FAM179A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)7.10539899
2axonemal dynein complex assembly (GO:0070286)6.73543481
3sensory perception of chemical stimulus (GO:0007606)6.63867739
4axoneme assembly (GO:0035082)6.39575099
5protein localization to cilium (GO:0061512)5.49162117
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.73015876
7left/right axis specification (GO:0070986)4.63901750
8protein insertion into membrane (GO:0051205)4.46209563
9epithelial cilium movement (GO:0003351)4.36948722
10ventricular system development (GO:0021591)4.28853061
11detection of calcium ion (GO:0005513)4.26271225
12cilium or flagellum-dependent cell motility (GO:0001539)4.23451748
13behavioral response to nicotine (GO:0035095)4.13988576
14positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.02482386
15tryptophan catabolic process (GO:0006569)4.01643701
16indole-containing compound catabolic process (GO:0042436)4.01643701
17indolalkylamine catabolic process (GO:0046218)4.01643701
18left/right pattern formation (GO:0060972)3.98223027
19indolalkylamine metabolic process (GO:0006586)3.96849687
20regulation of cilium movement (GO:0003352)3.95785554
21membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.93819672
22chemical homeostasis within a tissue (GO:0048875)3.92407705
23fucose catabolic process (GO:0019317)3.80351419
24L-fucose metabolic process (GO:0042354)3.80351419
25L-fucose catabolic process (GO:0042355)3.80351419
26regulation of membrane repolarization (GO:0060306)3.69757679
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.68169650
28kynurenine metabolic process (GO:0070189)3.68103889
29negative regulation of cytosolic calcium ion concentration (GO:0051481)3.63949995
30glycogen catabolic process (GO:0005980)3.60971086
31regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.60263451
32membrane repolarization during action potential (GO:0086011)3.59796203
33cellular ketone body metabolic process (GO:0046950)3.53518096
34cellular component assembly involved in morphogenesis (GO:0010927)3.52857575
35regulation of heart rate by cardiac conduction (GO:0086091)3.52528594
36photoreceptor cell maintenance (GO:0045494)3.51906437
37neural tube formation (GO:0001841)3.44989162
38negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42166121
39regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.40584306
40tryptophan metabolic process (GO:0006568)3.39289700
41retinal cone cell development (GO:0046549)3.38980210
42intraciliary transport (GO:0042073)3.37718998
43negative regulation of inclusion body assembly (GO:0090084)3.37468886
44glucan catabolic process (GO:0009251)3.34104827
45detection of light stimulus involved in sensory perception (GO:0050962)3.34032124
46detection of light stimulus involved in visual perception (GO:0050908)3.34032124
47surfactant homeostasis (GO:0043129)3.32127818
48calcium-mediated signaling using intracellular calcium source (GO:0035584)3.31159948
49regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.31045503
50potassium ion export (GO:0071435)3.30956427
51response to pheromone (GO:0019236)3.26526297
52cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26133565
53membrane repolarization (GO:0086009)3.24410203
54activation of protein kinase A activity (GO:0034199)3.22303271
55ketone body metabolic process (GO:1902224)3.18701343
56cardiac conduction (GO:0061337)3.17319709
57regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.16228838
58microtubule bundle formation (GO:0001578)3.14245049
59plasma membrane repair (GO:0001778)3.13487532
60membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.13370827
61benzene-containing compound metabolic process (GO:0042537)3.13124284
62sperm motility (GO:0030317)3.10957607
63cilium morphogenesis (GO:0060271)3.09411502
64regulation of cell communication by electrical coupling (GO:0010649)3.09286461
65negative regulation of potassium ion transmembrane transport (GO:1901380)3.09259664
66nonmotile primary cilium assembly (GO:0035058)3.07968295
67negative regulation of T cell differentiation in thymus (GO:0033085)3.07965026
68cell communication by electrical coupling (GO:0010644)3.06793439
69potassium ion homeostasis (GO:0055075)3.06330163
70adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.05074860
71exogenous drug catabolic process (GO:0042738)3.05044620
72gas transport (GO:0015669)3.01745853
73cellular potassium ion homeostasis (GO:0030007)3.00303987
74cellular polysaccharide catabolic process (GO:0044247)2.97372369
75drug catabolic process (GO:0042737)2.96455216
76regulation of microtubule-based movement (GO:0060632)2.96357881
77indole-containing compound metabolic process (GO:0042430)2.95153756
78cardiac muscle contraction (GO:0060048)2.94241295
79cell communication involved in cardiac conduction (GO:0086065)2.92646198
80ventricular cardiac muscle cell action potential (GO:0086005)2.91916540
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.91513160
82regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.91329096
83thyroid hormone metabolic process (GO:0042403)2.90594821
84regulation of inclusion body assembly (GO:0090083)2.90000680
85cell projection assembly (GO:0030031)2.89631331
86centriole assembly (GO:0098534)2.89530243
87neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.89450397
88regulation of sodium ion transmembrane transport (GO:1902305)2.88454507
89rRNA catabolic process (GO:0016075)2.88320699
90polysaccharide catabolic process (GO:0000272)2.87815377
91motile cilium assembly (GO:0044458)2.87126648
92vitamin transmembrane transport (GO:0035461)2.86446763
93sulfation (GO:0051923)2.85816952
94spinal cord motor neuron differentiation (GO:0021522)2.85693012
95protein K11-linked deubiquitination (GO:0035871)2.85247558
96cardiac muscle cell action potential involved in contraction (GO:0086002)2.84862221
97regulation of skeletal muscle contraction (GO:0014819)2.83004389
98nucleoside diphosphate phosphorylation (GO:0006165)2.82710244
99regulation of sodium ion transmembrane transporter activity (GO:2000649)2.82467711
100positive regulation of potassium ion transmembrane transport (GO:1901381)2.82195132
101cardiac muscle cell action potential (GO:0086001)2.80747497
102protein polyglutamylation (GO:0018095)2.79988377
103reflex (GO:0060004)2.78969199
104neuronal action potential (GO:0019228)2.78850441
105multicellular organism reproduction (GO:0032504)2.77674885
106centriole replication (GO:0007099)2.77393457
107gamma-aminobutyric acid transport (GO:0015812)2.76437232
108behavioral response to ethanol (GO:0048149)2.76267394
109signal peptide processing (GO:0006465)2.75827283
110cornea development in camera-type eye (GO:0061303)2.74834244
111regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.74148853
112regulation of collateral sprouting (GO:0048670)2.72839939
113relaxation of cardiac muscle (GO:0055119)2.72124272
114respiratory system process (GO:0003016)2.71613790
115oxygen transport (GO:0015671)2.71339126
116negative regulation of B cell mediated immunity (GO:0002713)2.71221695
117negative regulation of immunoglobulin mediated immune response (GO:0002890)2.71221695
118one-carbon compound transport (GO:0019755)2.70525718
119brain morphogenesis (GO:0048854)2.70460051
120chemosensory behavior (GO:0007635)2.69972789
121response to xenobiotic stimulus (GO:0009410)2.69789449
122mating behavior (GO:0007617)2.68145636
123regulation of beta-amyloid formation (GO:1902003)2.68036828
124amine catabolic process (GO:0009310)2.66403499
125cellular biogenic amine catabolic process (GO:0042402)2.66403499
126smoothened signaling pathway (GO:0007224)2.66147553
127NAD biosynthetic process (GO:0009435)2.65895399
128microtubule polymerization or depolymerization (GO:0031109)2.61801251
129actin-myosin filament sliding (GO:0033275)2.58957690
130muscle filament sliding (GO:0030049)2.58957690
131determination of left/right symmetry (GO:0007368)2.57828187
132regulation of sodium ion transport (GO:0002028)2.56936001
133primary amino compound metabolic process (GO:1901160)2.56599686
134positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.55592931
135cAMP biosynthetic process (GO:0006171)2.55385920
136membrane depolarization during action potential (GO:0086010)2.55017851
137regulation of amyloid precursor protein catabolic process (GO:1902991)2.54595913
138regulation of action potential (GO:0098900)2.54466849
139sarcomere organization (GO:0045214)2.54175122
140serotonin metabolic process (GO:0042428)2.53796408
141positive regulation of oligodendrocyte differentiation (GO:0048714)2.53151529
142regulation of hippo signaling (GO:0035330)2.50965546
143female mating behavior (GO:0060180)2.50342472
144potassium ion import (GO:0010107)2.50272900
145piRNA metabolic process (GO:0034587)2.49705888
146striated muscle contraction (GO:0006941)2.49343377
147negative regulation of potassium ion transport (GO:0043267)2.49314083
148photoreceptor cell development (GO:0042461)2.48780207
149adaptation of signaling pathway (GO:0023058)2.48260697
150limb development (GO:0060173)2.47006070
151appendage development (GO:0048736)2.47006070
152striatum development (GO:0021756)2.45500776
153negative regulation of mast cell activation (GO:0033004)2.45101599
154microtubule-based movement (GO:0007018)2.44364514
155primary alcohol catabolic process (GO:0034310)2.42381780
156negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.42252211
157regulation of germinal center formation (GO:0002634)2.41659959
158positive regulation of potassium ion transport (GO:0043268)2.40740457
159cilium organization (GO:0044782)2.40377078
160multicellular organismal signaling (GO:0035637)2.40209866
161sodium ion export (GO:0071436)2.39762439
162G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.39452596
163protein K48-linked deubiquitination (GO:0071108)2.39303705
164lateral ventricle development (GO:0021670)2.38999653
165actin-mediated cell contraction (GO:0070252)2.38819047
166determination of bilateral symmetry (GO:0009855)2.37991605
167auditory receptor cell stereocilium organization (GO:0060088)2.37969164
168interkinetic nuclear migration (GO:0022027)2.37124473
169regulation of potassium ion transmembrane transport (GO:1901379)2.36935788
170cilium assembly (GO:0042384)2.36443165
171glutamate secretion (GO:0014047)2.36330996
172pyrimidine-containing compound transmembrane transport (GO:0072531)2.35854688
173neurotransmitter metabolic process (GO:0042133)2.35374821
174detection of mechanical stimulus involved in sensory perception (GO:0050974)2.33808746
175retinoic acid metabolic process (GO:0042573)2.30874209
176dopamine transport (GO:0015872)2.30492517
177regulation of corticosteroid hormone secretion (GO:2000846)2.30105871
178atrial cardiac muscle cell action potential (GO:0086014)2.30047606
179aromatic amino acid family catabolic process (GO:0009074)2.29857071
180dopamine receptor signaling pathway (GO:0007212)2.29833083
181sensory perception of smell (GO:0007608)10.9357924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.21092534
2ZNF274_21170338_ChIP-Seq_K562_Hela2.99480431
3DROSHA_22980978_ChIP-Seq_HELA_Human2.47745700
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30153504
5CTBP2_25329375_ChIP-Seq_LNCAP_Human2.28518507
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18019792
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18009507
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12190252
9IGF1R_20145208_ChIP-Seq_DFB_Human2.11976824
10SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08882627
11SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.04976314
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01476015
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01476015
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.00729388
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98461368
16FLI1_27457419_Chip-Seq_LIVER_Mouse1.97828891
17ER_23166858_ChIP-Seq_MCF-7_Human1.94907104
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.92970895
19JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90882523
20TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.90724163
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.87727638
22SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83526232
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82321448
24FUS_26573619_Chip-Seq_HEK293_Human1.82228039
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.80399577
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.78164206
27AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.77068191
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76624577
29EWS_26573619_Chip-Seq_HEK293_Human1.75919235
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.74653797
31STAT3_23295773_ChIP-Seq_U87_Human1.74557255
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.73555371
33PCGF2_27294783_Chip-Seq_ESCs_Mouse1.67650311
34EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63318541
35EZH2_27304074_Chip-Seq_ESCs_Mouse1.62801436
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62343598
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59326637
38AHR_22903824_ChIP-Seq_MCF-7_Human1.58555027
39TCF4_23295773_ChIP-Seq_U87_Human1.55195292
40ZNF263_19887448_ChIP-Seq_K562_Human1.55085526
41CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.54467952
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.53287379
43ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50812345
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49822933
45GBX2_23144817_ChIP-Seq_PC3_Human1.49333744
46RARB_27405468_Chip-Seq_BRAIN_Mouse1.49221590
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48964546
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48649594
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.48649594
50CBP_20019798_ChIP-Seq_JUKART_Human1.48622644
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48622644
52RNF2_27304074_Chip-Seq_ESCs_Mouse1.48506134
53EP300_21415370_ChIP-Seq_HL-1_Mouse1.48307845
54AR_25329375_ChIP-Seq_VCAP_Human1.46989663
55REST_21632747_ChIP-Seq_MESCs_Mouse1.42601475
56HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38013685
57MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37839747
58FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.36822125
59ARNT_22903824_ChIP-Seq_MCF-7_Human1.36590440
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.35104395
61TCF4_22108803_ChIP-Seq_LS180_Human1.35059435
62MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30030585
63PRDM14_20953172_ChIP-Seq_ESCs_Human1.29150674
64SALL1_21062744_ChIP-ChIP_HESCs_Human1.27958230
65FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27485830
66FOXA1_25329375_ChIP-Seq_VCAP_Human1.27485830
67SMAD4_21799915_ChIP-Seq_A2780_Human1.27146567
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26465845
69RUNX2_22187159_ChIP-Seq_PCA_Human1.26107609
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.25389754
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.25208921
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.25038309
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.24990769
74SOX2_19829295_ChIP-Seq_ESCs_Human1.24336020
75NANOG_19829295_ChIP-Seq_ESCs_Human1.24336020
76NFE2_27457419_Chip-Seq_LIVER_Mouse1.23720655
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.23265076
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.21405248
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.21236651
80IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20565574
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.18547859
82TBX20_22080862_ChIP-Seq_HEART_Mouse1.18199431
83TBX20_22328084_ChIP-Seq_HEART_Mouse1.18199431
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16971626
85PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16790490
86TP53_16413492_ChIP-PET_HCT116_Human1.15562169
87GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15366902
88TP53_22573176_ChIP-Seq_HFKS_Human1.14756109
89PIAS1_25552417_ChIP-Seq_VCAP_Human1.14156215
90TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13534650
91* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12580121
92NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12411811
93TAF15_26573619_Chip-Seq_HEK293_Human1.12381618
94ESR2_21235772_ChIP-Seq_MCF-7_Human1.11564038
95AR_20517297_ChIP-Seq_VCAP_Human1.11249657
96SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10839444
97KDM2B_26808549_Chip-Seq_K562_Human1.10510297
98TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10419902
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.10303765
100CDX2_22108803_ChIP-Seq_LS180_Human1.09575840
101* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09459358
102NCOR_22424771_ChIP-Seq_293T_Human1.09421860
103FLI1_21867929_ChIP-Seq_TH2_Mouse1.09258808
104REST_18959480_ChIP-ChIP_MESCs_Mouse1.09247710
105GATA3_21878914_ChIP-Seq_MCF-7_Human1.09122716
106PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09029091
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08536071
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.07365547
109CTCF_27219007_Chip-Seq_Bcells_Human1.07128089
110* SMAD4_21741376_ChIP-Seq_HESCs_Human1.06740436
111EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06345168
112FOXM1_26456572_ChIP-Seq_MCF-7_Human1.06334569
113OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05141468
114RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04649134
115ETV1_20927104_ChIP-Seq_GIST48_Human1.03652221
116CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03612277
117AR_21572438_ChIP-Seq_LNCaP_Human1.03415863
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03187872
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.03019332
120CRX_20693478_ChIP-Seq_RETINA_Mouse1.02413624
121* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02198596
122PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01915393
123SMRT_27268052_Chip-Seq_Bcells_Human1.01716405
124IRF1_19129219_ChIP-ChIP_H3396_Human1.01386674
125TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01346219
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01008703
127P53_22387025_ChIP-Seq_ESCs_Mouse1.00876574
128PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00442378
129BCAT_22108803_ChIP-Seq_LS180_Human1.00211727
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99802206
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99160313
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98378225
133TBL1_22424771_ChIP-Seq_293T_Human0.98125397
134TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97974893
135ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97205755
136HOXB7_26014856_ChIP-Seq_BT474_Human0.95309392
137* SMAD3_21741376_ChIP-Seq_HESCs_Human0.95113499
138EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91069990
139EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89733215
140LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89281831
141RING1B_27294783_Chip-Seq_NPCs_Mouse0.88857727
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.88065389
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.87301265
144BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.87151123
145RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87107302
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85550124
147RNF2_27304074_Chip-Seq_NSC_Mouse0.85407802
148KLF5_25053715_ChIP-Seq_YYC3_Human0.85111043
149* SMAD3_21741376_ChIP-Seq_EPCs_Human0.84525865
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.83679157
151LXR_22292898_ChIP-Seq_THP-1_Human0.83178012
152AR_19668381_ChIP-Seq_PC3_Human0.82250312
153SOX2_21211035_ChIP-Seq_LN229_Gbm0.82189757
154ISL1_27105846_Chip-Seq_CPCs_Mouse0.81521456
155CBX2_27304074_Chip-Seq_ESCs_Mouse0.81163740
156VDR_22108803_ChIP-Seq_LS180_Human0.80533743
157SMC4_20622854_ChIP-Seq_HELA_Human0.80304294
158TP53_20018659_ChIP-ChIP_R1E_Mouse0.80147278
159* SMAD4_21741376_ChIP-Seq_EPCs_Human0.79887173
160P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79425087
161PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79254892
162CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79097841
163RUNX1_27514584_Chip-Seq_MCF-7_Human0.78796362
164SOX9_24532713_ChIP-Seq_HFSC_Mouse0.78736504
165P300_19829295_ChIP-Seq_ESCs_Human0.78635839
166ELK4_26923725_Chip-Seq_MESODERM_Mouse0.78385116
167OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.76688918
168SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.76557792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001984_abnormal_olfaction9.67725053
2MP0004043_abnormal_pH_regulation2.95898379
3MP0000751_myopathy2.92639206
4MP0003195_calcinosis2.87001450
5MP0003136_yellow_coat_color2.75781273
6MP0000569_abnormal_digit_pigmentation2.71401129
7MP0003646_muscle_fatigue2.59481069
8MP0002837_dystrophic_cardiac_calcinosis2.55647616
9MP0005394_taste/olfaction_phenotype2.48584734
10MP0005499_abnormal_olfactory_system2.48584734
11MP0008789_abnormal_olfactory_epithelium2.39706136
12MP0004858_abnormal_nervous_system2.20604951
13MP0005645_abnormal_hypothalamus_physiol2.19688592
14MP0004036_abnormal_muscle_relaxation2.14008648
15MP0002277_abnormal_respiratory_mucosa2.12379305
16MP0004145_abnormal_muscle_electrophysio2.11672523
17MP0000749_muscle_degeneration2.06255876
18MP0004859_abnormal_synaptic_plasticity2.00883581
19MP0001968_abnormal_touch/_nociception1.99627153
20MP0004215_abnormal_myocardial_fiber1.91722265
21MP0002909_abnormal_adrenal_gland1.87787576
22MP0000383_abnormal_hair_follicle1.84599209
23MP0005253_abnormal_eye_physiology1.84356218
24MP0004084_abnormal_cardiac_muscle1.79822035
25MP0002102_abnormal_ear_morphology1.75531507
26MP0008872_abnormal_physiological_respon1.75013911
27MP0002184_abnormal_innervation1.71293740
28MP0004142_abnormal_muscle_tone1.68971284
29MP0002876_abnormal_thyroid_physiology1.68943134
30MP0004782_abnormal_surfactant_physiolog1.61668046
31MP0003635_abnormal_synaptic_transmissio1.59393235
32MP0002638_abnormal_pupillary_reflex1.56594637
33MP0001986_abnormal_taste_sensitivity1.56425326
34MP0003329_amyloid_beta_deposits1.55475723
35MP0002734_abnormal_mechanical_nocicepti1.53840331
36MP0004484_altered_response_of1.51220914
37MP0005646_abnormal_pituitary_gland1.50252343
38MP0003137_abnormal_impulse_conducting1.50104626
39MP0002822_catalepsy1.48234005
40MP0000372_irregular_coat_pigmentation1.47791662
41MP0000427_abnormal_hair_cycle1.47458554
42MP0002557_abnormal_social/conspecific_i1.45424013
43MP0001485_abnormal_pinna_reflex1.44236789
44MP0004130_abnormal_muscle_cell1.43213030
45MP0005620_abnormal_muscle_contractility1.41998912
46MP0008875_abnormal_xenobiotic_pharmacok1.39993353
47MP0004885_abnormal_endolymph1.38936355
48MP0000631_abnormal_neuroendocrine_gland1.38837340
49MP0008877_abnormal_DNA_methylation1.36730584
50MP0005174_abnormal_tail_pigmentation1.34838245
51MP0009745_abnormal_behavioral_response1.31871680
52MP0002928_abnormal_bile_duct1.31703349
53MP0005623_abnormal_meninges_morphology1.31563479
54MP0004270_analgesia1.31393047
55MP0004087_abnormal_muscle_fiber1.30714972
56MP0005330_cardiomyopathy1.28776832
57MP0002653_abnormal_ependyma_morphology1.28282995
58MP0002063_abnormal_learning/memory/cond1.27364153
59MP0005165_increased_susceptibility_to1.27008082
60MP0000747_muscle_weakness1.25913544
61MP0002272_abnormal_nervous_system1.25041098
62MP0002972_abnormal_cardiac_muscle1.24809111
63MP0002160_abnormal_reproductive_system1.24104256
64MP0001440_abnormal_grooming_behavior1.21169053
65MP0002064_seizures1.18580162
66MP0004742_abnormal_vestibular_system1.18196834
67MP0004085_abnormal_heartbeat1.17829381
68MP0002132_abnormal_respiratory_system1.15671433
69MP0002106_abnormal_muscle_physiology1.14782268
70MP0002735_abnormal_chemical_nociception1.14451380
71MP0008995_early_reproductive_senescence1.13471660
72MP0001970_abnormal_pain_threshold1.12478050
73MP0003880_abnormal_central_pattern1.09164381
74MP0005167_abnormal_blood-brain_barrier1.08921464
75MP0003252_abnormal_bile_duct1.08212916
76MP0002572_abnormal_emotion/affect_behav1.08189003
77MP0002938_white_spotting1.07386583
78MP0001486_abnormal_startle_reflex1.06027957
79MP0005085_abnormal_gallbladder_physiolo1.05840296
80MP0002168_other_aberrant_phenotype1.05528706
81MP0006276_abnormal_autonomic_nervous1.05297735
82MP0002295_abnormal_pulmonary_circulatio1.04389250
83MP0005389_reproductive_system_phenotype1.04371322
84MP0008004_abnormal_stomach_pH1.03574987
85MP0001958_emphysema1.03561957
86MP0010234_abnormal_vibrissa_follicle1.00631240
87MP0002138_abnormal_hepatobiliary_system1.00136039
88MP0002229_neurodegeneration0.99763634
89MP0010386_abnormal_urinary_bladder0.99535002
90MP0003698_abnormal_male_reproductive0.99460200
91MP0003634_abnormal_glial_cell0.98392996
92MP0002752_abnormal_somatic_nervous0.98342032
93MP0004510_myositis0.98292844
94MP0003122_maternal_imprinting0.97625991
95MP0001765_abnormal_ion_homeostasis0.97459660
96MP0003718_maternal_effect0.97024412
97MP0005195_abnormal_posterior_eye0.96718511
98MP0009046_muscle_twitch0.96560715
99MP0003075_altered_response_to0.95303704
100MP0004147_increased_porphyrin_level0.94894830
101MP0002332_abnormal_exercise_endurance0.94651024
102MP0002067_abnormal_sensory_capabilities0.94043688
103MP0004133_heterotaxia0.93946680
104MP0002882_abnormal_neuron_morphology0.93806455
105MP0000026_abnormal_inner_ear0.93455175
106MP0000230_abnormal_systemic_arterial0.93139657
107MP0001501_abnormal_sleep_pattern0.92502848
108MP0003045_fibrosis0.92402393
109MP0005410_abnormal_fertilization0.92353753
110MP0002733_abnormal_thermal_nociception0.91852380
111MP0000759_abnormal_skeletal_muscle0.91376133
112MP0005369_muscle_phenotype0.90878223
113MP0005310_abnormal_salivary_gland0.90817763
114MP0003950_abnormal_plasma_membrane0.90410111
115MP0010678_abnormal_skin_adnexa0.89989858
116MP0001324_abnormal_eye_pigmentation0.88234279
117MP0008961_abnormal_basal_metabolism0.87914858
118MP0001963_abnormal_hearing_physiology0.87729312
119MP0005395_other_phenotype0.86239401
120MP0003011_delayed_dark_adaptation0.85918983
121MP0003878_abnormal_ear_physiology0.85898215
122MP0005377_hearing/vestibular/ear_phenot0.85898215
123MP0002693_abnormal_pancreas_physiology0.85591845
124MP0006292_abnormal_olfactory_placode0.85167044
125MP0005551_abnormal_eye_electrophysiolog0.84885662
126MP0005388_respiratory_system_phenotype0.83793987
127MP0002133_abnormal_respiratory_system0.83793987
128MP0005670_abnormal_white_adipose0.83694585
129MP0002269_muscular_atrophy0.83264623
130MP0001929_abnormal_gametogenesis0.83229856
131MP0005084_abnormal_gallbladder_morpholo0.83043793
132MP0003806_abnormal_nucleotide_metabolis0.82211266
133MP0002282_abnormal_trachea_morphology0.81450059
134MP0001177_atelectasis0.81266196
135MP0003690_abnormal_glial_cell0.81188407
136MP0004019_abnormal_vitamin_homeostasis0.80760485
137MP0002736_abnormal_nociception_after0.80335378
138MP0003890_abnormal_embryonic-extraembry0.79720358
139MP0005171_absent_coat_pigmentation0.79356709
140MP0004924_abnormal_behavior0.78362376
141MP0005386_behavior/neurological_phenoty0.78362376
142MP0008775_abnormal_heart_ventricle0.78095118
143MP0002234_abnormal_pharynx_morphology0.77797762
144MP0000003_abnormal_adipose_tissue0.75876140
145MP0005385_cardiovascular_system_phenoty0.75213451
146MP0001544_abnormal_cardiovascular_syste0.75213451
147MP0000534_abnormal_ureter_morphology0.75016577
148MP0010630_abnormal_cardiac_muscle0.73030897
149MP0001542_abnormal_bone_strength0.72240766
150MP0006072_abnormal_retinal_apoptosis0.72121946
151MP0005423_abnormal_somatic_nervous0.69654348
152MP0002233_abnormal_nose_morphology0.68612629
153MP0003633_abnormal_nervous_system0.64119850
154MP0000778_abnormal_nervous_system0.63474480
155MP0001905_abnormal_dopamine_level0.61979579
156MP0004233_abnormal_muscle_weight0.61773237

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.80889787
2Abnormal respiratory motile cilium physiology (HP:0012261)8.36544465
3Abnormal ciliary motility (HP:0012262)7.42309503
4Rhinitis (HP:0012384)7.38905439
5Chronic bronchitis (HP:0004469)6.39384317
6Abnormal respiratory epithelium morphology (HP:0012253)6.39349958
7Abnormal respiratory motile cilium morphology (HP:0005938)6.39349958
8Pancreatic cysts (HP:0001737)4.96652522
9Dynein arm defect of respiratory motile cilia (HP:0012255)4.33426132
10Absent/shortened dynein arms (HP:0200106)4.33426132
11Bronchiectasis (HP:0002110)4.08722509
12Sudden death (HP:0001699)3.80549599
13Cystic liver disease (HP:0006706)3.74335449
14Exercise-induced myalgia (HP:0003738)3.65932557
15Retinal dysplasia (HP:0007973)3.60229385
16Prolonged QT interval (HP:0001657)3.59648219
17Chronic hepatic failure (HP:0100626)3.59538835
18Abnormality of the renal medulla (HP:0100957)3.52245070
19Syncope (HP:0001279)3.41911322
20Calf muscle hypertrophy (HP:0008981)3.21980164
21Palpitations (HP:0001962)3.21857451
22Central scotoma (HP:0000603)3.20696271
23Abnormality of dentin (HP:0010299)3.17010612
24Muscle hypertrophy of the lower extremities (HP:0008968)3.06314609
25Abnormality of macular pigmentation (HP:0008002)3.01408767
26Abnormality of the renal cortex (HP:0011035)2.97320624
27Muscle fiber splitting (HP:0003555)2.89378315
28Tubular atrophy (HP:0000092)2.85612705
29Atrial fibrillation (HP:0005110)2.85273481
30Ventricular fibrillation (HP:0001663)2.82777783
31Primary atrial arrhythmia (HP:0001692)2.82709527
32Congenital hepatic fibrosis (HP:0002612)2.76495796
33Congenital stationary night blindness (HP:0007642)2.74730296
34Chronic sinusitis (HP:0011109)2.74031893
35Recurrent sinusitis (HP:0011108)2.67315379
36Sclerocornea (HP:0000647)2.67084456
37Furrowed tongue (HP:0000221)2.65752343
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.65681586
39Abnormal EKG (HP:0003115)2.65293566
40Supraventricular tachycardia (HP:0004755)2.63633555
41Anencephaly (HP:0002323)2.63314024
42Postaxial foot polydactyly (HP:0001830)2.59102698
43Hyperventilation (HP:0002883)2.59014868
44Supraventricular arrhythmia (HP:0005115)2.56561813
45Exercise-induced muscle cramps (HP:0003710)2.55485672
46Hyporeflexia of lower limbs (HP:0002600)2.52986632
47Gait imbalance (HP:0002141)2.52474189
48Attenuation of retinal blood vessels (HP:0007843)2.51727888
49Gaze-evoked nystagmus (HP:0000640)2.51436042
50Abnormality of the nasal mucosa (HP:0000433)2.50111532
51Polydipsia (HP:0001959)2.49891542
52Abnormal drinking behavior (HP:0030082)2.49891542
53Male pseudohermaphroditism (HP:0000037)2.49568010
54Median cleft lip (HP:0000161)2.47772912
55Left ventricular hypertrophy (HP:0001712)2.46276805
56Congenital primary aphakia (HP:0007707)2.45085299
57Nasal polyposis (HP:0100582)2.44862836
58Myotonia (HP:0002486)2.44093516
59Bronchitis (HP:0012387)2.42825892
60Genetic anticipation (HP:0003743)2.42194003
61Abnormality of the calf musculature (HP:0001430)2.41522943
62Progressive cerebellar ataxia (HP:0002073)2.40528698
63Abnormality of permanent molar morphology (HP:0011071)2.36367242
64Abnormality of the dental root (HP:0006486)2.36367242
65Taurodontia (HP:0000679)2.36367242
66Medial flaring of the eyebrow (HP:0010747)2.33680166
67Tubulointerstitial nephritis (HP:0001970)2.33199958
68Decreased central vision (HP:0007663)2.32787488
69Abnormality of the dental pulp (HP:0006479)2.27657872
70Pancreatic fibrosis (HP:0100732)2.27363603
71Interstitial pulmonary disease (HP:0006530)2.26796104
72Abolished electroretinogram (ERG) (HP:0000550)2.24818538
73Muscle fiber inclusion bodies (HP:0100299)2.22740213
74Chronic otitis media (HP:0000389)2.21752303
75Nephrogenic diabetes insipidus (HP:0009806)2.21142284
76Supernumerary spleens (HP:0009799)2.19496037
77Abnormality of molar (HP:0011077)2.19234011
78Abnormality of molar morphology (HP:0011070)2.19234011
79Molar tooth sign on MRI (HP:0002419)2.19113709
80Abnormality of midbrain morphology (HP:0002418)2.19113709
81Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18666469
82Myokymia (HP:0002411)2.18210911
83Vaginal atresia (HP:0000148)2.14368106
84Abnormal rod and cone electroretinograms (HP:0008323)2.13892179
85Atrioventricular block (HP:0001678)2.12733608
86Genital tract atresia (HP:0001827)2.11030410
87Ventricular arrhythmia (HP:0004308)2.10002250
88Type 1 muscle fiber predominance (HP:0003803)2.05007663
89Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.03427677
90Increased variability in muscle fiber diameter (HP:0003557)2.00864192
91Myoglobinuria (HP:0002913)1.97970576
92Supranuclear gaze palsy (HP:0000605)1.97311739
93Scotoma (HP:0000575)1.96877429
94Type II lissencephaly (HP:0007260)1.96723633
95Abnormal biliary tract physiology (HP:0012439)1.96236749
96Bile duct proliferation (HP:0001408)1.96236749
97Absent speech (HP:0001344)1.96164160
98Megalencephaly (HP:0001355)1.94336209
99Right ventricular cardiomyopathy (HP:0011663)1.93691367
100Heart block (HP:0012722)1.93231503
101Limb dystonia (HP:0002451)1.93218845
102Ventricular tachycardia (HP:0004756)1.90643872
103EMG: myopathic abnormalities (HP:0003458)1.88635019
104Postaxial hand polydactyly (HP:0001162)1.87596310
105Oculomotor apraxia (HP:0000657)1.87210385
106Abnormality of skeletal muscle fiber size (HP:0012084)1.85836421
107Polyuria (HP:0000103)1.84733333
108Large for gestational age (HP:0001520)1.84351126
109Congenital sensorineural hearing impairment (HP:0008527)1.84273995
110Bundle branch block (HP:0011710)1.83147318
111Aplasia/Hypoplasia of the spleen (HP:0010451)1.82771372
112Infertility (HP:0000789)1.82396970
113True hermaphroditism (HP:0010459)1.82003829
114Clumsiness (HP:0002312)1.81760706
115Tubulointerstitial abnormality (HP:0001969)1.81222681
116Abnormal atrioventricular conduction (HP:0005150)1.81093503
117Tachypnea (HP:0002789)1.81002893
118Muscle stiffness (HP:0003552)1.80232910
119Preaxial hand polydactyly (HP:0001177)1.79431143
120Retinitis pigmentosa (HP:0000510)1.79278919
121Febrile seizures (HP:0002373)1.79126762
122Difficulty climbing stairs (HP:0003551)1.76797410
123Anosmia (HP:0000458)1.75165229
124Aplasia involving bones of the upper limbs (HP:0009823)1.74722943
125Aplasia of the phalanges of the hand (HP:0009802)1.74722943
126Aplasia involving bones of the extremities (HP:0009825)1.74722943
127Rimmed vacuoles (HP:0003805)1.73766739
128Hyperkalemia (HP:0002153)1.72680085
129Asplenia (HP:0001746)1.71990323
130Short nail (HP:0001799)1.71836439
131Aplasia/Hypoplasia of the tibia (HP:0005772)1.71383376
132Congenital, generalized hypertrichosis (HP:0004540)1.71255760
133Abnormality of renin-angiotensin system (HP:0000847)1.70952669
134Occipital encephalocele (HP:0002085)1.70313750
135Keratoconus (HP:0000563)1.70071045
136Increased corneal curvature (HP:0100692)1.70071045
137Broad-based gait (HP:0002136)1.69925577
138Inability to walk (HP:0002540)1.69920093
139Hyperactive renin-angiotensin system (HP:0000841)1.69292792
140Esophageal neoplasm (HP:0100751)1.69159112
141Neoplasm of head and neck (HP:0012288)1.69159112
142Decreased circulating renin level (HP:0003351)1.68659745
143Poor coordination (HP:0002370)1.68365917
144Bony spicule pigmentary retinopathy (HP:0007737)1.66249880
145Nemaline bodies (HP:0003798)1.65943940
146Protruding tongue (HP:0010808)1.64540659
147Nephronophthisis (HP:0000090)1.63978613
148Lipoatrophy (HP:0100578)1.63957941
149Recurrent otitis media (HP:0000403)1.63595601
150Stage 5 chronic kidney disease (HP:0003774)1.63457994
151Difficulty running (HP:0009046)1.62739108
152Constricted visual fields (HP:0001133)1.61236858
153Renal cortical cysts (HP:0000803)1.61162988
154Male infertility (HP:0003251)1.61066365
155Pendular nystagmus (HP:0012043)1.57738763
156Tubulointerstitial fibrosis (HP:0005576)1.57186421
157Fair hair (HP:0002286)1.54268954
158Cerebellar dysplasia (HP:0007033)1.52128321
159Progressive inability to walk (HP:0002505)1.51788557
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.49855463
161Abnormality of alanine metabolism (HP:0010916)1.49855463
162Hyperalaninemia (HP:0003348)1.49855463
163Focal motor seizures (HP:0011153)1.48761846
164Stomach cancer (HP:0012126)1.45640317

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.94070300
2PHKG26.05422403
3PHKG16.05422403
4MAPK155.71097241
5LMTK23.92217736
6BMPR1B3.04692245
7ADRBK22.93573848
8OBSCN2.86419756
9INSRR2.65350341
10ACVR1B2.56160057
11TRIB32.47138560
12TAOK32.31365154
13WNK32.12430238
14TTN2.05440345
15MAP4K22.01037093
16PAK32.00707582
17ZAK1.96495654
18MAPK131.77889369
19PNCK1.69989947
20STK241.68374208
21CAMK2D1.65331966
22WNK41.61184001
23NTRK21.60324558
24OXSR11.60293385
25TLK11.57863463
26PDK41.44629305
27PDK31.44629305
28CASK1.43171426
29TXK1.40840913
30MYLK1.32695191
31CAMK2G1.24054246
32DAPK21.22583613
33STK391.19533670
34CAMK2B1.17724387
35MAP3K91.15949615
36MAP3K21.14053348
37MKNK21.13742822
38PRKD31.11720104
39FER1.11461566
40ERBB31.09747148
41NTRK31.09278708
42ICK1.02970802
43MAP2K71.01880579
44ARAF0.99713982
45MUSK0.97494467
46TGFBR10.97167517
47DMPK0.95937529
48MAPKAPK30.95559502
49ILK0.94148621
50TIE10.94025720
51MAP3K40.89537108
52TEC0.88608642
53ROCK20.88211138
54PRKCG0.87653332
55RPS6KA20.87434029
56BRSK20.87085399
57HIPK20.86386827
58CAMK1G0.83605921
59GRK10.83262608
60TRPM70.82235647
61CAMK2A0.82185007
62MAP2K40.81923420
63GRK50.81756946
64BCKDK0.80302836
65MINK10.79347789
66ROCK10.78040616
67PINK10.77856273
68PRKD10.77072082
69NME10.74278930
70CAMKK20.73833467
71SIK10.73589222
72MAP3K120.70166507
73CAMK1D0.69983453
74PRKCQ0.69449622
75TYRO30.67824927
76NLK0.65474342
77LRRK20.65455008
78MAP2K60.61705678
79IKBKB0.60619991
80CDK50.59907202
81SGK2230.59676454
82SGK4940.59676454
83PIK3CA0.57147312
84STK30.56864624
85STK380.56725372
86EPHA30.56251489
87PKN10.55757462
88BCR0.55329497
89PAK60.55116339
90IRAK20.54632573
91ITK0.54617174
92TNK20.54473922
93MAPKAPK50.53876845
94LATS10.53068832
95KIT0.53040937
96CSNK1A1L0.52816004
97MAP3K70.52694845
98CSNK1G30.52641118
99MST40.52050319
100PRKCH0.51655226
101CSNK1G20.50819897
102CSNK1G10.50204573
103STK38L0.49871067
104PTK2B0.49805371
105PDK20.48859343
106PRKCE0.47778231
107SIK20.47706634
108NTRK10.47359430
109DYRK20.46389746
110VRK10.46379455
111PLK20.46205912
112SGK30.45859719
113AKT30.45646190
114EPHA40.45218394
115ERBB20.44352136
116CHUK0.43795451
117PRKACA0.43738763
118SGK20.43462297
119IRAK10.43112552
120RIPK10.42195475
121STK110.42065909
122WEE10.42058678
123MARK10.41794735
124TGFBR20.41782903
125FGFR20.41314244
126CDC42BPA0.41178330
127PRKCA0.40217275
128PDPK10.39874722
129CAMKK10.39708948
130GRK70.38768300
131EPHB10.38174794
132MAP2K20.38023761
133PRKACG0.37582759
134PRKAA20.36747598
135RPS6KA50.35983815
136MAP2K10.35692456
137PRKG10.35526579
138MAPK120.34734877
139PIK3CG0.33945562
140PRKAA10.33366458
141NUAK10.33320455
142ADRBK10.32596505
143SGK10.31655659
144CAMK10.31400556
145TNIK0.30861180
146FGR0.30520352
147PRKCI0.28973317
148PRKCZ0.26943593
149MKNK10.26692657
150CDK190.26435811
151ABL10.25424939
152IGF1R0.25367609
153CSNK1D0.25080635
154CSNK1A10.24051356

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047406.81124120
2Linoleic acid metabolism_Homo sapiens_hsa005912.79362554
3Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.51512965
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.38045531
5Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.37519071
6Chemical carcinogenesis_Homo sapiens_hsa052042.34414006
7Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.33796979
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.22754785
9Tryptophan metabolism_Homo sapiens_hsa003802.08068362
10Nitrogen metabolism_Homo sapiens_hsa009102.05719609
11Cardiac muscle contraction_Homo sapiens_hsa042602.01690713
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.00008087
13Insulin secretion_Homo sapiens_hsa049111.92423567
14Gastric acid secretion_Homo sapiens_hsa049711.90451027
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.82407650
16Maturity onset diabetes of the young_Homo sapiens_hsa049501.79625938
17Taste transduction_Homo sapiens_hsa047421.79517750
18Dilated cardiomyopathy_Homo sapiens_hsa054141.75768599
19Circadian entrainment_Homo sapiens_hsa047131.72520245
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.71853654
21Steroid hormone biosynthesis_Homo sapiens_hsa001401.68763030
22Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63980930
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.59289131
24Retinol metabolism_Homo sapiens_hsa008301.58392613
25GABAergic synapse_Homo sapiens_hsa047271.57013866
26Ether lipid metabolism_Homo sapiens_hsa005651.53373047
27Morphine addiction_Homo sapiens_hsa050321.53246202
28Synaptic vesicle cycle_Homo sapiens_hsa047211.52649915
29Salivary secretion_Homo sapiens_hsa049701.51702904
30Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.49348251
31Phototransduction_Homo sapiens_hsa047441.43400291
32Calcium signaling pathway_Homo sapiens_hsa040201.39326330
33Renin secretion_Homo sapiens_hsa049241.38718718
34Parkinsons disease_Homo sapiens_hsa050121.37397465
35Fatty acid biosynthesis_Homo sapiens_hsa000611.36240933
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.35218087
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35186556
38Oxidative phosphorylation_Homo sapiens_hsa001901.34656106
39Thyroid hormone synthesis_Homo sapiens_hsa049181.33574927
40Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33419079
41Dopaminergic synapse_Homo sapiens_hsa047281.31241443
42cAMP signaling pathway_Homo sapiens_hsa040241.29446249
43Vibrio cholerae infection_Homo sapiens_hsa051101.28805814
44Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28475801
45Glutamatergic synapse_Homo sapiens_hsa047241.26751111
46Propanoate metabolism_Homo sapiens_hsa006401.26706661
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.26417319
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.25815192
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.25300646
50Amphetamine addiction_Homo sapiens_hsa050311.24287352
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.22807561
52Arachidonic acid metabolism_Homo sapiens_hsa005901.21758223
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19839222
54Collecting duct acid secretion_Homo sapiens_hsa049661.18224760
55Cholinergic synapse_Homo sapiens_hsa047251.17705312
56Selenocompound metabolism_Homo sapiens_hsa004501.16848971
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.15828688
58GnRH signaling pathway_Homo sapiens_hsa049121.14317406
59Peroxisome_Homo sapiens_hsa041461.12558699
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11105338
61Alzheimers disease_Homo sapiens_hsa050101.08916598
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.08052872
63Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06903271
64Homologous recombination_Homo sapiens_hsa034401.06263042
65Huntingtons disease_Homo sapiens_hsa050161.05363488
66Estrogen signaling pathway_Homo sapiens_hsa049151.05358819
67Glucagon signaling pathway_Homo sapiens_hsa049221.03201215
68Oxytocin signaling pathway_Homo sapiens_hsa049211.03070139
69Tyrosine metabolism_Homo sapiens_hsa003501.02697018
70Butanoate metabolism_Homo sapiens_hsa006501.01595033
71Cocaine addiction_Homo sapiens_hsa050301.00733987
72Glycerolipid metabolism_Homo sapiens_hsa005611.00018781
73Melanogenesis_Homo sapiens_hsa049160.98765610
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.96573056
75Asthma_Homo sapiens_hsa053100.94950750
76Bile secretion_Homo sapiens_hsa049760.92758086
77Graft-versus-host disease_Homo sapiens_hsa053320.91905004
78Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91815952
79Ovarian steroidogenesis_Homo sapiens_hsa049130.88177330
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.87743257
81Fatty acid degradation_Homo sapiens_hsa000710.86470071
82Nicotine addiction_Homo sapiens_hsa050330.85102199
83Type I diabetes mellitus_Homo sapiens_hsa049400.84685485
84Long-term potentiation_Homo sapiens_hsa047200.84467096
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.84253447
86Fanconi anemia pathway_Homo sapiens_hsa034600.83210077
87Pyruvate metabolism_Homo sapiens_hsa006200.81884251
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81475052
89Phenylalanine metabolism_Homo sapiens_hsa003600.77953953
90Insulin signaling pathway_Homo sapiens_hsa049100.77195989
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76859660
92beta-Alanine metabolism_Homo sapiens_hsa004100.72133227
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71729123
94RNA polymerase_Homo sapiens_hsa030200.71719666
95Starch and sucrose metabolism_Homo sapiens_hsa005000.70480195
96Gap junction_Homo sapiens_hsa045400.70256238
97Glutathione metabolism_Homo sapiens_hsa004800.69331132
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69124560
99Mineral absorption_Homo sapiens_hsa049780.68856929
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67927015
101Allograft rejection_Homo sapiens_hsa053300.67131759
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.66775611
103Serotonergic synapse_Homo sapiens_hsa047260.65960867
104Circadian rhythm_Homo sapiens_hsa047100.65836702
105Autoimmune thyroid disease_Homo sapiens_hsa053200.64442069
106PPAR signaling pathway_Homo sapiens_hsa033200.64004056
107Basal transcription factors_Homo sapiens_hsa030220.63571495
108Regulation of autophagy_Homo sapiens_hsa041400.63206018
109Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62841832
110Fatty acid metabolism_Homo sapiens_hsa012120.62710517
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.62124456
112Insulin resistance_Homo sapiens_hsa049310.61695885
113Pancreatic secretion_Homo sapiens_hsa049720.57227972
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56328757
115Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55797468
116Primary immunodeficiency_Homo sapiens_hsa053400.55711884
117Type II diabetes mellitus_Homo sapiens_hsa049300.51976463
118Axon guidance_Homo sapiens_hsa043600.49152345
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.48328636
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.48217798
121Metabolic pathways_Homo sapiens_hsa011000.46946250
122Tight junction_Homo sapiens_hsa045300.46840744
123Vitamin digestion and absorption_Homo sapiens_hsa049770.46452716
124Purine metabolism_Homo sapiens_hsa002300.46092377
125Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44367630
126Long-term depression_Homo sapiens_hsa047300.43538141
127Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43098424
128Carbon metabolism_Homo sapiens_hsa012000.42956809
129Sphingolipid metabolism_Homo sapiens_hsa006000.41054335
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38923246
131Dorso-ventral axis formation_Homo sapiens_hsa043200.38643436
132Rap1 signaling pathway_Homo sapiens_hsa040150.38478781
133Histidine metabolism_Homo sapiens_hsa003400.38261065
134Sulfur metabolism_Homo sapiens_hsa009200.37606904
135Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37240316
136Protein export_Homo sapiens_hsa030600.36751866
137Fat digestion and absorption_Homo sapiens_hsa049750.36281155
138Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35628651
139MAPK signaling pathway_Homo sapiens_hsa040100.35320853
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.35113112
141Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.34659036
142Prion diseases_Homo sapiens_hsa050200.33974444
143Alcoholism_Homo sapiens_hsa050340.32599063
144Ras signaling pathway_Homo sapiens_hsa040140.31517153
145Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30960671
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.29777857
147ABC transporters_Homo sapiens_hsa020100.29064448
148Amoebiasis_Homo sapiens_hsa051460.28421239
149Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28213826
150Caffeine metabolism_Homo sapiens_hsa002320.26415747

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