FAM180A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)9.50145961
2negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)9.01685744
3limb bud formation (GO:0060174)9.01481465
4positive regulation of extracellular matrix organization (GO:1903055)8.46055055
5protein heterotrimerization (GO:0070208)7.69424658
6collagen fibril organization (GO:0030199)7.41559651
7sequestering of extracellular ligand from receptor (GO:0035581)7.37164607
8sphingomyelin metabolic process (GO:0006684)7.02074308
9proteoglycan metabolic process (GO:0006029)6.61346897
10embryonic skeletal joint morphogenesis (GO:0060272)6.44422601
11cartilage development (GO:0051216)6.27124564
12chondroitin sulfate biosynthetic process (GO:0030206)6.06831764
13adhesion of symbiont to host cell (GO:0044650)5.83975427
14virion attachment to host cell (GO:0019062)5.83975427
15replacement ossification (GO:0036075)5.80031753
16endochondral ossification (GO:0001958)5.80031753
17endothelial cell morphogenesis (GO:0001886)5.69316355
18regulation of extracellular matrix disassembly (GO:0010715)5.69131322
19keratan sulfate biosynthetic process (GO:0018146)5.65165638
20type B pancreatic cell proliferation (GO:0044342)5.61601310
21extracellular matrix assembly (GO:0085029)5.50634906
22nucleotide-sugar biosynthetic process (GO:0009226)5.45878266
23chondrocyte differentiation (GO:0002062)5.41503029
24positive regulation of chondrocyte differentiation (GO:0032332)5.27994678
25protein retention in ER lumen (GO:0006621)5.15868756
26blood vessel maturation (GO:0001955)5.12016357
27cellular glucuronidation (GO:0052695)5.07513982
28collagen catabolic process (GO:0030574)5.07094104
29regulation of extracellular matrix organization (GO:1903053)4.98319537
30regulation of plasminogen activation (GO:0010755)4.96943162
31skeletal system development (GO:0001501)4.96692714
32kidney mesenchyme development (GO:0072074)4.90546344
33maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.84556918
34iron ion import (GO:0097286)4.81876565
35collagen metabolic process (GO:0032963)4.81341434
36extracellular negative regulation of signal transduction (GO:1900116)4.77769447
37extracellular regulation of signal transduction (GO:1900115)4.77769447
38adhesion of symbiont to host (GO:0044406)4.76162558
39negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)4.70905205
40bone trabecula formation (GO:0060346)4.66231966
41multicellular organismal catabolic process (GO:0044243)4.64660160
42positive regulation of cartilage development (GO:0061036)4.62646457
43skin morphogenesis (GO:0043589)4.60881122
44keratan sulfate metabolic process (GO:0042339)4.59838908
45mesenchymal-epithelial cell signaling (GO:0060638)4.56874594
46uronic acid metabolic process (GO:0006063)4.56210365
47glucuronate metabolic process (GO:0019585)4.56210365
48cell migration involved in heart development (GO:0060973)4.56091565
49hypotonic response (GO:0006971)4.56003293
50multicellular organismal macromolecule metabolic process (GO:0044259)4.49972526
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.40813739
52response to BMP (GO:0071772)4.40184151
53cellular response to BMP stimulus (GO:0071773)4.40184151
54endocardial cushion morphogenesis (GO:0003203)4.36236028
55regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.30917057
56multicellular organismal metabolic process (GO:0044236)4.30895927
57lipopolysaccharide biosynthetic process (GO:0009103)4.26299581
58dermatan sulfate biosynthetic process (GO:0030208)4.24364164
59peptidyl-proline hydroxylation (GO:0019511)4.23593698
60glycoprotein metabolic process (GO:0009100)4.21913385
61extracellular fibril organization (GO:0043206)4.19199172
62metanephric mesenchyme development (GO:0072075)4.18777130
63negative regulation of leukocyte chemotaxis (GO:0002689)4.06067507
64connective tissue development (GO:0061448)4.03089283
65cellular response to vitamin (GO:0071295)3.99921149
66short-term memory (GO:0007614)3.97814839
67dermatan sulfate metabolic process (GO:0030205)3.97120390
68glycosaminoglycan biosynthetic process (GO:0006024)3.96778638
69negative regulation of smooth muscle cell migration (GO:0014912)3.93409282
70negative regulation of BMP signaling pathway (GO:0030514)3.93382542
71UDP-N-acetylglucosamine metabolic process (GO:0006047)3.93354262
72negative regulation of gluconeogenesis (GO:0045721)3.93015350
73extracellular matrix disassembly (GO:0022617)3.92888947
74aminoglycan biosynthetic process (GO:0006023)3.91453398
75negative regulation of smooth muscle cell differentiation (GO:0051151)3.90375068
76cell migration involved in sprouting angiogenesis (GO:0002042)3.88439189
77negative regulation of nitric-oxide synthase activity (GO:0051001)3.83758328
78regulation of chondrocyte differentiation (GO:0032330)3.82362115
79substrate-dependent cell migration (GO:0006929)3.82299231
80regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.79697699
81response to gravity (GO:0009629)3.79591178
82positive regulation of protein autophosphorylation (GO:0031954)3.78843411
83lymphangiogenesis (GO:0001946)3.77970391
84fibril organization (GO:0097435)3.71873144
85chondrocyte proliferation (GO:0035988)3.71232712
86detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.70623218
87myelin assembly (GO:0032288)3.64303620
88regulation of cartilage development (GO:0061035)3.63116875
89chondroitin sulfate metabolic process (GO:0030204)3.61412533
90sulfur compound catabolic process (GO:0044273)3.60966961
91COPII vesicle coating (GO:0048208)3.60720026
92lipopolysaccharide metabolic process (GO:0008653)3.58323205
93glycosaminoglycan catabolic process (GO:0006027)3.56345241
94positive regulation of blood vessel endothelial cell migration (GO:0043536)3.54645722
95cellular response to vitamin D (GO:0071305)3.50831308
96heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.49597880
97mesenchyme morphogenesis (GO:0072132)3.49515863
98regulation of integrin-mediated signaling pathway (GO:2001044)3.48377129
99embryonic cranial skeleton morphogenesis (GO:0048701)3.46142364
100negative regulation of cartilage development (GO:0061037)3.45900745
101positive regulation of hormone biosynthetic process (GO:0046886)3.41048571
102positive regulation of fibroblast migration (GO:0010763)3.40923005
103endodermal cell differentiation (GO:0035987)3.39119718
104venous blood vessel morphogenesis (GO:0048845)3.38504372
105proteoglycan biosynthetic process (GO:0030166)3.36956581
106cell adhesion mediated by integrin (GO:0033627)3.36229841
107aminoglycan catabolic process (GO:0006026)3.35771248
108activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)3.34880831
109smooth muscle tissue development (GO:0048745)3.33814555
110protein hydroxylation (GO:0018126)3.31035204
111middle ear morphogenesis (GO:0042474)3.29229779
112ossification (GO:0001503)3.26468822
113negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.25678393
114negative regulation of chondrocyte differentiation (GO:0032331)3.22657905
115vascular endothelial growth factor signaling pathway (GO:0038084)3.21241905
116glomerular basement membrane development (GO:0032836)3.20290083
117extracellular matrix organization (GO:0030198)3.19994121
118extracellular structure organization (GO:0043062)3.18922058
119regulation of type B pancreatic cell apoptotic process (GO:2000674)3.17042694
120nucleotide-sugar metabolic process (GO:0009225)3.16240039
121regulation of metalloenzyme activity (GO:0048552)3.14692139
122otic vesicle formation (GO:0030916)3.13849379
123positive regulation of catecholamine secretion (GO:0033605)3.13470523
124cellular response to amino acid stimulus (GO:0071230)3.13469651
125positive regulation of axon extension (GO:0045773)3.13141479
126bone development (GO:0060348)3.13128212
127substrate adhesion-dependent cell spreading (GO:0034446)3.11918546
128regulation of steroid hormone biosynthetic process (GO:0090030)3.08941385
129negative regulation of axon extension involved in axon guidance (GO:0048843)3.08409713
130negative regulation of glycogen biosynthetic process (GO:0045719)3.08379251
131negative regulation of endothelial cell proliferation (GO:0001937)3.06890501
132cellular response to interferon-alpha (GO:0035457)3.05522307
133sprouting angiogenesis (GO:0002040)3.04666545
134mucopolysaccharide metabolic process (GO:1903510)3.04571633
135regulation of bone mineralization (GO:0030500)3.01783915
136negative regulation of osteoblast proliferation (GO:0033689)3.01095476
137positive regulation of male gonad development (GO:2000020)2.97070288
138negative regulation of glycogen metabolic process (GO:0070874)2.94372322
139regulation of response to osmotic stress (GO:0047484)2.94317903
140protein localization to cell surface (GO:0034394)2.94100537
141chondroitin sulfate catabolic process (GO:0030207)2.94009128
142COPI coating of Golgi vesicle (GO:0048205)2.92925670
143Golgi transport vesicle coating (GO:0048200)2.92925670
144stress fiber assembly (GO:0043149)2.90663587
145heart valve formation (GO:0003188)2.88462371
146barbed-end actin filament capping (GO:0051016)2.87374625
147tooth mineralization (GO:0034505)2.87346100
148positive regulation of endothelial cell apoptotic process (GO:2000353)2.87290763
149embryonic viscerocranium morphogenesis (GO:0048703)2.85408873
150regulation of cell maturation (GO:1903429)2.85012104
151endocardial cushion development (GO:0003197)2.83832319
152negative regulation of chemokine production (GO:0032682)2.83067682
153negative regulation of nitric oxide biosynthetic process (GO:0045019)2.81718719
154regulation of male gonad development (GO:2000018)2.79915190
155peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.78503602
156positive regulation of osteoblast proliferation (GO:0033690)2.77219227
157glycoprotein biosynthetic process (GO:0009101)2.75629376
158hyaluronan catabolic process (GO:0030214)2.74218441
159actin filament depolymerization (GO:0030042)2.72344447
160retina vasculature morphogenesis in camera-type eye (GO:0061299)2.69389284
161regulation of BMP signaling pathway (GO:0030510)2.68194436
162negative regulation of biomineral tissue development (GO:0070168)2.67705876
163axon extension involved in axon guidance (GO:0048846)2.66802467
164neuron projection extension involved in neuron projection guidance (GO:1902284)2.66802467
165negative regulation of homotypic cell-cell adhesion (GO:0034111)2.64855048
166wound healing, spreading of epidermal cells (GO:0035313)2.64645961
167heparan sulfate proteoglycan metabolic process (GO:0030201)2.61440225
168negative regulation of axon guidance (GO:1902668)2.60479576
169cartilage development involved in endochondral bone morphogenesis (GO:0060351)13.3391306
170cartilage condensation (GO:0001502)12.3626655
171cell aggregation (GO:0098743)12.3626655
172keratan sulfate catabolic process (GO:0042340)11.5060309
173chondrocyte development (GO:0002063)11.5050467

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.73446964
2AR_21572438_ChIP-Seq_LNCaP_Human5.47631269
3TP63_17297297_ChIP-ChIP_HaCaT_Human5.01832251
4SMAD_19615063_ChIP-ChIP_OVARY_Human3.99954891
5GATA1_22025678_ChIP-Seq_K562_Human3.70136107
6ESR1_21235772_ChIP-Seq_MCF-7_Human3.32430844
7PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.76328321
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.44501405
9ESR2_21235772_ChIP-Seq_MCF-7_Human2.33564017
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24063287
11CJUN_26792858_Chip-Seq_BT549_Human2.23359650
12TP53_16413492_ChIP-PET_HCT116_Human2.14711492
13GBX2_23144817_ChIP-Seq_PC3_Human2.07195094
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01121434
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99369893
16ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.96149426
17EED_16625203_ChIP-ChIP_MESCs_Mouse1.94138486
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93654671
19FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90960951
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.86299040
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80275259
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79397593
23HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74164322
24SALL1_21062744_ChIP-ChIP_HESCs_Human1.74130680
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.73538740
26RXR_22108803_ChIP-Seq_LS180_Human1.70692500
27TP53_18474530_ChIP-ChIP_U2OS_Human1.69383319
28ZNF217_24962896_ChIP-Seq_MCF-7_Human1.68761589
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63911630
30CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.63844522
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.62863199
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62450775
33JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57436628
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55456994
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52691709
36MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.52270336
37NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52106771
38NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52106771
39VDR_24787735_ChIP-Seq_THP-1_Human1.50981511
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.49191120
41SOX2_20726797_ChIP-Seq_SW620_Human1.47755216
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36462314
43* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35762003
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35540680
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.32998984
46JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.31720260
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.30425523
48CLOCK_20551151_ChIP-Seq_293T_Human1.30022363
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29454374
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29454374
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28850943
52EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28850943
53TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.28110747
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27454659
55BRD4_25478319_ChIP-Seq_HGPS_Human1.27082932
56SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26949348
57SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.25824857
58EGR1_19032775_ChIP-ChIP_M12_Human1.24097813
59SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23946466
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22537073
61GATA3_24758297_ChIP-Seq_MCF-7_Human1.20150125
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.19927582
63JARID2_20075857_ChIP-Seq_MESCs_Mouse1.19424939
64CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19220894
65EZH2_27294783_Chip-Seq_NPCs_Mouse1.17910476
66SMAD4_21799915_ChIP-Seq_A2780_Human1.15312626
67PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15050585
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.14608456
69SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14512963
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13187398
71* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13142319
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13012479
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.12728368
74SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09393508
75SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08697635
76SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08697635
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06941314
78SA1_22415368_ChIP-Seq_MEFs_Mouse1.06249454
79* TP53_23651856_ChIP-Seq_MEFs_Mouse1.05913528
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04999814
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.04302244
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03478088
83AHR_22903824_ChIP-Seq_MCF-7_Human1.03281725
84WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03278789
85PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human1.02361127
86NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01343658
87TP53_22127205_ChIP-Seq_IMR90_Human1.01076562
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00593915
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00099615
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99381683
91RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98868494
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.98383640
93P300_19829295_ChIP-Seq_ESCs_Human0.98186240
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.97982839
95EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96268652
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95536892
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.95354062
98EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94523116
99GATA2_21666600_ChIP-Seq_HMVEC_Human0.94036023
100BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.93636885
101KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93240599
102CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92607924
103JUN_21703547_ChIP-Seq_K562_Human0.92074191
104* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91743834
105CDX2_20551321_ChIP-Seq_CACO-2_Human0.91440297
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90996068
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90980443
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.90647462
109PIAS1_25552417_ChIP-Seq_VCAP_Human0.90310955
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90237962
111UBF1/2_26484160_Chip-Seq_HMECs_Human0.88442308
112EP300_21415370_ChIP-Seq_HL-1_Mouse0.88020977
113TCF4_22108803_ChIP-Seq_LS180_Human0.87911176
114SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87688405
115TP63_23658742_ChIP-Seq_EP156T_Human0.87667632
116P53_22387025_ChIP-Seq_ESCs_Mouse0.86687746
117MTF2_20144788_ChIP-Seq_MESCs_Mouse0.86570479
118CTCF_21964334_Chip-Seq_Bcells_Human0.86185345
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86044993
120SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85585203
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.85119332
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.85069281
123CRX_20693478_ChIP-Seq_RETINA_Mouse0.84881772
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84532967
125TBX20_22328084_ChIP-Seq_HEART_Mouse0.84323723
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.84323723
127TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.84243439
128NFI_21473784_ChIP-Seq_ESCs_Mouse0.81607227
129KDM2B_26808549_Chip-Seq_REH_Human0.81519876
130FOXO3_23340844_ChIP-Seq_DLD1_Human0.81261767
131NOTCH1_21737748_ChIP-Seq_TLL_Human0.80667814
132BMI1_23680149_ChIP-Seq_NPCS_Mouse0.80645333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004134_abnormal_chest_morphology6.32100216
2MP0002933_joint_inflammation5.95082971
3MP0002282_abnormal_trachea_morphology5.51620449
4MP0005503_abnormal_tendon_morphology4.64597696
5MP0003646_muscle_fatigue4.40389759
6MP0000163_abnormal_cartilage_morphology4.17663293
7MP0009250_abnormal_appendicular_skeleto4.04887217
8MP0009780_abnormal_chondrocyte_physiolo3.49200650
9MP0002115_abnormal_skeleton_extremities3.35731615
10MP0003283_abnormal_digestive_organ3.32581207
11MP0006054_spinal_hemorrhage3.05770887
12MP0002089_abnormal_postnatal_growth/wei3.00522497
13MP0010368_abnormal_lymphatic_system2.88706989
14MP0002113_abnormal_skeleton_development2.86917758
15MP0002896_abnormal_bone_mineralization2.75354050
16MP0005257_abnormal_intraocular_pressure2.71724987
17MP0000762_abnormal_tongue_morphology2.61388810
18MP0003123_paternal_imprinting2.60241193
19MP0002909_abnormal_adrenal_gland2.58608788
20MP0001299_abnormal_eye_distance/2.44031133
21MP0001533_abnormal_skeleton_physiology2.42078032
22MP0005508_abnormal_skeleton_morphology2.41012532
23MP0005390_skeleton_phenotype2.36953578
24MP0005623_abnormal_meninges_morphology2.31252861
25MP0001270_distended_abdomen2.21410770
26MP0002109_abnormal_limb_morphology2.12026400
27MP0000013_abnormal_adipose_tissue2.03849506
28MP0002295_abnormal_pulmonary_circulatio2.00228335
29MP0003656_abnormal_erythrocyte_physiolo1.97007256
30MP0003795_abnormal_bone_structure1.96031890
31MP0001542_abnormal_bone_strength1.88117916
32MP0000751_myopathy1.83790679
33MP0008438_abnormal_cutaneous_collagen1.79245513
34MP0009384_cardiac_valve_regurgitation1.73647778
35MP0003755_abnormal_palate_morphology1.69837918
36MP0000049_abnormal_middle_ear1.68760327
37MP0002116_abnormal_craniofacial_bone1.60980537
38MP0005171_absent_coat_pigmentation1.57759304
39MP0002163_abnormal_gland_morphology1.54739806
40MP0003787_abnormal_imprinting1.52778739
41MP0008004_abnormal_stomach_pH1.51789916
42MP0003195_calcinosis1.50058364
43MP0005595_abnormal_vascular_smooth1.48019308
44MP0010386_abnormal_urinary_bladder1.46111992
45MP0002108_abnormal_muscle_morphology1.38247569
46MP0005275_abnormal_skin_tensile1.36022486
47MP0003436_decreased_susceptibility_to1.29782044
48MP0000534_abnormal_ureter_morphology1.29159041
49MP0000432_abnormal_head_morphology1.28524544
50MP0002111_abnormal_tail_morphology1.27283901
51MP0003279_aneurysm1.24428134
52MP0002233_abnormal_nose_morphology1.24159716
53MP0004858_abnormal_nervous_system1.22860599
54MP0000343_altered_response_to1.21390946
55MP0002998_abnormal_bone_remodeling1.19621649
56MP0009697_abnormal_copulation1.16197807
57MP0005381_digestive/alimentary_phenotyp1.15661083
58MP0002249_abnormal_larynx_morphology1.14582773
59MP0004272_abnormal_basement_membrane1.14110997
60MP0001879_abnormal_lymphatic_vessel1.12424957
61MP0001663_abnormal_digestive_system1.11990754
62MP0002114_abnormal_axial_skeleton1.11281900
63MP0005023_abnormal_wound_healing1.10986102
64MP0003935_abnormal_craniofacial_develop1.03158020
65MP0003937_abnormal_limbs/digits/tail_de1.02514685
66MP0003705_abnormal_hypodermis_morpholog1.02153558
67MP0003566_abnormal_cell_adhesion1.01846464
68MP0004484_altered_response_of0.99816389
69MP0000003_abnormal_adipose_tissue0.97568238
70MP0004197_abnormal_fetal_growth/weight/0.92643210
71MP0000759_abnormal_skeletal_muscle0.91788938
72MP0002168_other_aberrant_phenotype0.89910547
73MP0010352_gastrointestinal_tract_polyps0.86116339
74MP0003091_abnormal_cell_migration0.85406100
75MP0000733_abnormal_muscle_development0.85377464
76MP0000462_abnormal_digestive_system0.82350946
77MP0003385_abnormal_body_wall0.81879030
78MP0002128_abnormal_blood_circulation0.80666454
79MP0005164_abnormal_response_to0.80502025
80MP0001963_abnormal_hearing_physiology0.80151718
81MP0002133_abnormal_respiratory_system0.79982269
82MP0005388_respiratory_system_phenotype0.79982269
83MP0003121_genomic_imprinting0.77771009
84MP0000569_abnormal_digit_pigmentation0.76874638
85MP0004084_abnormal_cardiac_muscle0.76139372
86MP0002932_abnormal_joint_morphology0.75046899
87MP0001958_emphysema0.74559982
88MP0002139_abnormal_hepatobiliary_system0.73650008
89MP0000465_gastrointestinal_hemorrhage0.71180665
90MP0003119_abnormal_digestive_system0.70061202
91MP0005379_endocrine/exocrine_gland_phen0.69513248
92MP0005165_increased_susceptibility_to0.69131816
93MP0010030_abnormal_orbit_morphology0.68952553
94MP0009053_abnormal_anal_canal0.68559652
95MP0003115_abnormal_respiratory_system0.66520947
96MP0003806_abnormal_nucleotide_metabolis0.66357860
97MP0001175_abnormal_lung_morphology0.65816574
98MP0003122_maternal_imprinting0.63043515
99MP0003942_abnormal_urinary_system0.60613370
100MP0001348_abnormal_lacrimal_gland0.59692961
101MP0005360_urolithiasis0.58865009
102MP0001943_abnormal_respiration0.58706471
103MP0002877_abnormal_melanocyte_morpholog0.57224131
104MP0002102_abnormal_ear_morphology0.56313224
105MP0005620_abnormal_muscle_contractility0.56178403
106MP0000427_abnormal_hair_cycle0.55389153
107MP0002254_reproductive_system_inflammat0.54563002
108MP0001614_abnormal_blood_vessel0.54500809
109MP0004883_abnormal_blood_vessel0.53780770
110MP0005197_abnormal_uvea_morphology0.53280205
111MP0005646_abnormal_pituitary_gland0.53156558
112MP0002735_abnormal_chemical_nociception0.53042981
113MP0005166_decreased_susceptibility_to0.52363399
114MP0003828_pulmonary_edema0.51431933
115MP0001177_atelectasis0.50390745
116MP0001286_abnormal_eye_development0.50311458
117MP0000467_abnormal_esophagus_morphology0.48157058
118MP0003045_fibrosis0.48153780
119MP0000538_abnormal_urinary_bladder0.48132955
120MP0002234_abnormal_pharynx_morphology0.47761869
121MP0004233_abnormal_muscle_weight0.47679944
122MP0003191_abnormal_cellular_cholesterol0.47667477
123MP0001243_abnormal_dermal_layer0.45092853
124MP0006138_congestive_heart_failure0.44804309
125MP0005193_abnormal_anterior_eye0.44547500
126MP0001756_abnormal_urination0.44054335
127MP0008775_abnormal_heart_ventricle0.42640689
128MP0000428_abnormal_craniofacial_morphol0.42278437
129MP0005248_abnormal_Harderian_gland0.40261962
130MP0001873_stomach_inflammation0.39069954
131MP0002060_abnormal_skin_morphology0.38766375
132MP0003075_altered_response_to0.34724903
133MP0004036_abnormal_muscle_relaxation0.34109224
134MP0005076_abnormal_cell_differentiation0.33934159
135MP0003448_altered_tumor_morphology0.33762249
136MP0000026_abnormal_inner_ear0.31868346
137MP0003950_abnormal_plasma_membrane0.31318818
138MP0000516_abnormal_urinary_system0.31207057
139MP0005367_renal/urinary_system_phenotyp0.31207057
140MP0000749_muscle_degeneration0.29161301
141MP0000230_abnormal_systemic_arterial0.28857379
142MP0003941_abnormal_skin_development0.27286302
143MP0000767_abnormal_smooth_muscle0.27148887

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)9.62731161
2Irregular epiphyses (HP:0010582)9.41483477
3Vitreoretinal degeneration (HP:0000655)8.10414079
4Protrusio acetabuli (HP:0003179)7.60624458
5Premature rupture of membranes (HP:0001788)7.47974247
6Hypoplastic ischia (HP:0003175)6.48351433
7Cupped ribs (HP:0000887)6.45169146
8Abnormal tarsal ossification (HP:0008369)6.40122689
9Small epiphyses (HP:0010585)6.39930908
10Follicular hyperkeratosis (HP:0007502)6.39424621
11Ankle contracture (HP:0006466)6.19661933
12Abnormality of the ischium (HP:0003174)5.75407070
13Flat capital femoral epiphysis (HP:0003370)5.75235118
14Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.55864263
15Delayed epiphyseal ossification (HP:0002663)5.37243603
16Genu varum (HP:0002970)5.36004214
17Flat acetabular roof (HP:0003180)5.31551804
18Type 1 muscle fiber predominance (HP:0003803)5.19274006
19Aortic aneurysm (HP:0004942)5.07101703
20Metaphyseal cupping (HP:0003021)4.95306121
21Slender build (HP:0001533)4.78014777
22Soft skin (HP:0000977)4.68049185
23Abnormal foot bone ossification (HP:0010675)4.66549320
24Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.65389275
25Abnormality of femoral epiphyses (HP:0006499)4.65389275
26Vascular tortuosity (HP:0004948)4.57192989
27Aortic dissection (HP:0002647)4.45379108
28Abnormality of the vertebral endplates (HP:0005106)4.44123997
29Arthropathy (HP:0003040)4.40797260
30Flattened epiphyses (HP:0003071)4.39173457
31Neonatal short-limb short stature (HP:0008921)4.38522485
32Absent epiphyses (HP:0010577)4.34083873
33Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)4.34083873
34Broad metatarsal (HP:0001783)4.28076951
35Bladder diverticulum (HP:0000015)4.27109851
36Abnormality of the epiphysis of the femoral head (HP:0010574)4.21657820
37Spinal rigidity (HP:0003306)4.17400171
38Metaphyseal dysplasia (HP:0100255)4.08843567
39Mild short stature (HP:0003502)4.08072948
40Short femoral neck (HP:0100864)4.00241670
41Irregular vertebral endplates (HP:0003301)3.94323609
42Abnormality of the femoral head (HP:0003368)3.91265926
43Osteoarthritis (HP:0002758)3.86987411
44Genu recurvatum (HP:0002816)3.83945378
45Wormian bones (HP:0002645)3.73019363
46Metaphyseal irregularity (HP:0003025)3.68205601
47Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.65502194
48Abnormality of dentin (HP:0010299)3.63231443
49Aortic regurgitation (HP:0001659)3.53991264
50Shallow orbits (HP:0000586)3.41305493
51Arterial tortuosity (HP:0005116)3.39608950
52Coxa vara (HP:0002812)3.35446568
53Vertebral compression fractures (HP:0002953)3.35237594
54Bowel diverticulosis (HP:0005222)3.32488310
55Abnormality of the proximal phalanges of the hand (HP:0009834)3.30731613
56Abnormal vertebral ossification (HP:0100569)3.30074192
57Abnormality of carpal bone ossification (HP:0006257)3.29036620
58Spondylolisthesis (HP:0003302)3.26177999
59Protuberant abdomen (HP:0001538)3.25729476
60Hypoventilation (HP:0002791)3.23855776
61Abnormality of the phalanges of the 2nd finger (HP:0009541)3.23412286
62Mildly elevated creatine phosphokinase (HP:0008180)3.19855072
63Abnormality of the pubic bones (HP:0003172)3.17692585
64Enlarged epiphyses (HP:0010580)3.14127958
65Coronal craniosynostosis (HP:0004440)3.13889188
66Aortic valve stenosis (HP:0001650)3.12850171
67Overgrowth (HP:0001548)3.12169017
68Atrophic scars (HP:0001075)3.10021073
69Dilatation of the ascending aorta (HP:0005111)3.09688161
70Thoracolumbar scoliosis (HP:0002944)3.05926706
71Barrel-shaped chest (HP:0001552)3.03966421
72Beaking of vertebral bodies (HP:0004568)3.02544844
73Cervical subluxation (HP:0003308)3.02523361
74Waddling gait (HP:0002515)2.99340235
75Platyspondyly (HP:0000926)2.97250553
76Blue sclerae (HP:0000592)2.93874590
77Wrist flexion contracture (HP:0001239)2.93447641
78Ovoid vertebral bodies (HP:0003300)2.92351832
79Broad ribs (HP:0000885)2.91559025
80Cardiovascular calcification (HP:0011915)2.87976255
81Increased variability in muscle fiber diameter (HP:0003557)2.85369943
82Redundant skin (HP:0001582)2.83708682
83Aplasia/hypoplasia of the femur (HP:0005613)2.83695054
84Mitral stenosis (HP:0001718)2.83187215
85Elbow flexion contracture (HP:0002987)2.80790130
86Limited elbow extension (HP:0001377)2.80369555
87Joint laxity (HP:0001388)2.79569029
88Fragile skin (HP:0001030)2.78849786
89Vertebral clefting (HP:0008428)2.75249811
90Stillbirth (HP:0003826)2.73468242
91Thin ribs (HP:0000883)2.71720845
92Osteolytic defects of the hand bones (HP:0009699)2.68218598
93Osteolytic defects of the phalanges of the hand (HP:0009771)2.68218598
94Biconcave vertebral bodies (HP:0004586)2.67617535
95Absent frontal sinuses (HP:0002688)2.66966469
96Hyperextensible skin (HP:0000974)2.66567530
97Mitral regurgitation (HP:0001653)2.66440716
98Abnormality of incisor morphology (HP:0011063)2.65543536
99Delayed closure of the anterior fontanelle (HP:0001476)2.63763973
100Limited hip movement (HP:0008800)2.61390689
101Abnormal hand bone ossification (HP:0010660)2.60677118
102Peritonitis (HP:0002586)2.60637898
103Exostoses (HP:0100777)2.59868739
104Carpal bone hypoplasia (HP:0001498)2.57357853
105Abnormal ossification of hand bones (HP:0005921)2.53226580
106Lumbar hyperlordosis (HP:0002938)2.52377196
107Flared iliac wings (HP:0002869)2.49257239
108Fibular hypoplasia (HP:0003038)2.47835036
109Glossoptosis (HP:0000162)2.47264888
110Hypoplasia of the odontoid process (HP:0003311)2.43992788
111Abnormality of the lumbar spine (HP:0100712)2.42644229
112Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.41636548
113Hip contracture (HP:0003273)2.41600893
114Abnormality of the vitreous humor (HP:0004327)2.36713059
115Generalized amyotrophy (HP:0003700)2.35931350
116Limb-girdle muscle weakness (HP:0003325)2.34712797
117Spinal cord compression (HP:0002176)2.34224397
118Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.33625457
119Hypoplastic pelvis (HP:0008839)2.31242470
120Mesomelia (HP:0003027)2.30934323
121Mitral valve prolapse (HP:0001634)2.29715505
122Abnormality of the 2nd finger (HP:0004100)2.29513930
123Abnormality of skeletal muscle fiber size (HP:0012084)2.28918918
124Long clavicles (HP:0000890)2.28773615
125Reduced subcutaneous adipose tissue (HP:0003758)2.26911258
126Disproportionate short-trunk short stature (HP:0003521)2.26899018
127Abnormal delivery (HP:0001787)2.23392185
128Vertebral hypoplasia (HP:0008417)2.23378839
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.23378839
130Flat cornea (HP:0007720)2.19610195
131Persistence of primary teeth (HP:0006335)2.18588640
132Increased connective tissue (HP:0009025)2.17879779
133Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17109077
134Hypoplastic ilia (HP:0000946)2.15800131
135Wide anterior fontanel (HP:0000260)2.14970960
136Relative macrocephaly (HP:0004482)2.14381437
137Micromelia (HP:0002983)2.13614606
138Abnormality of the phalanges of the 5th finger (HP:0004213)2.13133543
139Broad phalanx (HP:0006009)2.11181710
140Short middle phalanx of finger (HP:0005819)2.10694182
141Delayed cranial suture closure (HP:0000270)2.09759328
142Nonimmune hydrops fetalis (HP:0001790)2.08567286
143Round ear (HP:0100830)2.08107180
144Abnormality of the odontoid process (HP:0003310)2.01152290
145Aneurysm (HP:0002617)2.00731231
146Camptodactyly of toe (HP:0001836)2.00208815
147Abnormality of the acetabulum (HP:0003170)1.99968524
148Renal duplication (HP:0000075)1.97079466
149Broad long bones (HP:0005622)1.97073976
150Hallux valgus (HP:0001822)1.96475053
151Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.95068875
152Pulmonary artery stenosis (HP:0004415)1.93637380
153Deviation of the hallux (HP:0010051)1.93634198
154Entropion (HP:0000621)1.92950162
155Delayed gross motor development (HP:0002194)1.91788647
156Protruding ear (HP:0000411)1.91738274
157Radial bowing (HP:0002986)1.90956245
158Narrow nasal bridge (HP:0000446)1.90799064
159Long toe (HP:0010511)1.90053914
160Femoral bowing (HP:0002980)1.87054554
161Natal tooth (HP:0000695)1.86828018
162Flared metaphyses (HP:0003015)1.86296064
163Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86278866
164Cerebral aneurysm (HP:0004944)1.86203414
165Mixed hearing impairment (HP:0000410)1.84131005
166Abnormality of skull ossification (HP:0002703)1.83961087
167Hypoplasia of the capital femoral epiphysis (HP:0003090)1.83733838
168Abnormality of the frontal sinuses (HP:0002687)1.82264399
169Coxa valga (HP:0002673)1.80154963
170Short ribs (HP:0000773)1.79256584
171Joint stiffness (HP:0001387)1.78489803
172Inguinal hernia (HP:0000023)1.77882276
173Genu valgum (HP:0002857)1.77248853
174Upper limb amyotrophy (HP:0009129)1.76374707
175Distal upper limb amyotrophy (HP:0007149)1.76374707
176Broad thumb (HP:0011304)1.76229418
177Patent foramen ovale (HP:0001655)1.75092319
178Rhizomelia (HP:0008905)1.75004291
179Ectopia lentis (HP:0001083)1.74517488
180Decreased skull ossification (HP:0004331)1.73179560
181Breech presentation (HP:0001623)1.72952538
182Vascular calcification (HP:0004934)1.70698916
183Disproportionate tall stature (HP:0001519)1.69895469
184Tibial bowing (HP:0002982)1.66788009
185Gingival overgrowth (HP:0000212)1.65438615
186Hypoplasia of the iris (HP:0007676)1.65359362

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.42479150
2MAP3K36.84179355
3STK38L5.43794983
4STK245.26280868
5MYLK4.56798472
6NEK94.49492555
7PRKG24.14439375
8NME13.98710499
9TGFBR23.34114002
10PDGFRA3.31394039
11MST42.84057985
12MOS2.56249560
13PAK22.39870762
14PRKD32.35786888
15LATS12.32563158
16PAK62.24620498
17NUAK12.24488025
18ERBB32.04500382
19PLK21.88447415
20PAK41.82203943
21AKT31.72256792
22STK31.72198540
23TTN1.63281356
24PIK3CG1.56618708
25DYRK1A1.53912137
26STK381.53791180
27PIM21.52733898
28FRK1.47317141
29ABL21.46524460
30PAK31.44900458
31MKNK21.38310661
32KIT1.32438328
33TAOK11.19897158
34GRK71.17452547
35ADRBK21.16470431
36NEK61.16104955
37CDC42BPA1.15524459
38ILK1.13988300
39EIF2AK31.11339472
40TRPM71.11259888
41NTRK11.06004508
42DMPK1.04674401
43MET1.03209207
44PBK1.03186276
45MAPK121.02871374
46GRK11.02216921
47ROCK10.96518558
48ERBB40.90334629
49MAPK70.89813260
50EPHB20.88248744
51BRSK20.83581095
52SIK10.79646115
53NME20.77511892
54GSK3A0.77425818
55MKNK10.75947206
56MAPK40.72187947
57MELK0.72137220
58STK390.71345458
59MAP3K110.70148345
60WNK40.68824247
61EPHB10.68636896
62BCR0.68621996
63CAMKK20.68363515
64EPHA20.67744045
65MAP2K10.65938619
66MAP3K60.65672844
67MUSK0.65168548
68FGFR30.63350390
69MARK10.63163446
70RIPK10.62796875
71DAPK30.61460864
72PIK3CA0.61222215
73MAP2K30.61107989
74PAK10.59855322
75MAP4K20.59593211
76EIF2AK10.58138703
77DYRK30.52768948
78PDK20.51849704
79PRKD10.50688089
80PLK30.50521700
81GRK50.49661674
82JAK10.46274194
83TRIB30.46229987
84MAPKAPK30.43513739
85LIMK10.41647025
86PRKG10.40004852
87TGFBR10.39688846
88PKN20.39600246
89PIM10.38897992
90RAF10.36715067
91LMTK20.36179399
92MAP3K120.36066941
93MAPK110.35191232
94PRKCH0.34849645
95CAMK2G0.34822444
96TAOK20.34338870
97PRKACG0.33500494
98ERN10.31118370
99LATS20.30791062
100PKN10.30588529
101SIK30.30389666
102BMPR20.29712503
103FGFR10.29538923
104RPS6KB10.27887765
105STK160.27736192
106EPHA40.27092722
107PRKCG0.26575135
108PRKCD0.26092391
109PTK2B0.25880576
110PINK10.25724875
111ABL10.25356899
112CAMK2A0.25109586
113DYRK1B0.24960862
114EPHA30.24472480
115CAMK2B0.22724464
116MAP3K50.22188456
117CAMK10.21409651
118TIE10.21012736
119MAPK100.20828810
120CSNK1A1L0.20816105
121KSR10.20317350
122MST1R0.19541147
123MAPKAPK20.19060674
124MAP3K40.18826647
125CAMK2D0.18463666
126NLK0.18221476
127MARK30.17918412
128SGK10.17683007
129PRKCI0.17480807
130IKBKB0.16892964
131MAPK30.16556267
132PRKD20.15011748
133SGK20.14898971
134PRKACA0.13896982
135MAPK10.13793343
136IGF1R0.13222848
137PRKCE0.12999871
138ADRBK10.11583123
139SGK30.11279229
140CAMKK10.11062302
141TEC0.10563465
142ROCK20.09658935
143PRKCA0.09072271
144PTK20.08787971
145TESK10.08775514
146WNK10.08577733
147EIF2AK20.08566945
148CSNK1G10.08484543
149PDGFRB0.08463492
150FLT30.08417534
151INSR0.08292518

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005327.96112059
2ECM-receptor interaction_Homo sapiens_hsa045126.36465097
3Protein digestion and absorption_Homo sapiens_hsa049745.92154774
4Sphingolipid metabolism_Homo sapiens_hsa006002.98349449
5Sulfur metabolism_Homo sapiens_hsa009202.71293269
6Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.53560830
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.47501623
8Steroid biosynthesis_Homo sapiens_hsa001002.43535046
9Focal adhesion_Homo sapiens_hsa045102.32298582
10Olfactory transduction_Homo sapiens_hsa047402.07834080
11Melanoma_Homo sapiens_hsa052182.04882963
12Protein export_Homo sapiens_hsa030601.89279549
13Malaria_Homo sapiens_hsa051441.79930085
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.72691586
15Starch and sucrose metabolism_Homo sapiens_hsa005001.71764160
16PI3K-Akt signaling pathway_Homo sapiens_hsa041511.71677211
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.70375515
18TGF-beta signaling pathway_Homo sapiens_hsa043501.61043962
19Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59738318
20Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.57082956
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.44804154
22Other glycan degradation_Homo sapiens_hsa005111.33991354
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.26870317
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24004389
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22431814
26MicroRNAs in cancer_Homo sapiens_hsa052061.21741911
27Ovarian steroidogenesis_Homo sapiens_hsa049131.17865601
28Selenocompound metabolism_Homo sapiens_hsa004501.17471758
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14455594
30Dorso-ventral axis formation_Homo sapiens_hsa043201.09099480
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08756117
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.08036416
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.07747557
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.06578235
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05386526
36Axon guidance_Homo sapiens_hsa043601.02838777
37Hedgehog signaling pathway_Homo sapiens_hsa043400.98833046
38Arginine and proline metabolism_Homo sapiens_hsa003300.98629984
39Proteoglycans in cancer_Homo sapiens_hsa052050.98583037
40Vascular smooth muscle contraction_Homo sapiens_hsa042700.98500586
41Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95711358
42Ras signaling pathway_Homo sapiens_hsa040140.95535744
43Hippo signaling pathway_Homo sapiens_hsa043900.95308867
44Pathways in cancer_Homo sapiens_hsa052000.91855018
45Lysosome_Homo sapiens_hsa041420.88533415
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.80215964
47Basal cell carcinoma_Homo sapiens_hsa052170.80179561
48Small cell lung cancer_Homo sapiens_hsa052220.79562603
49Phospholipase D signaling pathway_Homo sapiens_hsa040720.77028694
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76728483
51p53 signaling pathway_Homo sapiens_hsa041150.76588299
52Shigellosis_Homo sapiens_hsa051310.72157839
53Calcium signaling pathway_Homo sapiens_hsa040200.70212232
54Long-term depression_Homo sapiens_hsa047300.70152442
55Folate biosynthesis_Homo sapiens_hsa007900.67624411
56Salivary secretion_Homo sapiens_hsa049700.66585914
57Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65930843
58Phagosome_Homo sapiens_hsa041450.65780267
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64359287
60Insulin secretion_Homo sapiens_hsa049110.63881138
61Arachidonic acid metabolism_Homo sapiens_hsa005900.63317138
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62799382
63TNF signaling pathway_Homo sapiens_hsa046680.60632416
64Prostate cancer_Homo sapiens_hsa052150.58270114
65Vibrio cholerae infection_Homo sapiens_hsa051100.57067853
66Renin-angiotensin system_Homo sapiens_hsa046140.56586185
67MAPK signaling pathway_Homo sapiens_hsa040100.56502505
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.55917848
69Galactose metabolism_Homo sapiens_hsa000520.55389054
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54599921
71Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54503793
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.51180147
73Circadian entrainment_Homo sapiens_hsa047130.50498979
74Endocytosis_Homo sapiens_hsa041440.50345085
75Thyroid hormone synthesis_Homo sapiens_hsa049180.48317466
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48030823
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46056930
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45819223
79N-Glycan biosynthesis_Homo sapiens_hsa005100.45074522
80Vitamin B6 metabolism_Homo sapiens_hsa007500.44031058
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43951742
82Gap junction_Homo sapiens_hsa045400.43891500
83Complement and coagulation cascades_Homo sapiens_hsa046100.43779032
84Dilated cardiomyopathy_Homo sapiens_hsa054140.43612580
85One carbon pool by folate_Homo sapiens_hsa006700.43345323
86Glioma_Homo sapiens_hsa052140.42445804
87Pertussis_Homo sapiens_hsa051330.42342118
88Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42034254
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41659702
90GnRH signaling pathway_Homo sapiens_hsa049120.40826247
91Circadian rhythm_Homo sapiens_hsa047100.40732328
92Wnt signaling pathway_Homo sapiens_hsa043100.40016582
93Glutamatergic synapse_Homo sapiens_hsa047240.35809434
94mTOR signaling pathway_Homo sapiens_hsa041500.34611151
95Estrogen signaling pathway_Homo sapiens_hsa049150.33983995
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33323384
97Melanogenesis_Homo sapiens_hsa049160.32713902
98Lysine degradation_Homo sapiens_hsa003100.32440542
99GABAergic synapse_Homo sapiens_hsa047270.32061482
100HIF-1 signaling pathway_Homo sapiens_hsa040660.31943931
101Vitamin digestion and absorption_Homo sapiens_hsa049770.31437972
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31365907
103Nitrogen metabolism_Homo sapiens_hsa009100.30800468
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30269557
105Oxytocin signaling pathway_Homo sapiens_hsa049210.30114495
106Tight junction_Homo sapiens_hsa045300.28864774
107Bladder cancer_Homo sapiens_hsa052190.27531779
108Gastric acid secretion_Homo sapiens_hsa049710.25715827
109Bile secretion_Homo sapiens_hsa049760.25484715
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24243414
111Arginine biosynthesis_Homo sapiens_hsa002200.23049400
112Platelet activation_Homo sapiens_hsa046110.22500227
113Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.20430582
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.20181427
115Renin secretion_Homo sapiens_hsa049240.19843309
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18640863
117cAMP signaling pathway_Homo sapiens_hsa040240.18343563
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.18168371
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16865798
120Legionellosis_Homo sapiens_hsa051340.16667994
121Mineral absorption_Homo sapiens_hsa049780.15363409
122Neurotrophin signaling pathway_Homo sapiens_hsa047220.14381125
123ErbB signaling pathway_Homo sapiens_hsa040120.14038715
124Thyroid cancer_Homo sapiens_hsa052160.13168750
125Insulin resistance_Homo sapiens_hsa049310.12227885
126Amphetamine addiction_Homo sapiens_hsa050310.12088928
127Glutathione metabolism_Homo sapiens_hsa004800.11767068
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11447388
129Sphingolipid signaling pathway_Homo sapiens_hsa040710.11103987
130Metabolic pathways_Homo sapiens_hsa011000.10880195
131Adherens junction_Homo sapiens_hsa045200.10851113
132Chemical carcinogenesis_Homo sapiens_hsa052040.10444496
133Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.10267415
134Amoebiasis_Homo sapiens_hsa051460.09205906
135HTLV-I infection_Homo sapiens_hsa051660.07976810
136Cocaine addiction_Homo sapiens_hsa050300.07784213
137Cholinergic synapse_Homo sapiens_hsa047250.07459428
138Rap1 signaling pathway_Homo sapiens_hsa040150.07406058
139Renal cell carcinoma_Homo sapiens_hsa052110.07368876
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.05941055

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