog0.96341333
58MP0003950_abnormal_plasma_membrane0.92137803
59MP0006292_abnormal_olfactory_placode0.88824966
60MP0005646_abnormal_pituitary_gland0.88824500
61MP0008770_decreased_survivor_rate0.87468950
62MP0002938_white_spotting0.87458486
63MP0002722_abnormal_immune_system0.86177155
64MP0000703_abnormal_thymus_morphology0.84844966
65MP0002084_abnormal_developmental_patter0.84508464
66MP0005380_embryogenesis_phenotype0.81068018
67MP0001672_abnormal_embryogenesis/_devel0.81068018
68MP0010307_abnormal_tumor_latency0.80943283
69MP0004808_abnormal_hematopoietic_stem0.78699615
70MP0005645_abnormal_hypothalamus_physiol0.77808928
71MP0000609_abnormal_liver_physiology0.77335927
72MP0002085_abnormal_embryonic_tissue0.75774835
73MP0001881_abnormal_mammary_gland0.75674331
74MP0002398_abnormal_bone_marrow0.74942108
75MP0001697_abnormal_embryo_size0.74269532
76MP0003699_abnormal_female_reproductive0.73340443
77MP0003115_abnormal_respiratory_system0.73278746
78MP0000358_abnormal_cell_content/0.73066905
79MP0008872_abnormal_physiological_respon0.72782919
80MP0009278_abnormal_bone_marrow0.70785722
81MP0009931_abnormal_skin_appearance0.70424047
82MP0003718_maternal_effect0.70181837
83MP0000350_abnormal_cell_proliferation0.69476894
84MP0001119_abnormal_female_reproductive0.69060706
85MP0000689_abnormal_spleen_morphology0.68581585
86MP0001849_ear_inflammation0.67666705
87MP0000313_abnormal_cell_death0.66528543
88MP0003385_abnormal_body_wall0.65589432
89MP0002269_muscular_atrophy0.62494025
90MP0001502_abnormal_circadian_rhythm0.62266741
91MP0003123_paternal_imprinting0.62227238
92MP0000598_abnormal_liver_morphology0.62002465
93MP0003984_embryonic_growth_retardation0.60706785
94MP0002080_prenatal_lethality0.60592792
95MP0003890_abnormal_embryonic-extraembry0.60119798
96MP0000681_abnormal_thyroid_gland0.60097997
97MP0001984_abnormal_olfaction0.59111812
98MP0004197_abnormal_fetal_growth/weight/0.58568292
99MP0003283_abnormal_digestive_organ0.58065814
100MP0002088_abnormal_embryonic_growth/wei0.57497023
101MP0009333_abnormal_splenocyte_physiolog0.56496632
102MP0002429_abnormal_blood_cell0.55083893
103MP0003315_abnormal_perineum_morphology0.54916002
104MP0003861_abnormal_nervous_system0.54106872
105MP0000747_muscle_weakness0.54040565
106MP0000647_abnormal_sebaceous_gland0.52710498
107MP0003936_abnormal_reproductive_system0.52598219
108MP0005332_abnormal_amino_acid0.52454786
109MP0003136_yellow_coat_color0.51661860
110MP0001545_abnormal_hematopoietic_system0.51524402
111MP0005397_hematopoietic_system_phenotyp0.51524402
112MP0005220_abnormal_exocrine_pancreas0.51257231
113MP0005535_abnormal_body_temperature0.49221736
114MP0002092_abnormal_eye_morphology0.46963465
115MP0005391_vision/eye_phenotype0.45753240
116MP0002086_abnormal_extraembryonic_tissu0.45612843
117MP0003119_abnormal_digestive_system0.44033663
118MP0000537_abnormal_urethra_morphology0.39987675
119MP0004264_abnormal_extraembryonic_tissu0.39629445
120MP0010352_gastrointestinal_tract_polyps0.39532993
121MP0001661_extended_life_span0.38489534
122MP0006036_abnormal_mitochondrial_physio0.36894386
123MP0000432_abnormal_head_morphology0.36883601
124MP0005253_abnormal_eye_physiology0.36384224
125MP0005666_abnormal_adipose_tissue0.33903973
126MP0001765_abnormal_ion_homeostasis0.31326340
127MP0009046_muscle_twitch0.31209246
128MP0001324_abnormal_eye_pigmentation0.30994021
129MP0000534_abnormal_ureter_morphology0.30799311
130MP0002796_impaired_skin_barrier0.30096397
131MP0002019_abnormal_tumor_incidence0.29821961
132MP0001764_abnormal_homeostasis0.29564030
133MP0003942_abnormal_urinary_system0.29527443
134MP0005266_abnormal_metabolism0.28541047
135MP0004036_abnormal_muscle_relaxation0.28421479
136MP0003632_abnormal_nervous_system0.28263205
137MP0006072_abnormal_retinal_apoptosis0.28098809
138MP0002697_abnormal_eye_size0.27942377
139MP0005395_other_phenotype0.27351058
140MP0001727_abnormal_embryo_implantation0.26731826
141MP0002152_abnormal_brain_morphology0.25914043
142MP0001348_abnormal_lacrimal_gland0.25496937
143MP0006035_abnormal_mitochondrial_morpho0.25159888
144MP0009703_decreased_birth_body0.24773818
145MP0002169_no_abnormal_phenotype0.24645766
146MP0002873_normal_phenotype0.24351051
147MP0002114_abnormal_axial_skeleton0.24227441

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.48801348
2Abnormal respiratory motile cilium morphology (HP:0005938)8.13541038
3Abnormal respiratory epithelium morphology (HP:0012253)8.13541038
4Reticulocytosis (HP:0001923)7.37958658
5Rhinitis (HP:0012384)7.08476528
6Abnormality of the heme biosynthetic pathway (HP:0010472)6.81026487
7Chronic bronchitis (HP:0004469)6.76540118
8Abnormal ciliary motility (HP:0012262)6.51121136
9Infertility (HP:0000789)6.46052900
10Polycythemia (HP:0001901)5.92702701
11Abnormality of reticulocytes (HP:0004312)5.79617204
12Nasal polyposis (HP:0100582)5.53891282
13Truncus arteriosus (HP:0001660)5.43999641
14Hyperthyroidism (HP:0000836)5.10794984
15Cholelithiasis (HP:0001081)4.69429435
16Abnormality of the nasal mucosa (HP:0000433)4.43561004
17Male infertility (HP:0003251)4.38612361
18Abnormal gallbladder morphology (HP:0012437)4.26270500
19Ileus (HP:0002595)4.22249274
20Bronchiectasis (HP:0002110)4.17776761
21Poikilocytosis (HP:0004447)4.17671219
22Nephronophthisis (HP:0000090)4.11418269
23Acanthocytosis (HP:0001927)4.01707790
24Bronchitis (HP:0012387)3.96260418
25Birth length less than 3rd percentile (HP:0003561)3.96192537
26Hypertensive crisis (HP:0100735)3.84007642
27Abnormal hemoglobin (HP:0011902)3.78255707
28Abnormal number of erythroid precursors (HP:0012131)3.70278100
29Nonimmune hydrops fetalis (HP:0001790)3.69254259
30Impulsivity (HP:0100710)3.66834315
31Abnormal spermatogenesis (HP:0008669)3.64161308
32Abnormality of cells of the erythroid lineage (HP:0012130)3.48420645
33Seborrheic dermatitis (HP:0001051)3.48040937
34Bowel incontinence (HP:0002607)3.41264160
35Pallor (HP:0000980)3.35796946
36Abnormality of the gallbladder (HP:0005264)3.33607529
37Abnormality of the lower motor neuron (HP:0002366)3.27538321
38Abnormal large intestine physiology (HP:0012700)3.26930427
39Abnormality of homocysteine metabolism (HP:0010919)3.25749434
40Homocystinuria (HP:0002156)3.25749434
41Hypoparathyroidism (HP:0000829)3.22515501
42Hyperbilirubinemia (HP:0002904)3.17492486
43Gonadotropin excess (HP:0000837)3.12752926
44Short middle phalanx of the 5th finger (HP:0004220)3.08093202
45Abnormality of the renal medulla (HP:0100957)3.07727704
46Chromsome breakage (HP:0040012)2.98967823
47Abnormality of cochlea (HP:0000375)2.97214527
48Recurrent otitis media (HP:0000403)2.90212050
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.87263933
50Tubulointerstitial nephritis (HP:0001970)2.76247374
51Abnormality of glycolysis (HP:0004366)2.73943708
52Atelectasis (HP:0100750)2.72734079
53Ankyloglossia (HP:0010296)2.68923224
54Azoospermia (HP:0000027)2.68276296
55Impaired proprioception (HP:0010831)2.68034981
56Abnormality of the tricuspid valve (HP:0001702)2.65458461
57Ventricular fibrillation (HP:0001663)2.60274242
58Molar tooth sign on MRI (HP:0002419)2.55377387
59Abnormality of midbrain morphology (HP:0002418)2.55377387
60Increased serum pyruvate (HP:0003542)2.53300864
61Tubular atrophy (HP:0000092)2.51235225
62Morphological abnormality of the inner ear (HP:0011390)2.45844061
63Reticulocytopenia (HP:0001896)2.45340802
64Cortical dysplasia (HP:0002539)2.40085549
65Supernumerary spleens (HP:0009799)2.39999115
66Duplicated collecting system (HP:0000081)2.37315306
67Amyotrophic lateral sclerosis (HP:0007354)2.36949272
68Acute encephalopathy (HP:0006846)2.36632303
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.35958968
70Aplasia/Hypoplasia of the earlobes (HP:0009906)2.34787636
71Recurrent sinusitis (HP:0011108)2.31193249
72Acute myeloid leukemia (HP:0004808)2.26407591
73Tubulointerstitial abnormality (HP:0001969)2.20198052
74Spastic tetraparesis (HP:0001285)2.17746960
75Abnormal mitochondria in muscle tissue (HP:0008316)2.16720999
76Abnormally folded helix (HP:0008544)2.14722250
77Abnormality of the renal collecting system (HP:0004742)2.13299181
78Medial flaring of the eyebrow (HP:0010747)2.10164958
79Recurrent bronchitis (HP:0002837)2.09407284
80Aplasia/Hypoplasia of the thymus (HP:0010515)2.09215402
81Postaxial foot polydactyly (HP:0001830)2.07873263
82Abnormality of the anterior horn cell (HP:0006802)2.07580381
83Degeneration of anterior horn cells (HP:0002398)2.07580381
84Facial cleft (HP:0002006)2.04368006
85Acute necrotizing encephalopathy (HP:0006965)2.03495409
86Myelodysplasia (HP:0002863)2.00811634
87Short ribs (HP:0000773)2.00510667
88Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.3172464
89Dynein arm defect of respiratory motile cilia (HP:0012255)11.5340027
90Absent/shortened dynein arms (HP:0200106)11.5340027
91Heterotopia (HP:0002282)1.96227176
92Tinnitus (HP:0000360)1.92938879
93Macrocytic anemia (HP:0001972)1.91670836
94Palpitations (HP:0001962)1.91558469
95Paralysis (HP:0003470)1.91167425
96Breech presentation (HP:0001623)1.89646060
97Flat cornea (HP:0007720)1.87430748
98Fibular hypoplasia (HP:0003038)1.85971920
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.84421552
100Absent epiphyses (HP:0010577)1.84421552
101Breast hypoplasia (HP:0003187)1.82896947
102Increased serum ferritin (HP:0003281)1.82890415
103Stage 5 chronic kidney disease (HP:0003774)1.82106444
104Orthostatic hypotension (HP:0001278)1.82104196
105Abnormality of sulfur amino acid metabolism (HP:0004339)1.82023972
106Overlapping toe (HP:0001845)1.81868186
107Abnormal gallbladder physiology (HP:0012438)1.80781114
108Cholecystitis (HP:0001082)1.80781114
109Impaired platelet aggregation (HP:0003540)1.80385477
110Abnormal platelet function (HP:0011869)1.80385477
111Limb hypertonia (HP:0002509)1.80032627
112Diaphragmatic weakness (HP:0009113)1.79684545
113Selective tooth agenesis (HP:0001592)1.78992377
114Abnormality of oral frenula (HP:0000190)1.76619971
115Neoplasm of head and neck (HP:0012288)1.75815668
116Esophageal neoplasm (HP:0100751)1.75815668
117Abnormality of dentin (HP:0010299)1.74748551
118Decreased motor nerve conduction velocity (HP:0003431)1.74157343
119Increased CSF lactate (HP:0002490)1.74042989
120Insomnia (HP:0100785)1.73510621
121Disproportionate tall stature (HP:0001519)1.70729727
122Abnormality of DNA repair (HP:0003254)1.70659587
123Abnormality of iron homeostasis (HP:0011031)1.70303238
124Abnormality of transition element cation homeostasis (HP:0011030)1.70123494
125Congenital hepatic fibrosis (HP:0002612)1.69695397
126Short 5th finger (HP:0009237)1.69637625
127Cerebral hypomyelination (HP:0006808)1.68644433
128Tubulointerstitial fibrosis (HP:0005576)1.68166783
129Aplastic anemia (HP:0001915)1.67459636
130Median cleft lip (HP:0000161)1.67052915
131Hepatocellular necrosis (HP:0001404)1.66202714
132Cheekbone underdevelopment (HP:0010669)1.64769721
133Hepatic necrosis (HP:0002605)1.64210487
134Gastrointestinal dysmotility (HP:0002579)1.63474188
135Oculomotor apraxia (HP:0000657)1.62429621
136Overfolded helix (HP:0000396)1.62271868
137Choroideremia (HP:0001139)1.62019001
138Mitochondrial inheritance (HP:0001427)1.61928574
139Short humerus (HP:0005792)1.61609122
140Sloping forehead (HP:0000340)1.59678576
141Spastic paraparesis (HP:0002313)1.59533747
142Hypoplastic iliac wings (HP:0002866)1.59257107
143Petechiae (HP:0000967)1.58134498
144Taurodontia (HP:0000679)1.57847603
145Abnormality of permanent molar morphology (HP:0011071)1.57847603
146Abnormality of the dental root (HP:0006486)1.57847603
147Ulnar claw (HP:0001178)1.57494634
148Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.57332524
149Brushfield spots (HP:0001088)1.57283797
150Increased serum lactate (HP:0002151)1.57158229
151Progressive macrocephaly (HP:0004481)1.57059609
152Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.56074001
153Redundant skin (HP:0001582)1.55998745
154Aplasia/hypoplasia of the humerus (HP:0006507)1.55327760
155Upper motor neuron abnormality (HP:0002127)1.54862853
156Postaxial hand polydactyly (HP:0001162)1.53401209
157Bell-shaped thorax (HP:0001591)1.51876184
158Renal dysplasia (HP:0000110)1.50034016
159Aplasia/Hypoplasia of the uvula (HP:0010293)1.49552601
160Broad distal phalanx of finger (HP:0009836)1.49079468
161Segmental peripheral demyelination/remyelination (HP:0003481)1.46358869
162Meckel diverticulum (HP:0002245)1.44556364
163Abnormality of molar (HP:0011077)1.44205578
164Abnormality of molar morphology (HP:0011070)1.44205578
165Microglossia (HP:0000171)1.44118137
166Abnormality of the renal cortex (HP:0011035)1.43871812
167Ectopic kidney (HP:0000086)1.43797012
168Abnormal drinking behavior (HP:0030082)1.43162343
169Polydipsia (HP:0001959)1.43162343
170Abnormality of the ileum (HP:0001549)1.42875402
171Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.42705036
172Short thorax (HP:0010306)1.42308109
173Dyschromatopsia (HP:0007641)1.40547918
174Neurofibrillary tangles (HP:0002185)1.38125070
175Upper limb muscle weakness (HP:0003484)1.37683789
176Abnormality of the dental pulp (HP:0006479)1.37167369
177Absent thumb (HP:0009777)1.34780041
178Abnormality of abdominal situs (HP:0011620)1.34496742
179Abdominal situs inversus (HP:0003363)1.34496742
180EMG: neuropathic changes (HP:0003445)1.33664605
181Difficulty walking (HP:0002355)1.32903410
182Abnormality of the preputium (HP:0100587)1.30929003
183Peripheral hypomyelination (HP:0007182)1.26492468
184Nephroblastoma (Wilms tumor) (HP:0002667)1.23487755
185Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.23206710
186Insidious onset (HP:0003587)1.22480819
187Termporal pattern (HP:0011008)1.22480819
188Duodenal stenosis (HP:0100867)1.22319651
189Small intestinal stenosis (HP:0012848)1.22319651
190Hand muscle atrophy (HP:0009130)1.22283750
191Abnormal biliary tract physiology (HP:0012439)1.22249949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK47.55302630
2PDK37.55302630
3TESK15.46809230
4PDK24.94175902
5PRKD34.59679331
6ICK4.42505772
7RIPK43.76953767
8CLK13.13031651
9KSR22.86389214
10NME12.72734430
11RAF12.62501815
12PNCK2.59747614
13NEK22.38069859
14STK392.32384931
15NTRK32.06894555
16WNK42.02105518
17BMPR21.86176384
18MAP3K21.83269390
19PTK2B1.81704998
20CDC71.61700367
21WEE11.60265153
22TTK1.59873408
23STK381.57036947
24NME21.54972754
25RPS6KB21.48978061
26DYRK1B1.38023224
27CDK121.37530078
28BMX1.36699441
29KSR11.36008360
30SCYL21.24105716
31TYRO31.20735182
32TSSK61.20610726
33DYRK31.16386287
34BCKDK1.14111803
35MAPK151.14026951
36BUB11.13826867
37IRAK31.12792042
38EIF2AK31.11954477
39PIM21.08801054
40CHEK21.08401705
41TESK21.04379270
42TAOK31.02702861
43WNK11.02616950
44PASK1.01751645
45MAP4K21.00959601
46STK30.97243570
47JAK20.95507602
48CDK80.88659891
49PLK10.87073265
50MAP2K10.85724216
51PLK40.84572155
52ATR0.81837640
53CHEK10.81603423
54ZAK0.81113408
55TRPM70.78242854
56PINK10.76427277
57STK38L0.76083398
58ALK0.75938731
59TEC0.75910757
60MKNK10.75047260
61MAP2K20.73299673
62JAK30.72932400
63PDK10.72521431
64MATK0.72118644
65ATM0.60847912
66MAP3K40.60785045
67MAP3K10.60457297
68CCNB10.59196737
69NUAK10.56661602
70PAK10.56576888
71BTK0.56063350
72VRK20.56036362
73MAP3K70.54161920
74TAOK20.54047318
75BRAF0.52669016
76MST40.52659886
77MTOR0.51658863
78CDK70.49930099
79ILK0.41745560
80AKT10.41656401
81AURKA0.41375865
82IRAK10.41373641
83STK160.40653414
84MAPK30.40121765
85MET0.40019801
86RPS6KA50.39341871
87PAK40.38679950
88MAPK130.36531214
89SRPK10.36022017
90EEF2K0.35654570
91CDK20.34558597
92RET0.32016457
93PRKG20.31390871
94MAPK140.31329760
95EIF2AK10.30867690
96AKT20.30296019
97AKT30.29178470
98BRSK20.27949488
99PDPK10.27538659
100CDK10.27414772
101AURKB0.26441371
102MAP2K60.26184808
103LATS20.24014137
104PLK30.23813607
105PRKAA10.23723284
106STK100.23587351
107MAPKAPK30.23419206
108DYRK20.23411225
109CSNK2A10.23376731
110CAMK1G0.22072361
111IRAK20.21697692
112EPHA20.21362861
113CSNK1D0.19279382
114PAK20.19263882
115PIM10.18809637
116CSNK2A20.18347108
117CDK40.18236082
118STK40.17311515
119MAPKAPK50.17228890
120NEK60.16599112
121MARK20.16017561
122GSK3B0.15859126
123EPHB10.14946808
124MAP3K80.14438381
125CDK150.12901972
126RPS6KA10.12667401
127LMTK20.11976429
128PRKDC0.10875960
129RPS6KB10.10777155
130BRSK10.10753615
131CSNK1E0.10386416
132CDK180.09995649
133CDK11A0.09788999
134MARK30.09508309
135BMPR1B0.09453337
136PRKCG0.09433966
137CDK140.09300486
138MAP3K60.09168002
139VRK10.08632861
140MUSK0.08559943
141MAPK10.07091856
142PBK0.06208530
143ARAF0.06178622
144NTRK20.06102795
145BCR0.05971630
146NEK10.05525609
147MAP3K100.05180382
148LATS10.04891167
149MAPK100.04737894

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.10960815
2Basal transcription factors_Homo sapiens_hsa030223.46631896
3Fatty acid biosynthesis_Homo sapiens_hsa000613.35521713
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.28859956
5Linoleic acid metabolism_Homo sapiens_hsa005913.15616121
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.11040984
7Fanconi anemia pathway_Homo sapiens_hsa034602.95328803
8Pyruvate metabolism_Homo sapiens_hsa006202.84529174
9Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.83936189
10RNA transport_Homo sapiens_hsa030132.76429889
11Ribosome_Homo sapiens_hsa030102.52943945
12Selenocompound metabolism_Homo sapiens_hsa004502.45512186
13DNA replication_Homo sapiens_hsa030302.33212698
14Dorso-ventral axis formation_Homo sapiens_hsa043202.30318154
15Mismatch repair_Homo sapiens_hsa034302.16530993
16Oocyte meiosis_Homo sapiens_hsa041142.12028438
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.10046545
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09891867
19mRNA surveillance pathway_Homo sapiens_hsa030152.09768441
20Propanoate metabolism_Homo sapiens_hsa006401.93490851
21Homologous recombination_Homo sapiens_hsa034401.83055088
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.75240524
23Glucagon signaling pathway_Homo sapiens_hsa049221.74895481
24Ether lipid metabolism_Homo sapiens_hsa005651.70323948
25Pentose phosphate pathway_Homo sapiens_hsa000301.66387427
26Cell cycle_Homo sapiens_hsa041101.59799040
27Glycerophospholipid metabolism_Homo sapiens_hsa005641.58646813
28Parkinsons disease_Homo sapiens_hsa050121.52898335
29Spliceosome_Homo sapiens_hsa030401.52424788
30Oxidative phosphorylation_Homo sapiens_hsa001901.50504932
31Base excision repair_Homo sapiens_hsa034101.49382198
32Fructose and mannose metabolism_Homo sapiens_hsa000511.47948369
33Glycerolipid metabolism_Homo sapiens_hsa005611.46177820
34Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46150118
35Maturity onset diabetes of the young_Homo sapiens_hsa049501.45271229
36Nucleotide excision repair_Homo sapiens_hsa034201.42057439
37Huntingtons disease_Homo sapiens_hsa050161.38005012
38Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.37457605
39Purine metabolism_Homo sapiens_hsa002301.35951976
40Pyrimidine metabolism_Homo sapiens_hsa002401.32826494
41RNA degradation_Homo sapiens_hsa030181.32717259
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.30574586
43Glutathione metabolism_Homo sapiens_hsa004801.25210084
44Proteasome_Homo sapiens_hsa030501.25176572
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24210285
46Nitrogen metabolism_Homo sapiens_hsa009101.23013348
47Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.21599937
48Biosynthesis of amino acids_Homo sapiens_hsa012301.20108212
49Hedgehog signaling pathway_Homo sapiens_hsa043401.18889335
50Non-homologous end-joining_Homo sapiens_hsa034501.16448037
51Arachidonic acid metabolism_Homo sapiens_hsa005901.13983936
52Carbon metabolism_Homo sapiens_hsa012001.08067212
53Sulfur relay system_Homo sapiens_hsa041221.05959060
54Acute myeloid leukemia_Homo sapiens_hsa052211.05320778
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02709520
56Olfactory transduction_Homo sapiens_hsa047401.01764969
57Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99379638
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.98516853
59Butanoate metabolism_Homo sapiens_hsa006500.98514192
60RNA polymerase_Homo sapiens_hsa030200.97973637
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.97963701
62Fat digestion and absorption_Homo sapiens_hsa049750.95787468
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95340041
64Antigen processing and presentation_Homo sapiens_hsa046120.88556462
65Mineral absorption_Homo sapiens_hsa049780.84802211
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.82065155
67N-Glycan biosynthesis_Homo sapiens_hsa005100.80401522
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77886163
69Type II diabetes mellitus_Homo sapiens_hsa049300.75421907
70PPAR signaling pathway_Homo sapiens_hsa033200.75339716
71Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74029139
72Cardiac muscle contraction_Homo sapiens_hsa042600.73782148
73Fatty acid metabolism_Homo sapiens_hsa012120.71624750
74Systemic lupus erythematosus_Homo sapiens_hsa053220.71412564
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68616745
76Alzheimers disease_Homo sapiens_hsa050100.68111247
77p53 signaling pathway_Homo sapiens_hsa041150.65224113
78Amphetamine addiction_Homo sapiens_hsa050310.63369299
79Thyroid cancer_Homo sapiens_hsa052160.62178023
80SNARE interactions in vesicular transport_Homo sapiens_hsa041300.59033904
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.56762922
82Arginine biosynthesis_Homo sapiens_hsa002200.56428316
83Basal cell carcinoma_Homo sapiens_hsa052170.56031111
84Chronic myeloid leukemia_Homo sapiens_hsa052200.53131196
85Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52829502
86Epstein-Barr virus infection_Homo sapiens_hsa051690.52696849
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52327597
88Viral carcinogenesis_Homo sapiens_hsa052030.50864794
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49189606
90Protein export_Homo sapiens_hsa030600.45951817
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45361403
92Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45235587
93HIF-1 signaling pathway_Homo sapiens_hsa040660.45039226
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43866995
95One carbon pool by folate_Homo sapiens_hsa006700.43527322
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42886575
97Metabolic pathways_Homo sapiens_hsa011000.42614955
98mTOR signaling pathway_Homo sapiens_hsa041500.42501391
99Tyrosine metabolism_Homo sapiens_hsa003500.41317582
100Chemical carcinogenesis_Homo sapiens_hsa052040.39746404
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39714462
102Cyanoamino acid metabolism_Homo sapiens_hsa004600.39478889
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39090522
104Lysine degradation_Homo sapiens_hsa003100.36770420
105Estrogen signaling pathway_Homo sapiens_hsa049150.35625653
106Arginine and proline metabolism_Homo sapiens_hsa003300.35587439
107Tight junction_Homo sapiens_hsa045300.35585980
108VEGF signaling pathway_Homo sapiens_hsa043700.35293680
109Alcoholism_Homo sapiens_hsa050340.32561350
110Fatty acid degradation_Homo sapiens_hsa000710.31048242
111Wnt signaling pathway_Homo sapiens_hsa043100.30904150
112Steroid biosynthesis_Homo sapiens_hsa001000.29072158
113ErbB signaling pathway_Homo sapiens_hsa040120.28627437
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.28390494
115Endocytosis_Homo sapiens_hsa041440.28116292
116Insulin signaling pathway_Homo sapiens_hsa049100.27389009
117AMPK signaling pathway_Homo sapiens_hsa041520.25867622
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25703194
119Legionellosis_Homo sapiens_hsa051340.25095124
120Inositol phosphate metabolism_Homo sapiens_hsa005620.24772768
121Sphingolipid metabolism_Homo sapiens_hsa006000.24545538
122Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23901572
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23312614
124Vitamin digestion and absorption_Homo sapiens_hsa049770.22948512
125Renin secretion_Homo sapiens_hsa049240.22397605
126Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.21579037
127Hippo signaling pathway_Homo sapiens_hsa043900.21067472
128Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20994330
129Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19678926
130Protein digestion and absorption_Homo sapiens_hsa049740.18668995
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18100031
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16310131
133Nicotine addiction_Homo sapiens_hsa050330.15742905
134Non-small cell lung cancer_Homo sapiens_hsa052230.15688328
135Fatty acid elongation_Homo sapiens_hsa000620.15675272
136ABC transporters_Homo sapiens_hsa020100.14116068
137Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.13545661
138Pancreatic cancer_Homo sapiens_hsa052120.13343645
139Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13292993
140Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.13200119
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13189017
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.12682109
143Bladder cancer_Homo sapiens_hsa052190.12284377
144Other glycan degradation_Homo sapiens_hsa005110.08955910
145Phototransduction_Homo sapiens_hsa047440.08601363

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