FAM181A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.17945435
2fusion of sperm to egg plasma membrane (GO:0007342)9.04180878
3piRNA metabolic process (GO:0034587)9.02734927
4acrosome reaction (GO:0007340)8.74941242
5axonemal dynein complex assembly (GO:0070286)8.39229275
6motile cilium assembly (GO:0044458)7.76502412
7sperm-egg recognition (GO:0035036)7.74133122
8acrosome assembly (GO:0001675)7.67452009
9epithelial cilium movement (GO:0003351)7.58011458
10male meiosis (GO:0007140)7.24931842
11binding of sperm to zona pellucida (GO:0007339)7.23715223
12synaptonemal complex organization (GO:0070193)6.95535132
13multicellular organism reproduction (GO:0032504)6.94934886
14spermatid development (GO:0007286)6.91498262
15cell wall macromolecule catabolic process (GO:0016998)6.91117101
16cell wall macromolecule metabolic process (GO:0044036)6.91117101
17cilium movement (GO:0003341)6.84849463
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.80440171
19cell-cell recognition (GO:0009988)6.79602544
20plasma membrane fusion (GO:0045026)6.78640630
21synaptonemal complex assembly (GO:0007130)6.51096438
22regulation of cilium movement (GO:0003352)6.28013950
23reproduction (GO:0000003)5.75647395
24regulation of inclusion body assembly (GO:0090083)5.70861099
25DNA methylation involved in gamete generation (GO:0043046)5.64003712
26cysteine metabolic process (GO:0006534)5.41667891
27male meiosis I (GO:0007141)5.27669770
28sulfur amino acid catabolic process (GO:0000098)5.16735329
29single fertilization (GO:0007338)5.14485696
30negative regulation of inclusion body assembly (GO:0090084)4.97778155
31ventricular system development (GO:0021591)4.87081477
32spermatogenesis (GO:0007283)4.81415384
33RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.79520825
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.79520825
35male gamete generation (GO:0048232)4.79346811
36sperm capacitation (GO:0048240)4.79197304
37fertilization (GO:0009566)4.58130649
38postsynaptic membrane organization (GO:0001941)4.50431950
39negative regulation of astrocyte differentiation (GO:0048712)4.45040530
40chromosome organization involved in meiosis (GO:0070192)4.39623363
41gamete generation (GO:0007276)4.39180141
42homocysteine metabolic process (GO:0050667)4.33595838
43adenosine metabolic process (GO:0046085)4.30651253
44protein localization to cilium (GO:0061512)4.27034211
45L-serine metabolic process (GO:0006563)4.25136612
46meiotic nuclear division (GO:0007126)4.21808260
47negative regulation of oligodendrocyte differentiation (GO:0048715)4.18033820
48meiosis I (GO:0007127)4.17259029
49germ cell development (GO:0007281)4.16107311
50glial cell proliferation (GO:0014009)4.14521894
51positive regulation of oligodendrocyte differentiation (GO:0048714)4.13820028
52calcium ion-dependent exocytosis (GO:0017156)4.10210792
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.09414820
54pyrimidine nucleobase catabolic process (GO:0006208)3.99651855
55negative regulation of glycogen biosynthetic process (GO:0045719)3.99565039
56left/right pattern formation (GO:0060972)3.97707149
57regulation of response to osmotic stress (GO:0047484)3.97375121
58regulation of microtubule-based movement (GO:0060632)3.92998624
59microtubule severing (GO:0051013)3.92515818
60cell recognition (GO:0008037)3.91525419
61organic cation transport (GO:0015695)3.84883621
62serine family amino acid catabolic process (GO:0009071)3.84824805
63chaperone-mediated protein complex assembly (GO:0051131)3.77113058
64cholesterol biosynthetic process (GO:0006695)3.75787105
65seminiferous tubule development (GO:0072520)3.72071153
66microtubule nucleation (GO:0007020)3.71282927
67cellular response to cholesterol (GO:0071397)3.69844524
68epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.67841594
69cell proliferation in forebrain (GO:0021846)3.66153995
70forebrain neuron differentiation (GO:0021879)3.65143232
71regulation of development, heterochronic (GO:0040034)3.62980806
72nonmotile primary cilium assembly (GO:0035058)3.58078308
73regulation of oligodendrocyte differentiation (GO:0048713)3.57010309
74meiotic cell cycle (GO:0051321)3.53794740
75presynaptic membrane assembly (GO:0097105)3.53728511
76cochlea development (GO:0090102)3.51234639
77spermatid nucleus differentiation (GO:0007289)3.50730795
78regulation of timing of cell differentiation (GO:0048505)3.49647199
79inner ear receptor cell development (GO:0060119)3.49608976
80intraciliary transport (GO:0042073)3.48715065
81sterol biosynthetic process (GO:0016126)3.43445347
82renal system development (GO:0072001)3.42747652
83astrocyte differentiation (GO:0048708)3.41325050
84response to lipoprotein particle (GO:0055094)3.40412259
85axoneme assembly (GO:0035082)3.39247842
86negative regulation of organelle assembly (GO:1902116)3.38963957
87cerebral cortex radially oriented cell migration (GO:0021799)3.38596235
88olfactory bulb development (GO:0021772)3.37525555
89negative regulation of glycogen metabolic process (GO:0070874)3.37392316
90multicellular organismal reproductive process (GO:0048609)3.37090810
91negative regulation of smoothened signaling pathway (GO:0045879)3.33962159
92regulation of NFAT protein import into nucleus (GO:0051532)3.28193863
93behavioral defense response (GO:0002209)3.26979823
94behavioral fear response (GO:0001662)3.26979823
95regulation of plasminogen activation (GO:0010755)3.25870828
96positive regulation of cellular amide metabolic process (GO:0034250)3.25818605
97isoprenoid biosynthetic process (GO:0008299)3.24778214
98microtubule depolymerization (GO:0007019)3.23529142
99lens fiber cell development (GO:0070307)3.21437934
100sodium ion export (GO:0071436)3.20558236
101spinal cord association neuron differentiation (GO:0021527)3.18643248
102establishment of mitochondrion localization (GO:0051654)3.15267089
103radial glial cell differentiation (GO:0060019)3.14130982
104neuronal stem cell maintenance (GO:0097150)3.11510811
105alanine transport (GO:0032328)3.10504066
106sex differentiation (GO:0007548)3.07255137
107response to auditory stimulus (GO:0010996)3.07248266
108tongue development (GO:0043586)3.06249480
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.05269741
110cerebral cortex neuron differentiation (GO:0021895)3.04029179
111cranial nerve morphogenesis (GO:0021602)3.03772520
112nucleobase catabolic process (GO:0046113)3.01158110
113protein polyglutamylation (GO:0018095)2.99054393
114smoothened signaling pathway (GO:0007224)2.97242812
115chromosome condensation (GO:0030261)2.93169621
116genitalia morphogenesis (GO:0035112)2.92955394
117phosphorelay signal transduction system (GO:0000160)2.92870128
118presynaptic membrane organization (GO:0097090)2.92471265
119growth hormone secretion (GO:0030252)2.92432065
120cilium organization (GO:0044782)2.91671684
121response to pheromone (GO:0019236)2.91602766
122positive regulation of endothelial cell differentiation (GO:0045603)2.91172099
123gonadal mesoderm development (GO:0007506)2.89655366
124gene silencing by RNA (GO:0031047)2.89518008
125negative regulation of gliogenesis (GO:0014014)2.89387637
126mechanoreceptor differentiation (GO:0042490)2.89382716
127cardiac left ventricle morphogenesis (GO:0003214)2.88992954
128central nervous system myelination (GO:0022010)2.87010432
129axon ensheathment in central nervous system (GO:0032291)2.87010432
130negative regulation of glial cell differentiation (GO:0045686)2.86746426
131cellular response to sterol (GO:0036315)2.85948886
132serine family amino acid biosynthetic process (GO:0009070)2.85786049
133cell communication by electrical coupling (GO:0010644)2.85604930
134photoreceptor cell differentiation (GO:0046530)2.84108305
135eye photoreceptor cell differentiation (GO:0001754)2.84108305
136Sertoli cell development (GO:0060009)2.83693567
137dendritic spine morphogenesis (GO:0060997)2.82422392
138regulation of glial cell differentiation (GO:0045685)2.81351652
139cilium assembly (GO:0042384)2.81002642
140multicellular organismal development (GO:0007275)2.80506312
141L-serine transport (GO:0015825)2.79825837
142layer formation in cerebral cortex (GO:0021819)2.79487832
143white fat cell differentiation (GO:0050872)2.77668155
144microtubule-based movement (GO:0007018)2.76779132
145fear response (GO:0042596)2.76302081
146purine nucleotide salvage (GO:0032261)2.74402176
147neuron cell-cell adhesion (GO:0007158)2.72448864
148protein-cofactor linkage (GO:0018065)2.71598418
149regulation of energy homeostasis (GO:2000505)2.70580632
150regulation of astrocyte differentiation (GO:0048710)2.70190771
151protein-chromophore linkage (GO:0018298)2.69633600
152sulfur amino acid biosynthetic process (GO:0000097)2.67412013
153outer ear morphogenesis (GO:0042473)2.66426678
154appendage development (GO:0048736)2.65166142
155limb development (GO:0060173)2.65166142
156negative regulation of catenin import into nucleus (GO:0035414)2.65149855
157lactate metabolic process (GO:0006089)2.63509600
158cilium morphogenesis (GO:0060271)2.62401477
159primary amino compound metabolic process (GO:1901160)2.62365870
160C4-dicarboxylate transport (GO:0015740)2.61176572
161retinal ganglion cell axon guidance (GO:0031290)2.59854490
162cellular potassium ion homeostasis (GO:0030007)2.59750909
163retinal rod cell development (GO:0046548)2.58659476
164glycolytic process (GO:0006096)2.58492752
165CDP-diacylglycerol biosynthetic process (GO:0016024)2.56505101
166regulation of neurotransmitter uptake (GO:0051580)2.55971369
167nephron tubule morphogenesis (GO:0072078)2.55804905
168nephron epithelium morphogenesis (GO:0072088)2.55804905
169tRNA modification (GO:0006400)2.54939337
170central nervous system projection neuron axonogenesis (GO:0021952)2.53560800
171axonal fasciculation (GO:0007413)2.53337121
172positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.52704511
173carnitine transmembrane transport (GO:1902603)2.52366990
174G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.52039778
175amino-acid betaine transport (GO:0015838)2.48699784
176carnitine transport (GO:0015879)2.48699784
177RNA localization (GO:0006403)2.46579901
178DNA packaging (GO:0006323)2.45743701
179cilium or flagellum-dependent cell motility (GO:0001539)11.1986852

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.68217035
2EZH2_22144423_ChIP-Seq_EOC_Human7.32614294
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse6.83067077
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.76387397
5ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53260293
6GBX2_23144817_ChIP-Seq_PC3_Human2.49850595
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.39492542
8ZNF274_21170338_ChIP-Seq_K562_Hela2.25347559
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.18337950
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17850889
11GATA1_26923725_Chip-Seq_HPCs_Mouse2.15259418
12REST_21632747_ChIP-Seq_MESCs_Mouse2.13005038
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98600684
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.85848190
15ELK4_26923725_Chip-Seq_MESODERM_Mouse1.83081483
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.79280713
17SUZ12_27294783_Chip-Seq_ESCs_Mouse1.78931662
18RNF2_27304074_Chip-Seq_ESCs_Mouse1.76927637
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.75638272
20FUS_26573619_Chip-Seq_HEK293_Human1.69989772
21CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67648740
22ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67500305
23TAF15_26573619_Chip-Seq_HEK293_Human1.64603896
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64196331
25STAT6_21828071_ChIP-Seq_BEAS2B_Human1.59114803
26P300_19829295_ChIP-Seq_ESCs_Human1.52918728
27IGF1R_20145208_ChIP-Seq_DFB_Human1.52838716
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50797700
29MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49721022
30CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.47464471
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.44404778
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42730596
33UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42408412
34WDR5_24793694_ChIP-Seq_LNCAP_Human1.40760020
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40267915
36RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.37445838
37RING1B_27294783_Chip-Seq_ESCs_Mouse1.37256703
38DROSHA_22980978_ChIP-Seq_HELA_Human1.36979641
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36151470
40AR_21572438_ChIP-Seq_LNCaP_Human1.35377484
41SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34611251
42SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33474145
43SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33279797
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.32487394
45PCGF2_27294783_Chip-Seq_NPCs_Mouse1.32220099
46REST_18959480_ChIP-ChIP_MESCs_Mouse1.31481889
47CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31009573
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30518941
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30348919
50VDR_22108803_ChIP-Seq_LS180_Human1.29895671
51RUNX2_22187159_ChIP-Seq_PCA_Human1.27540225
52FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24441631
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.23437114
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.23274276
55RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22277110
56TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22135304
57EED_16625203_ChIP-ChIP_MESCs_Mouse1.21902324
58RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21506730
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19786567
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18937089
61HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18356761
62KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18010773
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.17516578
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.17130840
65MYC_27129775_Chip-Seq_CORNEA_Mouse1.16942832
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16593865
67AR_25329375_ChIP-Seq_VCAP_Human1.16366684
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.14909093
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14410678
70TP53_18474530_ChIP-ChIP_U2OS_Human1.14388711
71CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.14099231
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.13998662
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.12172807
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10121260
75KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10027267
76SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.08477687
77RAD21_21589869_ChIP-Seq_MESCs_Mouse1.08205669
78RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08202945
79GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08175164
80STAT3_23295773_ChIP-Seq_U87_Human1.07550224
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06955037
82EZH2_18974828_ChIP-Seq_MESCs_Mouse1.06363685
83RNF2_18974828_ChIP-Seq_MESCs_Mouse1.06363685
84EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06216419
85EWS_26573619_Chip-Seq_HEK293_Human1.06041625
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05591384
87CBP_20019798_ChIP-Seq_JUKART_Human1.05591384
88RNF2_27304074_Chip-Seq_NSC_Mouse1.05172642
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05011909
90TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04247338
91FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03120994
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.03036887
93SOX2_22085726_ChIP-Seq_NPCs_Mouse1.02871470
94FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01732584
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01083174
96CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01076216
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00125359
98PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99532256
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99169460
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99156494
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99156494
102JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99090472
103JUN_21703547_ChIP-Seq_K562_Human0.98946774
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.98515062
105TP53_20018659_ChIP-ChIP_R1E_Mouse0.98399966
106TET1_21490601_ChIP-Seq_MESCs_Mouse0.98196187
107ER_23166858_ChIP-Seq_MCF-7_Human0.98054985
108GATA3_21867929_ChIP-Seq_CD8_Mouse0.97962754
109CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.97942489
110SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.97740653
111SOX2_21211035_ChIP-Seq_LN229_Human0.97723388
112OCT4_19829295_ChIP-Seq_ESCs_Human0.97071669
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96543399
114CTCF_27219007_Chip-Seq_Bcells_Human0.96388639
115TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.95739207
116TP63_19390658_ChIP-ChIP_HaCaT_Human0.95723904
117CTCF_20526341_ChIP-Seq_ESCs_Human0.95316307
118BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94746777
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94351016
120SOX2_21211035_ChIP-Seq_LN229_Gbm0.94279417
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93455834
122PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.92857203
123KDM2B_26808549_Chip-Seq_REH_Human0.92733100
124SMC4_20622854_ChIP-Seq_HELA_Human0.92369525
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.91112149
126NFE2_27457419_Chip-Seq_LIVER_Mouse0.91022835
127KLF4_19829295_ChIP-Seq_ESCs_Human0.90951843
128CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89918147
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89756459
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89667568
131CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.89202162
132TCF4_22108803_ChIP-Seq_LS180_Human0.88948754
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.88799273
134* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88789986
135TP53_22573176_ChIP-Seq_HFKS_Human0.87845783
136MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87770374
137CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87372450
138CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86002608
139FLI1_21867929_ChIP-Seq_CD8_Mouse0.85907144
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85565204
141MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.85323217
142PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.84777862
143SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84757453
144BCAT_22108803_ChIP-Seq_LS180_Human0.82283770
145STAT1_17558387_ChIP-Seq_HELA_Human0.81789827
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.81733105
147RUNX1_26923725_Chip-Seq_HPCs_Mouse0.81475062
148ELF1_20517297_ChIP-Seq_JURKAT_Human0.81337470
149* P53_21459846_ChIP-Seq_SAOS-2_Human0.81080724
150BCL6_27268052_Chip-Seq_Bcells_Human0.81071666
151CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80880548
152ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80707695

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology4.69034249
2MP0003698_abnormal_male_reproductive4.22937318
3MP0001929_abnormal_gametogenesis3.58264238
4MP0008877_abnormal_DNA_methylation3.28863462
5MP0002938_white_spotting3.12635496
6MP0003329_amyloid_beta_deposits3.04061079
7MP0006292_abnormal_olfactory_placode2.98399963
8MP0005248_abnormal_Harderian_gland2.72732384
9MP0002210_abnormal_sex_determination2.52670500
10MP0005171_absent_coat_pigmentation2.47919238
11MP0008789_abnormal_olfactory_epithelium2.46763069
12MP0000566_synostosis2.41269563
13MP0005394_taste/olfaction_phenotype2.31839623
14MP0005499_abnormal_olfactory_system2.31839623
15MP0002161_abnormal_fertility/fecundity2.26214804
16MP0004859_abnormal_synaptic_plasticity2.12382738
17MP0001145_abnormal_male_reproductive2.12291661
18MP0001984_abnormal_olfaction2.01234052
19MP0005410_abnormal_fertilization10.7141747
20MP0002249_abnormal_larynx_morphology1.94020142
21MP0002254_reproductive_system_inflammat1.90815969
22MP0006276_abnormal_autonomic_nervous1.89705705
23MP0000653_abnormal_sex_gland1.87303225
24MP0000778_abnormal_nervous_system1.83220382
25MP0001486_abnormal_startle_reflex1.82421337
26MP0005646_abnormal_pituitary_gland1.72512338
27MP0004133_heterotaxia1.67456052
28MP0006072_abnormal_retinal_apoptosis1.58247261
29MP0003635_abnormal_synaptic_transmissio1.57485020
30MP0000604_amyloidosis1.56116849
31MP0003646_muscle_fatigue1.52693563
32MP0004233_abnormal_muscle_weight1.52371441
33MP0005623_abnormal_meninges_morphology1.48273840
34MP0005423_abnormal_somatic_nervous1.47491526
35MP0003183_abnormal_peptide_metabolism1.47030686
36MP0008995_early_reproductive_senescence1.44080758
37MP0004858_abnormal_nervous_system1.42066489
38MP0001293_anophthalmia1.40811043
39MP0001963_abnormal_hearing_physiology1.39883603
40MP0002234_abnormal_pharynx_morphology1.38130980
41MP0002572_abnormal_emotion/affect_behav1.37205246
42MP0003011_delayed_dark_adaptation1.34678662
43MP0009046_muscle_twitch1.33599730
44MP0010030_abnormal_orbit_morphology1.30971876
45MP0003878_abnormal_ear_physiology1.30029407
46MP0005377_hearing/vestibular/ear_phenot1.30029407
47MP0002063_abnormal_learning/memory/cond1.29306139
48MP0001502_abnormal_circadian_rhythm1.27996731
49MP0003938_abnormal_ear_development1.27707393
50MP0001529_abnormal_vocalization1.25857888
51MP0002282_abnormal_trachea_morphology1.24895525
52MP0009053_abnormal_anal_canal1.23763374
53MP0000647_abnormal_sebaceous_gland1.22234941
54MP0005670_abnormal_white_adipose1.21461976
55MP0001440_abnormal_grooming_behavior1.20291670
56MP0004270_analgesia1.18385505
57MP0000579_abnormal_nail_morphology1.18090426
58MP0002557_abnormal_social/conspecific_i1.17128181
59MP0002735_abnormal_chemical_nociception1.17077556
60MP0003115_abnormal_respiratory_system1.16773320
61MP0001346_abnormal_lacrimal_gland1.16359589
62MP0008961_abnormal_basal_metabolism1.16052262
63MP0002064_seizures1.14913214
64MP0000534_abnormal_ureter_morphology1.14819970
65MP0003634_abnormal_glial_cell1.13980079
66MP0003690_abnormal_glial_cell1.13616317
67MP0003755_abnormal_palate_morphology1.13341649
68MP0002909_abnormal_adrenal_gland1.11753085
69MP0005360_urolithiasis1.11731407
70MP0002152_abnormal_brain_morphology1.11170829
71MP0002160_abnormal_reproductive_system1.10171592
72MP0000537_abnormal_urethra_morphology1.09296594
73MP0009745_abnormal_behavioral_response1.08962467
74MP0001485_abnormal_pinna_reflex1.08154440
75MP0004885_abnormal_endolymph1.06754352
76MP0002233_abnormal_nose_morphology1.04035064
77MP0002638_abnormal_pupillary_reflex1.03568026
78MP0004147_increased_porphyrin_level1.03343558
79MP0002095_abnormal_skin_pigmentation1.02839409
80MP0003861_abnormal_nervous_system1.01189259
81MP0005645_abnormal_hypothalamus_physiol0.97453569
82MP0002697_abnormal_eye_size0.97438788
83MP0000955_abnormal_spinal_cord0.95139256
84MP0004142_abnormal_muscle_tone0.93909730
85MP0005253_abnormal_eye_physiology0.93890242
86MP0002733_abnormal_thermal_nociception0.91252618
87MP0002734_abnormal_mechanical_nocicepti0.90150724
88MP0002092_abnormal_eye_morphology0.88082770
89MP0003632_abnormal_nervous_system0.87109398
90MP0003315_abnormal_perineum_morphology0.86930573
91MP0004134_abnormal_chest_morphology0.86843984
92MP0001764_abnormal_homeostasis0.86497887
93MP0008569_lethality_at_weaning0.86036515
94MP0000751_myopathy0.85562789
95MP0000462_abnormal_digestive_system0.85541510
96MP0003942_abnormal_urinary_system0.84591092
97MP0003122_maternal_imprinting0.84538034
98MP0001286_abnormal_eye_development0.83961678
99MP0005647_abnormal_sex_gland0.83576342
100MP0002882_abnormal_neuron_morphology0.83045576
101MP0005167_abnormal_blood-brain_barrier0.82367593
102MP0009780_abnormal_chondrocyte_physiolo0.81593278
103MP0002067_abnormal_sensory_capabilities0.80734750
104MP0005551_abnormal_eye_electrophysiolog0.80614813
105MP0002089_abnormal_postnatal_growth/wei0.80488426
106MP0003631_nervous_system_phenotype0.80002704
107MP0002069_abnormal_eating/drinking_beha0.79999886
108MP0000631_abnormal_neuroendocrine_gland0.79346608
109MP0002229_neurodegeneration0.78593692
110MP0003633_abnormal_nervous_system0.78144716
111MP0000762_abnormal_tongue_morphology0.78031739
112MP0003075_altered_response_to0.77923485
113MP0005379_endocrine/exocrine_gland_phen0.77746912
114MP0001968_abnormal_touch/_nociception0.76863094
115MP0003937_abnormal_limbs/digits/tail_de0.76693206
116MP0000049_abnormal_middle_ear0.76383911
117MP0002736_abnormal_nociception_after0.75731714
118MP0001324_abnormal_eye_pigmentation0.75460581
119MP0001270_distended_abdomen0.75391814
120MP0003880_abnormal_central_pattern0.74277854
121MP0001905_abnormal_dopamine_level0.73625684
122MP0008872_abnormal_physiological_respon0.72880238
123MP0000026_abnormal_inner_ear0.72565715
124MP0003948_abnormal_gas_homeostasis0.69850799
125MP0005391_vision/eye_phenotype0.69244675
126MP0001915_intracranial_hemorrhage0.66821713
127MP0004924_abnormal_behavior0.66137532
128MP0005386_behavior/neurological_phenoty0.66137532
129MP0001661_extended_life_span0.66034143
130MP0003123_paternal_imprinting0.65802149
131MP0004811_abnormal_neuron_physiology0.64845098
132MP0004742_abnormal_vestibular_system0.62516001
133MP0002752_abnormal_somatic_nervous0.61337452
134MP0002090_abnormal_vision0.59982528
135MP0002066_abnormal_motor_capabilities/c0.59827204
136MP0003121_genomic_imprinting0.59540015
137MP0005195_abnormal_posterior_eye0.59504284
138MP0002102_abnormal_ear_morphology0.58904503
139MP0001986_abnormal_taste_sensitivity0.58277627
140MP0002184_abnormal_innervation0.57802540
141MP0000428_abnormal_craniofacial_morphol0.57607899
142MP0005187_abnormal_penis_morphology0.57601601
143MP0003136_yellow_coat_color0.54265946
144MP0002272_abnormal_nervous_system0.53846471

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.86921940
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.86921940
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.84619093
4Abnormal respiratory epithelium morphology (HP:0012253)7.02524399
5Abnormal respiratory motile cilium morphology (HP:0005938)7.02524399
6Abnormal respiratory motile cilium physiology (HP:0012261)6.93360383
7Rhinitis (HP:0012384)5.97898330
8Abnormal ciliary motility (HP:0012262)5.58587097
9Chronic bronchitis (HP:0004469)5.22736417
10Infertility (HP:0000789)4.78038278
11Megalencephaly (HP:0001355)4.48160935
12Abnormality of the labia minora (HP:0012880)4.31763264
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.18264422
14Abnormality of alanine metabolism (HP:0010916)4.18264422
15Hyperalaninemia (HP:0003348)4.18264422
16Nasal polyposis (HP:0100582)4.10526215
17Nephronophthisis (HP:0000090)4.06082977
18Neurofibrillary tangles (HP:0002185)3.66613369
19Progressive cerebellar ataxia (HP:0002073)3.65966824
20True hermaphroditism (HP:0010459)3.46616753
21Cystic liver disease (HP:0006706)3.42846560
22Hyperglycinemia (HP:0002154)3.42586087
23Pancreatic fibrosis (HP:0100732)3.40073271
24Congenital sensorineural hearing impairment (HP:0008527)3.38299157
25Abnormality of the nasal mucosa (HP:0000433)3.19724438
26Bronchiectasis (HP:0002110)3.14996275
27Chronic hepatic failure (HP:0100626)3.12352143
28White forelock (HP:0002211)3.03923573
29Morphological abnormality of the inner ear (HP:0011390)3.01312917
30Abnormality of the renal medulla (HP:0100957)2.93452808
31Pancreatic cysts (HP:0001737)2.90706745
32Occipital encephalocele (HP:0002085)2.88670226
33Abnormality of the lower motor neuron (HP:0002366)2.87165589
34Cerebral inclusion bodies (HP:0100314)2.86456030
35Patchy hypopigmentation of hair (HP:0011365)2.86354579
36Gastrointestinal atresia (HP:0002589)2.83689108
37Birth length less than 3rd percentile (HP:0003561)2.80590403
38Aplasia involving bones of the upper limbs (HP:0009823)2.78260824
39Aplasia of the phalanges of the hand (HP:0009802)2.78260824
40Aplasia involving bones of the extremities (HP:0009825)2.78260824
41Amyotrophic lateral sclerosis (HP:0007354)2.74016203
42Septo-optic dysplasia (HP:0100842)2.73433430
43Abnormality of cochlea (HP:0000375)2.72585403
44Pseudobulbar signs (HP:0002200)2.71963143
45Bronchitis (HP:0012387)2.67209776
46Esophageal atresia (HP:0002032)2.66716755
47Constricted visual fields (HP:0001133)2.66700954
48Fibular hypoplasia (HP:0003038)2.65623478
49Maternal diabetes (HP:0009800)2.64160309
50Hemivertebrae (HP:0002937)2.59867974
51Medial flaring of the eyebrow (HP:0010747)2.59544480
52Heterochromia iridis (HP:0001100)2.58746424
53Decreased electroretinogram (ERG) amplitude (HP:0000654)2.57644903
54Hemiparesis (HP:0001269)2.56888069
55Abnormality of the diencephalon (HP:0010662)2.56163242
56Optic nerve hypoplasia (HP:0000609)2.54965521
57Abnormality of permanent molar morphology (HP:0011071)2.54656120
58Abnormality of the dental root (HP:0006486)2.54656120
59Taurodontia (HP:0000679)2.54656120
60Abnormality of the dental pulp (HP:0006479)2.52691688
61Abnormality of the 4th metacarpal (HP:0010012)2.51923304
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.48257939
63Action tremor (HP:0002345)2.47070406
64Recurrent otitis media (HP:0000403)2.44928906
65Aplasia/Hypoplasia of the fibula (HP:0006492)2.41924387
66Molar tooth sign on MRI (HP:0002419)2.40263922
67Abnormality of midbrain morphology (HP:0002418)2.40263922
68Attenuation of retinal blood vessels (HP:0007843)2.40118267
69Short tibia (HP:0005736)2.37015083
70Anencephaly (HP:0002323)2.36934337
71Preaxial hand polydactyly (HP:0001177)2.36305725
72Abnormality of molar (HP:0011077)2.35969778
73Abnormality of molar morphology (HP:0011070)2.35969778
74Back pain (HP:0003418)2.35251854
75Abnormality of serum amino acid levels (HP:0003112)2.33202356
76Cutaneous finger syndactyly (HP:0010554)2.33016221
77Tubulointerstitial nephritis (HP:0001970)2.32988671
78Tubular atrophy (HP:0000092)2.27596968
79Deformed sella turcica (HP:0002681)2.27359108
80Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.22930175
81Increased corneal curvature (HP:0100692)2.22775807
82Keratoconus (HP:0000563)2.22775807
83Gonadotropin excess (HP:0000837)2.22228615
84Sclerocornea (HP:0000647)2.19529319
85Partial duplication of thumb phalanx (HP:0009944)2.19426747
86Aplasia/Hypoplasia of the tibia (HP:0005772)2.19127745
87Polydipsia (HP:0001959)2.17007288
88Abnormal drinking behavior (HP:0030082)2.17007288
89Intestinal atresia (HP:0011100)2.15032005
90Coronal craniosynostosis (HP:0004440)2.14414028
91Male infertility (HP:0003251)2.13296562
92Supernumerary spleens (HP:0009799)2.12854346
93Abnormality of serine family amino acid metabolism (HP:0010894)2.08860809
94Abnormality of glycine metabolism (HP:0010895)2.08860809
95Short nail (HP:0001799)2.08369877
96Tubulointerstitial abnormality (HP:0001969)2.07104109
97Facial hemangioma (HP:0000329)2.06161365
98Selective tooth agenesis (HP:0001592)2.03959476
99Postaxial hand polydactyly (HP:0001162)2.03593503
100J-shaped sella turcica (HP:0002680)2.02868583
101Trigonocephaly (HP:0000243)2.02296196
102Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00479123
103Short ribs (HP:0000773)2.00003356
104Postaxial foot polydactyly (HP:0001830)1.99918645
105Microglossia (HP:0000171)1.99512711
106Chorioretinal atrophy (HP:0000533)1.99234247
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98277272
108Stage 5 chronic kidney disease (HP:0003774)1.94952143
109Shawl scrotum (HP:0000049)1.94002969
110Clumsiness (HP:0002312)1.93193395
111Genital tract atresia (HP:0001827)1.93175960
112Abnormal spermatogenesis (HP:0008669)1.92787920
113Absent septum pellucidum (HP:0001331)1.92299430
114Gait imbalance (HP:0002141)1.92079420
115Oligodactyly (hands) (HP:0001180)1.87998409
116Preaxial foot polydactyly (HP:0001841)1.87567648
117Cutaneous syndactyly (HP:0012725)1.86196375
118Long clavicles (HP:0000890)1.85879337
119Myokymia (HP:0002411)1.85872688
120Median cleft lip (HP:0000161)1.85836075
121Hypoplastic pelvis (HP:0008839)1.84422144
122Synostosis involving the elbow (HP:0003938)1.83851044
123Humeroradial synostosis (HP:0003041)1.83851044
124Pendular nystagmus (HP:0012043)1.82316656
125Focal motor seizures (HP:0011153)1.80430966
126Absent frontal sinuses (HP:0002688)1.79981030
127Vaginal atresia (HP:0000148)1.79357883
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.79356437
129Duplication of thumb phalanx (HP:0009942)1.79023870
130Pigmentary retinal degeneration (HP:0001146)1.78077263
131Congenital primary aphakia (HP:0007707)1.77385461
132Renal dysplasia (HP:0000110)1.77207178
133Partial duplication of the phalanx of hand (HP:0009999)1.76802856
134Polyphagia (HP:0002591)1.75525577
135Abnormality of the aortic arch (HP:0012303)1.74700987
136Split foot (HP:0001839)1.72408879
137Rib fusion (HP:0000902)1.71725552
138Hypoplastic left heart (HP:0004383)1.71546654
139Tubulointerstitial fibrosis (HP:0005576)1.70706832
140Broad foot (HP:0001769)1.70702160
141Respiratory distress (HP:0002098)1.70449023
142Optic nerve coloboma (HP:0000588)1.70217380
143Broad alveolar ridges (HP:0000187)1.70042716
144Abnormality of dentin (HP:0010299)1.69568114
145Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.69140183
146Heterotopia (HP:0002282)1.68592445
147Congenital hepatic fibrosis (HP:0002612)1.67430956
148Broad distal phalanx of finger (HP:0009836)1.66372191
149Azoospermia (HP:0000027)1.62989195
150Short femoral neck (HP:0100864)1.61890008
151Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.58911466
152Degeneration of anterior horn cells (HP:0002398)1.58799568
153Abnormality of the anterior horn cell (HP:0006802)1.58799568
154Absent hair (HP:0002298)1.55888839
155Adactyly (HP:0009776)1.55682692
156Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.52203844
157Absent epiphyses (HP:0010577)1.52203844
158Recurrent sinusitis (HP:0011108)1.51776037
159Bell-shaped thorax (HP:0001591)1.50454477
160Nephrogenic diabetes insipidus (HP:0009806)1.49298017
161Oligodactyly (HP:0012165)1.48740543
162Large eyes (HP:0001090)1.48657931
163Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.48097009
164Short 4th metacarpal (HP:0010044)1.48097009
165Oculomotor apraxia (HP:0000657)1.47951054
166Abnormal biliary tract physiology (HP:0012439)1.46979327
167Bile duct proliferation (HP:0001408)1.46979327
168Skull defect (HP:0001362)1.46812309
169Pachygyria (HP:0001302)1.46542808
170Abnormality of the epiphyses of the hand (HP:0005924)1.45943814

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK36.32529254
2PDK46.32529254
3PASK6.10543702
4TESK14.34812399
5PRKD34.08015891
6PDK23.85631879
7LMTK23.42293495
8EPHA43.26322947
9ICK3.01158543
10EPHA32.95505140
11CAMKK12.74460928
12PHKG12.19513687
13PHKG22.19513687
14PLK42.19009580
15NTRK21.92128499
16PTK2B1.90696764
17MAP4K21.83254600
18DYRK21.76783679
19TRIB31.69253865
20WNK31.62632469
21CASK1.58335123
22BCR1.55786337
23PLK21.48359824
24CSNK1G21.35324096
25STK381.34430208
26WNK41.24517913
27WEE11.23935302
28CSNK1G31.23262612
29MARK11.20515244
30PNCK1.18920982
31ACVR1B1.18736169
32CSNK1G11.18715514
33SIK11.07894701
34KSR11.06434654
35STK391.06330066
36TYRO31.05996222
37MOS1.05474986
38CSNK1A1L1.04048017
39INSRR1.01506891
40PAK61.00354981
41CDK90.99885595
42EPHB20.99440702
43OBSCN0.93571424
44TNIK0.93505930
45SGK30.92393861
46BRSK20.91609318
47NEK20.89774371
48MUSK0.89138494
49AKT20.87336851
50SRPK10.84320059
51TESK20.81879538
52MAP3K40.81542060
53EPHB10.78769319
54MKNK10.75605178
55MAPK130.75177441
56BCKDK0.75045537
57MINK10.74593157
58PKN10.70993968
59NEK90.70882681
60SIK30.69698055
61NEK10.66630174
62CSNK1A10.66347189
63RAF10.65080935
64CAMK2D0.64457619
65PDK10.63703695
66MAP3K30.63350055
67BMPR1B0.62718675
68PLK10.60907134
69CAMK2B0.60281676
70MKNK20.56272968
71CAMK2G0.55977333
72NME10.55033455
73NTRK30.54438875
74MAP3K90.54064547
75PAK40.53609287
76CDK190.53389509
77PRKCG0.52295393
78RPS6KA40.50594595
79NEK60.48599686
80MAPK150.47578933
81PRKCE0.46889238
82MAPK120.46781253
83WNK10.46355648
84PINK10.45229291
85TSSK60.43088910
86DYRK1B0.41837917
87STK38L0.41006268
88SGK10.40710440
89CCNB10.40028261
90IRAK10.39771725
91CDC70.38210985
92DYRK1A0.38032743
93SIK20.37869470
94PRKCZ0.37175197
95BRSK10.37120246
96MARK20.36959618
97CAMK10.36925133
98DYRK30.36843915
99TRIM280.35583256
100KSR20.35271763
101CDK180.34671797
102CDK50.34517877
103CHEK10.33399939
104PRKACB0.33295568
105PRKACA0.33270054
106ERBB20.32730337
107CDK150.32372311
108VRK10.31780407
109PRKG10.31603948
110ERBB30.31457282
111PKN20.30291594
112MAP2K10.29987060
113PAK20.28806464
114PDPK10.28092624
115CDK140.27840589
116PRPF4B0.27638881
117CDK11A0.25394296
118MAPK70.25158719
119CAMK1G0.25099375
120CLK10.22835867
121TTK0.22632113
122CDK30.21451878
123PRKAA10.21127119
124FGR0.20637801
125SGK2230.20536010
126SGK4940.20536010
127UHMK10.20142522
128GRK60.19762312
129ADRBK10.19356830
130MAP3K100.19174909
131STK30.18431432
132CAMK2A0.18267250
133MAP2K70.17998078
134SCYL20.17757161
135FGFR20.17430504
136DDR20.16854415
137ROCK20.16571778
138SGK20.16417331
139ERN10.15663368
140ATR0.14584029
141PAK30.14282351
142MAP2K20.13621604
143FGFR10.12963264
144TAOK10.12156864
145TAOK20.10692955
146ROCK10.10686725
147CHEK20.09862482
148SRC0.09488747
149FYN0.09135368

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.39001632
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.32158209
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.94666143
4Dorso-ventral axis formation_Homo sapiens_hsa043202.93994161
5Propanoate metabolism_Homo sapiens_hsa006402.91802519
6Fatty acid metabolism_Homo sapiens_hsa012122.72387202
7Pyruvate metabolism_Homo sapiens_hsa006202.69708975
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.59014952
9Protein export_Homo sapiens_hsa030602.32598520
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.28675726
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.24586715
12Glucagon signaling pathway_Homo sapiens_hsa049222.10354188
13Fatty acid degradation_Homo sapiens_hsa000711.92548523
14Vitamin B6 metabolism_Homo sapiens_hsa007501.89284173
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.84819840
16Basal cell carcinoma_Homo sapiens_hsa052171.84373090
17Homologous recombination_Homo sapiens_hsa034401.80011885
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.73111294
19Hedgehog signaling pathway_Homo sapiens_hsa043401.70195140
20Arginine biosynthesis_Homo sapiens_hsa002201.59583607
21Nitrogen metabolism_Homo sapiens_hsa009101.59341824
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.53385806
23PPAR signaling pathway_Homo sapiens_hsa033201.50197808
24Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.48042870
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46103877
26Steroid biosynthesis_Homo sapiens_hsa001001.45096848
27Nicotine addiction_Homo sapiens_hsa050331.44651481
28Amphetamine addiction_Homo sapiens_hsa050311.42616163
29Glutamatergic synapse_Homo sapiens_hsa047241.32897420
30Long-term potentiation_Homo sapiens_hsa047201.32412241
31Mismatch repair_Homo sapiens_hsa034301.31118404
32Peroxisome_Homo sapiens_hsa041461.28445653
33Pentose phosphate pathway_Homo sapiens_hsa000301.28176994
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.27892733
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.26427791
36Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26066886
37Glycerolipid metabolism_Homo sapiens_hsa005611.23881892
38Cocaine addiction_Homo sapiens_hsa050301.20847271
39Circadian entrainment_Homo sapiens_hsa047131.17758346
40Salivary secretion_Homo sapiens_hsa049701.17682703
41Oxidative phosphorylation_Homo sapiens_hsa001901.17417963
42Carbon metabolism_Homo sapiens_hsa012001.16426293
43Axon guidance_Homo sapiens_hsa043601.15615001
44Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.10481315
45Biosynthesis of amino acids_Homo sapiens_hsa012301.10140216
46One carbon pool by folate_Homo sapiens_hsa006701.08847848
47Oocyte meiosis_Homo sapiens_hsa041141.06838689
48Insulin secretion_Homo sapiens_hsa049111.06122150
49Olfactory transduction_Homo sapiens_hsa047401.04806970
50Glycerophospholipid metabolism_Homo sapiens_hsa005641.04584206
51Estrogen signaling pathway_Homo sapiens_hsa049151.01708950
52Gastric acid secretion_Homo sapiens_hsa049711.01386813
53Huntingtons disease_Homo sapiens_hsa050161.01144820
54Renin secretion_Homo sapiens_hsa049241.00012684
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.98949650
56Melanogenesis_Homo sapiens_hsa049160.97283753
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95632014
58Morphine addiction_Homo sapiens_hsa050320.94282096
59Selenocompound metabolism_Homo sapiens_hsa004500.92726925
60Fructose and mannose metabolism_Homo sapiens_hsa000510.91889912
61Phototransduction_Homo sapiens_hsa047440.91557216
62Cardiac muscle contraction_Homo sapiens_hsa042600.91275162
63Calcium signaling pathway_Homo sapiens_hsa040200.90992092
64Collecting duct acid secretion_Homo sapiens_hsa049660.90764080
65Parkinsons disease_Homo sapiens_hsa050120.90537830
66Bile secretion_Homo sapiens_hsa049760.89358665
67Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.88635271
68Central carbon metabolism in cancer_Homo sapiens_hsa052300.86361524
69Cholinergic synapse_Homo sapiens_hsa047250.86313919
70Ether lipid metabolism_Homo sapiens_hsa005650.86091230
71beta-Alanine metabolism_Homo sapiens_hsa004100.86078716
72N-Glycan biosynthesis_Homo sapiens_hsa005100.85658316
73Non-homologous end-joining_Homo sapiens_hsa034500.84635726
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84171015
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.83096220
76Serotonergic synapse_Homo sapiens_hsa047260.83090469
77Taste transduction_Homo sapiens_hsa047420.81750963
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81723825
79Linoleic acid metabolism_Homo sapiens_hsa005910.81184971
80Basal transcription factors_Homo sapiens_hsa030220.81180645
81cAMP signaling pathway_Homo sapiens_hsa040240.81165683
82Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.80815001
83Glycosaminoglycan degradation_Homo sapiens_hsa005310.80726655
84Nucleotide excision repair_Homo sapiens_hsa034200.79975946
85Mineral absorption_Homo sapiens_hsa049780.79191648
86Fanconi anemia pathway_Homo sapiens_hsa034600.78876756
87Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.78215215
88Wnt signaling pathway_Homo sapiens_hsa043100.77284579
89GABAergic synapse_Homo sapiens_hsa047270.74640058
90Sulfur relay system_Homo sapiens_hsa041220.73660357
91Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72920635
92Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.72561226
93Folate biosynthesis_Homo sapiens_hsa007900.71397178
94Regulation of autophagy_Homo sapiens_hsa041400.70538739
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70347735
96Cysteine and methionine metabolism_Homo sapiens_hsa002700.69513777
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68837399
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67612373
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66117164
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65556161
101Retinol metabolism_Homo sapiens_hsa008300.65399365
102mRNA surveillance pathway_Homo sapiens_hsa030150.65378906
103VEGF signaling pathway_Homo sapiens_hsa043700.64252591
104Fatty acid elongation_Homo sapiens_hsa000620.63874590
105Arginine and proline metabolism_Homo sapiens_hsa003300.63816897
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63248737
107Spliceosome_Homo sapiens_hsa030400.61401246
108Synaptic vesicle cycle_Homo sapiens_hsa047210.57554727
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57181253
110Metabolic pathways_Homo sapiens_hsa011000.56103534
111Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55601836
112Oxytocin signaling pathway_Homo sapiens_hsa049210.55498720
113Vibrio cholerae infection_Homo sapiens_hsa051100.55046215
114Dopaminergic synapse_Homo sapiens_hsa047280.54887808
115Histidine metabolism_Homo sapiens_hsa003400.54599783
116Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53264527
117Alzheimers disease_Homo sapiens_hsa050100.53006878
118Sulfur metabolism_Homo sapiens_hsa009200.51738692
119Thyroid hormone synthesis_Homo sapiens_hsa049180.50978487
120Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50581641
121Alcoholism_Homo sapiens_hsa050340.50269633
122Base excision repair_Homo sapiens_hsa034100.47765011
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47583154
124Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46854180
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46046696
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.45301903
127Notch signaling pathway_Homo sapiens_hsa043300.44659807
128Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44607388
129Gap junction_Homo sapiens_hsa045400.43491417
130RNA degradation_Homo sapiens_hsa030180.40993892
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.40465698
132Chemical carcinogenesis_Homo sapiens_hsa052040.40263362
133Fat digestion and absorption_Homo sapiens_hsa049750.39932215
134Hippo signaling pathway_Homo sapiens_hsa043900.39834277
135Pancreatic secretion_Homo sapiens_hsa049720.36332324
136ABC transporters_Homo sapiens_hsa020100.35865311
137Tryptophan metabolism_Homo sapiens_hsa003800.35549882
138Butanoate metabolism_Homo sapiens_hsa006500.35373381
139Circadian rhythm_Homo sapiens_hsa047100.35158803
140DNA replication_Homo sapiens_hsa030300.34997886
141Prion diseases_Homo sapiens_hsa050200.34755780
142Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33082309
143Aldosterone synthesis and secretion_Homo sapiens_hsa049250.32681268
144AMPK signaling pathway_Homo sapiens_hsa041520.31500143
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30267844
146Steroid hormone biosynthesis_Homo sapiens_hsa001400.27843965

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