ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	tachykinin receptor signaling pathway (GO:0007217)	9.32988776
2	positive regulation of digestive system process (GO:0060456)	6.20344308
3	L-fucose catabolic process (GO:0042355)	5.18405691
4	fucose catabolic process (GO:0019317)	5.18405691
5	L-fucose metabolic process (GO:0042354)	5.18405691
6	behavioral response to nicotine (GO:0035095)	5.03741388
7	detection of light stimulus involved in visual perception (GO:0050908)	4.42682078
8	detection of light stimulus involved in sensory perception (GO:0050962)	4.42682078
9	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	4.36526955
10	adaptation of signaling pathway (GO:0023058)	4.27200163
11	auditory receptor cell stereocilium organization (GO:0060088)	3.90020243
12	cochlea development (GO:0090102)	3.89194933
13	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.77919359
14	NAD biosynthetic process (GO:0009435)	3.77450127
15	regulation of germinal center formation (GO:0002634)	3.72849650
16	DNA deamination (GO:0045006)	3.69425550
17	gamma-aminobutyric acid signaling pathway (GO:0007214)	3.68740733
18	response to histamine (GO:0034776)	3.53861090
19	response to pheromone (GO:0019236)	3.49830134
20	DNA double-strand break processing (GO:0000729)	3.46072427
21	flavonoid metabolic process (GO:0009812)	3.37574685
22	negative regulation of mast cell activation (GO:0033004)	3.29314654
23	multicellular organism reproduction (GO:0032504)	3.28472422
24	positive regulation of interferon-gamma biosynthetic process (GO:0045078)	3.26475362
25	sulfation (GO:0051923)	3.19211286
26	tryptophan catabolic process (GO:0006569)	3.17430578
27	indole-containing compound catabolic process (GO:0042436)	3.17430578
28	indolalkylamine catabolic process (GO:0046218)	3.17430578
29	aggressive behavior (GO:0002118)	3.14921828
30	detection of mechanical stimulus involved in sensory perception (GO:0050974)	3.13442921
31	mesenchymal cell differentiation involved in renal system development (GO:2001012)	3.12350437
32	mesenchymal cell differentiation involved in kidney development (GO:0072161)	3.12350437
33	reflex (GO:0060004)	3.09099281
34	negative regulation of systemic arterial blood pressure (GO:0003085)	3.09070169
35	adrenergic receptor signaling pathway (GO:0071875)	3.09018598
36	water-soluble vitamin biosynthetic process (GO:0042364)	3.08573116
37	inner ear receptor cell development (GO:0060119)	3.05884154
38	piRNA metabolic process (GO:0034587)	3.05061402
39	rRNA catabolic process (GO:0016075)	3.01612995
40	regulation of cilium movement (GO:0003352)	3.01306393
41	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.00351384
42	cell differentiation involved in metanephros development (GO:0072202)	2.99447494
43	pyridine nucleotide biosynthetic process (GO:0019363)	2.98119710
44	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.98119710
45	regulation of action potential (GO:0098900)	2.96137903
46	kynurenine metabolic process (GO:0070189)	2.95703841
47	indolalkylamine metabolic process (GO:0006586)	2.95514710
48	inner ear receptor stereocilium organization (GO:0060122)	2.94718291
49	rhodopsin mediated signaling pathway (GO:0016056)	2.88831180
50	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.88220640
51	replication fork processing (GO:0031297)	2.87181220
52	innervation (GO:0060384)	2.86276034
53	L-methionine salvage (GO:0071267)	2.82226618
54	L-methionine biosynthetic process (GO:0071265)	2.82226618
55	amino acid salvage (GO:0043102)	2.82226618
56	tryptophan metabolic process (GO:0006568)	2.80050083
57	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.78487752
58	transepithelial transport (GO:0070633)	2.78057008
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75020552
60	regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003339	2.69695248
61	gamma-aminobutyric acid transport (GO:0015812)	2.66405361
62	positive regulation of guanylate cyclase activity (GO:0031284)	2.66254978
63	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.64502297
64	postsynaptic membrane organization (GO:0001941)	2.63379913
65	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.61566805
66	righting reflex (GO:0060013)	2.61451020
67	negative regulation of multicellular organism growth (GO:0040015)	2.58626620
68	double-strand break repair via homologous recombination (GO:0000724)	2.58132043
69	recombinational repair (GO:0000725)	2.57099494
70	synaptic transmission, cholinergic (GO:0007271)	2.55558466
71	regulation of timing of cell differentiation (GO:0048505)	2.55029443
72	behavioral response to ethanol (GO:0048149)	2.53964605
73	retinal cone cell development (GO:0046549)	2.53960596
74	protein polyglutamylation (GO:0018095)	2.52018273
75	sperm motility (GO:0030317)	2.51066202
76	negative regulation of astrocyte differentiation (GO:0048712)	2.50444785
77	cornea development in camera-type eye (GO:0061303)	2.50403859
78	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.49676133
79	negative regulation by host of viral transcription (GO:0043922)	2.48937035
80	neural tube formation (GO:0001841)	2.48384800
81	positive regulation of glomerulus development (GO:0090193)	2.47447480
82	cAMP catabolic process (GO:0006198)	2.47052062
83	ADP metabolic process (GO:0046031)	2.46422999
84	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.44674989
85	negative regulation of telomere maintenance (GO:0032205)	2.44105951
86	pseudouridine synthesis (GO:0001522)	2.43395464
87	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.42969135
88	photoreceptor cell maintenance (GO:0045494)	2.42878597
89	fucosylation (GO:0036065)	2.42679529
90	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.39509389
91	cellular response to exogenous dsRNA (GO:0071360)	2.38121981
92	DNA methylation involved in gamete generation (GO:0043046)	2.38004431
93	cellular ketone body metabolic process (GO:0046950)	2.36681912
94	protein K11-linked deubiquitination (GO:0035871)	2.36020104
95	indole-containing compound metabolic process (GO:0042430)	2.35655000
96	protein localization to cilium (GO:0061512)	2.35633802
97	proline transport (GO:0015824)	2.35562540
98	photoreceptor cell development (GO:0042461)	2.34878307
99	regulation of interferon-gamma biosynthetic process (GO:0045072)	2.33253378
100	regulation of digestive system process (GO:0044058)	2.31798932

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.64769527
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.64025832
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38827911
4	GBX2_23144817_ChIP-Seq_PC3_Human	3.20261329
5	VDR_22108803_ChIP-Seq_LS180_Human	3.12532564
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.06864735
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.82110478
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.65332732
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.32120113
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.31623032
11	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.30685852
12	BCAT_22108803_ChIP-Seq_LS180_Human	2.26416866
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.26173561
14	TAF15_26573619_Chip-Seq_HEK293_Human	2.18578052
15	P300_19829295_ChIP-Seq_ESCs_Human	2.16802981
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11827823
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.00832682
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97046963
19	FUS_26573619_Chip-Seq_HEK293_Human	1.96852753
20	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.88368647
21	EWS_26573619_Chip-Seq_HEK293_Human	1.84833946
22	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.83470355
23	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.79520849
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.76781268
25	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73174458
26	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.72424376
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.71061956
28	STAT3_23295773_ChIP-Seq_U87_Human	1.68174352
29	CBP_20019798_ChIP-Seq_JUKART_Human	1.64036857
30	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.64036857
31	TCF4_23295773_ChIP-Seq_U87_Human	1.62776608
32	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.60573875
33	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60242081
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.55550154
35	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54626279
36	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.52786499
37	TCF4_22108803_ChIP-Seq_LS180_Human	1.51630199
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49211947
39	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.47775073
40	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.47239853
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.47239853
42	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.45685969
43	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.44234877
44	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.43811793
45	AR_25329375_ChIP-Seq_VCAP_Human	1.42574239
46	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37293632
47	TP53_22573176_ChIP-Seq_HFKS_Human	1.36836918
48	NANOG_19829295_ChIP-Seq_ESCs_Human	1.36576212
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.36576212
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.33329092
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.31838461
52	REST_21632747_ChIP-Seq_MESCs_Mouse	1.30435030
53	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.28090005
54	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.26670759
55	RUNX2_22187159_ChIP-Seq_PCA_Human	1.26307375
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24818710
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.24575480
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23479805
59	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.22831624
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22267634
61	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.21493378
62	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.21403213
63	IRF1_19129219_ChIP-ChIP_H3396_Human	1.21165282
64	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19996716
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.19746336
66	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.18761427
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.18522407
68	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.18487772
69	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16960407
70	CDX2_22108803_ChIP-Seq_LS180_Human	1.15778533
71	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15054513
72	AR_21572438_ChIP-Seq_LNCaP_Human	1.14647867
73	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13629561
74	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13629561
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.12681833
76	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11885258
77	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11056156
78	AR_20517297_ChIP-Seq_VCAP_Human	1.10098414
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09907786
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.08005507
81	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.06283883
82	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.05966975
83	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.05887545
84	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.05465830
85	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.04966281
86	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.03793656
87	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.03333172
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.03056947
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.02234271
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.01615041
91	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.01576209
92	P53_22387025_ChIP-Seq_ESCs_Mouse	1.01264327
93	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.00508440
94	HOXB7_26014856_ChIP-Seq_BT474_Human	0.99795296
95	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99249594
96	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.98824345
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97893353
98	KDM2B_26808549_Chip-Seq_REH_Human	0.96302302
99	NCOR_22424771_ChIP-Seq_293T_Human	0.96151193
100	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.95172670

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	4.30160790
2	MP0001501_abnormal_sleep_pattern	3.27989401
3	MP0000372_irregular_coat_pigmentation	3.22552894
4	MP0003646_muscle_fatigue	3.03083906
5	MP0005551_abnormal_eye_electrophysiolog	2.88010344
6	MP0001968_abnormal_touch/_nociception	2.77412916
7	MP0008872_abnormal_physiological_respon	2.75068471
8	MP0002736_abnormal_nociception_after	2.56777464
9	MP0002102_abnormal_ear_morphology	2.41479619
10	MP0000569_abnormal_digit_pigmentation	2.38314417
11	MP0002138_abnormal_hepatobiliary_system	2.25775227
12	MP0005645_abnormal_hypothalamus_physiol	2.16986689
13	MP0008877_abnormal_DNA_methylation	2.11280234
14	MP0005646_abnormal_pituitary_gland	2.01035290
15	MP0004043_abnormal_pH_regulation	1.99375499
16	MP0005253_abnormal_eye_physiology	1.90564019
17	MP0009745_abnormal_behavioral_response	1.85543709
18	MP0001986_abnormal_taste_sensitivity	1.80475934
19	MP0004742_abnormal_vestibular_system	1.80087530
20	MP0002735_abnormal_chemical_nociception	1.78063819
21	MP0002234_abnormal_pharynx_morphology	1.75156820
22	MP0006276_abnormal_autonomic_nervous	1.74801839
23	MP0001486_abnormal_startle_reflex	1.71439386
24	MP0010386_abnormal_urinary_bladder	1.71412898
25	MP0002272_abnormal_nervous_system	1.67236630
26	MP0002876_abnormal_thyroid_physiology	1.63090016
27	MP0004885_abnormal_endolymph	1.60930222
28	MP0009046_muscle_twitch	1.60667535
29	MP0004142_abnormal_muscle_tone	1.56671589
30	MP0006292_abnormal_olfactory_placode	1.55008464
31	MP0009697_abnormal_copulation	1.44863941
32	MP0000427_abnormal_hair_cycle	1.42468383
33	MP0008875_abnormal_xenobiotic_pharmacok	1.41839352
34	MP0003718_maternal_effect	1.37454717
35	MP0002733_abnormal_thermal_nociception	1.36768638
36	MP0006072_abnormal_retinal_apoptosis	1.33818406
37	MP0001485_abnormal_pinna_reflex	1.33417866
38	MP0001984_abnormal_olfaction	1.31857476
39	MP0002572_abnormal_emotion/affect_behav	1.29537930
40	MP0002638_abnormal_pupillary_reflex	1.26543367
41	MP0002184_abnormal_innervation	1.23985984
42	MP0001970_abnormal_pain_threshold	1.22610067
43	MP0003635_abnormal_synaptic_transmissio	1.18640117
44	MP0005084_abnormal_gallbladder_morpholo	1.16911121
45	MP0003880_abnormal_central_pattern	1.16544537
46	MP0005167_abnormal_blood-brain_barrier	1.15931209
47	MP0003136_yellow_coat_color	1.14807217
48	MP0004215_abnormal_myocardial_fiber	1.14797020
49	MP0005410_abnormal_fertilization	1.13845815
50	MP0005671_abnormal_response_to	1.12323355
51	MP0000631_abnormal_neuroendocrine_gland	1.12313744
52	MP0001440_abnormal_grooming_behavior	1.12113715
53	MP0008775_abnormal_heart_ventricle	1.10666368
54	MP0001963_abnormal_hearing_physiology	1.08633599
55	MP0004484_altered_response_of	1.08351515
56	MP0002751_abnormal_autonomic_nervous	1.08132668
57	MP0000383_abnormal_hair_follicle	1.07798919
58	MP0002067_abnormal_sensory_capabilities	1.07614663
59	MP0001324_abnormal_eye_pigmentation	1.06809161
60	MP0000026_abnormal_inner_ear	1.06296680
61	MP0004145_abnormal_muscle_electrophysio	1.06244259
62	MP0003943_abnormal_hepatobiliary_system	1.04982705
63	MP0005075_abnormal_melanosome_morpholog	1.02008583
64	MP0002653_abnormal_ependyma_morphology	1.00465281
65	MP0002837_dystrophic_cardiac_calcinosis	0.98075941
66	MP0001764_abnormal_homeostasis	0.98056818
67	MP0001835_abnormal_antigen_presentation	0.97831500
68	MP0000230_abnormal_systemic_arterial	0.91828274
69	MP0002064_seizures	0.90983230
70	MP0001905_abnormal_dopamine_level	0.89897727
71	MP0003950_abnormal_plasma_membrane	0.89800049
72	MP0002557_abnormal_social/conspecific_i	0.88875991
73	MP0002752_abnormal_somatic_nervous	0.87102220
74	MP0001873_stomach_inflammation	0.87005432
75	MP0005195_abnormal_posterior_eye	0.85144414
76	MP0008057_abnormal_DNA_replication	0.84710848
77	MP0005377_hearing/vestibular/ear_phenot	0.84505451
78	MP0003878_abnormal_ear_physiology	0.84505451
79	MP0002229_neurodegeneration	0.84472118
80	MP0005647_abnormal_sex_gland	0.82428690
81	MP0005395_other_phenotype	0.82032059
82	MP0002168_other_aberrant_phenotype	0.81779472
83	MP0003787_abnormal_imprinting	0.79983980
84	MP0000778_abnormal_nervous_system	0.78356240
85	MP0004084_abnormal_cardiac_muscle	0.78154235
86	MP0005423_abnormal_somatic_nervous	0.77992521
87	MP0002063_abnormal_learning/memory/cond	0.75359514
88	MP0002734_abnormal_mechanical_nocicepti	0.74305386
89	MP0003698_abnormal_male_reproductive	0.74027514
90	MP0005379_endocrine/exocrine_gland_phen	0.73652302
91	MP0005332_abnormal_amino_acid	0.73166972
92	MP0004085_abnormal_heartbeat	0.72620672
93	MP0005174_abnormal_tail_pigmentation	0.71939597
94	MP0005391_vision/eye_phenotype	0.70975816
95	MP0005386_behavior/neurological_phenoty	0.70165180
96	MP0004924_abnormal_behavior	0.70165180
97	MP0002163_abnormal_gland_morphology	0.69761961
98	MP0003252_abnormal_bile_duct	0.69053035
99	MP0010329_abnormal_lipoprotein_level	0.68914339
100	MP0002938_white_spotting	0.68641079

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of macular pigmentation (HP:0008002)	4.58229541
2	Decreased central vision (HP:0007663)	4.48326938
3	Attenuation of retinal blood vessels (HP:0007843)	4.05701393
4	Pancreatic cysts (HP:0001737)	3.96487350
5	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.60416743
6	True hermaphroditism (HP:0010459)	3.59836432
7	Nephronophthisis (HP:0000090)	3.57859124
8	Progressive inability to walk (HP:0002505)	3.55775501
9	Congenital stationary night blindness (HP:0007642)	3.49820531
10	Abnormality of midbrain morphology (HP:0002418)	3.38009870
11	Molar tooth sign on MRI (HP:0002419)	3.38009870
12	Pancreatic fibrosis (HP:0100732)	3.25417870
13	Abolished electroretinogram (ERG) (HP:0000550)	3.23844141
14	Abnormality of the renal medulla (HP:0100957)	3.12540960
15	Abnormality of the renal cortex (HP:0011035)	3.05587431
16	Chorioretinal atrophy (HP:0000533)	3.04262043
17	Macular degeneration (HP:0000608)	2.86557700
18	Inability to walk (HP:0002540)	2.82041292
19	Decreased circulating renin level (HP:0003351)	2.74898186
20	Dyschromatopsia (HP:0007641)	2.62904907
21	Abnormal drinking behavior (HP:0030082)	2.59984485
22	Polydipsia (HP:0001959)	2.59984485
23	Increased corneal curvature (HP:0100692)	2.58627684
24	Keratoconus (HP:0000563)	2.58627684
25	Type II lissencephaly (HP:0007260)	2.56440053
26	Pendular nystagmus (HP:0012043)	2.56416115
27	Medial flaring of the eyebrow (HP:0010747)	2.55304400
28	Abnormality of alanine metabolism (HP:0010916)	2.54544966
29	Hyperalaninemia (HP:0003348)	2.54544966
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.54544966
31	Hypoplasia of the fovea (HP:0007750)	2.53582390
32	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.53582390
33	Gaze-evoked nystagmus (HP:0000640)	2.43178226
34	Chronic hepatic failure (HP:0100626)	2.40427419
35	IgG deficiency (HP:0004315)	2.39121734
36	Progressive cerebellar ataxia (HP:0002073)	2.36902886
37	Stomach cancer (HP:0012126)	2.36781952
38	Hyperventilation (HP:0002883)	2.36292544
39	Type 2 muscle fiber atrophy (HP:0003554)	2.32123512
40	Renal cortical cysts (HP:0000803)	2.29221533
41	Abnormal rod and cone electroretinograms (HP:0008323)	2.29127736
42	Poikiloderma (HP:0001029)	2.27985472
43	Cystic liver disease (HP:0006706)	2.27414190
44	Abnormality of the fovea (HP:0000493)	2.26831090
45	Constricted visual fields (HP:0001133)	2.26116577
46	Febrile seizures (HP:0002373)	2.25700460
47	Polyuria (HP:0000103)	2.22096634
48	Prostate neoplasm (HP:0100787)	2.20215035
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.19792829
50	Tubular atrophy (HP:0000092)	2.16772367
51	Fibular aplasia (HP:0002990)	2.15413362
52	Bony spicule pigmentary retinopathy (HP:0007737)	2.12532338
53	Methylmalonic acidemia (HP:0002912)	2.06458386
54	Congenital hepatic fibrosis (HP:0002612)	2.04792202
55	Sclerocornea (HP:0000647)	2.04765307
56	Hypophosphatemic rickets (HP:0004912)	2.04762500
57	Thyroiditis (HP:0100646)	2.04687397
58	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.00881543
59	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.99929815
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98190021
61	Absent/shortened dynein arms (HP:0200106)	1.98190021
62	Genetic anticipation (HP:0003743)	1.97240890
63	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.96411947
64	Abnormality of the labia minora (HP:0012880)	1.94378688
65	Cerebellar dysplasia (HP:0007033)	1.94194249
66	Disproportionate short-trunk short stature (HP:0003521)	1.91709079
67	Absent speech (HP:0001344)	1.90758736
68	Genital tract atresia (HP:0001827)	1.90054423
69	Vaginal atresia (HP:0000148)	1.89069347
70	Small hand (HP:0200055)	1.89066997
71	Gait imbalance (HP:0002141)	1.88536885
72	Lissencephaly (HP:0001339)	1.88028513
73	Nephrogenic diabetes insipidus (HP:0009806)	1.86503655
74	Broad-based gait (HP:0002136)	1.85908563
75	Congenital primary aphakia (HP:0007707)	1.85879021
76	Concave nail (HP:0001598)	1.85392287
77	Hypomagnesemia (HP:0002917)	1.85091185
78	Fair hair (HP:0002286)	1.84751854
79	Potter facies (HP:0002009)	1.82608428
80	Facial shape deformation (HP:0011334)	1.82608428
81	Widely spaced teeth (HP:0000687)	1.81743563
82	Abnormality of B cell number (HP:0010975)	1.78863111
83	Ketosis (HP:0001946)	1.78752834
84	Partial agenesis of the corpus callosum (HP:0001338)	1.77498865
85	Abnormality of the prostate (HP:0008775)	1.77024651
86	Methylmalonic aciduria (HP:0012120)	1.76162716
87	Anhidrosis (HP:0000970)	1.76109044
88	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.75373254
89	Hyperglycinuria (HP:0003108)	1.75079317
90	Abnormal urine output (HP:0012590)	1.74837788
91	Focal motor seizures (HP:0011153)	1.74317270
92	Severe muscular hypotonia (HP:0006829)	1.74160117
93	Focal seizures (HP:0007359)	1.72843068
94	Tubulointerstitial abnormality (HP:0001969)	1.72746493
95	Postaxial foot polydactyly (HP:0001830)	1.72556318
96	Stomatitis (HP:0010280)	1.72451033
97	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72039916
98	Pachygyria (HP:0001302)	1.70893539
99	Hypokalemic alkalosis (HP:0001949)	1.70592990
100	Tubulointerstitial nephritis (HP:0001970)	1.69900863

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.36668841
2	MAP4K2	4.16132966
3	ZAK	2.92561991
4	ADRBK2	2.82050345
5	PINK1	2.71006165
6	BMPR1B	2.62744282
7	NUAK1	2.42574202
8	WNK3	2.17158972
9	GRK1	2.12285586
10	MAP3K4	2.01173405
11	TAOK3	1.99326814
12	NEK6	1.93748396
13	TRIM28	1.92390685
14	MAPK13	1.91401130
15	KIT	1.61334643
16	TLK1	1.59143074
17	WNK4	1.51356750
18	INSRR	1.46264483
19	TNIK	1.42965857
20	TIE1	1.40165740
21	TAF1	1.39643043
22	CSNK1A1L	1.36189820
23	TXK	1.31400240
24	STK39	1.30489289
25	ACVR1B	1.29240080
26	MAP2K7	1.28378009
27	BRSK2	1.14628686
28	OXSR1	1.13888261
29	NEK1	1.13208855
30	PRKCE	1.07535531
31	BCR	1.03300114
32	CSNK1G2	1.02043616
33	NEK2	0.98985837
34	DAPK2	0.98307906
35	VRK2	0.96948782
36	PDK2	0.96075194
37	PLK2	0.94425816
38	PLK4	0.90806063
39	ADRBK1	0.90783710
40	TEC	0.90587758
41	MKNK2	0.90433051
42	SIK2	0.89232462
43	PAK3	0.88662373
44	ERBB3	0.86808517
45	EIF2AK3	0.84503008
46	MATK	0.82987280
47	VRK1	0.82308005
48	PHKG1	0.82303297
49	PHKG2	0.82303297
50	TGFBR1	0.81325423
51	CSNK1G3	0.81302907
52	CSNK1G1	0.78439250
53	STK38L	0.77941295
54	CAMKK2	0.76875442
55	CASK	0.73450448
56	AKT3	0.72824606
57	DYRK2	0.71231352
58	SRPK1	0.71076043
59	PKN1	0.70954047
60	ICK	0.70870765
61	SIK3	0.69641209
62	PRKCG	0.66156772
63	WNK1	0.66152102
64	IKBKB	0.64698665
65	TNK2	0.64574090
66	MAPKAPK5	0.61763216
67	MUSK	0.60217512
68	WEE1	0.60105300
69	EPHA4	0.59801260
70	MARK1	0.58735507
71	PIK3CG	0.58717685
72	MAP2K6	0.58063808
73	PRKAA2	0.57091022
74	FES	0.57032518
75	FER	0.54517361
76	PIK3CA	0.54409862
77	PTK2B	0.52776464
78	BRD4	0.52484081
79	MAPKAPK3	0.49701008
80	PLK3	0.46232363
81	MARK3	0.45754040
82	BUB1	0.45611833
83	CAMK4	0.45377539
84	PRKCQ	0.43873359
85	SYK	0.43850710
86	CAMK1	0.43228567
87	BCKDK	0.42436224
88	NLK	0.42114786
89	OBSCN	0.41651637
90	IRAK1	0.41201172
91	EIF2AK2	0.40692511
92	CSNK1A1	0.39446960
93	STK11	0.38360106
94	PRKCA	0.37992706
95	CAMK2A	0.37853458
96	RPS6KA5	0.36852994
97	CSNK1D	0.36680105
98	ATM	0.36107780
99	NTRK3	0.35250906
100	MST4	0.35091598

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.34431662
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.69242271
3	Asthma_Homo sapiens_hsa05310	2.65050924
4	Phototransduction_Homo sapiens_hsa04744	2.64071432
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.31160040
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.29582698
7	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.18288139
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.12591972
9	Morphine addiction_Homo sapiens_hsa05032	2.10349036
10	Nitrogen metabolism_Homo sapiens_hsa00910	1.94067800
11	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.88732158
12	Olfactory transduction_Homo sapiens_hsa04740	1.87379795
13	Ether lipid metabolism_Homo sapiens_hsa00565	1.80652357
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.68039406
15	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.66752471
16	Butanoate metabolism_Homo sapiens_hsa00650	1.66424731
17	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.64422294
18	Caffeine metabolism_Homo sapiens_hsa00232	1.62854017
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.62790074
20	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.61236984
21	GABAergic synapse_Homo sapiens_hsa04727	1.60916505
22	Allograft rejection_Homo sapiens_hsa05330	1.58153814
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.56391687
24	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.53402518
25	Tryptophan metabolism_Homo sapiens_hsa00380	1.52294533
26	RNA degradation_Homo sapiens_hsa03018	1.49504582
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.47152026
28	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.46741645
29	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.44163806
30	Taste transduction_Homo sapiens_hsa04742	1.40653148
31	Glycerolipid metabolism_Homo sapiens_hsa00561	1.40166808
32	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.39334841
33	Homologous recombination_Homo sapiens_hsa03440	1.38469984
34	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.35778474
35	Salivary secretion_Homo sapiens_hsa04970	1.34947283
36	Graft-versus-host disease_Homo sapiens_hsa05332	1.34805052
37	Serotonergic synapse_Homo sapiens_hsa04726	1.32138985
38	Type I diabetes mellitus_Homo sapiens_hsa04940	1.30846657
39	Propanoate metabolism_Homo sapiens_hsa00640	1.27423645
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.23273482
41	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21340143
42	Basal transcription factors_Homo sapiens_hsa03022	1.20176183
43	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.18331094
44	Retinol metabolism_Homo sapiens_hsa00830	1.16981427
45	Regulation of autophagy_Homo sapiens_hsa04140	1.16219090
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.06786698
47	Circadian entrainment_Homo sapiens_hsa04713	1.06132474
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.05084448
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.02843782
50	ABC transporters_Homo sapiens_hsa02010	1.01554176
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.97306512
52	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.96486237
53	RNA polymerase_Homo sapiens_hsa03020	0.95359522
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89720266
55	Insulin secretion_Homo sapiens_hsa04911	0.89276141
56	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.89009143
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.88325380
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.87004275
59	Non-homologous end-joining_Homo sapiens_hsa03450	0.82802898
60	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82626489
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.81985686
62	beta-Alanine metabolism_Homo sapiens_hsa00410	0.74466558
63	Histidine metabolism_Homo sapiens_hsa00340	0.74377726
64	Fat digestion and absorption_Homo sapiens_hsa04975	0.71502875
65	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.68790460
66	Peroxisome_Homo sapiens_hsa04146	0.67219907
67	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.66930255
68	One carbon pool by folate_Homo sapiens_hsa00670	0.65466300
69	Gastric acid secretion_Homo sapiens_hsa04971	0.62838313
70	Dopaminergic synapse_Homo sapiens_hsa04728	0.62106852
71	Antigen processing and presentation_Homo sapiens_hsa04612	0.61907344
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.61673486
73	Amphetamine addiction_Homo sapiens_hsa05031	0.58410481
74	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57071899
75	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.56864141
76	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.56617515
77	Renin secretion_Homo sapiens_hsa04924	0.56543304
78	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.53311658
79	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.50630120
80	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.48966869
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47694000
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.47534956
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.46325766
84	Purine metabolism_Homo sapiens_hsa00230	0.46135234
85	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.45367905
86	Protein export_Homo sapiens_hsa03060	0.43574318
87	Cocaine addiction_Homo sapiens_hsa05030	0.41501960
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40948981
89	Glutathione metabolism_Homo sapiens_hsa00480	0.40782065
90	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.40277261
91	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.38447436
92	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.37779304
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.36663063
94	Metabolic pathways_Homo sapiens_hsa01100	0.35086852
95	Arginine and proline metabolism_Homo sapiens_hsa00330	0.34395038
96	Circadian rhythm_Homo sapiens_hsa04710	0.33916029
97	Long-term depression_Homo sapiens_hsa04730	0.33122518
98	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.33061894
99	Oxidative phosphorylation_Homo sapiens_hsa00190	0.32226296
100	Cholinergic synapse_Homo sapiens_hsa04725	0.31961257

FAM180B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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