

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | negative regulation of astrocyte differentiation (GO:0048712) | 5.45072251 |
| 2 | axon ensheathment in central nervous system (GO:0032291) | 5.12662974 |
| 3 | central nervous system myelination (GO:0022010) | 5.12662974 |
| 4 | C4-dicarboxylate transport (GO:0015740) | 4.66491887 |
| 5 | cellular response to cholesterol (GO:0071397) | 4.48625771 |
| 6 | eye photoreceptor cell differentiation (GO:0001754) | 4.34868372 |
| 7 | chondroitin sulfate catabolic process (GO:0030207) | 4.33069446 |
| 8 | negative regulation of oligodendrocyte differentiation (GO:0048715) | 4.27645703 |
| 9 | dermatan sulfate biosynthetic process (GO:0030208) | 4.25567250 |
| 10 | response to auditory stimulus (GO:0010996) | 4.20397600 |
| 11 | L-amino acid import (GO:0043092) | 4.16447718 |
| 12 | dermatan sulfate metabolic process (GO:0030205) | 4.13802886 |
| 13 | amino acid import (GO:0043090) | 4.10350438 |
| 14 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 4.04935432 |
| 15 | negative regulation of glial cell differentiation (GO:0045686) | 4.00662261 |
| 16 | locomotory exploration behavior (GO:0035641) | 3.96529595 |
| 17 | lens fiber cell development (GO:0070307) | 3.95752504 |
| 18 | layer formation in cerebral cortex (GO:0021819) | 3.94392841 |
| 19 | neuron cell-cell adhesion (GO:0007158) | 3.94329010 |
| 20 | lateral sprouting from an epithelium (GO:0060601) | 3.92747198 |
| 21 | auditory behavior (GO:0031223) | 3.89884701 |
| 22 | alanine transport (GO:0032328) | 3.85428069 |
| 23 | regulation of astrocyte differentiation (GO:0048710) | 3.84361661 |
| 24 | cellular potassium ion homeostasis (GO:0030007) | 3.74959753 |
| 25 | L-serine transport (GO:0015825) | 3.73416104 |
| 26 | glial cell proliferation (GO:0014009) | 3.72568613 |
| 27 | protein localization to synapse (GO:0035418) | 3.69294930 |
| 28 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.68001126 |
| 29 | negative regulation of smoothened signaling pathway (GO:0045879) | 3.64611108 |
| 30 | atrial cardiac muscle cell action potential (GO:0086014) | 3.61190782 |
| 31 | exploration behavior (GO:0035640) | 3.57500984 |
| 32 | astrocyte differentiation (GO:0048708) | 3.55922807 |
| 33 | regulation of respiratory system process (GO:0044065) | 3.53370712 |
| 34 | sodium ion export (GO:0071436) | 3.51756522 |
| 35 | cellular response to sterol (GO:0036315) | 3.51586274 |
| 36 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.50583367 |
| 37 | neuroblast proliferation (GO:0007405) | 3.50280926 |
| 38 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.49041190 |
| 39 | cerebellar granule cell differentiation (GO:0021707) | 3.49015527 |
| 40 | cell communication by electrical coupling (GO:0010644) | 3.48757042 |
| 41 | regulation of neurotransmitter uptake (GO:0051580) | 3.48650969 |
| 42 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.44375497 |
| 43 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.41030212 |
| 44 | oligodendrocyte differentiation (GO:0048709) | 3.39438514 |
| 45 | cell proliferation in forebrain (GO:0021846) | 3.38171702 |
| 46 | regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307) | 3.37220539 |
| 47 | regulation of oligodendrocyte differentiation (GO:0048713) | 3.36776480 |
| 48 | glutamate receptor signaling pathway (GO:0007215) | 3.36381925 |
| 49 | negative regulation of sodium ion transport (GO:0010766) | 3.36305193 |
| 50 | postsynaptic membrane organization (GO:0001941) | 3.32961010 |
| 51 | gamma-aminobutyric acid transport (GO:0015812) | 3.31598037 |
| 52 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.31372547 |
| 53 | regulation of timing of cell differentiation (GO:0048505) | 3.30769133 |
| 54 | transmission of nerve impulse (GO:0019226) | 3.29407020 |
| 55 | myelination in peripheral nervous system (GO:0022011) | 3.25795823 |
| 56 | peripheral nervous system axon ensheathment (GO:0032292) | 3.25795823 |
| 57 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.23564207 |
| 58 | positive regulation of oligodendrocyte differentiation (GO:0048714) | 3.23299449 |
| 59 | vocalization behavior (GO:0071625) | 3.21866889 |
| 60 | cerebral cortex neuron differentiation (GO:0021895) | 3.18014084 |
| 61 | regulation of respiratory gaseous exchange (GO:0043576) | 3.17594261 |
| 62 | regulation of development, heterochronic (GO:0040034) | 3.12301399 |
| 63 | synaptic vesicle maturation (GO:0016188) | 3.12271412 |
| 64 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.10162783 |
| 65 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.09905886 |
| 66 | glial cell differentiation (GO:0010001) | 3.09440603 |
| 67 | serine transport (GO:0032329) | 3.09018371 |
| 68 | negative regulation of gliogenesis (GO:0014014) | 3.07187332 |
| 69 | neurotransmitter uptake (GO:0001504) | 3.06163036 |
| 70 | neuronal action potential propagation (GO:0019227) | 3.05615616 |
| 71 | cerebellar Purkinje cell layer development (GO:0021680) | 3.05417754 |
| 72 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.05321960 |
| 73 | neuron recognition (GO:0008038) | 3.05050942 |
| 74 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.03080537 |
| 75 | presynaptic membrane assembly (GO:0097105) | 3.01038847 |
| 76 | mechanosensory behavior (GO:0007638) | 3.00482857 |
| 77 | membrane assembly (GO:0071709) | 2.99719211 |
| 78 | axonal fasciculation (GO:0007413) | 2.98712677 |
| 79 | tongue development (GO:0043586) | 2.98658637 |
| 80 | enteric nervous system development (GO:0048484) | 2.97016984 |
| 81 | myelination (GO:0042552) | 2.96323500 |
| 82 | innervation (GO:0060384) | 2.95856618 |
| 83 | negative regulation of neurotransmitter transport (GO:0051589) | 2.95352254 |
| 84 | forebrain neuron differentiation (GO:0021879) | 2.94532764 |
| 85 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 2.93209319 |
| 86 | neuron projection regeneration (GO:0031102) | 2.93086284 |
| 87 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.92537041 |
| 88 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 2.91094055 |
| 89 | acidic amino acid transport (GO:0015800) | 2.90986407 |
| 90 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.90855343 |
| 91 | regulation of glial cell differentiation (GO:0045685) | 2.90820166 |
| 92 | neuron-neuron synaptic transmission (GO:0007270) | 2.90733207 |
| 93 | limb development (GO:0060173) | 2.90145319 |
| 94 | appendage development (GO:0048736) | 2.90145319 |
| 95 | neuronal stem cell maintenance (GO:0097150) | 2.89771247 |
| 96 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.89353156 |
| 97 | gonadal mesoderm development (GO:0007506) | 2.89219892 |
| 98 | nephron tubule formation (GO:0072079) | 2.89114555 |
| 99 | membrane repolarization (GO:0086009) | 2.88880283 |
| 100 | positive regulation of synapse assembly (GO:0051965) | 2.88633898 |
| 101 | neurotransmitter catabolic process (GO:0042135) | 2.88378971 |
| 102 | chondroitin sulfate biosynthetic process (GO:0030206) | 2.87842605 |
| 103 | dendrite morphogenesis (GO:0048813) | 2.87686234 |
| 104 | positive regulation of inositol phosphate biosynthetic process (GO:0060732) | 2.86378245 |
| 105 | negative regulation of axon extension (GO:0030517) | 2.86102174 |
| 106 | adult walking behavior (GO:0007628) | 2.84897484 |
| 107 | potassium ion import (GO:0010107) | 2.84178400 |
| 108 | dendritic spine morphogenesis (GO:0060997) | 2.83005460 |
| 109 | synaptic vesicle exocytosis (GO:0016079) | 2.82982929 |
| 110 | regulation of glutamate receptor signaling pathway (GO:1900449) | 2.82969556 |
| 111 | neuronal ion channel clustering (GO:0045161) | 2.82419718 |
| 112 | axon ensheathment (GO:0008366) | 2.82376274 |
| 113 | ensheathment of neurons (GO:0007272) | 2.82376274 |
| 114 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.81205300 |
| 115 | synapse assembly (GO:0007416) | 2.80301250 |
| 116 | regulation of synapse structural plasticity (GO:0051823) | 2.79836871 |
| 117 | neurotransmitter secretion (GO:0007269) | 2.79416475 |
| 118 | cell-cell signaling involved in cell fate commitment (GO:0045168) | 2.78512345 |
| 119 | cellular sodium ion homeostasis (GO:0006883) | 2.77790105 |
| 120 | nucleobase catabolic process (GO:0046113) | 2.77558445 |
| 121 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 2.75416205 |
| 122 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.75256096 |
| 123 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.75034855 |
| 124 | astrocyte development (GO:0014002) | 2.74802500 |
| 125 | synaptic transmission, glutamatergic (GO:0035249) | 2.74642180 |
| 126 | establishment of mitochondrion localization (GO:0051654) | 2.74022676 |
| 127 | ovulation cycle (GO:0042698) | 2.73985175 |
| 128 | developmental induction (GO:0031128) | 2.73564724 |
| 129 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.73557809 |
| 130 | limb bud formation (GO:0060174) | 2.73455170 |
| 131 | regulation of phospholipid biosynthetic process (GO:0071071) | 2.73128680 |
| 132 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.72103171 |
| 133 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 2.72015729 |
| 134 | membrane hyperpolarization (GO:0060081) | 2.71840891 |
| 135 | cochlea morphogenesis (GO:0090103) | 2.70183991 |
| 136 | negative regulation of axonogenesis (GO:0050771) | 2.69943977 |
| 137 | establishment of nucleus localization (GO:0040023) | 2.69204100 |
| 138 | glutamate secretion (GO:0014047) | 2.69064045 |
| 139 | potassium ion homeostasis (GO:0055075) | 2.67013719 |
| 140 | Sertoli cell development (GO:0060009) | 2.66719914 |
| 141 | presynaptic membrane organization (GO:0097090) | 2.66192755 |
| 142 | photoreceptor cell differentiation (GO:0046530) | 2.65723867 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.45907397 |
| 2 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.46285493 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.43241111 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.17567684 |
| 5 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 3.17515101 |
| 6 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 3.16707867 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 3.10962831 |
| 8 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 3.10962831 |
| 9 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 3.09866652 |
| 10 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 3.06404843 |
| 11 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.96996519 |
| 12 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.92453010 |
| 13 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.73819442 |
| 14 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.70551781 |
| 15 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.59244896 |
| 16 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.55218037 |
| 17 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 2.53510980 |
| 18 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.48433978 |
| 19 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.47233881 |
| 20 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.29729681 |
| 21 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.23960145 |
| 22 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 2.22018460 |
| 23 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 2.19599304 |
| 24 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.12740585 |
| 25 | REST_21632747_ChIP-Seq_MESCs_Mouse | 2.04342172 |
| 26 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.98848615 |
| 27 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.96658096 |
| 28 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.96314552 |
| 29 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.94792794 |
| 30 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.92212657 |
| 31 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.78252277 |
| 32 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 1.78231885 |
| 33 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.76704110 |
| 34 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 1.75649963 |
| 35 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.75289547 |
| 36 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.74798969 |
| 37 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.74620090 |
| 38 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.69624256 |
| 39 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.61944032 |
| 40 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.57893724 |
| 41 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.57181127 |
| 42 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.56468128 |
| 43 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.56281984 |
| 44 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.50516268 |
| 45 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.48281931 |
| 46 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.47493377 |
| 47 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.45653917 |
| 48 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.44574835 |
| 49 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.42685273 |
| 50 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.42355298 |
| 51 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.39466755 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.34892477 |
| 53 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.28662903 |
| 54 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.27775718 |
| 55 | SOX2_18358816_ChIP-ChIP_MESCs_Mouse | 1.25081105 |
| 56 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.23775977 |
| 57 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.23300095 |
| 58 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.20632156 |
| 59 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.20280500 |
| 60 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.16754866 |
| 61 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15662619 |
| 62 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.15361017 |
| 63 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.14890207 |
| 64 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.13019539 |
| 65 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.12602058 |
| 66 | STAT3_23295773_ChIP-Seq_U87_Human | 1.12427335 |
| 67 | ZIC3_20872845_ChIP-ChIP_MESCs_Mouse | 1.11176908 |
| 68 | P300_19829295_ChIP-Seq_ESCs_Human | 1.10592336 |
| 69 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.10007340 |
| 70 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.09644786 |
| 71 | * SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.09015680 |
| 72 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.05921626 |
| 73 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.05072244 |
| 74 | * KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.04930603 |
| 75 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.03604746 |
| 76 | AR_19668381_ChIP-Seq_PC3_Human | 1.03127974 |
| 77 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.02551904 |
| 78 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.02203217 |
| 79 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.01856981 |
| 80 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.01659270 |
| 81 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.00782198 |
| 82 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.00596733 |
| 83 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.00358008 |
| 84 | TCF4_23295773_ChIP-Seq_U87_Human | 1.00322601 |
| 85 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.00046424 |
| 86 | * CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.00029241 |
| 87 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 0.99811993 |
| 88 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 0.99403560 |
| 89 | * RUNX2_22187159_ChIP-Seq_PCA_Human | 0.99206969 |
| 90 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 0.99187477 |
| 91 | WT1_19549856_ChIP-ChIP_CCG9911_Human | 0.97255963 |
| 92 | * TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97061643 |
| 93 | SALL4_18804426_ChIP-ChIP_MESCs_Mouse | 0.96837581 |
| 94 | SMAD4_21799915_ChIP-Seq_A2780_Human | 0.96065292 |
| 95 | * KDM2B_26808549_Chip-Seq_K562_Human | 0.95899770 |
| 96 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.95547655 |
| 97 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 0.95405300 |
| 98 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94899161 |
| 99 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.94474945 |
| 100 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 0.92323560 |
| 101 | * KDM2B_26808549_Chip-Seq_REH_Human | 0.92252985 |
| 102 | JUN_21703547_ChIP-Seq_K562_Human | 0.91753429 |
| 103 | ISL1_27105846_Chip-Seq_CPCs_Mouse | 0.90958451 |
| 104 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.90927526 |
| 105 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 0.90842184 |
| 106 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.90101527 |
| 107 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.90101527 |
| 108 | FUS_26573619_Chip-Seq_HEK293_Human | 0.89884386 |
| 109 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 0.89106987 |
| 110 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.89031785 |
| 111 | * MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.88508444 |
| 112 | VDR_22108803_ChIP-Seq_LS180_Human | 0.86596542 |
| 113 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 0.86425865 |
| 114 | EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 0.85823079 |
| 115 | SOX9_26525672_Chip-Seq_Limbbuds_Mouse | 0.85813748 |
| 116 | WDR5_24793694_ChIP-Seq_LNCAP_Human | 0.85350620 |
| 117 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.85045139 |
| 118 | * LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.80007700 |
| 119 | * AR_25329375_ChIP-Seq_VCAP_Human | 0.79765944 |
| 120 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 0.79549898 |
| 121 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.79192422 |
| 122 | HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse | 0.78782246 |
| 123 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.77433339 |
| 124 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.77083225 |
| 125 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.77083225 |
| 126 | * NR3C1_23031785_ChIP-Seq_PC12_Mouse | 0.76798494 |
| 127 | * RXR_22108803_ChIP-Seq_LS180_Human | 0.76050546 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 3.69059176 |
| 2 | MP0004858_abnormal_nervous_system | 3.49334193 |
| 3 | MP0004885_abnormal_endolymph | 2.91129417 |
| 4 | MP0000778_abnormal_nervous_system | 2.84399444 |
| 5 | MP0000566_synostosis | 2.67676131 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 2.53096863 |
| 7 | MP0005423_abnormal_somatic_nervous | 2.45170166 |
| 8 | MP0003880_abnormal_central_pattern | 2.45016213 |
| 9 | MP0003329_amyloid_beta_deposits | 2.34273698 |
| 10 | MP0001486_abnormal_startle_reflex | 2.31877121 |
| 11 | MP0003136_yellow_coat_color | 2.24553430 |
| 12 | MP0003690_abnormal_glial_cell | 2.23813262 |
| 13 | MP0002064_seizures | 2.15740837 |
| 14 | MP0004270_analgesia | 2.15531329 |
| 15 | MP0005646_abnormal_pituitary_gland | 2.08335040 |
| 16 | MP0002063_abnormal_learning/memory/cond | 2.06626023 |
| 17 | MP0009745_abnormal_behavioral_response | 2.06421925 |
| 18 | MP0002249_abnormal_larynx_morphology | 2.05830993 |
| 19 | MP0000049_abnormal_middle_ear | 2.05807894 |
| 20 | MP0003634_abnormal_glial_cell | 1.94341609 |
| 21 | MP0010030_abnormal_orbit_morphology | 1.93690032 |
| 22 | MP0002653_abnormal_ependyma_morphology | 1.93463860 |
| 23 | MP0002572_abnormal_emotion/affect_behav | 1.84644459 |
| 24 | MP0002557_abnormal_social/conspecific_i | 1.81531370 |
| 25 | MP0002735_abnormal_chemical_nociception | 1.78346887 |
| 26 | MP0009046_muscle_twitch | 1.77893012 |
| 27 | MP0000955_abnormal_spinal_cord | 1.74217347 |
| 28 | MP0000537_abnormal_urethra_morphology | 1.72864642 |
| 29 | MP0004142_abnormal_muscle_tone | 1.69927587 |
| 30 | MP0009379_abnormal_foot_pigmentation | 1.63257378 |
| 31 | MP0001485_abnormal_pinna_reflex | 1.63052214 |
| 32 | MP0001968_abnormal_touch/_nociception | 1.59717414 |
| 33 | MP0006292_abnormal_olfactory_placode | 1.57630370 |
| 34 | MP0001984_abnormal_olfaction | 1.56312539 |
| 35 | MP0002067_abnormal_sensory_capabilities | 1.55258708 |
| 36 | MP0002733_abnormal_thermal_nociception | 1.53358604 |
| 37 | MP0002734_abnormal_mechanical_nocicepti | 1.48691610 |
| 38 | MP0002152_abnormal_brain_morphology | 1.48117142 |
| 39 | MP0008569_lethality_at_weaning | 1.46979620 |
| 40 | MP0002638_abnormal_pupillary_reflex | 1.46336982 |
| 41 | MP0002272_abnormal_nervous_system | 1.45072639 |
| 42 | MP0002882_abnormal_neuron_morphology | 1.42844888 |
| 43 | MP0001502_abnormal_circadian_rhythm | 1.42842284 |
| 44 | MP0005167_abnormal_blood-brain_barrier | 1.42480923 |
| 45 | MP0003787_abnormal_imprinting | 1.42031555 |
| 46 | MP0002736_abnormal_nociception_after | 1.41643604 |
| 47 | MP0005645_abnormal_hypothalamus_physiol | 1.38994184 |
| 48 | MP0009250_abnormal_appendicular_skeleto | 1.38767526 |
| 49 | MP0001440_abnormal_grooming_behavior | 1.36307683 |
| 50 | MP0000569_abnormal_digit_pigmentation | 1.35725603 |
| 51 | MP0003861_abnormal_nervous_system | 1.33203131 |
| 52 | MP0009780_abnormal_chondrocyte_physiolo | 1.32816871 |
| 53 | MP0000026_abnormal_inner_ear | 1.31449195 |
| 54 | MP0002184_abnormal_innervation | 1.30307768 |
| 55 | MP0003942_abnormal_urinary_system | 1.29001995 |
| 56 | MP0003632_abnormal_nervous_system | 1.28086958 |
| 57 | MP0000631_abnormal_neuroendocrine_gland | 1.27023037 |
| 58 | MP0002089_abnormal_postnatal_growth/wei | 1.26901331 |
| 59 | MP0000428_abnormal_craniofacial_morphol | 1.25924789 |
| 60 | MP0003011_delayed_dark_adaptation | 1.22046064 |
| 61 | MP0003938_abnormal_ear_development | 1.18025320 |
| 62 | MP0001299_abnormal_eye_distance/ | 1.17905256 |
| 63 | MP0009384_cardiac_valve_regurgitation | 1.16565966 |
| 64 | MP0003937_abnormal_limbs/digits/tail_de | 1.14892960 |
| 65 | MP0000579_abnormal_nail_morphology | 1.14758930 |
| 66 | MP0003137_abnormal_impulse_conducting | 1.13802614 |
| 67 | MP0003122_maternal_imprinting | 1.12666353 |
| 68 | MP0002822_catalepsy | 1.12283597 |
| 69 | MP0000534_abnormal_ureter_morphology | 1.07713556 |
| 70 | MP0004742_abnormal_vestibular_system | 1.07652758 |
| 71 | MP0000920_abnormal_myelination | 1.07611530 |
| 72 | MP0001970_abnormal_pain_threshold | 1.07157581 |
| 73 | MP0002254_reproductive_system_inflammat | 1.06075572 |
| 74 | MP0002066_abnormal_motor_capabilities/c | 1.05466714 |
| 75 | MP0005171_absent_coat_pigmentation | 1.04049573 |
| 76 | MP0004811_abnormal_neuron_physiology | 1.03773312 |
| 77 | MP0005377_hearing/vestibular/ear_phenot | 1.01237728 |
| 78 | MP0003878_abnormal_ear_physiology | 1.01237728 |
| 79 | MP0002752_abnormal_somatic_nervous | 1.01144497 |
| 80 | MP0004134_abnormal_chest_morphology | 1.00855496 |
| 81 | MP0001177_atelectasis | 1.00555255 |
| 82 | MP0002116_abnormal_craniofacial_bone | 1.00174486 |
| 83 | MP0001529_abnormal_vocalization | 1.00059906 |
| 84 | MP0003115_abnormal_respiratory_system | 0.99443873 |
| 85 | MP0004924_abnormal_behavior | 0.99370783 |
| 86 | MP0005386_behavior/neurological_phenoty | 0.99370783 |
| 87 | MP0003283_abnormal_digestive_organ | 0.99189426 |
| 88 | MP0006276_abnormal_autonomic_nervous | 0.98243782 |
| 89 | MP0002282_abnormal_trachea_morphology | 0.96971169 |
| 90 | MP0003631_nervous_system_phenotype | 0.95829463 |
| 91 | MP0001963_abnormal_hearing_physiology | 0.95257515 |
| 92 | MP0003879_abnormal_hair_cell | 0.91799859 |
| 93 | MP0005499_abnormal_olfactory_system | 0.90326452 |
| 94 | MP0005394_taste/olfaction_phenotype | 0.90326452 |
| 95 | MP0002938_white_spotting | 0.90317585 |
| 96 | MP0005551_abnormal_eye_electrophysiolog | 0.90099537 |
| 97 | MP0002229_neurodegeneration | 0.89459082 |
| 98 | MP0003183_abnormal_peptide_metabolism | 0.89111138 |
| 99 | MP0001943_abnormal_respiration | 0.88883290 |
| 100 | MP0003633_abnormal_nervous_system | 0.88601831 |
| 101 | MP0006072_abnormal_retinal_apoptosis | 0.88366121 |
| 102 | MP0003755_abnormal_palate_morphology | 0.87394349 |
| 103 | MP0003279_aneurysm | 0.85821809 |
| 104 | MP0008789_abnormal_olfactory_epithelium | 0.83956415 |
| 105 | MP0005195_abnormal_posterior_eye | 0.83283949 |
| 106 | MP0002909_abnormal_adrenal_gland | 0.80149973 |
| 107 | MP0002233_abnormal_nose_morphology | 0.80041256 |
| 108 | MP0000604_amyloidosis | 0.79024660 |
| 109 | MP0002090_abnormal_vision | 0.78988423 |
| 110 | MP0005253_abnormal_eye_physiology | 0.78866805 |
| 111 | MP0003075_altered_response_to | 0.78442959 |
| 112 | MP0004133_heterotaxia | 0.78350610 |
| 113 | MP0001501_abnormal_sleep_pattern | 0.78037346 |
| 114 | MP0005391_vision/eye_phenotype | 0.77630701 |
| 115 | MP0000647_abnormal_sebaceous_gland | 0.77471866 |
| 116 | MP0003121_genomic_imprinting | 0.77471633 |
| 117 | MP0000462_abnormal_digestive_system | 0.76824255 |
| 118 | MP0001905_abnormal_dopamine_level | 0.76015031 |
| 119 | MP0005248_abnormal_Harderian_gland | 0.75522595 |
| 120 | MP0002069_abnormal_eating/drinking_beha | 0.73754596 |
| 121 | MP0002095_abnormal_skin_pigmentation | 0.72528817 |
| 122 | MP0005379_endocrine/exocrine_gland_phen | 0.70972485 |
| 123 | MP0001986_abnormal_taste_sensitivity | 0.68653922 |
| 124 | MP0004043_abnormal_pH_regulation | 0.68400975 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Megalencephaly (HP:0001355) | 6.54853786 |
| 2 | Aplasia involving bones of the extremities (HP:0009825) | 4.31719708 |
| 3 | Aplasia involving bones of the upper limbs (HP:0009823) | 4.31719708 |
| 4 | Aplasia of the phalanges of the hand (HP:0009802) | 4.31719708 |
| 5 | Hemiparesis (HP:0001269) | 3.86087192 |
| 6 | Neurofibrillary tangles (HP:0002185) | 3.76701752 |
| 7 | Synostosis involving the elbow (HP:0003938) | 3.60449332 |
| 8 | Humeroradial synostosis (HP:0003041) | 3.60449332 |
| 9 | Split foot (HP:0001839) | 3.51438516 |
| 10 | Increased circulating renin level (HP:0000848) | 3.29771925 |
| 11 | Septo-optic dysplasia (HP:0100842) | 3.23743567 |
| 12 | Coronal craniosynostosis (HP:0004440) | 3.08353638 |
| 13 | Abnormality of binocular vision (HP:0011514) | 3.07207473 |
| 14 | Diplopia (HP:0000651) | 3.07207473 |
| 15 | Hemiplegia (HP:0002301) | 3.02028040 |
| 16 | Febrile seizures (HP:0002373) | 2.86252858 |
| 17 | Broad alveolar ridges (HP:0000187) | 2.82876656 |
| 18 | True hermaphroditism (HP:0010459) | 2.82030485 |
| 19 | Epileptic encephalopathy (HP:0200134) | 2.80598591 |
| 20 | Cerebral inclusion bodies (HP:0100314) | 2.79901469 |
| 21 | Clumsiness (HP:0002312) | 2.79682072 |
| 22 | Maternal diabetes (HP:0009800) | 2.71996234 |
| 23 | Overriding aorta (HP:0002623) | 2.67346737 |
| 24 | Gait imbalance (HP:0002141) | 2.64868801 |
| 25 | Short 4th metacarpal (HP:0010044) | 2.59830979 |
| 26 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 2.59830979 |
| 27 | Adactyly (HP:0009776) | 2.58448456 |
| 28 | Bronchomalacia (HP:0002780) | 2.58435328 |
| 29 | Generalized tonic-clonic seizures (HP:0002069) | 2.56175885 |
| 30 | Back pain (HP:0003418) | 2.54978605 |
| 31 | Absent septum pellucidum (HP:0001331) | 2.53345021 |
| 32 | Abnormality of the diencephalon (HP:0010662) | 2.51894304 |
| 33 | Polyphagia (HP:0002591) | 2.48144961 |
| 34 | Trigonocephaly (HP:0000243) | 2.46112860 |
| 35 | Abnormality of cochlea (HP:0000375) | 2.45750671 |
| 36 | Abnormality of the middle phalanges of the toes (HP:0010183) | 2.45704836 |
| 37 | Rib fusion (HP:0000902) | 2.44620942 |
| 38 | Concave nail (HP:0001598) | 2.43932681 |
| 39 | Focal motor seizures (HP:0011153) | 2.42448406 |
| 40 | Atonic seizures (HP:0010819) | 2.37721219 |
| 41 | Anomalous pulmonary venous return (HP:0010772) | 2.37407035 |
| 42 | Myokymia (HP:0002411) | 2.35131599 |
| 43 | Supranuclear gaze palsy (HP:0000605) | 2.35054714 |
| 44 | Gastrointestinal atresia (HP:0002589) | 2.34012926 |
| 45 | Neonatal short-limb short stature (HP:0008921) | 2.30465902 |
| 46 | Sleep apnea (HP:0010535) | 2.29669300 |
| 47 | Dysdiadochokinesis (HP:0002075) | 2.28927765 |
| 48 | Intestinal atresia (HP:0011100) | 2.28349048 |
| 49 | Abnormal eating behavior (HP:0100738) | 2.24489830 |
| 50 | Abnormal drinking behavior (HP:0030082) | 2.22108639 |
| 51 | Polydipsia (HP:0001959) | 2.22108639 |
| 52 | Esophageal atresia (HP:0002032) | 2.22067737 |
| 53 | Insomnia (HP:0100785) | 2.20251493 |
| 54 | Cutaneous finger syndactyly (HP:0010554) | 2.19138600 |
| 55 | Abnormality of the axillary hair (HP:0100134) | 2.19114080 |
| 56 | Abnormality of secondary sexual hair (HP:0009888) | 2.19114080 |
| 57 | Progressive cerebellar ataxia (HP:0002073) | 2.17659075 |
| 58 | Peripheral hypomyelination (HP:0007182) | 2.17151141 |
| 59 | Morphological abnormality of the middle ear (HP:0008609) | 2.16472215 |
| 60 | Pancreatic fibrosis (HP:0100732) | 2.12181563 |
| 61 | Dialeptic seizures (HP:0011146) | 2.12176138 |
| 62 | Abnormality of the 4th metacarpal (HP:0010012) | 2.10525578 |
| 63 | Hypoplastic pelvis (HP:0008839) | 2.09708931 |
| 64 | Obstructive sleep apnea (HP:0002870) | 2.09201549 |
| 65 | Metabolic alkalosis (HP:0200114) | 2.09194962 |
| 66 | Pseudobulbar signs (HP:0002200) | 2.09137598 |
| 67 | Medial flaring of the eyebrow (HP:0010747) | 2.08862418 |
| 68 | Limb dystonia (HP:0002451) | 2.08580975 |
| 69 | Intention tremor (HP:0002080) | 2.07820669 |
| 70 | Focal seizures (HP:0007359) | 2.07051142 |
| 71 | Fibular aplasia (HP:0002990) | 2.06366488 |
| 72 | Morphological abnormality of the inner ear (HP:0011390) | 2.05966266 |
| 73 | Congenital primary aphakia (HP:0007707) | 2.05693986 |
| 74 | Abnormality of the septum pellucidum (HP:0007375) | 2.04718191 |
| 75 | Fibular hypoplasia (HP:0003038) | 2.04542814 |
| 76 | Abnormal sex determination (HP:0012244) | 2.03168536 |
| 77 | Sex reversal (HP:0012245) | 2.03168536 |
| 78 | Supernumerary spleens (HP:0009799) | 2.01877341 |
| 79 | Hypoplastic left heart (HP:0004383) | 2.01516153 |
| 80 | Absence seizures (HP:0002121) | 2.01193227 |
| 81 | Aplasia/Hypoplasia of the clavicles (HP:0006710) | 2.00998281 |
| 82 | Nephronophthisis (HP:0000090) | 2.00933973 |
| 83 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.97577399 |
| 84 | Arnold-Chiari malformation (HP:0002308) | 1.96240363 |
| 85 | Specific learning disability (HP:0001328) | 1.95090390 |
| 86 | Abnormality of the pulmonary veins (HP:0011718) | 1.93923365 |
| 87 | Action tremor (HP:0002345) | 1.89793607 |
| 88 | Hypokalemic alkalosis (HP:0001949) | 1.88390169 |
| 89 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.88387189 |
| 90 | Narrow nasal bridge (HP:0000446) | 1.85603246 |
| 91 | Retinal dysplasia (HP:0007973) | 1.84983574 |
| 92 | Partial duplication of thumb phalanx (HP:0009944) | 1.83337647 |
| 93 | Sclerocornea (HP:0000647) | 1.82328429 |
| 94 | Aplasia/Hypoplasia of the hallux (HP:0008362) | 1.82142081 |
| 95 | Spastic gait (HP:0002064) | 1.81491243 |
| 96 | Genital tract atresia (HP:0001827) | 1.80130770 |
| 97 | Abnormality of midbrain morphology (HP:0002418) | 1.80022482 |
| 98 | Molar tooth sign on MRI (HP:0002419) | 1.80022482 |
| 99 | Spastic tetraparesis (HP:0001285) | 1.79963483 |
| 100 | Short hallux (HP:0010109) | 1.78433476 |
| 101 | Shallow orbits (HP:0000586) | 1.78325322 |
| 102 | Vaginal atresia (HP:0000148) | 1.77943711 |
| 103 | Renal duplication (HP:0000075) | 1.77559687 |
| 104 | Truncal ataxia (HP:0002078) | 1.76926457 |
| 105 | Pancreatic cysts (HP:0001737) | 1.76862961 |
| 106 | Drooling (HP:0002307) | 1.76673918 |
| 107 | Aplasia/Hypoplasia of the pubic bone (HP:0009104) | 1.75880604 |
| 108 | Long nose (HP:0003189) | 1.74110180 |
| 109 | Nephrogenic diabetes insipidus (HP:0009806) | 1.73885818 |
| 110 | Type II lissencephaly (HP:0007260) | 1.73715380 |
| 111 | Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658) | 1.72403576 |
| 112 | Abnormal ciliary motility (HP:0012262) | 1.72210517 |
| 113 | Hypoplastic toenails (HP:0001800) | 1.71917413 |
| 114 | Genetic anticipation (HP:0003743) | 1.71867900 |
| 115 | Elfin facies (HP:0004428) | 1.71752867 |
| 116 | Congenital malformation of the right heart (HP:0011723) | 1.71478078 |
| 117 | Double outlet right ventricle (HP:0001719) | 1.71478078 |
| 118 | Pheochromocytoma (HP:0002666) | 1.71143495 |
| 119 | Abnormality of the corticospinal tract (HP:0002492) | 1.70754374 |
| 120 | Anteriorly placed anus (HP:0001545) | 1.69863528 |
| 121 | Aplasia/Hypoplasia of the fibula (HP:0006492) | 1.69374094 |
| 122 | Status epilepticus (HP:0002133) | 1.69276469 |
| 123 | Epileptiform EEG discharges (HP:0011182) | 1.69172649 |
| 124 | Oligodactyly (hands) (HP:0001180) | 1.68408251 |
| 125 | Partial duplication of the phalanx of hand (HP:0009999) | 1.67270781 |
| 126 | Hypoplasia of the corpus callosum (HP:0002079) | 1.67257131 |
| 127 | Synostosis of carpal bones (HP:0005048) | 1.67072234 |
| 128 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.66553742 |
| 129 | Abnormality of the antihelix (HP:0009738) | 1.66553320 |
| 130 | Cystic liver disease (HP:0006706) | 1.65951885 |
| 131 | Mesangial abnormality (HP:0001966) | 1.64945572 |
| 132 | Insidious onset (HP:0003587) | 1.64768117 |
| 133 | Termporal pattern (HP:0011008) | 1.64768117 |
| 134 | Cerebellar dysplasia (HP:0007033) | 1.64598087 |
| 135 | Optic nerve hypoplasia (HP:0000609) | 1.64594467 |
| 136 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 1.64451104 |
| 137 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 1.64451104 |
| 138 | Cutaneous syndactyly (HP:0012725) | 1.64177045 |
| 139 | Anophthalmia (HP:0000528) | 1.63448825 |
| 140 | Neoplasm of the heart (HP:0100544) | 1.61733143 |
| 141 | Aplasia/Hypoplasia of the 5th finger (HP:0006262) | 1.61580943 |
| 142 | Mixed hearing impairment (HP:0000410) | 1.60970603 |
| 143 | Symphalangism affecting the phalanges of the hand (HP:0009773) | 1.60830418 |
| 144 | Severe global developmental delay (HP:0011344) | 1.60799709 |
| 145 | Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173) | 1.59860613 |
| 146 | Turricephaly (HP:0000262) | 1.59514159 |
| 147 | Hyperacusis (HP:0010780) | 1.59439574 |
| 148 | Thickened helices (HP:0000391) | 1.59006965 |
| 149 | Hyperventilation (HP:0002883) | 1.58756499 |
| 150 | Generalized hypotonia (HP:0001290) | 1.58726782 |
| 151 | Ankle clonus (HP:0011448) | 1.57965474 |
| 152 | Alacrima (HP:0000522) | 1.57249419 |
| 153 | Large for gestational age (HP:0001520) | 1.56043585 |
| 154 | Oligodactyly (HP:0012165) | 1.55875299 |
| 155 | Absent hair (HP:0002298) | 1.55760178 |
| 156 | Lissencephaly (HP:0001339) | 1.54283432 |
| 157 | Broad ribs (HP:0000885) | 1.52578317 |
| 158 | Absent toe (HP:0010760) | 1.50617722 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | NTRK2 | 4.02536938 |
| 2 | LMTK2 | 3.77313282 |
| 3 | PRKD3 | 3.26302801 |
| 4 | PHKG2 | 3.12560825 |
| 5 | PHKG1 | 3.12560825 |
| 6 | TNIK | 2.99408790 |
| 7 | EPHA4 | 2.81080750 |
| 8 | MARK1 | 2.52198343 |
| 9 | PNCK | 2.50553959 |
| 10 | TYRO3 | 2.48739086 |
| 11 | CASK | 2.39957674 |
| 12 | PAK6 | 2.31474221 |
| 13 | UHMK1 | 2.30180773 |
| 14 | TRIB3 | 2.24297950 |
| 15 | PINK1 | 2.19817829 |
| 16 | FRK | 1.95799731 |
| 17 | MINK1 | 1.93472470 |
| 18 | KSR1 | 1.92227776 |
| 19 | SIK1 | 1.78893213 |
| 20 | MAPK15 | 1.78637876 |
| 21 | MAPK13 | 1.78503478 |
| 22 | EPHB2 | 1.72838376 |
| 23 | FGFR2 | 1.63308221 |
| 24 | ICK | 1.60861956 |
| 25 | NTRK3 | 1.43238107 |
| 26 | IRAK1 | 1.42476554 |
| 27 | LIMK1 | 1.32125183 |
| 28 | ROCK2 | 1.29525781 |
| 29 | TNK2 | 1.27469598 |
| 30 | IRAK2 | 1.25449210 |
| 31 | MKNK2 | 1.24533368 |
| 32 | PAK3 | 1.23522889 |
| 33 | CDK18 | 1.21475955 |
| 34 | WNK3 | 1.21308251 |
| 35 | CDK14 | 1.21162098 |
| 36 | CDK5 | 1.20582245 |
| 37 | DYRK1A | 1.19465201 |
| 38 | ERBB4 | 1.18943122 |
| 39 | CDK15 | 1.17667129 |
| 40 | NEK6 | 1.16780567 |
| 41 | CAMK2B | 1.16123782 |
| 42 | CDK19 | 1.10510008 |
| 43 | SIK3 | 1.09574882 |
| 44 | CDK11A | 1.05253090 |
| 45 | PDGFRA | 1.00955212 |
| 46 | CAMK2G | 1.00813594 |
| 47 | MUSK | 0.99799298 |
| 48 | MAP3K9 | 0.99177086 |
| 49 | ERBB2 | 0.97483962 |
| 50 | DAPK2 | 0.97286470 |
| 51 | CSNK1G1 | 0.96748749 |
| 52 | STK38L | 0.96280549 |
| 53 | DDR2 | 0.93441923 |
| 54 | NTRK1 | 0.91403006 |
| 55 | CAMK2D | 0.90168865 |
| 56 | BCR | 0.90093480 |
| 57 | MAP3K4 | 0.89263346 |
| 58 | ROCK1 | 0.89201336 |
| 59 | MKNK1 | 0.87966413 |
| 60 | DYRK2 | 0.84787900 |
| 61 | FGR | 0.84679643 |
| 62 | FES | 0.84552911 |
| 63 | SGK1 | 0.82190194 |
| 64 | CDC42BPA | 0.76772857 |
| 65 | BMPR1B | 0.76342988 |
| 66 | DYRK1B | 0.75632163 |
| 67 | PRKCG | 0.74774776 |
| 68 | CAMKK1 | 0.71278498 |
| 69 | MAP4K2 | 0.70708171 |
| 70 | WEE1 | 0.69854172 |
| 71 | ADRBK1 | 0.69838533 |
| 72 | FGFR1 | 0.69311067 |
| 73 | BRSK1 | 0.69038478 |
| 74 | SGK223 | 0.68899036 |
| 75 | SGK494 | 0.68899036 |
| 76 | CDK3 | 0.68316632 |
| 77 | DMPK | 0.68218892 |
| 78 | MAP2K4 | 0.64751737 |
| 79 | FER | 0.63994007 |
| 80 | CAMK1 | 0.63673651 |
| 81 | MATK | 0.60693476 |
| 82 | RIPK1 | 0.59927439 |
| 83 | STK11 | 0.59589209 |
| 84 | CAMK2A | 0.58772721 |
| 85 | KSR2 | 0.58108412 |
| 86 | PRKCE | 0.56984625 |
| 87 | MAPKAPK5 | 0.55190668 |
| 88 | PLK2 | 0.53662542 |
| 89 | STK39 | 0.53114122 |
| 90 | SGK3 | 0.53073530 |
| 91 | OXSR1 | 0.53072412 |
| 92 | TESK2 | 0.52204615 |
| 93 | AKT2 | 0.50692538 |
| 94 | PRKD2 | 0.50383237 |
| 95 | PRKCZ | 0.49300452 |
| 96 | PIK3CA | 0.48549509 |
| 97 | DYRK3 | 0.48209923 |
| 98 | CSNK1G2 | 0.47817815 |
| 99 | ADRBK2 | 0.47609708 |
| 100 | MARK2 | 0.47574023 |
| 101 | CSNK1D | 0.46915116 |
| 102 | SIK2 | 0.46129671 |
| 103 | PRPF4B | 0.45556716 |
| 104 | TIE1 | 0.45157169 |
| 105 | MAPK9 | 0.44989182 |
| 106 | FYN | 0.44983593 |
| 107 | ERBB3 | 0.44945750 |
| 108 | GRK5 | 0.44897887 |
| 109 | PRKG1 | 0.44799354 |
| 110 | CAMK1G | 0.44380522 |
| 111 | CLK1 | 0.43128682 |
| 112 | CSNK1A1 | 0.42305273 |
| 113 | CSNK1G3 | 0.41867621 |
| 114 | CCNB1 | 0.40956080 |
| 115 | CAMK4 | 0.40735834 |
| 116 | SRC | 0.40645088 |
| 117 | EPHB1 | 0.39742605 |
| 118 | PRKACA | 0.39245498 |
| 119 | CSNK1A1L | 0.39057019 |
| 120 | BMX | 0.38962858 |
| 121 | MAP2K7 | 0.38757227 |
| 122 | PRKCH | 0.36972079 |
| 123 | ILK | 0.36844014 |
| 124 | RET | 0.36584000 |
| 125 | INSRR | 0.35914326 |
| 126 | RPS6KA3 | 0.35856117 |
| 127 | PKN1 | 0.35707026 |
| 128 | MOS | 0.34206324 |
| 129 | PRKDC | 0.33869788 |
| 130 | RPS6KB1 | 0.33421663 |
| 131 | PRKACG | 0.32923938 |
| 132 | MAPK12 | 0.32429912 |
| 133 | HIPK2 | 0.31520308 |
| 134 | MAPK10 | 0.30559024 |
| 135 | SGK2 | 0.30216716 |
| 136 | PDGFRB | 0.29117428 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nitrogen metabolism_Homo sapiens_hsa00910 | 4.78234164 |
| 2 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 3.45607954 |
| 3 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 2.83512642 |
| 4 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 2.65122181 |
| 5 | Nicotine addiction_Homo sapiens_hsa05033 | 2.51770761 |
| 6 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.26134886 |
| 7 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.12030579 |
| 8 | Basal cell carcinoma_Homo sapiens_hsa05217 | 2.05551993 |
| 9 | Fatty acid metabolism_Homo sapiens_hsa01212 | 2.02915602 |
| 10 | GABAergic synapse_Homo sapiens_hsa04727 | 2.00930575 |
| 11 | Axon guidance_Homo sapiens_hsa04360 | 1.92800884 |
| 12 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.87157277 |
| 13 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.70549123 |
| 14 | Circadian entrainment_Homo sapiens_hsa04713 | 1.60097299 |
| 15 | Morphine addiction_Homo sapiens_hsa05032 | 1.58055366 |
| 16 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 1.55506526 |
| 17 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 1.51946619 |
| 18 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.46258573 |
| 19 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 1.43992906 |
| 20 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.41026921 |
| 21 | Salivary secretion_Homo sapiens_hsa04970 | 1.38578058 |
| 22 | Melanogenesis_Homo sapiens_hsa04916 | 1.37869638 |
| 23 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.36908766 |
| 24 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.36709250 |
| 25 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.31586138 |
| 26 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.28722139 |
| 27 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.27140292 |
| 28 | Gap junction_Homo sapiens_hsa04540 | 1.25488666 |
| 29 | Insulin secretion_Homo sapiens_hsa04911 | 1.25037192 |
| 30 | Olfactory transduction_Homo sapiens_hsa04740 | 1.24803347 |
| 31 | Phototransduction_Homo sapiens_hsa04744 | 1.21521657 |
| 32 | Long-term depression_Homo sapiens_hsa04730 | 1.20259921 |
| 33 | Cocaine addiction_Homo sapiens_hsa05030 | 1.19193160 |
| 34 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.17870037 |
| 35 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.17774019 |
| 36 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.15104806 |
| 37 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.12276136 |
| 38 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.10720683 |
| 39 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.07785737 |
| 40 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 1.06983008 |
| 41 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.05333935 |
| 42 | Wnt signaling pathway_Homo sapiens_hsa04310 | 1.05116231 |
| 43 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.05108702 |
| 44 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.04581120 |
| 45 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.02114189 |
| 46 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.01822941 |
| 47 | Long-term potentiation_Homo sapiens_hsa04720 | 0.97833057 |
| 48 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.94642616 |
| 49 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.94276610 |
| 50 | Taste transduction_Homo sapiens_hsa04742 | 0.94094575 |
| 51 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.91943302 |
| 52 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.91366487 |
| 53 | Serotonergic synapse_Homo sapiens_hsa04726 | 0.89605604 |
| 54 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.87944315 |
| 55 | Calcium signaling pathway_Homo sapiens_hsa04020 | 0.87074860 |
| 56 | Histidine metabolism_Homo sapiens_hsa00340 | 0.85611149 |
| 57 | Amphetamine addiction_Homo sapiens_hsa05031 | 0.85512658 |
| 58 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.83188994 |
| 59 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 0.82124740 |
| 60 | Renin secretion_Homo sapiens_hsa04924 | 0.82027816 |
| 61 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.81676889 |
| 62 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.81433233 |
| 63 | Glioma_Homo sapiens_hsa05214 | 0.78548832 |
| 64 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.72998574 |
| 65 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.72116791 |
| 66 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.71707331 |
| 67 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.71114449 |
| 68 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.70784747 |
| 69 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.70449313 |
| 70 | Circadian rhythm_Homo sapiens_hsa04710 | 0.69181430 |
| 71 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.68147770 |
| 72 | Colorectal cancer_Homo sapiens_hsa05210 | 0.66790858 |
| 73 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.66763070 |
| 74 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65483321 |
| 75 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.63320313 |
| 76 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.62246771 |
| 77 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.61846929 |
| 78 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.60197597 |
| 79 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.59873213 |
| 80 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.57684422 |
| 81 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.57346841 |
| 82 | Melanoma_Homo sapiens_hsa05218 | 0.57141489 |
| 83 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.57072751 |
| 84 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.56429520 |
| 85 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.56100691 |
| 86 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.55891182 |
| 87 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.54231444 |
| 88 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.53440282 |
| 89 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.50652145 |
| 90 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.50235737 |
| 91 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49351885 |
| 92 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.49329576 |
| 93 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.49021597 |
| 94 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.48627213 |
| 95 | Tight junction_Homo sapiens_hsa04530 | 0.48013990 |
| 96 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.47120450 |
| 97 | Bile secretion_Homo sapiens_hsa04976 | 0.45690417 |
| 98 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.44899722 |
| 99 | Endometrial cancer_Homo sapiens_hsa05213 | 0.44823425 |
| 100 | Lysine degradation_Homo sapiens_hsa00310 | 0.44799461 |
| 101 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.44371836 |
| 102 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.44019881 |
| 103 | PPAR signaling pathway_Homo sapiens_hsa03320 | 0.43291053 |
| 104 | Mineral absorption_Homo sapiens_hsa04978 | 0.43106398 |
| 105 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.42529862 |
| 106 | Sulfur relay system_Homo sapiens_hsa04122 | 0.41695316 |
| 107 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.41501548 |
| 108 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.41169060 |
| 109 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.40974264 |
| 110 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.40952307 |
| 111 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.39849633 |
| 112 | Alcoholism_Homo sapiens_hsa05034 | 0.39733610 |
| 113 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.39271151 |
| 114 | ABC transporters_Homo sapiens_hsa02010 | 0.39137039 |
| 115 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.38720877 |
| 116 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.38305412 |
| 117 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.37891131 |
| 118 | Prion diseases_Homo sapiens_hsa05020 | 0.37404344 |
| 119 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.36214120 |
| 120 | Protein export_Homo sapiens_hsa03060 | 0.36206962 |

